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Information on EC 4.1.1.29 - sulfinoalanine decarboxylase and Organism(s) Homo sapiens

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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.29 sulfinoalanine decarboxylase
IUBMB Comments
A pyridoxal-phosphate protein. Also acts on L-cysteate. The 1992 edition of the Enzyme List erroneously gave the name sulfoalanine decarboxylase to this enzyme.
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This record set is specific for:
Homo sapiens
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
cysteine sulfinic acid decarboxylase, cysteine sulfinate decarboxylase, cysteinesulfinate decarboxylase, cysteinesulfinic acid decarboxylase, cysteine-sulfinate decarboxylase, cgcsad1, undec1a, cgcsad2, l-cysteine sulfinate decarboxylase, csadcase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CAD
-
-
-
-
CADCase
-
-
-
-
CSAD
-
-
-
-
CSAD/CAD
-
-
-
-
CSADCase
-
-
-
-
CSD
-
-
-
-
Cysteic acid decarboxylase
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-
-
-
Cysteic decarboxylase
-
-
-
-
Cysteine sulfinate decarboxylase
-
-
-
-
Cysteine sulfinic acid decarboxylase
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-
-
-
Cysteine-sulfinate decarboxylase
-
-
-
-
Cysteinesulfinate decarboxylase
-
-
-
-
Cysteinesulfinic acid decarboxylase
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-
-
-
Decarboxylase, cysteinesulfinate
-
-
-
-
L-Cysteine sulfinate carboxy-lyase
-
-
-
-
L-Cysteinesulfinic acid decarboxylase
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-
-
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Sulfinoalanine decarboxylase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
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-
-
-
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
3-sulfino-L-alanine carboxy-lyase (hypotaurine-forming)
A pyridoxal-phosphate protein. Also acts on L-cysteate. The 1992 edition of the Enzyme List erroneously gave the name sulfoalanine decarboxylase to this enzyme.
CAS REGISTRY NUMBER
COMMENTARY hide
62213-10-9
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-Cysteine sulfinate
2-Aminoethane sulfinate + CO2
show the reaction diagram
-
-
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cysteine
-
cysteine is able to enter the active site of the enzyme, interact with the pyridoxal 5'-phosphate-lysine internal aldimine, form a cysteine-pyridoxal 5'-phosphate aldimine and undergo intramolecular nucleophilic cyclization through its sulfhydryl group, leading to irreversible inactivation. Reaction is similar for aspartate decarboxylase, glutamate decarboxylase and cysteine sulfinic acid decarboxylase
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3.61
-
presence of 5 mM cysteine, pH 7.0, temperature not specified in the publication
4.89
-
pH 7.0, temperature not specified in the publication
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
GADL1_HUMAN
521
0
59246
Swiss-Prot
other Location (Reliability: 1)
CSAD_HUMAN
493
0
55023
Swiss-Prot
other Location (Reliability: 2)
PDB
SCOP
CATH
UNIPROT
ORGANISM
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
3.6% of patients suffering from autoimmune polyendocrine syndrome type 1 are positive for antibodies against the enzyme. Antibodies cross-react with glutamic acid decarboxylase, aromatic L-amino acid decarboxylase and histidine decarboxylase
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Skoldberg, F.; Rorsman, F.; Perheentupa, J.; Landin-Olsson, M.; Husebye, E.S.; Gustafsson, J.; Kampe, O.
Analysis of antibody reactivity against cysteine sulfinic acid decarboxylase, a pyridoxal phosphate-dependent enzyme, in endocrine autoimmune disease
J. Clin. Endocrinol. Metab.
89
1636-1640
2004
Homo sapiens (Q9Y600), Homo sapiens
Manually annotated by BRENDA team
Liu, P.; Torrens-Spence, M.P.; Ding, H.; Christensen, B.M.; Li, J.
Mechanism of cysteine-dependent inactivation of aspartate/glutamate/cysteine sulfinic acid alpha-decarboxylases
Amino Acids
44
391-404
2013
Homo sapiens
Manually annotated by BRENDA team