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Information on EC 3.6.5.1 - heterotrimeric G-protein GTPase and Organism(s) Homo sapiens
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3.6.5.1 heterotrimeric G-protein GTPaseIUBMB Comments
This group comprises GTP-hydrolysing systems, where GTP and GDP alternate in binding. This group includes stimulatory and inhibitory G-proteins such as Gs, Gi, Go and Golf, targetting adenylate cyclase and/or K+ and Ca2+ channels; Gq stimulating phospholipase C; transducin activating cGMP phosphodiesterase; gustducin activating cAMP phosphodiesterase. Golf is instrumental in odour perception, transducin in vision and gustducin in taste recognition. At least 16 different alpha subunits (39-52 kDa), 5 beta subunits (36 kDa) and 12 gamma subunits (6-9 kDa) are known.
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Word Map
- 3.6.5.1
- guanine
- g-proteins
- toxin
- actin
- gdp
- cyclase
-
gtp-binding
- rhoa
- cytoskeleton
- retinal
- pertussis
- cdc42
- agonist
- rac1
- rhodopsin
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adp-ribosylation
- photoreceptors
-
protein-coupled
- alpha-subunits
- galphas
- phospholipase
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adenylyl
- camp
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endocytosis
- microtubule
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nucleotide-binding
- endosomes
- dynamin
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gdp-bound
- adenylate
- rgs
-
fission
- cholera
-
endocytic
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gpcrs
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ras-related
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dominant-negative
- cytokine
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phototransduction
- pigmentosa
- diphtheria
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ribosylation
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muscarinic
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toxin-sensitive
- opsin
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gtp-dependent
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gppnhp
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pleckstrin
-
dynamin-related
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p21-activated
- medicine
- drug development
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
gtpase, transducin, gs alpha, heterotrimeric g protein, galphaq, guanosine triphosphatase, elongation factor 2, heterotrimeric g-protein, rab1a, g alpha q, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
GTP phosphohydrolase
GTPase
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guanosine 5'-triphosphatase
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-
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guanosine triphosphatase
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phosphatase, guanosine tri-
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ribosomal GTPase
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transducin GTPase
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GTP phosphohydrolase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phosphorous acid anhydride hydrolysis
phosphorous acid anhydride hydrolysis
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-
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SYSTEMATIC NAME
IUBMB Comments
GTP phosphohydrolase (signalling)
This group comprises GTP-hydrolysing systems, where GTP and GDP alternate in binding. This group includes stimulatory and inhibitory G-proteins such as Gs, Gi, Go and Golf, targetting adenylate cyclase and/or K+ and Ca2+ channels; Gq stimulating phospholipase C; transducin activating cGMP phosphodiesterase; gustducin activating cAMP phosphodiesterase. Golf is instrumental in odour perception, transducin in vision and gustducin in taste recognition. At least 16 different alpha subunits (39-52 kDa), 5 beta subunits (36 kDa) and 12 gamma subunits (6-9 kDa) are known.
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CAS REGISTRY NUMBER
COMMENTARY
9059-32-9
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
GTP + H2O
GDP + phosphate
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intrinsic GTPase activity of transducin controls inactivation of the effector enzyme, cGMP phosphodiesterase during turnoff of the visual signal
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?
additional information
?
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-
Galpha12 and Galpha13 couple with G-protein coupled receptors, GPCRs, for various ligands, e.g. angiotensin II, endothelin, thrombin, bombesin, thromboxane A2, sphingosine-1-phosphate, and lysophosphatidic acid. The coupling specificity between G12 and G13 is usually not strict and most of these ligands can activate both G12 and G13. The RH domain of PDZ-RhoGEF interacts with Galpha13 through multiple intermolecular interfaces. One point of contact is centred on an Ile-Ile-Gly motif found N-terminal to the RGS box. This motif forms multiple contacts with the alpha helical domain of Galpha13, and is conserved in other RH-RhoGEFs. Additionally, Galpha13 interacts with an acidic stretch of residues N-terminal to the core RGS box of PDZ-RhoGEF, overview
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-
?
additional information
?
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activator/regulator protein R14-RGS by itself shows only a marginal ability to promote GTPase activity
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-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
Galpha12 and Galpha13 couple with G-protein coupled receptors, GPCRs, for various ligands, e.g. angiotensin II, endothelin, thrombin, bombesin, thromboxane A2, sphingosine-1-phosphate, and lysophosphatidic acid. The coupling specificity between G12 and G13 is usually not strict and most of these ligands can activate both G12 and G13. The RH domain of PDZ-RhoGEF interacts with Galpha13 through multiple intermolecular interfaces. One point of contact is centred on an Ile-Ile-Gly motif found N-terminal to the RGS box. This motif forms multiple contacts with the alpha helical domain of Galpha13, and is conserved in other RH-RhoGEFs. Additionally, Galpha13 interacts with an acidic stretch of residues N-terminal to the core RGS box of PDZ-RhoGEF, overview
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-
?
GTP + H2O
GDP + phosphate
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intrinsic GTPase activity of transducin controls inactivation of the effector enzyme, cGMP phosphodiesterase during turnoff of the visual signal
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Pasteurella multocida toxin
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deamidates glutamine-205 of G alphaI2 to glutamic acid, inhibits intrinsic GTPase activity, causes persistent activation of the G protein
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additional information
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tubulin binds to Gs alpha, Gi alpha1 and Gq alpha, destabilize microtubules
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Axin protein
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member of RA or E subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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Axin2 protein
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member of RA or E subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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gamma-subunit of cGMP phosphodiesterase
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accelerate GTP hydrolysis by transducin
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GRK1 protein
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member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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GRK2 protein
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member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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GRK3 protein
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member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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GRK4 protein
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member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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GRK5 protein
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member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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GRK6 protein
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member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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GRK7 protein
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member of GRK or G subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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LARG protein
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member of GEF or F subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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p115-RhoGEF protein
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member of GEF or F subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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PDZ-RhoGEF protein
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member of GEF or F subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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RGS
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retinal specific member of the RGS family accelerates GTP hydrolysis by transducin
RGS1 protein
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human B-lymphocyte, member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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RGS10 protein
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member of R12 or D subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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RGS11 protein
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member of R7 or C subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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RGS12 protein
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member of R12 or D subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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RGS13 protein
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member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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RGS17 protein
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member of RZ or A subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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RGS18 protein
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member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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RGS19 protein
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member of RZ or A subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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RGS2 protein
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human T-lymphocyte, member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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RGS20 protein
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member of RZ or A subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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RGS21 protein
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member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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RGS3 protein
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member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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RGS4 protein
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member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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RGS5 protein
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member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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RGS6 protein
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member of R7 or C subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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RGS7 protein
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member of R7 or C subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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RGS8 protein
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member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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RGS9 protein
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member of R7 or C subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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SNX13 protein
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member of SNX or H subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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SNX14 protein
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member of SNX or H subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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SNX25 protein
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member of SNX or H subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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RGS14 protein
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member of R12 or D subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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RGS14 protein
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serves as a GTPase accelerating protein for receptor-coupled heterotrimeric G proteins. RGS14 is a 60 kDa protein of the D/R12 subfamily that contains a regulator of G protein signalling (RGS) domain near its N-terminus, a central region containing a pair of tandem Ras binding domains (RBD), and a GPSM (G protein signalling modulator) domain near its C-terminus. The RGS domain of RGS14 exhibits GTPase accelerating protein activity toward Galphai/o proteins, while its GPSM domain acts as a guanine nucleotide dissociation inhibitor on Galphai1 and Galphai3. The full-length protein has a greater GTPase activating activity but a weaker inhibition of nucleotide dissociation relative to its isolated RGS and GPSM regions, respectively. These differences may be attributable to an inter-domain interaction within RGS14 that promotes the activity of the RGS domain, but simultaneously inhibits the activity of the GPSM domain. The RBD region seems to play an essential role in this regulatory activity. Various potential alternative splice variants of RGS14 are identified. Purified R14-RBD alone has no appreciable effect on the GTPase activity of M2 muscarinic receptor-stimulated Galphai3. The GPSM domain of RGS14 does not inhibit receptor-stimulated GTPase activity
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RGS16 protein
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member of R4 or B subfamily of RGS protein superfamily, RGS: regulator of G-protein signaling
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additional information
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stimulation by mouse regulator of G-protein signaling RGS18 by interaction with the alpha subunit of both Gi and Gq subfamilies, RGS18 accelerates intrinsic GTPase activity of Galphai
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additional information
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tubulin binds to G beta1gamma1, promotes microtubule stability
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
1-acylglycerophosphocholine o-acyltransferase deficiency
Ablation of ALCAT1 Mitigates Hypertrophic Cardiomyopathy through Effects on Oxidative Stress and Mitophagy.
Abetalipoproteinemia
Insights from human congenital disorders of intestinal lipid metabolism.
Acidosis
Coronary arteriolar dilation to acidosis: role of ATP-sensitive potassium channels and pertussis toxin-sensitive G proteins.
Acidosis
Effect of acidosis on PTH-dependent renal adenylate cyclase in phosphorus deprivation: role of G proteins.
Acquired Immunodeficiency Syndrome
Population genetics of Cryptosporidium meleagridis in humans and birds: evidence for cross-species transmission.
Acquired Immunodeficiency Syndrome
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Acromegaly
ACTH-independent massive bilateral adrenal disease (AIMBAD): a subtype of Cushing's syndrome with major diagnostic and therapeutic implications.
Acromegaly
Analysis of the Gs alpha gene in growth hormone-secreting pituitary adenomas by the polymerase chain reaction-direct sequencing method using paraffin-embedded tissues.
Acromegaly
G protein Gs alpha (GNAS 1), the probable candidate gene for Albright hereditary osteodystrophy, is assigned to human chromosome 20q12-q13.2.
Acromegaly
Molecular biology of growth-hormone-secreting human pituitary tumours: biochemical consequences and potential clinical significance.
Acromegaly
Study of the multiple endocrine neoplasia type 1, growth hormone-releasing hormone receptor, Gs alpha, and Gi2 alpha genes in isolated familial acromegaly.
Adenocarcinoma
ARHGAP25 Inhibits Pancreatic Adenocarcinoma Growth by Suppressing Glycolysis via AKT/mTOR Pathway.
Adenocarcinoma
Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice.
Adenocarcinoma
Significance and prognostic role of human epidermal growth factor receptor 2 and RAB1A expression in gastric cancer.
Adenocarcinoma
Suppression of the proliferation and migration of oncogenic ras-dependent cell lines, cultured in a three-dimensional collagen matrix, by flavonoid-structured molecules.
Adenocarcinoma of Lung
KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib.
Adenocarcinoma of Lung
RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer.
Adenocarcinoma of Lung
Silencing of ARL14 Gene Induces Lung Adenocarcinoma Cells to a Dormant State.
Adenocarcinoma of Lung
Systemic analyses of expression patterns and clinical features for GIMAPs family members in lung adenocarcinoma.
Adenoma
Activating mutations of the Gs alpha gene are associated with low levels of Gs alpha protein in growth hormone-secreting tumors.
Adenoma
Analysis of the Gs alpha gene in growth hormone-secreting pituitary adenomas by the polymerase chain reaction-direct sequencing method using paraffin-embedded tissues.
Adenoma
Constitutive activation of the Gs alpha protein-adenylate cyclase pathway may not be sufficient to generate toxic thyroid adenomas.
Adenoma
Constitutively active Gs alpha is associated with an increased phosphodiesterase activity in human growth hormone-secreting adenomas.
Adenoma
Expression of functional stimulatory guanine nucleotide binding protein in nonfunctioning thyroid adenomas is not correlated to adenylate cyclase activity and growth of these tumors.
Adenoma
Functioning and nonfunctioning thyroid adenomas involve different molecular pathogenetic mechanisms.
Adenoma
Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice.
Adenoma
Gs alpha--identification of a gene highly expressed by insulinoma and other endocrine tumors.
Adenoma
Heterozygous gsp mutation renders ion channels of human somatotroph adenoma cells unresponsive to growth hormone-releasing hormone.
Adenoma
Low prevalence of Gs alpha mutations in Åomatotroph adenomas of children and adolescents.
Adenoma
Molecular screening for somatic mutations in corticotropic adenomas of dogs with pituitary-dependent hyperadrenocorticism.
Adenoma
Oncogenic potential of a mutant human thyrotropin receptor expressed in FRTL-5 cells.
Adenoma
Overexpression of Gs alpha subunit in thyroid tumors bearing a mutated Gs alpha gene.
Adenoma
Rare mutations of the Gs alpha subunit gene in human endocrine tumors. Mutation detection by polymerase chain reaction-primer-introduced restriction analysis.
Adenoma, Islet Cell
Gs alpha--identification of a gene highly expressed by insulinoma and other endocrine tumors.
Adenomatous Polyposis Coli
BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes.
Adenomatous Polyposis Coli
Direct ubiquitination of beta-catenin by Siah-1 and regulation by the exchange factor TBL1.
Adenoviridae Infections
Adenovirus infection of myocardial cells induces an enhanced sensitivity to beta-adrenergic agonists by increasing the concentration of the stimulatory G-protein.
Adenoviridae Infections
Dynamin2 S-nitrosylation regulates adenovirus type 5 infection of epithelial cells.
Adrenocortical Adenoma
Rare mutations of the Gs alpha subunit gene in human endocrine tumors. Mutation detection by polymerase chain reaction-primer-introduced restriction analysis.
Adrenocortical Hyperfunction
Molecular screening for somatic mutations in corticotropic adenomas of dogs with pituitary-dependent hyperadrenocorticism.
African Swine Fever
Endosomal maturation, Rab7 GTPase and phosphoinositides in African swine fever virus entry.
African Swine Fever
Identification of genes encoding zinc finger proteins, non-histone chromosomal HMG protein homologue, and a putative GTP phosphohydrolase in the genome of Chilo iridescent virus.
Albinism, Ocular
Ebi/AP-1 suppresses pro-apoptotic genes expression and permits long-term survival of Drosophila sensory neurons.
Alopecia
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Alzheimer Disease
Alterations in the activity of adenylate cyclase and high affinity GTPase in Alzheimer's disease.
Alzheimer Disease
Area specific alterations in muscarinic stimulated low Km GTPase activity in aging and Alzheimer's disease: implications for altered signal transduction.
Alzheimer Disease
Attenuation of muscarinic receptor-G-protein interaction in Alzheimer disease.
Alzheimer Disease
Densitometric analysis of Galphao protein subunit levels from postmortem Alzheimer disease hippocampal and prefrontal cortical membranes.
Alzheimer Disease
Functional gene networks reveal distinct mechanisms segregating in migraine families.
Alzheimer Disease
G protein subunit levels in fibroblasts from familial Alzheimer's disease patients: lower levels of high molecular weight Gs alpha isoform in patients with decreased beta-adrenergic receptor stimulated cAMP formation.
Alzheimer Disease
Phosphoinositide hydrolysis, G alpha q, phospholipase C, and protein kinase C in post mortem human brain: effects of post mortem interval, subject age, and Alzheimer's disease.
Alzheimer Disease
Regionally selective alterations in G protein subunit levels in the Alzheimer's disease brain.
Alzheimer Disease
Regulation of GTPase and adenylate cyclase activity by amyloid beta-peptide and its fragments in rat brain tissue.
Alzheimer Disease
S-Nitrosylation of Dynamin-Related Protein 1 Mediates Mutant Huntingtin-Induced Mitochondrial Fragmentation and Neuronal Injury in Huntington's Disease.
Alzheimer Disease
Suppression of the kinase for elongation factor 2 alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease.
Amyotrophic Lateral Sclerosis
A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.
Amyotrophic Lateral Sclerosis
Diverse roles of Rho family GTPases in neuronal development, survival, and death.
Amyotrophic Lateral Sclerosis
SMCR8 negatively regulates AKT and MTORC1 signaling to modulate lysosome biogenesis and tissue homeostasis.
Anemia
Assessment of growth and differentiation processes in myelodysplastic syndromes by PCR analysis of Galpha16 and 5'-lipoxygenase.
Anemia, Refractory
Assessment of growth and differentiation processes in myelodysplastic syndromes by PCR analysis of Galpha16 and 5'-lipoxygenase.
Aortic Aneurysm, Abdominal
Targeting Mitochondrial Fission as a Potential Therapeutic for Abdominal Aortic Aneurysm.
Aortic Coarctation
Decompensation of pressure-overload hypertrophy in G alpha q-overexpressing mice.
Arrhythmias, Cardiac
[Animal in vivo model of arrhythmia for genes target identification for 5-amino-exo-3-azatricyclo[5.2.1.0(2,6)]decan-4-one].
Arthritis
Silencing the Expression of Ras Family GTPase Homologues Decreases Inflammation and Joint Destruction in Experimental Arthritis.
Arthritis, Rheumatoid
CTLA-4IG suppresses reactive oxygen species by preventing synovial adherent cell-induced inactivation of Rap1, a Ras family GTPASE mediator of oxidative stress in rheumatoid arthritis T cells.
Arthritis, Rheumatoid
Small GTPase RAS in multiple sclerosis - exploring the role of RAS GTPase in the etiology of multiple sclerosis.
Arthritis, Rheumatoid
The GTPase Rac regulates the proliferation and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients.
Arthritis, Rheumatoid
[Genetic polymorphisms of ARL15 and HLA-DMA are associated with rheumatoid arthritis in Han population from northwest China].
Arthus Reaction
Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation.
Asthma
Association Analysis of Member RAS Oncogene Family Gene Polymorphisms with Aspirin Intolerance in Asthmatic Patients.
Asthma
Differential coupling of G alpha q family of G-protein to muscarinic M1 receptor and neurokinin-2 receptor.
Asthma
GIMAP GTPase family genes: potential modifiers in autoimmune diabetes, asthma, and allergy.
Asthma
Increased expression of G alpha q protein in bronchial smooth muscle of mice with allergic bronchial asthma.
Astrocytoma
Gq/11 communicates with thromboxane A2 receptors in human astrocytoma cells, rabbit astrocytes and human platelets.
Astrocytoma
Isolation and characterization of a novel cDNA which identifies both neural-specific and ubiquitously expressed GS alpha mRNAs.
Astrocytoma
The regulation of RhoA at focal adhesions by StarD13 is important for astrocytoma cell motility.
Ataxia
Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease.
Ataxia
GTPase Regulator Associated with Focal Adhesion Kinase 1 (GRAF1) Immunoglobulin-Associated Ataxia and Neuropathy.
Ataxia
Impaired turnover of hyperfused mitochondria in severe axonal neuropathy due to a novel DRP1 mutation.
Ataxia Telangiectasia
Identification of genes differentially expressed between benign and osteopontin transformed rat mammary epithelial cells.
Atherosclerosis
Early growth response transcription factor EGR-1 regulates Galphaq gene in megakaryocytic cells.
Atherosclerosis
Irgm1 promotes M1 but not M2 macrophage polarization in atherosclerosis pathogenesis and development.
Atrial Fibrillation
Expression of the angiotensin II, rac GTPase activating protein 1, signal transducer and activator of transcription 3 signaling pathway in patients with permanent atrial fibrillation and rheumatic heart disease.
Autoimmune Diseases
Autoimmunity gene IRGM suppresses cGAS-STING and RIG-I-MAVS signaling to control interferon response.
Bacterial Infections
Identification of a New Class of FtsZ Inhibitors by Structure-Based Design and in Vitro Screening.
Bacterial Infections
The Rab1 GTPase of Sciaenops ocellatus modulates intracellular bacterial infection.
Blast Crisis
Structural insights into the activation of the RhoA GTPase by the lymphoid blast crisis (Lbc) oncoprotein.
Blindness
Ablation of retinal ciliopathy protein RPGR results in altered photoreceptor ciliary composition.
Blindness
Ciliopathy-associated protein CEP290 modifies the severity of retinal degeneration due to loss of RPGR.
Blindness
Gelsolin dysfunction causes photoreceptor loss in induced pluripotent cell and animal retinitis pigmentosa models.
Blindness
Leber congenital amaurosis caused by an RPGRIP1 mutation shows treatment potential.
Blindness
Phenotypic variation and genotype-phenotype discordance in canine cone-rod dystrophy with an RPGRIP1 mutation.
Blindness
Species-specific subcellular localization of RPGR and RPGRIP isoforms: implications for the phenotypic variability of congenital retinopathies among species.
Blindness
The retinitis pigmentosa GTPase regulator (RPGR) interacts with novel transport-like proteins in the outer segments of rod photoreceptors.
Blister
Heterotrimeric G protein signaling governs the cortical stability during apical constriction in Drosophila gastrulation.
Blister
Involvement of small GTPases Rho and Rac in the invasion of rat ascites hepatoma cells.
Bone Diseases
Periostin, a novel marker of intramembranous ossification, is expressed in fibrous dysplasia and in c-Fos-overexpressing bone lesions.
Bone Diseases, Metabolic
Continuous activation of G alpha q in osteoblasts results in osteopenia through impaired osteoblast differentiation.
Bone Resorption
Calmodulin interacts with Rab3D and modulates osteoclastic bone resorption.
Bone Resorption
Opposing roles of hematopoietic-specific small GTPase Rac2 and the guanine nucleotide exchange factor Vav1 in osteoclast differentiation.
Bradycardia
G-protein signaling participates in the development of diabetic cardiomyopathy.
Brain Diseases
Clinical Assessments and EEG Analyses of Encephalopathies Associated With Dynamin-1 Mutation.
Brain Diseases
De novo missense variant in the GTPase effector domain (GED) of DNM1L leads to static encephalopathy and seizures.
Brain Injuries
[Role of immune-related GTPase M1 in cortical neurons autophagy of mice with sepsis-induced brain injury].
Brain Neoplasms
Brain tumors predominantly express the neurofibromatosis type 1 gene transcripts containing the 63 base insert in the region coding for GTPase activating protein-related domain.
Breast Neoplasms
A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells.
Breast Neoplasms
Aberrant expression of Rab1A and its prognostic significance in human colorectal cancer.
Breast Neoplasms
Abnormal expression of Rap2A as a prognostic marker for human breast cancer.
Breast Neoplasms
ADP-ribosylation factor 1 expression regulates epithelial-mesenchymal transition and predicts poor clinical outcome in triple-negative breast cancer.
Breast Neoplasms
ARF1 controls Rac1 signaling to regulate migration of MDA-MB-231 invasive breast cancer cells.
Breast Neoplasms
ARF1 regulates adhesion of MDA-MB-231 invasive breast cancer cells through formation of focal adhesions.
Breast Neoplasms
ARF1 regulates the Rho/MLC pathway to control EGF-dependent breast cancer cell invasion.
Breast Neoplasms
Breast cancer cell migration is regulated through junctional adhesion molecule-A-mediated activation of Rap1 GTPase.
Breast Neoplasms
Circadian locomotor output cycles kaput affects the proliferation and migration of breast cancer cells by regulating the expression of E-cadherin via IQ motif containing GTPase activating protein 1.
Breast Neoplasms
Cooperative interaction between the MUC1-C oncoprotein and the Rab31 GTPase in estrogen receptor-positive breast cancer cells.
Breast Neoplasms
Dichotomous roles of claudins as tumor promoters or suppressors: lessons from knockout mice.
Breast Neoplasms
Ectopic expression of Rsu-1 results in elevation of p21CIP and inhibits anchorage-independent growth of MCF7 breast cancer cells.
Breast Neoplasms
Essential role of the cancer stem/progenitor cell marker nucleostemin for indole-3-carbinol anti-proliferative responsiveness in human breast cancer cells.
Breast Neoplasms
Expression of bcl-2, c-erbB-2, p53, and p21 (waf1-cip1) protein in thyroid carcinomas.
Breast Neoplasms
Farnesyl transferase inhibitor treatment of breast cancer cells leads to altered RhoA and RhoC GTPase activity and induces a dormant phenotype.
Breast Neoplasms
Focus on Cdc42 in Breast Cancer: New Insights, Target Therapy Development and Non-Coding RNAs.
Breast Neoplasms
G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion.
Breast Neoplasms
G12 signaling through c-Jun NH2-terminal kinase promotes breast cancer cell invasion.
Breast Neoplasms
Gonadotropin-releasing hormone receptor activates GTPase RhoA and inhibits cell invasion in the breast cancer cell line MDA-MB-231.
Breast Neoplasms
GPR116, an Adhesion G-Protein-Coupled Receptor, Promotes Breast Cancer Metastasis via the G?q-p63RhoGEF-Rho GTPase Pathway.
Breast Neoplasms
High glucose levels promote the proliferation of breast cancer cells through GTPases.
Breast Neoplasms
Immunohistochemical evalulation of activated Ras and Rac1 as potential downstream effectors of aquaporin-5 in breast cancer in vivo.
Breast Neoplasms
Inhibition of RAB1A suppresses epithelial-mesenchymal transition and proliferation of triple-negative breast cancer cells.
Breast Neoplasms
IQGAP3 Overexpression Correlates With Poor Prognosis and Radiation Therapy Resistance in Breast Cancer.
Breast Neoplasms
Knockdown of Ran GTPase expression inhibits the proliferation and migration of breast cancer cells.
Breast Neoplasms
Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state.
Breast Neoplasms
MicroRNA-22 Suppresses Breast Cancer Cell Growth and Increases Paclitaxel Sensitivity by Targeting NRAS.
Breast Neoplasms
miR?139?3p suppresses the invasion and migration properties of breast cancer cells by targeting RAB1A.
Breast Neoplasms
Nano-encapsulation of a novel anti-Ran-GTPase peptide for blockade of regulator of chromosome condensation 1 (RCC1) function in MDA-MB-231 breast cancer cells.
Breast Neoplasms
Overexpression of Ran GTPase Components Regulating Nuclear Export, but not Mitotic Spindle Assembly, Marks Chromosome Instability and Poor Prognosis in Breast Cancer.
Breast Neoplasms
p38{gamma} promotes breast cancer cell motility and metastasis through regulation of RhoC GTPase, cytoskeletal architecture, and a novel leading edge behavior.
Breast Neoplasms
Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT.
Breast Neoplasms
Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation.
Breast Neoplasms
RASAL2 down-regulation in ovarian cancer promotes epithelial-mesenchymal transition and metastasis.
Breast Neoplasms
Reduced expression of Snail decreases breast cancer cell motility by downregulating the expression and inhibiting the activity of RhoA GTPase.
Breast Neoplasms
Reduced RhoA expression enhances breast cancer metastasis with a concomitant increase in CCR5 and CXCR4 chemokines signaling.
Breast Neoplasms
Regulation of growth and tumorigenicity of breast cancer cells by the low molecular weight GTPase Rad and nm23.
Breast Neoplasms
Signals and pathways regulating nucleolar retention of novel putative nucleolar GTPase NGP-1(GNL-2).
Breast Neoplasms
Target-Driven Design of a Coumarinyl Chalcone Scaffold Based Novel EF2 Kinase Inhibitor Suppresses Breast Cancer Growth In Vivo.
Breast Neoplasms
TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia.
Breast Neoplasms
The anti-psychotic drug pimozide is a novel chemotherapeutic for breast cancer.
Breast Neoplasms
The FTO/miR-181b-3p/ARL5B signaling pathway regulates cell migration and invasion in breast cancer.
Breast Neoplasms
The Galphai and Galphaq proteins mediate the effects of melatonin on steroid/thyroid hormone receptor transcriptional activity and breast cancer cell proliferation.
Breast Neoplasms
The R-Ras GTPase mediates cross talk between estrogen and insulin signaling in breast cancer cells.
Breast Neoplasms
The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation.
Breast Neoplasms
The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling.
Breast Neoplasms
The UPR Transducer IRE1 Promotes Breast Cancer Malignancy by Degrading Tumor Suppressor microRNAs.
Breast Neoplasms
Therapeutic IMC-C225 antibody inhibits breast cancer cell invasiveness via Vav2-dependent activation of RhoA GTPase.
Breast Neoplasms
Transducin (?)-like 1 X-linked receptor 1 promotes proliferation and tumorigenicity in human breast cancer via activation of beta-catenin signaling.
Breast Neoplasms
[Effect of GTPase activating protein Git2 on metastasis in breast cancer].
Burkitt Lymphoma
Detection of Chromosomal Translocation in Hematologic Malignancies by a Novel DNA-Based Looped Ligation Assay (LOLA).
Carcinogenesis
A PI3K/AKT Scaffolding Protein, IQ Motif-Containing GTPase Associating Protein 1 (IQGAP1), Promotes Head and Neck Carcinogenesis.
Carcinogenesis
A transcriptional cross-talk between RhoA and c-Myc inhibits the RhoA/Rock-dependent cytoskeleton.
Carcinogenesis
Analysis of the Gs alpha gene in growth hormone-secreting pituitary adenomas by the polymerase chain reaction-direct sequencing method using paraffin-embedded tissues.
Carcinogenesis
ARHGAP25 Inhibits Pancreatic Adenocarcinoma Growth by Suppressing Glycolysis via AKT/mTOR Pathway.
Carcinogenesis
c-Fos-dependent induction of the small ras-related GTPase Rab11a in skin carcinogenesis.
Carcinogenesis
Conformational resolution of nucleotide cycling and effector interactions for multiple small GTPases determined in parallel.
Carcinogenesis
CRMP5-associated GTPase (CRAG) Is a Candidate Driver Gene for Colorectal Cancer Carcinogenesis.
Carcinogenesis
Dampened VEPH1 activates mTORC1 signaling by weakening the TSC1/TSC2 association in hepatocellular carcinoma.
Carcinogenesis
Downregulation of miR?143 modulates KRAS expression in colorectal carcinoma cells.
Carcinogenesis
Effect of increased expression of both ras-related C3 botulinum toxin substrate 1 and p21-activated kinase 1 in patients with N0M0 upper urinary tract urothelial carcinoma and cancer-free surgical margins.
Carcinogenesis
Gs alpha mutation may be uncommon in patients with multiple endocrine neoplasia type 1.
Carcinogenesis
Hepatic Rac1 GTPase contributes to liver-mediated basal immune homeostasis and LPS-induced endotoxemia.
Carcinogenesis
Hepatitis B Virus X Protein Stimulates Proliferation, Wound Closure and Inhibits Apoptosis of HuH-7 Cells via CDC42.
Carcinogenesis
High expression of immunity-related GTPase family M protein in glioma promotes cell proliferation and autophagy protein expression.
Carcinogenesis
High frequency of activated K-ras codon 15 mutant in colorectal carcinomas from Taiwanese patients.
Carcinogenesis
Induction of human microsomal prostaglandin E synthase 1 by activated oncogene RhoA GTPase in A549 human epithelial cancer cells.
Carcinogenesis
Induction of MAP Kinase Phosphatase 3 through Erk/MAP Kinase Activation in Three Oncogenic Ras (H-, K- and N-Ras) Expressing NIH/3T3 Mouse Embryonic Fibroblasts.
Carcinogenesis
Influenza Virus Induces Cholesterol-Enriched Endocytic Recycling Compartments for Budozone Formation via Cell Cycle-Independent Centrosome Maturation.
Carcinogenesis
Low incidence of the stimulatory G protein alpha-subunit mutations in autonomously functioning thyroid adenomas in Japan.
Carcinogenesis
Low prevalence of Gs alpha mutations in Åomatotroph adenomas of children and adolescents.
Carcinogenesis
Molecular dynamics simulations of Gly-12-->Val mutant of p21(ras): dynamic inhibition mechanism.
Carcinogenesis
Molecular screening for somatic mutations in corticotropic adenomas of dogs with pituitary-dependent hyperadrenocorticism.
Carcinogenesis
Odontogenic myxomas are not associated with activating mutations of the Gs alpha gene.
Carcinogenesis
Oncogenic potential of a mutant human thyrotropin receptor expressed in FRTL-5 cells.
Carcinogenesis
Overexpression of IQGAP1 promotes the angiogenesis of esophageal squamous cell carcinoma through the AKT and ERK?mediated VEGF?VEGFR2 signaling pathway.
Carcinogenesis
Potent farnesyltransferase inhibitor ABT-100 abrogates acute allograft rejection.
Carcinogenesis
Real-Time In-Cell NMR Reveals the Intracellular Modulation of GTP-Bound Levels of RAS.
Carcinogenesis
Relative molecular similarity in selected chemical carcinogens and the nucleoside triphosphate chain.
Carcinogenesis
Reversible SUMOylation of TBL1-TBLR1 Regulates ?-Catenin-Mediated Wnt Signaling.
Carcinogenesis
Systemic Delivery of MicroRNA-101 Potently Inhibits Hepatocellular Carcinoma In Vivo by Repressing Multiple Targets.
Carcinogenesis
The arginine finger of RasGAP helps Gln-61 align the nucleophilic water in GAP-stimulated hydrolysis of GTP.
Carcinogenesis
The long noncoding RNA KTN1-AS1 promotes bladder cancer tumorigenesis via KTN1 cis-activation and the consequent initiation of Rho GTPase-mediated signaling.
Carcinogenesis
The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation.
Carcinogenesis
The RAS-related GTPase RHOB confers resistance to EGFR-tyrosine kinase inhibitors in non-small-cell lung cancer via an AKT-dependent mechanism.
Carcinogenesis
The thyrotropin receptor (TSH-R) is not an oncogene for thyroid tumors: structural studies of the TSH-R and the alpha-subunit of Gs in human thyroid neoplasms.
Carcinogenesis
Transducin (?)-like 1 X-linked receptor 1 correlates with clinical prognosis and clinicopathological characteristics in human solid carcinomas.
Carcinogenesis
Transducin (?)-like 1 X-linked receptor 1 promotes gastric cancer progression via the ERK1/2 pathway.
Carcinogenesis
Transducin ?-like 1 X-linked receptor 1 suppresses cisplatin sensitivity in nasopharyngeal carcinoma via activation of NF-?B pathway.
Carcinogenesis
Tyr42 phosphorylation of RhoA GTPase promotes tumorigenesis through nuclear factor (NF)-?B.
Carcinoid Tumor
Gs alpha--identification of a gene highly expressed by insulinoma and other endocrine tumors.
Carcinoid Tumor
Mechanical stimulation activates Galphaq signaling pathways and 5-hydroxytryptamine release from human carcinoid BON cells.
Carcinoma
Amplified expression of p21 ras protein in hormone-dependent mammary carcinomas of humans and rodents.
Carcinoma
Differential partitioning of Galphai1 with the cellular microtubules: a possible mechanism of development of Taxol resistance in human ovarian carcinoma cells.
Carcinoma
Downregulation of RhoB GTPase confers resistance to cisplatin in human laryngeal carcinoma cells.
Carcinoma
Growth rate dependence of differential incorporation of a guanosine triphosphate photoaffinity probe into the alpha subunit of a guanine nucleotide binding protein, Gs, from metastatic variants of B16 melanoma cells.
Carcinoma
Gs alpha--identification of a gene highly expressed by insulinoma and other endocrine tumors.
Carcinoma
GTPase Regulator Associated with Focal Adhesion Kinase 1 (GRAF1) Immunoglobulin-Associated Ataxia and Neuropathy.
Carcinoma
High expression of Ran GTPase is associated with local invasion and metastasis of human clear cell renal cell carcinoma.
Carcinoma
Modulation of RhoA GTPase Activity Sensitizes Human Cervix Carcinoma Cells to ?-Radiation by Attenuating DNA Repair Pathways.
Carcinoma
Overexpression of Septin1: Possible contribution to the development of oral cancer.
Carcinoma
Phenotypic analysis of ovarian carcinoma: polypeptide expression in benign, borderline and malignant tumors.
Carcinoma
RhoC GTPase expression as a potential marker of lymph node metastasis in squamous cell carcinomas of the head and neck.
Carcinoma
Shenqi Fuzheng Injection Reverses Cisplatin Resistance through Mitofusin-2-Mediated Cell Cycle Arrest and Apoptosis in A549/DDP Cells.
Carcinoma
Somatic Mutations in LRRK2 Identify a Subset of Invasive Mammary Carcinomas Associated with High Mutation Burden.
Carcinoma
The peptide recognized by HLA-A68.2-restricted, squamous cell carcinoma of the lung-specific cytotoxic T lymphocytes is derived from a mutated elongation factor 2 gene.
Carcinoma
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Carcinoma
Transducin (?)-like 1 X-linked receptor 1 correlates with clinical prognosis and clinicopathological characteristics in human solid carcinomas.
Carcinoma
[Effects of RAB1A on the proliferation, invasion, and metastasis of tongue squamous cell carcinoma cells].
Carcinoma, Embryonal
c-Jun amino-terminal kinase is regulated by Galpha12/Galpha13 and obligate for differentiation of P19 embryonal carcinoma cells by retinoic acid.
Carcinoma, Embryonal
G alpha 13 signals via p115RhoGEF cascades regulating JNK1 and primitive endoderm formation.
Carcinoma, Hepatocellular
A novel KLF6-Rho GTPase axis regulates hepatocellular carcinoma cell migration and dissemination.
Carcinoma, Hepatocellular
Aberrant amino acid signaling promotes growth and metastasis of hepatocellular carcinomas through Rab1A-dependent activation of mTORC1 by Rab1A.
Carcinoma, Hepatocellular
Aberrant expression of Rab1A and its prognostic significance in human colorectal cancer.
Carcinoma, Hepatocellular
Clinical significance of mitofusin-2 and its signaling pathways in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Concanavalin A/IFN-gamma triggers autophagy-related necrotic hepatocyte death through IRGM1-mediated lysosomal membrane disruption.
Carcinoma, Hepatocellular
DLC1 suppresses distant dissemination of human hepatocellular carcinoma cells in nude mice through reduction of RhoA GTPase activity, actin cytoskeletal disruption and down-regulation of genes involved in metastasis.
Carcinoma, Hepatocellular
DNA methylation-mediated silencing of matricellular protein dermatopontin promotes hepatocellular carcinoma metastasis by ?3?1 integrin-Rho GTPase signaling.
Carcinoma, Hepatocellular
Expression analysis and implication of Rab1A in gastrointestinal relevant tumor.
Carcinoma, Hepatocellular
MicroRNA-1178-3p suppresses the growth of hepatocellular carcinoma by regulating transducin (beta)-like 1 X-linked receptor 1.
Carcinoma, Hepatocellular
miR-15b-5p induces endoplasmic reticulum stress and apoptosis in human hepatocellular carcinoma, both in vitro and in vivo, by suppressing Rab1A.
Carcinoma, Hepatocellular
miR-634 exhibits anti-tumor activities toward hepatocellular carcinoma via Rab1A and DHX33.
Carcinoma, Hepatocellular
Ras Homolog Family Member F, Filopodia Associated Promotes Hepatocellular Carcinoma Metastasis by Altering the Metabolic Status of Cancer Cells Through RAB3D.
Carcinoma, Hepatocellular
Transducin (Beta)-Like 1 X-Linked Receptor 1 Correlates with Clinical Prognosis and Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Ubiquitin-specific protease 2a promotes hepatocellular carcinoma progression via deubiquitination and stabilization of RAB1A.
Carcinoma, Intraductal, Noninfiltrating
Downregulation of Rap1Gap: A Switch from DCIS to Invasive Breast Carcinoma via ERK/MAPK Activation.
Carcinoma, Non-Small-Cell Lung
AGO2 promotes tumor progression in KRAS-driven mouse models of non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis.
Carcinoma, Non-Small-Cell Lung
In Silico Screening of Mutated K-Ras Inhibitors from Malaysian Typhonium flagelliforme for Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer.
Carcinoma, Non-Small-Cell Lung
Novel transmembrane GTPase of non-small cell lung cancer identified by mRNA differential display.
Carcinoma, Non-Small-Cell Lung
Prognostic value of KRAS/TP53/PIK3CA in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Rab8 GTPase regulates Klotho-mediated inhibition of cell growth and progression by directly modulating its surface expression in human non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Ran GTPase induces EMT and enhances invasion in non-small cell lung cancer cells through activation of PI3K-AKT pathway.
Carcinoma, Ovarian Epithelial
An essential role for Ran GTPase in epithelial ovarian cancer cell survival.
Carcinoma, Ovarian Epithelial
Endothelin-1/endothelin A receptor axis activates RhoA GTPase in epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
Evaluation of core serous epithelial ovarian cancer genes as potential prognostic markers and indicators of the underlying molecular mechanisms using an integrated bioinformatics analysis.
Carcinoma, Ovarian Epithelial
Rab25 is responsible for phosphoinositide 3-kinase/AKT?mediated cisplatin resistance in human epithelial ovarian cancer cells.
Carcinoma, Papillary
Overexpression of Gs alpha subunit in thyroid tumors bearing a mutated Gs alpha gene.
Carcinoma, Renal Cell
High expression of Ran GTPase is associated with local invasion and metastasis of human clear cell renal cell carcinoma.
Carcinoma, Squamous Cell
GTPase Regulator Associated with Focal Adhesion Kinase 1 (GRAF1) Immunoglobulin-Associated Ataxia and Neuropathy.
Carcinoma, Squamous Cell
Mutational analyses of candidate genes in human squamous cell carcinomas.
Carcinoma, Squamous Cell
RhoC GTPase expression as a potential marker of lymph node metastasis in squamous cell carcinomas of the head and neck.
Carcinoma, Squamous Cell
The peptide recognized by HLA-A68.2-restricted, squamous cell carcinoma of the lung-specific cytotoxic T lymphocytes is derived from a mutated elongation factor 2 gene.
Carcinoma, Squamous Cell
[Effects of RAB1A on the proliferation, invasion, and metastasis of tongue squamous cell carcinoma cells].
Cardiomegaly
Cardiac-directed expression of adenylyl cyclase reverses electrical remodeling in cardiomyopathy.
Cardiomegaly
Cardiac-specific overexpression of Galphaq alters excitation-contraction coupling in isolated cardiac myocytes.
Cardiomegaly
Diacylglycerol kinase zeta rescues G alpha q-induced heart failure in transgenic mice.
Cardiomegaly
Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure.
Cardiomegaly
GTPase Activating Protein (Sh3 Domain) Binding Protein 1 Regulates the Processing of MicroRNA-1 during Cardiac Hypertrophy.
Cardiomegaly
Identification of transcription factor E3 (TFE3) as a receptor-independent activator of G{alpha}16: Gene regulation by nuclear G{alpha} subunit and its activator.
Cardiomegaly
Increased myocardial Rab GTPase expression: a consequence and cause of cardiomyopathy.
Cardiomegaly
Inhibition of Rho-kinase by fasudil attenuated angiotensin II-induced cardiac hypertrophy in apolipoprotein E deficient mice.
Cardiomegaly
PKC translocation without changes in Galphaq and PLC-beta protein abundance in cardiac hypertrophy and failure.
Cardiomegaly
Protein kinase Calpha negatively regulates systolic and diastolic function in pathological hypertrophy.
Cardiomegaly
RhoA signaling in cardiomyocytes protects against stress-induced heart failure but facilitates cardiac fibrosis.
Cardiomegaly
Signal transduction during cardiac hypertrophy: the role of G alpha q, PLC beta I, and PKC.
Cardiomyopathies
Adenovirus infection of myocardial cells induces an enhanced sensitivity to beta-adrenergic agonists by increasing the concentration of the stimulatory G-protein.
Cardiomyopathies
An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice.
Cardiomyopathies
Cellular and molecular alterations in the beta adrenergic system with cardiomyopathy induced by tachycardia.
Cardiomyopathies
Increased messenger RNA level of the inhibitory G protein alpha subunit Gi alpha-2 in human end-stage heart failure.
Cardiomyopathies
Increased myocardial Rab GTPase expression: a consequence and cause of cardiomyopathy.
Cardiomyopathies
Messenger RNA levels of guanine nucleotide-binding proteins are reduced in the ventricle of cardiomyopathic hamsters.
Cardiomyopathies
Molecular mechanism of hypertrophied failing heart--abnormalities of the diastolic properties and contractility.
Cardiomyopathies
Propranolol prevents enhanced stress signaling in Gs alpha cardiomyopathy: potential mechanism for beta-blockade in heart failure.
Cardiomyopathy, Dilated
Detection of mitochondrial dysfunction by EPR technique in mouse model of dilated cardiomyopathy.
Cardiomyopathy, Dilated
Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development.
Cardiomyopathy, Dilated
Improvement of cholera toxin-catalyzed ADP-ribosylation by endogenous ADP-ribosylation factor from bovine brain provides evidence for an unchanged amount of Gs alpha in failing human myocardium.
Cardiomyopathy, Dilated
Increased messenger RNA level of the inhibitory G protein alpha subunit Gi alpha-2 in human end-stage heart failure.
Cardiomyopathy, Dilated
Late-stage alterations in myofibrillar contractile function in a transgenic mouse model of dilated cardiomyopathy (Tgalphaq*44).
Cardiomyopathy, Dilated
TFEB Overexpression, Not mTOR Inhibition, Ameliorates RagCS75Y Cardiomyopathy.
Cardiomyopathy, Dilated
Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways.
Cardiomyopathy, Hypertrophic, Familial
Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy.
Cardiovascular Diseases
Roles of accessory proteins for heterotrimeric g-protein in the development of cardiovascular diseases.
Carney Complex
Sporadic cardiac myxomas and tumors from patients with Carney complex are not associated with activating mutations of the Gs alpha gene.
Cataract
Mutations of RagA GTPase in mTORC1 Pathway Are Associated with Autosomal Dominant Cataracts.
Cell Transformation, Neoplastic
Identification of functional cooperative mutations of GNAO1 in human acute lymphoblastic leukemia.
Cerebellar Ataxia
Two new cases of anti-Ca (anti-ARHGAP26/GRAF) autoantibody-associated cerebellar ataxia.
Cerebral Infarction
Development of a cell transducible RhoA inhibitor TAT-C3 transferase and its encapsulation in biocompatible microspheres to promote survival and enhance regeneration of severed neurons.
Cerebral Infarction
Fuyuan Xingnao Decoction Promotes Angiogenesis Through the Rab1/AT1R Pathway in Diabetes Mellitus Complicated With Cerebral Infarction.
Cervical Intraepithelial Neoplasia
RAP1 GTPase overexpression is associated with cervical intraepithelial neoplasia.
Charcot-Marie-Tooth Disease
A cohort study of MFN2 mutations and phenotypic spectrums in Charcot-Marie-Tooth disease 2A patients.
Charcot-Marie-Tooth Disease
A novel mitofusin 2 mutation causes canine fetal-onset neuroaxonal dystrophy.
Charcot-Marie-Tooth Disease
Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin.
Charcot-Marie-Tooth Disease
Rab7 mutants associated with Charcot-Marie-Tooth disease exhibit enhanced NGF-stimulated signaling.
Cholangiocarcinoma
Hypoxia-mediated miR-212-3p downregulation enhances progression of intrahepatic cholangiocarcinoma through upregulation of Rab1a.
Cholera
A novel guanine nucleotide-binding protein coupled to the alpha 1-adrenergic receptor. II. Purification, characterization, and reconstitution.
Cholera
A protein kinase C inhibitor, staurosporine, activates phospholipase D via a pertussis toxin-sensitive GTP-binding protein in rabbit peritoneal neutrophils.
Cholera
Activating mutations of the Gs alpha gene are associated with low levels of Gs alpha protein in growth hormone-secreting tumors.
Cholera
Activation of ADP-ribosylation factor by Golgi membranes. Evidence for a brefeldin A- and protease-sensitive activating factor on Golgi membranes.
Cholera
Activation of Escherichia coli heat-labile enterotoxins by native and recombinant adenosine diphosphate-ribosylation factors, 20-kD guanine nucleotide-binding proteins.
Cholera
Activation of FSH-responsive adenylate cyclase by staurosporine: role for protein phosphorylation in gonadotropin receptor desensitization.
Cholera
Activation of the alpha subunit of Gs in intact cells alters its abundance, rate of degradation, and membrane avidity.
Cholera
Activation of toxin ADP-ribosyltransferases by the family of ADP-ribosylation factors.
Cholera
ADP-ribosylation factors: a family of approximately 20-kDa guanine nucleotide-binding proteins that activate cholera toxin.
Cholera
ADP-ribosylation of thylakoid membrane polypeptides by cholera toxin is correlated with inhibition of thylakoid GTPase activity and protein phosphorylation.
Cholera
ADP-ribosylation of transducin by islet-activation protein. Identification of asparagine as the site of ADP-ribosylation.
Cholera
ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal photoreceptors.
Cholera
Agonist-dependent, cholera toxin-catalyzed ADP-ribosylation of pertussis toxin-sensitive G-proteins following transfection of the human alpha 2-C10 adrenergic receptor into rat 1 fibroblasts. Evidence for the direct interaction of a single receptor with two pertussis toxin-sensitive G-proteins, Gi2 and Gi3.
Cholera
Alterations in the stimulatory G protein of the rat liver after partial hepatectomy.
Cholera
Altered guanine nucleoside triphosphate binding to transducin by cholera toxin-catalysed ADP-ribosylation.
Cholera
Amino acid sequence of retinal transducin at the site ADP-ribosylated by cholera toxin.
Cholera
An antibody directed against residues 100-119 within the alpha-helical domain of Galpha(s) defines a novel contact site for beta-adrenergic receptors.
Cholera
An in vitro model of thyroid neoplasia: permanently transfected FRTL-5 cells with thyroglobulin promoter-cholera toxin A1 subunit minigene.
Cholera
Analysis of the T-cell activation signaling pathway mediated by tyrosine kinases, protein kinase C, and Ras protein, which is modulated by intracellular cyclic AMP.
Cholera
Antisense oligodeoxynucleotides to GS protein alpha-subunit sequence accelerate differentiation of fibroblasts to adipocytes.
Cholera
Association of a solubilized prostaglandin E2 receptor from renal medulla with a pertussis toxin-reactive guanine nucleotide regulatory protein.
Cholera
Basolateral to apical transcytosis in polarized cells is indirect and involves BFA and trimeric G protein sensitive passage through the apical endosome.
Cholera
Biochemical characterization of three stimulatory GTP-binding proteins. The large and small forms of Gs and the olfactory-specific G-protein, Golf.
Cholera
Biphasic regulation of adenylate cyclase by cholera toxin in neuroblastoma x glioma hybrid cells is due to the activation and subsequent loss of the alpha subunit of the stimulatory GTP binding protein (GS).
Cholera
Changes in cAMP formation in mononuclear leukocytes of heart and renal transplant recipients.
Cholera
Characterization of high affinity GTPase activity correlated to beta-adrenergic receptor stimulation of adenylyl cyclase in rat parotid membranes.
Cholera
Characterization of the membrane-associated GTPase activity: effects of chemotactic factors and toxins.
Cholera
Characterization of the plasma membrane bound GTPase from rabbit neutrophils. I. Evidence for an Ni-like protein coupled to the formyl peptide, C5a, and leukotriene B4 chemotaxis receptors.
Cholera
Characterization of transducin from bovine retinal rod outer segments. Mechanism and effects of cholera toxin-catalyzed ADP-ribosylation.
Cholera
Cholera toxin action on rabbit corpus luteum membranes: effects on adenylyl cyclase activity and adenosine diphospho-ribosylation of the stimulatory guanine nucleotide-binding regulatory component.
Cholera
Cholera toxin ADP-ribosylates the islet-activating protein substrate in adipocyte membranes and alters its function.
Cholera
Cholera toxin does not impair hormonal inhibition of adenylate cyclase and concomitant stimulation of a GTPase in adipocyte membranes.
Cholera
Cholera toxin impairment of opioid-mediated inhibition of adenylate cyclase in neuroblastoma x glioma hybrid cells is due to a toxin-induced decrease in opioid receptor levels.
Cholera
Cholera toxin induces cyclic AMP-independent down-regulation of Gs alpha and sensitization of alpha 2-autoreceptors in chick sympathetic neurons.
Cholera
Cholera toxin mediated regulation of the expression of Gq alpha and G11 alpha GTP binding proteins.
Cholera
Cholera toxin treatment produces down-regulation of the alpha-subunit of the stimulatory guanine-nucleotide-binding protein (Gs).
Cholera
Cholera toxin-induced Gs alpha down-regulation in neural tissue: studies on the pineal gland.
Cholera
Chronic activation of inhibitory delta-opioid receptors cross-regulates the stimulatory adenylate cyclase-coupled prostaglandin E1 receptor system in neuroblastoma x glioma (NG108-15) hybrid cells.
Cholera
Chronic ethanol treatment increases expression of inhibitory G-proteins and reduces adenylylcyclase activity in the central nervous system of two lines of ethanol-sensitive mice.
Cholera
Chronic exposure of rat glioma C6 cells to cholera toxin induces loss of the alpha-subunit of the stimulatory guanine nucleotide-binding protein (Gs).
Cholera
Chronic sympathectomy of canine cardiac ventricles affects Gs-adenylyl cyclase coupling and muscarinic receptor density.
Cholera
Cloning and characterization of a cDNA coding for the alpha-subunit of a stimulatory G protein from Schistosoma mansoni.
Cholera
Cloning and characterization of a G protein alpha-subunit-encoding gene from the basidiomycete, Coprinus congregatus.
Cholera
Cyclic AMP regulation of Gs protein. Thyrotropin and forskolin increase the quantity of stimulatory guanine nucleotide-binding proteins in cultured thyroid follicles.
Cholera
Decreased beta-adrenoceptor-mediated vasodilation in aorta from aged rats: possible involvement of a stimulatory GTP-binding protein.
Cholera
Decreased incorporation of the photoaffinity probe 8N3-[gamma-32P]-GTP into a 45kD protein in lung tumors.
Cholera
Deletion within the amino-terminal region of Gs alpha impairs its ability to interact with beta gamma subunits and to activate adenylate cyclase.
Cholera
Determination of the turn-off reaction for the epinephrine-inhibited human platelet adenylate cyclase.
Cholera
Developmental differences in the expression of the cholera toxin sensitive subunit (Gs alpha) of adenylate cyclase in the rat small intestine.
Cholera
Developmental regulation of calmodulin-dependent adenylate cyclase activity in an insect endocrine gland.
Cholera
Different domains in the third intracellular loop of the GLP-1 receptor are responsible for Galpha(s) and Galpha(i)/Galpha(o) activation.
Cholera
Differential expression of guanosine triphosphate binding proteins in men at high and low risk for the future development of alcoholism.
Cholera
Down-regulation of beta-adrenergic receptors by pindolol in Gs alpha-transfected S49 cyc- murine lymphoma cells.
Cholera
Down-regulation of protein kinase C by parathyroid hormone and mezerein differentially modulates cAMP production and phosphate transport in opossum kidney cells.
Cholera
Dynamin at the neck of caveolae mediates their budding to form transport vesicles by GTP-driven fission from the plasma membrane of endothelium.
Cholera
Effects of cholera toxin on the coupling of thyrotropin-releasing hormone to a guanine nucleotide-binding protein in cultured GH3 cells.
Cholera
Effects of phospholipid and GTP on recombinant ADP-ribosylation factors (ARFs). Molecular basis for differences in requirements for activity of mammalian ARFs.
Cholera
Endogenous ADP-ribosylation in brain: initial characterization of substrate proteins.
Cholera
Enhanced cyclic AMP responses in GH3 pituitary cells pretreated with muscarinic receptor agonists.
Cholera
Enhanced degradation of stimulatory G-protein (Gs alpha) by cholera toxin is mediated by ADP-ribosylation of Gs alpha protein but not by increased cyclic AMP levels.
Cholera
Enhanced expression of Gi proteins in non-hypertrophic hearts from rats with hypertension-induced by L-NAME treatment.
Cholera
Enhanced expression of GTP-binding proteins in differentiated U937 monocytic cells: possible involvement of tyrosine kinase and protein kinase C.
Cholera
Entamoeba invadens contains the components of a classical adrenergic signaling system.
Cholera
Essential role of GTP in the expression of adenylate cyclase activity after cholera toxin treatment.
Cholera
Estradiol up-regulates the stimulatory GTP-binding protein expression in the MCF-7 human mammary carcinoma cell line.
Cholera
Evidence for a defect in growth hormone-releasing factor signal transduction in the dwarf (dw/dw) rat pituitary.
Cholera
Evidence that activation of a common G-protein by receptors for leukotriene B4 and N-formylmethionyl-leucyl-phenylalanine in HL-60 cells occurs by different mechanisms.
Cholera
Expression and characterization of the long and short splice variants of GS alpha in S49 cyc- cells.
Cholera
Expression of cDNAs for G proteins in Escherichia coli. Two forms of Gs alpha stimulate adenylate cyclase.
Cholera
Expression of Plasmodium falciparum trimeric G proteins and their involvement in switching to sexual development.
Cholera
Forskolin potentiation of cholera toxin-stimulated cyclic AMP accumulation in intact C6-2B cells. Evidence for enhanced Gs-C coupling.
Cholera
Functional alteration of guanine nucleotide binding proteins (Gs and Gi) in psoriatic epidermis.
Cholera
Functional homology between signal-coupling proteins. Cholera toxin inactivates the GTPase activity of transducin.
Cholera
Functional modification by cholera-toxin-catalyzed ADP-ribosylation of a guanine-nucleotide-binding regulatory protein serving as the substrate of pertussis toxin.
Cholera
Functional modifications of transducin induced by cholera or pertussis-toxin-catalyzed ADP-ribosylation.
Cholera
G proteins in Aplysia: biochemical characterization and regional and subcellular distribution.
Cholera
G-proteins in guinea pig airway smooth muscle: identification and functional involvement.
Cholera
Gs alpha availability to cholera toxin-catalysed ADP-ribosylation is decreased in membranes of retinoic acid-treated leukemic cell lines HL-60 and THP-1. A posttranslational effect.
Cholera
Gs alpha is a substrate for mono(ADP-ribosyl)transferase of NG108-15 cells. ADP-ribosylation regulates Gs alpha activity and abundance.
Cholera
Gs alpha stimulates transcytosis and apical secretion in MDCK cells through cAMP and protein kinase A.
Cholera
Gs alpha-dependent and -independent desensitisation of prostanoid IP receptor-activated adenylyl cyclase in NG108-15 cells.
Cholera
GTP-binding proteins in luminal and basolateral membranes from pars convoluta and pars recta of rabbit kidney proximal tubule.
Cholera
Guanine nucleotide dependent formation of a complex between choleragen (cholera toxin) a subunit and bovine brain ADP-ribosylation factor.
Cholera
Guanine-nucleotide-binding proteins Gi and Gs in fat-cells from normal, hypothyroid and obese human subjects.
Cholera
Hamster alpha 1B-adrenergic receptor directly activates Gs in the transfected Chinese hamster ovary cells.
Cholera
Identification of a second putative receptor of platelet-activating factor from human polymorphonuclear leukocytes.
Cholera
Identification of G-proteins in rat parotid gland plasma membranes and granule membranes: presence of distinct components in granule membranes.
Cholera
Identification of guanine nucleotide binding regulatory proteins in bovine tracheal smooth muscle.
Cholera
Iloprost-induced translocation of a 23-kDa protein that is recognized by a Gs alpha antiserum.
Cholera
Immunochemical detection of GTP-binding protein in cephalopod photoreceptors by anti-peptide antibodies.
Cholera
Impaired growth hormone-releasing hormone signal transduction in the dwarf (dw) rat is independent of a generalized defect in the stimulatory G-protein, Gs alpha.
Cholera
Improvement of cholera toxin-catalyzed ADP-ribosylation by endogenous ADP-ribosylation factor from bovine brain provides evidence for an unchanged amount of Gs alpha in failing human myocardium.
Cholera
Inducible RGS2 is a cross-talk regulator for parathyroid hormone signaling in rat osteoblast-like UMR106 cells.
Cholera
Inhibition of ADP-ribosyltransferase increases synthesis of Gs alpha in neuroblastoma x glioma hybrid cells and reverses iloprost-dependent heterologous loss of fluoride-sensitive adenylate cyclase.
Cholera
Involvement of a high-affinity GTPase in the inhibitory coupling of striatal muscarinic receptors to adenylate cyclase.
Cholera
Involvement of calyculin A inhibitable protein phosphatases in the cyclic AMP signal transduction pathway of mouse corticotroph tumour (AtT20) cells.
Cholera
Involvement of signal transducing GTP-binding proteins in renal artery alpha 1-adrenoceptor mediated smooth muscle contraction.
Cholera
Islet-activating protein impairs alpha 2-adrenoceptor-mediated inhibitory regulation of human platelet adenylate cyclase.
Cholera
Light activation of phospholipase A2 in rod outer segments of bovine retina and its modulation by GTP-binding proteins.
Cholera
Light-regulated biochemical events in invertebrate photoreceptors. 1. Light-activated guanosinetriphosphatase, guanine nucleotide binding, and cholera toxin catalyzed labeling of squid photoreceptor membranes.
Cholera
Luteinizing hormone/choriogonadotropin-dependent, cholera toxin-catalyzed adenosine 5'-diphosphate (ADP)-ribosylation of the long and short forms of Gs alpha and pertussis toxin-catalyzed ADP-ribosylation of Gi alpha*.
Cholera
Mechanism of cholera toxin activation by a guanine nucleotide-dependent 19 kDa protein.
Cholera
Modification of the amounts of G proteins and of the activity of adenylyl cyclase in human benign thyroid tumours.
Cholera
Multiple coupling of human D5 dopamine receptors to guanine nucleotide binding proteins Gs and Gz.
Cholera
Multiple signalling pathways mediate fungal elicitor-induced beta-thujaplicin biosynthesis in Cupressus lusitanica cell cultures.
Cholera
Muscarinic blockade of beta-adrenoceptor-stimulated adenylyl cyclase: the role of stimulatory and inhibitory guanine-nucleotide binding regulatory proteins (Gs and Gi).
Cholera
Mutagenesis of the amino-terminal glycine to alanine in Gs alpha subunit alters beta gamma-dependent properties and decreases adenylylcyclase activation.
Cholera
Mutations of GS alpha designed to alter the reactivity of the protein with bacterial toxins. Substitutions at ARG187 result in loss of GTPase activity.
Cholera
Neutrophil activation by inflammatory microcrystals of monosodium urate monohydrate utilizes pertussis toxin-insensitive and -sensitive pathways.
Cholera
Nod factors activate both heterotrimeric and monomeric G-proteins in Vigna unguiculata (L.) Walp.
Cholera
Opiate and dopamine stimulate different GTPase in striatum: evidence for distinct modulatory mechanisms of adenylate cyclase.
Cholera
Opposite coupling of prostaglandin E receptor EP3C with Gs and G(o). Stimulation of Gs and inhibition of G(o).
Cholera
Pharmacological and biochemical characterization of dopamine receptors mediating stimulation of a high affinity GTPase in rat striatum.
Cholera
Plasma hyperosmolality increases G protein and 3',5'-cyclic adenosine monophosphate synthesis in the paraventricular and supraoptic nuclei.
Cholera
Platelet activating factor and U44069 stimulate a GTPase activity in human platelets which is distinct from the guanine nucleotide regulatory proteins, Ns and Ni.
Cholera
Platelet activating factor stimulates a receptor-coupled membrane GTPase in guinea pig eosinophils.
Cholera
Possible role of both the alpha and beta gamma subunits of the heterotrimeric G protein, Gs, in transcytosis of the polymeric immunoglobulin receptor.
Cholera
Priming effects of granulocyte-macrophage colony-stimulating factor are coupled to cholera toxin-sensitive guanine nucleotide binding protein in human T lymphocytes.
Cholera
Properties of a novel GTP-binding protein which is associated with soluble phosphoinositides-specific phospholipase C.
Cholera
Prostaglandin-stimulated GTP hydrolysis associated with activation of adenylate cyclase in human platelet membranes.
Cholera
Reduction of adenylyl cyclase activity by cholera toxin in myeloid cells. Long-term down-regulation of Gs alpha subunits by cholera toxin treatment.
Cholera
Regulation of G-proteins in differentiation. Altered ratio of alpha- to beta-subunits in 3T3-L1 cells.
Cholera
Regulation of transforming growth factor beta 1 action by multiple transducing pathways: evidence for both G protein-dependent and -independent signaling.
Cholera
Release of Gs alpha from rabbit intestinal cells following ADP-ribosylation by cholera toxin.
Cholera
Requirement of phosphatidylinositol 3-kinase activity for bradykinin stimulation of NF-kappaB activation in cultured human epithelial cells.
Cholera
Role of G protein beta gamma subunits in the regulation of the plasma membrane Ca2+ pump.
Cholera
Role of guanine nucleotide regulatory proteins and inositol phosphates in the hormone induced mobilization of hepatocyte calcium.
Cholera
Role of guanine nucleotides in the stimulation of thyroid adenylate cyclase by prostaglandin E1 and cholera toxin.
Cholera
Segregation of discrete GS alpha-mediated responses that accompany homologous or heterologous desensitization in two related somatic hybrids.
Cholera
Selective interactions of mu-opioid receptors with pertussis toxin-sensitive G proteins: involvement of the third intracellular loop and the c-terminal tail in coupling.
Cholera
Sensitization enhances the adenylyl cyclase responsiveness in alveolar macrophages. Changes induced at post-receptor level.
Cholera
Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs.
Cholera
Slow oscillations of free intracellular calcium ion concentration in human fibroblasts responding to mechanical stretch.
Cholera
Solubilization of the vasopressin receptor from rat liver plasma membranes. Evidence for a receptor X GTP-binding protein complex.
Cholera
Stimulation of high-affinity GTPase activity and cholera toxin-catalysed [32P]ADP-ribosylation of Gi by lysophosphatidic acid (LPA) in wild-type and alpha 2C10 adrenoceptor-transfected Rat 1 fibroblasts.
Cholera
Stimulation of rat parietal cell function by histamine and GLP-1-(7-36) amide is mediated by Gs alpha.
Cholera
Stimulatory and inhibitory guanine-nucleotide-binding regulatory protein involvement in stimulation of arachidonic-acid release by N-formyl-methionyl-leucyl-phenylalanine and platelet-activating factor from guinea-pig alveolar macrophages. Differential receptor/G-protein interaction assessed by pertussis and cholera toxins.
Cholera
Study of the phorbol ester effect on Alzheimer amyloid precursor processing: sequence requirements and involvement of a cholera toxin sensitive protein.
Cholera
The bioactive phospholipid, lysophosphatidylcholine, induces cellular effects via G-protein-dependent activation of adenylyl cyclase.
Cholera
The effect of cholera toxin on the inhibition of vasopressin-stimulated inositol phospholipid hydrolysis is a cyclic AMP-mediated event at the level of receptor binding.
Cholera
The glutamate-receptor linked cGMP cascade of retinal on-bipolar cells is pertussis and cholera toxin-sensitive.
Cholera
The inhibition of adenylyl cyclase activity in isolated lung membranes by muscarinic and alpha-adrenoceptor agonists: role of G-protein alpha and beta gamma sub-units.
Cholera
The presence of a heterotrimeric G protein and its role in signal transduction of extracellular calmodulin in pollen germination and tube growth
Cholera
Thrombin stimulates pertussis toxin-sensitive and -insensitive GTPase activities and ADP-ribosylation of G(i) in human neuroblastoma SH-EP.
Cholera
Thrombin, unlike vasopressin, appears to stimulate two distinct guanine nucleotide regulatory proteins in human platelets.
Cholera
Tissue and species distribution of mRNA encoding two ADP-ribosylation factors, 20-kDa guanine nucleotide binding proteins.
Cholera
Tissue inhibitor of metalloproteinase-2 stimulates fibroblast proliferation via a cAMP-dependent mechanism.
Cholera
Transient and steady state kinetics of the interaction of guanyl nucleotides with the adenylyl cyclase system from rat liver plasma membranes. Interpretation in terms of a simple two-state model.
Cholera
Translocation of alpha subunits of stimulatory guanine nucleotide-binding proteins through stimulation of the prostacyclin receptor in mouse mastocytoma cells.
Cholera
Vesicular transport is not required for the cytoplasmic pool of cholera toxin to interact with the stimulatory alpha subunit of the heterotrimeric g protein.
Cholera
Widespread distribution of Gq alpha/G11 alpha detected immunologically by an antipeptide antiserum directed against the predicted C-terminal decapeptide.
Cholera
[Effects of G-Protein Regulators and Stylar S-RNase on the Growth and Ca(2+) Concentration of Pyrus pyrifolia Pollen Tube.]
Cholera
[Inhibition of transducin by lithium: electrophysiological demonstration using the isolated retina]
Cholera
[The effect of G protein regulator on pollen germination and [Ca2+]i variation in Pyrus serotina Rehd. pollen.]
Choroidal Neovascularization
Activation of Rap1 inhibits NADPH oxidase-dependent ROS generation in retinal pigment epithelium and reduces choroidal neovascularization.
Choroidal Neovascularization
Rap1 GTPase Activation and Barrier Enhancement in RPE Inhibits Choroidal Neovascularization In Vivo.
Choroideremia
Mouse genetic corneal disease resulting from transgenic insertional mutagenesis.
Chronic Periodontitis
Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years.
Ciliary Motility Disorders
Novel Mutation in Retinitis Pigmentosa GTPase Regulator Gene Causes Primary Ciliary Dyskinesia and Retinitis Pigmentosa.
Ciliopathies
A common allele in RPGRIP1L is a modifier of retinal degeneration in ciliopathies.
Ciliopathies
A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation.
Ciliopathies
GTP-binding of ARL-3 is activated by ARL-13 as a GEF and stabilized by UNC-119.
Ciliopathies
Identification of a novel ARL13B variant in a Joubert syndrome-affected patient with retinal impairment and obesity.
Ciliopathies
Retinitis Pigmentosa GTPase Regulator (RPGR) protein isoforms in mammalian retina: insights into X-linked Retinitis Pigmentosa and associated ciliopathies.
Ciliopathies
RPGR isoform imbalance causes ciliary defects due to exon ORF15 mutations in X-linked retinitis pigmentosa (XLRP).
Ciliopathies
The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base.
Classical Swine Fever
Guanylate-binding protein 1, an interferon-induced GTPase, exerts an antiviral activity against classical swine fever virus depending on its GTPase activity.
Classical Swine Fever
Rab1A is required for assembly of classical swine fever virus particle.
Cleft Lip
Identification of a novel heterozygous truncation mutation in exon 1 of ARHGAP29 in an Indian subject with nonsyndromic cleft lip with cleft palate.
Cleft Palate
Identification of a novel heterozygous truncation mutation in exon 1 of ARHGAP29 in an Indian subject with nonsyndromic cleft lip with cleft palate.
Clonorchiasis
[Protective immunity of Cs-Rho GtPase recombinant protein against Clonorchis sinensis infection]
Cluster Headache
A study of adaptive responses in cell signaling in migraine and cluster headache: correlations between headache type and changes in gene expression.
Coinfection
A combinatorial G protein-coupled receptor reconstitution system on budded baculovirus. Evidence for Galpha and Galphao coupling to a human leukotriene B4 receptor.
Colitis
Central role of gimap5 in maintaining peripheral tolerance and T cell homeostasis in the gut.
Colitis
Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer.
Colitis
Long-term treatment with anti-alpha 4 integrin antibodies aggravates colitis in G alpha i2-deficient mice.
Colitis
Regression of Peyer's patches in G alpha i2 deficient mice prior to colitis is associated with reduced expression of Bcl-2 and increased apoptosis.
Colitis
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Colitis
Therapeutic targeting of alpha 4-integrins in chronic inflammatory diseases: tipping the scales of risk towards benefit?
Colitis, Ulcerative
Long-term treatment with anti-alpha 4 integrin antibodies aggravates colitis in G alpha i2-deficient mice.
Colitis, Ulcerative
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Colitis, Ulcerative
PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.
Colitis, Ulcerative
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Colitis, Ulcerative
Single Nucleotide Polymorphisms That Increase Expression of the Guanosine Triphosphatase RAC1 Are Associated With Ulcerative Colitis.
Colonic Neoplasms
A hallmark of immunoreceptor, the tyrosine-based inhibitory motif ITIM, is present in the G protein-coupled receptor OX1R for orexins and drives apoptosis: a novel mechanism.
Colonic Neoplasms
Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis.
Colonic Neoplasms
Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells.
Colonic Neoplasms
Quantitative Proteomics Analysis of Berberine-Treated Colon Cancer Cells Reveals Potential Therapy Targets.
Colonic Neoplasms
Rag GTPases suppress PRL-3 degradation and predict poor clinical diagnosis of cancer patients with low PRL-3 mRNA expression.
Colonic Neoplasms
Subcellular localization of the Galphai3 protein and G alpha interacting protein, two proteins involved in the control of macroautophagy in human colon cancer HT-29 cells.
Colonic Neoplasms
The mitochondrial permeability transition regulates cytochrome c release for apoptosis during endoplasmic reticulum stress by remodeling the cristae junction.
Colonic Neoplasms
Valine-286 residue in the third intracellular loop of the cholecystokinin 2 receptor exerts a pivotal role in cholecystokinin 2 receptor mediated intracellular signal transduction in human colon cancer cells.
Colonic Neoplasms
[A ?-catenin/IQGAP1 regulatory feedback loop and its effects on the proliferation of colon cancer cells].
Color Vision Defects
A naturally occurring mouse model of achromatopsia: characterization of the mutation in cone transducin and subsequent retinal phenotype.
Color Vision Defects
Cone cGMP-gated channel mutations and clinical findings in patients with achromatopsia, macular degeneration, and other hereditary cone diseases.
Color Vision Defects
Identification of a zebrafish cone photoreceptor-specific promoter and genetic rescue of achromatopsia in the nof mutant.
Color Vision Defects
Mapping of a novel locus for achromatopsia (ACHM4) to 1p and identification of a germline mutation in the alpha subunit of cone transducin (GNAT2).
Colorectal Neoplasms
A novel mechanism underlying phytate-mediated biological action-phytate hydrolysates induce intracellular calcium signaling by a Galphaq protein-coupled receptor and phospholipase C-dependent mechanism in colorectal cancer cells.
Colorectal Neoplasms
Aberrant expression of Rab1A and its prognostic significance in human colorectal cancer.
Colorectal Neoplasms
Clinical value and potential association of Rab1A and FoxM1 aberrant expression in colorectal cancer.
Colorectal Neoplasms
CRMP5-associated GTPase (CRAG) Is a Candidate Driver Gene for Colorectal Cancer Carcinogenesis.
Colorectal Neoplasms
Differential expression of Rac1 identifies its target genes and its contribution to progression of colorectal cancer.
Colorectal Neoplasms
Effects of RAL signal transduction in KRAS- and BRAF-mutated cells and prognostic potential of the RAL signature in colorectal cancer.
Colorectal Neoplasms
ENO1 Acts as a Prognostic Biomarker Candidate and Promotes Tumor Growth and Migration Ability Through the Regulation of Rab1A in Colorectal Cancer.
Colorectal Neoplasms
Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer.
Colorectal Neoplasms
Expression analysis and implication of Rab1A in gastrointestinal relevant tumor.
Colorectal Neoplasms
Inhibition of RAB1A suppresses epithelial-mesenchymal transition and proliferation of triple-negative breast cancer cells.
Colorectal Neoplasms
MicroRNA-31 Activates the RAS Pathway and Functions as an Oncogenic MicroRNA in Human Colorectal Cancer by Repressing RAS p21 GTPase Activating Protein 1 (RASA1).
Colorectal Neoplasms
Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Colorectal Neoplasms
Quantitative biophysical analysis defines key components modulating recruitment of the GTPase KRAS to the plasma membrane.
Colorectal Neoplasms
Rab1A promotes cell proliferation and migration by upregulating Gli1 in colorectal cancer.
Colorectal Neoplasms
Rab1A promotes proliferation and migration abilities via regulation of the HER2/AKT-independent mTOR/S6K1 pathway in colorectal cancer.
Colorectal Neoplasms
RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer.
Colorectal Neoplasms
The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism.
Colorectal Neoplasms
Wild?type blocking pcr coupled with internal competitive amplified fragment improved the detection of rare mutation of KRAS.
Cone Dystrophy
Cone dystrophy phenotype associated with a frameshift mutation (M280fsX291) in the alpha-subunit of cone specific transducin (GNAT2).
Cone Dystrophy
Exon screening of the genes encoding the beta- and gamma-subunits of cone transducin in patients with inherited retinal disease.
Cone-Rod Dystrophies
Cone cGMP-gated channel mutations and clinical findings in patients with achromatopsia, macular degeneration, and other hereditary cone diseases.
Cone-Rod Dystrophies
Exon screening of the genes encoding the beta- and gamma-subunits of cone transducin in patients with inherited retinal disease.
Cone-Rod Dystrophies
Phenotypic variation and genotype-phenotype discordance in canine cone-rod dystrophy with an RPGRIP1 mutation.
Cone-Rod Dystrophies
Successful gene therapy in the RPGRIP1-deficient dog, a large model of cone-rod dystrophy.
Congenital Abnormalities
The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis.
Congenital Disorders of Glycosylation
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
COVID-19
ACE2 Expression is Increased in the Lungs of Patients with Comorbidities Associated with Severe COVID-19.
Crohn Disease
Abnormal Activation of Autophagy-Induced Crinophagy in Paneth Cells From Patients With Crohn's Disease.
Crohn Disease
Among autophagy genes, ATG16L1 but not IRGM is associated with Crohn's disease in Iranians.
Crohn Disease
Correlation between IRGM genetic polymorphisms and Crohn's disease risk: a meta-analysis of case-control studies.
Crohn Disease
Crohn's disease IRGM risk alleles are associated with altered gene expression in human tissues.
Crohn Disease
CUBAP: an interactive web portal for analyzing codon usage biases across populations.
Crohn Disease
Genetic Polymorphisms in Autophagy-Associated Genes in Korean Children With Early-Onset Crohn Disease.
Crohn Disease
Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease.
Crohn Disease
IRGM rs13361189 polymorphism may contribute to susceptibility to Crohn's disease: A meta-analysis.
Crohn Disease
Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling.
Crohn Disease
Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation.
Crohn Disease
Is there a role for Crohn's disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas?
Crohn Disease
mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1.
Crohn Disease
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Crohn Disease
PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.
Crohn Disease
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Cushing Syndrome
Activating mutation in the stimulatory guanine nucleotide-binding protein in an infant with Cushing's syndrome and nodular adrenal hyperplasia.
Cushing Syndrome
Presence of a Gs alpha mutation in an adrenal tumor expressing LH/hCG receptors and clinically associated with Cushing's syndrome.
Cutis Laxa
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Cystic Fibrosis
A recombinant polypeptide model of the second nucleotide-binding fold of the cystic fibrosis transmembrane conductance regulator functions as an active ATPase, GTPase and adenylate kinase.
Cystic Fibrosis
G protein G alpha i-2 inhibits outwardly rectifying chloride channels in human airway epithelial cells.
Cystic Fibrosis
Inhibition of ATPase, GTPase and adenylate kinase activities of the second nucleotide-binding fold of the cystic fibrosis transmembrane conductance regulator by genistein.
Cysts
Definitive evidence using enucleated cytoplasts for a nongenomic basis for the cystic change in endoplasmic reticulum structure caused by STAT5a/b siRNAs.
Cysts
Non-genomic STAT5-dependent effects at the endoplasmic reticulum and Golgi apparatus and STAT6-GFP in mitochondria.
Cysts
Rab35 GTPase couples cell division with initiation of epithelial apico-basal polarity and lumen opening.
Cysts
Rac Regulates Giardia lamblia Encystation by Coordinating Cyst Wall Protein Trafficking and Secretion.
Cysts
Ric-8A, an activator protein of G?i, controls mammalian epithelial cell polarity for tight junction assembly and cystogenesis.
Cysts
Tuba, a Cdc42 GEF, is required for polarized spindle orientation during epithelial cyst formation.
Deafness
A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness.
Deafness
Ebi/AP-1 suppresses pro-apoptotic genes expression and permits long-term survival of Drosophila sensory neurons.
Deafness
Molecular analysis of TBL1Y, a Y-linked homologue of TBL1X related with X-linked late-onset sensorineural deafness.
Deafness
Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form.
Dementia
On the stability of messenger RNA and ribosomal RNA in the brains of control human subjects and patients with Alzheimer's disease.
Demyelinating Diseases
Mdivi-1, a mitochondrial fission inhibitor, modulates T helper cells and suppresses the development of experimental autoimmune encephalomyelitis.
Dermatitis, Atopic
Upregulation of the transcript level of GTPase activating protein KIAA0603 in T cells from patients with atopic dermatitis.
Diabetes Mellitus
Expression of the heterotrimeric G protein Gi and ATP release are impaired in erythrocytes of humans with diabetes mellitus.
Diabetes Mellitus
Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level.
Diabetes Mellitus
Rac1 Modulates Endothelial Function and Platelet Aggregation in Diabetes Mellitus.
Diabetes Mellitus, Type 1
GIMAP GTPase family genes: potential modifiers in autoimmune diabetes, asthma, and allergy.
Diabetes Mellitus, Type 2
Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis.
Diabetes Mellitus, Type 2
Muscle Rad expression and human metabolism: potential role of the novel Ras-related GTPase in energy expenditure and body composition.
Diabetes Mellitus, Type 2
Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level.
Diabetes Mellitus, Type 2
Tissue-specific alterations in G protein expression in genetic versus diet-induced models of non-insulin-dependent diabetes mellitus in the mouse.
Diabetic Nephropathies
RhoA/Rho-kinase contribute to the pathogenesis of diabetic renal disease.
Diabetic Retinopathy
The Regulatory Role of Rac1, a Small Molecular Weight GTPase, in the Development of Diabetic Retinopathy.
Diphtheria
A recombinant fusion toxin targeted to the granulocyte-macrophage colony-stimulating factor receptor.
Diphtheria
A screening procedure for the intracellular expression of native proteins by Saccharomyces cerevisiae: discrimination of diphtheria toxin-resistant mutants.
Diphtheria
Active-site mutations of the diphtheria toxin catalytic domain: role of histidine-21 in nicotinamide adenine dinucleotide binding and ADP-ribosylation of elongation factor 2.
Diphtheria
ADP-ribosylated elongation factor 2 (ADP-ribosyl-EF-2) is unable to promote translocation within the ribosome.
Diphtheria
ADP-ribosylation of elongation factor 2 by diphtheria toxin. Isolation and properties of the novel ribosyl-amino acid and its hydrolysis products.
Diphtheria
ADP-ribosylation of elongation factor 2 by diphtheria toxin. NMR spectra and proposed structures of ribosyl-diphthamide and its hydrolysis products.
Diphtheria
Autoradiographic assay of mutants resistant to diphtheria toxin in mammalian cells in vitro.
Diphtheria
Biosynthesis of diphthamide in Saccharomyces cerevisiae. Partial purification and characterization of a specific S-adenosylmethionine:elongation factor 2 methyltransferase.
Diphtheria
Characteristics of guinea-pig immune sera elicited by a synthetic diphtheria toxin oligopeptide.
Diphtheria
Characterization of a transgenic mouse line lacking photoreceptor development within the ventral retina.
Diphtheria
Characterization of Ca2+/calmodulin-dependent protein kinase in rat pancreatic islets.
Diphtheria
Complete nucleotide sequence and characterization of the 5'-flanking region of mammalian elongation factor 2 gene.
Diphtheria
Differential toxicity of ricin and diphtheria toxin for bloodstream forms of Trypanosoma brucei.
Diphtheria
Diphtheria toxin and its ADP-ribosyltransferase-defective homologue CRM197 possess deoxyribonuclease activity.
Diphtheria
Diphtheria toxin as a molecular tool in the study of acidic fibroblast growth factor signalling.
Diphtheria
Diphtheria toxin does not enter resistant cells by receptor-mediated endocytosis.
Diphtheria
Diphtheria toxin NAD affinity and ADP ribosyltransferase activity are reduced at tryptophan 153 substitutions for alanine or phenylalanine.
Diphtheria
Diphtheria toxin prevents catecholamine desensitization of A431 human epidermoid carcinoma cells.
Diphtheria
Diphtheria toxin-related cytokine fusion proteins: elongation factor 2 as a target for the treatment of neoplastic disease.
Diphtheria
Diphtheria toxin. Site and configuration of ADP-ribosylation of diphthamide in elongation factor 2.
Diphtheria
Endogenous ADP-ribosylation for eukaryotic elongation factor 2: evidence of two different sites and reactions.
Diphtheria
Enzymatically active peptide from the adenosine diphosphate-ribosylating toxin of Pseudomonas aeruginosa.
Diphtheria
Eukaryotic elongation factor 2 loses its non-specific affinity for RNA and leaves polyribosomes as a result of ADP-ribosylation.
Diphtheria
Eukaryotic elongation factor-2 (eEF-2) activity in bovine mammary tissue in relation to milk protein synthesis.
Diphtheria
Evidence of endogenous mono-ADP-ribosylation of cardiac proteins via anti-ADP-ribosylarginine immunoreactivity.
Diphtheria
Expression of functional diphtheria toxin receptors on highly toxin-sensitive mouse cells that specifically bind radioiodinated toxin.
Diphtheria
Expression of non-ADP-ribosylatable, diphtheria toxin-resistant elongation factor 2 in Saccharomyces cerevisiae.
Diphtheria
Gene for the diphtheria toxin-susceptible elongation factor 2 from Methanococcus vannielii.
Diphtheria
Genetic analysis of the cell surface: association of human chromosome 5 with sensitivity to diphtheria toxin in mouse-human somatic cell hybrids.
Diphtheria
In vitro biosynthesis of diphthamide, studied with mutant Chinese hamster ovary cells resistant to diphtheria toxin.
Diphtheria
In vitro-translated diphtheria toxin A chain inhibits translation in wheat germ extracts: analysis of biologically active, caspase-3-resistant diphtheria toxin mutants.
Diphtheria
Interaction of diphtheria toxin fragment A and of elongation factor 2 with cibacron blue.
Diphtheria
Interleukin 2 receptor-targeted cytotoxicity. Interleukin 2 receptor-mediated action of a diphtheria toxin-related interleukin 2 fusion protein.
Diphtheria
Introduction of additional charges as an aid in protein purification: isolation of elongation factor 2 from Sulfolobus acidocaldarius by preparative isoelectric focusing before and after ADP-ribosylation.
Diphtheria
Isolation and distribution of elongation factor 2 in eggs and embryos of sea urchins.
Diphtheria
Isolation and properties of the trypsin-derived ADP-ribosyl peptide from diphtheria toxin-modified yeast elongation factor 2.
Diphtheria
Kinetics of adenosinediphosphoribosylation of elongation factor 2 in cells exposed to diphtheria toxin.
Diphtheria
Modulation of the intracellular stability and toxicity of diphtheria toxin through degradation by the N-end rule pathway.
Diphtheria
Molecular cloning and expression of gene fragments from corynebacteriophage beta encoding enzymatically active peptides of diphtheria toxin.
Diphtheria
Molecular, functional and structural properties of an archaebacterial elongation factor 2.
Diphtheria
Mutations in the elongation factor 2 gene which confer resistance to diphtheria toxin and Pseudomonas exotoxin A. Genetic and biochemical analyses.
Diphtheria
Posttranslational modification of elongation factor 2 in diphtheria-toxin-resistant mutants of CHO-K1 cells.
Diphtheria
Preparation and properties of chimeric toxins prepared from the constituent polypeptides of diphtheria toxin and ricin. Evidence for entry of ricin A-chain via the diphtheria toxin pathway.
Diphtheria
Primary structure at the site in beef and wheat elongation factor 2 of ADP-ribosylation by diphtheria toxin.
Diphtheria
Primary structure of elongation factor 2 around the site of ADP-ribosylation is highly conserved from archaebacteria to eukaryotes.
Diphtheria
Pseudomonas aeruginosa exoenzyme S: an adenosine diphosphate ribosyltransferase distinct from toxin A.
Diphtheria
Purification and properties of an altered form of elongation factor 2 from mutant cells resistant to intoxication by diphtheria toxin.
Diphtheria
Purification of a nitric oxide-stimulated ADP-ribosylated protein using biotinylated beta-nicotinamide adenine dinucleotide.
Diphtheria
Purification of elongation factor 2 from human placenta and evidence of its fragmentation patterns in various eukaryotic sources.
Diphtheria
Recognition of elongation factor 2 by diphtheria toxin is not solely defined by the presence of diphthamide.
Diphtheria
Reconstitution of active diphtheria toxin based on a hexahistidine tagged version of the B-fragment produced to high yields in bacteria.
Diphtheria
Requirement for prolonged action in the cytosol for optimal protein synthesis inhibition by diphtheria toxin.
Diphtheria
Ribosyl-diphthamide: confirmation of structure by fast atom bombardment mass spectrometry.
Diphtheria
Saccharomyces cerevisiae elongation factor 2. Mutagenesis of the histidine precursor of diphthamide yields a functional protein that is resistant to diphtheria toxin.
Diphtheria
Targeted introduction of a diphtheria toxin resistant mutation into the chromosomal EF-2 locus of Pichia pastoris and expression of immunotoxin in the EF-2 mutants.
Diphtheria
The Father, Son and Cholix Toxin: The Third Member of the DT Group Mono-ADP-Ribosyltransferase Toxin Family.
Diphtheria
The frequency of mutants in human fibroblasts UV-irradiated at various times during S-phase suggests that genes for thioguanine- and diphtheria toxin-resistance are replicated early.
Diphtheria
The mechanism of ADP-ribosylation of elongation factor 2 catalyzed by fragment A from diphtheria toxin.
Diphtheria
Translocation of diphtheria toxin to the cytosol and formation of cation selective channels.
Diphtheria
Use of synthetic peptides and site-specific antibodies to localize a diphtheria toxin sequence associated with ADP-ribosyltransferase activity.
Distemper
Autophagy induction by the pathogen receptor NECTIN4 and sustained autophagy contribute to peste des petits ruminants virus infectivity.
Drug Resistant Epilepsy
Pathogenic DNM1 Gene Variant Presenting With Unusually Nonsevere Neurodevelopmental Phenotype: A Case Report.
Dwarfism
Brachytic 1 of barley (Hordeum vulgare L.) encodes the ? subunit of heterotrimeric G protein.
Dwarfism
Function and expression pattern of the alpha subunit of the heterotrimeric G protein in rice.
Dwarfism
Heterotrimeric G protein alpha subunit is involved in rice brassinosteroid response.
Dwarfism
Rice transgenic plants with suppressed expression of the ? subunit of the heterotrimeric G protein.
Dwarfism
Suppression of the heterotrimeric G protein causes abnormal morphology, including dwarfism, in rice.
Dysentery, Amebic
Heterotrimeric G-protein signaling is critical to pathogenic processes in Entamoeba histolytica.
Dyskinesias
D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways.
Dyskinesias
RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum.
Encephalitis
Flavonoids influence monocytic GTPase activity and are protective in experimental allergic encephalitis.
Encephalitis, Japanese
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Encephalomyelitis
Immune-related GTPase Irgm1 exacerbates experimental auto-immune encephalomyelitis by promoting the disruption of blood-brain barrier and blood-cerebrospinal fluid barrier.
Encephalomyelitis
Over-expression of GTP-binding proteins and GTPase activity in mouse astrocyte membranes in response to Theiler's murine encephalomyelitis virus infection.
Encephalomyelitis
Ulk1 Governs Nerve Growth Factor/TrkA Signaling by Mediating Rab5 GTPase Activation in Porcine Hemagglutinating Encephalomyelitis Virus-Induced Neurodegenerative Disorders.
Endometrial Neoplasms
NMU signaling promotes endometrial cancer cell progression by modulating adhesion signaling.
Endometriosis
Hepatocyte nuclear factor (HNF)-1? and its physiological importance in endometriosis.
Endotoxemia
The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia.
Epilepsies, Myoclonic
Generalized myoclonic epilepsy with photosensitivity in juvenile dogs caused by a defective DIRAS family GTPase 1.
Epilepsy
Altered Expression of the Small Guanosine Triphosphatase RhoA in Human Temporal Lobe Epilepsy.
Epilepsy, Temporal Lobe
Altered Expression of the Small Guanosine Triphosphatase RhoA in Human Temporal Lobe Epilepsy.
Esophageal Neoplasms
Aberrant methylation of the Ras-related associated with diabetes gene in human primary esophageal cancer.
Esophageal Neoplasms
Comprehensive multi-omics analysis identified core molecular processes in esophageal cancer and revealed GNGT2 as a potential prognostic marker.
Essential Hypertension
No evidence for involvement of alleles of the 825-C/T polymorphism of the G-protein subunit beta 3 in body weight regulation.
Essential Hypertension
Selectively enhanced cellular signaling by Gi proteins in essential hypertension. G alpha i2, G alpha i3, G beta 1, and G beta 2 are not mutated.
Exanthema
Relationship among guanine nucleotide exchange, GTP hydrolysis, and transforming potential of mutated ras proteins.
Eye Diseases
The interplay between RPGR, PDE? and Arl2/3 regulate the ciliary targeting of farnesylated cargo.
Fatty Liver
Hepatic Deficiency in Transcriptional Cofactor TBL1 Promotes Liver Steatosis and Hypertriglyceridemia.
Fatty Liver
Variants in the autophagy-related gene IRGM confer susceptibility to non-alcoholic fatty liver disease by modulating lipophagy.
Fibrosarcoma
Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.
Fibrous Dysplasia of Bone
An activating Gs alpha mutation is present in fibrous dysplasia of bone in the McCune-Albright syndrome.
Fibrous Dysplasia of Bone
Endocrine manifestations of stimulatory G protein alpha-subunit mutations and the role of genomic imprinting.
Fibrous Dysplasia of Bone
Juxta-articular myxoma and intramuscular myxoma are two distinct entities. Activating Gs alpha mutation at Arg 201 codon does not occur in juxta-articular myxoma.
Fibrous Dysplasia of Bone
The histopathology of fibrous dysplasia of bone in patients with activating mutations of the Gs alpha gene: site-specific patterns and recurrent histological hallmarks.
Fibrous Dysplasia, Monostotic
Increased proliferation of osteoblastic cells expressing the activating Gs alpha mutation in monostotic and polyostotic fibrous dysplasia.
Fibrous Dysplasia, Polyostotic
A Case of McCune-Albright Syndrome Associated with Gs alpha Mutation in the Bone Tissue.
Fibrous Dysplasia, Polyostotic
ACTH-independent massive bilateral adrenal disease (AIMBAD): a subtype of Cushing's syndrome with major diagnostic and therapeutic implications.
Fibrous Dysplasia, Polyostotic
Activating mutation in the stimulatory guanine nucleotide-binding protein in an infant with Cushing's syndrome and nodular adrenal hyperplasia.
Fibrous Dysplasia, Polyostotic
Activating mutation of GS alpha in McCune-Albright syndrome causes skin pigmentation by tyrosinase gene activation on affected melanocytes.
Fibrous Dysplasia, Polyostotic
Activating mutations of the stimulatory G protein in the McCune-Albright syndrome.
Fibrous Dysplasia, Polyostotic
An activating Gs alpha mutation is present in fibrous dysplasia of bone in the McCune-Albright syndrome.
Fibrous Dysplasia, Polyostotic
Endocrine manifestations of stimulatory G protein alpha-subunit mutations and the role of genomic imprinting.
Fibrous Dysplasia, Polyostotic
Fibrous dysplasia of bone in the McCune-Albright syndrome: abnormalities in bone formation.
Fibrous Dysplasia, Polyostotic
Growth hormone-prolactin-thyrotropin-secreting pituitary adenoma in atypical McCune-Albright syndrome with functionally normal Gs alpha protein.
Fibrous Dysplasia, Polyostotic
Gs alpha mutation at codon 201 in pituitary adenoma causing gigantism in a 6-year-old boy with McCune-Albright syndrome.
Fibrous Dysplasia, Polyostotic
Gs(alpha) mutations and imprinting defects in human disease.
Fibrous Dysplasia, Polyostotic
Identification of a second-site suppressor mutation of the GTPase defect associated with McCune-Albright syndrome: a model using the yeast heterotrimeric G protein, GPA1.
Fibrous Dysplasia, Polyostotic
Increased expression of the c-fos proto-oncogene in bone from patients with fibrous dysplasia.
Fibrous Dysplasia, Polyostotic
Increased proliferation of osteoblastic cells expressing the activating Gs alpha mutation in monostotic and polyostotic fibrous dysplasia.
Fibrous Dysplasia, Polyostotic
Juxta-articular myxoma and intramuscular myxoma are two distinct entities. Activating Gs alpha mutation at Arg 201 codon does not occur in juxta-articular myxoma.
Fibrous Dysplasia, Polyostotic
Odontogenic myxomas are not associated with activating mutations of the Gs alpha gene.
Fibrous Dysplasia, Polyostotic
Ovarian dysfunction by activating mutation of GS alpha: McCune-Albright syndrome as a model.
Fibrous Dysplasia, Polyostotic
Sporadic cardiac myxomas and tumors from patients with Carney complex are not associated with activating mutations of the Gs alpha gene.
Fibrous Dysplasia, Polyostotic
The histopathology of fibrous dysplasia of bone in patients with activating mutations of the Gs alpha gene: site-specific patterns and recurrent histological hallmarks.
Fibrous Dysplasia, Polyostotic
Thyroid carcinoma in the McCune-Albright syndrome: contributory role of activating Gs alpha mutations.
Fibrous Dysplasia, Polyostotic
Urinary cyclic adenosine 3',5'-monophosphate response in McCune-Albright syndrome: clinical evidence for altered renal adenylate cyclase activity.
Frontotemporal Lobar Degeneration
SMCR8 negatively regulates AKT and MTORC1 signaling to modulate lysosome biogenesis and tissue homeostasis.
Gallstones
A new heterozygous mutation (D196N) in the Gs alpha gene as a cause for pseudohypoparathyroidism type IA in a boy who had gallstones.
Gastrinoma
Gs alpha--identification of a gene highly expressed by insulinoma and other endocrine tumors.
Gastrointestinal Neoplasms
Expression analysis and implication of Rab1A in gastrointestinal relevant tumor.
Gastrointestinal Neoplasms
Molecular mutation characteristics of mismatch and homologous recombination repair genes in gastrointestinal cancer.
Genetic Diseases, Inborn
Genetic and functional studies implicate synaptic overgrowth and ring gland cAMP/PKA signaling defects in the Drosophila melanogaster neurofibromatosis-1 growth deficiency.
Genetic Diseases, Inborn
Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration-implications for increased neurofibroma formation during pregnancy.
Genetic Diseases, Inborn
Novel functional features of the Lis-H domain: role in protein dimerization, half-life and cellular localization.
Gigantism
Gs alpha mutation at codon 201 in pituitary adenoma causing gigantism in a 6-year-old boy with McCune-Albright syndrome.
Glaucoma
Research progress on human genes involved in the pathogenesis of glaucoma (Review).
Glaucoma, Open-Angle
Evidence for RPGRIP1 gene as risk factor for primary open angle glaucoma.
Glioblastoma
Aberrant splicing of Gs alpha transcript in transformed human astroglial and glioblastoma cell lines.
Glioblastoma
Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFR?-stimulated glioma tumorigenesis in mice and humans.
Glioblastoma
ADP-Ribosylation Factor Like GTPase 4C (ARL4C) augments stem-like traits of glioblastoma cells by upregulating ALDH1A3.
Glioblastoma
Analysis of microarray data for identification of key microRNA signatures in glioblastoma multiforme.
Glioblastoma
Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion.
Glioblastoma
Efficient proliferation and mitosis of glioblastoma cells infected with human cytomegalovirus is mediated by RhoA GTPase.
Glioblastoma
In vivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family GTPases in glioblastoma cell invasion.
Glioblastoma
Nuclear translocation of fibroblast growth factor-2 (FGF2) is regulated by Karyopherin-?2 and Ran GTPase in human glioblastoma cells.
Glioma
ADP-Ribosylation Factor Like GTPase 4C (ARL4C) augments stem-like traits of glioblastoma cells by upregulating ALDH1A3.
Glioma
Antibodies which recognize the C-terminus of the inhibitory guanine-nucleotide-binding protein (Gi) demonstrate that opioid peptides and foetal-calf serum stimulate the high-affinity GTPase activity of two separate pertussis-toxin substrates.
Glioma
Bradykinin stimulates GTP hydrolysis in NG108-15 membranes by a high-affinity, pertussis toxin-insensitive GTPase.
Glioma
Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells.
Glioma
Cholera toxin impairment of opioid-mediated inhibition of adenylate cyclase in neuroblastoma x glioma hybrid cells is due to a toxin-induced decrease in opioid receptor levels.
Glioma
Cholera toxin mediated regulation of the expression of Gq alpha and G11 alpha GTP binding proteins.
Glioma
Delta-opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein Gi2.
Glioma
Differential effects of suramin on the coupling of receptors to individual species of pertussis-toxin-sensitive guanine-nucleotide-binding proteins.
Glioma
Endogenous regulator of G protein signaling proteins suppress Galphao-dependent, mu-opioid agonist-mediated adenylyl cyclase supersensitization.
Glioma
Enhanced degradation of stimulatory G-protein (Gs alpha) by cholera toxin is mediated by ADP-ribosylation of Gs alpha protein but not by increased cyclic AMP levels.
Glioma
Equivalent regulation of wild type and an epitope-tagged variant of Gs alpha by the IP prostanoid receptor following expression in neuroblastoma x glioma hybrid, NG108-15, cells.
Glioma
Exosomes derived from microRNA-199a-overexpressing mesenchymal stem cells inhibit glioma progression by down-regulating AGAP2.
Glioma
Foetal-calf serum stimulates a pertussis-toxin-sensitive high-affinity GTPase activity in rat glioma C6 BU1 cells.
Glioma
Guanine nucleotide regulation of the pertussis and cholera toxin substrates of rat glioma C6 BU1 cells.
Glioma
Guanylate binding protein 1 is a novel effector of EGFR-driven invasion in glioblastoma.
Glioma
High expression of immunity-related GTPase family M protein in glioma promotes cell proliferation and autophagy protein expression.
Glioma
Identification of the critical domains of the delta-opioid receptor involved in G protein coupling using site-specific synthetic peptides.
Glioma
Inhibition of ADP-ribosyltransferase increases synthesis of Gs alpha in neuroblastoma x glioma hybrid cells and reverses iloprost-dependent heterologous loss of fluoride-sensitive adenylate cyclase.
Glioma
IRGM promotes glioma M2 macrophage polarization through p62/TRAF6/NF-?B pathway mediated IL-8 production.
Glioma
Irgm1 knockout indirectly inhibits regeneration after skeletal muscle injury in mice.
Glioma
Is current therapy of malignant gliomas beneficial for patients? Proteomics evidence of shifts in glioma cells expression patterns under clinically relevant treatment conditions.
Glioma
Knockdown of Rab21 inhibits proliferation and induces apoptosis in human glioma cells.
Glioma
LncRNA DANCR functions as a competing endogenous RNA to regulate RAB1A expression by sponging miR-634 in glioma.
Glioma
Modulation of sodium-sensitive GTPase by partial opiate agonists. An explanation for the dual requirement for Na+ and GTP in inhibitory regulation of adenylate cyclase.
Glioma
Persistent activation of the alpha subunit of Gs promotes its removal from the plasma membrane.
Glioma
Probing the infiltrating character of brain tumors: inhibition of RhoA/ROK-mediated CD44 cell surface shedding from glioma cells by the green tea catechin EGCg.
Glioma
Prostaglandin E1-mediated, cyclic AMP-independent, down-regulation of Gs alpha in neuroblastoma x glioma hybrid cells.
Glioma
Quantitative stoichiometry of the proteins of the stimulatory arm of the adenylyl cyclase cascade in neuroblastoma x glioma hybrid, NG108-15 cells.
Glioma
RAB1A regulates glioma cellular proliferation and invasion via the mTOR signaling pathway and epithelial-mesenchymal transition.
Glioma
Role of calmodulin-dependent phosphorylation of elongation factor 2 in the proliferation of rat glial cells.
Glioma
Secretion of protease nexin-1 by C6 glioma cells is under the control of a heterotrimeric G protein, Go1.
Glioma
SEPT7 overexpression inhibits glioma cell migration by targeting the actin cytoskeleton pathway.
Glioma
The small GTPase Rac1 is involved in the maintenance of stemness and malignancies in glioma stem-like cells.
Glioma
Tubulin stimulates adenylyl cyclase activity in rat striatal membranes via transfer of guanine nucleotide to Gs protein.
Glioma
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioblastoma cell chemotaxis via Lyn activation.
Glomerulonephritis, Membranous
Both Peripheral Blood and Urinary miR-195-5p, miR-192-3p, miR-328-5p and Their Target Genes PPM1A, RAB1A and BRSK1 May Be Potential Biomarkers for Membranous Nephropathy.
Glucose Intolerance
The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice.
glutamate-5-semialdehyde dehydrogenase deficiency
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Goiter
Activating thyrotropin receptor mutations are present in nonadenomatous hyperfunctioning nodules of toxic or autonomous multinodular goiter.
Goiter
Constitutive activation of the Gs alpha protein-adenylate cyclase pathway may not be sufficient to generate toxic thyroid adenomas.
Goiter
Identification of constitutively activating somatic thyrotropin receptor mutations in a subset of toxic multinodular goiters.
Goiter
The thyrotropin receptor (TSH-R) is not an oncogene for thyroid tumors: structural studies of the TSH-R and the alpha-subunit of Gs in human thyroid neoplasms.
Gonorrhea
The Neisseria gonorrhoeae Obg protein is an essential ribosome-associated GTPase and a potential drug target.
Graft vs Host Disease
Reciprocal function of Galphai2 and Galphai3 in graft-versus-host disease.
Granulomatous Disease, Chronic
The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion.
Granulosa Cell Tumor
Analysis of mutations in genes of the follicle-stimulating hormone receptor signaling pathway in ovarian granulosa cell tumors.
Growth Hormone-Secreting Pituitary Adenoma
Analysis of the Gs alpha gene in growth hormone-secreting pituitary adenomas by the polymerase chain reaction-direct sequencing method using paraffin-embedded tissues.
Growth Hormone-Secreting Pituitary Adenoma
Glycoprotein hormone alpha-subunit production in somatotroph adenomas with and without Gs alpha mutations.
Growth Hormone-Secreting Pituitary Adenoma
Gs alpha overexpression and loss of Gs alpha imprinting in human somatotroph adenomas: association with tumor size and response to pharmacologic treatment.
Growth Hormone-Secreting Pituitary Adenoma
Heterozygous gsp mutation renders ion channels of human somatotroph adenoma cells unresponsive to growth hormone-releasing hormone.
Growth Hormone-Secreting Pituitary Adenoma
Low prevalence of Gs alpha mutations in Åomatotroph adenomas of children and adolescents.
Growth Hormone-Secreting Pituitary Adenoma
Pronostic and therapeutic consequences of Gs alpha mutations in somatotroph adenomas.
Growth Hormone-Secreting Pituitary Adenoma
Rare mutations of the Gs alpha subunit gene in human endocrine tumors. Mutation detection by polymerase chain reaction-primer-introduced restriction analysis.
Growth Hormone-Secreting Pituitary Adenoma
[Pathophysiology and gene abnormalities of endocrine tumors]
Hearing Loss
Ebi/AP-1 suppresses pro-apoptotic genes expression and permits long-term survival of Drosophila sensory neurons.
Hearing Loss, Sensorineural
Congenital isolated central hypothyroidism: Novel mutations and their functional implications.
Heart Diseases
A functional polymorphism of the G{alpha}q (GNAQ) gene is associated with accelerated mortality in African-American heart failure.
Heart Failure
A functional polymorphism of the G{alpha}q (GNAQ) gene is associated with accelerated mortality in African-American heart failure.
Heart Failure
Activation of G?q in Cardiomyocytes Increases Vps34 Activity and Stimulates Autophagy.
Heart Failure
Akt-mediated cardiomyocyte survival pathways are compromised by G alpha q-induced phosphoinositide 4,5-bisphosphate depletion.
Heart Failure
Alterations in Ca2+ cycling proteins and G alpha q signaling after left ventricular assist device support in failing human hearts.
Heart Failure
Beta-adrenoceptor-G protein-adenylate cyclase complex in rat hearts with ischemic heart failure produced by coronary artery ligation.
Heart Failure
Decreased Gs alpha mRNA levels accompany the fall in Gs and adenylyl cyclase activities in compensated left ventricular hypertrophy. In heart failure, only the impairment in adenylyl cyclase activation progresses.
Heart Failure
Diacylglycerol kinase zeta rescues G alpha q-induced heart failure in transgenic mice.
Heart Failure
Diverse G protein and beta-adrenergic receptor mRNA expression in normal and failing porcine hearts.
Heart Failure
Enhanced exercise capacity in mice with severe heart failure treated with an allosteric effector of hemoglobin, myo-inositol trispyrophosphate.
Heart Failure
Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure.
Heart Failure
Expression of Gi-2 alpha and Gs alpha in myofibroblasts localized to the infarct scar in heart failure due to myocardial infarction.
Heart Failure
Improvement of cholera toxin-catalyzed ADP-ribosylation by endogenous ADP-ribosylation factor from bovine brain provides evidence for an unchanged amount of Gs alpha in failing human myocardium.
Heart Failure
Increased myocardial Rab GTPase expression: a consequence and cause of cardiomyopathy.
Heart Failure
Markedly increased Rho-kinase activity in circulating leukocytes in patients with chronic heart failure.
Heart Failure
Mechanisms of impaired beta-adrenergic receptor signaling in G(alphaq)-mediated cardiac hypertrophy and ventricular dysfunction.
Heart Failure
Potential Treatment of Cardiac Hypertrophy and Heart Failure by Inhibiting the Sarcolemmal Binding of Phospholipase Cbeta1b.
Heart Failure
Propranolol prevents enhanced stress signaling in Gs alpha cardiomyopathy: potential mechanism for beta-blockade in heart failure.
Heart Failure
Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy.
Heart Failure
Subcellular compartmentalization of Gs alpha in cardiac myocytes and its redistribution in heart failure.
Heart Failure
[Molecular mechanism underlying the development of heart failure mediated by heterotrimeric G protein signaling]
Hemangioma, Cavernous, Central Nervous System
Cloning of the murine Krit1 cDNA reveals novel mammalian 5' coding exons.
Hemangioma, Cavernous, Central Nervous System
KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis.
Hematologic Neoplasms
GTPase regulator associated with the focal adhesion kinase (GRAF) transcript was down-regulated in patients with myeloid malignancies.
Hepatitis B
GTPase activity is not essential for the interferon-inducible MxA protein to inhibit the replication of hepatitis B virus.
Hepatitis C
A single nucleotide polymorphism in activated cdc42 associated tyrosine kinase 1 influences the interferon therapy in hepatitis C patients.
Hepatitis C
Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M.
Hepatitis C
IQGAP2 is a novel interferon-alpha antiviral effector gene acting non-conventionally through the NF-?B pathway.
Hepatitis C
Supporting Role for GTPase Rab27a in Hepatitis C Virus RNA Replication through a Novel miR-122-Mediated Effect.
Hepatitis C
The Inflammasome Components NLRP3 and ASC Act in Concert with IRGM To Rearrange the Golgi Apparatus during Hepatitis C Virus Infection.
Hepatitis E
Identification of the interferon-inducible GTPase GBP1 as major restriction factor for the Hepatitis E virus.
Hereditary Sensory and Motor Neuropathy
Early onset severe and late-onset mild Charcot-Marie-Tooth disease with mitofusin 2 (MFN2) mutations.
Herpes Simplex
Herpes Simplex Virus Type 1 Neuronal Infection Perturbs Golgi Apparatus Integrity through Activation of Src Tyrosine Kinase and Dyn-2 GTPase.
Herpes Simplex
MiR-199a Inhibits Secondary Envelopment of Herpes Simplex Virus-1 Through the Downregulation of Cdc42-specific GTPase Activating Protein Localized in Golgi Apparatus.
heterotrimeric g-protein gtpase deficiency
Accelerated transition from the double-positive to single-positive thymocytes in G alpha i2-deficient mice.
heterotrimeric g-protein gtpase deficiency
Conditional, tissue-specific expression of Q205L G alpha i2 in vivo mimics insulin action.
heterotrimeric g-protein gtpase deficiency
Crystal structure of Rnd3/RhoE: functional implications.
heterotrimeric g-protein gtpase deficiency
Heterogeneous mutations in the gene encoding the alpha-subunit of the stimulatory G protein of adenylyl cyclase in Albright hereditary osteodystrophy.
heterotrimeric g-protein gtpase deficiency
Human platelet Galphaq deficiency is associated with decreased Galphaq gene expression in platelets but not neutrophils.
heterotrimeric g-protein gtpase deficiency
Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation.
heterotrimeric g-protein gtpase deficiency
Immunochemical analysis of the alpha-subunit of the stimulatory G-protein of adenylyl cyclase in patients with Albright's hereditary osteodystrophy.
heterotrimeric g-protein gtpase deficiency
Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gs alpha deficiency.
heterotrimeric g-protein gtpase deficiency
Induction of Galphaq-specific antisense RNA in vivo causes increased body mass and hyperadiposity.
heterotrimeric g-protein gtpase deficiency
Mutations in exon 7 of the GTP-binding protein Gs alpha were not a common cause of pseudohypoparathyroidism with Albright's hereditary osteodystrophy in Japanese.
heterotrimeric g-protein gtpase deficiency
Phosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activity.
heterotrimeric g-protein gtpase deficiency
RAC2 GTPase deficiency and myeloid cell dysfunction in human and mouse.
heterotrimeric g-protein gtpase deficiency
Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo.
Histiocytoma, Malignant Fibrous
Proteomic signatures corresponding to histological classification and grading of soft-tissue sarcomas.
Huntington Disease
Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease.
Huntington Disease
Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity.
Hyperparathyroidism, Primary
Parathyroid-targeted overexpression of Regulator of G-Protein Signaling 5 (R GS5) causes hyperparathyroidism in transgenic mice.
Hypersensitivity
GIMAP GTPase family genes: potential modifiers in autoimmune diabetes, asthma, and allergy.
Hypersensitivity
Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence.
Hypersensitivity
The RHO1-specific GTPase-activating protein LRG1 regulates polar tip growth in parallel to Ndr kinase signaling in Neurospora.
Hypertension
Deletion of STAT5a/b in vascular smooth muscle abrogates the male bias in hypoxic pulmonary hypertension in mice: implications in the human disease.
Hypertension
Enhanced expression of Gi proteins in non-hypertrophic hearts from rats with hypertension-induced by L-NAME treatment.
Hypertension
Polymorphisms in the RAC1 gene are associated with hypertension risk factors in a Chilean pediatric population.
Hypertension
Structural and functional analysis of the regulator of g protein signaling 2-g?q complex.
Hypertension, Portal
GIMAP5 maintains liver endothelial cell homeostasis and prevents portal hypertension.
Hyperthyroidism
McCune-Albright syndrome associated with non-autoimmune type of hyperthyroidism with development of thyrotoxic crisis.
Hyperthyroidism
Membrane-Bound and cytosolic forms of heterotrimeric G proteins in young and adult rat myocardium: influence of neonatal hypo- and hyperthyroidism.
Hyperthyroidism
Oncogenic potential of a mutant human thyrotropin receptor expressed in FRTL-5 cells.
Hyperthyroidism
Thyroid status affects the rat cardiac beta-adrenoceptor system transiently and time-dependently.
Hypertrophy, Left Ventricular
Decreased Gs alpha mRNA levels accompany the fall in Gs and adenylyl cyclase activities in compensated left ventricular hypertrophy. In heart failure, only the impairment in adenylyl cyclase activation progresses.
Hypertrophy, Left Ventricular
RGS4 reduces contractile dysfunction and hypertrophic gene induction in Galpha q overexpressing mice.
Hypobetalipoproteinemias
Insights from human congenital disorders of intestinal lipid metabolism.
Hypocalcemia
Familial Albright's hereditary osteodystrophy with hypoparathyroidism: normal structural Gs alpha gene.
Hypoglycemia
Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gs alpha deficiency.
Hypokalemic Periodic Paralysis
Autonomously functioning thyroid nodule associated with thyrotoxic periodic paralysis.
Hypoparathyroidism
Familial Albright's hereditary osteodystrophy with hypoparathyroidism: normal structural Gs alpha gene.
Hypothyroidism
Congenital isolated central hypothyroidism: Novel mutations and their functional implications.
Hypothyroidism
Membrane-Bound and cytosolic forms of heterotrimeric G proteins in young and adult rat myocardium: influence of neonatal hypo- and hyperthyroidism.
Ileal Diseases
Clinical and Genetic Risk Factors for Perianal Crohn's Disease in a Population-Based Cohort.
Infections
A role for endoplasmic reticulum exit sites (ERES) in foot-and-mouth disease virus infection.
Infections
Activation of Ran GTPase by a Legionella Effector Promotes Microtubule Polymerization, Pathogen Vacuole Motility and Infection.
Infections
Adenovirus infection of myocardial cells induces an enhanced sensitivity to beta-adrenergic agonists by increasing the concentration of the stimulatory G-protein.
Infections
Association of autophagy-related IRGM polymorphisms with latent versus active tuberculosis infection in a Chinese population.
Infections
Autophagy induction by the pathogen receptor NECTIN4 and sustained autophagy contribute to peste des petits ruminants virus infectivity.
Infections
Brucella melitensis, B. neotomae and B. ovis elicit common and distinctive macrophage defense transcriptional responses.
Infections
Caveolin-1-dependent infectious entry of human papillomavirus type 31 in human keratinocytes proceeds to the endosomal pathway for pH-dependent uncoating.
Infections
Colletotrichum orbiculare Regulates Cell Cycle G1/S Progression via a Two-Component GAP and a GTPase to Establish Plant Infection.
Infections
Comprehensive profiling of EBV gene expression in nasopharyngeal carcinoma through paired-end transcriptome sequencing.
Infections
Dissemination of lymphocytic choriomeningitis virus from the gastric mucosa requires G protein-coupled signaling.
Infections
Divergent Evolution of Legionella RCC1 Repeat Effectors Defines the Range of Ran GTPase Cycle Targets.
Infections
Endosomal maturation, Rab7 GTPase and phosphoinositides in African swine fever virus entry.
Infections
ESCRT-0 Component Hrs Promotes Macropinocytosis of Kaposi's Sarcoma-Associated Herpesvirus in Human Dermal Microvascular Endothelial Cells.
Infections
Experimental studies on the pathogenesis of infections due to Pseudomonas aeruginosa: direct evidence for toxin production during Pseudomonas infection of burned skin tissues.
Infections
Expression profiling of genes involved in the biotrophic colonisation of Coffea arabica leaves by Hemileia vastatrix
Infections
Functional IRGM polymorphism is associated with language impairment in glioma and upregulates cytokine expressions.
Infections
Gene expression profile of CD4+ T cells reveals an interferon signaling suppression associated with progression of experimental Schistosoma japonicum infection.
Infections
Genetic analysis of Leishmania donovani tropism using a naturally attenuated cutaneous strain.
Infections
Glucose-6-Phosphate Dehydrogenase Enhances Antiviral Response through Downregulation of NADPH Sensor HSCARG and Upregulation of NF-?B Signaling.
Infections
GTPase Activity of MxB Contributes to Its Nuclear Location, Interaction with Nucleoporins and Anti-HIV-1 Activity.
Infections
Herpes Simplex Virus Type 1 Neuronal Infection Perturbs Golgi Apparatus Integrity through Activation of Src Tyrosine Kinase and Dyn-2 GTPase.
Infections
Host factors associated with the Sindbis virus RNA-dependent RNA polymerase: a role for G3BP1 and G3BP2 in virus replication.
Infections
IIGP1, an interferon-gamma-inducible 47-kDa GTPase of the mouse, showing cooperative enzymatic activity and GTP-dependent multimerization.
Infections
Immune-related GTPase M (IRGM1) regulates neuronal autophagy in a mouse model of stroke.
Infections
Induction of interleukin-11 mediated by RhoA GTPase during human cytomegalovirus lytic infection.
Infections
Infection of neuroretinal cells in vitro by avian sarcoma viruses UR1 and UR2: transformation, cell growth stimulation, and changes in transducin levels.
Infections
Infectious bursal disease virus uptake involves macropinocytosis and trafficking to early endosomes in a Rab5-dependent manner.
Infections
Inhibition of opiate receptor-mediated signal transmission by rabies virus in persistently infected NG-108-15 mouse neuroblastoma-rat glioma hybrid cells.
Infections
Intracellular invasion by Orientia tsutsugamushi is mediated by integrin signaling and actin cytoskeleton rearrangements.
Infections
IQGAP2 is a novel interferon-alpha antiviral effector gene acting non-conventionally through the NF-?B pathway.
Infections
Irgm1 knockout indirectly inhibits regeneration after skeletal muscle injury in mice.
Infections
Legionella effector AnkX displaces the switch II region for Rab1b phosphocholination.
Infections
Legionella hijacks the host Golgi-to-ER retrograde pathway for the association of Legionella-containing vacuole with the ER.
Infections
Listeria monocytogenes antagonizes the human GTPase Cdc42 to promote bacterial spread.
Infections
Loss of the interferon-?-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection.
Infections
LvCdc42 is a potential negative regulator of Lvp53 in Litopenaeus vannamei exposed to Vibrio alginolyticus stress.
Infections
Mechanism of action of Pseudomonas aeruginosa exotoxin A in experimental mouse infections: adenosine diphosphate ribosylation of elongation factor 2.
Infections
Mediation of Interleukin-23 and Tumor Necrosis Factor-Driven Reactive Arthritis by Chlamydia-Infected Macrophages in SKG Mice.
Infections
Mx1 of black carp functions importantly in the antiviral innate immune response.
Infections
Nitric oxide-mediated intracellular growth restriction of pathogenic Rhodococcus equi can be prevented by iron.
Infections
PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.
Infections
Proteomics and Functional Analyses of Pepper Abscisic Acid-Responsive 1 (ABR1), Which Is Involved in Cell Death and Defense Signaling.
Infections
Pseudomonas fluorescens and Trichoderma asperellum Enhance Expression of G? Subunits of the Pea Heterotrimeric G-protein during Erysiphe pisi Infection.
Infections
Quantitative Proteomics Reveals the Dynamics of Protein Phosphorylation in Human Bronchial Epithelial Cells during Internalization, Phagosomal Escape, and Intracellular Replication of Staphylococcus aureus.
Infections
Rare variant MX1 alleles increase human susceptibility to zoonotic H7N9 influenza virus.
Infections
Regulation of Trypanosoma cruzi invasion of nonphagocytic cells by the endocytically active GTPases dynamin, Rab5, and Rab7.
Infections
RhoB is a component of the human cytomegalovirus assembly complex and is required for efficient viral production.
Infections
RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway.
Infections
Salmonella exploits Arl8B-directed kinesin activity to promote endosome tubulation and cell-to-cell transfer.
Infections
Small rho GTPases and cholesterol biosynthetic pathway intermediates in African swine fever virus infection.
Infections
SPIKE1 Activates the GTPase ROP6 to Guide the Polarized Growth of Infection Threads in Lotus japonicus.
Infections
Structure of the UreD-UreF-UreG-UreE complex in Helicobacter pylori: a model study.
Infections
Study of vaccinia and cowpox viruses' replication in Rac1-N17 dominant-negative cells.
Infections
Temporal SILAC-based quantitative proteomics identifies host factors involved in chikungunya virus replication.
Infections
The Salmonella effectors SseF and SseG inhibit Rab1A-mediated autophagy to facilitate intracellular bacterial survival and replication.
Infections
The E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance.
Infections
The IFN-inducible Golgi- and endoplasmic reticulum- associated 47-kDa GTPase IIGP is transiently expressed during listeriosis.
Infections
The immunity-related GTPase Irgm3 relieves endoplasmic reticulum stress response during coxsackievirus B3 infection via a PI3K/Akt dependent pathway.
Infections
The Inflammasome Components NLRP3 and ASC Act in Concert with IRGM To Rearrange the Golgi Apparatus during Hepatitis C Virus Infection.
Infections
The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation.
Infections
The tig1 histone deacetylase complex regulates infectious growth in the rice blast fungus Magnaporthe oryzae.
Infections
The Type IV Secretion System Effector Protein CirA Stimulates the GTPase Activity of RhoA and Is Required for Virulence in a Mouse Model of Coxiella burnetii Infection.
Infections
TLR adaptor MyD88 is essential for pathogen control during oral toxoplasma gondii infection but not adaptive immunity induced by a vaccine strain of the parasite.
Infections
Transcriptional response of bean bug (Riptortus pedestris) upon infection with entomopathogenic fungus, Beauveria bassiana JEF-007.
Infections
Transducin ?-like 1 X-linked receptor 1 (TBLR1) affects RGNNV infection through negative regulation of interferon immune response in orange-spotted grouper, Epinephelus coioides.
Infections
Ulk1 Governs Nerve Growth Factor/TrkA Signaling by Mediating Rab5 GTPase Activation in Porcine Hemagglutinating Encephalomyelitis Virus-Induced Neurodegenerative Disorders.
Infections
[Protective immunity of Cs-Rho GtPase recombinant protein against Clonorchis sinensis infection]
Infertility
Characterization of a fission yeast gene, gpa2, that encodes a G alpha subunit involved in the monitoring of nutrition.
Infertility, Male
Transcriptional alterations of genes related to fertility decline in male rats induced by chronic sleep restriction.
Inflammatory Bowel Diseases
Association between variants of the autophagy related gene--IRGM and susceptibility to Crohn's disease and ulcerative colitis: a meta-analysis.
Inflammatory Bowel Diseases
Emerging views of mitophagy in immunity and autoimmune diseases.
Inflammatory Bowel Diseases
Insufficient evidence for association of NOD2/CARD15 or other inflammatory bowel disease-associated markers on GVHD incidence or other adverse outcomes in T-replete, unrelated donor transplantation.
Inflammatory Bowel Diseases
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Inflammatory Bowel Diseases
NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients.
Inflammatory Bowel Diseases
PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.
Inflammatory Bowel Diseases
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Inflammatory Breast Neoplasms
A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype.
Inflammatory Breast Neoplasms
Caveolin-1 Mediates Inflammatory Breast Cancer Cell Invasion via the Akt1 Pathway and RhoC GTPase.
Inflammatory Breast Neoplasms
Macrophages Enhance Migration in Inflammatory Breast Cancer Cells via RhoC GTPase Signaling.
Inflammatory Breast Neoplasms
Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer.
Inflammatory Breast Neoplasms
Regulation of inflammatory breast cancer cell invasion through Akt1/PKB? phosphorylation of RhoC GTPase.
Inflammatory Breast Neoplasms
RhoC GTPase Is a Potent Regulator of Glutamine Metabolism and N-Acetylaspartate Production in Inflammatory Breast Cancer Cells.
Inflammatory Breast Neoplasms
RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype.
Inflammatory Breast Neoplasms
WISP3 and RhoC guanosine triphosphatase cooperate in the development of inflammatory breast cancer.
Influenza, Human
A Comprehensive Review on the Interaction Between the Host GTPase Rab11 and Influenza A Virus.
Influenza, Human
Chemical-controlled Activation of Antiviral Myxovirus Resistance Protein 1.
Influenza, Human
Comprehensive profiling of EBV gene expression in nasopharyngeal carcinoma through paired-end transcriptome sequencing.
Influenza, Human
Dynamin-like MxA GTPase: structural insights into oligomerization and implications for antiviral activity.
Influenza, Human
Enzymatic characterization of interferon-induced antiviral GTPases murine Mx1 and human MxA proteins.
Influenza, Human
Influenza Virus Induces Cholesterol-Enriched Endocytic Recycling Compartments for Budozone Formation via Cell Cycle-Independent Centrosome Maturation.
Influenza, Human
Influenza Virus Susceptibility of Wild-Derived CAST/EiJ Mice Results from Two Amino Acid Changes in the MX1 Restriction Factor.
Influenza, Human
Interferon-inducible mouse Mx1 protein that confers resistance to influenza virus is GTPase.
Influenza, Human
Mx1 GTPase accumulates in distinct nuclear domains and inhibits influenza A virus in cells that lack promyelocytic leukaemia protein nuclear bodies.
Influenza, Human
MxA GTPase: oligomerization and GTP-dependent interaction with viral RNP target structures.
Influenza, Human
Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein.
Influenza, Human
Role of GTPase activity of murine Mx1 protein in nuclear localization and anti-influenza virus activity.
Influenza, Human
Simvastatin modulates cellular components in influenza A virus-infected cells.
Influenza, Human
Structural basis of oligomerization in the stalk region of dynamin-like MxA.
Influenza, Human
Switch in antiviral specificity of a GTPase upon translocation from the cytoplasm to the nucleus.
Influenza, Human
Unique ability of pandemic influenza to downregulate the genes involved in neuronal disorders.
Influenza, Human
[Mechanism underlying the anterograde transport of the influenza A virus transmembrane proteins and genome in host cytoplasm].
Insulin Resistance
Ablation of ALCAT1 Mitigates Hypertrophic Cardiomyopathy through Effects on Oxidative Stress and Mitophagy.
Insulin Resistance
Conditional, tissue-specific expression of Q205L G alpha i2 in vivo mimics insulin action.
Insulin Resistance
Ethanol feeding impairs insulin-stimulated glucose uptake in isolated rat skeletal muscle: role of Gs alpha and cAMP.
Insulin Resistance
Galpha(i2) enhances insulin signaling via suppression of protein-tyrosine phosphatase 1B.
Insulin Resistance
Rac1 muscle knockout exacerbates the detrimental effect of high-fat diet on insulin-stimulated muscle glucose uptake independently of Akt.
Insulinoma
Absence of mutations in the Gs alpha and Gi2 alpha genes in sporadic parathyroid adenomas and insulinomas.
Insulinoma
Gs alpha--identification of a gene highly expressed by insulinoma and other endocrine tumors.
Intellectual Disability
A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory.
Intellectual Disability
Central Nervous System Functions of PAK Protein Family: From Spine Morphogenesis to Mental Retardation.
Intellectual Disability
Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD.
Intellectual Disability
Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the TGN.
Intellectual Disability
Role of a heterotrimeric G-protein, Gi2, in the corticogenesis: possible involvement in periventricular nodular heterotopia and intellectual disability.
Ischemic Stroke
CID1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neurologic deficits and inhibits reactive astrogliosis in rat ischemic stroke.
Ischemic Stroke
Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke.
Kidney Neoplasms
Inadequate activation of the GTPase RhoA contributes to the lack of fibronectin matrix assembly in von Hippel-Lindau protein-defective renal cancer cells.
Kidney Neoplasms
Leptin promotes invasiveness of murine renal cancer cells via extracellular signal-regulated kinases and rho dependent pathway.
Learning Disabilities
The segregation of different submicroscopic imbalances underlying the clinical variability associated with a familial karyotypically balanced translocation.
Leber Congenital Amaurosis
Leber congenital amaurosis caused by an RPGRIP1 mutation shows treatment potential.
Leber Congenital Amaurosis
Phenotypic variation and genotype-phenotype discordance in canine cone-rod dystrophy with an RPGRIP1 mutation.
Legionnaires' Disease
Divergent Evolution of Legionella RCC1 Repeat Effectors Defines the Range of Ran GTPase Cycle Targets.
Legionnaires' Disease
Legionella effector AnkX displaces the switch II region for Rab1b phosphocholination.
Legionnaires' Disease
Structure of the GTPase and GDI domains of FeoB, the ferrous iron transporter of Legionella pneumophila.
Legionnaires' Disease
The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b.
Leiomyosarcoma
Proteomic signatures corresponding to histological classification and grading of soft-tissue sarcomas.
Leprosy
mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1.
Leukemia
A GTPase-activating protein binds STAT3 and is required for IL-6-induced STAT3 activation and for differentiation of a leukemic cell line.
Leukemia
A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein.
Leukemia
Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells.
Leukemia
Functionally nonequivalent interactions of guanosine 5'-triphosphate, inosine 5'-triphosphate, and xanthosine 5'-triphosphate with the retinal G-protein, transducin, and with Gi-proteins in HL-60 leukemia cell membranes.
Leukemia
Generation of SUMO-1 modified proteins in E. coli: towards understanding the biochemistry/structural biology of the SUMO-1 pathway.
Leukemia
Improvement of cholera toxin-catalyzed ADP-ribosylation by endogenous ADP-ribosylation factor from bovine brain provides evidence for an unchanged amount of Gs alpha in failing human myocardium.
Leukemia
Interferon-induced antiviral Mx1 GTPase is associated with components of the SUMO-1 system and promyelocytic leukemia protein nuclear bodies.
Leukemia
Mitofusin-2 mediates doxorubicin sensitivity and acute resistance in Jurkat leukemia cells.
Leukemia
Pleiotropic role of Rac in mast cell activation revealed by a cell permeable Bordetella dermonecrotic fusion toxin.
Leukemia
PLEKHG2 promotes heterotrimeric G protein ??-stimulated lymphocyte migration via Rac and Cdc42 activation and actin polymerization.
Leukemia
Retinoic acid-mediated decrease of G (alpha S) protein expression: involvement of G (alpha S) in the differentiation of HL-60 myeloid cells.
Leukemia
The GTPase domain of Galphao contributes to the functional interaction of Galphao with the promyelocytic leukemia zinc finger protein.
Leukemia
The N-terminal domain of the non-receptor tyrosine kinase ABL confers protein instability and suppresses tumorigenesis.
Leukemia, Erythroblastic, Acute
Differential expression of Ran GTPase during HMBA-induced differentiation in murine erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Early growth response transcription factor EGR-1 regulates Galphaq gene in megakaryocytic cells.
Leukemia, Erythroblastic, Acute
Identification and subcellular localization of human rab5b, a new member of the ras-related superfamily of GTPases.
Leukemia, Erythroblastic, Acute
Induction of erythroid differentiation by altered Galpha16 activity as detected by a reporter gene assay in MB-02 cells.
Leukemia, Erythroblastic, Acute
Phorbol 12-myristate 13-acetate (PMA) responsive sequence in Galphaq promoter during megakaryocytic differentiation. Regulation by EGR-1 and MAP kinase pathway.
Leukemia, Erythroblastic, Acute
The P2U purinoceptor obligatorily engages the heterotrimeric G protein G16 to mobilize intracellular Ca2+ in human erythroleukemia cells.
Leukemia, Lymphocytic, Chronic, B-Cell
Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Rho and Rap guanosine triphosphatase signaling in B cells and chronic lymphocytic leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Analysis of mutations and expression of GAP-related domain of the neurofibromatosis type 1 (NF1) gene in the progression of chronic myelogenous leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Bone marrow-derived mesenchymal stromal cells promote resistance to tyrosine kinase inhibitors in chronic myeloid leukemia via the IL-7/JAK1/STAT5 pathway.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Concomitant presence of JAK2V617F mutation and BCR?ABL translocation in two patients: A new entity or a variant of myeloproliferative neoplasms (Case report).
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Detection of Chromosomal Translocation in Hematologic Malignancies by a Novel DNA-Based Looped Ligation Assay (LOLA).
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
New alternative splicing BCR/ABL-OOF shows an oncogenic role by lack of inhibition of BCR GTPase activity and an increased of persistence of Rac activation in chronic myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
p210(Bcr-Abl) desensitizes Cdc42 GTPase signaling for SDF-1alpha-directed migration in chronic myeloid leukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
RalA, a GTPase targeted by miR?181a, promotes transformation and progression by activating the Ras?related signaling pathway in chronic myelogenous leukemia.
Leukemia, Myeloid
Gs alpha availability to cholera toxin-catalysed ADP-ribosylation is decreased in membranes of retinoic acid-treated leukemic cell lines HL-60 and THP-1. A posttranslational effect.
Leukemia, Myeloid, Acute
Genetic and pharmacologic evidence implicating the p85 alpha, but not p85 beta, regulatory subunit of PI3K and Rac2 GTPase in regulating oncogenic KIT-induced transformation in acute myeloid leukemia and systemic mastocytosis.
Leukemia, Myeloid, Acute
High expression of GTPase regulator associated with the focal adhesion kinase (GRAF) is a favorable prognostic factor in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Rac1 signaling protects monocytic AML cells expressing the MLL-AF9 oncogene from caspase-mediated apoptotic death.
Leukemia, Myelomonocytic, Juvenile
Leukemic potential of doubly mutant Nf1 and Wv hematopoietic cells.
Leukoplakia
Recurrent genomic alterations in sequential progressive leukoplakia and oral cancer: drivers of oral tumorigenesis?
Lipoma
RFLP analysis of human chromosome 11 region q13 in multiple symmetric lipomatosis and multiple endocrine neoplasia type 1-associated lipomas.
Listeriosis
The IFN-inducible Golgi- and endoplasmic reticulum- associated 47-kDa GTPase IIGP is transiently expressed during listeriosis.
Liver Diseases
The immunity-related GTPase M rs13361189 variant does not increase the risk for prevalent or incident steatosis; results from the Framingham Heart Study.
Liver Diseases
Variants in the autophagy-related gene IRGM confer susceptibility to non-alcoholic fatty liver disease by modulating lipophagy.
Liver Neoplasms
Aberrant amino acid signaling promotes growth and metastasis of hepatocellular carcinomas through Rab1A-dependent activation of mTORC1 by Rab1A.
Liver Neoplasms
Tensins are versatile regulators of Rho GTPase signalling and cell adhesion.
Low Tension Glaucoma
Evidence for RPGRIP1 gene as risk factor for primary open angle glaucoma.
Lung Injury
The GTPase Rab1 Is Required for NLRP3 Inflammasome Activation and Inflammatory Lung Injury.
Lung Neoplasms
Aberrant expression of Rab1A and its prognostic significance in human colorectal cancer.
Lung Neoplasms
AGO2 promotes tumor progression in KRAS-driven mouse models of non-small cell lung cancer.
Lung Neoplasms
ARHGAP6 regulates the proliferation, migration and invasion of lung cancer cells.
Lung Neoplasms
Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis.
Lung Neoplasms
Caveolin-1 promotes radioresistance via IRGM-regulated autophagy in lung cancer.
Lung Neoplasms
Diagnostic and prognostic value of blood samples for KRAS mutation identification in lung cancer: a meta-analysis.
Lung Neoplasms
Expression of Rab1A is upregulated in human lung cancer and associated with tumor size and T stage.
Lung Neoplasms
Fragile Histidine Triad Mediated Tumor Suppression of Lung Cancer by Targeting Multiple Components of the Ras/Rho GTPase Molecular Switch.
Lung Neoplasms
GPR78 promotes lung cancer cell migration and metastasis by activation of G?q-Rho GTPase pathway.
Lung Neoplasms
Heterotrimeric G-protein, G?16, is a critical downstream effector of non-canonical Wnt signaling and a potent inhibitor of transformed cell growth in non small cell lung cancer.
Lung Neoplasms
In Silico Screening of Mutated K-Ras Inhibitors from Malaysian Typhonium flagelliforme for Non-Small Cell Lung Cancer.
Lung Neoplasms
Inhibitory heterotrimeric GTP-binding proteins inhibit hydrogen peroxide-induced apoptosis by up-regulation of Bcl-2 via NF-kappaB in H1299 human lung cancer cells.
Lung Neoplasms
Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer.
Lung Neoplasms
MicroRNA?4500 suppresses tumor progression in non?small cell lung cancer by regulating STAT3.
Lung Neoplasms
MiR-124a Regulates Extracellular Vesicle Release by Targeting GTPase Rabs in Lung Cancer.
Lung Neoplasms
Novel transmembrane GTPase of non-small cell lung cancer identified by mRNA differential display.
Lung Neoplasms
Rab8 GTPase regulates Klotho-mediated inhibition of cell growth and progression by directly modulating its surface expression in human non-small cell lung cancer.
Lung Neoplasms
Ran GTPase induces EMT and enhances invasion in non-small cell lung cancer cells through activation of PI3K-AKT pathway.
Lung Neoplasms
Stimulatory heterotrimeric G protein augments gamma ray-induced apoptosis by up-regulation of Bak expression via CREB and AP-1 in H1299 human lung cancer cells.
Lung Neoplasms
Suppression of Tobacco Carcinogen-Induced Lung Tumorigenesis by Aerosol-Delivered Glycerol Propoxylate Triacrylate-Spermine Copolymer/Short Hairpin Rab25 RNA Complexes in Female A/J Mice.
Lung Neoplasms
Targeted delivery of Rab26 siRNA with precisely tailored DNA prism for lung cancer therapy.
Lung Neoplasms
The RAS-related GTPase RHOB confers resistance to EGFR-tyrosine kinase inhibitors in non-small-cell lung cancer via an AKT-dependent mechanism.
Lupus Erythematosus, Systemic
Emerging views of mitophagy in immunity and autoimmune diseases.
Lupus Erythematosus, Systemic
Podocytes and autophagy: a potential therapeutic target in lupus nephritis.
Lupus Nephritis
Podocytes and autophagy: a potential therapeutic target in lupus nephritis.
Lymphatic Metastasis
Aberrant expression of Rab1A and its prognostic significance in human colorectal cancer.
Lymphatic Metastasis
Pooled analysis of prognostic value and clinical significance of Rab1A expression in human solid tumors.
Lymphatic Metastasis
Rab1A promotes cell proliferation and migration by upregulating Gli1 in colorectal cancer.
Lymphatic Metastasis
Reduced RhoA expression enhances breast cancer metastasis with a concomitant increase in CCR5 and CXCR4 chemokines signaling.
Lymphatic Metastasis
RhoC GTPase expression as a potential marker of lymph node metastasis in squamous cell carcinomas of the head and neck.
Lymphoma
A novel Gs alpha mutant in a patient with Albright hereditary osteodystrophy uncouples cell surface receptors from adenylyl cyclase.
Lymphoma
A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma.
Lymphoma
Activated Gs alpha but not Gi alpha prevents the thermal inactivation of adenylyl cyclase in plasma membranes derived from S49 lymphoma cells.
Lymphoma
Adenylate cyclase inhibition and GTPase stimulation by somatostatin in S49 lymphoma cyc- variants are prevented by islet-activating protein.
Lymphoma
Altered Pattern of Immunoglobulin Hypermutation in Mice Deficient in Slip-GC Protein.
Lymphoma
Cardiac adenylyl cyclase, beta-adrenergic receptors, and G proteins in salt-sensitive hypertension.
Lymphoma
Chronic ethanol treatment increases expression of inhibitory G-proteins and reduces adenylylcyclase activity in the central nervous system of two lines of ethanol-sensitive mice.
Lymphoma
Coronary artery stenosis in rats affects beta-adrenergic receptor signaling in myocytes.
Lymphoma
Decreased incorporation of the photoaffinity probe 8N3-[gamma-32P]-GTP into a 45kD protein in lung tumors.
Lymphoma
Development and Clinical Utility of a Blood-Based Test Service for the Rapid Identification of Actionable Mutations in Non-Small Cell Lung Carcinoma.
Lymphoma
Effect of (211)At alpha-particle irradiation on expression of selected radiation responsive genes in human lymphocytes.
Lymphoma
Effect of ethanol treatment on the activity and amount of stimulatory GTP-binding regulatory protein (Gs) in S49 murine lymphoma cells and human erythrocytes.
Lymphoma
Expression and characterization of the long and short splice variants of GS alpha in S49 cyc- cells.
Lymphoma
Expression of cDNAs for G proteins in Escherichia coli. Two forms of Gs alpha stimulate adenylate cyclase.
Lymphoma
Expression of the Rho-family GTPase gene RHOF in lymphocyte subsets and malignant lymphomas.
Lymphoma
Hematopoietic recovery after IEV chemotherapy for malignant lymphoma followed by different cytokines can be monitored by analysis of Galpha 16 and CD34.
Lymphoma
Identification and characterization of the 35-kDa beta subunit of guanine-nucleotide-binding proteins by an antiserum raised against transducin.
Lymphoma
Immunoelectron microscopic identification of cytoplasmic and nuclear Gs alpha in S49 lymphoma cells.
Lymphoma
Improvement of cholera toxin-catalyzed ADP-ribosylation by endogenous ADP-ribosylation factor from bovine brain provides evidence for an unchanged amount of Gs alpha in failing human myocardium.
Lymphoma
Mechanisms of autoregulation of C3G, activator of the GTPase Rap1, and its catalytic deregulation in lymphomas.
Lymphoma
Pertussis toxin inhibition of B cell and macrophage responses to bacterial lipopolysaccharide.
Lymphoma
Somatostatin-induced stimulation of a high-affinity GTPase in membranes of S49 lymphoma cyc- and H21a variants.
Lymphoma
Speckled-like pattern in the germinal center (SLIP-GC): A nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells.
Lymphoma
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Lymphoma, B-Cell
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Lymphoma, B-Cell
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Lymphoma, B-Cell
Transducin ?-like protein 1 controls multiple oncogenic networks in diffuse large B-cell lymphoma.
Lymphoma, Follicular
Detection of Chromosomal Translocation in Hematologic Malignancies by a Novel DNA-Based Looped Ligation Assay (LOLA).
Lymphoma, Follicular
Oncogenic Rag GTPase signaling enhances B cell activation and drives follicular lymphoma sensitive to pharmacological inhibition of mTOR.
Lymphoma, Large B-Cell, Diffuse
Transducin ?-like protein 1 controls multiple oncogenic networks in diffuse large B-cell lymphoma.
Lymphoma, T-Cell
A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma.
Lymphoma, T-Cell
Roles of GTP and Rho GTPases in pancreatic islet beta cell function and dysfunction.
Lymphoma, T-Cell
The inhibition of the effect and mechanism of vascular intimal hyperplasia in Tiam1 knockout mice.
Lymphoma, T-Cell
The Tiam1 Guanine Nucleotide Exchange Factor is Auto-inhibited by its Pleckstrin Homology Coiled-Coil Extension Domain.
Lymphoma, T-Cell
The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion.
Lymphoma, T-Cell
Timing of Novel Drug 1A-116 to Circadian Rhythms Improves Therapeutic Effects against Glioblastoma.
Macular Degeneration
Cone cGMP-gated channel mutations and clinical findings in patients with achromatopsia, macular degeneration, and other hereditary cone diseases.
Macular Degeneration
Exon screening of the genes encoding the beta- and gamma-subunits of cone transducin in patients with inherited retinal disease.
Magnesium Deficiency
Severe dietary magnesium deficiency does not alter levels and function of myocardial Gs alpha and Gi alpha.
Malaria
Effects of interruption of apicoplast function on malaria infection, development, and transmission.
Malaria
Expression of GIMAP1, a GTPase of the immunity-associated protein family, is not up-regulated in malaria.
Malaria
Plasmodium falciparum ARFGAP: expression and crystallization of the catalytic domain.
Mandibulofacial Dysostosis
Haploinsufficiency of a spliceosomal GTPase encoded by EFTUD2 causes mandibulofacial dysostosis with microcephaly.
Mandibulofacial Dysostosis
Mandibulofacial dysostosis with microcephaly: An expansion of the phenotype via parental survey.
Mandibulofacial Dysostosis
Novel Splice Site Pathogenic Variant of EFTUD2 Is Associated with Mandibulofacial Dysostosis with Microcephaly and Extracranial Symptoms in Korea.
Mastocytoma
Translocation of alpha subunits of stimulatory guanine nucleotide-binding proteins through stimulation of the prostacyclin receptor in mouse mastocytoma cells.
Mastocytosis, Systemic
Genetic and pharmacologic evidence implicating the p85 alpha, but not p85 beta, regulatory subunit of PI3K and Rac2 GTPase in regulating oncogenic KIT-induced transformation in acute myeloid leukemia and systemic mastocytosis.
Measles
Autophagy induction by the pathogen receptor NECTIN4 and sustained autophagy contribute to peste des petits ruminants virus infectivity.
Measles
Enzymatic characterization of interferon-induced antiviral GTPases murine Mx1 and human MxA proteins.
Measles
Rab9 GTPase is required for replication of human immunodeficiency virus type 1, filoviruses, and measles virus.
Medulloblastoma
Disruption of the ciliary GTPase Arl13b suppresses Sonic hedgehog overactivation and inhibits medulloblastoma formation.
Medulloblastoma
Role of Rac1-regulated signaling in medulloblastoma invasion. Laboratory investigation.
Megalencephaly
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Melanoma
Activation of Vav/Rho GTPase signaling by CXCL12 controls membrane-type matrix metalloproteinase-dependent melanoma cell invasion.
Melanoma
ADP-ribosylation factor 6 regulates tumor cell invasion through the activation of the MEK/ERK signaling pathway.
Melanoma
CAPN1 is a novel binding partner and regulator of the tumor suppressor NF1 in melanoma.
Melanoma
cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca(2+) homeostasis in melanoma cells.
Melanoma
Characterization of human melanoma cell lines and melanocytes by proteome analysis.
Melanoma
Clinical and pathological associations of the activating RAC1 P29S mutation in primary cutaneous melanoma.
Melanoma
IFNg-induced Irgm1 promotes tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1-dependent autophagy.
Melanoma
Inhibition of the RhoA GTPase Activity Increases Sensitivity of Melanoma Cells to UV Radiation Effects.
Melanoma
IRGM promotes melanoma cell survival through autophagy and is a promising prognostic biomarker for clinical application.
Melanoma
IRGM1 enhances B16 melanoma cell metastasis through PI3K-Rac1 mediated epithelial mesenchymal transition.
Melanoma
Irgm1 knockout indirectly inhibits regeneration after skeletal muscle injury in mice.
Melanoma
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.
Melanoma
Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis.
Melanoma
Preventing the activation or cycling of the Rap1 GTPase alters adhesion and cytoskeletal dynamics and blocks metastatic melanoma cell extravasation into the lungs.
Melanoma
RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes.
Melanoma
RAC1mutation is not a predictive biomarker for PI3'-kinase-?-selective pathway-targeted therapy.
Melanoma
Ran GTPase is an independent prognostic marker in malignant melanoma which promotes tumour cell migration and invasion.
Melanoma
Retraction Note to: cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca2+ homeostasis in melanoma cells.
Melanoma
Ric-8A gene deletion or phorbol ester suppresses tumorigenesis in a mouse model of GNAQ(Q209L)-driven melanoma.
Melanoma
Rnd3 regulation of the actin cytoskeleton promotes melanoma migration and invasive outgrowth in three dimensions.
Melanoma
Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas.
Melanoma
Targeting TBK1 Inhibits Migration and Resistance to MEK Inhibitors in Mutant NRAS Melanoma.
Melanoma
The involvement of mutant Rac1 in the formation of invadopodia in cultured melanoma cells.
Melanoma
The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion.
Melanoma
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Melanoma
The Small GTPase ARF6 Stimulates ?-Catenin Transcriptional Activity During WNT5A-Mediated Melanoma Invasion and Metastasis.
Melanoma
Upregulation of intratumoral HLA class I and peritumoral Mx1 in ulcerated melanomas.
Meningitis, Bacterial
Human guanylate binding protein-1 is a secreted GTPase present in increased concentrations in the cerebrospinal fluid of patients with bacterial meningitis.
Menkes Kinky Hair Syndrome
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Mesothelioma
Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42.
Metabolic Diseases
RRAD inhibits aerobic glycolysis, invasion, and migration and is associated with poor prognosis in hepatocellular carcinoma.
Microcephaly
Haploinsufficiency of a spliceosomal GTPase encoded by EFTUD2 causes mandibulofacial dysostosis with microcephaly.
Microcephaly
Mandibulofacial dysostosis with microcephaly: An expansion of the phenotype via parental survey.
Microcephaly
Novel Splice Site Pathogenic Variant of EFTUD2 Is Associated with Mandibulofacial Dysostosis with Microcephaly and Extracranial Symptoms in Korea.
Migraine Disorders
A study of adaptive responses in cell signaling in migraine and cluster headache: correlations between headache type and changes in gene expression.
Mitochondrial Diseases
The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases.
Mouth Neoplasms
Heterotrimeric G-protein alpha-12 (G?12) subunit promotes oral cancer metastasis.
Mouth Neoplasms
Urinary-type plasminogen activator receptor (uPAR) modulates oral cancer cell behavior with alteration in p130cas.
Multiple Endocrine Neoplasia
A pituitary specific point mutation of codon 201 of the Gs alpha gene in a pituitary adenoma of a patient with multiple endocrine neoplasia (MEN) type 1.
Multiple Endocrine Neoplasia
Association of somatotrophinomas with loss of alleles on chromosome 11 and with gsp mutations.
Multiple Endocrine Neoplasia
Gs alpha mutation may be uncommon in patients with multiple endocrine neoplasia type 1.
Multiple Endocrine Neoplasia
Rare mutations of the Gs alpha subunit gene in human endocrine tumors. Mutation detection by polymerase chain reaction-primer-introduced restriction analysis.
Multiple Endocrine Neoplasia
Study of the multiple endocrine neoplasia type 1, growth hormone-releasing hormone receptor, Gs alpha, and Gi2 alpha genes in isolated familial acromegaly.
Multiple Endocrine Neoplasia Type 1
Association of somatotrophinomas with loss of alleles on chromosome 11 and with gsp mutations.
Multiple Endocrine Neoplasia Type 1
Gs alpha mutation may be uncommon in patients with multiple endocrine neoplasia type 1.
Multiple Endocrine Neoplasia Type 1
Study of the multiple endocrine neoplasia type 1, growth hormone-releasing hormone receptor, Gs alpha, and Gi2 alpha genes in isolated familial acromegaly.
Multiple Endocrine Neoplasia Type 2b
Relatively good prognosis of multiple endocrine neoplasia type 2B in Japanese: review of cases in Japan and analysis of genetic changes in tumors.
Multiple Myeloma
DLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathway.
Multiple Myeloma
IQGAP1 plays an important role in the cell proliferation of multiple myeloma via the MAP kinase (ERK) pathway.
Multiple Myeloma
Quercetin suppresses the proliferation of multiple myeloma cells by down-regulating IQ motif-containing GTPase activating protein 1 expression and extracellular signal-regulated kinase activation.
Multiple Myeloma
Truncated protein tyrosine phosphatase receptor type O suppresses AKT signaling through IQ motif containing GTPase activating protein 1 and confers sensitivity to bortezomib in multiple myeloma.
Muscle Cramp
Antimicrobial peptide CRAMP (16-33) stalls bacterial cytokinesis by inhibiting FtsZ assembly.
Muscle Hypotonia
Impaired turnover of hyperfused mitochondria in severe axonal neuropathy due to a novel DRP1 mutation.
Muscle Spasticity
Homotypic fusion of ER membranes requires the dynamin-like GTPase atlastin.
Muscular Atrophy
Characterization of control and immobilized skeletal muscle: an overview from genetic engineering.
Muscular Atrophy
Protein synthesis in skeletal muscle of neonatal pigs is enhanced by administration of ?-hydroxy-?-methylbutyrate.
Muscular Diseases
Dynamin 2 mutations associated with human diseases impair clathrin-mediated receptor endocytosis.
Muscular Dystrophies
Analyses of beta-1 syntrophin, syndecan 2 and gem GTPase as candidates for chicken muscular dystrophy.
Muscular Dystrophies
Increase in the amount of elongation factor 2 in chicken muscular dystrophy.
Muscular Dystrophies
Sparks, signals and shock absorbers: how dystrophin loss causes muscular dystrophy.
Muscular Dystrophy, Duchenne
Muscular dystrophy in the Japanese Spitz: an inversion disrupts the DMD and RPGR genes.
Mycoses
CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex.
Myelodysplastic Syndromes
Aberrant methylation of GTPase regulator associated with the focal adhesion kinase (GRAF) promoter is an adverse prognostic factor in myelodysplastic syndrome.
Myelodysplastic Syndromes
Abnormal methylation of GRAF promoter Chinese patients with acute myeloid leukemia.
Myelodysplastic Syndromes
Assessment of growth and differentiation processes in myelodysplastic syndromes by PCR analysis of Galpha16 and 5'-lipoxygenase.
Myelodysplastic Syndromes
Screening of mutations in the additional sex combs like 1, transcriptional regulator, tumor protein p53, and KRAS proto-oncogene, GTPase/NRAS proto-oncogene, GTPase genes of patients with myelodysplastic syndrome.
Myocardial Infarction
Dietary magnesium deficiency increases Gi alpha levels in the rat heart after myocardial infarction.
Myocardial Infarction
Dynamic changes in G alpha i-2 levels in rat hearts associated with impaired heart function after myocardial infarction.
Myocardial Infarction
Expression of Gi-2 alpha and Gs alpha in myofibroblasts localized to the infarct scar in heart failure due to myocardial infarction.
Myocardial Infarction
Impaired platelet function reduces myocardial infarct size in Galphaq knock-out mice in vivo.
Myocardial Infarction
Mitochondrial autophagy and cell survival is regulated by the circadian Clock gene in cardiac myocytes during ischemic stress.
Myocardial Ischemia
Regional myocardial downregulation of the inhibitory guanosine triphosphate-binding protein (Gi alpha 2) and beta-adrenergic receptors in a porcine model of chronic episodic myocardial ischemia.
Myopathies, Structural, Congenital
Dynamin GTPase regulation is altered by PH domain mutations found in centronuclear myopathy patients.
Myopathies, Structural, Congenital
Loss of Dynamin 2 GTPase function results in microcytic anaemia.
Myopathies, Structural, Congenital
Mice lacking microRNA 133a develop dynamin 2-dependent centronuclear myopathy.
Myopathies, Structural, Congenital
Myotubularin regulates the function of the late endosome through the gram domain-phosphatidylinositol 3,5-bisphosphate interaction.
Myopia
Identification of novel X-linked gain-of-function RPGR-ORF15 mutation in Italian family with retinitis pigmentosa and pathologic myopia.
Myotoxicity
Geranylgeraniol Prevents Statin-Dependent Myotoxicity in C2C12 Muscle Cells through RAP1 GTPase Prenylation and Cytoprotective Autophagy.
Myotoxicity
Inhibition of Rab1 GTPase and endoplasmic reticulum-to-Golgi trafficking underlies statin's toxicity in rat skeletal myofibers.
Myxoma
Juxta-articular myxoma and intramuscular myxoma are two distinct entities. Activating Gs alpha mutation at Arg 201 codon does not occur in juxta-articular myxoma.
Myxoma
Odontogenic myxomas are not associated with activating mutations of the Gs alpha gene.
Myxoma
Sporadic cardiac myxomas and tumors from patients with Carney complex are not associated with activating mutations of the Gs alpha gene.
Nasopharyngeal Carcinoma
Promoter hypermethylation of Ras-related GTPase gene RRAD inactivates a tumor suppressor function in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
Rab1A promotes cancer metastasis and radioresistance through activating GSK-3?/Wnt/?-catenin signaling in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
Transducin ?-like 1 X-linked receptor 1 suppresses cisplatin sensitivity in nasopharyngeal carcinoma via activation of NF-?B pathway.
Neoplasm Metastasis
Aberrant amino acid signaling promotes growth and metastasis of hepatocellular carcinomas through Rab1A-dependent activation of mTORC1 by Rab1A.
Neoplasm Metastasis
Aberrant expression of Rab1A and its prognostic significance in human colorectal cancer.
Neoplasm Metastasis
ALEX1, a novel tumor suppressor gene, inhibits gastric cancer metastasis via the PAR-1/Rho GTPase signaling pathway.
Neoplasm Metastasis
An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism.
Neoplasm Metastasis
An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis.
Neoplasm Metastasis
ARF1 controls Rac1 signaling to regulate migration of MDA-MB-231 invasive breast cancer cells.
Neoplasm Metastasis
Circ_0000218 plays a carcinogenic role in colorectal cancer progression by regulating miR-139-3p/RAB1A axis.
Neoplasm Metastasis
Correlation of the Rac1/RhoA Pathway With Ezrin Expression in Osteosarcoma.
Neoplasm Metastasis
Dampened VEPH1 activates mTORC1 signaling by weakening the TSC1/TSC2 association in hepatocellular carcinoma.
Neoplasm Metastasis
Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis.
Neoplasm Metastasis
DLC1 suppresses distant dissemination of human hepatocellular carcinoma cells in nude mice through reduction of RhoA GTPase activity, actin cytoskeletal disruption and down-regulation of genes involved in metastasis.
Neoplasm Metastasis
DNA methylation-mediated silencing of matricellular protein dermatopontin promotes hepatocellular carcinoma metastasis by ?3?1 integrin-Rho GTPase signaling.
Neoplasm Metastasis
Endothelial Rab7 GTPase Mediates Tumor Growth and Metastasis in Lysosomal Acid Lipase Deficient Mice.
Neoplasm Metastasis
EphB3 Stimulates Cell Migration and Metastasis in a Kinase-dependent Manner through Vav2-Rho GTPase Axis in Papillary Thyroid Cancer.
Neoplasm Metastasis
Expression of Rac-1 related to tumor depth, lymph node metastasis and patient prognosis in esophageal squamous cell carcinoma.
Neoplasm Metastasis
Gallic acid inhibits gastric cancer cells metastasis and invasive growth via increased expression of RhoB, downregulation of AKT/small GTPase signals and inhibition of NF-?B activity.
Neoplasm Metastasis
GPR116, an Adhesion G-Protein-Coupled Receptor, Promotes Breast Cancer Metastasis via the G?q-p63RhoGEF-Rho GTPase Pathway.
Neoplasm Metastasis
GPR78 promotes lung cancer cell migration and metastasis by activation of G?q-Rho GTPase pathway.
Neoplasm Metastasis
Heterotrimeric G protein signaling in cancer cells with regard to metastasis formation.
Neoplasm Metastasis
Heterotrimeric G-protein alpha-12 (G?12) subunit promotes oral cancer metastasis.
Neoplasm Metastasis
High expression of Ran GTPase is associated with local invasion and metastasis of human clear cell renal cell carcinoma.
Neoplasm Metastasis
In-depth NMR characterization of Rab4a structure, nucleotide exchange and hydrolysis kinetics reveals an atypical GTPase profile.
Neoplasm Metastasis
Inhibition of RAB1A suppresses epithelial-mesenchymal transition and proliferation of triple-negative breast cancer cells.
Neoplasm Metastasis
Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization.
Neoplasm Metastasis
Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation.
Neoplasm Metastasis
IQGAP1?siRNA inhibits proliferation and metastasis of U251 and U373 glioma cell lines.
Neoplasm Metastasis
IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells.
Neoplasm Metastasis
IRGM promotes melanoma cell survival through autophagy and is a promising prognostic biomarker for clinical application.
Neoplasm Metastasis
Long Noncoding RNA MNX1 antisense RNA 1 Exerts Oncogenic Functions in Bladder Cancer by Regulating miR-218-5p/RAB1A Axis.
Neoplasm Metastasis
LyGDI functions in cancer metastasis by anchoring Rho proteins to the cell membrane.
Neoplasm Metastasis
Mass spectroscopic phosphoprotein mapping of Ral binding protein 1 (RalBP1/Rip1/RLIP76).
Neoplasm Metastasis
Metastasis Suppressors NME1 and NME2 Promote Dynamin 2 Oligomerization and Regulate Tumor Cell Endocytosis, Motility, and Metastasis.
Neoplasm Metastasis
Mutant K-RAS Promotes Invasion and Metastasis in Pancreatic Cancer Through GTPase Signaling Pathways.
Neoplasm Metastasis
P-REX1-Independent, Calcium-Dependent RAC1 Hyperactivation in Prostate Cancer.
Neoplasm Metastasis
p38{gamma} promotes breast cancer cell motility and metastasis through regulation of RhoC GTPase, cytoskeletal architecture, and a novel leading edge behavior.
Neoplasm Metastasis
Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells.
Neoplasm Metastasis
Pooled analysis of prognostic value and clinical significance of Rab1A expression in human solid tumors.
Neoplasm Metastasis
Prognostic relevance of increased Rac GTPase expression in prostate carcinomas.
Neoplasm Metastasis
Prognostic significance of TBL1XR1 in predicting liver metastasis for early stage colorectal cancer.
Neoplasm Metastasis
Prognostic significance of Tiam1 expression in papillary thyroid carcinoma.
Neoplasm Metastasis
Rab1A promotes cancer metastasis and radioresistance through activating GSK-3?/Wnt/?-catenin signaling in nasopharyngeal carcinoma.
Neoplasm Metastasis
Rab1A promotes cell proliferation and migration by upregulating Gli1 in colorectal cancer.
Neoplasm Metastasis
Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments.
Neoplasm Metastasis
Rac activation and inactivation control plasticity of tumor cell movement.
Neoplasm Metastasis
Rac2 controls tumor growth, metastasis and M1-M2 macrophage differentiation in vivo.
Neoplasm Metastasis
Ran GTPase protein promotes metastasis and invasion in pancreatic cancer by deregulating the expression of AR and CXCR4.
Neoplasm Metastasis
Ras Homolog Family Member F, Filopodia Associated Promotes Hepatocellular Carcinoma Metastasis by Altering the Metabolic Status of Cancer Cells Through RAB3D.
Neoplasm Metastasis
Reduced RhoA expression enhances breast cancer metastasis with a concomitant increase in CCR5 and CXCR4 chemokines signaling.
Neoplasm Metastasis
RhoC GTPase expression as a potential marker of lymph node metastasis in squamous cell carcinomas of the head and neck.
Neoplasm Metastasis
RhoC GTPase is required for PC-3 prostate cancer cell invasion but not motility.
Neoplasm Metastasis
RhoC Impacts the Metastatic Potential and Abundance of Breast Cancer Stem Cells.
Neoplasm Metastasis
Role of IQGAP3 in metastasis and epithelial-mesenchymal transition in human hepatocellular carcinoma.
Neoplasm Metastasis
SEC-induced activation of ANXA7 GTPase suppresses prostate cancer metastasis.
Neoplasm Metastasis
SIPA1 enhances SMAD2/3 expression to maintain stem cell features in breast cancer cells.
Neoplasm Metastasis
Specific repression of mutant K-RAS by 10-23 DNAzyme: sensitizing cancer cell to anti-cancer therapies.
Neoplasm Metastasis
Swiprosin-1 stimulates cancer invasion and metastasis by increasing the Rho family of GTPase signaling.
Neoplasm Metastasis
TBL1XR1 is involved in c-Met-mediated tumorigenesis of human nonsmall cell lung cancer.
Neoplasm Metastasis
TC10 regulates breast cancer invasion and metastasis by controlling membrane type-1 matrix metalloproteinase at invadopodia.
Neoplasm Metastasis
The effect of RhoC siRNA on the invasiveness and proliferation of human cervical cancer cell line SiHa cells.
Neoplasm Metastasis
The inhibition of the effect and mechanism of vascular intimal hyperplasia in Tiam1 knockout mice.
Neoplasm Metastasis
The Tiam1 Guanine Nucleotide Exchange Factor is Auto-inhibited by its Pleckstrin Homology Coiled-Coil Extension Domain.
Neoplasm Metastasis
The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion.
Neoplasm Metastasis
Timing of Novel Drug 1A-116 to Circadian Rhythms Improves Therapeutic Effects against Glioblastoma.
Neoplasm Metastasis
Transcriptional inhibition by CDK7/9 inhibitor SNS-032 abrogates oncogene addiction and reduces liver metastasis in uveal melanoma.
Neoplasm Metastasis
Type I collagen receptor (alpha2beta1) signaling promotes prostate cancer invasion through RhoC GTPase.
Neoplasm Metastasis
Up-regulation of T-lymphoma and metastasis gene 1 in gastric cancer and its involvement in cell invasion and migration.
Neoplasm Metastasis
Upregulation of LINC00659 expression predicts a poor prognosis and promotes migration and invasion of gastric cancer cells.
Neoplasm Metastasis
[Effect of GTPase activating protein Git2 on metastasis in breast cancer].
Neoplasm Metastasis
[Effects of RAB1A on the proliferation, invasion, and metastasis of tongue squamous cell carcinoma cells].
Neoplasms
1'-Acetoxychavicol Acetate Suppresses Angiogenesis-Mediated Human Prostate Tumor Growth by Targeting VEGF-Mediated Src-FAK-Rho GTPase Signaling Pathway.
Neoplasms
11q13 allelic loss in pituitary tumors in patients with multiple endocrine neoplasia syndrome type 1.
Neoplasms
1H, 15N backbone assignment and comparative analysis of the wild type and G12C, G12D, G12V mutants of K-Ras bound to GDP at physiological pH.
Neoplasms
?3?1 integrins regulate CD151 complex assembly and membrane dynamics in carcinoma cells within 3D environments.
Neoplasms
A case report of tongue metastasis from lung squamous cell carcinoma and literature review.
Neoplasms
A diketopiperazine fragment of human serum albumin modulates T-lymphocyte cytokine production through rap1.
Neoplasms
A kinase-dependent role for EphA2 receptor in promoting tumor growth and metastasis.
Neoplasms
A novel mechanism by which tissue transglutaminase activates signaling events that promote cell survival.
Neoplasms
A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype.
Neoplasms
A pituitary specific point mutation of codon 201 of the Gs alpha gene in a pituitary adenoma of a patient with multiple endocrine neoplasia (MEN) type 1.
Neoplasms
A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination.
Neoplasms
A thirty-year quest for a role of R-Ras in cancer: from an oncogene to a multitasking GTPase.
Neoplasms
A transcriptional cross-talk between RhoA and c-Myc inhibits the RhoA/Rock-dependent cytoskeleton.
Neoplasms
Aberrant expression of Rab1A and its prognostic significance in human colorectal cancer.
Neoplasms
Aberrant methylation of the Ras-related associated with diabetes gene in human primary esophageal cancer.
Neoplasms
Ablation of Goalpha overrides G1 restriction point control through Ras/ERK/cyclin D1-CDK activities.
Neoplasms
Abnormal methylation of GRAF promoter Chinese patients with acute myeloid leukemia.
Neoplasms
Activated Galpha subunits can inhibit multiple signal transduction pathways during Dictyostelium development.
Neoplasms
Activating Gs alpha mutation at the Arg201 codon in liposclerosing myxofibrous tumor.
Neoplasms
Activating mutation in the stimulatory guanine nucleotide-binding protein in an infant with Cushing's syndrome and nodular adrenal hyperplasia.
Neoplasms
Activating mutation of the stimulatory G protein (gsp) as a putative cause of ovarian and testicular human stromal Leydig cell tumors.
Neoplasms
Activating mutations of the Gs alpha gene are associated with low levels of Gs alpha protein in growth hormone-secreting tumors.
Neoplasms
Activation of the Ran GTPase is subject to growth factor regulation and can give rise to cellular transformation.
Neoplasms
Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning.
Neoplasms
ADP-ribosylation factor 1 expression regulates epithelial-mesenchymal transition and predicts poor clinical outcome in triple-negative breast cancer.
Neoplasms
ALEX1, a novel tumor suppressor gene, inhibits gastric cancer metastasis via the PAR-1/Rho GTPase signaling pathway.
Neoplasms
Allosteric modulation of Ras and the PI3K/AKT/mTOR pathway: emerging therapeutic opportunities.
Neoplasms
Allosteric modulation of Ras-GTP is linked to signal transduction through RAF kinase.
Neoplasms
Alterations in guanine nucleotide regulatory protein expression and activity in human hepatocellular carcinoma.
Neoplasms
Amplified expression of p21 ras protein in hormone-dependent mammary carcinomas of humans and rodents.
Neoplasms
An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis.
Neoplasms
An immune escape screen reveals Cdc42 as regulator of cancer susceptibility to lymphocyte-mediated tumor suppression.
Neoplasms
An in vitro model of thyroid neoplasia: permanently transfected FRTL-5 cells with thyroglobulin promoter-cholera toxin A1 subunit minigene.
Neoplasms
Analysis of mutations in genes of the follicle-stimulating hormone receptor signaling pathway in ovarian granulosa cell tumors.
Neoplasms
Analysis of the Gs alpha gene in growth hormone-secreting pituitary adenomas by the polymerase chain reaction-direct sequencing method using paraffin-embedded tissues.
Neoplasms
Anticancer Activity of BIM-46174, a New Inhibitor of the Heterotrimeric G{alpha}/G{beta}{gamma} Protein Complex.
Neoplasms
Antimetastatic effects of gambogic acid are mediated via the actin cytoskeleton and NF-?B pathways in SK-HEP1 cells.
Neoplasms
Application of the antitussive agents oxelaidin and butamirate as anti-glioma agents.
Neoplasms
ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer.
Neoplasms
ARHGAP6 regulates the proliferation, migration and invasion of lung cancer cells.
Neoplasms
Association of elongation factor 2 with ribosomes during growth of a murine ascitic tumor.
Neoplasms
Association of Krev-1/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22.
Neoplasms
Association of somatotrophinomas with loss of alleles on chromosome 11 and with gsp mutations.
Neoplasms
Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice.
Neoplasms
Bioinformatics analysis of potential therapeutic targets among ARHGAP genes in breast cancer.
Neoplasms
C3G self-regulatory mechanism revealed: implications for hematopoietic malignancies.
Neoplasms
Cancer Cell Invasion in Three-dimensional Collagen Is Regulated Differentially by G?13 Protein and Discoidin Domain Receptor 1-Par3 Protein Signaling.
Neoplasms
Cancer-Associated Point Mutations in the DLC1 Tumor Suppressor and Other Rho-GAPs Occur Frequently and Are Associated with Decreased Function.
Neoplasms
CAPN1 is a novel binding partner and regulator of the tumor suppressor NF1 in melanoma.
Neoplasms
Catalytically Competent Non-transforming H-RASG12P Mutant Provides Insight into Molecular Switch Function and GAP-independent GTPase Activity of RAS.
Neoplasms
Caveolae as a target to quench autoinduction of the metastatic phenotype in lung cancer.
Neoplasms
cDNA structure, alternative splicing and exon-intron organization of the predisposing tuberous sclerosis (Tsc2) gene of the Eker rat model.
Neoplasms
Characterization of genomic alterations and the significance of PI3K/mTOR pathway mutations and tumor mutational burden in non?small cell lung cancer.
Neoplasms
Chemical reverse transformation of CHO-K1 cells induces changes in expression of a candidate tumour suppressor and of a gene not previously characterised as transformation related.
Neoplasms
Ciclosporin inhibits phorbol-ester-induced hyperplastic transformation and tumor promotion in mouse skin probably by suppression of Ca2+/calmodulin-dependent processes such as phosphorylation of elongation factor 2.
Neoplasms
Circadian locomotor output cycles kaput affects the proliferation and migration of breast cancer cells by regulating the expression of E-cadherin via IQ motif containing GTPase activating protein 1.
Neoplasms
CircRNA circUGGT2 Contributes to Hepatocellular Carcinoma Development via Regulation of the miR-526b-5p/RAB1A Axis.
Neoplasms
Clinical and Genetic Risk Factors for Perianal Crohn's Disease in a Population-Based Cohort.
Neoplasms
Clonal origin of toxic thyroid nodules with constitutively activating thyrotropin receptor mutations.
Neoplasms
Codon usage regulates human KRAS expression at both transcriptional and translational levels.
Neoplasms
Comparative transcriptional analysis reveals distinct expression patterns of channel catfish genes after the first infection and re-infection with Aeromonas hydrophila.
Neoplasms
Comparative Transcriptomics Analysis of Testicular miRNA from Cryptorchid and Normal Horses.
Neoplasms
Comparison of tissue-selective proinflammatory gene induction in mice infected with wild-type, DNA adenine methylase-deficient, and flagellin-deficient Salmonella enterica.
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Concomitant presence of JAK2V617F mutation and BCR?ABL translocation in two patients: A new entity or a variant of myeloproliferative neoplasms (Case report).
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Coordinated activation of the Rac-GAP ?2-chimaerin by an atypical proline-rich domain and diacylglycerol.
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Correlation of the Rac1/RhoA Pathway With Ezrin Expression in Osteosarcoma.
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CRMP5-associated GTPase (CRAG) Is a Candidate Driver Gene for Colorectal Cancer Carcinogenesis.
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Cushing's syndrome due to bilateral adrenocortical adenomas with different pathological features.
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Data Independent Acquisition Proteomic Analysis Can Discriminate between Actinic Keratosis, Bowen's Disease, and Cutaneous Squamous Cell Carcinoma.
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Death-associated protein kinase 1 suppresses hepatocellular carcinoma cell migration and invasion by upregulation of DEAD-box helicase 20.
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Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis.
Neoplasms
Decreased 8N3-[gamma-32P]GTP photolabeling of Gs alpha in tumorigenic lung epithelial cell lines: association with decreased hormone responsiveness and loss of contact-inhibited growth.
Neoplasms
Decreased GTPase activity of K-ras mutants deriving from human functional adrenocortical tumours.
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Decreased incorporation of the photoaffinity probe 8N3-[gamma-32P]-GTP into a 45kD protein in lung tumors.
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Detection of gsp oncogene in growth hormone-secreting pituitary adenomas and the study of clinical characteristics of acromegalic patients with gsp-positive pituitary tumors.
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Detection of label-free cancer biomarkers using nickel nanoislands and quartz crystal microbalance.
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Dichotomous roles of claudins as tumor promoters or suppressors: lessons from knockout mice.
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Differences in GTPase-activating protein activity between liver tumors and normal liver tissue in mice.
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DIRAS3-Derived Peptide Inhibits Autophagy in Ovarian Cancer Cells by Binding to Beclin1.
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Discovery of MINC1, a GTPase-Activating Protein Small Molecule Inhibitor, Targeting MgcRacGAP.
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Discrimination of low- and high-grade appendiceal mucinous neoplasms by targeted sequencing of cancer-related variants.
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Dissecting the roles of Ephrin-A3 in malignant peripheral nerve sheath tumor by TALENs.
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Distinct functional relevance of dynamic GTPase cysteine methylation in fission yeast.
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DLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathway.
Neoplasms
Dominant negative Rac1 attenuates paclitaxel-induced apoptosis in human melanoma cells through upregulation of heat shock protein 27: a functional proteomic analysis.
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Down-regulation of beta-adrenergic receptors by pindolol in Gs alpha-transfected S49 cyc- murine lymphoma cells.
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Downregualtion of dynamin-related protein 1 attenuates glutamate-induced excitotoxicity via regulating mitochondrial function in a calcium dependent manner in HT22 cells.
Neoplasms
Duplication of Glu37 in the switch I region of HRAS impairs effector/GAP binding and underlies Costello syndrome by promoting enhanced growth factor-dependent MAPK and AKT activation.
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Dynamin II function is required for EGF-mediated Stat3 activation but not Erk1/2 phosphorylation.
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Effect of tumor necrosis factor on GTP binding and GTPase activity in HL-60 and L929 cells.
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Effect of tumor promoting phorbol ester TPA on epidermal protein synthesis: stimulation of an elongation factor 2 phosphatase activity by TPA in vivo.
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EGF ligand fused to truncated Pseudomonas aeruginosa exotoxin A specifically targets and inhibits EGFR?positive cancer cells.
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Elevated expression of ECT2 predicts unfavorable prognosis in patients with colorectal cancer.
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Elongation factor 1 from ascites tumor cells: interaction with ribosomes and elongation factor 2.
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Emergence and scattering of multiple neurofibromatosis (NF1)-related sequences during hominoid evolution suggest a process of pericentromeric interchromosomal transposition.
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Emergence of the Dedifferentiated Phenotype in Hepatocyte-Derived Tumors in Mice: Roles of Oncogene-Induced Epigenetic Alterations.
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Endocrine manifestations of stimulatory G protein alpha-subunit mutations and the role of genomic imprinting.
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Endothelial Rab7 GTPase Mediates Tumor Growth and Metastasis in Lysosomal Acid Lipase Deficient Mice.
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ENO1 Acts as a Prognostic Biomarker Candidate and Promotes Tumor Growth and Migration Ability Through the Regulation of Rab1A in Colorectal Cancer.
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Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer.
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Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.
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ERK-dependent suicide gene therapy for selective targeting of RTK/RAS-driven cancers.
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Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth.
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Essential role of the cancer stem/progenitor cell marker nucleostemin for indole-3-carbinol anti-proliferative responsiveness in human breast cancer cells.
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Evaluation of active Rac1 levels in cancer cells: A case of misleading conclusions from immunofluorescence analysis.
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Evolutionarily conserved role of nucleostemin: controlling proliferation of stem/progenitor cells during early vertebrate development.
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Expression of CCT6A mRNA in chicken granulosa cells is regulated by progesterone.
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Expression of functional stimulatory guanine nucleotide binding protein in nonfunctioning thyroid adenomas is not correlated to adenylate cyclase activity and growth of these tumors.
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Expression of G protein alpha subunits in normal rat colon and in azoxymethane-induced colonic neoplasms.
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Expression of mutationally activated G alpha s stimulates growth and differentiation of thyroid FRTL5 cells.
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Expression of Rab1A is upregulated in human lung cancer and associated with tumor size and T stage.
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Expression of Rac-1 related to tumor depth, lymph node metastasis and patient prognosis in esophageal squamous cell carcinoma.
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Expression pattern of the PRDX2, RAB1A, RAB1B, RAB5A and RAB25 genes in normal and cancer cervical tissues.
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Expression, purification, and characterization of soluble K-Ras4B for structural analysis.
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Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies.
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FGFR1 is essential for N-acetyl-seryl-aspartyl-lysyl-proline regulation of mitochondrial dynamics by upregulating microRNA let-7b-5p.
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Fragile Histidine Triad Mediated Tumor Suppression of Lung Cancer by Targeting Multiple Components of the Ras/Rho GTPase Molecular Switch.
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Frequent Heterogeneous Missense Mutations of GGAP2 in Prostate Cancer: Implications for Tumor Biology, Clonality and Mutation Analysis.
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Functional expression of NF1 tumor suppressor protein: association with keratin intermediate filaments during the early development of human epidermis.
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G protein mutations in tumours of the pituitary, parathyroid and endocrine pancreas.
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G-protein alpha(olf) subunit promotes cellular invasion, survival, and neuroendocrine differentiation in digestive and urogenital epithelial cells.
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G?13-mediated LATS1 down-regulation contributes to epithelial-mesenchymal transition in ovarian cancer.
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G?s protein expression is an independent predictor of recurrence in prostate cancer.
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Gene trap mutagenesis-based forward genetic approach reveals that the tumor suppressor OVCA1 is a component of the biosynthetic pathway of diphthamide on elongation factor 2.
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Genomic profile - a possible diagnostic and prognostic marker in upper tract urothelial carcinoma.
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Genomic sequence analysis of a key residue (Arg183) in human G alpha q in invasive non-functional pituitary adenomas.
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Glycoprotein hormone alpha-subunit production in somatotroph adenomas with and without Gs alpha mutations.
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GNAS1 (G?s) Gene T393C Polymorphism and Renal Cell Carcinoma Risk in a North Indian Population: A Case-Control Study.
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GNG2 inhibits invasion of human malignant melanoma cells with decreased FAK activity.
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GPER Activation Inhibits Cancer Cell Mechanotransduction and Basement Membrane Invasion via RhoA.
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Growth factors regulate cell survival by controlling nutrient transporter expression.
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Growth hormone-prolactin-thyrotropin-secreting pituitary adenoma in atypical McCune-Albright syndrome with functionally normal Gs alpha protein.
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Gs alpha mutation may be uncommon in patients with multiple endocrine neoplasia type 1.
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Gs alpha overexpression and loss of Gs alpha imprinting in human somatotroph adenomas: association with tumor size and response to pharmacologic treatment.
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Gs alpha--identification of a gene highly expressed by insulinoma and other endocrine tumors.
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GTPase regulator associated with the focal adhesion kinase (GRAF) transcript was down-regulated in patients with myeloid malignancies.
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Guanine nucleotide-binding protein subunit beta-4 promotes gastric cancer progression via activating Erk1/2.
Neoplasms
Guanylate-binding protein-2 inhibits colorectal cancer cell growth and increases the sensitivity to paclitaxel of paclitaxel-resistant colorectal cancer cells by interfering Wnt signaling.
Neoplasms
Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes.
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Heterotrimeric G protein signaling in cancer cells with regard to metastasis formation.
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Heterotrimeric G-protein alpha-12 (G?12) subunit promotes oral cancer metastasis.
Neoplasms
High expression of IQGAP3 indicates poor prognosis in colorectal cancer patients.
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High salinity induced expression profiling of differentially expressed genes in shrimp (Penaeus monodon).
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Higher levels of dynamin-related protein 1 are associated with reduced radiation sensitivity of glioblastoma cells.
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HRAS as a potential therapeutic target of salirasib RAS inhibitor in bladder cancer.
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Hsc70 contributes to cancer cell survival by preventing Rab1A degradation under stress conditions.
Neoplasms
Human breast cancer MDA-MB-231 cells fail to express the neurofibromin protein, lack its type I mRNA isoform and show accumulation of P-MAPK and activated Ras.
Neoplasms
Hypoxia-mediated miR-212-3p downregulation enhances progression of intrahepatic cholangiocarcinoma through upregulation of Rab1a.
Neoplasms
Identification of a mutation in the gene encoding the alpha subunit of the stimulatory G protein of adenylyl cyclase in McCune-Albright syndrome.
Neoplasms
Identification of an autoinhibitory mechanism that restricts C1 domain-mediated activation of the Rac-GAP alpha2-chimaerin.
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Identification of G protein alpha subunit mutations in human growth hormone (GH)- and GH/prolactin-secreting pituitary tumors by single-strand conformation polymorphism (SSCP) analysis.
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Identification of genes differentially expressed between benign and osteopontin transformed rat mammary epithelial cells.
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Identification of heat shock protein 90 and other proteins as tumour antigens by serological screening of an ovarian carcinoma expression library.
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Identification of novel dynamin-related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia-reperfusion injury.
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IFNg-induced Irgm1 promotes tumorigenesis of melanoma via dual regulation of apoptosis and Bif-1-dependent autophagy.
Neoplasms
Immunodetection of G proteins in human pituitary adenomas: evidence for a low expression of proteins of the Gi subfamily.
Neoplasms
Impact of Cadmium on Intracellular Zinc Levels in HepG2 Cells: Quantitative Evaluations and Molecular Effects.
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Impact of combined mTOR and MEK inhibition in uveal melanoma is driven by tumor genotype.
Neoplasms
Increased Ras GTPase activity is regulated by miRNAs that can be attenuated by CDF treatment in pancreatic cancer cells.
Neoplasms
Induction of human microsomal prostaglandin E synthase 1 by activated oncogene RhoA GTPase in A549 human epithelial cancer cells.
Neoplasms
Inhibition of endothelial cell proliferation by targeting Rac1 GTPase with small interference RNA in tumor cells.
Neoplasms
Inhibition of RAB1A suppresses epithelial-mesenchymal transition and proliferation of triple-negative breast cancer cells.
Neoplasms
Inhibition of the RhoA GTPase Activity Increases Sensitivity of Melanoma Cells to UV Radiation Effects.
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Integrated Analysis of the Clinical and Molecular Characteristics of IDH Wild-Type Gliomas in the Chinese Glioma Genome Atlas.
Neoplasms
Integration of multiple signaling pathway activities resolves K-RAS/N-RAS mutation paradox in colon epithelial cell response to inflammatory cytokine stimulation.
Neoplasms
Integration of quantitative phosphoproteomics and transcriptomics revealed phosphorylation-mediated molecular events as useful tools for a potential patient stratification and personalized treatment of human nonfunctional pituitary adenomas.
Neoplasms
Interaction of an adenovirus 14.7-kilodalton protein inhibitor of tumor necrosis factor alpha cytolysis with a new member of the GTPase superfamily of signal transducers.
Neoplasms
Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation.
Neoplasms
Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42.
Neoplasms
Investigating the role of ADP-ribosylation factor 6 in tumor cell invasion and extracellular signal-regulated kinase activation.
Neoplasms
Investigation of GTP-dependent dimerization of G12X K-Ras variants using ultraviolet photodissociation mass spectrometry.
Neoplasms
IQGAP1 suppresses T?RII-mediated myofibroblastic activation and metastatic growth in liver.
Neoplasms
IQGAP1?siRNA inhibits proliferation and metastasis of U251 and U373 glioma cell lines.
Neoplasms
IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL.
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IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells.
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IQGAP2 is a novel interferon-alpha antiviral effector gene acting non-conventionally through the NF-?B pathway.
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IQGAP3 Overexpression Correlates With Poor Prognosis and Radiation Therapy Resistance in Breast Cancer.
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IQGAP3 promotes cancer proliferation and metastasis in high-grade serous ovarian cancer.
Neoplasms
Irgm1 knockout indirectly inhibits regeneration after skeletal muscle injury in mice.
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Is current therapy of malignant gliomas beneficial for patients? Proteomics evidence of shifts in glioma cells expression patterns under clinically relevant treatment conditions.
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K-Ras G-domain binding with signaling lipid Phosphatidyl inositol (4,5) phosphate (PIP2): Membrane association, protein orientation and function.
Neoplasms
Kalopanaxsaponin a inhibits the invasion of human oral squamous cell carcinoma by reducing metalloproteinase-9 mRNA stability and protein trafficking.
Neoplasms
Kisspeptin-10, a KISS1-derived decapeptide, inhibits tumor angiogenesis by suppressing Sp1-mediated VEGF expression and FAK/Rho GTPase activation.
Neoplasms
Knockdown of RAP2A gene expression suppresses cisplatin resistance in gastric cancer cells.
Neoplasms
KRas4B-PDE6? complex stabilization by small molecules obtained by virtual screening affects Ras signaling in pancreatic cancer.
Neoplasms
KRASG12C inhibition produces a driver-limited state revealing collateral dependencies.
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Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic disease.
Neoplasms
Linear free energy relationships in the intrinsic and GTPase activating protein-stimulated guanosine 5'-triphosphate hydrolysis of p21ras.
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Long Noncoding RNA MNX1 antisense RNA 1 Exerts Oncogenic Functions in Bladder Cancer by Regulating miR-218-5p/RAB1A Axis.
Neoplasms
Long-acting peptidomimergic control of gigantism caused by pituitary acidophilic stem cell adenoma.
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Loss of MIEF1/MiD51 confers susceptibility to BAX-mediated cell death and PINK1-PRKN-dependent mitophagy.
Neoplasms
Low prevalence of Gs alpha mutations in Åomatotroph adenomas of children and adolescents.
Neoplasms
Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines.
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Lymphoid blast transformation in an MPN with BCR-JAK2 treated with ruxolitinib: putative mechanisms of resistance.
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Macrophage contact induces RhoA GTPase signaling to trigger tumor cell intravasation.
Neoplasms
Mammosomatotroph adenoma causing gigantism in an 8-year old boy: a possible pathogenetic mechanism.
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Maspin controls mammary tumor cell migration through inhibiting Rac1 and Cdc42, but not the RhoA GTPase.
Neoplasms
Mass spectroscopic phosphoprotein mapping of Ral binding protein 1 (RalBP1/Rip1/RLIP76).
Neoplasms
Mechanistic Insights into the Differential Catalysis by RheB and Its Mutants: Y35A and Y35A-D65A.
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Met-Gly-Cys motif from G-protein alpha subunit cannot direct palmitoylation when fused to heterologous protein.
Neoplasms
Metastasis Suppressors NME1 and NME2 Promote Dynamin 2 Oligomerization and Regulate Tumor Cell Endocytosis, Motility, and Metastasis.
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Methylation and gene silencing of the Ras-related GTPase gene in lung and breast cancers.
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MIB1 upregulates IQGAP1 and promotes pancreatic cancer progression by inducing ST7 degradation.
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MicroRNA-19b Promotes Nasopharyngeal Carcinoma More Sensitive to Cisplatin by Suppressing KRAS.
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MicroRNA-Based Therapeutic Strategies for Targeting Mutant and Wild Type RAS in Cancer.
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MicroRNA?4500 suppresses tumor progression in non?small cell lung cancer by regulating STAT3.
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miR-15b-5p induces endoplasmic reticulum stress and apoptosis in human hepatocellular carcinoma, both in vitro and in vivo, by suppressing Rab1A.
Neoplasms
MiR-655-3p inhibited proliferation and migration of ovarian cancer cells by targeting RAB1A.
Neoplasms
miR?139?3p suppresses the invasion and migration properties of breast cancer cells by targeting RAB1A.
Neoplasms
Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in inflammatory breast cancer.
Neoplasms
Modulation of RhoA GTPase Activity Sensitizes Human Cervix Carcinoma Cells to ?-Radiation by Attenuating DNA Repair Pathways.
Neoplasms
Molecular aspects of the pathogenesis of nodular goiters, thyroid nodules and adenomas.
Neoplasms
Molecular epidemiologic features of inflammatory breast cancer: a comparison between Egyptian and US patients.
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Molecular mechanisms of platelet activation and aggregation induced by breast cancer cells.
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Molecular mutation characteristics of mismatch and homologous recombination repair genes in gastrointestinal cancer.
Neoplasms
Morelloflavone, a biflavonoid, inhibits tumor angiogenesis by targeting rho GTPases and extracellular signal-regulated kinase signaling pathways.
Neoplasms
mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1.
Neoplasms
Multiplexed Real-Time NMR GTPase Assay for Simultaneous Monitoring of Multiple Guanine Nucleotide Exchange Factor Activities from Human Cancer Cells and Organoids.
Neoplasms
Neoplastic reprogramming of patient-derived adipose stem cells by prostate cancer cell-associated exosomes.
Neoplasms
Neurofibromatosis 1 gene (NF1) mutation is a rare genetic event in myelodysplastic syndrome regardless of the disease progression.
Neoplasms
Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration-implications for increased neurofibroma formation during pregnancy.
Neoplasms
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Neoplasms
Next-generation sequencing identified somatic alterations that may underlie the etiology of Chinese papillary thyroid carcinoma.
Neoplasms
NF1 inactivation cooperates with N-ras in in vivo lymphogenesis activating Erk by a mechanism independent of its Ras-GTPase accelerating activity.
Neoplasms
No evidence for oncogenic mutations in guanine nucleotide-binding proteins of human adrenocortical neoplasms.
Neoplasms
Nonsense mutations in the C-terminal SH2 region of the GTPase activating protein (GAP) gene in human tumours.
Neoplasms
Novel transmembrane GTPase of non-small cell lung cancer identified by mRNA differential display.
Neoplasms
Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance.
Neoplasms
Oncogenic K-Ras Regulates Bioactive Sphingolipids in a Sphingosine Kinase 1-dependent Manner.
Neoplasms
Oncogenic mutations of alpha-Gi2 protein are not determinant for human adrenocortical tumourigenesis.
Neoplasms
Over-Expression of TBL1XR1 Indicates Poor Prognosis of Serous Epithelial Ovarian Cancer.
Neoplasms
Overexpression and translocation of dynamin 2 promotes tumor aggressiveness in breast carcinomas.
Neoplasms
Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer.
Neoplasms
Overexpression of Gs alpha subunit in thyroid tumors bearing a mutated Gs alpha gene.
Neoplasms
Overexpression of IQGAP1 promotes the angiogenesis of esophageal squamous cell carcinoma through the AKT and ERK?mediated VEGF?VEGFR2 signaling pathway.
Neoplasms
Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster.
Neoplasms
Overexpression of MTH1 and OGG1 proteins in ulcerative colitis-associated carcinogenesis.
Neoplasms
Overexpression of optic atrophy 1 protein increases cisplatin resistance via inactivation of caspase-dependent apoptosis in lung adenocarcinoma cells.
Neoplasms
Overexpression of Ran GTPase Components Regulating Nuclear Export, but not Mitotic Spindle Assembly, Marks Chromosome Instability and Poor Prognosis in Breast Cancer.
Neoplasms
Overexpression of the regulator of G-protein signaling 5 reduces the survival rate and enhances the radiation response of human lung cancer cells.
Neoplasms
p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities.
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p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas.
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P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance.
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Pancreatic cancer: modulation of KRAS, MicroRNAs, and intercellular communication in the setting of tumor heterogeneity.
Neoplasms
Parathyroid-targeted overexpression of Regulator of G-Protein Signaling 5 (R GS5) causes hyperparathyroidism in transgenic mice.
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Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
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Ph(-) myeloproliferative neoplasm red blood cells display deregulation of IQGAP1-Rho GTPase signaling depending on CALR/JAK2 status.
Neoplasms
Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings.
Neoplasms
Phosphorylation of FADD by the kinase CK1? promotes KRASG12D-induced lung cancer.
Neoplasms
Phosphorylation of merlin regulates its stability and tumor suppressive activity.
Neoplasms
PKA phosphorylation and 14-3-3 interaction regulate the function of neurofibromatosis type I tumor suppressor, neurofibromin.
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Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells.
Neoplasms
Plexin B1 is repressed by oncogenic B-Raf signaling and functions as a tumor suppressor in melanoma cells.
Neoplasms
Pooled analysis of prognostic value and clinical significance of Rab1A expression in human solid tumors.
Neoplasms
Potent transforming activity of the G13 alpha subunit defines a novel family of oncogenes.
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Presence of a Gs alpha mutation in an adrenal tumor expressing LH/hCG receptors and clinically associated with Cushing's syndrome.
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Prevalences of Gs alpha, ras, p53 mutations and ret/PTC rearrangement in differentiated thyroid tumours in a Korean population.
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PREX2 promotes the proliferation, invasion and migration of pancreatic cancer cells by modulating the PI3K signaling pathway.
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Prognosis Significance and Positive Correlation of Rab1A and p-S6K/Gli1 Expression in Gastric Cancer.
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Promoter hypermethylation of Ras-related GTPase gene RRAD inactivates a tumor suppressor function in nasopharyngeal carcinoma.
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Pronostic and therapeutic consequences of Gs alpha mutations in somatotroph adenomas.
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Proteomic analysis reveals hyperactivation of the mammalian target of rapamycin pathway in neurofibromatosis 1-associated human and mouse brain tumors.
Neoplasms
Rab1A knockdown represses proliferation and promotes apoptosis in gastric cancer cells by inhibition of mTOR/p70S6K pathway.
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Rab1A promotes cancer metastasis and radioresistance through activating GSK-3?/Wnt/?-catenin signaling in nasopharyngeal carcinoma.
Neoplasms
Rab1A promotes cell proliferation and migration by upregulating Gli1 in colorectal cancer.
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Rab1A promotes proliferation and migration abilities via regulation of the HER2/AKT-independent mTOR/S6K1 pathway in colorectal cancer.
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Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments.
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Rab35 GTPase: A Central Regulator of Phosphoinositides and F-actin in Endocytic Recycling and Beyond.
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RAB38 Facilitates Energy Metabolism and Counteracts Cell Death in Glioblastoma Cells.
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Rab7 GTPase controls lipid metabolic signaling in myeloid-derived suppressor cells.
Neoplasms
RAC1 plays an essential role in estrogen receptor alpha function in breast cancer cells.
Neoplasms
Rac1-mediated sustained ?4 integrin level develops reattachment ability of breast cancer cells after anchorage loss.
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Rac2 controls tumor growth, metastasis and M1-M2 macrophage differentiation in vivo.
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Rag GTPases suppress PRL-3 degradation and predict poor clinical diagnosis of cancer patients with low PRL-3 mRNA expression.
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Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion.
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Ran GTPase is an independent prognostic marker in malignant melanoma which promotes tumour cell migration and invasion.
Neoplasms
Ran GTPase promotes cancer progression via Met recepto-rmediated downstream signaling.
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Ran-binding protein 3 is associated with human spermatogenesis and male infertility.
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Rap1 activity is elevated in malignant astrocytomas independent of tuberous sclerosis complex-2 gene expression.
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Rap1 GTPase Inhibits Tumor Necrosis Factor-?-Induced Choroidal Endothelial Migration via NADPH Oxidase- and NF-?B-Dependent Activation of Rac1.
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RAP1 GTPase overexpression is associated with cervical intraepithelial neoplasia.
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Rapid Somatic Mutation Testing in Colorectal Cancer by Use of a Fully Automated System and Single-Use Cartridge: A Comparison with Next-Generation Sequencing.
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Rare mutations of the Gs alpha subunit gene in human endocrine tumors. Mutation detection by polymerase chain reaction-primer-introduced restriction analysis.
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Ras Homolog Family Member F, Filopodia Associated Promotes Hepatocellular Carcinoma Metastasis by Altering the Metabolic Status of Cancer Cells Through RAB3D.
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Ras mutational status is a biomarker for resistance to EGFR inhibitors in colorectal carcinoma.
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Ras stabilization through aberrant activation of Wnt/?-catenin signaling promotes intestinal tumorigenesis.
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Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
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Ras-induced epigenetic inactivation of Ras-related associated with diabetes gene (RRAD) promotes glucose uptake in a human ovarian cancer model.
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RAS-MEK independent gene expression reveals BMP2-related malignant phenotypes in the Nf1-deficient MPNST.
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RAS-related GTPases DIRAS1 and DIRAS2 induce autophagic cancer cell death and are required for autophagy in murine ovarian cancer cells.
Neoplasms
RASAL2 down-regulation in ovarian cancer promotes epithelial-mesenchymal transition and metastasis.
Neoplasms
Recombinant human thrombopoietin combined with interleukin-2 improves the effects of chemosensitivity and thrombocytopenia on a basic gemcitabine and carboplatin combination therapy for non-small cell lung cancer in a nude mouse model.
Neoplasms
Reduced constitutive 8-oxoguanine-DNA glycosylase expression and impaired induction following oxidative DNA damage in the tuberin deficient Eker rat.
Neoplasms
Regulation of pancreatic cancer cell migration and invasion by RhoC GTPase and caveolin-1.
Neoplasms
Reverse pharmacophore mapping and molecular docking studies for discovery of GTPase HRas as promising drug target for bis-pyrimidine derivatives.
Neoplasms
RhoA modulates functional and physical interaction between ROCK1 and Erk1/2 in selenite-induced apoptosis of leukaemia cells.
Neoplasms
RhoA protein expression correlates positively with degree of malignancy in astrocytomas.
Neoplasms
RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells.
Neoplasms
RhoA/ROCK pathway inhibition by fasudil suppresses the vasculogenic mimicry of U2OS osteosarcoma cells in vitro.
Neoplasms
RhoC GTPase overexpression modulates induction of angiogenic factors in breast cells.
Neoplasms
RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype.
Neoplasms
RhoC induces differential expression of genes involved in invasion and metastasis in MCF10A breast cells.
Neoplasms
RhoGDI2 expression is associated with tumor growth and malignant progression of gastric cancer.
Neoplasms
RIN1 promotes renal cell carcinoma malignancy by activating EGFR signaling through Rab25.
Neoplasms
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Neoplasms
ROCK1 and ROCK2 are Required for Non-Small Cell Lung Cancer Anchorage-Independent Growth and Invasion.
Neoplasms
ROCK2 mediates osteosarcoma progression and TRAIL resistance by modulating O-GlcNAc transferase degradation.
Neoplasms
Role of IQGAP3 in metastasis and epithelial-mesenchymal transition in human hepatocellular carcinoma.
Neoplasms
Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells.
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RRAD inhibits aerobic glycolysis, invasion, and migration and is associated with poor prognosis in hepatocellular carcinoma.
Neoplasms
Sarcoid-Like Granulomatous Disease: Pathologic Case Series in World Trade Center Dust Exposed Rescue and Recovery Workers.
Neoplasms
Screening of candidate oncogenes in human thyrotroph tumors: absence of activating mutations of the G alpha q, G alpha 11, G alpha s, or thyrotropin-releasing hormone receptor genes.
Neoplasms
Screening of mutations in the additional sex combs like 1, transcriptional regulator, tumor protein p53, and KRAS proto-oncogene, GTPase/NRAS proto-oncogene, GTPase genes of patients with myelodysplastic syndrome.
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Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis.
Neoplasms
Selective Oral MEK1/2 Inhibitor Pimasertib in Metastatic Melanoma: Antitumor Activity in a Phase I, Dose-Escalation Trial.
Neoplasms
Semaphorin 4D expression is associated with a poor clinical outcome in cervical cancer patients.
Neoplasms
Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors).
Neoplasms
Significance and prognostic role of human epidermal growth factor receptor 2 and RAB1A expression in gastric cancer.
Neoplasms
Significance of Thr182 in the nucleotide-exchange and GTP-hydrolysis reactions of the alpha subunit of GTP-binding protein Gi2.
Neoplasms
Significantly increased cortisol secretion in normal adrenocortical cells transfected with K-ras mutants derived from human functional adrenocortical tumors.
Neoplasms
SIPA1 enhances SMAD2/3 expression to maintain stem cell features in breast cancer cells.
Neoplasms
Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.
Neoplasms
Small guanosine triphosphatase Rho/Rho-associated kinase as a novel regulator of intracellular redistribution of lysosomes in invasive tumor cells.
Neoplasms
Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth.
Neoplasms
Specific repression of mutant K-RAS by 10-23 DNAzyme: sensitizing cancer cell to anti-cancer therapies.
Neoplasms
Sporadic cardiac myxomas and tumors from patients with Carney complex are not associated with activating mutations of the Gs alpha gene.
Neoplasms
Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.
Neoplasms
Structural studies of the thyrotropin receptor and Gs alpha in human thyroid cancers: low prevalence of mutations predicts infrequent involvement in malignant transformation.
Neoplasms
Structure of the BH domain from graf and its implications for Rho GTPase recognition.
Neoplasms
Study of the multiple endocrine neoplasia type 1, growth hormone-releasing hormone receptor, Gs alpha, and Gi2 alpha genes in isolated familial acromegaly.
Neoplasms
Suppression of the proliferation and migration of oncogenic ras-dependent cell lines, cultured in a three-dimensional collagen matrix, by flavonoid-structured molecules.
Neoplasms
Suppression of Tobacco Carcinogen-Induced Lung Tumorigenesis by Aerosol-Delivered Glycerol Propoxylate Triacrylate-Spermine Copolymer/Short Hairpin Rab25 RNA Complexes in Female A/J Mice.
Neoplasms
Swiprosin-1 stimulates cancer invasion and metastasis by increasing the Rho family of GTPase signaling.
Neoplasms
TBL1XR1 as a potential therapeutic target that promotes epithelial-mesenchymal transition in lung squamous cell carcinoma.
Neoplasms
TBL1XR1 induces cell proliferation and inhibit cell apoptosis by the PI3K/AKT pathway in pancreatic ductal adenocarcinoma.
Neoplasms
The GTPase and Rho GAP domains of p190, a tumor suppressor protein that binds the M(r) 120,000 Ras GAP, independently function as anti-Ras tumor suppressors.
Neoplasms
The GTPase KRAS suppresses the p53 tumor suppressor by activating the NRF2-regulated antioxidant defense system in cancer cells.
Neoplasms
The GTPase Ran: regulation of cell life and potential roles in cell transformation.
Neoplasms
The interferon-gamma-induced GTPase, mGBP-2, inhibits tumor necrosis factor alpha (TNF-alpha) induction of matrix metalloproteinase-9 (MMP-9) by inhibiting NF-kappaB and Rac protein.
Neoplasms
The lncRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b/c and let-7b.
Neoplasms
The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion.
Neoplasms
The peptide recognized by HLA-A68.2-restricted, squamous cell carcinoma of the lung-specific cytotoxic T lymphocytes is derived from a mutated elongation factor 2 gene.
Neoplasms
The prohibitin-binding compound fluorizoline affects multiple components of the translational machinery and inhibits protein synthesis.
Neoplasms
The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells.
Neoplasms
The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model.
Neoplasms
The Rac3 GTPase in Neuronal Development, Neurodevelopmental Disorders, and Cancer.
Neoplasms
The RAS-interacting chaperone UNC119 drives the RASSF6-MDM2-p53 axis and antagonizes RAS-mediated malignant transformation.
Neoplasms
The Regulatory Mechanisms of Dynamin-Related Protein 1 in Tumor Development and Therapy.
Neoplasms
The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells.
Neoplasms
The role of vascular endothelial growth factor, interleukin 8, and insulinlike growth factor in sustaining autophagic DIRAS3-induced dormant ovarian cancer xenografts.
Neoplasms
The small GTP-binding protein Rho links G protein-coupled receptors and Galpha12 to the serum response element and to cellular transformation.
Neoplasms
The Small Molecule BC-2059 Inhibits Wingless/Integrated (Wnt)-Dependent Gene Transcription in Cancer through Disruption of the Transducin ?-Like 1-?-Catenin Protein Complex.
Neoplasms
The thyrotropin receptor (TSH-R) is not an oncogene for thyroid tumors: structural studies of the TSH-R and the alpha-subunit of Gs in human thyroid neoplasms.
Neoplasms
The transcription factor GLI1 modulates the inflammatory response during pancreatic tissue remodeling.
Neoplasms
The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho.
Neoplasms
The tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) provokes a prolonged morphologic response and ERK activation in Tsc2-null renal tumor cells.
Neoplasms
The tumour promoter okadaic acid inhibits reticulocyte-lysate protein synthesis by increasing the net phosphorylation of elongation factor 2.
Neoplasms
The UPR Transducer IRE1 Promotes Breast Cancer Malignancy by Degrading Tumor Suppressor microRNAs.
Neoplasms
The WW domain of the scaffolding protein IQGAP1 is neither necessary nor sufficient for binding to the MAPKs ERK1 and ERK2.
Neoplasms
Transamidase site-targeted agents alter the conformation of the transglutaminase cancer stem cell survival protein to reduce GTP binding activity and cancer stem cell survival.
Neoplasms
Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth.
Neoplasms
Transcriptional alterations of genes related to fertility decline in male rats induced by chronic sleep restriction.
Neoplasms
Transcriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy.
Neoplasms
Transducin (?)-like 1 X-linked receptor 1 correlates with clinical prognosis and clinicopathological characteristics in human solid carcinomas.
Neoplasms
Transducin (Beta)-Like 1 X-Linked Receptor 1 Correlates with Clinical Prognosis and Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma.
Neoplasms
Transducin ?-like 1 X-linked receptor 1 suppresses cisplatin sensitivity in nasopharyngeal carcinoma via activation of NF-?B pathway.
Neoplasms
Transformation to small cell lung cancer and activation of KRAS during long-term erlotinib maintenance in a patient with non-small cell lung cancer: A case report.
Neoplasms
Transglutaminase 2 promotes tumorigenicity of colon cancer cells by inactivation of the tumor suppressor p53.
Neoplasms
TSH receptor and Gs-alpha gene mutations in the pathogenesis of toxic thyroid adenomas--a note of caution.
Neoplasms
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioblastoma cell chemotaxis via Lyn activation.
Neoplasms
Tumor vasculature is a key determinant for the efficiency of nanoparticle-mediated siRNA delivery.
Neoplasms
Two different pituitary adenomas in a patient with multiple endocrine neoplasia type 1 associated with growth hormone-releasing hormone-producing pancreatic tumor: clinical and genetic features.
Neoplasms
Upregulation of LINC00659 expression predicts a poor prognosis and promotes migration and invasion of gastric cancer cells.
Neoplasms
Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42.
Neoplasms
When RASSF1A RAN into tumor suppression: Ran GTPase is a RASSF1A effector involved in controlling microtubule organization.
Neoplasms
WISP3 and RhoC guanosine triphosphatase cooperate in the development of inflammatory breast cancer.
Neoplasms
Zoledronic acid inhibits TSC2-null cell tumor growth via RhoA/YAP signaling pathway in mouse models of lymphangioleiomyomatosis.
Neoplasms
[Heterogeneity of GTPase-activating proteins for Ras in the regulation of Ras signal transduction pathway]
Nervous System Diseases
GTPase Regulator Associated with Focal Adhesion Kinase 1 (GRAF1) Immunoglobulin-Associated Ataxia and Neuropathy.
Nervous System Diseases
Optic Atrophy 1 Controls Human Neuronal Development by Preventing Aberrant Nuclear DNA Methylation.
Nervous System Diseases
The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1.
Neuralgia
Distinct roles of srGAP3-Rac1 in the initiation and maintenance phases of neuropathic pain induced by paclitaxel.
Neuralgia
Inhibition of Mitochondrial Fission Protein Reduced Mechanical Allodynia and Suppressed Spinal Mitochondrial Superoxide Induced by Perineural Human Immunodeficiency Virus gp120 in Rats.
Neuralgia
Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain.
Neurilemmoma
Actin-rich protrusions and nonlocalized GTPase activation in Merlin-deficient schwannomas.
Neurilemmoma
Identification of recurrent regions of chromosome loss and gain in vestibular schwannomas using comparative genomic hybridisation.
Neuroacanthocytosis
Genomic organization of the human galpha14 and Galphaq genes and mutation analysis in chorea-acanthocytosis (CHAC).
Neuroblastoma
Activation of pertussis toxin-sensitive G-proteins in membranes of SH-SY5Y human neuroblastoma cells and bovine transducin by ethanol.
Neuroblastoma
Alterations in the expression of G-proteins and regulation of adenylate cyclase in human neuroblastoma SH-SY5Y cells chronically exposed to low-efficacy mu-opioids.
Neuroblastoma
Altered membrane NTPase activity in Lesch-Nyhan disease fibroblasts: comparison with HPRT knockout mice and HPRT-deficient cell lines.
Neuroblastoma
Antibodies which recognize the C-terminus of the inhibitory guanine-nucleotide-binding protein (Gi) demonstrate that opioid peptides and foetal-calf serum stimulate the high-affinity GTPase activity of two separate pertussis-toxin substrates.
Neuroblastoma
Bradykinin stimulates GTP hydrolysis in NG108-15 membranes by a high-affinity, pertussis toxin-insensitive GTPase.
Neuroblastoma
Changing expression of GTPase activating proteins with differentiation in neuroblastoma.
Neuroblastoma
Cholera toxin impairment of opioid-mediated inhibition of adenylate cyclase in neuroblastoma x glioma hybrid cells is due to a toxin-induced decrease in opioid receptor levels.
Neuroblastoma
Delta-opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein Gi2.
Neuroblastoma
Desensitization of D1 dopamine receptors down-regulates the Gs alpha subunit of G protein in SK-N-MC neuroblastoma cells.
Neuroblastoma
Desensitization of opioid-stimulated GTPase in neuroblastoma x glioma hybrid cells.
Neuroblastoma
Differential effects of suramin on the coupling of receptors to individual species of pertussis-toxin-sensitive guanine-nucleotide-binding proteins.
Neuroblastoma
Effect of retinoic acid on p21ras and regulators of its activity in neuroblastoma.
Neuroblastoma
Effects of beta-endorphin on mu and delta opioid receptor-coupled G-protein activity: low-Km GTPase studies.
Neuroblastoma
Epac- and Ca2+ -controlled activation of Ras and extracellular signal-regulated kinases by Gs-coupled receptors.
Neuroblastoma
Equivalent regulation of wild type and an epitope-tagged variant of Gs alpha by the IP prostanoid receptor following expression in neuroblastoma x glioma hybrid, NG108-15, cells.
Neuroblastoma
Estrogen induces neurite outgrowth via Rho family GTPases in neuroblastoma cells.
Neuroblastoma
Genome wide transcriptomic analysis identifies pathways affected by the infusion of Clostridium perfringens culture supernatant in the duodenum of broilers in situ.
Neuroblastoma
Identification of a rapidly dephosphorylating 95-kDa protein as elongation factor 2 during 8-Br-cAMP treatment of N1E115 neuroblastoma cells.
Neuroblastoma
Identification of the critical domains of the delta-opioid receptor involved in G protein coupling using site-specific synthetic peptides.
Neuroblastoma
Inhibition of ADP-ribosyltransferase increases synthesis of Gs alpha in neuroblastoma x glioma hybrid cells and reverses iloprost-dependent heterologous loss of fluoride-sensitive adenylate cyclase.
Neuroblastoma
Interaction between optineurin and Rab1a regulates autophagosome formation in neuroblastoma cells.
Neuroblastoma
Modulation of sodium-sensitive GTPase by partial opiate agonists. An explanation for the dual requirement for Na+ and GTP in inhibitory regulation of adenylate cyclase.
Neuroblastoma
Novel bimodal effects of the G-protein tissue transglutaminase on adrenoreceptor signalling.
Neuroblastoma
Prostaglandin E1-mediated, cyclic AMP-independent, down-regulation of Gs alpha in neuroblastoma x glioma hybrid cells.
Neuroblastoma
Quantitative stoichiometry of the proteins of the stimulatory arm of the adenylyl cyclase cascade in neuroblastoma x glioma hybrid, NG108-15 cells.
Neuroblastoma
Regulation of cellular Gs alpha levels and basal adenylyl cyclase activity by expression of the beta 2-adrenoceptor in neuroblastoma cell lines.
Neuroblastoma
Retinoic acid-induced differentiation of human neuroblastoma SH-SY5Y cells is associated with changes in the abundance of G proteins.
Neuroblastoma
Selective activation of Galphao by D2L dopamine receptors in NS20Y neuroblastoma cells.
Neuroblastoma
Thrombin stimulates pertussis toxin-sensitive and -insensitive GTPase activities and ADP-ribosylation of G(i) in human neuroblastoma SH-EP.
Neuroblastoma
Vasoactive intestinal peptide-induced neurite remodeling in human neuroblastoma SH-SY5Y cells implicates the Cdc42 GTPase and is independent of Ras-ERK pathway.
Neurocutaneous Syndromes
Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis.
Neurodegenerative Diseases
Diverse roles of Rho family GTPases in neuronal development, survival, and death.
Neurodegenerative Diseases
Downregualtion of dynamin-related protein 1 attenuates glutamate-induced excitotoxicity via regulating mitochondrial function in a calcium dependent manner in HT22 cells.
Neurodegenerative Diseases
Elevated stimulatory and reduced inhibitory G protein alpha subunits in cerebellar cortex of patients with dominantly inherited olivopontocerebellar atrophy.
Neurodegenerative Diseases
Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E2 receptor EP2 subtype.
Neurodegenerative Diseases
The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.
Neurodegenerative Diseases
Ulk1 Governs Nerve Growth Factor/TrkA Signaling by Mediating Rab5 GTPase Activation in Porcine Hemagglutinating Encephalomyelitis Virus-Induced Neurodegenerative Disorders.
Neuroectodermal Tumors, Primitive
RABL6A Promotes Pancreatic Neuroendocrine Tumor Angiogenesis and Progression In Vivo.
Neurofibroma
Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration-implications for increased neurofibroma formation during pregnancy.
Neurofibromatoses
A functional assay for heterozygous mutations in the GTPase activating protein related domain of the neurofibromatosis type 1 gene.
Neurofibromatoses
Analysis of mutations and expression of GAP-related domain of the neurofibromatosis type 1 (NF1) gene in the progression of chronic myelogenous leukemia.
Neurofibromatoses
Antibody against neurofibromatosis type 1 gene product reacts with a triton-insoluble GTPase activating protein toward ras p21.
Neurofibromatoses
Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice.
Neurofibromatoses
Brain tumors predominantly express the neurofibromatosis type 1 gene transcripts containing the 63 base insert in the region coding for GTPase activating protein-related domain.
Neurofibromatoses
Differences in GTPase-activating protein activity between liver tumors and normal liver tissue in mice.
Neurofibromatoses
Differential regulation of rasGAP and neurofibromatosis gene product activities.
Neurofibromatoses
Differential splicing of the neurofibromatosis type-1 gene in the rat - splice variants homologous with the human are expressed in rat-cells.
Neurofibromatoses
Emergence and scattering of multiple neurofibromatosis (NF1)-related sequences during hominoid evolution suggest a process of pericentromeric interchromosomal transposition.
Neurofibromatoses
Enriched expression of NF1 in inhibitory neurons in both mouse and human brain.
Neurofibromatoses
Expression of the GTPase activating domain of the neurofibromatosis type 1 (NF1) gene in Escherichia coli and role of the conserved lysine residue.
Neurofibromatoses
Genetic and functional studies implicate synaptic overgrowth and ring gland cAMP/PKA signaling defects in the Drosophila melanogaster neurofibromatosis-1 growth deficiency.
Neurofibromatoses
Heterogeneous amino acids in Ras and Rap1A specifying sensitivity to GAP proteins.
Neurofibromatoses
Inhibition of Ras/Raf interaction by anti-oncogenic mutants of neurofibromin, the neurofibromatosis type 1 (NF1) gene product, in cell-free systems.
Neurofibromatoses
Neurofibromatosis Type 1 Alternative Splicing is a Key Regulator of Ras Signaling in Neurons.
Neurofibromatoses
Neurofibromatosis: The role of guanosine triphosphatase activating proteins in sensory neuron function.
Neurofibromatoses
Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration-implications for increased neurofibroma formation during pregnancy.
Neurofibromatoses
Nf1 Regulates Alcohol Dependence-Associated Excessive Drinking and Gamma-Aminobutyric Acid Release in the Central Amygdala in Mice and Is Associated with Alcohol Dependence in Humans.
Neurofibromatoses
PKA phosphorylation and 14-3-3 interaction regulate the function of neurofibromatosis type I tumor suppressor, neurofibromin.
Neurofibromatoses
Regulation of Ras-GAP and the neurofibromatosis-1 gene product by eicosanoids.
Neurofibromatoses
Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells.
Neurofibromatoses
The GTPase stimulatory activities of the neurofibromatosis type 1 and the yeast IRA2 proteins are inhibited by arachidonic acid.
Neurofibromatoses
The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1.
Neurofibromatosis 1
A functional assay for heterozygous mutations in the GTPase activating protein related domain of the neurofibromatosis type 1 gene.
Neurofibromatosis 1
A neurofibromatosis-1-regulated pathway is required for learning in Drosophila.
Neurofibromatosis 1
Analysis of mutations and expression of GAP-related domain of the neurofibromatosis type 1 (NF1) gene in the progression of chronic myelogenous leukemia.
Neurofibromatosis 1
Antibody against neurofibromatosis type 1 gene product reacts with a triton-insoluble GTPase activating protein toward ras p21.
Neurofibromatosis 1
Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice.
Neurofibromatosis 1
Brain tumors predominantly express the neurofibromatosis type 1 gene transcripts containing the 63 base insert in the region coding for GTPase activating protein-related domain.
Neurofibromatosis 1
Differences in GTPase-activating protein activity between liver tumors and normal liver tissue in mice.
Neurofibromatosis 1
Differential splicing of the neurofibromatosis type-1 gene in the rat - splice variants homologous with the human are expressed in rat-cells.
Neurofibromatosis 1
Effector domain mutations dissociate p21ras effector function and GTPase-activating protein interaction.
Neurofibromatosis 1
Emergence and scattering of multiple neurofibromatosis (NF1)-related sequences during hominoid evolution suggest a process of pericentromeric interchromosomal transposition.
Neurofibromatosis 1
Enriched expression of NF1 in inhibitory neurons in both mouse and human brain.
Neurofibromatosis 1
Expression of the GTPase activating domain of the neurofibromatosis type 1 (NF1) gene in Escherichia coli and role of the conserved lysine residue.
Neurofibromatosis 1
Genetic and functional studies implicate synaptic overgrowth and ring gland cAMP/PKA signaling defects in the Drosophila melanogaster neurofibromatosis-1 growth deficiency.
Neurofibromatosis 1
Heterogeneous amino acids in Ras and Rap1A specifying sensitivity to GAP proteins.
Neurofibromatosis 1
Inhibition of Ras/Raf interaction by anti-oncogenic mutants of neurofibromin, the neurofibromatosis type 1 (NF1) gene product, in cell-free systems.
Neurofibromatosis 1
Mutations in the GAP-related domain impair the ability of neurofibromin to associate with microtubules.
Neurofibromatosis 1
Neurofibromatosis 1 gene (NF1) mutation is a rare genetic event in myelodysplastic syndrome regardless of the disease progression.
Neurofibromatosis 1
Neurofibromatosis Type 1 Alternative Splicing is a Key Regulator of Ras Signaling in Neurons.
Neurofibromatosis 1
Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration-implications for increased neurofibroma formation during pregnancy.
Neurofibromatosis 1
Nf1 Regulates Alcohol Dependence-Associated Excessive Drinking and Gamma-Aminobutyric Acid Release in the Central Amygdala in Mice and Is Associated with Alcohol Dependence in Humans.
Neurofibromatosis 1
PKA phosphorylation and 14-3-3 interaction regulate the function of neurofibromatosis type I tumor suppressor, neurofibromin.
Neurofibromatosis 1
Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells.
Neurofibromatosis 1
The GTPase stimulatory activities of the neurofibromatosis type 1 and the yeast IRA2 proteins are inhibited by arachidonic acid.
Neurofibromatosis 1
The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1.
Neuroinflammatory Diseases
G2019s LRRK2 promotes mitochondrial fission and increases TNF?-mediated neuroinflammation responses.
Neurologic Manifestations
CID1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neurologic deficits and inhibits reactive astrogliosis in rat ischemic stroke.
Neutropenia
Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia.
Neutropenia
Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.
Niemann-Pick Disease, Type C
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Niemann-Pick Diseases
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Night Blindness
A truncated form of rod photoreceptor PDE6 ?-subunit causes autosomal dominant congenital stationary night blindness by interfering with the inhibitory activity of the ?-subunit.
Night Blindness
Autoantibodies to transducin in a patient with melanoma-associated retinopathy.
Night Blindness
Coexistence of GNAT1 and ABCA4 variants associated with Nougaret-type congenital stationary night blindness and childhood-onset cone-rod dystrophy.
Night Blindness
Loss of the effector function in a transducin-alpha mutant associated with Nougaret night blindness.
Night Blindness
Missense mutation in the gene encoding the alpha subunit of rod transducin in the Nougaret form of congenital stationary night blindness.
Night Blindness
Molecular genetics of Oguchi disease, fundus albipunctatus, and other forms of stationary night blindness: LVII Edward Jackson Memorial Lecture.
Night Blindness
Molecular interactions and mutational impact upon rhodopsin (G90?D90) for hindering dark adaptation of eye: A comparative structural level outlook for signaling mechanism in night blindness.
Night Blindness
Network and atomistic simulations unveil the structural determinants of mutations linked to retinal diseases.
Non-alcoholic Fatty Liver Disease
The immunity-related GTPase M rs13361189 variant does not increase the risk for prevalent or incident steatosis; results from the Framingham Heart Study.
Non-alcoholic Fatty Liver Disease
Variants in the autophagy-related gene IRGM confer susceptibility to non-alcoholic fatty liver disease by modulating lipophagy.
Noonan Syndrome
M-Ras/Shoc2 signaling modulates E-cadherin turnover and cell-cell adhesion during collective cell migration.
Obesity
Adiponectin Signaling and Impaired GTPase Rab5 Expression in Adipocytes of Adolescents with Obesity.
Obesity
Association of fat mass and obesity-associated and retinitis pigmentosa guanosine triphosphatase (GTPase) regulator-interacting protein-1 like polymorphisms with body mass index in Chinese women.
Obesity
Genome-wide analysis identifies colonic genes differentially associated with serum leptin and insulin concentrations in C57BL/6J mice fed a high-fat diet.
Obesity
Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice.
Obesity
Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level.
Obesity
Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha-subunit (Gsalpha) knockout mice is due to tissue-specific imprinting of the gsalpha gene.
Ocular Hypertension
Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E2 receptor EP2 subtype.
Ocular Hypertension
RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork.
Oculocerebrorenal Syndrome
Guanine nucleotide exchange factors activate Rab8a for Toll-like receptor signalling.
Oculocerebrorenal Syndrome
Rab35 GTPase and OCRL phosphatase remodel lipids and F-actin for successful cytokinesis.
Oculocerebrorenal Syndrome
Rab35 GTPase Triggers Switch-like Recruitment of the Lowe Syndrome Lipid Phosphatase OCRL on Newborn Endosomes.
Olfaction Disorders
The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia.
Optic Atrophy
De novo missense variant in the GTPase effector domain (GED) of DNM1L leads to static encephalopathy and seizures.
Optic Atrophy
Elevated hydrostatic pressure triggers release of OPA1 and cytochrome C, and induces apoptotic cell death in differentiated RGC-5 cells.
Optic Atrophy, Autosomal Dominant
A Mitofusin-2-dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver.
Optic Atrophy, Autosomal Dominant
Elevated hydrostatic pressure triggers release of OPA1 and cytochrome C, and induces apoptotic cell death in differentiated RGC-5 cells.
Optic Atrophy, Autosomal Dominant
Mitochondrial oxidative phosphorylation in autosomal dominant optic atrophy.
Optic Atrophy, Autosomal Dominant
Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin.
Optic Atrophy, Autosomal Dominant
Mutation spectrum and splicing variants in the OPA1 gene.
Optic Atrophy, Autosomal Dominant
OPA1 loss of function affects in vitro neuronal maturation.
Optic Atrophy, Autosomal Dominant
OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L.
Optic Atrophy, Autosomal Dominant
Opa1 Reduces Hypoxia-Induced Cardiomyocyte Death by Improving Mitochondrial Quality Control.
Optic Atrophy, Autosomal Dominant
OPA1-associated disorders: Phenotypes and pathophysiology.
Optic Atrophy, Autosomal Dominant
OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand.
Optic Atrophy, Autosomal Dominant
Optic Atrophy 1 Controls Human Neuronal Development by Preventing Aberrant Nuclear DNA Methylation.
Optic Atrophy, Autosomal Dominant
Optimized OPA1 Isoforms 1 and 7 Provide Therapeutic Benefit in Models of Mitochondrial Dysfunction.
Optic Atrophy, Autosomal Dominant
Overexpression of optic atrophy 1 protein increases cisplatin resistance via inactivation of caspase-dependent apoptosis in lung adenocarcinoma cells.
Optic Atrophy, Autosomal Dominant
Structural model of the OPA1 GTPase domain may explain the molecular consequences of a novel mutation in a family with autosomal dominant optic atrophy.
Optic Atrophy, Autosomal Dominant
The mitochondrial inner membrane GTPase, Optic Atrophy 1 (Opa1), restores mitochondrial morphology and promotes neuronal survival following excitotoxicity.
Optic Atrophy, Autosomal Dominant
The mitochondrial permeability transition regulates cytochrome c release for apoptosis during endoplasmic reticulum stress by remodeling the cristae junction.
Ornithine Carbamoyltransferase Deficiency Disease
Identification of a cytogenetic deletion and of four novel mutations (Q69X, I172F, G188V, G197R) affecting the gene for ornithine transcarbamylase (OTC) in Spanish patients with OTC deficiency.
Ornithine Carbamoyltransferase Deficiency Disease
Symptoms of OTC deficiency but not DMD in a female carrier of an Xp21.1 deletion including the genes for dystrophin and OTC.
Osteoma
Reduction in Gsalpha induces osteogenic differentiation in human mesenchymal stem cells.
Osteoporosis
Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E2 receptor EP2 subtype.
Osteosarcoma
A Simplified System for Evaluating Cell Mechanosensing and Durotaxis In Vitro.
Osteosarcoma
Identification of potential gene targets in systemic vasculitis using DNA microarray analysis.
Osteosarcoma
RBEL1 is required for osteosarcoma cell proliferation via inhibiting retinoblastoma 1.
Osteosarcoma
RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation.
Osteosarcoma
ROCK2 mediates osteosarcoma progression and TRAIL resistance by modulating O-GlcNAc transferase degradation.
Osteosarcoma
The Focal Adhesion-Localized CdGAP Regulates Matrix Rigidity Sensing and Durotaxis.
Ovarian Cysts
Recurrent ovarian cyst and mutation of the Gs alpha gene in ovarian cyst fluid cells: what is the link with McCune-Albright syndrome?
Ovarian Neoplasms
A Novel Pharmacologic Activity of Ketorolac for Therapeutic Benefit in Ovarian Cancer Patients.
Ovarian Neoplasms
An essential role for Ran GTPase in epithelial ovarian cancer cell survival.
Ovarian Neoplasms
An mDia2/ROCK signaling axis regulates invasive egress from epithelial ovarian cancer spheroids.
Ovarian Neoplasms
MiR-655-3p inhibited proliferation and migration of ovarian cancer cells by targeting RAB1A.
Ovarian Neoplasms
Ran promotes membrane targeting and stabilization of RhoA to orchestrate ovarian cancer cell invasion.
Ovarian Neoplasms
The role of vascular endothelial growth factor, interleukin 8, and insulinlike growth factor in sustaining autophagic DIRAS3-induced dormant ovarian cancer xenografts.
Pancreatic Neoplasms
Allosteric modulation of Ras and the PI3K/AKT/mTOR pathway: emerging therapeutic opportunities.
Pancreatic Neoplasms
ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer.
Pancreatic Neoplasms
BART inhibits pancreatic cancer cell invasion by PKC? inactivation through binding to ANX7.
Pancreatic Neoplasms
BART inhibits pancreatic cancer cell invasion by Rac1 inactivation through direct binding to active Rac1.
Pancreatic Neoplasms
Detection of KRAS Mutations in Circulating Tumor DNA by Digital PCR in Early Stages of Pancreatic Cancer.
Pancreatic Neoplasms
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer.
Pancreatic Neoplasms
Increased Ras GTPase activity is regulated by miRNAs that can be attenuated by CDF treatment in pancreatic cancer cells.
Pancreatic Neoplasms
Multiple mechanisms involved in a low concentration of FL118 enhancement of AMR-MeOAc to induce pancreatic cancer cell apoptosis and growth inhibition.
Pancreatic Neoplasms
Mutant K-RAS Promotes Invasion and Metastasis in Pancreatic Cancer Through GTPase Signaling Pathways.
Pancreatic Neoplasms
Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice.
Pancreatic Neoplasms
Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer.
Pancreatic Neoplasms
Pancreatic cancer: modulation of KRAS, MicroRNAs, and intercellular communication in the setting of tumor heterogeneity.
Pancreatic Neoplasms
Pro-migratory and TGF-?-activating functions of ?v?6 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switch.
Pancreatic Neoplasms
Ran GTPase protein promotes human pancreatic cancer proliferation by deregulating the expression of Survivin and cell cycle proteins.
Pancreatic Neoplasms
Ran GTPase protein promotes metastasis and invasion in pancreatic cancer by deregulating the expression of AR and CXCR4.
Pancreatic Neoplasms
Regulation of pancreatic cancer cell migration and invasion by RhoC GTPase and caveolin-1.
Pancreatic Neoplasms
Transcriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy.
Papilloma
The neurofibromatosis type 1 (Nf1) tumor suppressor is a modifier of carcinogen-induced pigmentation and papilloma formation in C57BL/6 mice.
Paralysis
Autonomously functioning thyroid nodule associated with thyrotoxic periodic paralysis.
Paralysis
Developmental stage- and tissue-specific expression of shibire, a Drosophila gene involved in endocytosis.
Paralysis
Structural characterization of ribosome recruitment and translocation by type IV IRES.
Paramyxoviridae Infections
Emerging views of mitophagy in immunity and autoimmune diseases.
Paraneoplastic Syndromes, Ocular
Autoantibodies to transducin in a patient with melanoma-associated retinopathy.
Paraneoplastic Syndromes, Ocular
Cancer-retina antigens as potential paraneoplastic antigens in melanoma-associated retinopathy.
Parathyroid Neoplasms
Absence of mutations in the Gs alpha and Gi2 alpha genes in sporadic parathyroid adenomas and insulinomas.
Parathyroid Neoplasms
Gs alpha--identification of a gene highly expressed by insulinoma and other endocrine tumors.
Parkinson Disease
Allosteric Inhibition of Parkinson's-Linked LRRK2 by Constrained Peptides.
Parkinson Disease
Allosteric modulation of the GTPase activity of a bacterial LRRK2 homologue by conformation-specific Nanobodies.
Parkinson Disease
Alternative mitochondrial quality control mediated by extracellular release.
Parkinson Disease
Andrographolide alleviates parkinsonism in MPTP-PD mice via targeting DRP1-mediated mitochondrial fission.
Parkinson Disease
ARHGEF7 (BETA-PIX) Acts as Guanine Nucleotide Exchange Factor for Leucine-Rich Repeat Kinase 2.
Parkinson Disease
Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modifies Kinase and GTP-Binding Activities.
Parkinson Disease
Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers.
Parkinson Disease
Elevated TYROBP expression predicts poor prognosis and high tumor immune infiltration in patients with low-grade glioma.
Parkinson Disease
Kinetic, mechanistic, and structural modeling studies of truncated wild-type leucine-rich repeat kinase 2 and the G2019S mutant.
Parkinson Disease
Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants.
Parkinson Disease
LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function.
Parkinson Disease
LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding.
Parkinson Disease
LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate.
Parkinson Disease
LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease.
Parkinson Disease
mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1.
Parkinson Disease
Phosphorylation of LRRK2 by casein kinase 1? regulates trans-Golgi clustering via differential interaction with ARHGEF7.
Parkinson Disease
Rab1A Over-Expression Prevents Golgi Apparatus Fragmentation and Partially Corrects Motor Deficits in an Alpha-Synuclein Based Rat Model of Parkinson's Disease.
Parkinson Disease
S-Nitrosylation of DRP1 does not affect enzymatic activity and is not specific to Alzheimer's disease.
Parkinson Disease
Supersensitization of neurochemical responses by L-DOPA and dopamine receptor agonists in the striatum of experimental Parkinson's disease model rats.
Parkinson Disease
The dual enzyme LRRK2 hydrolyzes GTP in both its GTPase and kinase domains in vitro.
Parkinson Disease
The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites.
Parkinson Disease
The Role of LRRK2 in the Regulation of Monocyte Adhesion to Endothelial Cells.
Parkinson Disease
X Caps the Phosphate for Phospho-Rab GTPase Recognition in Ciliogenesis and Parkinson's Disease.
Pediatric Obesity
Adiponectin Signaling and Impaired GTPase Rab5 Expression in Adipocytes of Adolescents with Obesity.
Pemphigus
Beyond steric hindrance: the role of adhesion signaling pathways in the pathogenesis of pemphigus.
Peripheral Nervous System Diseases
A cohort study of MFN2 mutations and phenotypic spectrums in Charcot-Marie-Tooth disease 2A patients.
Peripheral Nervous System Diseases
Alterations of autophagy in the peripheral neuropathy Charcot-Marie-Tooth type 2B.
Peripheral Nervous System Diseases
Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin.
Peripheral Nervous System Diseases
Rab7 mutants associated with Charcot-Marie-Tooth disease cause delayed growth factor receptor transport and altered endosomal and nuclear signaling.
Peripheral Nervous System Diseases
Rab7 mutants associated with Charcot-Marie-Tooth disease exhibit enhanced NGF-stimulated signaling.
Periventricular Nodular Heterotopia
Role of a heterotrimeric G-protein, Gi2, in the corticogenesis: possible involvement in periventricular nodular heterotopia and intellectual disability.
Peroxisomal Disorders
Peroxisomal disease cell lines with cellular plasmalogen deficiency have impaired muscarinic cholinergic signal transduction activity and amyloid precursor protein secretion.
Pheochromocytoma
Cardioprotective effect of histamine H3-receptor activation: pivotal role of G beta gamma-dependent inhibition of voltage-operated Ca2+ channels.
Pheochromocytoma
Cytosolic Cl- Affects the Anticancer Activity of Paclitaxel in the Gastric Cancer Cell Line, MKN28 Cell.
Pheochromocytoma
Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade.
Pheochromocytoma
Evidence of the presence of GTPase inhibiting proteins for a low M(r) GTP-binding protein, ram p25, in rat spleen and pheochromocytoma PC12 cells.
Pheochromocytoma
Gs alpha--identification of a gene highly expressed by insulinoma and other endocrine tumors.
Pheochromocytoma
Induction of neurite extension and survival in pheochromocytoma cells by the Rit GTPase.
Pheochromocytoma
miR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signalling.
Pheochromocytoma
Pituitary adenylate cyclase-activating polypeptide 38-mediated Rin activation requires Src and contributes to the regulation of HSP27 signaling during neuronal differentiation.
Pheochromocytoma
Rare mutations of the Gs alpha subunit gene in human endocrine tumors. Mutation detection by polymerase chain reaction-primer-introduced restriction analysis.
Pheochromocytoma
Relatively good prognosis of multiple endocrine neoplasia type 2B in Japanese: review of cases in Japan and analysis of genetic changes in tumors.
Pheochromocytoma
The influence of nerve growth factor on the activities of adenylate cyclase and high-affinity GTPase in pheochromocytoma PC12 cell.
Pheochromocytoma
The neuronal monoamine transporter VMAT2 is regulated by the trimeric GTPase Go(2).
Pheochromocytoma
The novel GTPase Rit differentially regulates axonal and dendritic growth.
Photophobia
Excised patches of plasma membrane from vertebrate rod outer segments retain a functional phototransduction enzymatic cascade.
Photophobia
Rethinking the role of phosducin: light-regulated binding of phosducin to 14-3-3 in rod inner segments.
Photophobia
The Heterotrimeric G-protein Complex Modulates Light Sensitivity in Arabidopsis thaliana Seed Germination.
Picornaviridae Infections
Linking Virus Discovery to Immune Responses Visualized during Zebrafish Infections.
Pituitary Neoplasms
A new constitutively activating mutation of the Gs protein alpha subunit-gsp oncogene is found in human pituitary tumours.
Pituitary Neoplasms
A pituitary specific point mutation of codon 201 of the Gs alpha gene in a pituitary adenoma of a patient with multiple endocrine neoplasia (MEN) type 1.
Pituitary Neoplasms
Activating mutations of the Gs alpha gene are associated with low levels of Gs alpha protein in growth hormone-secreting tumors.
Pituitary Neoplasms
Activating mutations of the stimulatory G protein in the McCune-Albright syndrome.
Pituitary Neoplasms
Analysis of the Gs alpha gene in growth hormone-secreting pituitary adenomas by the polymerase chain reaction-direct sequencing method using paraffin-embedded tissues.
Pituitary Neoplasms
Clinical and biochemical characteristics of acromegalic patients harboring gsp-positive and gsp-negative pituitary tumors.
Pituitary Neoplasms
Constitutively active Gs alpha is associated with an increased phosphodiesterase activity in human growth hormone-secreting adenomas.
Pituitary Neoplasms
Detection of gsp oncogene in growth hormone-secreting pituitary adenomas and the study of clinical characteristics of acromegalic patients with gsp-positive pituitary tumors.
Pituitary Neoplasms
Estrogen- and xenoestrogen-induced ERK signaling in pituitary tumor cells involves estrogen receptor-? interactions with G protein-?i and caveolin I.
Pituitary Neoplasms
G protein Gs alpha (GNAS 1), the probable candidate gene for Albright hereditary osteodystrophy, is assigned to human chromosome 20q12-q13.2.
Pituitary Neoplasms
Genomic sequence analysis of a key residue (Arg183) in human G alpha q in invasive non-functional pituitary adenomas.
Pituitary Neoplasms
Ghrelin mRNA and GH secretagogue receptor mRNA in human GH-producing pituitary adenomas is affected by mutations in the alpha subunit of G protein.
Pituitary Neoplasms
Glycoprotein hormone alpha-subunit production in somatotroph adenomas with and without Gs alpha mutations.
Pituitary Neoplasms
Growth hormone-prolactin-thyrotropin-secreting pituitary adenoma in atypical McCune-Albright syndrome with functionally normal Gs alpha protein.
Pituitary Neoplasms
Gs alpha and Gi2 alpha mutations in clinically non-functioning pituitary tumours.
Pituitary Neoplasms
Gs alpha mutation at codon 201 in pituitary adenoma causing gigantism in a 6-year-old boy with McCune-Albright syndrome.
Pituitary Neoplasms
GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours.
Pituitary Neoplasms
Hydrolysis of GTP by the alpha-chain of Gs and other GTP binding proteins.
Pituitary Neoplasms
Identification of a mutation in the gene encoding the alpha subunit of the stimulatory G protein of adenylyl cyclase in McCune-Albright syndrome.
Pituitary Neoplasms
Identification of G protein alpha subunit mutations in human growth hormone (GH)- and GH/prolactin-secreting pituitary tumors by single-strand conformation polymorphism (SSCP) analysis.
Pituitary Neoplasms
Long-acting peptidomimergic control of gigantism caused by pituitary acidophilic stem cell adenoma.
Pituitary Neoplasms
Markers of function and proliferation in non-invasive and invasive bi- and plurihormonal adenomas of patients with acromegaly: an immunohistochemical study.
Pituitary Neoplasms
Molecular biology of growth-hormone-secreting human pituitary tumours: biochemical consequences and potential clinical significance.
Pituitary Neoplasms
Prevalence of Gs alpha mutations in Korean patients with pituitary adenomas.
Pituitary Neoplasms
Rare mutations of the Gs alpha subunit gene in human endocrine tumors. Mutation detection by polymerase chain reaction-primer-introduced restriction analysis.
Pituitary Neoplasms
Transcriptional effects in GH3 cells of Gs alpha mutants associated with human pituitary tumors: stimulation of adenosine 3',5'-monophosphate response element-binding protein-mediated transcription and of prolactin and growth hormone promoter activity via protein kinase A.
Pneumonia
Divergent Evolution of Legionella RCC1 Repeat Effectors Defines the Range of Ran GTPase Cycle Targets.
Polycystic Kidney Diseases
Activator of G protein signaling 3 promotes epithelial cell proliferation in PKD.
Polycystic Kidney Diseases
Heterotrimeric G protein signaling in polycystic kidney disease.
Polycystic Kidney, Autosomal Dominant
ADPKD: a human disease altering Golgi function and basolateral exocytosis in renal epithelia.
Polycystic Ovary Syndrome
Colocalization of Polycystic Ovary Syndrome Candidate Gene Products in Theca Cells Suggests Novel Signaling Pathways.
Polyneuropathies
The Charcot-Marie Tooth Disease Mutation R94Q in MFN2 Decreases ATP Production but Increases Mitochondrial Respiration under Conditions of Mild Oxidative Stress.
Porcine Reproductive and Respiratory Syndrome
Viral strategies for triggering and manipulating mitophagy.
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Forming megakaryocytes from murine-induced pluripotent stem cells by the inducible overexpression of supporting factors.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Bcr/Abl P190 interaction with Spa-1, a GTPase activating protein for the small GTPase Rap1.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Immunotoxins in cancer therapy: Review and update.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling.
Prolactinoma
Alteration of G alpha subunits mRNA levels in bromocriptine resistant prolactinomas.
Prostatic Neoplasms
A Rac1/Cdc42 GTPase-Specific Small Molecule Inhibitor Suppresses Growth of Primary Human Prostate Cancer Xenografts and Prolongs Survival in Mice.
Prostatic Neoplasms
CHC1-L, a candidate gene for prostate carcinogenesis at 13q14.2, is frequently affected by loss of heterozygosity and underexpressed in human prostate cancer.
Prostatic Neoplasms
Frequent Heterogeneous Missense Mutations of GGAP2 in Prostate Cancer: Implications for Tumor Biology, Clonality and Mutation Analysis.
Prostatic Neoplasms
Individual rac GTPases mediate aspects of prostate cancer cell and bone marrow endothelial cell interactions.
Prostatic Neoplasms
Inhibition of the GTPase Rac1 Mediates the Antimigratory Effects of Metformin in Prostate Cancer Cells.
Prostatic Neoplasms
Ligand-independent activation of androgen receptors by Rho GTPase signaling in prostate cancer.
Prostatic Neoplasms
MiR-221 promotes the development of androgen independence in prostate cancer cells via downregulation of HECTD2 and RAB1A.
Prostatic Neoplasms
Rho GTPases in PC-3 prostate cancer cell morphology, invasion and tumor cell diapedesis.
Prostatic Neoplasms
RhoC GTPase is required for PC-3 prostate cancer cell invasion but not motility.
Prostatic Neoplasms
SEC-induced activation of ANXA7 GTPase suppresses prostate cancer metastasis.
Prostatic Neoplasms
Small Molecule Inhibitors Targeting G?i2 Protein Attenuate Migration of Cancer Cells.
Prostatic Neoplasms
TBLR1 as an androgen receptor (AR) coactivator selectively activates AR target genes to inhibit prostate cancer growth.
Prostatic Neoplasms
The Arf-like GTPase Arl8b is essential for three-dimensional invasive growth of prostate cancer in vitro and xenograft formation and growth in vivo.
Prostatic Neoplasms
Type I collagen receptor (alpha2beta1) signaling promotes prostate cancer invasion through RhoC GTPase.
Protein Deficiency
G protein Gs alpha (GNAS 1), the probable candidate gene for Albright hereditary osteodystrophy, is assigned to human chromosome 20q12-q13.2.
Protein Deficiency
Olfactory dysfunction in type I pseudohypoparathyroidism: dissociation from Gs alpha protein deficiency.
Pseudarthrosis
Hyperactive Ras/MAPK signaling is critical for tibial nonunion fracture in neurofibromin-deficient mice.
Pseudohypoparathyroidism
A 4-base pair deletion mutation of Gs alpha gene in a Japanese patient with pseudohypoparathyroidism.
Pseudohypoparathyroidism
A deletion hot-spot in exon 7 of the Gs alpha gene (GNAS1) in patients with Albright hereditary osteodystrophy.
Pseudohypoparathyroidism
A heterozygous 4-bp deletion mutation in the Gs alpha gene (GNAS1) in a patient with Albright hereditary osteodystrophy.
Pseudohypoparathyroidism
A new heterozygous mutation (D196N) in the Gs alpha gene as a cause for pseudohypoparathyroidism type IA in a boy who had gallstones.
Pseudohypoparathyroidism
A novel Gs alpha mutant in a patient with Albright hereditary osteodystrophy uncouples cell surface receptors from adenylyl cyclase.
Pseudohypoparathyroidism
Characterization of a de novo 43-bp deletion of the Gs alpha gene (GNAS1) in Albright hereditary osteodystrophy.
Pseudohypoparathyroidism
Deficient erythrocyte membrane Gs alpha activity and resistance to trophic hormones of multiple endocrine organs in two cases of pseudohypoparathyroidism.
Pseudohypoparathyroidism
Distinct patterns of abnormal GNAS imprinting in familial and sporadic pseudohypoparathyroidism type IB.
Pseudohypoparathyroidism
G protein Gs alpha (GNAS 1), the probable candidate gene for Albright hereditary osteodystrophy, is assigned to human chromosome 20q12-q13.2.
Pseudohypoparathyroidism
Growth hormone-releasing hormone resistance in pseudohypoparathyroidism type ia: new evidence for imprinting of the Gs alpha gene.
Pseudohypoparathyroidism
Identification of two novel deletion mutations within the Gs alpha gene (GNAS1) in Albright hereditary osteodystrophy.
Pseudohypoparathyroidism
Intracranial calcification and brachydactyly mimicking Albright's hereditary osteodystrophy in an adult patient with lingual thyroid and prolactinoma-like lesion.
Pseudohypoparathyroidism
Molecular characterization of a cryptic 2q37 deletion in a patient with Albright hereditary osteodystrophy-like phenotype.
Pseudohypoparathyroidism
Mutations in exon 7 of the GTP-binding protein Gs alpha were not a common cause of pseudohypoparathyroidism with Albright's hereditary osteodystrophy in Japanese.
Pseudohypoparathyroidism
Olfactory dysfunction in type I pseudohypoparathyroidism: dissociation from Gs alpha protein deficiency.
Pseudohypoparathyroidism
Parental origin of Gs alpha gene mutations in Albright's hereditary osteodystrophy.
Pseudohypoparathyroidism
Prevalence of three mutations in the Gs alpha gene among 24 families with pseudohypoparathyroidism type Ia.
Pseudohypoparathyroidism
Pseudohypoparathyroidism type Ia: two new heterozygous frameshift mutations in exons 5 and 10 of the Gs alpha gene.
Pseudohypoparathyroidism
Skeletal abnormalities and extra-skeletal ossification in mice with restricted Gsalpha deletion caused by a renin promoter-Cre transgene.
Pseudohypoparathyroidism
The stimulatory G protein alpha-subunit Gs alpha is imprinted in human thyroid glands: implications for thyroid function in pseudohypoparathyroidism types 1A and 1B.
Pseudohypoparathyroidism
Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha-subunit (Gsalpha) knockout mice is due to tissue-specific imprinting of the gsalpha gene.
Pseudohypoparathyroidism
[G-proteins, their role in the transduction of the hormonal message and their pathology]
Pseudohypoparathyroidism
[Late onset epilepsy as the first symptom of pseudohypoparathyroidism]
Pseudopseudohypoparathyroidism
Immunochemical analysis of the alpha-subunit of the stimulatory G-protein of adenylyl cyclase in patients with Albright's hereditary osteodystrophy.
Pseudopseudohypoparathyroidism
Intracranial calcification and brachydactyly mimicking Albright's hereditary osteodystrophy in an adult patient with lingual thyroid and prolactinoma-like lesion.
Psoriasis
Role of Galphaq in pathogenesis of psoriasis, a new mechanism about the immune regulation in psoriasis.
Puberty, Precocious
Pubertal development in patients with McCune-Albright syndrome or pseudohypoparathyroidism.
Pulmonary Arterial Hypertension
Deletion of STAT5a/b in vascular smooth muscle abrogates the male bias in hypoxic pulmonary hypertension in mice: implications in the human disease.
Pulmonary Disease, Chronic Obstructive
HSP90AA1, ADRB2, TBL1XR1 and HSPB1 are chronic obstructive pulmonary disease-related genes that facilitate squamous cell lung cancer progression.
Pulmonary Disease, Chronic Obstructive
Pharmacological actions of statins: potential utility in COPD.
Q Fever
The Type IV Secretion System Effector Protein CirA Stimulates the GTPase Activity of RhoA and Is Required for Virulence in a Mouse Model of Coxiella burnetii Infection.
Rabies
Inhibition of opiate receptor-mediated signal transmission by rabies virus in persistently infected NG-108-15 mouse neuroblastoma-rat glioma hybrid cells.
Rabies
Interferon-Inducible GTPase 1 Impedes the Dimerization of Rabies Virus Phosphoprotein and Restricts Viral Replication.
Rabies
Interferon-inducible GTPase: a novel viral response protein involved in rabies virus infection.
Reperfusion Injury
Identification of novel dynamin-related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia-reperfusion injury.
Reperfusion Injury
Protection of cardiomyocytes from the hypoxia-mediated injury by a Peptide targeting the activator of g-protein signaling 8.
Reperfusion Injury
RGS4, a GTPase activator, improves renal function in ischemia-reperfusion injury.
Respiratory Distress Syndrome
Extracellular vesicles released from p18 overexpressing pulmonary endothelial cells are barrier protective - potential implications for acute respiratory distress syndrome.
Retinal Degeneration
A common allele in RPGRIP1L is a modifier of retinal degeneration in ciliopathies.
Retinal Degeneration
A long-term efficacy study of gene replacement therapy for RPGR-associated retinal degeneration.
Retinal Degeneration
A novel form of transducin-dependent retinal degeneration: accelerated retinal degeneration in the absence of rod transducin.
Retinal Degeneration
Canine rod transducin alpha-1: cloning of the cDNA and evaluation of the gene as a candidate for progressive retinal atrophy.
Retinal Degeneration
Defective cone photoreceptor cytoskeleton, alignment, feedback, and energetics can lead to energy depletion in macular degeneration.
Retinal Degeneration
Gelsolin dysfunction causes photoreceptor loss in induced pluripotent cell and animal retinitis pigmentosa models.
Retinal Degeneration
Gypenosides attenuate retinal degeneration in a zebrafish retinitis pigmentosa model.
Retinal Degeneration
Immunological determination of transducin content in retinas exhibiting inherited degeneration.
Retinal Degeneration
Interaction of ciliary disease protein retinitis pigmentosa GTPase regulator with nephronophthisis-associated proteins in mammalian retinas.
Retinal Degeneration
Mutation analysis of the RPGR gene reveals novel mutations in south European patients with X-linked retinitis pigmentosa.
Retinal Degeneration
Overexpression of RPGR leads to male infertility in mice due to defects in flagellar assembly.
Retinal Degeneration
Probing Proteostatic Stress in Degenerating Photoreceptors Using Two Complementary In Vivo Reporters of Proteasomal Activity.
Retinal Degeneration
Reduced level of interphotoreceptor retinoid-binding protein (IRBP), a possible cause for retinal degeneration in the Abyssinian cat.
Retinal Degeneration
Restoration of RPGR expression in vivo using CRISPR/Cas9 gene editing.
Retinal Degeneration
Retinal accumulation of the phosducin/T beta gamma and transducin complexes in developing normal mice and in mice and dogs with inherited retinal degeneration.
Retinal Degeneration
Retinal degeneration in mice expressing the constitutively active G90D rhodopsin mutant.
Retinal Degeneration
Retinitis Pigmentosa GTPase Regulator (RPGR) protein isoforms in mammalian retina: insights into X-linked Retinitis Pigmentosa and associated ciliopathies.
Retinal Degeneration
Rhodopsin accumulation at abnormal sites in retinas of mice with a human P23H rhodopsin transgene.
Retinal Diseases
Discordant Phenotypes in Fraternal Twins Having an Identical Mutation in Exon ORF15 of the RPGR Gene.
Retinal Diseases
Exon screening of the genes encoding the beta- and gamma-subunits of cone transducin in patients with inherited retinal disease.
Retinal Diseases
In Vivo CRISPR/Cas9-Mediated Genome Editing Mitigates Photoreceptor Degeneration in a Mouse Model of X-Linked Retinitis Pigmentosa.
Retinal Diseases
Loss of RPGR glutamylation underlies the pathogenic mechanism of retinal dystrophy caused by TTLL5 mutations.
Retinal Diseases
RPGR-Associated Retinal Degeneration in Human X-Linked RP and a Murine Model.
Retinal Dystrophies
Dark-light: model for nightblindness from the human rhodopsin Gly-90-->Asp mutation.
Retinal Dystrophies
Gelsolin dysfunction causes photoreceptor loss in induced pluripotent cell and animal retinitis pigmentosa models.
Retinal Dystrophies
Rd9 is a naturally occurring mouse model of a common form of retinitis pigmentosa caused by mutations in RPGR-ORF15.
Retinal Dystrophies
Structural and functional plasticity of subcellular tethering, targeting and processing of RPGRIP1 by RPGR isoforms.
Retinal Dystrophies
The retinitis pigmentosa GTPase regulator (RPGR) interacts with novel transport-like proteins in the outer segments of rod photoreceptors.
Retinitis Pigmentosa
A highly polymorphic RFLP marker in the canine retinitis pigmentosa GTPase regulator (RPGR) gene.
Retinitis Pigmentosa
A long-term efficacy study of gene replacement therapy for RPGR-associated retinal degeneration.
Retinitis Pigmentosa
A new 2-base pair deletion in the RPGR gene in a black family with X-linked retinitis pigmentosa.
Retinitis Pigmentosa
A NlaIII PCR/RFLP in an intron of the retinitis pigmentosa GTPase regulator gene (RPGR) on the canine X chromosome.
Retinitis Pigmentosa
A novel de novo frameshift mutation of RPGR ORF15 is associated with X-linked retinitis pigmentosa in a Chinese family.
Retinitis Pigmentosa
A novel homozygous truncating GNAT1 mutation implicated in retinal degeneration.
Retinitis Pigmentosa
A novel missense mutation of RPGR identified from retinitis pigmentosa affects splicing of the ORF15 region and causes loss of transcript heterogeneity.
Retinitis Pigmentosa
A novel mutation in retinitis pigmentosa GTPase regulator gene with a distinctive retinitis pigmentosa phenotype in a Chinese family.
Retinitis Pigmentosa
A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse model for X-linked retinitis pigmentosa (RP3).
Retinitis Pigmentosa
A screen for mutations in the transducin gene GNB1 in patients with autosomal dominant retinitis pigmentosa.
Retinitis Pigmentosa
A single, abbreviated RPGR-ORF15 variant reconstitutes RPGR function in vivo.
Retinitis Pigmentosa
Analysis of genes coding for S-antigen, interstitial retinol binding protein, and the alpha-subunit of cone transducin in patients with retinitis pigmentosa.
Retinitis Pigmentosa
Arl3 and RP2 mediated assembly and traffic of membrane associated cilia proteins.
Retinitis Pigmentosa
ARL3 regulates trafficking of prenylated phototransduction proteins to the rod outer segment.
Retinitis Pigmentosa
Association of a Novel Intronic Variant in RPGR With Hypomorphic Phenotype of X-Linked Retinitis Pigmentosa.
Retinitis Pigmentosa
Association of fat mass and obesity-associated and retinitis pigmentosa guanosine triphosphatase (GTPase) regulator-interacting protein-1 like polymorphisms with body mass index in Chinese women.
Retinitis Pigmentosa
Biochemical characterization and subcellular localization of the mouse retinitis pigmentosa GTPase regulator (mRpgr).
Retinitis Pigmentosa
Canine RPGRIP1 mutation establishes cone-rod dystrophy in miniature longhaired dachshunds as a homologue of human Leber congenital amaurosis.
Retinitis Pigmentosa
Characterization of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa. Mutations on the cytoplasmic surface affect transducin activation.
Retinitis Pigmentosa
Characterization of Visual Function, Interocular Variability and Progression Using Static Perimetry-Derived Metrics in RPGR-Associated Retinopathy.
Retinitis Pigmentosa
Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development.
Retinitis Pigmentosa
Clinical and Electrophysiologic Characteristics of a Large Kindred with X-linked Retinitis Pigmentosa Associated with the RPGR Locus.
Retinitis Pigmentosa
Clinical and genetic characteristics of 14 patients from 13 Japanese families with RPGR-associated retinal disorder: report of eight novel variants.
Retinitis Pigmentosa
Codon-Optimized RPGR Improves Stability and Efficacy of AAV8 Gene Therapy in Two Mouse Models of X-Linked Retinitis Pigmentosa.
Retinitis Pigmentosa
Complete exon-intron structure of the RPGR-interacting protein (RPGRIP1) gene allows the identification of mutations underlying Leber congenital amaurosis.
Retinitis Pigmentosa
Complex expression pattern of RPGR reveals a role for purine-rich exonic splicing enhancers.
Retinitis Pigmentosa
Comprehensive survey of mutations in RP2 and RPGR in patients affected with distinct retinal dystrophies: genotype-phenotype correlations and impact on genetic counseling.
Retinitis Pigmentosa
Contiguous Xp11.4 Gene Deletion Leading to Ornithine Transcarbamylase Deficiency Detected by High-density Single-nucleotide Array.
Retinitis Pigmentosa
Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated (FTO) and retinitis pigmentosa gtpase regulator interacting protein-1 like (RPGRIPIL) genes, and co-ordinates leptin receptor signaling.
Retinitis Pigmentosa
Defective cone photoreceptor cytoskeleton, alignment, feedback, and energetics can lead to energy depletion in macular degeneration.
Retinitis Pigmentosa
Detailed comparison of phenotype between male patients carrying variants in exons 1-14 and ORF15 of RPGR.
Retinitis Pigmentosa
Development of a Reporter System to Explore MMEJ in the Context of Replacing Large Genomic Fragments.
Retinitis Pigmentosa
Discordant Phenotypes in Fraternal Twins Having an Identical Mutation in Exon ORF15 of the RPGR Gene.
Retinitis Pigmentosa
Disease expression in X-linked retinitis pigmentosa caused by a putative null mutation in the RPGR gene.
Retinitis Pigmentosa
Disease mechanisms of X-linked retinitis pigmentosa due to RP2 and RPGR mutations.
Retinitis Pigmentosa
DNA sequence comparison of human and mouse retinitis pigmentosa GTPase regulator (RPGR) identifies tissue-specific exons and putative regulatory elements.
Retinitis Pigmentosa
Dose Range Finding Studies with Two RPGR Transgenes in a Canine Model of X-Linked Retinitis Pigmentosa Treated with Subretinal Gene Therapy.
Retinitis Pigmentosa
Early-onset X-linked Retinitis Pigmentosa in a Heterozygous Female Harboring an Intronic Donor Splice Site Mutation in the Retinitis Pigmentosa GTPase Regulator Gene.
Retinitis Pigmentosa
Evaluation of splicing efficiency in lymphoblastoid cell lines from patients with splicing-factor retinitis pigmentosa.
Retinitis Pigmentosa
Evidence for RPGRIP1 gene as risk factor for primary open angle glaucoma.
Retinitis Pigmentosa
Evolutionary Characterization of the Retinitis Pigmentosa GTPase Regulator Gene.
Retinitis Pigmentosa
Exploring the Variable Phenotypes of RPGR Carrier Females in Assessing their Potential for Retinal Gene Therapy.
Retinitis Pigmentosa
Expression and characterization of human PDEdelta and its Caenorhabditis elegans ortholog CEdelta.
Retinitis Pigmentosa
Expression and localization of the ciliary disease protein retinitis pigmentosa GTPase regulator in mammalian kidney.
Retinitis Pigmentosa
Fine mapping of canine XLPRA establishes homology of the human and canine RP3 intervals.
Retinitis Pigmentosa
Gelsolin dysfunction causes photoreceptor loss in induced pluripotent cell and animal retinitis pigmentosa models.
Retinitis Pigmentosa
Gene replacement therapy rescues photoreceptor degeneration in a murine model of Leber congenital amaurosis lacking RPGRIP.
Retinitis Pigmentosa
Gene Therapeutic Approach Using Mutation-adapted U1 snRNA to Correct a RPGR Splice Defect in Patient-derived Cells.
Retinitis Pigmentosa
Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa.
Retinitis Pigmentosa
Genetic analysis of Chinese families reveals a novel truncation allele of the retinitis pigmentosa GTPase regulator gene.
Retinitis Pigmentosa
Genetic association of the gene encoding RPGRIP1L with susceptibility to vascular dementia.
Retinitis Pigmentosa
Gypenosides attenuate retinal degeneration in a zebrafish retinitis pigmentosa model.
Retinitis Pigmentosa
High Symmetry of Visual Acuity and Visual Fields in RPGR-Linked Retinitis Pigmentosa.
Retinitis Pigmentosa
Homozygous females for a X-linked RPGR-ORF15 mutation in an Iranian family with retinitis pigmentosa.
Retinitis Pigmentosa
Human retinopathy-associated ciliary protein Retinitis Pigmentosa GTPase Regulator (RPGR) regulates cilia-dependent vertebrate development.
Retinitis Pigmentosa
Identification and characterization of a novel RPGR isoform in human retina.
Retinitis Pigmentosa
Identification of a cytogenetic deletion and of four novel mutations (Q69X, I172F, G188V, G197R) affecting the gene for ornithine transcarbamylase (OTC) in Spanish patients with OTC deficiency.
Retinitis Pigmentosa
Identification of a novel RPGR exon ORF15 mutation in a family with X-linked retinitis pigmentosa.
Retinitis Pigmentosa
Identification of a novel RPGRIP1 mutation in an Iranian family with leber congenital amaurosis by exome sequencing.
Retinitis Pigmentosa
Identification of novel RPGR (retinitis pigmentosa GTPase regulator) mutations in a subset of X-linked retinitis pigmentosa families segregating with the RP3 locus.
Retinitis Pigmentosa
Identification of novel X-linked gain-of-function RPGR-ORF15 mutation in Italian family with retinitis pigmentosa and pathologic myopia.
Retinitis Pigmentosa
Identification of proteins in retinas and IPM from eyes with retinitis pigmentosa.
Retinitis Pigmentosa
In Vivo CRISPR/Cas9-Mediated Genome Editing Mitigates Photoreceptor Degeneration in a Mouse Model of X-Linked Retinitis Pigmentosa.
Retinitis Pigmentosa
Insights into X-linked retinitis pigmentosa type 3, allied diseases and underlying pathomechanisms.
Retinitis Pigmentosa
Interaction of ciliary disease protein retinitis pigmentosa GTPase regulator with nephronophthisis-associated proteins in mammalian retinas.
Retinitis Pigmentosa
Interaction of retinitis pigmentosa GTPase regulator (RPGR) with RAB8A GTPase: implications for cilia dysfunction and photoreceptor degeneration.
Retinitis Pigmentosa
Isolation of retinal proteins that interact with retinitis pigmentosa GTPase regulator by interaction trap screen in yeast.
Retinitis Pigmentosa
Limited proteolysis differentially modulates the stability and subcellular localization of domains of RPGRIP1 that are distinctly affected by mutations in Leber's congenital amaurosis.
Retinitis Pigmentosa
Localizing the RPGR protein along the cilium: a new method to determine efficacies to treat RPGR mutations.
Retinitis Pigmentosa
Loss of human disease protein retinitis pigmentosa GTPase regulator (RPGR) differentially affects rod or cone-enriched retina.
Retinitis Pigmentosa
Loss of RPGR glutamylation underlies the pathogenic mechanism of retinal dystrophy caused by TTLL5 mutations.
Retinitis Pigmentosa
Mapping of X-linked progressive retinal atrophy (XLPRA), the canine homolog of retinitis pigmentosa 3 (RP3).
Retinitis Pigmentosa
Membrane protein transport in photoreceptors: the function of PDE?: the Proctor lecture.
Retinitis Pigmentosa
Misexpression of the constitutive rpgrex1-19 variant leads to severe photoreceptor degeneration.
Retinitis Pigmentosa
Modeling retinitis pigmentosa through patient-derived retinal organoids.
Retinitis Pigmentosa
Multiprotein Complexes of Retinitis Pigmentosa GTPase Regulator (RPGR), a Ciliary Protein Mutated in X-Linked Retinitis Pigmentosa (XLRP).
Retinitis Pigmentosa
Muscular dystrophy in the Japanese Spitz: an inversion disrupts the DMD and RPGR genes.
Retinitis Pigmentosa
Mutation analysis of the RPGR gene reveals novel mutations in south European patients with X-linked retinitis pigmentosa.
Retinitis Pigmentosa
Mutational risk in highly repetitive exon ORF15 of the RPGR multidisease gene is not associated with haplotype background.
Retinitis Pigmentosa
Mutations in DNAH5 account for only 15% of a non-preselected cohort of patients with primary ciliary dyskinesia.
Retinitis Pigmentosa
Mutations in the X-linked retinitis pigmentosa genes RPGR and RP2 found in 8.5% of families with a provisional diagnosis of autosomal dominant retinitis pigmentosa.
Retinitis Pigmentosa
Mutations that are a common cause of Leber congenital amaurosis in northern America are rare in Southern India.
Retinitis Pigmentosa
Natural History Study of Retinal Structure, Progression, and Symmetry Using Ellipzoid Zone Metrics in RPGR-Associated Retinopathy.
Retinitis Pigmentosa
Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin.
Retinitis Pigmentosa
Novel Mutation in Retinitis Pigmentosa GTPase Regulator Gene Causes Primary Ciliary Dyskinesia and Retinitis Pigmentosa.
Retinitis Pigmentosa
Novel mutations of RPGR in Chinese families with X-linked retinitis pigmentosa.
Retinitis Pigmentosa
Novel mutations of RPGR in Chinese retinitis pigmentosa patients and the genotype-phenotype correlation.
Retinitis Pigmentosa
Novel variants of RPGR in X-linked retinitis pigmentosa families and genotype-phenotype correlation.
Retinitis Pigmentosa
Overexpression of RPGR leads to male infertility in mice due to defects in flagellar assembly.
Retinitis Pigmentosa
Phenotypic variation and genotype-phenotype discordance in canine cone-rod dystrophy with an RPGRIP1 mutation.
Retinitis Pigmentosa
Photoreceptor cGMP phosphodiesterase delta subunit (PDEdelta) functions as a prenyl-binding protein.
Retinitis Pigmentosa
Population genetics of Cryptosporidium meleagridis in humans and birds: evidence for cross-species transmission.
Retinitis Pigmentosa
Population haplotypes of exon ORF15 of the retinitis pigmentosa GTPase regulator gene in Germany : implications for screening for inherited retinal disorders.
Retinitis Pigmentosa
QUANTITATIVE ANALYSIS OF HYPERAUTOFLUORESCENT RINGS TO CHARACTERIZE THE NATURAL HISTORY AND PROGRESSION IN RPGR-ASSOCIATED RETINOPATHY.
Retinitis Pigmentosa
Quantitative Analysis of Retinal Structure Using Spectral-Domain Optical Coherence Tomography in RPGR-Associated Retinopathy.
Retinitis Pigmentosa
Rd9 is a naturally occurring mouse model of a common form of retinitis pigmentosa caused by mutations in RPGR-ORF15.
Retinitis Pigmentosa
Reliability and Repeatability of Cone Density Measurements in Patients With Stargardt Disease and RPGR-Associated Retinopathy.
Retinitis Pigmentosa
Research progress on human genes involved in the pathogenesis of glaucoma (Review).
Retinitis Pigmentosa
Restoration of RPGR expression in vivo using CRISPR/Cas9 gene editing.
Retinitis Pigmentosa
Retinitis Pigmentosa GTPase Regulator (RPGR) protein isoforms in mammalian retina: insights into X-linked Retinitis Pigmentosa and associated ciliopathies.
Retinitis Pigmentosa
Retinitis pigmentosa GTPase regulator (RPGRr)-interacting protein is stably associated with the photoreceptor ciliary axoneme and anchors RPGR to the connecting cilium.
Retinitis Pigmentosa
Rod and cone opsin mislocalization in an autopsy eye from a carrier of X-linked retinitis pigmentosa with a Gly436Asp mutation in the RPGR gene.
Retinitis Pigmentosa
RPGR is mutated in patients with a complex X linked phenotype combining primary ciliary dyskinesia and retinitis pigmentosa.
Retinitis Pigmentosa
RPGR isoform imbalance causes ciliary defects due to exon ORF15 mutations in X-linked retinitis pigmentosa (XLRP).
Retinitis Pigmentosa
RPGR isoforms in photoreceptor connecting cilia and the transitional zone of motile cilia.
Retinitis Pigmentosa
RPGR ORF15 Genotype and Clinical Variability of Retinal Degeneration in an Australian Population.
Retinitis Pigmentosa
RPGR transcription studies in mouse and human tissues reveal a retina-specific isoform that is disrupted in a patient with X-linked retinitis pigmentosa.
Retinitis Pigmentosa
RPGR-Associated Retinal Degeneration in Human X-Linked RP and a Murine Model.
Retinitis Pigmentosa
RPGR-associated retinopathy: clinical features, molecular genetics, animal models and therapeutic options.
Retinitis Pigmentosa
RPGR-containing protein complexes in syndromic and non-syndromic retinal degeneration due to ciliary dysfunction.
Retinitis Pigmentosa
RPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC1, SMC3, and microtubule transport proteins.
Retinitis Pigmentosa
RPGR: Its role in photoreceptor physiology, human disease, and future therapies.
Retinitis Pigmentosa
RPGR: role in the photoreceptor cilium, human retinal disease, and gene therapy.
Retinitis Pigmentosa
RPGRIP1 is essential for normal rod photoreceptor outer segment elaboration and morphogenesis.
Retinitis Pigmentosa
RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis.
Retinitis Pigmentosa
RpgrORF15 connects to the Usher protein network through direct interactions with multiple whirlin isoforms.
Retinitis Pigmentosa
Screening for mutations in RPGR and RP2 genes in Jordanian families with X-linked retinitis pigmentosa.
Retinitis Pigmentosa
Selective loss of RPGRIP1-dependent ciliary targeting of NPHP4, RPGR and SDCCAG8 underlies the degeneration of photoreceptor neurons.
Retinitis Pigmentosa
Severe manifestations in carrier females in X linked retinitis pigmentosa.
Retinitis Pigmentosa
Spata7 is a retinal ciliopathy gene critical for correct RPGRIP1 localization and protein trafficking in the retina.
Retinitis Pigmentosa
Species-specific subcellular localization of RPGR and RPGRIP isoforms: implications for the phenotypic variability of congenital retinopathies among species.
Retinitis Pigmentosa
Spectrum of mutations in the RPGR gene that are identified in 20% of families with X-linked retinitis pigmentosa.
Retinitis Pigmentosa
Structural and functional plasticity of subcellular tethering, targeting and processing of RPGRIP1 by RPGR isoforms.
Retinitis Pigmentosa
Structure of a multipartite protein-protein interaction domain in splicing factor prp8 and its link to retinitis pigmentosa.
Retinitis Pigmentosa
Successful arrest of photoreceptor and vision loss expands the therapeutic window of retinal gene therapy to later stages of disease.
Retinitis Pigmentosa
Successful gene therapy in the RPGRIP1-deficient dog, a large model of cone-rod dystrophy.
Retinitis Pigmentosa
Symptoms of OTC deficiency but not DMD in a female carrier of an Xp21.1 deletion including the genes for dystrophin and OTC.
Retinitis Pigmentosa
The clinical application of preimplantation genetic diagnosis for X-linked retinitis pigmentosa.
Retinitis Pigmentosa
The cyclophilin-like domain of Ran-binding protein-2 modulates selectively the activity of the ubiquitin-proteasome system and protein biogenesis.
Retinitis Pigmentosa
The human retinitis pigmentosa GTPase regulator gene variant database.
Retinitis Pigmentosa
The interplay between RPGR, PDE? and Arl2/3 regulate the ciliary targeting of farnesylated cargo.
Retinitis Pigmentosa
The Major Ciliary Isoforms of RPGR Build Different Interaction Complexes with INPP5E and RPGRIP1L.
Retinitis Pigmentosa
The retinitis pigmentosa GTPase regulator (RPGR) interacts with novel transport-like proteins in the outer segments of rod photoreceptors.
Retinitis Pigmentosa
The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: subserving RPGR function and participating in disk morphogenesis.
Retinitis Pigmentosa
The retinitis pigmentosa GTPase regulator interacting protein 1 (RPGRIP1) links RPGR to the nephronophthisis protein network.
Retinitis Pigmentosa
The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase.
Retinitis Pigmentosa
The retinitis pigmentosa protein RP2 links pericentriolar vesicle transport between the Golgi and the primary cilium.
Retinitis Pigmentosa
The X-linked retinitis pigmentosa protein RP2 facilitates G protein traffic.
Retinitis Pigmentosa
Three novel mutations of the RPGR gene exon ORF15 in three Japanese families with X-linked retinitis pigmentosa.
Retinitis Pigmentosa
Toxicity and Efficacy Evaluation of an Adeno-Associated Virus Vector Expressing Codon-Optimized RPGR Delivered by Subretinal Injection in a Canine Model of X-linked Retinitis Pigmentosa.
Retinitis Pigmentosa
Toxicology and Pharmacology of an AAV Vector Expressing Codon-Optimized RPGR in RPGR-Deficient Rd9 Mice.
Retinitis Pigmentosa
Two novel mutations in the retinitis pigmentosa GTPase regulator (RPGR) gene in X-linked retinitis pigmentosa (RP3). Mutations in brief no. 172. Online.
Retinitis Pigmentosa
Two novel mutations of the retinitis pigmentosa GTPase regulator gene in two Chinese families with X-linked retinitis pigmentosa.
Retinitis Pigmentosa
Upregulation of Mark3 and Rpgrip1 mRNA expression by jujuboside A in mouse hippocampus.
Retinitis Pigmentosa
Use of induced pluripotent stem-cell technology to understand photoreceptor cytoskeletal dynamics in retinitis pigmentosa.
Retinitis Pigmentosa
Versatile screening for binary protein-protein interactions by yeast two-hybrid mating.
Retinitis Pigmentosa
X-linked retinitis pigmentosa in two families with a missense mutation in the RPGR gene and putative change of glycine to valine at codon 60.
Retinitis Pigmentosa
X-linked retinitis pigmentosa: RPGR mutations in most families with definite X linkage and clustering of mutations in a short sequence stretch of exon ORF15.
Retinitis Pigmentosa
Zebrafish Model for the Genetic Basis of X-Linked Retinitis Pigmentosa.
Retinoblastoma
Bidirectional regulation of c-fos promoter by an oncogenic gip2 mutant of G alpha i2. A novel implication of retinoblastoma gene product.
Retinoschisis
Photoreceptor Pathology in the X-Linked Retinoschisis (XLRS) Mouse Results in Delayed Rod Maturation and Impaired Light Driven Transducin Translocation.
Rheumatic Heart Disease
Expression of the angiotensin II, rac GTPase activating protein 1, signal transducer and activator of transcription 3 signaling pathway in patients with permanent atrial fibrillation and rheumatic heart disease.
RNA Virus Infections
Respiratory syncytial virus strain A2 is resistant to the antiviral effects of type I interferons and human MxA.
Sarcoma
A barley SKP1-like protein controls abundance of the susceptibility factor RACB and influences the interaction of barley with the barley powdery mildew fungus.
Sarcoma
Association of elongation factor 2 with ribosomes during growth of a murine ascitic tumor.
Sarcoma
Detection of KRAS Mutations in Circulating Tumor DNA by Digital PCR in Early Stages of Pancreatic Cancer.
Sarcoma
Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.
Sarcoma
Primary alveolar macrophages exposed to diesel particulate matter increase RAGE expression and activate RAGE signaling.
Sarcoma
The use of protein-DNA, chromatin immunoprecipitation, and transcriptome arrays to describe transcriptional circuits in the dehydrated male rat hypothalamus.
Sarcoma, Avian
Infection of neuroretinal cells in vitro by avian sarcoma viruses UR1 and UR2: transformation, cell growth stimulation, and changes in transducin levels.
Sarcoma, Avian
Partial sequence homologies between cytoskeletal proteins, c-myc, Rous sarcoma virus and adenovirus proteins, transducin, and beta- and gamma-crystallins.
Scoliosis
Hyperactive Ras/MAPK signaling is critical for tibial nonunion fracture in neurofibromin-deficient mice.
Scoliosis
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Seizures
Brain region-specific and time-dependent decreases of G alpha i2 in amygdala-kindled rats.
Seizures
De novo missense variant in the GTPase effector domain (GED) of DNM1L leads to static encephalopathy and seizures.
Seizures
Loss of Cannabinoid CB 1 Receptors Induces Cortical Migration Malformations and Increases Seizure Susceptibility.
Sepsis
The GTPase Rab1 Is Required for NLRP3 Inflammasome Activation and Inflammatory Lung Injury.
Sepsis
[Role of immune-related GTPase M1 in cortical neurons autophagy of mice with sepsis-induced brain injury].
Sepsis-Associated Encephalopathy
Regulation of hippocampal neuronal apoptosis and autophagy in mice with sepsis-associated encephalopathy by immunity-related GTPase M1.
Shwachman-Diamond Syndrome
Cooperative energetic effects elicited by the yeast Shwachman-Diamond syndrome protein (Sdo1) and guanine nucleotides modulate the complex conformational landscape of the elongation factor-like 1 (Efl1) GTPase.
Shwachman-Diamond Syndrome
Defective Guanine Nucleotide Exchange in the Elongation Factor-like 1 (EFL1) GTPase by Mutations in the Shwachman-Diamond Syndrome Protein.
Shwachman-Diamond Syndrome
EFL1 mutations impair eIF6 release to cause Shwachman-Diamond syndrome.
Shwachman-Diamond Syndrome
Fluorescence Anisotropy as a Tool to Study Protein-protein Interactions.
Shwachman-Diamond Syndrome
Guanine nucleotide exchange in the ribosomal GTPase EFL1 is modulated by the protein mutated in the Shwachman-Diamond Syndrome.
Shwachman-Diamond Syndrome
Interaction of the GTPase Elongation Factor Like-1 with the Shwachman-Diamond Syndrome Protein and Its Missense Mutations.
Sleep Deprivation
Transcriptional alterations of genes related to fertility decline in male rats induced by chronic sleep restriction.
Small Cell Lung Carcinoma
Heterotrimeric G-protein, G?16, is a critical downstream effector of non-canonical Wnt signaling and a potent inhibitor of transformed cell growth in non small cell lung cancer.
Spastic Paraplegia, Hereditary
Atlastin GTPases are required for Golgi apparatus and ER morphogenesis.
Spastic Paraplegia, Hereditary
Characterization of a novel SPG3A deletion in a French-Canadian family.
Spastic Paraplegia, Hereditary
ER network formation and membrane fusion by atlastin1/SPG3A disease variants.
Spastic Paraplegia, Hereditary
Homozygous mutation in Atlastin GTPase 1 causes recessive hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Loss of Dynamin 2 GTPase function results in microcytic anaemia.
Spastic Paraplegia, Hereditary
Loss of the Mitochondrial Fission GTPase Drp1 Contributes to Neurodegeneration in a Drosophila Model of Hereditary Spastic Paraplegia.
Spastic Paraplegia, Hereditary
Mutations in a newly identified GTPase gene cause autosomal dominant hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Novel mutation in the ATL1 with autosomal dominant hereditary spastic paraplegia presented as dysautonomia.
Spastic Paraplegia, Hereditary
Novel mutation in the SPG3A gene in an African American family with an early onset of hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Pharmacologic rescue of axon growth defects in a human iPSC model of hereditary spastic paraplegia SPG3A.
Spastic Paraplegia, Hereditary
SPG3A mutation screening in English families with early onset autosomal dominant hereditary spastic paraplegia.
Squamous Cell Carcinoma of Head and Neck
Immunohistochemical study of RhoC GTPase in oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Role of IQGAP1 in Papillomavirus-Associated Head and Neck Tumorigenesis.
Stargardt Disease
Mapping of the human cone transducin alpha-subunit (GNAT2) gene to 1p13 and negative mutation analysis in patients with Stargardt disease.
Stargardt Disease
Reliability and Repeatability of Cone Density Measurements in Patients With Stargardt Disease and RPGR-Associated Retinopathy.
Starvation
Elongation factor 2 in the liver and skeletal muscle of mice is decreased by starvation.
Starvation
Feedback Inhibition of the Rag GTPase GAP Complex Lst4-Lst7 Safeguards TORC1 from Hyperactivation by Amino Acid Signals.
Starvation
Heterotrimeric G protein mediated regulation of proteinase production in Aspergillus nidulans.
Starvation
Lack of starvation-induced activation of AMP-activated protein kinase in the hypothalamus of the Lou/C rats resistant to obesity.
Starvation
Loss of Rhb1, a Rheb-related GTPase in fission yeast, causes growth arrest with a terminal phenotype similar to that caused by nitrogen starvation.
Starvation
Obg and Membrane Depolarization Are Part of a Microbial Bet-Hedging Strategy that Leads to Antibiotic Tolerance.
Starvation
RGS4 controls G?i3-mediated regulation of Bcl-2 phosphorylation on TGN38-containing intracellular membranes.
Starvation
Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9.
Starvation
TBC-2 is required for embryonic yolk protein storage and larval survival during L1 diapause in Caenorhabditis elegans.
Starvation
The G-protein beta subunit GPB1 is required for mating and haploid fruiting in Cryptococcus neoformans.
Starvation
The Interaction between the Ribosomal Stalk Proteins and Translation Initiation Factor 5B Promotes Translation Initiation.
Starvation
The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae.
Starvation
The ObgE/CgtA GTPase influences the stringent response to amino acid starvation in Escherichia coli.
Starvation
The Small Yeast GTPase Rho5 and Its Dimeric GEF Dck1/Lmo1 Respond to Glucose Starvation.
Stomach Neoplasms
ALEX1, a novel tumor suppressor gene, inhibits gastric cancer metastasis via the PAR-1/Rho GTPase signaling pathway.
Stomach Neoplasms
Anti-metastasis effects of gallic acid on gastric cancer cells involves inhibition of NF-kappaB activity and downregulation of PI3K/AKT/small GTPase signals.
Stomach Neoplasms
Dichotomous roles of claudins as tumor promoters or suppressors: lessons from knockout mice.
Stomach Neoplasms
Elevated expression of immunity-related GTPase family M in gastric cancer.
Stomach Neoplasms
Expression analysis and implication of Rab1A in gastrointestinal relevant tumor.
Stomach Neoplasms
Expression of two types of neurofibromatosis type 1 gene transcripts in gastric cancers and comparison of GAP activities.
Stomach Neoplasms
Gallic acid inhibits gastric cancer cells metastasis and invasive growth via increased expression of RhoB, downregulation of AKT/small GTPase signals and inhibition of NF-?B activity.
Stomach Neoplasms
IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL.
Stomach Neoplasms
Long non?coding RNA lnc?GNAT1?1 inhibits gastric cancer cell proliferation and invasion through the Wnt/??catenin pathway in Helicobacter pylori infection.
Stomach Neoplasms
Lysophosphatidic acid promotes cell invasion by up-regulating the urokinase-type plasminogen activator receptor in human gastric cancer cells.
Stomach Neoplasms
Overexpression of Mitochondrial GTPase MFN2 Represents a Negative Prognostic Marker in Human Gastric Cancer and Its Inhibition Exerts Anti-Cancer Effects.
Stomach Neoplasms
Prognosis Significance and Positive Correlation of Rab1A and p-S6K/Gli1 Expression in Gastric Cancer.
Stomach Neoplasms
Rab1A knockdown represses proliferation and promotes apoptosis in gastric cancer cells by inhibition of mTOR/p70S6K pathway.
Stomach Neoplasms
Significance and prognostic role of human epidermal growth factor receptor 2 and RAB1A expression in gastric cancer.
Stomach Neoplasms
TBL1XR1 is involved in c-Met-mediated tumorigenesis of human nonsmall cell lung cancer.
Stomach Neoplasms
Transducin (?)-like 1 X-linked receptor 1 promotes gastric cancer progression via the ERK1/2 pathway.
Stroke
Astrocyte-Derived Exosomes Treated With a Semaphorin 3A Inhibitor Enhance Stroke Recovery via Prostaglandin D2 Synthase.
Stroke
Development of a cell transducible RhoA inhibitor TAT-C3 transferase and its encapsulation in biocompatible microspheres to promote survival and enhance regeneration of severed neurons.
Stroke
Immune-related GTPase M (IRGM1) regulates neuronal autophagy in a mouse model of stroke.
Stroke
Statin treatment before stroke reduces pro-inflammatory cytokine levels after stroke.
Stroke
Synchronous tRNA movements during translocation on the ribosome are orchestrated by elongation factor G and GTP hydrolysis.
Tachycardia
HSPB1, HSPB6, HSPB7 and HSPB8 protect against RhoA GTPase-induced remodeling in tachypaced atrial myocytes.
Tardive Dyskinesia
D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways.
Tauopathies
Photodynamic treatment modulates various GTPase and cellular signalling pathways in Tauopathy.
Teratocarcinoma
Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat.
Teratocarcinoma
Human septin 3 on chromosome 22q13.2 is upregulated by neuronal differentiation.
Teratocarcinoma
Regulation of the differentiation of teratocarcinoma cells into primitive endoderm by G alpha i2.
Teratocarcinoma
Retinoic acid stimulates protein kinase A-associated G proteins during human teratocarcinoma differentiation.
Teratocarcinoma
Transcriptional activation of Gs alpha expression by retinoic acid and parathyroid hormone-related protein in F9 teratocarcinoma cells.
Thrombocythemia, Essential
Concomitant presence of JAK2V617F mutation and BCR?ABL translocation in two patients: A new entity or a variant of myeloproliferative neoplasms (Case report).
Thrombocytopenia
Assessment of growth and differentiation processes in myelodysplastic syndromes by PCR analysis of Galpha16 and 5'-lipoxygenase.
Thrombosis
Evaluation of the physiological significance of botrocetin/ von Willebrand factor in vitro signaling.
Thrombosis
Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis.
Thrombosis
Rho GTPase regulation of reactive oxygen species generation and signalling in platelet function and disease.
Thrombosis
[Effect of Dahuangzhechong pill on the gene expression spectra of preventing arterial thrombosis]
Thymoma
Cell quality control mechanisms maintain stemness and differentiation potential of P19 embryonic carcinoma cells.
Thymoma
Emergence of the Dedifferentiated Phenotype in Hepatocyte-Derived Tumors in Mice: Roles of Oncogene-Induced Epigenetic Alterations.
Thyroid Cancer, Papillary
EphB3 Stimulates Cell Migration and Metastasis in a Kinase-dependent Manner through Vav2-Rho GTPase Axis in Papillary Thyroid Cancer.
Thyroid Cancer, Papillary
Next-generation sequencing identified somatic alterations that may underlie the etiology of Chinese papillary thyroid carcinoma.
Thyroid Cancer, Papillary
Rare mutations of the Gs alpha subunit gene in human endocrine tumors. Mutation detection by polymerase chain reaction-primer-introduced restriction analysis.
Thyroid Neoplasms
Activating mutation in the stimulatory guanine nucleotide-binding protein in an infant with Cushing's syndrome and nodular adrenal hyperplasia.
Thyroid Neoplasms
An in vitro model of thyroid neoplasia: permanently transfected FRTL-5 cells with thyroglobulin promoter-cholera toxin A1 subunit minigene.
Thyroid Neoplasms
Constitutive activation of the Gs alpha protein-adenylate cyclase pathway may not be sufficient to generate toxic thyroid adenomas.
Thyroid Neoplasms
Diversity and prevalence of somatic mutations in the thyrotropin receptor and Gs alpha genes as a cause of toxic thyroid adenomas.
Thyroid Neoplasms
Expression of functional stimulatory guanine nucleotide binding protein in nonfunctioning thyroid adenomas is not correlated to adenylate cyclase activity and growth of these tumors.
Thyroid Neoplasms
Functioning and nonfunctioning thyroid adenomas involve different molecular pathogenetic mechanisms.
Thyroid Neoplasms
Low incidence of the stimulatory G protein alpha-subunit mutations in autonomously functioning thyroid adenomas in Japan.
Thyroid Neoplasms
Molecular aspects of the pathogenesis of nodular goiters, thyroid nodules and adenomas.
Thyroid Neoplasms
Prevalences of Gs alpha, ras, p53 mutations and ret/PTC rearrangement in differentiated thyroid tumours in a Korean population.
Thyroid Neoplasms
Structural studies of the thyrotropin receptor and Gs alpha in human thyroid cancers: low prevalence of mutations predicts infrequent involvement in malignant transformation.
Thyroid Neoplasms
Thyroid adenoma, Gs alpha expression and the cyclic adenosine monophosphate mitogenic cascade: a complex relationship.
Thyroid Neoplasms
Thyroid carcinoma in the McCune-Albright syndrome: contributory role of activating Gs alpha mutations.
Thyroid Neoplasms
Thyroid hyperfunctioning adenomas with and without Gsp/TSH receptor mutations show similar clinical features.
Thyroid Neoplasms
Toxic thyroid adenoma: absence of DNA mutations of the TSH receptor and Gs alpha.
Thyroid Neoplasms
[Thyroid carcinoma: genetics, diagnosis, clinical features, and surgical treatment]
Thyroid Nodule
Functioning and nonfunctioning thyroid adenomas involve different molecular pathogenetic mechanisms.
Thyroid Nodule
Somatic mutations in the thyrotropin receptor gene and not in the Gs alpha protein gene in 31 toxic thyroid nodules.
Tics
Constitutive activation of Myosin-dependent contractility sensitizes glioma tumor-initiating cells to mechanical inputs and reduces tissue invasion.
Tooth Diseases
The Charcot-Marie Tooth Disease Mutation R94Q in MFN2 Decreases ATP Production but Increases Mitochondrial Respiration under Conditions of Mild Oxidative Stress.
Toxoplasmosis
STAT1 plays a critical role in the regulation of antimicrobial effector mechanisms, but not in the development of Th1-type responses during toxoplasmosis.
transaldolase deficiency
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Triple Negative Breast Neoplasms
ARF1 regulates adhesion of MDA-MB-231 invasive breast cancer cells through formation of focal adhesions.
Triple Negative Breast Neoplasms
Inhibition of RAB1A suppresses epithelial-mesenchymal transition and proliferation of triple-negative breast cancer cells.
Tuberculosis
Association between genetic variants in the IRGM gene and tuberculosis in a Korean population.
Tuberculosis
Association of autophagy-related IRGM polymorphisms with latent versus active tuberculosis infection in a Chinese population.
Tuberculosis
Candidate biomarkers for discrimination between infection and disease caused by Mycobacterium tuberculosis.
Tuberculosis
Characterization of Ffh of Mycobacterium tuberculosis and its interaction with 4.5S RNA.
Tuberculosis
Cloning and characterization of engA, a GTP-binding protein from Mycobacterium tuberculosis H(37)Rv.
Tuberculosis
Cloning and characterization of GTP-binding proteins of Mycobacterium tuberculosis H(37)Rv.
Tuberculosis
Identification of a novel IRGM promoter single nucleotide polymorphism associated with tuberculosis.
Tuberculosis
Identification of Mycobacterium tuberculosis counterimmune (cim) mutants in immunodeficient mice by differential screening.
Tuberculosis
IRGM gene polymorphisms and haplotypes associate with susceptibility of pulmonary tuberculosis in Chinese Hubei Han population.
Tuberculosis
Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling.
Tuberculosis
Mycobacterium tuberculosis PE31 (Rv3477) Attenuates Host Cell Apoptosis and Promotes Recombinant M. smegmatis Intracellular Survival via Up-regulating GTPase Guanylate Binding Protein-1.
Tuberculosis
Mycobacterium tuberculosis PE_PGRS20 and PE_PGRS47 Proteins Inhibit Autophagy by Interaction with Rab1A.
Tuberculosis
The C-terminally truncated MtFtsZ-DeltaC169 mutant of Mycobacterium tuberculosis FtsZ shows GTPase and GTP-induced, GTP-specific polymerization activities in vitro.
Tuberous Sclerosis
A novel missense mutation in the GTPase activating protein homology region of TSC2 in two large families with tuberous sclerosis complex.
Tuberous Sclerosis
Characterization of the intrinsic and TSC2-GAP-regulated GTPase activity of Rheb by real-time NMR.
Tuberous Sclerosis
Inducible nitric oxide synthase drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2.
Tuberous Sclerosis
Molecular mechanisms through which amino acids mediate signaling through the mammalian target of rapamycin.
Tuberous Sclerosis
Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast.
Tuberous Sclerosis
Rap1 activity is elevated in malignant astrocytomas independent of tuberous sclerosis complex-2 gene expression.
Tuberous Sclerosis
Reciprocal Regulation of AMP-activated Protein Kinase and Phospholipase D.
Tuberous Sclerosis
Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex.
Tuberous Sclerosis
Sequence-specific 1H, 13C, and 15N backbone assignment of the activated 21 kDa GTPase rRheb.
Tuberous Sclerosis
Sequence-specific 1H, 13C, and 15N backbone assignment of the GTPase rRheb in its GDP-bound form.
Tuberous Sclerosis
Suppression of tumorigenicity by the wild-type tuberous sclerosis 2 (Tsc2) gene and its C-terminal region.
Tuberous Sclerosis
The ERK and Akt Signaling Pathways Function Through Parallel Mechanisms to Promote mTORC1.
Tuberous Sclerosis
The RHEB-mTOR axis regulates expression of Tf2 transposons in fission yeast.
Tuberous Sclerosis
The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis.
Tuberous Sclerosis
Tsc2 expression increases the susceptibility of renal tumor cells to apoptosis.
Tuberous Sclerosis
Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease.
Urinary Bladder Neoplasms
Eight-plex iTRAQ labeling and quantitative proteomic analysis for human bladder cancer.
Urinary Bladder Neoplasms
Expression of Rab1A in bladder cancer and its clinical implications.
Urinary Bladder Neoplasms
Long Noncoding RNA MNX1 antisense RNA 1 Exerts Oncogenic Functions in Bladder Cancer by Regulating miR-218-5p/RAB1A Axis.
Urinary Bladder Neoplasms
Mass spectroscopic phosphoprotein mapping of Ral binding protein 1 (RalBP1/Rip1/RLIP76).
Urinary Bladder Neoplasms
Mitofusin 2 inhibits bladder cancer cell proliferation and invasion via the Wnt/?-catenin pathway.
Urinary Bladder Neoplasms
The long noncoding RNA KTN1-AS1 promotes bladder cancer tumorigenesis via KTN1 cis-activation and the consequent initiation of Rho GTPase-mediated signaling.
Urinary Retention
Urinary Retention, Incontinence, and Dysregulation of Muscarinic Receptors in Male Mice Lacking Mras.
Usher Syndromes
Detection of cone alpha transducin mRNA in human fetal cochlea: negative mutation analysis in Usher syndrome.
Uterine Cervical Neoplasms
BRIP1 inhibits the tumorigenic properties of cervical cancer by regulating RhoA GTPase activity.
Uterine Cervical Neoplasms
The effect of RhoC siRNA on the invasiveness and proliferation of human cervical cancer cell line SiHa cells.
Vaccinia
Drosophila stimulatory G protein alpha subunit activates mammalian adenylyl cyclase but interacts poorly with mammalian receptors: implications for receptor-G protein interaction.
Vaccinia
RAB1A promotes Vaccinia virus replication by facilitating the production of intracellular enveloped virions.
Vascular Diseases
Identification of novel signalling roles and targets for G(?) and G(??) downstream of the insulin-like growth factor 1 receptor in vascular smooth muscle cells.
Ventricular Dysfunction
Markedly increased Rho-kinase activity in circulating leukocytes in patients with chronic heart failure.
Vesicular Stomatitis
Conditional expression of type I interferon-induced bovine Mx1 GTPase in a stable transgenic vero cell line interferes with replication of vesicular stomatitis virus.
Vesicular Stomatitis
Enzymatic characterization of interferon-induced antiviral GTPases murine Mx1 and human MxA proteins.
Vesicular Stomatitis
Formation of guanosine(5')tetraphospho(5')adenosine cap structure by an unconventional mRNA capping enzyme of vesicular stomatitis virus.
Vesicular Stomatitis
GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex.
Vesicular Stomatitis
Rab1 and Ca2+ are required for the fusion of carrier vesicles mediating endoplasmic reticulum to Golgi transport.
Vesicular Stomatitis
Switch in antiviral specificity of a GTPase upon translocation from the cytoplasm to the nucleus.
Virus Diseases
Alterations in G-protein-regulated transmembrane signalling induced in murine myocardium by coxsackievirus B3 infection.
Virus Diseases
Effects of immunostimulants targeting Ran GTPase on phagocytosis against virus infection in shrimp.
Virus Diseases
eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation.
Virus Diseases
Influenza Virus Induces Cholesterol-Enriched Endocytic Recycling Compartments for Budozone Formation via Cell Cycle-Independent Centrosome Maturation.
Virus Diseases
Interferon-inducible GTPase: a novel viral response protein involved in rabies virus infection.
Virus Diseases
Myxovirus resistance protein A activates type I IFN signaling pathway to inhibit zika virus replication.
Virus Diseases
Over-expression of GTP-binding proteins and GTPase activity in mouse astrocyte membranes in response to Theiler's murine encephalomyelitis virus infection.
Virus Diseases
Ran GTPase Regulates Hemocytic Phagocytosis of Shrimp by Interaction with Myosin.
Virus Diseases
Role of GTPase activity of murine Mx1 protein in nuclear localization and anti-influenza virus activity.
Virus Diseases
Small rho GTPases and cholesterol biosynthetic pathway intermediates in African swine fever virus infection.
Virus Diseases
Structural analysis of tumor-related single amino acid mutations in human MxA protein.
Whooping Cough
A cysteine-3 to serine mutation of the G-protein Gi1 alpha abrogates functional activation by the alpha 2A-adrenoceptor but not interactions with the beta gamma complex.
Whooping Cough
A Galphas protein-coupled membrane receptor, distinct from the classical oestrogen receptor, transduces rapid effects of oestradiol on [Ca2+]i in female rat distal colon.
Whooping Cough
A novel guanine nucleotide-binding protein coupled to the alpha 1-adrenergic receptor. II. Purification, characterization, and reconstitution.
Whooping Cough
A sensitive method for measuring neutralizing antibodies to Bordetella pertussis toxin: optimized ADP-ribosylation of transducin.
Whooping Cough
A specific beta gamma-subunit of transducin stimulates ADP-ribosylation of the alpha-subunit by pertussis toxin.
Whooping Cough
Acidification of serotonin-containing secretory vesicles induced by a plasma membrane calcium receptor.
Whooping Cough
Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat.
Whooping Cough
Activation of a pertussis-toxin-sensitive guanine-nucleotide-binding regulatory protein during desensitization of Dictyostelium discoideum cells to chemotactic signals.
Whooping Cough
Activation of Gi protein by peptide structures of the muscarinic M2 receptor second intracellular loop.
Whooping Cough
Activation of pertussis toxin-sensitive G-proteins in membranes of SH-SY5Y human neuroblastoma cells and bovine transducin by ethanol.
Whooping Cough
Activation of Syk in neutrophils by antineutrophil cytoplasm antibodies occurs via Fcgamma receptors and CD18.
Whooping Cough
Activation of the G(i) heterotrimeric G protein by ANCA IgG F(ab')2 fragments is necessary but not sufficient to stimulate the recruitment of those downstream mediators used by intact ANCA IgG.
Whooping Cough
ADP-ribosyl proteins formed by pertussis toxin are specifically cleaved by mercury ions.
Whooping Cough
ADP-ribosylarginine glycohydrolase catalyzing the release of ADP-ribose from the cholera toxin-modified alpha-subunits of GTP-binding proteins.
Whooping Cough
ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal photoreceptors.
Whooping Cough
Agonist occupation of an alpha2A-adrenoreceptor-Gi1alpha fusion protein results in activation of both receptor-linked and endogenous Gi proteins. Comparisons of their contributions to GTPase activity and signal transduction and analysis of receptor-G protein activation stoichiometry.
Whooping Cough
Alpha 2-C10 adrenergic receptors expressed in rat 1 fibroblasts can regulate both adenylylcyclase and phospholipase D-mediated hydrolysis of phosphatidylcholine by interacting with pertussis toxin-sensitive guanine nucleotide-binding proteins.
Whooping Cough
Alpha2-adrenoceptor agonists stimulate high-affinity GTPase activity in a receptor subtype-selective manner.
Whooping Cough
Amino acid-specific ADP-ribosylation. Sensitivity to hydroxylamine of [cysteine(ADP-ribose)]protein and [arginine(ADP-ribose)]protein linkages.
Whooping Cough
Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins.
Whooping Cough
Antibodies against the carboxyl-terminal 5-kDa peptide of the alpha subunit of transducin crossreact with the 40-kDa but not the 39-kDa guanine nucleotide binding protein from brain.
Whooping Cough
Antibodies which recognize the C-terminus of the inhibitory guanine-nucleotide-binding protein (Gi) demonstrate that opioid peptides and foetal-calf serum stimulate the high-affinity GTPase activity of two separate pertussis-toxin substrates.
Whooping Cough
Antibody-induced activation of beta1 integrin receptors stimulates cAMP-dependent migration of breast cells on laminin-5.
Whooping Cough
Antisense oligodeoxynucleotides to GS protein alpha-subunit sequence accelerate differentiation of fibroblasts to adipocytes.
Whooping Cough
Assignment of functional domains involved in ADP-ribosylation and B-oligomer binding within the carboxyl terminus of the S1 subunit of pertussis toxin.
Whooping Cough
Association of a solubilized prostaglandin E2 receptor from renal medulla with a pertussis toxin-reactive guanine nucleotide regulatory protein.
Whooping Cough
Association of heterotrimeric GTP binding regulatory protein (Go) with mitosis.
Whooping Cough
Association of two pertussis toxin-sensitive G-proteins with the D2-dopamine receptor from bovine striatum.
Whooping Cough
Bacterial lipopolysaccharide-stimulated GTPase activity in RAW 264.7 macrophage membranes.
Whooping Cough
Baculovirus expression and purification of a soluble, mutant G-protein alpha subunit.
Whooping Cough
Biochemical and biological activities of recombinant S1 subunit of pertussis toxin.
Whooping Cough
Biphasic regulation of adenylate cyclase by cholera toxin in neuroblastoma x glioma hybrid cells is due to the activation and subsequent loss of the alpha subunit of the stimulatory GTP binding protein (GS).
Whooping Cough
Block of light responses of salamander rods by pertussis toxin and reversal by nicotinamide.
Whooping Cough
Bradykinin stimulates GTP hydrolysis in NG108-15 membranes by a high-affinity, pertussis toxin-insensitive GTPase.
Whooping Cough
Bradykinin-activated transmembrane signals are coupled via No or Ni to production of inositol 1,4,5-trisphosphate, a second messenger in NG108-15 neuroblastoma-glioma hybrid cells.
Whooping Cough
C-terminal modifications of pertussis toxin-sensitive G-protein alpha-subunits differentially affect immunoreactivity. Evidence against endogenous ADP-ribosylation in human heart, lung, thrombocytes and adipose tissue.
Whooping Cough
Cardiac alpha 1-adrenoceptors stimulate a high-affinity GTPase activity in sarcolemmal membranes from rabbit atrial and ventricular myocytes.
Whooping Cough
Cardioprotection specific for the G protein Gi2 in chronic adrenergic signaling through beta 2-adrenoceptors.
Whooping Cough
Central G-alpha subunit protein-mediated control of cardiovascular function, urine output, and vasopressin secretion in conscious Sprague-Dawley rats.
Whooping Cough
Changes in cAMP formation in mononuclear leukocytes of heart and renal transplant recipients.
Whooping Cough
Characterization of G-protein alpha subunits in the Gq class: expression in murine tissues and in stromal and hematopoietic cell lines.
Whooping Cough
Characterization of the membrane-associated GTPase activity: effects of chemotactic factors and toxins.
Whooping Cough
Characterization of the plasma membrane bound GTPase from rabbit neutrophils. I. Evidence for an Ni-like protein coupled to the formyl peptide, C5a, and leukotriene B4 chemotaxis receptors.
Whooping Cough
Characterization of transducin from bovine retinal rod outer segments. Use of monoclonal antibodies to probe the structure and function of the subunit.
Whooping Cough
Chemoattractant-induced activation of vacuolar H+ pumps and of an H(+)-selective conductance in neutrophils.
Whooping Cough
Chemoattractant-stimulated GTPase activity is decreased on membranes from polymorphonuclear leukocytes incubated in chemoattractant.
Whooping Cough
Chronic exposure of NG 108-15 cells to opiate agonists does not alter the amount of the guanine nucleotide-binding proteins Gi and Go.
Whooping Cough
Chronic exposure of rat glioma C6 cells to cholera toxin induces loss of the alpha-subunit of the stimulatory guanine nucleotide-binding protein (Gs).
Whooping Cough
Cloning and characterization of a cDNA coding for the alpha-subunit of a stimulatory G protein from Schistosoma mansoni.
Whooping Cough
Cloning and characterization of a G protein alpha-subunit-encoding gene from the basidiomycete, Coprinus congregatus.
Whooping Cough
Cloning of a molluscan G protein alpha subunit of the Gq class which is expressed differentially in identified neurons.
Whooping Cough
Colony-stimulating factor 1-induced Na+ influx into human monocytes involves activation of a pertussis toxin-sensitive GTP-binding protein.
Whooping Cough
Comparison of stimulation by chemotactic formyl peptide analogs between GTPase activity in neutrophil plasma membranes and granule enzyme release from intact neutrophils.
Whooping Cough
Concerted stimulation and deactivation of pertussis toxin-sensitive G proteins by chimeric G protein-coupled receptor-regulator of G protein signaling 4 fusion proteins: analysis of the contribution of palmitoylated cysteine residues to the GAP activity of RGS4.
Whooping Cough
Constitutive activation of NF-kappa B and secretion of interleukin-8 induced by the G protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus involve G alpha(13) and RhoA.
Whooping Cough
Control of the expression and activity of the Galpha-interacting protein (GAIP) in human intestinal cells.
Whooping Cough
Coupling of oxytocin receptor to G proteins in rat myometrium during labor: Gi receptor interaction.
Whooping Cough
Coupling of TGF-beta-induced mitogenesis to G-protein activation in AKR-2B cells.
Whooping Cough
D2 dopamine receptors interact directly with N-type calcium channels and regulate channel surface expression levels.
Whooping Cough
Different domains in the third intracellular loop of the GLP-1 receptor are responsible for Galpha(s) and Galpha(i)/Galpha(o) activation.
Whooping Cough
Different types of ADP-ribose protein bonds formed by botulinum C2 toxin, botulinum ADP-ribosyltransferase C3 and pertussis toxin.
Whooping Cough
Differential activation of Gi and Gs proteins by E- and I-type prostaglandins in membranes from the human erythroleukaemia cell line, HEL.
Whooping Cough
Differential complementation of a Neurospora crassa Galpha(i) mutation using mammalian Galpha protein genes.
Whooping Cough
Differential coupling of muscarinic m2 and m3 receptors to adenylyl cyclases V/VI in smooth muscle. Concurrent M2-mediated inhibition via Galphai3 and m3-mediated stimulation via Gbetagammaq.
Whooping Cough
Differential effects of lovastatin on mitogen induced calcium influx in human cultured vascular smooth muscle cells.
Whooping Cough
Direct activation of purified Go-type GTP binding protein by tricyclic antidepressants.
Whooping Cough
Direct evidence for two distinct G proteins coupling with thrombin receptors in human neuroblastoma SH-EP cells.
Whooping Cough
Direct interactions of mastoparan and compound 48/80 with GTP-binding proteins.
Whooping Cough
Direct modulation of G-proteins by polyunsaturated fatty acids: a novel eicosanoid-independent regulatory mechanism in the developing lung.
Whooping Cough
Distinct cellular expression of pertussis toxin-sensitive GTP-binding proteins in rat cerebellum.
Whooping Cough
Distribution of the alpha-subunit of the guanine nucleotide-binding protein Gi2 and its comparison to G alpha o.
Whooping Cough
Effect of lysophosphatidic acid on motility, polarisation and metabolic burst of human neutrophils.
Whooping Cough
Effect of temperature and host factors on the activities of pertussis toxin and Bordetella adenylate cyclase.
Whooping Cough
Effect of tumor necrosis factor on GTP binding and GTPase activity in HL-60 and L929 cells.
Whooping Cough
Effector coupling of stably transfected human A3 adenosine receptors in CHO cells.
Whooping Cough
Effects of beta-endorphin on mu and delta opioid receptor-coupled G-protein activity: low-Km GTPase studies.
Whooping Cough
Effects of calcium on light-activated GTP-binding proteins in squid photoreceptor membranes.
Whooping Cough
Effects of eosinophils on mast cells: a new pathway for the perpetuation of allergic inflammation.
Whooping Cough
Effects of pertussis toxin-catalyzed ADP-ribosylation on interactions of transducin and the inhibitory GTP-binding protein of adenylate cyclase with guanyl nucleotides.
Whooping Cough
Effects of vasopressin-mastoparan chimeric peptides on insulin release and G-protein activity.
Whooping Cough
Endogenous regulator of G protein signaling proteins suppress Galphao-dependent, mu-opioid agonist-mediated adenylyl cyclase supersensitization.
Whooping Cough
Enhanced cyclic AMP responses in GH3 pituitary cells pretreated with muscarinic receptor agonists.
Whooping Cough
Enhanced detection of receptor constitutive activity in the presence of regulators of G protein signaling: applications to the detection and analysis of inverse agonists and low-efficacy partial agonists.
Whooping Cough
Entamoeba invadens contains the components of a classical adrenergic signaling system.
Whooping Cough
Epidermal growth factor receptor transactivation mediates substance P-induced mitogenic responses in U-373 MG cells.
Whooping Cough
Estrogen mediated inhibition of dopamine transport in the striatum: regulation by G alpha i/o.
Whooping Cough
Evidence for the presence of G-proteins, adenylyl cyclase and phospholipase C activities in lymphatic smooth muscle cell membranes.
Whooping Cough
Evidence for two GTPases activated by thrombin in membranes of human platelets.
Whooping Cough
Evidence that activation of a common G-protein by receptors for leukotriene B4 and N-formylmethionyl-leucyl-phenylalanine in HL-60 cells occurs by different mechanisms.
Whooping Cough
Expression and immunological properties of the five subunits of pertussis toxin.
Whooping Cough
Expression of GTP-binding proteins and protein kinase C isozymes in platelet-like particles derived from megakaryoblastic leukemia cells (MEG-01).
Whooping Cough
Expression of Plasmodium falciparum trimeric G proteins and their involvement in switching to sexual development.
Whooping Cough
Failure of [32P]ADP-ribosylation by pertussis toxin to determine Gi alpha content in membranes from various human tissues. Improved radioimmunological quantification using the 125I-labelled C-terminal decapeptide of retinal transducin.
Whooping Cough
Flow-mediated regulation of G-protein expression in cocultured vascular smooth muscle and endothelial cells.
Whooping Cough
Fluorescent labeling of signal-transducing G-proteins. Pertussis toxin-catalyzed etheno-ADP ribosylation of transducin.
Whooping Cough
Foetal-calf serum stimulates a pertussis-toxin-sensitive high-affinity GTPase activity in rat glioma C6 BU1 cells.
Whooping Cough
Functional alterations of G-proteins in diabetic rat retina: a possible explanation for the early visual abnormalities in diabetes mellitus.
Whooping Cough
Functional coupling of GABA(B) receptors with G proteins that are sensitive to N-ethylmaleimide treatment, suramin, and benzalkonium chloride in rat cerebral cortical membranes.
Whooping Cough
Functional coupling of mu-receptor-Galphai-tethered proteins in AtT20 cells.
Whooping Cough
Functional modifications of transducin induced by cholera or pertussis-toxin-catalyzed ADP-ribosylation.
Whooping Cough
G alpha q/11 mediates cholecystokinin activation of the cationic conductance in rat substantia nigra dopaminergic neurons.
Whooping Cough
G protein beta gamma subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of alpha subunits by pertussis toxin but differential interactions with Gs alpha.
Whooping Cough
G protein beta gamma subunits. Simplified purification and properties of novel isoforms.
Whooping Cough
G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP.
Whooping Cough
G protein expression and second messenger formation in human granulosa cells.
Whooping Cough
G protein signaling from activated rat frizzled-1 to the beta-catenin-Lef-Tcf pathway.
Whooping Cough
G protein-independent G1 cell cycle block and apoptosis with morphine in adenocarcinoma cells: involvement of p53 phosphorylation.
Whooping Cough
G protein-independent stimulation of human myocardial phospholipase C by mastoparan.
Whooping Cough
G proteins in Aplysia: biochemical characterization and regional and subcellular distribution.
Whooping Cough
G-protein betagamma subunit-dependent phosphorylation of 62-kDa protein in the early signaling pathway of starfish oocyte maturation induced by 1-methyladenine.
Whooping Cough
G-protein modulators alter the swimming behavior and calcium influx of Paramecium tetraurelia.
Whooping Cough
GABA(B) receptor-mediated stimulation of adenylyl cyclase activity in membranes of rat olfactory bulb.
Whooping Cough
Galpha12 stimulates c-Jun NH2-terminal kinase through the small G proteins Ras and Rac.
Whooping Cough
Granulocyte-macrophage colony-stimulating factor and human neutrophils: role of guanine nucleotide regulatory proteins.
Whooping Cough
GTP-binding proteins in luminal and basolateral membranes from pars convoluta and pars recta of rabbit kidney proximal tubule.
Whooping Cough
Guanine nucleotide regulation of the pertussis and cholera toxin substrates of rat glioma C6 BU1 cells.
Whooping Cough
Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells.
Whooping Cough
Heterotrimeric G proteins containing G alpha i3 regulate multiple effector enzymes in the same cell. Activation of phospholipases C and A2 and inhibition of adenylyl cyclase.
Whooping Cough
Heterotrimeric Galphaq11 co-immunoprecipitates with surface-anchored GRP78 from plasma membranes of alpha2M*-stimulated macrophages.
Whooping Cough
Hormonal regulation of Gi2 alpha-subunit phosphorylation in intact hepatocytes.
Whooping Cough
Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits.
Whooping Cough
Human 5-HT1A receptor expressed in insect cells activates endogenous G(o)-like G protein(s).
Whooping Cough
Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor.
Whooping Cough
Identification of a protein hydrolysate responsive G protein-coupled receptor in enterocytes.
Whooping Cough
Identification of a second putative receptor of platelet-activating factor from human polymorphonuclear leukocytes.
Whooping Cough
Identification of a structural element in phospholipase C beta2 that interacts with G protein betagamma subunits.
Whooping Cough
Identification of G-proteins in rat parotid gland plasma membranes and granule membranes: presence of distinct components in granule membranes.
Whooping Cough
Identification of guanine nucleotide binding regulatory proteins in bovine tracheal smooth muscle.
Whooping Cough
IgE-Independent Activation of Human Mast Cells Indicates their Role in the Late Phase Reaction of Allergic Inflammation.
Whooping Cough
Immunochemical detection of GTP-binding protein in cephalopod photoreceptors by anti-peptide antibodies.
Whooping Cough
Immunochemical detection of guanine nucleotide binding proteins mono-ADP-ribosylated by bacterial toxins.
Whooping Cough
Immunochemical evidence for a novel pertussis toxin substrate in human neutrophils.
Whooping Cough
Immunological and biochemical differentiation of guanyl nucleotide binding proteins: interaction of Go alpha with rhodopsin, anti-Go alpha polyclonal antibodies, and a monoclonal antibody against transducin alpha subunit and Gi alpha.
Whooping Cough
Immunological characterization of guanine nucleotide-binding proteins: effects of a monoclonal antibody against the gamma subunit of transducin on guanine nucleotide-binding protein-receptor interactions.
Whooping Cough
Improved purification of transducin subunits from bovine retinal rod outer segments.
Whooping Cough
Inhibition by pertussis toxin of guanyl nucleotides exchange on transducin in bovine rod cell membranes.
Whooping Cough
Inhibition of the GTPase activity of transducin by an NAD+:arginine ADP-ribosyltransferase from turkey erythrocytes.
Whooping Cough
Inhibition of voltage-dependent Ca2+ currents and activation of pertussis toxin-sensitive G-proteins via muscarinic receptors in GH3 cells.
Whooping Cough
Interaction of substance P, compound 48/80 and mastoparan with the alpha-subunit C-terminus of G protein.
Whooping Cough
Interactions of the alpha2A-adrenoceptor with multiple Gi-family G-proteins: studies with pertussis toxin-resistant G-protein mutants.
Whooping Cough
Involvement of G protein betagamma-subunits in diverse signaling induced by G(i/o)-coupled receptors: study using the Xenopus oocyte expression system.
Whooping Cough
Involvement of N-myristoylation in monoclonal antibody recognition sites on chimeric G protein alpha subunits.
Whooping Cough
Involvement of signal transducing GTP-binding proteins in renal artery alpha 1-adrenoceptor mediated smooth muscle contraction.
Whooping Cough
Islet-activating protein impairs alpha 2-adrenoceptor-mediated inhibitory regulation of human platelet adenylate cyclase.
Whooping Cough
Islet-activating protein prevents nicotinic acid-induced GTPase stimulation and GTP but not GTP gamma S-induced adenylate cyclase inhibition in rat adipocytes.
Whooping Cough
Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.
Whooping Cough
Kaposi sarcoma-associated herpes virus (KSHV) G protein-coupled receptor (vGPCR) activates the ORF50 lytic switch promoter: a potential positive feedback loop for sustained ORF50 gene expression.
Whooping Cough
Khellin, but not 8-methoxypsoralen, inhibits adenylyl cyclase system in HeLa cells.
Whooping Cough
Leukotriene D4 induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane.
Whooping Cough
Light activation of phosphatidylethanolamine N-methyltransferase in rod outer segments and its modulation by association states of transducin.
Whooping Cough
Light activation of phospholipase A2 in rod outer segments of bovine retina and its modulation by GTP-binding proteins.
Whooping Cough
Lipid modification at the N terminus of photoreceptor G-protein alpha-subunit.
Whooping Cough
Lipophilic beta-adrenoceptor antagonists and local anesthetics are effective direct activators of G-proteins.
Whooping Cough
Localization of a region of the S1 subunit of pertussis toxin required for efficient ADP-ribosyltransferase activity.
Whooping Cough
Luteinizing hormone/choriogonadotropin-dependent, cholera toxin-catalyzed adenosine 5'-diphosphate (ADP)-ribosylation of the long and short forms of Gs alpha and pertussis toxin-catalyzed ADP-ribosylation of Gi alpha*.
Whooping Cough
Lymphocytes in the peritoneum home to the omentum and are activated by resident dendritic cells.
Whooping Cough
Mannose 6-phosphate/insulin-like growth factor II receptor fails to interact with G-proteins. Analysis of mutant cytoplasmic receptor domains.
Whooping Cough
Measurement of agonist efficacy using an alpha2A-adrenoceptor-Gi1alpha fusion protein.
Whooping Cough
Metabotropic glutamate receptor analogues inhibit p[NH]ppG-stimulated phospholipase C activity in bovine brain coated vesicles: involvement of a pertussis toxin-sensitive G-protein.
Whooping Cough
Modification of cysteine residues within G(o) and other neuronal proteins by exposure to nitric oxide.
Whooping Cough
Modification of the amounts of G proteins and of the activity of adenylyl cyclase in human benign thyroid tumours.
Whooping Cough
Modulation of C3a activity: internalization of the human C3a receptor and its inhibition by C5a.
Whooping Cough
Modulation of guanosine triphosphatase activity of G proteins by arachidonic acid in rat Leydig cell membranes.
Whooping Cough
Molecular characterization of the in vitro activation of pertussis toxin by ATP.
Whooping Cough
Molecular cloning and expression of two melanin-concentrating hormone receptors in goldfish.
Whooping Cough
Molecular interaction of the human alpha 2-C10-adrenergic receptor, when expressed in Rat-1 fibroblasts, with multiple pertussis toxin-sensitive guanine nucleotide-binding proteins: studies with site-directed antisera.
Whooping Cough
Mu-type opioid receptors in rat periaqueductal gray-enriched P2 membrane are coupled to guanine nucleotide binding proteins.
Whooping Cough
Muscarinic cholinergic-receptor stimulation of specific GTP hydrolysis related to adenylate cyclase activity in canine cardiac sarcolemma.
Whooping Cough
Mutations of GS alpha designed to alter the reactivity of the protein with bacterial toxins. Substitutions at ARG187 result in loss of GTPase activity.
Whooping Cough
N-Formyl peptide receptor ligation induces rac-dependent actin reorganization through Gbeta gamma subunits and class Ia phosphoinositide 3-kinases.
Whooping Cough
Na+ regulation of formyl peptide receptor-mediated signal transduction in HL 60 cells. Evidence that the cation prevents activation of the G-protein by unoccupied receptors.
Whooping Cough
Neutrophil activation by inflammatory microcrystals of monosodium urate monohydrate utilizes pertussis toxin-insensitive and -sensitive pathways.
Whooping Cough
Nod factors activate both heterotrimeric and monomeric G-proteins in Vigna unguiculata (L.) Walp.
Whooping Cough
Nucleotide exchange and cGMP phosphodiesterase activation by pertussis toxin inactivated transducin.
Whooping Cough
Opioid receptors are coupled tightly to G proteins but loosely to adenylate cyclase in NG108-15 cell membranes.
Whooping Cough
Opposite coupling of prostaglandin E receptor EP3C with Gs and G(o). Stimulation of Gs and inhibition of G(o).
Whooping Cough
Pancreastatin activates pertussis toxin-sensitive guanylate cyclase and pertussis toxin-insensitive phospholipase C in rat liver membranes.
Whooping Cough
Pancreastatin receptor is coupled to a guanosine triphosphate-binding protein of the G(q/11)alpha family in rat liver membranes.
Whooping Cough
Pertussis toxin inhibition of B cell and macrophage responses to bacterial lipopolysaccharide.
Whooping Cough
Pertussis toxin inhibition of chemotaxis and the ADP-ribosylation of a membrane protein in a human-mouse hybrid cell line.
Whooping Cough
Pertussis toxin inhibits induction of human immunodeficiency virus type 1 in infected monocytes.
Whooping Cough
Pertussis toxin reverses the inhibition of the adenylyl cyclase system by khellin in HeLa cells.
Whooping Cough
Pertussis toxin treatment increases glutamate release and dihydropyridine binding sites in cultured rat cerebellar granule neurons.
Whooping Cough
Pertussis toxin-catalyzed ADP-ribosylation of transducin. Cysteine 347 is the ADP-ribose acceptor site.
Whooping Cough
Pharmacological and biochemical characterization of dopamine receptors mediating stimulation of a high affinity GTPase in rat striatum.
Whooping Cough
Platelet activating factor and U44069 stimulate a GTPase activity in human platelets which is distinct from the guanine nucleotide regulatory proteins, Ns and Ni.
Whooping Cough
Platelet activating factor stimulates a receptor-coupled membrane GTPase in guinea pig eosinophils.
Whooping Cough
Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis.
Whooping Cough
Platelet-derived-growth-factor stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: role of pertussis-toxin-sensitive G-proteins, c-Src tyrosine kinases and phosphoinositide 3-kinase.
Whooping Cough
Possible Involvement of Sphingosine-1-Phosphate/G(i)/RhoA Pathways in Adherence of Eosinophils to Pulmonary Endothelium.
Whooping Cough
Preactivation permits subsequent stimulation of phospholipase C by G(i)-coupled receptors.
Whooping Cough
Pregnancy switches adrenergic signal transduction in rat and human uterine myocytes as probed by BKCa channel activity.
Whooping Cough
Primary and secondary structure of bovine retinal S antigen (48-kDa protein).
Whooping Cough
Priming effects of granulocyte-macrophage colony-stimulating factor are coupled to cholera toxin-sensitive guanine nucleotide binding protein in human T lymphocytes.
Whooping Cough
Prolonged activation of extracellular signal-regulated kinase by a protein kinase C-dependent and N17Ras-insensitive mechanism mediates the proliferative response of G(i/o)-coupled somatostatin sst(4) receptors.
Whooping Cough
Properties of a novel GTP-binding protein which is associated with soluble phosphoinositides-specific phospholipase C.
Whooping Cough
Protein-tyrosine phosphatase SHP2 is positively linked to proteinase-activated receptor 2-mediated mitogenic pathway.
Whooping Cough
Purification and characterization of transducin from capybara Hydrochoerus hydrochaeris.
Whooping Cough
Purification and G protein subunit regulation of a phospholipase C-beta from Xenopus laevis oocytes.
Whooping Cough
Purification and properties of the inhibitory guanine nucleotide regulatory unit of brain adenylate cyclase.
Whooping Cough
Quantification of Gi alpha-proteins in the failing and nonfailing human myocardium.
Whooping Cough
Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway.
Whooping Cough
Rat somatostatin receptor type 1 couples to G proteins and inhibition of cyclic AMP accumulation.
Whooping Cough
Reconstitution of the purified porcine atrial muscarinic acetylcholine receptor with purified porcine atrial inhibitory guanine nucleotide binding protein.
Whooping Cough
Reduction of adenylyl cyclase activity by cholera toxin in myeloid cells. Long-term down-regulation of Gs alpha subunits by cholera toxin treatment.
Whooping Cough
Regulation of G protein activation and effector modulation by fusion proteins between the human 5-hydroxytryptamine(1A) receptor and the alpha subunit of G(i1): differences in receptor-constitutive activity imparted by single amino acid substitutions in G(i1)alpha.
Whooping Cough
Regulation of GTPase and adenylate cyclase activity by amyloid beta-peptide and its fragments in rat brain tissue.
Whooping Cough
Regulation of human interleukin-8 receptor A: identification of a phosphorylation site involved in modulating receptor functions.
Whooping Cough
Regulation of retinal cGMP cascade by phosducin in bovine rod photoreceptor cells. Interaction of phosducin and transducin.
Whooping Cough
Requirement of Gbetagamma and c-Src in D2 dopamine receptor-mediated nuclear factor-kappaB activation.
Whooping Cough
Requirement of phosphatidylinositol 3-kinase activity for bradykinin stimulation of NF-kappaB activation in cultured human epithelial cells.
Whooping Cough
Role of altered G-protein expression in the regulation of myocardial adenylate cyclase activity and force of contraction in spontaneous hypertensive cardiomyopathy in rats.
Whooping Cough
Role of carboxylmethylation in chemoattractant receptor-stimulated G protein activation and functional responses.
Whooping Cough
Role of G protein beta gamma subunits in the regulation of the plasma membrane Ca2+ pump.
Whooping Cough
Role of guanine nucleotide regulatory proteins and inositol phosphates in the hormone induced mobilization of hepatocyte calcium.
Whooping Cough
Role of histidine 35 of the S1 subunit of pertussis toxin in the ADP-ribosylation of transducin.
Whooping Cough
Roles of heterotrimeric and monomeric G proteins in sperm-induced activation of mouse eggs.
Whooping Cough
Secretion-stimulating and secretion-inhibiting hormones stimulate high-affinity pertussis-toxin-sensitive GTPases in membranes of a pituitary cell line.
Whooping Cough
Selective reconstitution of gastrin-releasing peptide receptor with G alpha q.
Whooping Cough
Signal-dependent translocation of transducin, RGS9-1-Gbeta5L complex, and arrestin to detergent-resistant membrane rafts in photoreceptors.
Whooping Cough
Solubilization of the vasopressin receptor from rat liver plasma membranes. Evidence for a receptor X GTP-binding protein complex.
Whooping Cough
Sphingosine 1-phosphate stimulates G(i)- and Rho-mediated vascular endothelial cell spreading and migration.
Whooping Cough
Sphingosine-1-phosphate-induced oxygen free radical generation in smooth muscle cell migration requires Galpha12/13 protein-mediated phospholipase C activation.
Whooping Cough
Spontaneous association between opioid receptors and GTP-binding regulatory proteins in native membranes: specific regulation by antagonists and sodium ions.
Whooping Cough
Stimulation of phospholipase A2 activity in bovine rod outer segments by the beta gamma subunits of transducin and its inhibition by the alpha subunit.
Whooping Cough
Stimulation of the T-cell receptors CD3 and CD2 with OKT3 and OKT11 antibodies activates a common pertussis toxin-insensitive G-protein.
Whooping Cough
Stimulation of the thiol-dependent ADP-ribosyltransferase and NAD glycohydrolase activities of Bordetella pertussis toxin by adenine nucleotides, phospholipids, and detergents.
Whooping Cough
Stimulatory and inhibitory guanine-nucleotide-binding regulatory protein involvement in stimulation of arachidonic-acid release by N-formyl-methionyl-leucyl-phenylalanine and platelet-activating factor from guinea-pig alveolar macrophages. Differential receptor/G-protein interaction assessed by pertussis and cholera toxins.
Whooping Cough
Stromal cell-derived factor-1-induced LFA-1 activation during in vivo migration of T cell hybridoma cells requires Gq/11, RhoA, and myosin, as well as Gi and Cdc42.
Whooping Cough
Structural and functional relationships of guanosine triphosphate binding proteins.
Whooping Cough
Structural requirements for G(o) activation by receptor-derived peptides: activation and modulation domains of the alpha 2-adrenergic receptor i3c region.
Whooping Cough
Study of the phorbol ester effect on Alzheimer amyloid precursor processing: sequence requirements and involvement of a cholera toxin sensitive protein.
Whooping Cough
Subcellular localization and kinetic characterization of guanine nucleotide binding proteins in normal rat and human pancreatic islets and transformed beta cells.
Whooping Cough
Supersensitivity to mu-opioid receptor-mediated inhibition of the adenylyl cyclase pathway involves pertussis toxin-resistant Galpha protein subunits.
Whooping Cough
Suppression of cyclic GMP-dependent protein kinase is essential to the Wnt/cGMP/Ca2+ pathway.
Whooping Cough
Synthesis and characterization of fluorescently labeled bovine brain G protein subunits.
Whooping Cough
The alpha subunit of Gq contributes to muscarinic inhibition of the M-type potassium current in sympathetic neurons.
Whooping Cough
The beta6/alpha5 regions of Galphai2 and GalphaoA increase the promiscuity of Galpha16 but are insufficient for pertussis toxin-catalyzed ADP-ribosylation.
Whooping Cough
The Ca2+-dependent binding of calmodulin to an N-terminal motif of the heterotrimeric G protein beta subunit.
Whooping Cough
The Ca2+-sensing receptor couples to Galpha12/13 to activate phospholipase D in Madin-Darby canine kidney cells.
Whooping Cough
The carboxyl terminus of the S1 subunit of pertussis toxin confers high affinity binding to transducin.
Whooping Cough
The D2-dopamine receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein.
Whooping Cough
The function but not the expression of rat liver inhibitory guanine nucleotide binding protein is altered in streptozotocin-induced diabetes.
Whooping Cough
The G protein beta gamma subunit transduces the muscarinic receptor signal for Ca2+ release in Xenopus oocytes.
Whooping Cough
The G proteins of the G alpha i and G alpha q family couple the bradykinin receptor to the release of endothelium-derived relaxing factor.
Whooping Cough
The glutamate-receptor linked cGMP cascade of retinal on-bipolar cells is pertussis and cholera toxin-sensitive.
Whooping Cough
The guanine-nucleotide-binding protein subunit G alpha i2 is involved in calcium activation of phospholipase A2. Effects of the dominant negative G alpha i2 mutant, [G203T]G alpha i2, on activation of phospholipase A2 in Chinese hamster ovary cells.
Whooping Cough
The heterotrimeric G protein G alpha i2 mediates lysophosphatidic acid-stimulated induction of the c-fos gene in mouse fibroblasts.
Whooping Cough
The heterotrimeric G-protein Gi is localized to the insulin secretory granules of beta-cells and is involved in insulin exocytosis.
Whooping Cough
The human S100 protein MRP-14 is a novel activator of the beta 2 integrin Mac-1 on neutrophils.
Whooping Cough
The inhibition of neutrophil granule enzyme secretion and chemotaxis by pertussis toxin.
Whooping Cough
The kyotorphin (tyrosine-arginine) receptor and a selective reconstitution with purified Gi, measured with GTPase and phospholipase C assays.
Whooping Cough
The presence of a heterotrimeric G protein and its role in signal transduction of extracellular calmodulin in pollen germination and tube growth
Whooping Cough
The purification of a guanine nucleotide regulatory protein from rat brain membrane and the measurement of its GTPase.
Whooping Cough
The regulator of G protein signaling RGS4 selectively enhances alpha 2A-adreoreceptor stimulation of the GTPase activity of Go1alpha and Gi2alpha.
Whooping Cough
Thrombin inhibits Bim (Bcl-2-interacting mediator of cell death) expression and prevents serum-withdrawal-induced apoptosis via protease-activated receptor 1.
Whooping Cough
Thrombin receptor activation by thrombin and receptor-derived peptides in platelet and CHRF-288 cell membranes: receptor-stimulated GTPase and evaluation of agonists and partial agonists.
Whooping Cough
Thrombin stimulates pertussis toxin-sensitive and -insensitive GTPase activities and ADP-ribosylation of G(i) in human neuroblastoma SH-EP.
Whooping Cough
Thrombin, unlike vasopressin, appears to stimulate two distinct guanine nucleotide regulatory proteins in human platelets.
Whooping Cough
Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3.
Whooping Cough
Thy-1 antibody-triggered neurite outgrowth requires an influx of calcium into neurons via N- and L-type calcium channels.
Whooping Cough
Toll-like receptor 4 coupled GI protein signaling pathways regulate extracellular signal-regulated kinase phosphorylation and AP-1 activation independent of NFkappaB activation.
Whooping Cough
Transforming growth factor beta 1 treatment of AKR-2B cells is coupled through a pertussis-toxin-sensitive G-protein(s).
Whooping Cough
Treatment of rabbit neutrophils with phorbol esters results in increased ADP-ribosylation catalyzed by pertussis toxin and inhibition of the GTPase stimulated by fMet-Leu-Phe.
Whooping Cough
Two mechanisms of photoendocrine transduction in cultured chick pineal cells: pertussis toxin blocks the acute but not the phase-shifting effects of light on the melatonin rhythm.
Whooping Cough
Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein.
Whooping Cough
VIP inhibits N-type Ca2+ channels of sympathetic neurons via a pertussis toxin-insensitive but cholera toxin-sensitive pathway.
Whooping Cough
[Effect of bacterial toxins on the GTPase activity of transducin from bovine rod outer segments]
Whooping Cough
[Effects of G-Protein Regulators and Stylar S-RNase on the Growth and Ca(2+) Concentration of Pyrus pyrifolia Pollen Tube.]
Whooping Cough
[Identification and isolation of GTP-binding regulator protein from plasma membranes of oocytes from the starfish Asterias amurensis]
Whooping Cough
[Inhibitory effect of pertussis toxin on the metabolism of guanine nucleotides in transducin from bovine outer rod segments]
Whooping Cough
[The effect of G protein regulator on pollen germination and [Ca2+]i variation in Pyrus serotina Rehd. pollen.]
Wilms Tumor
Carbonic anhydrase IV inhibits colon cancer development by inhibiting the Wnt signalling pathway through targeting the WTAP-WT1-TBL1 axis.
Wiskott-Aldrich Syndrome
An NGF-induced Exo70-TC10 complex locally antagonises Cdc42-mediated activation of N-WASP to modulate neurite outgrowth.
Wiskott-Aldrich Syndrome
Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein.
Wiskott-Aldrich Syndrome
Coiling phagocytosis of Borrelia burgdorferi by primary human macrophages is controlled by CDC42Hs and Rac1 and involves recruitment of Wiskott-Aldrich syndrome protein and Arp2/3 complex.
Wiskott-Aldrich Syndrome
Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP.
Wiskott-Aldrich Syndrome
Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42.
Wiskott-Aldrich Syndrome
EFC/F-BAR proteins and the N-WASP-WIP complex induce membrane curvature-dependent actin polymerization.
Wiskott-Aldrich Syndrome
Fluorescence approaches for monitoring interactions of Rho GTPases with nucleotides, regulators, and effectors.
Wiskott-Aldrich Syndrome
Genetically encoded photoswitching of actin assembly through the Cdc42-WASP-Arp2/3 complex pathway.
Wiskott-Aldrich Syndrome
Global disruption of the WASP autoinhibited structure on Cdc42 binding. Ligand displacement as a novel method for monitoring amide hydrogen exchange.
Wiskott-Aldrich Syndrome
Lassa Virus Cell Entry via Dystroglycan Involves an Unusual Pathway of Macropinocytosis.
Wiskott-Aldrich Syndrome
Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP.
Wiskott-Aldrich Syndrome
SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site.
Wiskott-Aldrich Syndrome
The dock-and-coalesce mechanism for the association of a WASP disordered region with the Cdc42 GTPase.
Wiskott-Aldrich Syndrome
The interaction between Cdc42 and WASP is required for SDF-1-induced T-lymphocyte chemotaxis.
Wiskott-Aldrich Syndrome
The nucleotide switch in Cdc42 modulates coupling between the GTPase-binding and allosteric equilibria of Wiskott-Aldrich syndrome protein.
Wiskott-Aldrich Syndrome
Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome.
Wiskott-Aldrich Syndrome
WIP participates in actin reorganization and ruffle formation induced by PDGF.
Wiskott-Aldrich Syndrome
Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
additional information
-
the relative levels of the G-protein alpha subunits GS alpha-L, GS alpha-S, Gialpha-1, Gialpha-2 and Goalpha are unchanged in membranes prepared from Alzheimer-diseased frontal cortex or hippocampus to control brains. The activity of the G-protein associated high affinity GTPase is reduced in the frontal cortex by 25% and in the hippocampus by 27%
brenda
additional information
-
both Galpha12 and Galpha13 are expressed ubiquitously
brenda
additional information
no enzyme expression in H-2122 , A-549, H-661, and H-1299 cancer cells, quantitaative enzyme expression analysis, overview
brenda
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
evolution
-
Galpha subunits are classified into four subfamilies, Gs, Gi, Gq and G12. Galpha12/13 and Galphaq are directly involved in the activation of RhoGTPases, molecular mechanisms for regulation of RhoGTPase activity through GPCR heterotrimeric G12/13-signalling pathways, overview. The G12/13-RH-RhoGEF signalling mechanism is well conserved over species
malfunction
-
overexpression of constitutively active Galpha12 or 13 induces several cellular effects which suggest stimulation of Rho activity in cells, such as formation of actin stress fibres or neurite retraction in neuronal cells. NIH3T3 transforming activity of constitutively active mutant of Galpha12 can be prevented by blocking its palmitoylation
metabolism
-
Rho guanine nucleotide exchange factor p63RhoGEF619 relocates to the plasma membrane upon activation of Galphaq coupled GPCRs, resembling the well-known activation mechanism of Rho guanine nucleotide exchange factors (RhoGEFs) activated by Galpha12/13. Synthetic recruitment of p63RhoGEF619 to the plasma membrane increases RhoGEF activity towards GTPase RhoA, but full activation requires allosteric activation via Galphaq, overview. Dual role for heterotrimeric G-protein Galphaq in RhoGEF activation, as it both recruits and allosterically activates cytosolic ARHGEF25 gene encoding three RhoGEF isoforms. Activation of the heterotrimeric G-protein Galphaq relieves the DH domain of p63RhoGEF from its autoinhibited state by allosteric interaction with the PH domain
physiological function
additional information
-
Gbetagamma interacts with the N-terminal alpha helix of Galpha through one of the seven bladed propellers of the Gbeta subunit
physiological function
-
the G12/13-RH-RhoGEF signalling mechanism is involved in critical steps for cell physiology and disease conditions, including embryonic development, oncogenesis and cancer metastasis. alpha Subunits of G12 or G13 interact with members of the RH domain containing guanine nucleotide exchange factors for Rho (RH-RhoGEF) family of proteins to directly connect G protein-mediated signalling and RhoGTPase signalling, G12/13-mediated signalling is one mechanism to regulate RhoGTPase activity in response to extracellular stimuli. Wild-type Galpha12 is the only Galpha subunit that acts as an oncogene in NIH3T3 cells
physiological function
G-protein, Galpha16, is a critical downstream effector of non-canonical Wnt signaling and a potent inhibitor of transformed cell growth in non small cell lung cancer, Wnt7a-stimulated ERK5 activation is Galpha16-dependent. Importance of Wnt7a signaling via its cognate receptor Frizzled9, a G-protein-coupled receptor, in inhibition of cell proliferation, anchorage-independent growth, and reversal of transformed phenotype in non small cell lung cancer primarily through activation of the tumor suppressor, PPARgamma. Galpha16 is a regulator of non small cell lung cancer cell proliferation and anchorage-independent cell growth. Galpha16 and Galphaq are important mediators of PPARgamma and E-cadherin expression in non small cell lung cancer cell lines
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PDB
SCOP
CATH
UNIPROT
ORGANISM
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
heterotrimer
additional information
heterotrimer
-
Galpha subunit, GDP-bound inactive, GTP-bound active and betagamma dimer
additional information
-
G36 with a MW of 36000 Da determined by SDS-PAGE can be Gialpha or Goalpha. G50 with a MW of 50000 Da determined by SDS-PAGE can be Gsalpha
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POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
lipoprotein
-
both Galpha12 and 13 are subjected to palmitoylation at cysteine residues near their N-terminus, palmitoylation of Galpha13 is required for its association with the plasma membrane and its ability to activate RhoA through p115RhoGEF. Palmitoylated Galpha12 but not Galpha13 localizes in lipid rafts
phosphoprotein
-
phosphorylation of Galpha subunits is an important modification that regulates their function. Galpha12 is a substrate for phosphorylation by protein kinase C. Endogenous Ga12 in human platelets is phosphorylated within the first 50 N-terminal amino acid residues in response to PMA, thrombin and the TXA2 receptor agonist U46619. Phosphorylated Galpha12 loses its affinity for Gbetagamma, and the association with Gbetagamma reciprocally inhibits the phosphorylation of Ga12 by protein kinase C. Endogenous Galpha13 in platelets is phosphorylated in response to PMA, although not in vitro. PKC-mediated phosphorylation of Ga13 in cell might require additional factors
side-chain modification
additional information
-
Galpha12 and Galpha13 are not myristoylated because they lack a glycine residue as the second amino acid residue
side-chain modification
-
betagamma subunit can be phosphorylated on His residues
side-chain modification
-
protein kinase K-like kinase phosphorylates G36 protein. The phosphorylation of G36 increases its Km for GTP by about 8fold without modification of Vmax. No significant modification after phosphorylation of G50 by protein kinase C or cAMP kinase
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
CFP-TM-Galpha
-
consists of a cleavable signal peptide from human growth hormone, enhanced CFP, the amino-terminal amino acids of the rat mu-opioid receptor, including TM1 and intracellular loop1, and the human Galpha subunit
CFP-TM-Galphai3
-
C to G mutation at the -4 position to render them insensitive to PTX-mediated ADP-ribosylation
CFP-TM-GalphaoA
-
C to G mutation at the -4 position to render them insensitive to PTX-mediated ADP-ribosylation
CFP-TM-Galphasq5
-
the five aminoacids normally found in the carboxyl terminus of Galphas, QYELL, are replaced with those normally found in the carboxy terminus of Galphaq, EYNLV
R238E
-
mutant, reported to be a dominant-negative inhibitor of the rhodopsin-transducin-PDE visual system
S111N
-
mutation at carboxy-terminal end of helix alpha of helical domain, decreased nucleotide exchange kinetics, impaired adenylyl cyclase activation with GTPgammaS, but normal receptor and AlF4- activation
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
Gtalpha and GtalphaR238E for expression in Escherichia coli strains DH5alpha and BL21(DE3)
-
overexpression of heterotrimeric G-proteins Galphai1 and Galphai3 in Spodoptera frugiperda Sf 9 cell membranes using the baculovirus transfection method
-
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
drug development
-
mutants of transducin represent a major tool in designing potential therapeutical strategies for a group of visual diseases
medicine
medicine
-
mutations in the gene for the alpha-subunit of cone transducin, GNAT2, cause cone-rod degeneration, CRD
medicine
the enzyme is important as a potential therapeutic target for the treatment of non small cell lung cancer
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Natochin, M.; Granovsky, A.E.; Artemyev, N.O.
Regulation of transducin GTPase activity by human retinal RGS
J. Biol. Chem.
272
17444-17449
1997
Homo sapiens
brenda
Ueda, H.; Misawa, H.; Katada, T.; Ui, M.; Takagi, H.; Satoh, M.
Functional reconstitution of purified Gi and Go with mue-opioid receptors in guinea pig striatal membranes pretreated with micromolar concentrations of N-ethylmaleimide
J. Neurochem.
54
841-848
1990
Bos taurus, Homo sapiens, Sus scrofa
brenda
Rouot, B.; Brabet, P.; Homburger, V.; Toutant, M.; Bockaert, J.
Go, a major brain GTP binding protein in search of a function: purification, immunological and biochemical characteristics
Biochimie
69
339-349
1987
Bos taurus, Canis lupus familiaris, Gallus gallus, Homo sapiens, Rattus norvegicus
brenda
Ross, B.M.; McLaughlin, M.; Roberts, M.; Milligan, G.; McCulloch, J.; Knowler, J.T.
Alterations in the activity of adenylate cyclase and high affinity GTPase in Alzheimer's disease
Brain Res.
622
35-42
1993
Homo sapiens
brenda
Sauvage, C.; Rumigny, J.F.; Maitre, M.
Purification and characterization of G proteins from human brain: modification of GTPase activity upon phosphorylation
Mol. Cell. Biochem.
107
65-77
1991
Homo sapiens
brenda
Neer, E.J.
Heterotrimeric G proteins: organizers of transmembrane signals
Cell
80
249-257
1995
Homo sapiens, Mammalia
brenda
Park, I.K.; Klug, C.A.; Li, K.; Jerabek, L.; Li, L.; Nanamori, M.; Neubig, R.R.; Hood, L.; Weissman, I.L.; Clarke, M.F.
Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells
J. Biol. Chem.
276
915-923
2001
Homo sapiens
brenda
Brito, M.; Guzman, L.; Romo, X.; Soto, X.; Hinrichs, M.V.; Olate, J.
S111N mutation in the helical domain of human Gs(alpha) reduces its GDP/GTP exchange rate
J. Cell. Biochem.
85
615-620
2002
Homo sapiens
brenda
Siderovski, D.P.; Willard, F.S.
The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits
Int. J. Biol. Sci.
1
51-66
2005
Aspergillus nidulans, Saccharomyces cerevisiae, Caenorhabditis elegans, Homo sapiens
brenda
Barren, B.; Natochin, M.; Artemyev, N.O.
Mutation R238E in transducin-alpha yields a GTPase and effector-deficient, but not dominant-negative, G-protein alpha-subunit
Mol. Vis.
12
492-498
2006
Homo sapiens
brenda
Pina, A.L.; Baumert, U.; Loyer, M.; Koenekoop, R.K.
A three base pair deletion encoding the amino acid (lysine-270) in the alpha-cone transducin gene
Mol. Vis.
10
265-271
2004
Homo sapiens
brenda
Digby, G.J.; Lober, R.M.; Sethi, P.R.; Lambert, N.A.
Some G protein heterotrimers physically dissociate in living cells
Proc. Natl. Acad. Sci. USA
21
17789-17794
2006
Homo sapiens
brenda
Preuss, I.; Kurig, B.; Nuernberg, B.; Orth, J.H.; Aktories, K.
Pasteurella multocida toxin activates Gbetagamma dimers of heterotrimeric G proteins
Cell. Signal.
21
551-558
2009
Homo sapiens, Mus musculus
brenda
Dave, R.H.; Saengsawang, W.; Yu, J.Z.; Donati, R.; Rasenick, M.M.
Heterotrimeric G-proteins interact directly with cytoskeletal components to modify microtubule-dependent cellular processes
Neurosignals
17
100-108
2009
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Orth, J.H.; Preuss, I.; Fester, I.; Schlosser, A.; Wilson, B.A.; Aktories, K.
Pasteurella multocida toxin activation of heterotrimeric G proteins by deamidation
Proc. Natl. Acad. Sci. USA
106
7179-7184
2009
Homo sapiens, Mus musculus
brenda
Kozasa, T.; Hajicek, N.; Chow, C.R.; Suzuki, N.
Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13
J. Biochem.
150
357-369
2011
Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens
brenda
Zhao, P.; Nunn, C.; Ramineni, S.; Hepler, J.R.; Chidiac, P.
The Ras-binding domain region of RGS14 regulates its functional interactions with heterotrimeric G proteins
J. Cell. Biochem.
114
1414-1423
2013
Homo sapiens
brenda
Avasarala, S.; Bikkavilli, R.K.; Van Scoyk, M.; Zhang, W.; Lapite, A.; Hostetter, L.; Byers, J.T.; Heasley, L.E.; Sohn, J.W.; Winn, R.A.
Heterotrimeric G-protein, Galpha16, is a critical downstream effector of non-canonical Wnt signaling and a potent inhibitor of transformed cell growth in non small cell lung cancer
PLoS ONE
8
e76895
2013
Homo sapiens (P30679)
brenda
van Unen, J.; Yin, T.; Wu, Y.I.; Mastop, M.; Gadella, T.W.; Goedhart, J.
Kinetics of recruitment and allosteric activation of ARHGEF25 isoforms by the heterotrimeric G-protein Galphaq
Sci. Rep.
6
36825
2016
Homo sapiens
brenda
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Release 2023.1 (January 2023)
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