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Information on EC 4.1.1.17 - ornithine decarboxylase and Organism(s) Homo sapiens

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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.17 ornithine decarboxylase
IUBMB Comments
A pyridoxal-phosphate protein.
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This record set is specific for:
Homo sapiens
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
Synonyms
odc, ornithine decarboxylase, ldodc, lysine/ornithine decarboxylase, s-adenosylmethionine decarboxylase/ornithine decarboxylase, ldc/odc, odc-paralogue, xodc2, adometdc/odc, ddodc, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
bODC
-
-
-
-
Decarboxylase, ornithine
-
-
-
-
ODC-paralogue
-
-
-
-
ornithine decarboxylase
-
-
XODC1
-
-
-
-
XODC2
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
SYSTEMATIC NAME
IUBMB Comments
L-ornithine carboxy-lyase (putrescine-forming)
A pyridoxal-phosphate protein.
CAS REGISTRY NUMBER
COMMENTARY hide
9024-60-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-ornithine
putrescine + CO2
show the reaction diagram
-
very weak activity
-
?
L-Orn
?
show the reaction diagram
-
alteration in the key enzyme in the growth-associated pathway of polyamine biosynthesis may play a role in colon tumor progression
-
-
?
L-Orn
Putrescine + CO2
show the reaction diagram
-
-
-
-
?
L-ornithine
putrescine + CO2
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-Orn
?
show the reaction diagram
-
alteration in the key enzyme in the growth-associated pathway of polyamine biosynthesis may play a role in colon tumor progression
-
-
?
L-ornithine
putrescine + CO2
show the reaction diagram
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(-)-epigallocatechin-3-gallate
-
polyphenolic compound of green tea with putative anti-cancer activity
(DL)-difluoromethylornithine
-
irreversible inactivation, 50% inhibition at 0.0075 mM D-difluoromethylornithine
1-amino-oxy-3-aminopropane
i.e. APA, analysis of the mode of the inhibitor binding to the enzyme, no oxime formation between APA and pyridoxal 5'-phosphate, homology modelling, overview
alpha-difluoromethylornithine
alpha-DL-difluoromethylornithine
a medically used, irreversible inhibitor of ODC
antizyme
-
antizyme 1
-
ODC is regulated by specific inhibitors, antizymes which in turn are inhibited by antizyme inhibitors. ODC alone is not degraded in reticulocyte lysate, whereas in the presence of antizyme 1, the degradation occurs rapidly. When antizyme inhibitor or ODC paralogue is added to the mixture, the antizyme 1-induced degradation of ODC is prevented.
-
Antizyme1
AZ1, molecular basis for the inactivation of ODC by AZ1, analysis of the interactions between ODC and AZ1, overview. The ODC-cAZ1 complex forms a heterodimer, which consists of one ODC monomer and one AZ1 molecule, AZ1 is embedded into a concave surface formed between the N- and C-domains of ODC. Binding of the truncated cAZ1 to ODC occludes the binding of a second molecule of ODC to form the active homodimer, thus the substrate binding site is disrupted and ODC is inactivated. The binding of cAZ1 to ODC causes a global conformational change of ODC and renders its C-terminal region flexible, therefore exposing this region for degradation by the 26S proteasome. AZ1 inhibits ODC activity, exhibits anti-tumor activities, and may be considered a tumor suppressor
-
D-ornithine
-
1.5 mM, 50% inhibition
DL-alpha-difluoromethylornithine
DFMO, an irreversible suicide inhibitor. DFMO inhibits growth of endometrial cancer cells in vitro and DFMO treatment significantly reduces endometrial tumor growth in vivo
L-arginine
-
L-arginine reduces cell proliferation and ornithine decarboxylase activity in patients with colorectal adenoma and adenocarcinoma, overview
methyl N-[[3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl]methyl]-1-methylhistidinate
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methyl N-[[3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl]methyl]histidinate
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methyl N5-(tert-butoxycarbonyl)-N2-{[3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl]methyl}-L-ornithinate
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N-acetylcysteine
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decreases enzyme activity in lung carcinoma NCI-H82 cells and reduces the cell viability, overview
Ornithine decarboxylase antizyme
-
ornithine decarboxylase antizymes are proteins which negatively regulate cellular polyamine levels via their affects on polyamine synthesis and cellular uptake, development of a computer tool, OAF or ODC antizyme finder, for identifying antizyme encoding sequences in spliced or intronless nucleic acid sequenes, overview
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phosphopyridoxyl-histidine
-
phosphopyridoxyl-L-tryptophan methyl ester
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phosphopyridoxyl-phenylalanine
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pyridoxyl-L-phenylalanine methyl ester
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pyridoxyl-L-tryptophan methyl ester
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vitamin C
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decreases enzyme activity in lung carcinoma NCI-H82 cells and reduces the cell viability, overview
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
antizyme inhibitor 2
-
-
-
antizyme inhibitor AzI1
AzI1 stimulates ODC activity, polyamine uptake and growth rate of enzyme ODC. AzI saves ODC from Az-induced degradation and it increases polyamine uptake. Superiority of AzI1 to ODCp in inhibiting the Az-stimulated ODC degradation. AzI, likeODCp, is degraded in a ubiquitin-dependent manner, in a reaction that does not require either interaction with Az or the integrity of its C-terminus
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ODCp
ODC-related protein or ODC paralogue, another ODCp is suggested to function as antizyme, like AzI, showing ability to increase ODC activity and inhibit Az-stimulated ODC degradation in vitro. ODCp is indeed capable of negating Az functions, as reflected by its ability to increase ODC activity and polyamine uptake and by its ability to provide growth advantage in stably transfected cells. But ODCp is less potent than AzI1 in stimulating ODC activity, polyamine uptake, and growth rate. ODCp, like AzI, is degraded in a ubiquitin-dependent manner, in a reaction that does not require either interaction with Az or the integrity of its C-terminus. Its degradation is inhibited by inactivation of a thermosensitive ubiquitin-activating enzyme, E1. And Az inhibits ODCp degradation by interfering with its ubiquitination. Interaction with Az actually stabilizes ODCp by interfering with its ubiquitination. An ODCp chimaera containing the C-terminal degradation signal of ODC is still stabilized by Az. Superiority of AzI1 to ODCp in inhibiting the Az-stimulated ODC degradation because ODCp shows lower affinity towards Az (Az1 and Az3). Human ODCp is stably overexpressed in NIH 3T3-derived cells and in HEK-293 cells, either alone or together with Az1
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ornithine decarboxylase paralogue
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additional information
-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000001
1-amino-oxy-3-aminopropane
pH 7.5, 37°C, recombinant enzyme
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.11
-
about, ODC activity in anaplastic gliomas
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.8
-
assay at
7.1
-
assay at
7.4
-
assay at
7.8
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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epithelial carcinoma cells
Manually annotated by BRENDA team
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epithelial cells
Manually annotated by BRENDA team
-
breast cancer cell line
Manually annotated by BRENDA team
-
colon adenocarcinoma cell, enzyme activity decreases upon addition of L-arginine or L-methionine to growth medium
Manually annotated by BRENDA team
colonic epithelial cells, the enzyme is expressed in ulcerative colitis and colitis-associated colon carcinogenesis
Manually annotated by BRENDA team
-
multiple enzyme forms in tumor cells
Manually annotated by BRENDA team
endometrioid cell
Manually annotated by BRENDA team
normal immortalized endometrial epithelial cells
Manually annotated by BRENDA team
-
neonatal foreskin fibroblasts
Manually annotated by BRENDA team
-
ODC expression level is positively correlated with the degree of malignity of gastric mucosa and development of gastric lesions in precancerous and cancerous gastric lesions, overview
Manually annotated by BRENDA team
-
a colon carcinoma cell line
Manually annotated by BRENDA team
M1 and M2 macrophages, human colonic macrophages express increased ODC levels in active ulcerative colitis and Crohn's disease, colitis-associated dysplasia, and colitis-associated carcinogenesis
Manually annotated by BRENDA team
-
breast epithelial cell line
Manually annotated by BRENDA team
-
breast cancer cell line
Manually annotated by BRENDA team
-
breast cancer cell line
Manually annotated by BRENDA team
-
Helicobacter pylori-infected gastric mucosa, oral administation of Lactobacillus brevis induces a decrease in gastric enzyme activity and polyamine levels
Manually annotated by BRENDA team
-
lung carcinoma cells
Manually annotated by BRENDA team
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lung carcinoma cell line
Manually annotated by BRENDA team
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neuroblastoma cell line
Manually annotated by BRENDA team
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prostate cancer cell line
Manually annotated by BRENDA team
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prostatic carcinoma cell line
Manually annotated by BRENDA team
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osteosarcoma cells
Manually annotated by BRENDA team
ODC1 is highly expressed in endometrial cancers, ncreased expression of ODC1 in late stage and in higher grade cancers
Manually annotated by BRENDA team
ODC1 is highly expressed in endometrial cancers
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
both cytoplasm and nucleus, regulatory protein antizyme-1 is mainly localized to nuceus
Manually annotated by BRENDA team
-
prostate of patients suffering from benign prostatic hyperplasia
-
Manually annotated by BRENDA team
additional information
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
physiological function
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DCOR_HUMAN
461
0
51148
Swiss-Prot
other Location (Reliability: 1)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
homodimer
active enzyme form
additional information
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
supplemental L-methionine or L-arginine induce a marked decrease in enzyme half-life concomitantly with an increase in the activity of enzyme inhibitory protein antizyme
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystal structure at 2.1 A
purified recombinant enzyme in complex with N-terminally truncated Antizyme1 (AZ1), hanging-drop vapor diffusion method, mixing of 0.001 ml of 7.7 mg/ml ODC-cAZ1 protein complex in 20 mM Tris, pH 8.5, 150 mM NaCl, and 2 mM DTT, with 0.001 ml of reservoir solution containing 0.2 M di-ammonium tartrate and 20% PEG 3350, 15°C, X-ray diffraction structure determination and analysis at 3.20 A resolution
purified recombinant His6-tagged enzyme in complex with inhibitor 1-amino-oxy-3-aminopropane or with both inhibitor and cofactor, sitting drop vapour diffusion method, 15C, 6 mg/ml protein in 25 mM HEPES, pH 7.2, 2 mM DTT, 0.5 mM EDTA, 0.02% Brij 35, 1 mM PMSF and 2 mM 1-amino-oxy-3-aminopropane, with or without 0.02 mM pyridoxal 5'-phosphate, mixed with well solution containing 25% v/v PEG 3350, 0.2 M ammonium acetate and 0.1 M Bis-Tris, pH 6.5, 2 days, needle-cluster crystals, single crystals are obtained by using a well solution containing 18% v/v PEG 3350, 0.2 M ammonium acetate, 0.1 M Bis-Tris, pH 6.5, and 3 mg/ml protein concentration, X-ray diffraction structure determination and analysis at 1.9-3.0 A resolution, molecular replacement
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A124R/N125D/Q129D/E136V/V137D/M140E
-
mutant shows very little resistance to antizyme inhibition
G316A
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the naturally occuring ODC G316A genotype is prognostic for colorectal adenoma recurrence and predicts efficacy of aspirin chemoprevention, genotyping, overview
K69A/C360A
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site-directed mutagenesis, a dominant negative mutant
Q119H/A124R/N125D/E136V/V137D/M140E
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mutant is moderately resistant to antizyme inhibition
Q119H/A124R/N125D/Q129D/E136V/M140E
-
mutant shows very little resistance to antizyme inhibition
Q119H/A124R/N125D/Q129D/E136V/V137D
-
mutant shows very little resistance to antizyme inhibition
Q119H/A124R/N125D/Q129D/E136V/V137D/M140E
-
mutations introduced to match the Trypanosoma brucei onithine decarboxylase protein sequence. Mutant is less sensitive to antizyme inhibition
Q119H/A124R/N125D/Q129D/V137D/M140E
-
mutant shows a pattern of inhibition similar to mutant Q119H/A124R/N125D/Q129D/E136V/V137D/M140E
Q119H/A124R/Q129D/E136V/V137D/M140E
-
mutant is moderately resistant to antizyme inhibition
Q119H/N125D/Q129D/E136V/V137D/M140E
-
mutant shows a pattern of inhibition similar to mutant Q119H/A124R/N125D/Q129D/E136V/V137D/M140E
Q119H/V137D
-
mutant is much less sensitive to antizyme inhibition than wild-type, pattern similar to mutant Q119H/A124R/N125D/Q129D/E136V/V137D/M140E
Q119H/V137D/M140E
-
mutant is much less sensitive to antizyme inhibition than wild-type, pattern similar to mutant Q119H/A124R/N125D/Q129D/E136V/V137D/M140E
additional information
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
antizyme 3 stabilize the enzyme
-
the wild type form of ODC has an extremely short half life of 20-30 min, and its degradation is mediated by antizyme, which binds to the monomeric form of ODC, preventing formation of the enzymatically active homodimer, and then targets ODC for degradation
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant GST-tagged enzyme from Escherichia coli strain BL21(DE3) by two times glutathione affinity chromatography and gel filtration
recombinant His6-tagged enzyme from Escherichia coli strain BLR(DE3) by nickel affinity chromatography
recombinant ODC
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
-
expression in transgenic mice expressing the human MYCN gene under the control of the rat tyrosine hydroxylase promoter
-
expression of cDNA in CHO cells
-
expression of His6-tagged enzyme in Escherichia coli strain BLR(DE3)
expression of ODC in transgenic mice or rats leading to altered, tumoric skin phenotypes, overview, a single nucleotide polymorphism occurs in intron 1 of the ODC gene, which results in increased ODC expression in response to Myc, expression in NIH-3T3 cells overexpressing eIF4E, alpha-difluoromethylornithine not only inhibits proliferation, but also reverts the transformed phenotype of NIH-3T3 cells overexpressing eIF4E
-
for transient transfection experiments, ODC cDNAs are cloned into the p3xFLAG-CMV-10 vector, transient transfections of COS-7 cells, used in the ODC activity assay, are performed.
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gene ODC, adenovirus-mediated expression, the virus containing the cytomegalovirus promoter and the green fluorescent protein gene, of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase in A-549 cells, quantitative and tissue expression analysis, G1 arrest rate, overview
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gene odc, overexpression in HL-60 cells
-
gene ODC1, quantitative real-time PCR enzyme expression analysis
gene ODC1, recombinant expression of GST-tagged enzyme in Escherichia coli strain BL21(DE3)
genotyping
-
over-expression in transgenic mouse line
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overexpression of ODC in human promyelocytic leukemia HL-60 parental cells
-
overexpression of ODC, expression analysis, overview
-
transfection of breast cancer cells with an adenoviral vector carrying antisense ODC, rAd-ODC/Ex3as, expression analysis
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
no alteration of ODC activity is detected when SH-SY5Y cells are exposed to 835 MHz/DAMPS or 1800 MHz/GSM
-
ODC mRNA expression is elevated during carcinogenesis
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
diagnostics
drug development
medicine
pharmacology
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hietala, O.A.; Yum, K.Y.; Pilon, J.; O'Donnell, K.; Holroyde, C.P.; Kline, I.; Reichard, G.A.; Litwin, S.; Gilmour, S.K.; O'Brien, T.G.
Properties of ornithine decarboxylase in human colorectal adenocarcinomas
Cancer Res.
50
2088-2094
1990
Homo sapiens
Manually annotated by BRENDA team
Steven, F.S.; Williams, L.A.; Warne, P.; Tucker, D.F.
Fluorescent location of ornithine decarboxylase employing derivatives of the specific inhibitor alpha-difluoromethyl ornithine
J. Enzyme Inhib.
3
133-143
1989
Homo sapiens
Manually annotated by BRENDA team
Halmekyto, M.; Alhonen, L.; Wahlfors, J.; Sinervirta, R.; Eloranta, T.; Janne, J.
Characterization of a transgenic mouse line over-expressing the human ornithine decarboxylase gene
Biochem. J.
15
895-898
1991
Homo sapiens
Manually annotated by BRENDA team
Bachrach, U.; Wang, Y.C.
Cancer therapy and prevention by green tea: role of ornithine decarboxylase
Amino Acids
22
1-13
2002
Homo sapiens
Manually annotated by BRENDA team
Qu, N.; Ignatenko, N.A.; Yamauchi, P.; Stringer, D.E.; Levenson, C.; Shannon, P.; Perrin, S.; Gerner, E.W.
Inhibition of human ornithine decarboxylase activity by enantiomers of difluoromethylornithine
Biochem. J.
375
465-470
2003
Homo sapiens
Manually annotated by BRENDA team
Almrud, J.J.; Oliveira, M.A.; Kern, A.D.; Grishin, N.V.; Phillips, M.A.; Hackert, M.L.
Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding
J. Mol. Biol.
295
7-16
2000
Homo sapiens (P11926), Homo sapiens
Manually annotated by BRENDA team
Wallstrom, E.L.; Persson, L.
No role of the 5' untranslated region of ornithine decarboxylase mRNA in the feedback control of the enzyme
Mol. Cell. Biochem.
197
71-78
1999
Homo sapiens
Manually annotated by BRENDA team
Chabanon, H.; Aubel, C.; Larvaron, P.; Villard, C.; Carraro, V.; Brachet, P.
Ornithine decarboxylase activity is inhibited by the polyamine precursor amino acids at the protein stability level in Caco-2 cells
Biochim. Biophys. Acta
1723
74-81
2005
Homo sapiens
Manually annotated by BRENDA team
Stabellini, G.; Brugnoli, F.; Calastrini, C.; Vizzotto, L.; Vertemati, M.; Baroni, T.; Caramelli, E.; Marinucci, L.; Pellati, A.; Bertagnolo, V.
Ornithine decarboxylase, polyamines and CD11b expression in HL-60 cells during differentiation induced by retinoic acid
Biomed. Pharmacother.
58
401-406
2004
Homo sapiens
Manually annotated by BRENDA team
Linsalata, M.; Russo, F.; Berloco, P.; Caruso, M.L.; Matteo, G.D.; Cifone, M.G.; Simone, C.D.; Ierardi, E.; Di Leo, A.
The influence of Lactobacillus brevis on ornithine decarboxylase activity and polyamine profiles in Helicobacter pylori-infected gastric mucosa
Helicobacter
9
165-172
2004
Homo sapiens
Manually annotated by BRENDA team
Schipper, R.G.; Cuijpers, V.M.; De Groot, L.H.; Thio, M.; Verhofstad, A.A.
Intracellular localization of ornithine decarboxylase and its regulatory protein, antizyme-1
J. Histochem. Cytochem.
52
1259-1266
2004
Homo sapiens
Manually annotated by BRENDA team
Levin, V.A.; Jochec, J.L.; Shantz, L.M.; Koch, P.E.; Pegg, A.E.
Tissue-based assay for ornithine decarboxylase to identify patients likely to respond to difluoromethylornithine
J. Histochem. Cytochem.
52
1467-1474
2004
Homo sapiens
Manually annotated by BRENDA team
Young, L.; Salomon, R.; Au, W.; Allan, C.; Russell, P.; Dong, Q.
Ornithine decarboxylase (ODC) expression pattern in human prostate tissues and ODC transgenic mice
J. Histochem. Cytochem.
54
223-229
2006
Homo sapiens
Manually annotated by BRENDA team
Tian, H.; Liu, X.; Zhang, B.; Sun, Q.; Sun, D.
Adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase inhibits lung cancer cell growth
Acta Biochim. Biophys. Sin.
39
423-430
2007
Homo sapiens
Manually annotated by BRENDA team
Shantz, L.M.; Levin, V.A.
Regulation of ornithine decarboxylase during oncogenic transformation: mechanisms and therapeutic potential
Amino Acids
33
213-223
2007
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Hsu, P.C.; Hour, T.C.; Liao, Y.F.; Hung, Y.C.; Liu, C.C.; Chang, W.H.; Kao, M.C.; Tsay, G.J.; Hung, H.C.; Liu, G.Y.
Increasing ornithine decarboxylase activity is another way of prolactin preventing methotrexate-induced apoptosis: crosstalk between ODC and BCL-2
Apoptosis
11
389-399
2006
Homo sapiens
Manually annotated by BRENDA team
Nilsson, T.; Bogdanovic, N.; Volkman, I.; Winblad, B.; Folkesson, R.; Benedikz, E.
Altered subcellular localization of ornithine decarboxylase in Alzheimers disease brain
Biochem. Biophys. Res. Commun.
344
640-646
2006
Homo sapiens
Manually annotated by BRENDA team
Dufe, V.T.; Ingner, D.; Heby, O.; Khomutov, A.R.; Persson, L.; Al-Karadaghi, S.
A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane
Biochem. J.
405
261-268
2007
Leishmania donovani, Homo sapiens (P11926), Homo sapiens
Manually annotated by BRENDA team
Ma, Q.; Wang, Y.; Gao, X.; Ma, Z.; Song, Z.
L-arginine reduces cell proliferation and ornithine decarboxylase activity in patients with colorectal adenoma and adenocarcinoma
Clin. Cancer Res.
13
7407-7412
2007
Homo sapiens
Manually annotated by BRENDA team
Levin, V.A.; Jochec, J.L.; Shantz, L.M.; Aldape, K.D.
Relationship between ornithine decarboxylase levels in anaplastic gliomas and progression-free survival in patients treated with DFMO-PCV chemotherapy
Int. J. Cancer
121
2279-2283
2007
Homo sapiens
Manually annotated by BRENDA team
Hoeytoe, A.; Juutilainen, J.; Naarala, J.
Ornithine decarboxylase activity is affected in primary astrocytes but not in secondary cell lines exposed to 872 MHz RF radiation
Int. J. Radiat. Biol.
83
367-374
2007
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Vanisree, A.J.; Shyamaladevi, C.S.
The effect of N-acetylcysteine in combination with vitamin C on the activity of ornithine decarboxylase of lung carcinoma cells - in vitro
Life Sci.
79
654-659
2006
Homo sapiens
Manually annotated by BRENDA team
Saunders, L.R.; Verdin, E.
Ornithine decarboxylase activity in tumor cell lines correlates with sensitivity to cell death induced by histone deacetylase inhibitors
Mol. Cancer Ther.
5
2777-2785
2006
Homo sapiens
Manually annotated by BRENDA team
Miao, X.P.; Li, J.S.; Li, H.Y.; Zeng, S.P.; Zhao, Y.; Zeng, J.Z.
Expression of ornithine decarboxylase in precancerous and cancerous gastric lesions
World J. Gastroenterol.
13
2867-2871
2007
Homo sapiens
Manually annotated by BRENDA team
Kanerva, K.; Makitie, L.T.; Pelander, A.; Heiskala, M.; Andersson, L.C.
Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase
Biochem. J.
409
187-192
2008
Homo sapiens
Manually annotated by BRENDA team
Deng, W.; Jiang, X.; Mei, Y.; Sun, J.; Ma, R.; Liu, X.; Sun, H.; Tian, H.; Sun, X.
Role of ornithine decarboxylase in breast cancer
Acta Biochim. Biophys. Sin.
40
235-243
2008
Homo sapiens
Manually annotated by BRENDA team
Snapir, Z.; Keren-Paz, A.; Bercovich, Z.; Kahana, C.
ODCp, a brain- and testis-specific ornithine decarboxylase paralogue, functions as an antizyme inhibitor, although less efficiently than AzI1
Biochem. J.
410
613-619
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Snapir, Z.; Keren-Paz, A.; Bercovich, Z.; Kahana, C.
Antizyme-3 inhibits polyamine uptake and ornithine decarboxylase (ODC) activity, but does not stimulate ODC degradation
Biochem. J.
419
99-103
2008
Homo sapiens
Manually annotated by BRENDA team
Bekaert, M.; Ivanov, I.P.; Atkins, J.F.; Baranov, P.V.
Ornithine decarboxylase antizyme finder (OAF): fast and reliable detection of antizymes with frameshifts in mRNAs
BMC Bioinformatics
9
178
2008
Homo sapiens
Manually annotated by BRENDA team
Svensson, K.J.; Welch, J.E.; Kucharzewska, P.; Bengtson, P.; Bjurberg, M.; Pahlman, S.; Ten Dam, G.B.; Persson, L.; Belting, M.
Hypoxia-mediated induction of the polyamine system provides opportunities for tumor growth inhibition by combined targeting of vascular endothelial growth factor and ornithine decarboxylase
Cancer Res.
68
9291-9301
2008
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Koomoa, D.L.; Yco, L.P.; Borsics, T.; Wallick, C.J.; Bachmann, A.S.
Ornithine decarboxylase inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma
Cancer Res.
68
9825-9831
2008
Homo sapiens
Manually annotated by BRENDA team
Rounbehler, R.J.; Li, W.; Hall, M.A.; Yang, C.; Fallahi, M.; Cleveland, J.L.
Targeting ornithine decarboxylase impairs development of MYCN-amplified neuroblastoma
Cancer Res.
69
547-553
2009
Homo sapiens
Manually annotated by BRENDA team
Hubner, R.A.; Muir, K.R.; Liu, J.F.; Logan, R.F.; Grainge, M.J.; Houlston, R.S.; Houlston, R.S.
Ornithine decarboxylase G316A genotype is prognostic for colorectal adenoma recurrence and predicts efficacy of aspirin chemoprevention
Clin. Cancer Res.
14
2303-2309
2008
Homo sapiens
Manually annotated by BRENDA team
Wu, F.; Gehring, H.
Structural requirements for novel coenzyme-substrate derivatives to inhibit intracellular ornithine decarboxylase and cell proliferation
FASEB J.
23
565-574
2008
Homo sapiens (P11926), Homo sapiens
Manually annotated by BRENDA team
Liao, Y.F.; Hung, H.C.; Hsu, P.C.; Kao, M.C.; Hour, T.C.; Tsay, G.J.; Liu, G.Y.
Ornithine decarboxylase interferes with macrophage-like differentiation and matrix metalloproteinase-9 expression by tumor necrosis factor alpha via NF-kappaB
Leuk. Res.
32
1124-1140
2008
Homo sapiens
Manually annotated by BRENDA team
Hsu, P.C.; Hung, H.C.; Liao, Y.F.; Liu, C.C.; Tsay, G.J.; Liu, G.Y.
Ornithine decarboxylase attenuates leukemic chemotherapy drugs-induced cell apoptosis and arrest in human promyelocytic HL-60 cells
Leuk. Res.
32
1530-1540
2008
Homo sapiens
Manually annotated by BRENDA team
Liao, Y.F.; Hung, H.C.; Hour, T.C.; Hsu, P.C.; Kao, M.C.; Tsay, G.J.; Liu, G.Y.
Curcumin induces apoptosis through an ornithine decarboxylase-dependent pathway in human promyelocytic leukemia HL-60 cells
Life Sci.
82
367-375
2008
Homo sapiens
Manually annotated by BRENDA team
Maekitie, L.T.; Kanerva, K.; Polvikoski, T.; Paetau, A.; Andersson, L.C.
brain neurons express ornithine decarboxylase-activating antizyme inhibitor 2 with accumulation in Alzheimers disease
Brain Pathol.
20
571-580
2010
Homo sapiens
Manually annotated by BRENDA team
Zell, J.A.; Ziogas, A.; Ignatenko, N.; Honda, J.; Qu, N.; Bobbs, A.S.; Neuhausen, S.L.; Gerner, E.W.; Anton-Culver, H.
Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival
Clin. Cancer Res.
15
6208-6216
2009
Homo sapiens
Manually annotated by BRENDA team
Grimminger, P.P.; Schneider, P.M.; Metzger, R.; Vallboehmer, D.; Danenberg, K.D.; Danenberg, P.V.; Hoelscher, A.H.; Brabender, J.
Ornithine decarboxylase mRNA expression in curatively resected non-small-cell lung cancer
Clin. Lung Cancer
11
114-119
2010
Homo sapiens
Manually annotated by BRENDA team
Brown, I.; Halliday, S.; Greig, H.; Heys, S.D.; Wallace, H.M.; Schofield, A.C.
Genetic polymorphism in ornithine decarboxylase and risk of breast cancer
Fam. Cancer
8
307-311
2009
Homo sapiens
Manually annotated by BRENDA team
Maekitie, L.T.; Kanerva, K.; Sankila, A.; Andersson, L.C.
High expression of antizyme inhibitor 2, an activator of ornithine decarboxylase in steroidogenic cells of human gonads
Histochem. Cell Biol.
132
633-638
2009
Homo sapiens
Manually annotated by BRENDA team
Geerts, D.; Koster, J.; Albert, D.; Koomoa, D.L.; Feith, D.J.; Pegg, A.E.; Volckmann, R.; Caron, H.; Versteeg, R.; Bachmann, A.S.
The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification
Int. J. Cancer
126
2012-2024
2010
Homo sapiens
Manually annotated by BRENDA team
Billaudel, B.; Taxile, M.; Poulletier de Gannes, F.; Ruffie, G.; Lagroye, I.; Veyret, B.
Effects of exposure to DAMPS and GSM signals on ornithine decarboxylase (ODC) activity: II. SH-SY5Y human neuroblastoma cells
Int. J. Radiat. Biol.
85
519-522
2009
Homo sapiens
Manually annotated by BRENDA team
Ivanov, I.P.; Firth, A.E.; Atkins, J.F.
Recurrent emergence of catalytically inactive ornithine decarboxylase homologous forms that likely have regulatory function
J. Mol. Evol.
70
289-302
2010
Aedes aegypti, Ancylostoma ceylanicum, Anopheles gambiae, Aspergillus clavatus, Aspergillus fischeri, Aspergillus fumigatus, Aspergillus terreus, Bos taurus, Botrytis cinerea, Branchiostoma floridae, Caenorhabditis briggsae, Caenorhabditis elegans, Meyerozyma guilliermondii, Canis lupus familiaris, Gallus gallus, Ciona intestinalis, Coccidioides immitis, Culex pipiens, Dictyostelium discoideum, Drosophila melanogaster, Fusarium oxysporum, Fusarium verticillioides, Homo sapiens, Hydra vulgaris, Mus musculus, Neurospora crassa, Rattus norvegicus, Takifugu rubripes, Trypanosoma brucei, Xenopus laevis, Petromyzon marinus, Parastagonospora nodorum, Uncinocarpus reesii, Tetraodon nigroviridis, Dugesia japonica, Gasterosteus aculeatus, Anolis carolinensis, Schmidtea mediterranea, Nasonia vitripennis
Manually annotated by BRENDA team
Kucharzewska, P.; Welch, J.E.; Svensson, K.J.; Belting, M.
Ornithine decarboxylase and extracellular polyamines regulate microvascular sprouting and actin cytoskeleton dynamics in endothelial cells
Exp. Cell Res.
316
2683-2691
2010
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Lange, I.; Geerts, D.; Feith, D.J.; Mocz, G.; Koster, J.; Bachmann, A.S.
Novel interaction of ornithine decarboxylase with sepiapterin reductase regulates neuroblastoma cell proliferation
J. Mol. Biol.
426
332-346
2014
Homo sapiens
Manually annotated by BRENDA team
Liu, Y.C.; Hsu, D.H.; Huang, C.L.; Liu, Y.L.; Liu, G.Y.; Hung, H.C.
Determinants of the differential antizyme-binding affinity of ornithine decarboxylase
PLoS ONE
6
e26835
2011
Homo sapiens
Manually annotated by BRENDA team
Kanerva, K.; Maekitie, L.T.; Pelander, A.; Heiskala, M.; Andersson, L.C.
Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase
Biochem. J.
409
187-192
2008
Homo sapiens
Manually annotated by BRENDA team
Snapir, Z.; Keren-Paz, A.; Bercovich, Z.; Kahana, C.
ODCp, a brain- and testis-specific ornithine decarboxylase paralogue, functions as an antizyme inhibitor, although less efficiently than AzI1
Biochem. J.
410
613-619
2008
Homo sapiens (P11926)
Manually annotated by BRENDA team
Singh, K.; Coburn, L.A.; Asim, M.; Barry, D.P.; Allaman, M.M.; Shi, C.; Washington, M.K.; Luis, P.B.; Schneider, C.; Delgado, A.G.; Piazuelo, M.B.; Cleveland, J.L.; Gobert, A.P.; Wilson, K.T.
Ornithine decarboxylase in macrophages exacerbates colitis and promotes colitis-associated colon carcinogenesis by impairing M1 immune responses
Cancer Res.
78
4303-4315
2018
Mus musculus (P00860), Homo sapiens (P11926), Homo sapiens
Manually annotated by BRENDA team
Kim, H.I.; Schultz, C.R.; Buras, A.L.; Friedman, E.; Fedorko, A.; Seamon, L.; Chandramouli, G.V.R.; Maxwell, G.L.; Bachmann, A.S.; Risinger, J.I.
Ornithine decarboxylase as a therapeutic target for endometrial cancer
PLoS ONE
12
e0189044
2017
Homo sapiens (P11926), Homo sapiens
Manually annotated by BRENDA team
Wu, D.; Kaan, H.Y.; Zheng, X.; Tang, X.; He, Y.; Vanessa Tan, Q.; Zhang, N.; Song, H.
Structural basis of ornithine decarboxylase inactivation and accelerated degradation by polyamine sensor Antizyme1
Sci. Rep.
5
14738
2015
Homo sapiens (P11926), Homo sapiens
Manually annotated by BRENDA team