Information on EC 3.6.5.1 - heterotrimeric G-protein GTPase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Mark a special word or phrase in this record:
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY
3.6.5.1
-
RECOMMENDED NAME
GeneOntology No.
heterotrimeric G-protein GTPase
PATHWAY
KEGG Link
MetaCyc Link
NIL
-
SYSTEMATIC NAME
IUBMB Comments
GTP phosphohydrolase (signalling)
This group comprises GTP-hydrolysing systems, where GTP and GDP alternate in binding. This group includes stimulatory and inhibitory G-proteins such as Gs, Gi, Go and Golf, targetting adenylate cyclase and/or K+ and Ca2+ channels; Gq stimulating phospholipase C; transducin activating cGMP phosphodiesterase; gustducin activating cAMP phosphodiesterase. Golf is instrumental in odour perception, transducin in vision and gustducin in taste recognition. At least 16 different alpha subunits (39-52 kDa), 5 beta subunits (36 kDa) and 12 gamma subunits (6-9 kDa) are known.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
cone transducin
-
-
EC 3.6.1.46
-
-
formerly
-
elongation factor 2
-
-
G alpha i2
-
-
G alpha q
-
-
G alpha11
-
-
G alphaQ
-
-
G betagamma
-
-
Galpha-subunit
Saccharomyces pombe
-
-
GPA1
Saccharomyces pombe
-
-
Gs alpha
-
-
GTP phosphohydrolase
-
-
-
-
GTP phosphohydrolase
-
-
GTP phosphohydrolase
-
-
GTP phosphohydrolase
-
-
GTP phosphohydrolase
-
-
GTP phosphohydrolase
-
-
GTP phosphohydrolase
-
-
GTPase
-
-
-
-
guanosine 5'-triphosphatase
-
-
-
-
guanosine triphosphatase
-
-
-
-
heterotrimeric G protein
-
-
heterotrimeric G protein
-
-
heterotrimeric G protein
Saccharomyces pombe
-
-
heterotrimeric G protein alpha subunit
-
-
heterotrimeric G protein family
-
-
heterotrimeric G protein Gsalpha
P63091
-
heterotrimeric G-protein
-
-
heterotrimeric G-protein
-
-
heterotrimeric G-protein GTPase
-
-
heterotrimeric G-protein GTPase
-
-
heterotrimeric G-protein GTPase
-
-
heterotrimeric G-protein GTPase
-
-
heterotrimeric G-protein GTPase
-
-
heterotrimeric G-protein GTPase
-
-
heterotrimeric G-protein GTPase
-
-
heterotrimeric G-protein GTPase
-
-
heterotrimeric GTPase
-
-
heterotrimeric GTPase
-
-
phosphatase, guanosine tri-
-
-
-
-
photoreceptor-specific G protein
-
-
Rab1
-
-
Rab1 GTPase
-
-
Rab1a
-
there are two isoforms, Rab1a and Rab1b
ribosomal GTPase
-
-
-
-
transducin
-
-
transducin
-
-
transducin GTPase
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
9059-32-9
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
a mixture of trimeric Gq and G11, referred to as Gq/11
-
-
Manually annotated by BRENDA team
alpha-subunit of transducin
-
-
Manually annotated by BRENDA team
Go and Gs
-
-
Manually annotated by BRENDA team
Go: a G protein with unknown function
-
-
Manually annotated by BRENDA team
Goalpha
-
-
Manually annotated by BRENDA team
photoreceptor G protein transducin
-
-
Manually annotated by BRENDA team
taste-specific G protein, gustducin
-
-
Manually annotated by BRENDA team
Aspergillus Emericella nidulans
-
-
Manually annotated by BRENDA team
cv. Jack Seeds
-
-
Manually annotated by BRENDA team
cv. Jack Seeds, four soybean Galpha proteins GmGalpha1-4
-
-
Manually annotated by BRENDA team
transducin GTPase activity
-
-
Manually annotated by BRENDA team
recombiant protein expressed in Escherichia coli
-
-
Manually annotated by BRENDA team
alpha subunit of transducin
-
-
Manually annotated by BRENDA team
alpha subunit of transducin
-
-
Manually annotated by BRENDA team
Gi1alpha, Gi2alpha anf Gi3alpha
-
-
Manually annotated by BRENDA team
Gialpha1
-
-
Manually annotated by BRENDA team
Sprague-Dawley rat
-
-
Manually annotated by BRENDA team
Rattus norvegicus Gialpha1
Gialpha1
-
-
Manually annotated by BRENDA team
Saccharomyces pombe
-
-
-
Manually annotated by BRENDA team
recombinant protein expressed in baculovirus/Sf9 system, reconstituted in vesicles
-
-
Manually annotated by BRENDA team
Gi: the G protein that mediates inhibition of adenylate cyclase
-
-
Manually annotated by BRENDA team
GTPase that functions as a component of the rhodopsin-linked, light-activated phosphodiesterase system
-
-
Manually annotated by BRENDA team
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Mg2+
-
-
Mg2+
-
required
SPECIFIC ACTIVITY [µmol/min/mg]
SPECIFIC ACTIVITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
0.722
-
-
recombinant GL2
TEMPERATURE RANGE
TEMPERATURE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
22
24
-
activity assay