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Information on EC 3.6.1.22 - NAD+ diphosphatase and Organism(s) Homo sapiens

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EC Tree
     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.22 NAD+ diphosphatase
IUBMB Comments
This enzyme, described from plants, animals, and bacteria, can act on both reduced and oxidized forms of its substrate, although enzymes from different organisms have different preferences. Also acts on other dinucleotides, including NADP(H), FAD(H2), and the thionicotinamide analogues of NAD+ and NADP+.
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This record set is specific for:
Homo sapiens
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Word Map
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The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
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NAD(H)
+
H2O
=
AMP
+
NMN(H)
+
=
+
NADH
+
H2O
=
AMP
+
NMNH
+
=
+
Synonyms
alkaline phosphodiesterase i, nadh pyrophosphatase, nad pyrophosphatase, atnudx19, nudx19, nad+ pyrophosphatase, nadph pyrophosphohydrolase, nudix hydrolase 19, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
NAD diphosphatase
-
-
-
-
NAD pyrophosphatase
-
-
-
-
NAD+ diphosphatase
-
-
-
-
NAD+ pyrophosphatase
-
-
-
-
NADH pyrophosphatase
-
-
-
-
NADP pyrophosphatase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphorous acid anhydride hydrolysis
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -
SYSTEMATIC NAME
IUBMB Comments
NAD+ phosphohydrolase
This enzyme, described from plants, animals, and bacteria, can act on both reduced and oxidized forms of its substrate, although enzymes from different organisms have different preferences. Also acts on other dinucleotides, including NADP(H), FAD(H2), and the thionicotinamide analogues of NAD+ and NADP+.
CAS REGISTRY NUMBER
COMMENTARY hide
37289-33-1
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
NAD+ + H2O
AMP + NMN
show the reaction diagram
-
the enzyme is involved in NAD+ homeostasis
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
NAD+ + H2O
AMP + NMN
show the reaction diagram
-
the enzyme is involved in NAD+ homeostasis
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
NUD12_HUMAN
462
0
52076
Swiss-Prot
other Location (Reliability: 3)
NUD13_HUMAN
352
0
39688
Swiss-Prot
Mitochondrion (Reliability: 3)
PDB
SCOP
CATH
UNIPROT
ORGANISM
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Magni, G.; Amici, A.; Emanuelli, M.; Orsomando, G.; Raffaelli, N.; Ruggieri, S.
Enzymology of NAD+ homeostasis in man
Cell. Mol. Life Sci.
61
19-34
2004
Homo sapiens
Manually annotated by BRENDA team