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(R,S)-2-bromopropionic acid + H2O
(S)-lactic acid + (S)-2-bromopropionic acid + HCl
-
-
-
-
?
(R,S)-2-chloropropionic acid + H2O
(S)-lactic acid + (S)-2-chloropropionic acid + HCl
(S)-2-bromopropionic acid + H2O
(R)-2-hydroxypropionate + bromide
-
-
-
?
(S)-2-bromopropionic acid + H2O
(R)-2-hydroxypropionic acid + bromide
(S)-2-chlorobutyric acid + H2O
(R)-2-hydroxybutyric acid + chloride
(S)-2-chloropropionate + H2O
(R)-2-hydroxypropionate + chloride
(S)-2-chloropropionate + H2O
(R)-2-hydroxypropionic acid + chloride
(S)-2-chloropropionic acid + H2O
(R)-2-hydroxypropionate + chloride
-
-
-
?
(S)-2-chloropropionic acid + H2O
(R)-2-hydroxypropionic acid + chloride
(S)-2-chloropropionic acid + H2O
?
-
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
1,2-dichloroethane + H2O
?
2,2-dichloropropionate + H2O
propionate + HCl
2,2-dichloropropionic acid + H2O
?
-
-
-
-
?
2,2-dichloropropionic acid + H2O
propionate + 2 HCl
-
-
-
?
2,2-dichloropropionic acid + H2O
propionate + HCl
-
-
-
-
?
2,3-dibromopropionate + H2O
?
2,3-dichloropropionate + H2O
?
2,3-dichloropropionic acid + H2O
3-chlorlactic acid + HCl
2-bromoacetic acid + H2O
2-hydroxyacetate + bromide
-
-
-
?
2-bromohexadecanoate + H2O
D-2-hydroxyhexadecanoate + HBr
-
-
-
-
?
2-bromopropionic acid + H2O
?
2-chloro-3-hydroxypropionate + H2O
glycerate + HCl
2-chloro-n-butyrate + H2O
2-hydroxybutyrate + HCl
2-chloroacetic acid + H2O
2-hydroxyacetate + chloride
-
-
-
?
2-chloroacrylate + H2O
2-hydroxyacrylate + HCl
-
-
-
-
?
2-chlorobutyrate + H2O
2-hydroxybutyrate + chloride
Stutzerimonas chloritidismutans
-
low activity
-
-
?
2-chloropropionate + H2O
2-hydroxypropionate + chloride
2-chloropropionate + H2O
lactate + HCl
2-chloropropionic acid + H2O
?
2-monobromobutyrate + H2O
?
-
-
-
?
2-monochlorobutyrate + H2O
?
alpha-bromophenylacetic acid + H2O
?
-
-
-
-
?
bromoacetate + H2O
hydroxyacetate + bromide
Stutzerimonas chloritidismutans
-
highest activity
-
-
?
chloroacetate + H2O
hydroxyacetate + chloride
Stutzerimonas chloritidismutans
-
high activity
-
-
?
D-2-bromopropionate + H2O
L-2-hydroxypropionate + bromide
D-2-chloropropionate + H2O
L-2-hydroxypropionate + chloride
dichloroacetic acid + H2O
?
DL-2-bromo-n-butyrate + H2O
?
DL-2-bromobutyrate + H2O
?
DL-2-bromopropionate + H2O
?
-
-
-
-
?
DL-2-bromopropionic acid + H2O
?
-
-
-
-
?
DL-2-chlorobutyrate + H2O
?
-
-
-
-
?
DL-2-chloropropionate + H2O
?
DL-2-chloropropionate + H2O
DL-2-hydroxypropionate + chloride
Stutzerimonas chloritidismutans
-
high activity
-
-
?
DL-2-haloalkanoic acid + H2O
L-2-hydroxyalkanoic acid + D-2-hydroxyalkanoic acid + halide
iodoacetic acid + H2O
acetic acid + iodide + H+
L-2-bromobutanoate + H2O
2-hydroxybutanoate + HBr
L-2-bromohexanoate + H2O
2-hydroxyhexanoate + HBr
L-2-bromopropionate + H2O
D-2-hydroxypropionate + bromide
Stutzerimonas chloritidismutans
-
high activity
-
-
?
L-2-bromopropionate + H2O
lactate + HBr
L-2-chloropropionate + H2O
?
-
-
-
-
?
L-2-chloropropionate + H2O
D-2-hydroxypropionate + chloride
L-2-chloropropionate + H2O
D-lactate + HCl
L-2-chloropropionate + H2O
lactate + HCl
L-2-chloropropionic acid + H2O
D-2-hydroxypropionate + HCl
-
-
-
-
?
L-2-chloropropionic acid + H2O
D-2-hydroxypropionic acid + HCl
L-2-haloacid + H2O
D-2-hydroxyacid + halide
L-2-haloalkanoic acid + H2O
D-2-hydroxyalkanoic acid + halide
L-2-monochloropropionate + H2O
D-2-hydroxypropionate + HCl
monobromoacetate + H2O
glycolate + HBr
monobromoacetate + H2O
hydroxyacetate + bromide
-
-
-
-
?
monobromoacetic acid + H2O
acetic acid + bromide
monochloroacetate + H2O
glycolate + HCl
monochloroacetate + H2O
hydroxyacetate + chloride
-
-
-
-
?
monoiodoacetate + H2O
glycolate + HI
monoiodoacetate + H2O
hydroxyacetate + iodide
-
-
-
-
?
additional information
?
-
(R,S)-2-chloropropionic acid + H2O
(S)-lactic acid + (S)-2-chloropropionic acid + HCl
-
-
-
-
?
(R,S)-2-chloropropionic acid + H2O
(S)-lactic acid + (S)-2-chloropropionic acid + HCl
-
-
-
-
?
(R,S)-2-chloropropionic acid + H2O
(S)-lactic acid + (S)-2-chloropropionic acid + HCl
-
-
-
-
?
(S)-2-bromopropionic acid + H2O
(R)-2-hydroxypropionic acid + bromide
-
-
-
-
?
(S)-2-bromopropionic acid + H2O
(R)-2-hydroxypropionic acid + bromide
-
41% activity compared to monobromoacetic acid
-
-
?
(S)-2-bromopropionic acid + H2O
(R)-2-hydroxypropionic acid + bromide
-
41% activity compared to monobromoacetic acid
-
-
?
(S)-2-chlorobutyric acid + H2O
(R)-2-hydroxybutyric acid + chloride
-
below 10% activity compared to monobromoacetic acid
-
-
?
(S)-2-chlorobutyric acid + H2O
(R)-2-hydroxybutyric acid + chloride
-
below 10% activity compared to monobromoacetic acid
-
-
?
(S)-2-chloropropionate + H2O
(R)-2-hydroxypropionate + chloride
-
-
-
?
(S)-2-chloropropionate + H2O
(R)-2-hydroxypropionate + chloride
the wild-type enzyme shows no activity with the (R)-enantiomer
-
-
?
(S)-2-chloropropionate + H2O
(R)-2-hydroxypropionic acid + chloride
-
-
-
?
(S)-2-chloropropionate + H2O
(R)-2-hydroxypropionic acid + chloride
the enzyme acts exclusively on (S)-isomers
-
-
?
(S)-2-chloropropionic acid + H2O
(R)-2-hydroxypropionic acid + chloride
-
-
-
-
?
(S)-2-chloropropionic acid + H2O
(R)-2-hydroxypropionic acid + chloride
-
high activity
-
-
?
(S)-2-chloropropionic acid + H2O
(R)-2-hydroxypropionic acid + chloride
-
enantioselective
-
-
?
(S)-2-chloropropionic acid + H2O
(R)-2-hydroxypropionic acid + chloride
-
14% activity compared to monobromoacetic acid
-
-
?
(S)-2-chloropropionic acid + H2O
(R)-2-hydroxypropionic acid + chloride
-
14% activity compared to monobromoacetic acid
-
-
?
(S)-2-chloropropionic acid + H2O
(R)-2-hydroxypropionic acid + chloride
-
-
-
-
?
(S)-2-chloropropionic acid + H2O
(R)-2-hydroxypropionic acid + chloride
-
the substrate interacts strongly with Asp10, Arg41, Lys151, and Asp180
-
-
?
(S)-2-chloropropionic acid + H2O
(R)-2-hydroxypropionic acid + chloride
-
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
reaction by inversion of the configuration in a mixture of dimethylsulfoxide and buffer, but in presence of stoichiometric amounts of water proceeds without inversion of the configuration contrary to the behavior in an aqueous environment
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
reaction by inversion of the configuration in a mixture of dimethylsulfoxide and buffer, but in presence of stoichiometric amounts of water proceeds without inversion of the configuration contrary to the behavior in an aqueous environment
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
648275, 648277, 648282, 648289, 648291, 648293, 648295, 648298, 648301, 648313, 648329 -
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
enzyme of 2-chloropropionate grown cells
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
substrate specificity towards chlorinated and bromated substrates is limited to short chain monosubstituated 2-halocarboxylic acids, fluoro compounds are not converted
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
substrate specificity towards chlorinated and bromated substrates is limited to short chain monosubstituated 2-halocarboxylic acids, fluoro compounds are not converted
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
-
?
(S)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
-
-
-
-
?
1,2-dichloroethane + H2O
?
-
-
-
-
?
1,2-dichloroethane + H2O
?
-
-
-
-
?
2,2-dichloropropionate + H2O
propionate + HCl
-
53% of the activity compared to monochloroacetate
-
-
?
2,2-dichloropropionate + H2O
propionate + HCl
-
53% of the activity compared to monochloroacetate
-
-
?
2,2-dichloropropionate + H2O
propionate + HCl
-
-
-
-
?
2,3-dibromopropionate + H2O
?
-
-
-
?
2,3-dibromopropionate + H2O
?
-
-
-
-
?
2,3-dibromopropionate + H2O
?
-
-
-
?
2,3-dibromopropionate + H2O
?
-
-
-
-
?
2,3-dichloropropionate + H2O
?
-
-
-
?
2,3-dichloropropionate + H2O
?
-
-
-
?
2,3-dichloropropionic acid + H2O
3-chlorlactic acid + HCl
-
-
-
?
2,3-dichloropropionic acid + H2O
3-chlorlactic acid + HCl
-
-
-
?
2-bromopropionic acid + H2O
?
-
-
-
-
?
2-bromopropionic acid + H2O
?
-
-
-
-
?
2-bromopropionic acid + H2O
?
-
-
-
-
?
2-chloro-3-hydroxypropionate + H2O
glycerate + HCl
-
-
-
-
?
2-chloro-3-hydroxypropionate + H2O
glycerate + HCl
-
-
-
-
?
2-chloro-n-butyrate + H2O
2-hydroxybutyrate + HCl
-
-
-
-
?
2-chloro-n-butyrate + H2O
2-hydroxybutyrate + HCl
-
-
-
-
?
2-chloropropionate + H2O
2-hydroxypropionate + chloride
-
-
-
-
?
2-chloropropionate + H2O
2-hydroxypropionate + chloride
-
-
-
-
?
2-chloropropionate + H2O
lactate + HCl
-
-
-
-
?
2-chloropropionate + H2O
lactate + HCl
-
-
-
-
?
2-chloropropionate + H2O
lactate + HCl
-
-
-
-
?
2-chloropropionate + H2O
lactate + HCl
-
-
-
-
?
2-chloropropionate + H2O
lactate + HCl
-
-
-
-
?
2-chloropropionate + H2O
lactate + HCl
-
-
-
?
2-chloropropionate + H2O
lactate + HCl
-
-
-
-
?
2-chloropropionate + H2O
lactate + HCl
-
-
-
-
?
2-chloropropionate + H2O
lactate + HCl
-
-
-
-
?
2-chloropropionic acid + H2O
?
-
-
-
-
?
2-chloropropionic acid + H2O
?
-
-
-
-
?
2-monochlorobutyrate + H2O
?
-
-
-
?
2-monochlorobutyrate + H2O
?
-
-
-
?
D-2-bromopropionate + H2O
L-2-hydroxypropionate + bromide
Stutzerimonas chloritidismutans
-
high activity
-
-
?
D-2-bromopropionate + H2O
L-2-hydroxypropionate + bromide
Stutzerimonas chloritidismutans AW-1T
-
high activity
-
-
?
D-2-chloropropionate + H2O
L-2-hydroxypropionate + chloride
Stutzerimonas chloritidismutans
-
very low activity
-
-
?
D-2-chloropropionate + H2O
L-2-hydroxypropionate + chloride
Stutzerimonas chloritidismutans AW-1T
-
very low activity
-
-
?
dichloroacetate + H2O
?
-
-
-
-
?
dichloroacetate + H2O
?
-
-
-
-
?
dichloroacetate + H2O
?
-
-
-
-
?
dichloroacetate + H2O
?
-
-
-
-
?
dichloroacetate + H2O
?
-
-
-
?
dichloroacetic acid + H2O
?
-
-
-
-
?
dichloroacetic acid + H2O
?
-
-
-
-
?
dichloroacetic acid + H2O
?
-
below 10% activity compared to monobromoacetic acid
-
-
?
dichloroacetic acid + H2O
?
-
below 10% activity compared to monobromoacetic acid
-
-
?
dichloroacetic acid + H2O
?
-
-
-
-
?
dichloroacetic acid + H2O
?
low activity
-
-
?
DL-2-bromo-n-butyrate + H2O
?
-
-
-
-
?
DL-2-bromo-n-butyrate + H2O
?
-
-
-
-
?
DL-2-bromo-n-butyrate + H2O
?
-
-
-
-
?
DL-2-bromobutyrate + H2O
?
-
-
-
-
?
DL-2-bromobutyrate + H2O
?
-
-
-
-
?
DL-2-chloropropionate + H2O
?
-
-
-
-
?
DL-2-chloropropionate + H2O
?
-
-
-
-
?
DL-2-chloropropionate + H2O
?
-
-
-
-
?
DL-2-haloalkanoic acid + H2O
L-2-hydroxyalkanoic acid + D-2-hydroxyalkanoic acid + halide
-
-
-
-
?
DL-2-haloalkanoic acid + H2O
L-2-hydroxyalkanoic acid + D-2-hydroxyalkanoic acid + halide
-
-
-
-
?
fatty acids + H2O
?
-
monohaloacids, short chain length C2 to C4
-
-
?
fatty acids + H2O
?
-
monohaloacids, short chain length C2 to C4
-
-
?
iodoacetic acid + H2O
acetic acid + iodide + H+
-
-
-
-
?
iodoacetic acid + H2O
acetic acid + iodide + H+
-
best substrate
-
-
?
L-2-bromobutanoate + H2O
2-hydroxybutanoate + HBr
the enzyme catalyzes the stereospecific removal of bromide from the L-conformer but not the D-conformer
-
-
?
L-2-bromobutanoate + H2O
2-hydroxybutanoate + HBr
the enzyme catalyzes the stereospecific removal of bromide from the L-conformer but not the D-conformer
-
-
?
L-2-bromohexanoate + H2O
2-hydroxyhexanoate + HBr
the enzyme catalyzes the stereospecific removal of bromide from the L-conformer but not the D-conformer
-
-
?
L-2-bromohexanoate + H2O
2-hydroxyhexanoate + HBr
the enzyme catalyzes the stereospecific removal of bromide from the L-conformer but not the D-conformer
-
-
?
L-2-bromopropionate + H2O
lactate + HBr
the enzyme catalyzes the stereospecific removal of bromide from the L-conformer but not the D-conformer
-
-
?
L-2-bromopropionate + H2O
lactate + HBr
the enzyme catalyzes the stereospecific removal of bromide from the L-conformer but not the D-conformer
-
-
?
L-2-chloropropionate + H2O
D-2-hydroxypropionate + chloride
-
-
-
-
?
L-2-chloropropionate + H2O
D-2-hydroxypropionate + chloride
Stutzerimonas chloritidismutans
-
high activity
-
-
?
L-2-chloropropionate + H2O
D-2-hydroxypropionate + chloride
Stutzerimonas chloritidismutans AW-1T
-
high activity
-
-
?
L-2-chloropropionate + H2O
D-lactate + HCl
-
-
?
L-2-chloropropionate + H2O
D-lactate + HCl
-
-
-
?
L-2-chloropropionate + H2O
D-lactate + HCl
-
-
-
?
L-2-chloropropionate + H2O
D-lactate + HCl
-
-
-
?
L-2-chloropropionate + H2O
D-lactate + HCl
-
-
-
?
L-2-chloropropionate + H2O
D-lactate + HCl
-
-
-
?
L-2-chloropropionate + H2O
D-lactate + HCl
-
-
-
?
L-2-chloropropionate + H2O
D-lactate + HCl
-
-
-
?
L-2-chloropropionate + H2O
D-lactate + HCl
-
-
-
?
L-2-chloropropionate + H2O
D-lactate + HCl
-
-
-
?
L-2-chloropropionate + H2O
D-lactate + HCl
-
-
-
?
L-2-chloropropionate + H2O
D-lactate + HCl
-
-
-
?
L-2-chloropropionate + H2O
D-lactate + HCl
-
-
-
-
?
L-2-chloropropionate + H2O
D-lactate + HCl
-
-
-
?
L-2-chloropropionate + H2O
D-lactate + HCl
-
-
-
?
L-2-chloropropionate + H2O
D-lactate + HCl
-
-
-
-
?
L-2-chloropropionate + H2O
D-lactate + HCl
-
-
-
-
?
L-2-chloropropionate + H2O
D-lactate + HCl
-
-
-
?
L-2-chloropropionate + H2O
D-lactate + HCl
-
-
-
?
L-2-chloropropionate + H2O
D-lactate + HCl
-
-
-
?
L-2-chloropropionate + H2O
D-lactate + HCl
-
-
-
?
L-2-chloropropionate + H2O
D-lactate + HCl
-
-
-
?
L-2-chloropropionate + H2O
lactate + HCl
the enzyme catalyzes the stereospecific removal of chloride from the L-conformer but not the D-conformer
-
-
?
L-2-chloropropionate + H2O
lactate + HCl
the enzyme catalyzes the stereospecific removal of chloride from the L-conformer but not the D-conformer
-
-
?
L-2-chloropropionic acid + H2O
D-2-hydroxypropionic acid + HCl
-
-
-
-
?
L-2-chloropropionic acid + H2O
D-2-hydroxypropionic acid + HCl
-
-
-
-
?
L-2-chloropropionic acid + H2O
D-2-hydroxypropionic acid + HCl
-
-
-
-
?
L-2-haloacid + H2O
D-2-hydroxyacid + halide
Stutzerimonas chloritidismutans
-
-
-
-
?
L-2-haloacid + H2O
D-2-hydroxyacid + halide
Stutzerimonas chloritidismutans AW-1T
-
-
-
-
?
L-2-haloalkanoic acid + H2O
D-2-hydroxyalkanoic acid + halide
-
-
-
-
?
L-2-haloalkanoic acid + H2O
D-2-hydroxyalkanoic acid + halide
-
-
-
-
?
L-2-haloalkanoic acid + H2O
D-2-hydroxyalkanoic acid + halide
-
-
-
-
?
L-2-haloalkanoic acid + H2O
D-2-hydroxyalkanoic acid + halide
-
-
-
?
L-2-haloalkanoic acid + H2O
D-2-hydroxyalkanoic acid + halide
-
-
-
-
?
L-2-haloalkanoic acid + H2O
D-2-hydroxyalkanoic acid + halide
-
-
-
-
?
L-2-haloalkanoic acid + H2O
D-2-hydroxyalkanoic acid + halide
-
-
-
?
L-2-haloalkanoic acid + H2O
D-2-hydroxyalkanoic acid + halide
-
-
-
-
?
L-2-haloalkanoic acid + H2O
D-2-hydroxyalkanoic acid + halide
-
-
-
-
?
L-2-haloalkanoic acid + H2O
D-2-hydroxyalkanoic acid + halide
-
-
-
-
?
L-2-haloalkanoic acid + H2O
D-2-hydroxyalkanoic acid + halide
-
-
648275, 648277, 648282, 648286, 648289, 648291, 648293, 648295, 648298, 648301, 648305, 648313 -
-
?
L-2-haloalkanoic acid + H2O
D-2-hydroxyalkanoic acid + halide
-
-
-
-
?
L-2-haloalkanoic acid + H2O
D-2-hydroxyalkanoic acid + halide
-
-
-
-
?
L-2-haloalkanoic acid + H2O
D-2-hydroxyalkanoic acid + halide
-
-
-
-
?
L-2-haloalkanoic acid + H2O
D-2-hydroxyalkanoic acid + halide
-
-
-
-
?
L-2-haloalkanoic acid + H2O
D-2-hydroxyalkanoic acid + halide
-
-
-
?
L-2-haloalkanoic acid + H2O
D-2-hydroxyalkanoic acid + halide
-
-
-
-
?
L-2-monochloropropionate + H2O
D-2-hydroxypropionate + HCl
-
activity with D-2-monochloropropionate is 5% compared to activity with L-2-monochloropropionate
-
-
?
L-2-monochloropropionate + H2O
D-2-hydroxypropionate + HCl
-
activity with D-2-monochloropropionate is 5% compared to activity with L-2-monochloropropionate
-
-
?
monobromoacetate + H2O
glycolate + HBr
-
-
-
-
?
monobromoacetate + H2O
glycolate + HBr
-
-
-
-
?
monobromoacetate + H2O
glycolate + HBr
-
86% of the activity compared to monochloroacetate
-
-
?
monobromoacetate + H2O
glycolate + HBr
-
86% of the activity compared to monochloroacetate
-
-
?
monobromoacetate + H2O
glycolate + HBr
-
-
-
?
monobromoacetate + H2O
glycolate + HBr
-
-
-
-
?
monobromoacetate + H2O
glycolate + HBr
-
-
-
-
?
monobromoacetate + H2O
glycolate + HBr
-
-
-
-
?
monobromoacetate + H2O
glycolate + HBr
-
-
-
-
?
monobromoacetic acid + H2O
acetic acid + bromide
-
best substrate
-
-
?
monobromoacetic acid + H2O
acetic acid + bromide
-
best substrate
-
-
?
monochloroacetate + H2O
glycolate + HCl
-
-
-
-
?
monochloroacetate + H2O
glycolate + HCl
-
-
-
-
?
monochloroacetate + H2O
glycolate + HCl
-
-
-
-
?
monochloroacetate + H2O
glycolate + HCl
-
-
-
-
?
monochloroacetate + H2O
glycolate + HCl
-
-
-
-
?
monochloroacetate + H2O
glycolate + HCl
-
-
-
-
?
monochloroacetate + H2O
glycolate + HCl
-
-
-
-
?
monochloroacetate + H2O
glycolate + HCl
-
-
-
?
monochloroacetate + H2O
glycolate + HCl
-
-
-
-
?
monochloroacetate + H2O
glycolate + HCl
-
-
-
-
?
monochloroacetate + H2O
glycolate + HCl
-
-
-
?
monochloroacetate + H2O
glycolate + HCl
-
-
-
-
?
monochloroacetate + H2O
glycolate + HCl
-
-
-
-
?
monochloroacetate + H2O
glycolate + HCl
-
-
-
-
?
monochloroacetate + H2O
glycolate + HCl
-
-
-
-
?
monochloroacetate + H2O
glycolate + HCl
-
-
-
?
monochloroacetate + H2O
glycolate + HCl
-
-
-
-
?
monochloroacetate + H2O
glycolate + HCl
-
-
-
-
?
monoiodoacetate + H2O
glycolate + HI
-
-
-
-
?
monoiodoacetate + H2O
glycolate + HI
-
-
-
-
?
monoiodoacetate + H2O
glycolate + HI
-
73% of the activity compared to monochloroacetate
-
-
?
monoiodoacetate + H2O
glycolate + HI
-
73% of the activity compared to monochloroacetate
-
-
?
monoiodoacetate + H2O
glycolate + HI
-
-
-
-
?
monoiodoacetate + H2O
glycolate + HI
-
-
-
-
?
monoiodoacetate + H2O
glycolate + HI
-
-
-
-
?
additional information
?
-
-
no activity with 2-fluoropropionic acid
-
-
?
additional information
?
-
the alpha-helical structure of the enzyme plays a significant role during catalysis, while beta-sheet formation is a functional disadvantage. Analysis of environment-induced conformational and functional changes of 2-haloacid dehalogenase is informative for understanding the molecular basis of its stability and the design of the enzyme for future biotechnological applications in conjunction with its biochemical properties
-
-
-
additional information
?
-
-
the alpha-helical structure of the enzyme plays a significant role during catalysis, while beta-sheet formation is a functional disadvantage. Analysis of environment-induced conformational and functional changes of 2-haloacid dehalogenase is informative for understanding the molecular basis of its stability and the design of the enzyme for future biotechnological applications in conjunction with its biochemical properties
-
-
-
additional information
?
-
-
the enzyme reaction mechanism proceeds via an ester intermediate and a nucleophilic aspartate attacking the C-atom of the substrate to displace the halo-atom, mass spectrometral analysis of the structural changes during catalysis, overview
-
-
?
additional information
?
-
-
the enzyme reaction mechanism proceeds via an ester intermediate and a nucleophilic aspartate attacking the C-atom of the substrate to displace the halo-atom, mass spectrometral analysis of the structural changes during catalysis, overview
-
-
?
additional information
?
-
-
L-2-haloacid dehalogenase acts specifically on L-2-haloalkanoic acids to produce D-2-hydroxyalkanoic acids, which have potential applications in chemical industries and bioremediation. No activity with DL-2-fluopropionate, 3-chloropropionate, 2,2-dichloropropionate, DL-2-chloropropionamide, and DL-2-bromopropionamide
-
-
?
additional information
?
-
-
L-2-haloacid dehalogenase acts specifically on L-2-haloalkanoic acids to produce D-2-hydroxyalkanoic acids, which have potential applications in chemical industries and bioremediation. No activity with DL-2-fluopropionate, 3-chloropropionate, 2,2-dichloropropionate, DL-2-chloropropionamide, and DL-2-bromopropionamide
-
-
?
additional information
?
-
-
PH1421 is a magnesium-dependent haloacid dehalogenase phosphatase that acts on compounds closely related to 2-phosphoglycolate, the enzyme does possess 4-nitrophenyl phosphate hydrolase activity in the presence of Mg2+
-
-
?
additional information
?
-
-
PH1421 is a magnesium-dependent haloacid dehalogenase phosphatase that acts on compounds closely related to 2-phosphoglycolate, the enzyme does possess 4-nitrophenyl phosphate hydrolase activity in the presence of Mg2+
-
-
?
additional information
?
-
no activity with 2-chlorobutyric acid, trichloroacetic acid, 3-bromopropionic acid, fluoroacetate, (R)-2-chloropropionic acid, (R)-2-bromoopropionic acid, 1,2-dichloropropane, and 1-bromoheptane
-
-
?
additional information
?
-
Stutzerimonas chloritidismutans
-
no activity with 4-chlorobutyrate, 3-chloropropionate, 3-bromopropionate, 3-iodopropionate, or 2,3-dichloropropionate
-
-
-
additional information
?
-
Stutzerimonas chloritidismutans AW-1T
-
no activity with 4-chlorobutyrate, 3-chloropropionate, 3-bromopropionate, 3-iodopropionate, or 2,3-dichloropropionate
-
-
-
additional information
?
-
the enzyme is not active toward 1,4-dibromobutane
-
-
?
additional information
?
-
the enzyme is not active toward 1,4-dibromobutane
-
-
?
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Motosugi, K; Esahi, N.; Soda, K.
Enzymatic preparation of D- and L-lactic acid from racemic 2-chloropropionic acid
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26
805-806
1984
Pseudomonas sp., Pseudomonas putida, Pseudomonas sp. 113
brenda
Liu, J.Q.; Kurihara, T.; Hasan, A.K.M.Q.; Nardi-Dei, V.; Koshikawa, H.; Esaki, N.; Soda, K.
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1994
Pseudomonas sp.
brenda
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Partial purification, stereospecificity and stoichiometry of three dehalogenases from a Rhizobium species
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1988
Rhizobium sp.
-
brenda
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Bacterial 2-haloacid dehalogenases: structures and reaction mechanisms
J. Mol. Catal. B
10
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2000
Pseudomonas sp.
-
brenda
Hasan, A.K.M.Q.; Takada, H.; Koshikawa, H.; Liu, J.Q.; Kurihara, T.; Esaki, N.; Soda, K.
Two kinds of 2-halo acid dehalogeases fromm Pseudomonas sp. YL induced by 2-chloroacrylates and 2-chloropropionate
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1599-1602
1994
Pseudomonas sp.
-
brenda
Klages, M.; Krauss, S.; Lingens, F.
2-Haloacid dehalogenase from a 4-chlorobenzoate-degrading Pseudomonas spec. CBS 3
Hoppe-Seyler's Z. Physiol. Chem.
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1983
Pseudomonas sp.
brenda
Liu, J.Q.; Kurihara, T.; Miyagi, M.; Esaki, N.; Soda, K.
Reaction mechanism of L-2-haloacid dehalogenase of Pseudomonas sp. YL. Identification of Asp10 as the active site nucleophile by 18O incorporation experiments
J. Biol. Chem.
270
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1995
Pseudomonas sp., Pseudomonas sp. 113
brenda
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Purification and properties of 2-halo acid dehalogenase
Agric. Biol. Chem.
46
837-838
1982
Pseudomonas putida
-
brenda
Goldman, P.; Milne, G.W.A.; Kleister, D.B.
Carbon-halogen bond cleavage. 3. Studies on bacterial halidohydrolases
J. Biol. Chem.
243
428-434
1968
Pseudomonas sp.
brenda
Soda, K.; Kurihara, T.; Liu, J.Q.; Nardi-Dei, V.; Park, C.; Miyagi, M.; Tsunasawa, S.; Esaki, N.
Bacterial 2-haloacid dehalogenases: structures and catalytic properties
Pure Appl. Chem.
68(11)
2097-2103
1996
Xanthobacter autotrophicus, Pseudomonas sp., Rhizobium sp.
-
brenda
Liu, J.Q.; Kurihara, T.; Nardi-Dei, V.; Okamura, T.; Esaki, N.; Soda, K.
Overexpression and feasible purification of a thermostable L-2-halo acid dehalogenase of Pseudomonas sp. YL
Biodegradation
6
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1995
Pseudomonas sp.
brenda
Diez, A.; Prieto, M.I.; Alvarez, M.J.; Bautista, J.M.; Puyet, A.; Garrido-Pertierra, A.
Purification and properties of a high-affinity L-2-haloacid dehalogenase from Azotobacter sp. strain RC26
Lett. Appl. Microbiol.
23
279-282
1996
Azotobacter sp., Azotobacter sp. RC26
-
brenda
Diez, A.; Prieto, M.I.; Alvarez, M.J.; Bautista, J.M.; Garrido, A.; Puyet, A.
Improved catalytic performance of a 2-haloacid dehalogenase from Azotobacter sp. by ion-exchange immobilisation
Biochem. Biophys. Res. Commun.
220
828-833
1996
Azotobacter sp., Azotobacter sp. RC26
brenda
Ordaz., E.; Garrido-Pertierra, A.; Gallego, M.; Puyet, A.
Covalent and metal-chelate immobilization of a modified 2-haloacid dehalogenase for the enzymatic resolution of optically active chloropropionic acid
Biotechnol. Prog.
16
287-291
2000
Pseudomonas sp., Pseudomonas sp. CBS3
brenda
Tsang, J.S.H.; Sam, L.
Cloning and characterization of a cryptic haloacid dehalogenase from Burkholderia cepacia MBA4
J. Bacteriol.
181
6003-6009
1999
Burkholderia cepacia (Q51645)
brenda
Cairns, S.S.; Cornish, A.; Cooper, R.A.
Cloning, sequencing and expression in Escherichia coli of two Rhizobium sp. genes encoding haloalkonoate dehalogenases of opposite stereospecificity
Eur. J. Biochem.
235
744-749
1996
Rhizobium sp.
brenda
Asmara, W.; Murdiyatmo, U.; Baines, A.J.; Bull, A.T.; Hardman, D.J.
Protein engineering of the 2-haloacid halidohydrolase IVa from Pseudomonas cepacia MBA4
Biochem. J.
292
69-74
1993
Burkholderia cepacia, Burkholderia cepacia MBA4
-
brenda
Mrsberger, F.M.; Mller, R.; Otto, M.K.; Lingens, F.; Kulbe, K.D.
Purification and characterization of 2-halocarboxylic acid dehalogenase II from Pseudomonas spec. CBS 3
Biol. Chem. Hoppe-Seyler
372
915-922
1991
Pseudomonas sp., Pseudomonas sp. CBS3
brenda
Khler, R.; Brokamp, A.; Schwarze, R.; Reiting, R.H.; Schmidt, F.R.J.
Characteristics and DNA-sequence of a cryptic haloalkanoic acid dehalogenase from Agrobacterium tumefaciens RS5
Curr. Microbiol.
36
96-101
1998
Agrobacterium tumefaciens, Agrobacterium tumefaciens RS5
brenda
Jones, D.H.A.; Barth, P.T.; Byrom, D.; Thomas, C.M.
Nucleotide sequence of the structural gene encoding a 2-haloalkanoic acid dehalogenase of Pseudomonas putida strain AJ1 and purification of the encoded protein
J. Gen. Microbiol.
138
675-683
1992
Pseudomonas putida, Pseudomonas putida (Q52087), Pseudomonas putida AJ1 (Q52087)
brenda
Pang, B.C.M.; Tsang, J.S.H.
Mutagenic analysis of the conserved residues in dehalogenase IVa of Burkholderia cepacia MBA4
FEMS Microbiol. Lett.
204
135-140
2001
Burkholderia cepacia, Burkholderia cepacia MBA4
brenda
Van der Ploeg, J.; Van Hall, G.; Janssen, D.B.
Characterization of the haloacid dehalogenase from Xanthobacter autotrophicus GJ10 and sequencing of the dhlB gene
J. Bacteriol.
173
7925-7933
1991
Xanthobacter autotrophicus, Xanthobacter autotrophicus GJ10
brenda
Ridder, I.S.; Rozeboom, H.J.; Kalk, K.H.; Dijkstra, B.W.
Crystal structures of intermediates in the dehalogenation of haloalkanoates by L-2-haloacid dehalogenase
J. Biol. Chem.
274
30672-30678
1999
Xanthobacter autotrophicus (Q60099)
brenda
Li, Y.F.; Hata, Y.; Fujii, T.; Hisano, T.; Nishihara, M.; Kurihara, T.; Esaki, N.
Crystal structures of reaction intermediates of L-2-haloacid dehalogenase and implications for the reaction mechanism
J. Biol. Chem.
273
15035-15044
1998
Pseudomonas sp.
brenda
Ridder, I.S.; Rozeboom, H.J.; Kalk, K.H.; Janssen, D.B.; Dijkstra, B.W.
Three-dimensional structure of L-2-haloacid dehalogenase from Xanthobacter autotrophicus GJ10 complexed with the substrate-analogue formate
J. Biol. Chem.
272
33015-33022
1997
Xanthobacter autotrophicus, Xanthobacter autotrophicus GJ10
brenda
Hisano, T.; Hata, Y.; Fujii, T.; Liu, J.Q.; Kurihara, T.; Esaki, N.; Soda, K.
Crystal structures of L-2-haloacid dehalogenase from Pseudomonas sp. YL. An alpha/beta hydrolase structure that is different from the alpha/beta hydrolase fold
J. Biol. Chem.
271
20322-20330
1996
Pseudomonas sp.
brenda
Onda, M; Motosugi, K.; Nakajima, H.
A new approach for enzymatic synthesis of D-3-chlorolactic acd from racemic 2,3-dichloropropionic acid by halo acid dehalogenase
Agric. Biol. Chem.
54
3031-3033
1990
Pseudomonas putida, Rhizobium sp., Pseudomonas putida No. 109
-
brenda
Hasan, A.K.M.Q.; Motosugi, K.; Esaki, N.; Soda, K.
Total conversion of racemic 2-chloropropionic acid into D-lactate by combination of enzymic and chemical dehalogenations
J. Ferment. Bioeng.
72
481-482
1991
Pseudomonas putida
-
brenda
Vyazmensky, M.; Geresh, S.
Substrate specificity and product stereochemistry in the dehalogenation of 2-haloacids with the crude enzyme preparation from Pseudomonas putida
Enzyme Microb. Technol.
22
323-328
1998
Xanthobacter autotrophicus, Pseudomonas putida, Pseudomonas putida No. 109
-
brenda
Esaki, N.; Kurihara, T.; Li, Y.F.; Ichiyama, S.
Novel mechanism of enzymatic hydrolysis involving cyanoalanine intermediate revealed by mass spectrometric monitoring of an enzyme reaction
ICR Annual Report
7
46-47
2001
Pseudomonas putida, Pseudomonas putida YL
-
brenda
Muridiyatmo, U.; Asmara, W.; Tsang, J.S.H.; Baines, A.J.; Bull, A.T.; Hardmann, D.J.
Molecular biology of the 2-haloacid halidohydrolas IVa from Pseudomonas cepacia MBA4
Biochem. J.
284
87-93
1992
Burkholderia cepacia
-
brenda
Schneidet, B.; Mullet, R.; Fran, R.; Lingens, F.
Complete nucleotide sequences and comparison of the structural genes of two 2-haloalkanoic acid dehalogenases from Pseudomonas sp. Strain CBS3
J. Bacteriol.
173
1530-1535
1991
Pseudomonas sp.
brenda
Barth, P.T.; Bolton, L.; Thomson, J.C.
Cloning and partial sequencing of an operon encoding two Pseudomonas putida haloalkanoate dehalogenases of opposite stereospecificity
J. Bacteriol.
174
2612-2619
1992
Pseudomonas putida, Pseudomonas putida AJ1
brenda
Kawasaki, H.; Toyama, T.; Maeda, T.; Nishino, H.; Tonomura K.
Cloning and sequence analysis of a plasmid-encoded 2-haloacid dehalogenases gene from Pseudomonas putida No. 109
Biosci. Biotechnol. Biochem.
58
160-163
1994
Pseudomonas putida, Pseudomonas putida No. 109
brenda
Nardi-Dei, V.; Kurihara, T.; Okamura, T.; Liu, J.Q.; Koshijawa, H.; Ozaki, H.; Terashima, Y.; Esaki, N.; Soda, K.
Comparative studies of genes encoding thermostable L-2-halo acid dehalogenase from Pseudomonas sp. strain YL, other dehalogenases, and two related hypothetical proteins from Escherichia coli
Appl. Environ. Microbiol.
60
3375-3380
1994
Pseudomonas sp.
brenda
van der Ploeg, J.; Janssen D.B.
Sequence analysis of the upstream region of dhlB, the gene encoding haloalkanoic acid dehalogease of Xanthobacter autotrophicus GJ10
Biodegradation
6
257-263
1995
Xanthobacter autotrophicus, Xanthobacter autotrophicus GJ10
brenda
Kurihara, T.; Liu, J.Q.; Nardi-Dei, V.; Koshikawa, H.; Esaki, N.; Soda, K.
Comprehensive site-directed mutagenesis of L-2-halo acid dehalogenase to probe catalytic amino acid residues
J. Biochem.
117
1317-1322
1995
Burkholderia cepacia, Burkholderia cepacia MBA4, Moraxella sp., Moraxella sp. B, Pseudomonas putida, Pseudomonas putida AJ1, Pseudomonas putida No. 109, Pseudomonas sp., Xanthobacter autotrophicus, Xanthobacter autotrophicus GJ10
brenda
Higgins, T.P.; Hope, S.J.; Effendi, A.J.; Dawson, S.; Dancer, B.N.
Biochemical and molecular characterisation of the 2,3-dichloro-1-propanol dehalogenase and stereospecific haloalkanoic dehalogenases from a versatile Agrobacterium sp
Biodegradation
16
485-492
2005
Agrobacterium sp.
brenda
Rye, C.A.; Isupov, M.N.; Lebedev, A.A.; Littlechild, J.A.
An order-disorder twin crystal of L-2-haloacid dehalogenase from Sulfolobus tokodaii
Acta Crystallogr. Sect. D
63
926-930
2007
Sulfurisphaera tokodaii
brenda
Yamamoto, H.; Takio, K.; Sugahara, M.; Kunishima, N.
Structure of a haloacid dehalogenase superfamily phosphatase PH1421 from Pyrococcus horikoshii OT3: oligomeric state and thermoadaptation mechanism
Acta Crystallogr. Sect. D
64
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