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Adenocarcinoma of Lung
MiR-145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1.
Adenoma
Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3.
Astrocytoma
Expression analyses of 27 DNA repair genes in astrocytoma by TaqMan low-density array.
Breast Neoplasms
Cellular 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity of human and mouse MTH1 proteins does not depend on the proliferation rate.
Breast Neoplasms
Enhanced expression of the 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase gene in human breast tumor cells.
Breast Neoplasms
Expression and function of MutT homolog 1 in distinct subtypes of breast cancer.
Carcinogenesis
A novel assay of 8-oxo-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase (8-oxo-dGTPase) activity in cultured cells and its use for evaluation of cadmium(II) inhibition of this activity.
Carcinogenesis
A profile of 8-oxo-dGTPase activities in the NCI-60 human cancer panel: Meta-analytic insight into the regulation and role of MTH1 (NUDT1) gene expression in carcinogenesis.
Carcinogenesis
Cadmium(II), unlike nickel(II), inhibits 8-oxo-dGTPase activity and increases 8-oxo-dG level in DNA of the rat testis, a target organ for cadmium(II) carcinogenesis.
Carcinogenesis
cDNA and genomic sequences for rat 8-oxo-dGTPase that prevents occurrence of spontaneous mutations due to oxidation of guanine nucleotides.
Carcinogenesis
Cellular levels of 8-oxoguanine in either DNA or the nucleotide pool play pivotal roles in carcinogenesis and survival of cancer cells.
Carcinogenesis
Induction of 8-oxo-dGTPase activity in human lymphoid cells and normal fibroblasts by oxidative stress.
Carcinogenesis
Inhibition of antimutagenic enzymes, 8-oxo-dGTPases, by carcinogenic metals. Recent developments.
Carcinogenesis
Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase.
Carcinogenesis
The role of miR-485-5p/NUDT1 axis in gastric cancer.
Carcinoma
MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways.
Carcinoma
NUDT1: A potential independent predictor for the prognosis of patients with oral squamous cell carcinoma.
Carcinoma, Ductal
Enhanced expression of the 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase gene in human breast tumor cells.
Colorectal Neoplasms
Analysis of the Oxidative Damage Repair Genes NUDT1, OGG1, and MUTYH in Patients from Mismatch Repair Proficient HNPCC Families (MSS-HNPCC).
Colorectal Neoplasms
Germline variation in the oxidative DNA repair genes NUDT1 and OGG1 is not associated with hereditary colorectal cancer or polyposis.
Colorectal Neoplasms
Polymorphisms of DNA repair genes are associated with colorectal cancer in patients with Lynch syndrome.
Colorectal Neoplasms, Hereditary Nonpolyposis
Polymorphisms of DNA repair genes are associated with colorectal cancer in patients with Lynch syndrome.
Glioblastoma
MutT homolog 1 counteracts the effect of anti-neoplastic treatments in adult and pediatric glioblastoma cells.
Heart Failure
8-oxo-dGTPase, which prevents oxidative stress-induced DNA damage, increases in the mitochondria from failing hearts.
Hypertension
In Defense of the Nucleus: NUDT1 and Oxidative DNA Damage in Pulmonary Arterial Hypertension.
Hypertension
Oxidized DNA Precursors Cleanup by NUDT1 Contributes to Vascular Remodeling in Pulmonary Arterial Hypertension.
Leukemia
Cellular 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity of human and mouse MTH1 proteins does not depend on the proliferation rate.
Leukemia, T-Cell
Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria.
Lung Neoplasms
Influence of Chirality of Crizotinib on Its MTH1 Protein Inhibitory Activity: Insight from Molecular Dynamics Simulations and Binding Free Energy Calculations.
Lung Neoplasms
Integrative genomic and gene expression analysis of chromosome 7 identified novel oncogene loci in non-small cell lung cancer.
Melanoma
Cellular 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity of human and mouse MTH1 proteins does not depend on the proliferation rate.
Multiple Myeloma
Human MutT homologue 1 mRNA overexpression correlates to poor response of multiple myeloma.
Multiple Myeloma
[Proliferation-Inhibitory and Apoptosis-Inducing Effects of Targeting MTH1 on Multiple Myeloma Cells].
Neoplasm Metastasis
The role of miR-485-5p/NUDT1 axis in gastric cancer.
Neoplasms
A Double-Edged Sword: The Anti-Cancer Effects of Emodin by Inhibiting the Redox-Protective Protein MTH1 and Augmenting ROS in NSCLC.
Neoplasms
A profile of 8-oxo-dGTPase activities in the NCI-60 human cancer panel: Meta-analytic insight into the regulation and role of MTH1 (NUDT1) gene expression in carcinogenesis.
Neoplasms
Antitumor effects of MutT homolog 1 inhibitors in human bladder cancer cells.
Neoplasms
Augment of Oxidative Damage with Enhanced Photodynamic Process and MTH1 Inhibition for Tumor Therapy.
Neoplasms
Cellular 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity of human and mouse MTH1 proteins does not depend on the proliferation rate.
Neoplasms
Dual Inhibitors of 8-Oxoguanine Surveillance by OGG1 and NUDT1.
Neoplasms
Enhanced expression of the 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase gene in human breast tumor cells.
Neoplasms
Expression and function of MutT homolog 1 in distinct subtypes of breast cancer.
Neoplasms
Investigation of MTH1 activity via mismatch-based DNA chain elongation.
Neoplasms
Ligand retargeting by binding site analogy.
Neoplasms
Mechanisms of MTH1 inhibition-induced DNA strand breaks: The slippery slope from the oxidized nucleotide pool to genotoxic damage.
Neoplasms
Nudix hydrolase 1 is a prognostic biomarker in hepatocellular carcinoma.
Neoplasms
NUDT1: A potential independent predictor for the prognosis of patients with oral squamous cell carcinoma.
Neoplasms
Oxidized DNA Precursors Cleanup by NUDT1 Contributes to Vascular Remodeling in Pulmonary Arterial Hypertension.
Neoplasms
Protective effect of Yiguanjian decoction against DNA damage on concanavalin A-induced liver injury mice model.
Neoplasms
Radiolabeled 6-(2, 3-Dichlorophenyl)-N4-methylpyrimidine-2, 4-diamine (TH287): A Potential Radiotracer for Measuring and Imaging MTH1.
Neoplasms
Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity.
Neoplasms
Synergistic therapy of chemotherapeutic drugs and MTH1 inhibitors using a pH-sensitive polymeric delivery system for oral squamous cell carcinoma.
Neoplasms
Targeting DNA repair, DNA metabolism and replication stress as anti-cancer strategies.
Neoplasms
Targeting human MutT homolog 1 (MTH1) for cancer eradication: current progress and perspectives.
Neoplasms
TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model.
Neoplasms
The role of miR-485-5p/NUDT1 axis in gastric cancer.
Neoplasms
The Search for Molecular Markers in a Gene-Orphan Case Study of a Pediatric Spinal Cord Pilocytic Astrocytoma.
Osteosarcoma
Delivery of MutT homolog 1 inhibitor by functionalized graphene oxide nanoparticles for enhanced chemo-photodynamic therapy triggers cell death in osteosarcoma.
Ovarian Neoplasms
Tumor-associated autoantibodies as early detection markers for ovarian cancer? A prospective evaluation.
Parkinson Disease
A valine to methionine polymorphism at codon 83 in the 8-oxo-dGTPase gene MTH1 is not associated with sporadic Parkinson's disease.
Parkinson Disease
Increased 8-oxo-dGTPase in the mitochondria of substantia nigral neurons in Parkinson's disease.
Prostatic Neoplasms
Antitumour activity of TH1579, a novel MTH1 inhibitor, against castration-resistant prostate cancer.
Pulmonary Arterial Hypertension
In Defense of the Nucleus: NUDT1 and Oxidative DNA Damage in Pulmonary Arterial Hypertension.
Pulmonary Arterial Hypertension
Oxidized DNA Precursors Cleanup by NUDT1 Contributes to Vascular Remodeling in Pulmonary Arterial Hypertension.
Squamous Cell Carcinoma of Head and Neck
NUDT1: A potential independent predictor for the prognosis of patients with oral squamous cell carcinoma.
Stomach Neoplasms
The role of miR-485-5p/NUDT1 axis in gastric cancer.
Testicular Neoplasms
Cadmium(II), unlike nickel(II), inhibits 8-oxo-dGTPase activity and increases 8-oxo-dG level in DNA of the rat testis, a target organ for cadmium(II) carcinogenesis.
Tuberculosis
A duplex real-time PCR assay for detection of mutT4 and mutT2 mutations in Mycobacterium tuberculosis of Beijing genotype.
Tuberculosis
Biochemical Properties of MutT2 Proteins from Mycobacterium tuberculosis and M. smegmatis and Their Contrasting Antimutator Roles in Escherichia coli.
Tuberculosis
Development of multiplex assay for rapid characterization of Mycobacterium tuberculosis.
Tuberculosis
Identification of Nudix Hydrolase Family Members with an Antimutator Role in Mycobacterium tuberculosis and Mycobacterium smegmatis.
Tuberculosis
Making sense of a missense mutation: characterization of MutT2, a Nudix hydrolase from Mycobacterium tuberculosis, and the G58R mutant encoded in W-Beijing strains of M. tuberculosis.
Tuberculosis
Mutations in mutT genes of Mycobacterium tuberculosis isolates of Beijing genotype.
Urinary Bladder Neoplasms
Antitumor effects of MutT homolog 1 inhibitors in human bladder cancer cells.
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3.6.1.55 8-oxo-dGTP diphosphatase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
