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Acidosis
The regulation of phosphoenolpyruvate carboxykinase (GTP) synthesis in rat kidney cortex. The role of acid-base balance and glucocorticoids.
Acidosis
The transcriptional regulation of phosphoenolpyruvate carboxykinase gene in the kidney requires the HNF-1 binding site of the gene.
Acidosis, Lactic
Cytosolic Phosphoenolpyruvate Carboxykinase Deficiency: Cause of Hypoglycemia-Induced Seizure and Death.
Adenoviridae Infections
Adenovirus E1A represses the cyclic AMP-induced transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in hepatoma cells.
Autoimmune Diseases
Autoantibodies to BCOADC-E2 in patients with primary biliary cirrhosis recognize a conformational epitope.
Autoimmune Diseases
Persistence of autoantibodies against recombinant mitochondrial and nuclear pore proteins after orthotopic liver transplantation for primary biliary cirrhosis.
Blister
Apotopes and the biliary specificity of primary biliary cirrhosis.
Blister
Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis.
Blister
Pathophysiology of primary biliary cholangitis.
Carcinoma
Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) is a pro-survival, endoplasmic reticulum (ER) stress response gene involved in tumor cell adaptation to nutrient availability.
Carcinoma
Molecular cloning, and characterization and expression of dihydrolipoamide acetyltransferase component of murine pyruvate dehydrogenase complex in bile duct cancer cells.
Carcinoma, Hepatocellular
3-Aminobenzamide inhibits poly(ADP ribose) synthetase activity and induces phosphoenolpyruvate carboxykinase (GTP) in H4IIE hepatoma cells.
Carcinoma, Hepatocellular
Adenovirus E1A represses the cyclic AMP-induced transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in hepatoma cells.
Carcinoma, Hepatocellular
Effects of amino acid analogues on protein synthesis and degradation in isolated cells.
Carcinoma, Hepatocellular
Epidermal growth factor inhibits phosphoenolpyruvate carboxykinase gene expression in rat hepatocytes in primary culture.
Carcinoma, Hepatocellular
Expression of the genes for the mitochondrial and cytosolic forms of phosphoenolpyruvate carboxykinase in avian liver during development.
Carcinoma, Hepatocellular
Glucocorticoids regulate transcription of the gene for phosphoenolpyruvate carboxykinase in the liver via an extended glucocorticoid regulatory unit.
Carcinoma, Hepatocellular
Identification of a cAMP regulatory region in the gene for rat cytosolic phosphoenolpyruvate carboxykinase (GTP). Use of chimeric genes transfected into hepatoma cells.
Carcinoma, Hepatocellular
Multihormonal regulation of phosphoenolpyruvate carboxykinase gene transcription. The dominant role of insulin.
Carcinoma, Hepatocellular
Properties of phosphoenolpyruvate carboxykinase (guanosine triphosphate) synthesized in hepatoma cells in the presence of amino acid analogues.
Carcinoma, Hepatocellular
Regulated production of mature insulin by non-beta-cells.
Carcinoma, Hepatocellular
Regulation of gene expression in rat hepatocytes and hepatoma cells by insulin: quantitation of messenger ribonucleic acid's coding for tyrosine aminotransferase, tryptophan oxygenase, and phosphoenolpyruvate carboxykinase.
Carcinoma, Hepatocellular
Regulation of phosphoenolpyruvate carboxykinase gene transcription by insulin and cAMP: reciprocal actions on initiation and elongation.
Carcinoma, Hepatocellular
The effect of phorbol esters and diacylglycerol on expression of the phosphoenolpyruvate carboxykinase (GTP) gene in rat hepatoma H4IIE cells.
Carcinoma, Hepatocellular
The promoter regulatory regions of the genes for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) from the chicken and the rat have different species-specific roles in gluconeogenesis.
Carcinoma, Hepatocellular
The role of protein synthesis in the decay of phosphoenolpyruvate carboxykinase messenger RNA.
Carcinoma, Hepatocellular
Vanadate inhibits expression of the gene for phosphoenolpyruvate carboxykinase (GTP) in rat hepatoma cells.
Cholangitis
Environmental basis of primary biliary cholangitis.
Cholangitis
Novel biomarkers for primary biliary cholangitis to improve diagnosis and understand underlying regulatory mechanisms.
Cholangitis, Sclerosing
Molecular mimicry in primary biliary cirrhosis. Evidence for biliary epithelial expression of a molecule cross-reactive with pyruvate dehydrogenase complex-E2.
Cholangitis, Sclerosing
Serum reactivity against bacterial pyruvate dehydrogenase: increasing the specificity of anti-mitochondrial antibodies for the diagnosis of primary biliary cirrhosis.
Diabetes Mellitus
Phenolic Diterpenes from Rosemary Suppress cAMP Responsiveness of Gluconeogenic Gene Promoters.
Diabetes Mellitus, Type 2
A Leu184Val polymorphism in PCK1 gene is associated with type 2 diabetes in Eastern Chinese population with BMI<23 kg/m2.
Diabetes Mellitus, Type 2
Expression of phosphoenolpyruvate carboxykinase gene in human adipose tissue: induction by rosiglitazone and genetic analyses of the adipocyte-specific region of the promoter in type 2 diabetes.
Diabetes Mellitus, Type 2
Fatty acid recycling in adipocytes: a role for glyceroneogenesis and phosphoenolpyruvate carboxykinase.
Diabetes Mellitus, Type 2
Glyceroneogenesis revisited.
Diabetes Mellitus, Type 2
PCK1 and PCK2 as candidate diabetes and obesity genes.
Diabetes Mellitus, Type 2
Phosphoenolpyruvate carboxykinase (GTP): characterization of the human PCK1 gene and localization distal to MODY on chromosome 20.
Diabetes Mellitus, Type 2
Regulation of glyceroneogenesis and phosphoenolpyruvate carboxykinase by fatty acids, retinoic acids and thiazolidinediones: potential relevance to type 2 diabetes.
Diabetes Mellitus, Type 2
Two Alkaloids from Bulbs of Lycoris sanguinea MAXIM. Suppress PEPCK Expression by Inhibiting the Phosphorylation of CREB.
Diabetes Mellitus, Type 2
[Glyceroneogenesis and PEPCK-C: pharmacological targets in type 2 diabetes]
Endotoxemia
Endotoxin induced hyperlactatemia and hypoglycemia is linked to decreased mitochondrial phosphoenolpyruvate carboxykinase.
Fatty Liver
PCK1 and PCK2 as candidate diabetes and obesity genes.
Fatty Liver
Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism.
Hematologic Neoplasms
Differential epitope mapping of antibodies to PDC-E2 in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation and primary biliary cirrhosis.
Hepatitis C, Chronic
Granulomatous cholangitis in chronic hepatitis C: a new diagnostic problem in liver pathology.
Hepatitis, Autoimmune
Immunoreactivity to pyruvate dehydrogenase complex-E2 in well-defined patients with autoimmune hepatitis: Western blot analysis.
Hepatitis, Autoimmune
Serum reactivity against bacterial pyruvate dehydrogenase: increasing the specificity of anti-mitochondrial antibodies for the diagnosis of primary biliary cirrhosis.
Hyperglycemia
Overcoming diabetes-induced hyperglycemia through inhibition of hepatic phosphoenolpyruvate carboxykinase (GTP) with RNAi.
Hyperglycemia
Phosphoenolpyruvate carboxykinase (GTP) gene transcription and hyperglycemia are regulated by glucocorticoids in genetically obese db/db transgenic mice.
Hyperlactatemia
Endotoxin induced hyperlactatemia and hypoglycemia is linked to decreased mitochondrial phosphoenolpyruvate carboxykinase.
Hyperthyroidism
3,5,3'-Triiodothyronine-induced synthesis of rat liver phosphoenolpyruvate carboxykinase.
Hyperthyroidism
Renal phosphoenolpyruvate carboxykinase turnover in hypo- and hyperthyroid rat in vivo.
Hypoglycemia
Cytosolic Phosphoenolpyruvate Carboxykinase Deficiency: Cause of Hypoglycemia-Induced Seizure and Death.
Hypoglycemia
Endotoxin induced hyperlactatemia and hypoglycemia is linked to decreased mitochondrial phosphoenolpyruvate carboxykinase.
Hypoglycemia
PCK1 and PCK2 as candidate diabetes and obesity genes.
Hypoglycemia
PEPCK-C reexpression in the liver counters neonatal hypoglycemia in Pck1 (del/del) mice, unmasking role in non-gluconeogenic tissues.
Infections
Autoimmune disease triggered by infection with alphaproteobacteria.
Infections
Environmental basis of primary biliary cholangitis.
Infections
Liver autoimmunity triggered by microbial activation of natural killer T cells.
Infections
Novosphingobium aromaticivorans: a potential initiator of primary biliary cirrhosis.
Intestinal Volvulus
Phosphoenolpyruvate carboxykinase from Onchocerca volvulus and O. gibsoni.
Lipodystrophy
PCK1 and PCK2 as candidate diabetes and obesity genes.
Liver Cirrhosis, Biliary
Abnormal expression of PDC-E2 on the apical surface of biliary epithelial cells in patients with antimitochondrial antibody-negative primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Analysis of T-cell receptor beta of the T-cell clones reactive to the human PDC-E2 163-176 peptide in the context of HLA-DR53 in patients with primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Antibody to two forms of dihydrolipoamide acetyltransferase (PDC-E2) in primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Apotopes and innate immune system: Novel players in the primary biliary cirrhosis scenario.
Liver Cirrhosis, Biliary
Catalase and estradiol inhibit mitochondrial protein S-glutathionylation.
Liver Cirrhosis, Biliary
Catalytic domain of PDC-E2 contains epitopes recognized by antimitochondrial antibodies in primary biliary cirrhosis.
Liver Cirrhosis, Biliary
CD4 T-cell autoreactivity to the mitochondrial autoantigen PDC-E2 in AMA-negative primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Characterization and epitope mapping of human monoclonal antibodies to PDC-E2, the immunodominant autoantigen of primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Chromosome localization and RFLP analysis of PDC-E2: the major autoantigen of primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Comparative immunoreactivity of anti-trifluoroacetyl (TFA) antibody and anti-lipoic acid antibody in primary biliary cirrhosis: searching for a mimic.
Liver Cirrhosis, Biliary
Comprehensive mapping of HLA-A0201-restricted CD8 T-cell epitopes on PDC-E2 in primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Definition of antigen specificity for antimitochondrial proteins detected by Western blotting using native mitochondrial proteins in primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Development of an enzyme immune assay for detecting M2 autoantibodies specific for primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Differential epitope mapping of antibodies to PDC-E2 in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation and primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Environmental basis of primary biliary cholangitis.
Liver Cirrhosis, Biliary
Expression of pyruvate-dehydrogenase complex PDC-E2 on biliary epithelial cells induced by lymph nodes from primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Fine specificity of T cells reactive to human PDC-E2 163-176 peptide, the immunodominant autoantigen in primary biliary cirrhosis: implications for molecular mimicry and cross-recognition among mitochondrial autoantigens.
Liver Cirrhosis, Biliary
Granulomatous cholangitis in chronic hepatitis C: a new diagnostic problem in liver pathology.
Liver Cirrhosis, Biliary
Heterogeneity of combinatorial human autoantibodies against PDC-E2 and biliary epithelial cells in patients with primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Heterogeneous response of antimitochondrial autoantibodies and bile duct apical staining monoclonal antibodies to pyruvate dehydrogenase complex E2: the molecule versus the mimic.
Liver Cirrhosis, Biliary
HLA DRB4 0101-restricted immunodominant T cell autoepitope of pyruvate dehydrogenase complex in primary biliary cirrhosis: evidence of molecular mimicry in human autoimmune diseases.
Liver Cirrhosis, Biliary
Human combinatorial autoantibodies and mouse monoclonal antibodies to PDC-E2 produce abnormal apical staining of salivary glands in patients with coexistent primary biliary cirrhosis and Sjögren's syndrome.
Liver Cirrhosis, Biliary
Immunogenetic analysis of a panel of monoclonal IgG and IgM anti-PDC-E2/X antibodies derived from patients with primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Immunohistochemical analysis of adhesion molecules in the micro-environment of portal tracts in relation to aberrant expression of PDC-E2 and HLA-DR on the bile ducts in primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Immunoreactivity of antimitochondrial autoantibodies in Japanese patients with primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Immunoreactivity of porcine heart dihydrolipoamide acetyl- and succinyl-transferases (PDC-E2, OGDC-E2) with primary biliary cirrhosis sera: characterization of the autoantigenic region and effects of enzymatic delipoylation and relipoylation.
Liver Cirrhosis, Biliary
In situ nucleic acid detection of PDC-E2, BCOADC-E2, OGDC-E2, PDC-E1alpha, BCOADC-E1alpha, OGDC-E1, and the E3 binding protein (protein X) in primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Lipoylated and unlipoylated domains of human PDC-E2 as autoantigens in primary biliary cirrhosis: significance of lipoate attachment.
Liver Cirrhosis, Biliary
Microbial mimics are major targets of crossreactivity with human pyruvate dehydrogenase in primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Mimicry peptides of human PDC-E2 163-176 peptide, the immunodominant T-cell epitope of primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Molecular mimicry in primary biliary cirrhosis. Evidence for biliary epithelial expression of a molecule cross-reactive with pyruvate dehydrogenase complex-E2.
Liver Cirrhosis, Biliary
Novel biomarkers for primary biliary cholangitis to improve diagnosis and understand underlying regulatory mechanisms.
Liver Cirrhosis, Biliary
Ongoing activation of autoantigen-specific B cells in primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Persistence of autoantibodies against recombinant mitochondrial and nuclear pore proteins after orthotopic liver transplantation for primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Predictive role of anti-gp210 and anticentromere antibodies in long-term outcome of primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Primary biliary cirrhosis following lactobacillus vaccination for recurrent vaginitis.
Liver Cirrhosis, Biliary
Proteasome is required for class I-restricted presentation by Fcgamma receptor-mediated endocytosis in primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Sidechain biology and the immunogenicity of PDC-E2, the major autoantigen of primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Synthesis of diastereomerically pure Lys(N?-lipoyl) building blocks and their use in Fmoc/tBu solid phase synthesis of lipoyl-containing peptides for diagnosis of primary biliary cirrhosis.
Liver Cirrhosis, Biliary
[Cloning and expressing the E2 subunit of pyruvate dehydrogenase complex]
Liver Cirrhosis, Biliary
[Prediction and identification of autoepitopes of PDC-E2 specific CD8+ CTL in primary biliary cirrhosis patients]
Liver Diseases
Predictive role of anti-gp210 and anticentromere antibodies in long-term outcome of primary biliary cirrhosis.
Liver Failure
[The significance of anti-nuclear envelope (gp210) antibody in primary biliary cirrhosis]
Liver Neoplasms
Hepatic gluconeogenic key enzymes in patients with hepatic cancer.
Lung Neoplasms
Computational evaluation of natural compounds as potential inhibitors of human PEPCK-M: an alternative for lung cancer therapy.
Lung Neoplasms
Construction of human monoclonal single-chain Fv antibodies against small-cell lung cancer by phage display libraries derived from cell-immunized SCID mice engrafted with human peripheral blood lymphocytes.
Lung Neoplasms
The glycerol backbone of phospholipids derives from noncarbohydrate precursors in starved lung cancer cells.
Lymphopenia
IL-2 receptor alpha deficiency and features of primary biliary cirrhosis.
Neoplasms
Context Dependent Regulation of Human Phosphoenolpyruvate Carboxykinase Isoforms by DNA Promoter Methylation and RNA Stability.
Neoplasms
Down-regulation of the phosphoenolpyruvate carboxykinase gene in human colon tumors and induction by omega-3 fatty acids.
Neoplasms
Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease.
Neoplasms
Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) is a pro-survival, endoplasmic reticulum (ER) stress response gene involved in tumor cell adaptation to nutrient availability.
Neoplasms
PEPCK-M recoups tumor cell anabolic potential in a PKC-?-dependent manner.
Neoplasms
Pharmacology and preclinical validation of a novel anticancer compound targeting PEPCK-M.
Neoplasms
PHOSPHOPYRUVATE CARBOXYLASE IN LIVER TUMORS OF DIFFERENT GROWTH RATES.
Neoplasms
The effect of phorbol esters and diacylglycerol on expression of the phosphoenolpyruvate carboxykinase (GTP) gene in rat hepatoma H4IIE cells.
Neoplasms
The glycerol backbone of phospholipids derives from noncarbohydrate precursors in starved lung cancer cells.
Obesity
Glyceroneogenesis revisited.
Obesity
Novel splice variants of the bovine PCK1 gene.
Obesity
PCK1 and PCK2 as candidate diabetes and obesity genes.
Obesity, Maternal
Differential effects of maternal obesity and weight loss in the periconceptional period on the epigenetic regulation of hepatic insulin-signaling pathways in the offspring.
Overweight
Acute and selective regulation of glyceroneogenesis and cytosolic phosphoenolpyruvate carboxykinase in adipose tissue by thiazolidinediones in type 2 diabetes.
Rheumatic Diseases
Apotopes and the biliary specificity of primary biliary cirrhosis.
Sjogren's Syndrome
Primary biliary cirrhosis an epithelitis: evidence of abnormal salivary gland immunohistochemistry.
Starvation
3,5,3'-Triiodothyronine-induced synthesis of rat liver phosphoenolpyruvate carboxykinase.
Starvation
cAMP stimulates transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase in rat liver nuclei.
Starvation
Dietary and hormonal regulation of some enzyme activities associated with gluconeogenesis in rabbit liver.
Starvation
Induction of rat liver phosphoenolpyruvate carbonxykinase (GTP) by cyclic AMP during starvation. The permissive action of glucocorticoids.
Starvation
P-enolpyruvate carboxykinase ferroactivator. Distribution, and the influence of diabetes and starvation.
Starvation
Physiologic significance of glucocorticoids and insulin in the regulation of hepatic gluconeogenesis during starvation in rats.
Starvation
Regulation of phosphoenolpyruvate carboxykinase (GTP) in adipose tissue in vivo by glucocorticoids and insulin.
Starvation
The glycerol backbone of phospholipids derives from noncarbohydrate precursors in starved lung cancer cells.
Starvation
[Effect of starvation, cortisol and insulin on the activities of pyruvate carboxylase, phosphopyruvate carboxylase (PEP-carboxykinase) and pyruvate kinase in the liver of NZo mice in various stages of diabetes]
Tuberculosis, Pulmonary
Sera from patients with tuberculosis recognize the M2a-epitope (E2-subunit of pyruvate dehydrogenase) specific for primary biliary cirrhosis.
Urinary Tract Infections
Environmental basis of primary biliary cholangitis.
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0.004 - 0.061
oxaloacetate
0.036 - 1.256
phosphoenolpyruvate
6.8
CO2
Mg2+ concentration 2 mM, Y235A mutant. Vmax = 21 micromol/min/mg
6.8
CO2
CO2 in form of HCO3-
7.2
CO2
Mg2+ concentration 2 mM, Y235F mutant. Vmax = 5 micromol/min/mg
7.2
CO2
CO2 in form of HCO3-
7.5
CO2
Mg2+ concentration 2 mM, Y235S mutant. Vmax = 11 micromol/min/mg
7.5
CO2
CO2 in form of HCO3-
20.7
CO2
Mg2+ concentration 2 mM, wild-type. Vmax = 44 micromol/min/mg
20.7
CO2
CO2 in form of HCO3-
0.034
GDP
Mg2+ concentration 2 mM, Y235A mutant. Vmax = 15 micromol/min/mg
0.034
GDP
Mg2+ concentration 7.5 mM, Y235A mutant. Vmax = 15 micromol/min/mg
0.035
GDP
Mg2+ concentration 5 mM, Y235A mutant. Vmax = 15 micromol/min/mg
0.04
GDP
Mg2+ concentration 5 mM, Y235S mutant. Vmax = 10 micromol/min/mg
0.041
GDP
Mg2+ concentration 7.5 mM, wild-type. Vmax = 35 micromol/min/mg
0.044
GDP
Mg2+ concentration 2 mM, Y235S mutant. Vmax = 11 micromol/min/mg
0.044
GDP
Mg2+ concentration 5 mM, wild-type. Vmax = 35 micromol/min/mg
0.045
GDP
Mg2+ concentration 2 mM, wild-type. Vmax = 33 micromol/min/mg
0.047
GDP
Mg2+ concentration 2 mM, Y235F mutant. Vmax = 3 micromol/min/mg
0.053
GDP
Mg2+ concentration 7.5 mM, Y235S mutant. Vmax = 11 micromol/min/mg
0.06
GDP
Mg2+ concentration 5 mM, Y235F mutant. Vmax = 3 micromol/min/mg
0.067
GDP
Mg2+ concentration 7.5 mM, Y235F mutant. Vmax = 3 micromol/min/mg
20.6
GDP
-
in 100 mM HEPES-NaOH, pH 8, 3.6 mM L-malate, 10 mM dithiothreitol, 2 mM MgCl2, 0.2 mM MnCl2, at 37°C
0.023
GTP
-
in 100 mM HEPES-NaOH, pH 7.2, 100 mM KHCO3, 10 mM dithiothreitol, 2 mM MgCl2, 0.2 mM MnCl2, at 37°C
0.026
GTP
Y235F mutant, Vmax = 41 micromol/min/mg
0.043
GTP
Y235S mutant, Vmax = 3 micromol/min/mg
0.059
GTP
Y235A mutant, Vmax = 3 micromol/min/mg
0.064
GTP
wild-type, Vmax = 39 micromol/min/mg
0.004
oxaloacetate
-
in 100 mM HEPES-NaOH, pH 7.2, 100 mM KHCO3, 10 mM dithiothreitol, 2 mM MgCl2, 0.2 mM MnCl2, at 37°C
0.033
oxaloacetate
wild-type, Vmax = 35 micromol/min/mg
0.038
oxaloacetate
Y235F mutant, Vmax = 39 micromol/min/mg
0.047
oxaloacetate
Y235A mutant, Vmax = 3 micromol/min/mg
0.061
oxaloacetate
Y235S mutant, Vmax = 3 micromol/min/mg
0.036
phosphoenolpyruvate
Mn2+ concentration 1.5 mM, Mg2+ concentration 2 mM, Y235F mutant. Vmax = 3 micromol/min/mg
0.217
phosphoenolpyruvate
Mn2+ concentration 1.5 mM, Mg2+ concentration 2 mM, wild-type. Vmax = 31 micromol/min/mg
0.45
phosphoenolpyruvate
-
in 100 mM HEPES-NaOH, pH 8, 3.6 mM L-malate, 10 mM dithiothreitol, 2 mM MgCl2, 0.2 mM MnCl2, at 37°C
0.919
phosphoenolpyruvate
Mn2+ concentration 1.5 mM, Mg2+ concentration 2 mM, Y235A mutant. Vmax = 20 micromol/min/mg
1.256
phosphoenolpyruvate
Mn2+ concentration 1.5 mM, Mg2+ concentration 2 mM, Y235S mutant. Vmax = 15 micromol/min/mg
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Ting, C.N.; Burgess, D.L.; Chamberlain, J.S.; Keith, T.P.; Falls, K.; Meisler, M.H.
Phosphoenolpyruvate carboxykinase (GTP): characterization of the human PCK1 gene and localization distal to MODY on chromosome 20
Genomics
16
698-706
1993
Homo sapiens
brenda
Foley, L.H.; Wang, P.; Dunten, P.; Ramsey, G.; Gubler, M.L.; Wertheimer, S.J.
Modified 3-alkyl-1,8-dibenzylxanthines as GTP-competitive inhibitors of phosphoenolpyruvate carboxykinase
Bioorg. Med. Chem. Lett.
13
3607-3610
2003
Homo sapiens
brenda
Dunten, P.; Belunis, C.; Crowther, R.; Hollfelder, K.; Kammlott, U.; Levin, W.; Michel, H.; Ramsey, G.B.; Swain, A.; Weber, D.; Wertheimer, S.J.
Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site
J. Mol. Biol.
316
257-264
2002
Homo sapiens
brenda
Cadoudal, T.; Leroyer, S.; Reis, A.F.; Tordjman, J.; Durant, S.; Fouque, F.; Collinet, M.; Quette, J.; Chauvet, G.; Beale, E.; Velho, G.; Antoine, B.; Benelli, C.; Forest, C.
Proposed involvement of adipocyte glyceroneogenesis and phosphoenolpyruvate carboxykinase in the metabolic syndrome
Biochimie
87
27-32
2005
Homo sapiens
brenda
Case, C.L.; Mukhopadhyay, B.
Kinetic characterization of recombinant human cytosolic phosphoenolpyruvate carboxykinase with and without a His10-tag
Biochim. Biophys. Acta
1770
1576-1584
2007
Homo sapiens
brenda
Beale, E.G.; Harvey, B.J.; Forest, C.
PCK1 and PCK2 as candidate diabetes and obesity genes
Cell Biochem. Biophys.
48
89-95
2007
Homo sapiens, Mus musculus
brenda
Dharmarajan, L.; Case, C.L.; Dunten, P.; Mukhopadhyay, B.
Tyr235 of human cytosolic phosphoenolpyruvate carboxykinase influences catalysis through an anion-quadrupole interaction with phosphoenolpyruvate carboxylate
FEBS J.
275
5810-5819
2008
Homo sapiens (P35558)
brenda
Cadoudal, T.; Glorian, M.; Massias, A.; Fouque, F.; Forest, C.; Benelli, C.
Retinoids upregulate phosphoenolpyruvate carboxykinase and glyceroneogenesis in human and rodent adipocytes
J. Nutr.
138
1004-1009
2008
Rattus norvegicus, Homo sapiens (P35558), Homo sapiens
brenda
Chang, T.J.; Lee, W.J.; Chang, H.M.; Lee, K.C.; Chuang, L.M.
Expression of subcutaneous adipose tissue phosphoenolpyruvate carboxykinase correlates with body mass index in nondiabetic women
Metab. Clin. Exp.
57
367-372
2008
Homo sapiens
brenda
Yang, J.; Kong, X.; Martins-Santos, M.E.; Aleman, G.; Chaco, E.; Liu, G.E.; Wu, S.Y.; Samols, D.; Hakimi, P.; Chiang, C.M.; Hanson, R.W.
Activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic nuclear factor 4alpha
J. Biol. Chem.
284
27042-27053
2009
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Valle, A.; Cabrera, G.; Cantero, D.; Bolivar, J.
Heterologous expression of the human phosphoenol pyruvate carboxykinase (hPEPCK-M) improves hydrogen and ethanol synthesis in the Escherichia coli dcuD mutant when grown in a glycerol-based medium
New Biotechnol.
35
1-12
2017
Homo sapiens (Q16822), Homo sapiens
brenda