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Information on EC 4.1.1.21 - phosphoribosylaminoimidazole carboxylase and Organism(s) Gallus gallus

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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.21 phosphoribosylaminoimidazole carboxylase
IUBMB Comments
While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely EC 6.3.4.18, 5-(carboxyamino)imidazole ribonucleotide synthase and EC 5.4.99.18, 5-(carboxyamino)imidazole ribonucleotide mutase . 5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate.
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Gallus gallus
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Word Map
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  • 4.1.1.21
  • saicars
  • n5-cair
  • phosphoribosylaminoimidazolesuccinocarboxamide
  • 4-carboxy-5-aminoimidazole
  • 6.3.2.6
  • aircs
  • n5-carboxyaminoimidazole
  • samdc
  • analysis
The taxonomic range for the selected organisms is: Gallus gallus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
paics, phosphoribosylaminoimidazole carboxylase, air carboxylase, class ii pure, aminoimidazole ribonucleotide carboxylase, phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5-Amino-1-ribosylimidazole 5-phosphate carboxylase
-
-
-
-
5-Phosphoribosyl-5-aminoimidazole carboxylase
-
-
-
-
AIR carboxylase
AIRC
-
-
-
-
aminoimidazole ribonucleotide carboxylase
-
-
Carboxylyase, phosphoribosylaminoimidazole
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
carboxylation
-
-
-
-
decarboxylation
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]
While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely EC 6.3.4.18, 5-(carboxyamino)imidazole ribonucleotide synthase and EC 5.4.99.18, 5-(carboxyamino)imidazole ribonucleotide mutase [3]. 5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate.
CAS REGISTRY NUMBER
COMMENTARY hide
9032-04-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-(5-Phosphoribosyl)-5-aminoimidazole + CO2
1-(5-Phosphoribosyl)-5-amino-4-imidazolecarboxylate
show the reaction diagram
1-(5-Phosphoribosyl)-5-aminoimidazole + CO2
?
show the reaction diagram
-
enzyme in the biosynthetic pathway to AMP
-
-
?
additional information
?
-
-
AIR carboxylase cannot use N5-carboxyaminoimidazole ribonucleotide, 5-amino-1-(beta-D-ribofuranosyl)pyrazole-4-carboxylate 5'-phosphate, and 5-amino-1-(beta-D-ribofuranosyl)-1,2,3-triazole-4-carboxylate 5'-phosphate as substrates
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
1-(5-Phosphoribosyl)-5-aminoimidazole + CO2
?
show the reaction diagram
-
enzyme in the biosynthetic pathway to AMP
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-nitro-1-(beta-D-ribofuranosyl)pyrrole 5'-phosphate
-
-
4-nitro-1-(-beta-D-ribofuranosyl)pyrazole 5'-phosphate
-
-
4-nitro-1-(beta-D-ribofuranosyl)imidazole 5'-phosphate
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-
4-Nitro-5-aminoimidazole ribonucleotide
5-Amino-1(5'-phospho-beta-D-ribofuranosyl)-4-nitroimidazole
-
-
5-amino-1-(beta-D-ribofuranosyl)-1,2,3-triazole-4-carboxylate 5'-phosphate
-
-
5-amino-1-(beta-D-ribofuranosyl)-4-nitropyrazole 5'-phosphate
-
-
5-amino-1-(beta-D-ribofuranosyl)imidazole-4-carboxaldehyde 5'-phosphate
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-
5-amino-1-(beta-D-ribofuranosyl)pyrazole-4-carboxylate 5'-phosphate
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-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.076
1-(5-phosphoribosyl)-5-aminoimidazole
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-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
40
1-(5-phosphoribosyl)-5-aminoimidazole
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-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.022
4-nitro-1-(-beta-D-ribofuranosyl)pyrazole 5'-phosphate
-
in 50 mM Tris-HCl, 0.5 mM EDTA, pH 8.0
0.0013
4-nitro-1-(beta-D-ribofuranosyl)imidazole 5'-phosphate
-
in 50 mM Tris-HCl, 0.5 mM EDTA, pH 8.0
0.00000034
4-Nitro-5-aminoimidazole ribonucleotide
-
in 50 mM Tris-HCl, 0.5 mM EDTA, pH 8.0
0.0028
5-amino-1-(beta-D-ribofuranosyl)-1,2,3-triazole-4-carboxylate 5'-phosphate
-
in 50 mM Tris-HCl, 0.5 mM EDTA, pH 8.0
0.00039
5-amino-1-(beta-D-ribofuranosyl)-4-nitropyrazole 5'-phosphate
-
in 50 mM Tris-HCl, 0.5 mM EDTA, pH 8.0
0.062
5-amino-1-(beta-D-ribofuranosyl)imidazole-4-carboxaldehyde 5'-phosphate
-
in 50 mM Tris-HCl, 0.5 mM EDTA, pH 8.0
0.006
5-amino-1-(beta-D-ribofuranosyl)pyrazole-4-carboxylate 5'-phosphate
-
in 50 mM Tris-HCl, 0.5 mM EDTA, pH 8.0
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.1
3-nitro-1-(beta-D-ribofuranosyl)pyrrole 5'-phosphate
Gallus gallus
-
IC50 above 0.1 mM
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PUR6_CHICK
426
0
47240
Swiss-Prot
other Location (Reliability: 2)
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
prolonged dialysis of more than 12 h, results in 50% loss of activity
-
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C, stable for at least 6 months
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hilton Patey, C.A.; Shaw, G.
Purification and properties of an enzyme duet, phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthetase, involved in the biosynthesis of purine nucleotides de novo
Biochem. J.
135
543-545
1973
Gallus gallus
Manually annotated by BRENDA team
Firestine, S.M.; Davisson, V.J.
Carboxylase in de novo purine biosynthesis. Characterization of the Gallus gallus bifunctional enzyme
Biochemistry
33
11917-11926
1994
Gallus gallus
Manually annotated by BRENDA team
Firestine, S.M.; Poon, S.W.; Mueller, E.J.; Stubbe, J.; Davisson, V.J.
Reactions catalyzed by 5-aminoimidazole ribonucleotide carboxylases from Escherichia coli and Gallus gallus: a case for divergent catalytic mechanisms ?
Biochemistry
33
11927-11934
1994
Escherichia coli, Gallus gallus
Manually annotated by BRENDA team
Firestine, S.M.; Davisson, V.J.
A tight binding-inhibitor of 5-aminoimidazole ribonucleotide carboxylase
J. Med. Chem.
36
3484-3486
1993
Gallus gallus
Manually annotated by BRENDA team
Firestine, S.; Wu, W.; Youn, H.; Jo Davisson, V.
Interrogating the mechanism of a tight binding inhibitor of AIR carboxylase
Bioorg. Med. Chem.
17
794-803
2009
Gallus gallus
Manually annotated by BRENDA team