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Abortion, Spontaneous
Rapamycin prevents spontaneous abortion by triggering decidual stromal cell autophagy-mediated NK cell residence.
Adenocarcinoma
Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling.
Adenocarcinoma
ITGA2, LAMB3, and LAMC2 may be the potential therapeutic targets in pancreatic ductal adenocarcinoma: an integrated bioinformatics analysis.
Arthritis
The loss of integrin ?2?1 suppresses joint inflammation and cartilage destruction in mouse models of rheumatoid arthritis.
Asthma
Genome-Wide Posttranscriptional Dysregulation by MicroRNAs in Human Asthma as Revealed by Frac-seq.
Breast Neoplasms
Epigenetic silencing of ITGA2 by MiR-373 promotes cell migration in breast cancer.
Breast Neoplasms
Integrin alpha-2 and beta-3 gene polymorphisms and breast cancer risk.
Breast Neoplasms
ITGA2 promotes expression of ACLY and CCND1 in enhancing breast cancer stemness and metastasis.
Carcinogenesis
ITGA2, LAMB3, and LAMC2 may be the potential therapeutic targets in pancreatic ductal adenocarcinoma: an integrated bioinformatics analysis.
Carcinogenesis
Lnc-STYK1-2 regulates bladder cancer cell proliferation, migration, and invasion by targeting miR-146b-5p expression and AKT/STAT3/NF-kB signaling.
Carcinogenesis
microRNA-30a arbitrates intestinal-type early gastric carcinogenesis by directly targeting ITGA2.
Carcinogenesis
Overexpressed ITGA2 promotes malignant tumor aggression by up-regulating PD-L1 expression through the activation of the STAT3 signaling pathway.
Carcinoma
Analysis of laser-microdissected prostate cancer tissues reveals potential tumor markers.
Carcinoma
Identification and Characterization of Cadmium-Related Genes in Liver Carcinoma.
Carcinoma
Is Integrin Subunit Alpha 2 Expression a Prognostic Factor for Liver Carcinoma? A Validation Experiment Based on Bioinformatics Analysis.
Carcinoma
ITGA2 Overexpression Promotes Esophageal Squamous Cell Carcinoma Aggression via FAK/AKT Signaling Pathway.
Carcinoma, Hepatocellular
ADAR1 p110 Enhances Adhesion of Tumor Cells to Extracellular Matrix in Hepatocellular Carcinoma via Up-Regulating ITGA2 Expression.
Carcinoma, Hepatocellular
HOXD3 was negatively regulated by YY1 recruiting HDAC1 to suppress progression of hepatocellular carcinoma cells via ITGA2 pathway.
Carcinoma, Hepatocellular
miR-128 modulates hepatocellular carcinoma by inhibition of ITGA2 and ITGA5 expression [Retraction].
Carcinoma, Hepatocellular
miR-128 modulates hepatocellular carcinoma by inhibition of ITGA2 and ITGA5 expression.
Carcinoma, Non-Small-Cell Lung
Up-regulation of YPEL1 and YPEL5 and down-regulation of ITGA2 in erlotinib-treated EGFR-mutant non-small cell lung cancer: A bioinformatic analysis.
Colonic Neoplasms
EZH2 regulates cofilin activity and colon cancer cell migration by targeting ITGA2 gene.
Colonic Neoplasms
Haplotype CGC from XPD, hOGG1 and ITGA2 polymorphisms increases the risk of nasopharyngeal carcinoma in Malaysia.
Colonic Neoplasms
Laminin ?1 orchestrates VEGFA functions in the ecosystem of colorectal carcinoma.
Colonic Neoplasms
Loss of Forkhead Box O3 Facilitates Inflammatory Colon Cancer: Transcriptome Profiling of the Immune Landscape and Novel Targets.
Colonic Neoplasms
Overexpression of long non-coding RNA00355 enhances proliferation, chemotaxis, and metastasis in colon cancer via promoting GTF2B-mediated ITGA2.
Colorectal Neoplasms
Integrin alpha-2 and beta-3 gene polymorphisms and colorectal cancer risk.
Colorectal Neoplasms
microRNA-16-5p-containing exosomes derived from bone marrow-derived mesenchymal stem cells inhibit proliferation, migration, and invasion, while promoting apoptosis of colorectal cancer cells by downregulating ITGA2.
Coronary Artery Disease
Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population.
Diabetes Mellitus
EDN1 Lys198Asn is associated with diabetic retinopathy in type 2 diabetes.
Diabetes Mellitus, Type 2
EDN1 Lys198Asn is associated with diabetic retinopathy in type 2 diabetes.
Diabetes Mellitus, Type 2
No association between the ITGA2 807T allele and retinopathy in french patients with type 2 diabetes.
Diabetes Mellitus, Type 2
Predictive role of multilocus genetic polymorphisms in cardiovascular disease and inflammation-related genes on chronic kidney disease in Type 2 diabetes--an 8-year prospective cohort analysis of 1163 patients.
Diabetic Retinopathy
A systematic meta-analysis of genetic association studies for diabetic retinopathy.
Esophageal Squamous Cell Carcinoma
ITGA2 Overexpression Promotes Esophageal Squamous Cell Carcinoma Aggression via FAK/AKT Signaling Pathway.
Fibromatosis, Gingival
Decreased Alpha 2 integrin gene expression in non-familial gingival fibromatosis: a report of two cases.
Glioblastoma
ITGA2 as a potential nanotherapeutic target for glioblastoma.
Graft vs Host Disease
Cyclosporine and methotrexate-related pharmacogenomic predictors of acute graft-versus-host disease.
Hepatitis C, Chronic
[Mathematic Model for Prediction of Liver Fibrosis Progression Rate in Patients with Chronic Hepatitis C Based on Combination of Genomic Markers].
Hypertension
Assessment of the genetic component of hypertension.
imp cyclohydrolase deficiency
The loss of integrin ?2?1 suppresses joint inflammation and cartilage destruction in mouse models of rheumatoid arthritis.
Infections
Involvement of Host Cell Integrin ?2 in Cryptosporidium parvum Infection.
Infections
Protective Vaccination Reshapes Hepatic Response to Blood-Stage Malaria of Genes Preferentially Expressed by NK Cells.
Ischemic Stroke
Association of integrin alpha2 gene variants with ischemic stroke.
Ischemic Stroke
Genetic polymorphism of ITGA2 C807T can increase the risk of ischemic stroke.
Ischemic Stroke
Polymorphism in Integrin ITGA2 is Associated with Ischemic Stroke and Altered Serum Cholesterol in Chinese Individuals.
Ischemic Stroke
Targeting Platelet GPVI Plus rt-PA Administration but Not ?2?1-Mediated Collagen Binding Protects against Ischemic Brain Damage in Mice.
Ischemic Stroke
[Association of the integrin gene polymorphisms with ischemic stroke and plasma lipid levels.]
Leukemia
Methylation-independent ITGA2 overexpression is associated with poor prognosis in de novo acute myeloid leukemia.
Leukemia, Myeloid, Acute
Downregulation of TREM-like transcript (TLT)-1 and collagen receptor ?2 subunit, two novel RUNX1-targets, contributes to platelet dysfunction in familial platelet disorder with predisposition to acute myelogenous leukemia.
Leukemia, Myeloid, Acute
Methylation-independent ITGA2 overexpression is associated with poor prognosis in de novo acute myeloid leukemia.
Liver Cirrhosis
[Mathematic Model for Prediction of Liver Fibrosis Progression Rate in Patients with Chronic Hepatitis C Based on Combination of Genomic Markers].
Liver Neoplasms
Identification and Characterization of Cadmium-Related Genes in Liver Carcinoma.
Liver Neoplasms
Is Integrin Subunit Alpha 2 Expression a Prognostic Factor for Liver Carcinoma? A Validation Experiment Based on Bioinformatics Analysis.
Lung Neoplasms
Up-regulation of YPEL1 and YPEL5 and down-regulation of ITGA2 in erlotinib-treated EGFR-mutant non-small cell lung cancer: A bioinformatic analysis.
Lymphatic Metastasis
ITGA2 Overexpression Promotes Esophageal Squamous Cell Carcinoma Aggression via FAK/AKT Signaling Pathway.
Malaria
Protective Vaccination Reshapes Hepatic Response to Blood-Stage Malaria of Genes Preferentially Expressed by NK Cells.
Melanoma
Integrin genes and susceptibility to human melanoma.
Metabolism, Inborn Errors
Genetic and metabolomic analysis of AdeD and AdeI mutants of de novo purine biosynthesis: cellular models of de novo purine biosynthesis deficiency disorders.
Microphthalmos
Rapamycin prevents spontaneous abortion by triggering decidual stromal cell autophagy-mediated NK cell residence.
Myocardial Infarction
Genetic polymorphisms, Biochemical Factors, and Conventional Risk Factors in Young and Elderly North Indian Patients With Acute Myocardial Infarction.
Myocardial Infarction
Myocardial infarction before and after the age of 45: Possible role of platelet receptor polymorphisms.
Myocardial Infarction
Prothrombotic gene polymorphisms and plasma factors in young north Indian survivors of acute myocardial infarction.
Myocardial Infarction
ST-elevation myocardial infarction, pulmonary embolism, and cerebral ischemic stroke in a patient with critically low levels of natural anticoagulants.
Nasopharyngeal Carcinoma
Haplotype CGC from XPD, hOGG1 and ITGA2 polymorphisms increases the risk of nasopharyngeal carcinoma in Malaysia.
Neoplasm Metastasis
ADAR1 p110 Enhances Adhesion of Tumor Cells to Extracellular Matrix in Hepatocellular Carcinoma via Up-Regulating ITGA2 Expression.
Neoplasm Metastasis
Collagen-rich omentum is a premetastatic niche for integrin ?2-mediated peritoneal metastasis.
Neoplasm Metastasis
Epigenetic silencing of ITGA2 by MiR-373 promotes cell migration in breast cancer.
Neoplasm Metastasis
Genes related to suppression of malignant phenotype induced by Maitake D-Fraction in breast cancer cells.
Neoplasm Metastasis
Haplotype CGC from XPD, hOGG1 and ITGA2 polymorphisms increases the risk of nasopharyngeal carcinoma in Malaysia.
Neoplasm Metastasis
HMGA2-FOXL2 Axis Regulates Metastases and Epithelial-to-mesenchymal Transition of Chemo-resistant Gastric Cancer.
Neoplasm Metastasis
HOXD3 was negatively regulated by YY1 recruiting HDAC1 to suppress progression of hepatocellular carcinoma cells via ITGA2 pathway.
Neoplasm Metastasis
Identification of RECQ1-regulated transcriptome uncovers a role of RECQ1 in regulation of cancer cell migration and invasion.
Neoplasm Metastasis
Immuno-proteomic discovery of tumor tissue autoantigens identifies olfactomedin 4, CD11b, and integrin alpha-2 as markers of colorectal cancer with liver metastases.
Neoplasm Metastasis
ITGA2 Overexpression Promotes Esophageal Squamous Cell Carcinoma Aggression via FAK/AKT Signaling Pathway.
Neoplasm Metastasis
ITGA2 promotes expression of ACLY and CCND1 in enhancing breast cancer stemness and metastasis.
Neoplasm Metastasis
miR-128 modulates hepatocellular carcinoma by inhibition of ITGA2 and ITGA5 expression.
Neoplasm Metastasis
Overexpressed ITGA2 contributes to paclitaxel resistance by ovarian cancer cells through the activation of the AKT/FoxO1 pathway.
Neoplasm Metastasis
Overexpression of long non-coding RNA00355 enhances proliferation, chemotaxis, and metastasis in colon cancer via promoting GTF2B-mediated ITGA2.
Neoplasms
A transcriptome-based protein network that identifies new therapeutic targets in colorectal cancer.
Neoplasms
ADAR1 p110 Enhances Adhesion of Tumor Cells to Extracellular Matrix in Hepatocellular Carcinoma via Up-Regulating ITGA2 Expression.
Neoplasms
Bioinformatic Analysis Suggests That Three Hub Genes May Be a Vital Prognostic Biomarker in Pancreatic Ductal Adenocarcinoma.
Neoplasms
Blockade of ITGA2 Induces Apoptosis and Inhibits Cell Migration in Gastric Cancer.
Neoplasms
Collagen-rich omentum is a premetastatic niche for integrin ?2-mediated peritoneal metastasis.
Neoplasms
Differential Connectivity in Colorectal Cancer Gene Expression Network
Neoplasms
Epigenetic silencing of ITGA2 by MiR-373 promotes cell migration in breast cancer.
Neoplasms
Exosomes-Mediated Transfer of Itga2 Promotes Migration and Invasion of Prostate Cancer Cells by Inducing Epithelial-Mesenchymal Transition.
Neoplasms
Fifteen-year follow-up of relapsed indolent non-Hodgkin lymphoma patients vaccinated with tumor-loaded dendritic cells.
Neoplasms
Gene and microRNA Expression Are Predictive of Tumor Response in Rectal Adenocarcinoma Patients Treated with Preoperative Chemoradiotherapy.
Neoplasms
Gene expression profiles reveal key genes for early diagnosis and treatment of adamantinomatous craniopharyngioma.
Neoplasms
Haplotype CGC from XPD, hOGG1 and ITGA2 polymorphisms increases the risk of nasopharyngeal carcinoma in Malaysia.
Neoplasms
Identification of a prostate cancer susceptibility gene on chromosome 5p13q12 associated with risk of both familial and sporadic disease.
Neoplasms
Immuno-proteomic discovery of tumor tissue autoantigens identifies olfactomedin 4, CD11b, and integrin alpha-2 as markers of colorectal cancer with liver metastases.
Neoplasms
Integrin ?2?1 inhibits MST1 kinase phosphorylation and activates Yes-associated protein oncogenic signaling in hepatocellular carcinoma.
Neoplasms
Is Integrin Subunit Alpha 2 Expression a Prognostic Factor for Liver Carcinoma? A Validation Experiment Based on Bioinformatics Analysis.
Neoplasms
ITGA2 as a potential nanotherapeutic target for glioblastoma.
Neoplasms
ITGA2 Overexpression Promotes Esophageal Squamous Cell Carcinoma Aggression via FAK/AKT Signaling Pathway.
Neoplasms
ITGA2 promotes expression of ACLY and CCND1 in enhancing breast cancer stemness and metastasis.
Neoplasms
Lewis antigen?negative pancreatic cancer: An aggressive subgroup.
Neoplasms
Mitofusin-2 over-expresses and leads to dysregulation of cell cycle and cell invasion in lung adenocarcinoma.
Neoplasms
Overexpressed ITGA2 contributes to paclitaxel resistance by ovarian cancer cells through the activation of the AKT/FoxO1 pathway.
Neoplasms
Overexpressed ITGA2 promotes malignant tumor aggression by up-regulating PD-L1 expression through the activation of the STAT3 signaling pathway.
Neoplasms
STIL is upregulated in nasopharyngeal carcinoma tissues and promotes nasopharyngeal carcinoma proliferation, migration and invasion.
Neoplasms
The ELF3-regulated lncRNA UBE2CP3 is over-stabilized by RNA-RNA interactions and drives gastric cancer metastasis via miR-138-5p/ITGA2 axis.
Osteosarcoma
MicroRNA-128 inhibits EMT of human osteosarcoma cells by directly targeting integrin ?2.
Ovarian Neoplasms
Overexpressed ITGA2 contributes to paclitaxel resistance by ovarian cancer cells through the activation of the AKT/FoxO1 pathway.
Pancreatic Neoplasms
Bioinformatics Analysis of a Prognostic miRNA Signature and Potential Key Genes in Pancreatic Cancer.
Pancreatic Neoplasms
Coexpression of UCA1 and ITGA2 in pancreatic cancer cells target the expression of miR-107 through focal adhesion pathway.
Pancreatic Neoplasms
Identification of hub genes with diagnostic values in pancreatic cancer by bioinformatics analyses and supervised learning methods.
Pancreatic Neoplasms
ITGA2, LAMB3, and LAMC2 may be the potential therapeutic targets in pancreatic ductal adenocarcinoma: an integrated bioinformatics analysis.
Pancreatic Neoplasms
miR-216a-mediated upregulation of TSPAN1 contributes to pancreatic cancer progression via transcriptional regulation of ITGA2.
Pancreatic Neoplasms
Overexpressed ITGA2 promotes malignant tumor aggression by up-regulating PD-L1 expression through the activation of the STAT3 signaling pathway.
Parasitic Diseases
Involvement of Host Cell Integrin ?2 in Cryptosporidium parvum Infection.
Prostatic Neoplasms
Exosomes-Mediated Transfer of Itga2 Promotes Migration and Invasion of Prostate Cancer Cells by Inducing Epithelial-Mesenchymal Transition.
Prostatic Neoplasms
Network-based analysis of prostate cancer cell lines reveals novel marker gene candidates associated with radioresistance and patient relapse.
Prostatic Neoplasms
Re: Regulation of the ITGA2 Gene by Epigenetic Mechanisms in Prostate Cancer.
Prostatic Neoplasms
Regulation of the ITGA2 gene by epigenetic mechanisms in prostate cancer.
Pulmonary Embolism
ST-elevation myocardial infarction, pulmonary embolism, and cerebral ischemic stroke in a patient with critically low levels of natural anticoagulants.
Stomach Neoplasms
Association between ITGA2 C807T polymorphism and gastric cancer risk.
Stomach Neoplasms
Blockade of ITGA2 Induces Apoptosis and Inhibits Cell Migration in Gastric Cancer.
Stroke
Association of BglII Polymorphism in ITGA2 and (894G/T and -786T/C) Polymorphisms in eNOS Gene With Stroke Susceptibility in Tunisian Patients ?2 Gene Polymorphism in ?2?1 Integrin and eNOS Gene Variants and Stroke.
Stroke
Association of integrin alpha2 gene variants with ischemic stroke.
Stroke
Integrin, alpha 2 gene C807T polymorphism and risk of ischemic stroke: a meta-analysis.
Stroke
ST-elevation myocardial infarction, pulmonary embolism, and cerebral ischemic stroke in a patient with critically low levels of natural anticoagulants.
Thrombophilia
Polymorphisms of F2 (G20210A), F5 (G1691A), F 7 (G10976A), F 13(G13T), FGB, ITGA2, ITGB3, PAI-I genes and its association with thrombotic complications in patients suffering from Takayasu aortoarteritis of Urals population.
Thrombophilia
ST-elevation myocardial infarction, pulmonary embolism, and cerebral ischemic stroke in a patient with critically low levels of natural anticoagulants.
Thyroid Cancer, Papillary
Ropivacaine inhibits proliferation, invasion, migration and promotes apoptosis of papillary thyroid cancer cells via regulating ITGA2 expression.
Thyroid Cancer, Papillary
The expression profile of integrin receptors and osteopontin in thyroid malignancies varies depending on the tumor progression rate and presence of BRAF V600E mutation.
Thyroid Neoplasms
Identification of Potential Biomarkers for Thyroid Cancer Using Bioinformatics Strategy: A Study Based on GEO Datasets.
Thyroid Neoplasms
The expression profile of integrin receptors and osteopontin in thyroid malignancies varies depending on the tumor progression rate and presence of BRAF V600E mutation.
Urinary Bladder Neoplasms
Lnc-STYK1-2 regulates bladder cancer cell proliferation, migration, and invasion by targeting miR-146b-5p expression and AKT/STAT3/NF-kB signaling.
Vascular Diseases
Platelet glycoprotein I(b)alpha and integrin alpha2 beta1 polymorphisms: gene frequencies and linkage disequilibrium in a population diversity panel.
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Szabados, E.; Hindmarsh, E.J.; Phillips, L.; Duggleby, R.G.; Christopherson, R.I.
5-Aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase from human CCRF-CEM leukemia cells: purification, pH dependence and inhibitors
Biochemistry
33
14237-14245
1994
Homo sapiens
brenda
Christopherson, R.I.; Williams, N.K.; Schoettle, S.L.; Szabados, E.; Hambley, T.W.; Manthey, M.K.
Inhibitors of dihydroorotase, amidophosphoribosyltransferase and IMP cyclohydrolase as potential drugs
Biochem. Soc. Trans.
23
888-893
1995
Homo sapiens
brenda
Rayl, E.A.; Moroson, B.A.; Beardsley, G.P.
The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping
J. Biol. Chem.
271
2225-2233
1996
Homo sapiens (P31939), Homo sapiens
brenda
Szabados, E.; Manthey, M.K.; Wilson, P.K.; Christopherson, R.I.
Inosine-5'-monophosphate analogues as inhibitors of human IMPcyclohydrolase and cellular growth
Biochem. Mol. Biol. Int.
44
617-623
1998
Homo sapiens
brenda
Vergis, J.M.; Bulock, K.G.; Fleming, K.G.; Beardsley, G.P.
Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity
J. Biol. Chem.
276
7727-7733
2001
Homo sapiens
brenda
Bulock, K.G.; Beardsley, G.P.; Anderson, K.S.
The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase): A surprising lack of substrate channeling
J. Biol. Chem.
277
22168-22174
2002
Homo sapiens
brenda
Wolan, D.W.; Cheong, C.G.; Greasley, S.E.; Wilson, I.A.
Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor
Biochemistry
43
1171-1183
2004
Homo sapiens (P31939), Homo sapiens
brenda
Cheong, C.G.; Wolan, D.W.; Greasley, S.E.; Horton, P.A.; Beardsley, G.P.; Wilson, I.A.
Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates
J. Biol. Chem.
279
18034-18045
2004
Homo sapiens (P31939), Homo sapiens
brenda
Vergis, J.M.; Beardsley, G.P.
Catalytic mechanism of the cyclohydrolase activity of human aminoimidazole carboxamide ribonucleotide formyltransferase/inosine monophosphate cyclohydrolase
Biochemistry
43
1184-1192
2004
Homo sapiens
brenda
Marie, S.; Heron, B.; Bitoun, P.; Timmerman, T.; Van Den Berghe, G.; Vincent, M.F.
AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC
Am. J. Hum. Genet.
74
1276-1281
2004
Homo sapiens (P31939), Homo sapiens
brenda
Penuelas, S.; Noe, V.; Ciudad, C.J.
Modulation of IMPDH2, survivin, topoisomerase I and vimentin increases sensitivity to methotrexate in HT29 human colon cancer cells
FEBS J.
272
696-710
2005
Homo sapiens (P31939), Homo sapiens
brenda
Boccalatte, F.E.; Voena, C.; Riganti, C.; Bosia, A.; DAmico, L.; Riera, L.; Cheng, M.; Ruggeri, B.; Jensen, O.N.; Goss, V.L.; Lee, K.; Nardone, J.; Rush, J.; Polakiewicz, R.D.; Comb, M.J.; Chiarle, R.; Inghirami, G.
The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL
Blood
113
2776-2790
2009
Homo sapiens (P31939)
brenda
Chen, X.; Zhao, J.; Xu, X.; Zeng, R.
Screening and cloning of IMP cyclohydrolase from a metagenomic cosmid library of a deep-sea sediment sample
Chin. J. Appl. Environ. Biol.
17
855-859
2011
Homo sapiens
-
brenda