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Information on EC 3.5.4.1 - cytosine deaminase and Organism(s) Pseudomonas aeruginosa

for references in articles please use BRENDA:EC3.5.4.1
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EC Tree
     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.4 In cyclic amidines
                3.5.4.1 cytosine deaminase
IUBMB Comments
Also acts on 5-methylcytosine.
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This record set is specific for:
Pseudomonas aeruginosa
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The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
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cytosine
+
H2O
=
uracil
+
NH3
+
=
+
Synonyms
apobec3g, apobec3, cytosine deaminase, apobec1, zn2+cdase, fca1p, isocytosine deaminase, coda protein, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Cytosine aminohydrolase
-
-
-
-
isocytosine deaminase
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -
SYSTEMATIC NAME
IUBMB Comments
cytosine aminohydrolase
Also acts on 5-methylcytosine.
CAS REGISTRY NUMBER
COMMENTARY hide
9025-05-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
cytosine + H2O
uracil + NH3
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
cytosine + H2O
uracil + NH3
show the reaction diagram
-
-
-
-
?
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A0A069QHX8_PSEAI
423
0
47075
TrEMBL
-
A0A367MEF5_PSEAI
256
0
28674
TrEMBL
-
A0A241XNX8_PSEAI
426
0
47390
TrEMBL
-
A0A2R3IUM6_PSEAI
423
0
47126
TrEMBL
-
A0A485FXG3_PSEAI
423
0
47177
TrEMBL
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sakai, T.; Yu, T.; Omata, S.
Distribution of enzymes related to cytidine degradation in bacteria
Agric. Biol. Chem.
40
1893-1895
1976
Achromobacter liquidum, Achromobacter polymorph, Klebsiella aerogenes, Enterobacter cloacae, Agrobacterium tumefaciens, Alcaligenes faecalis, Alcaligenes viscolactis, Niallia circulans, Bacillus subtilis, Citrobacter freundii, Escherichia coli, Lactiplantibacillus plantarum, Mycobacterium avium, Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas chlororaphis subsp. aureofaciens, Pseudomonas chlororaphis, Pseudomonas cruciviae, Pseudomonas fluorescens, Pseudomonas oleovorans, Pseudomonas schuylkilliensis, Ralstonia solanacearum, Pseudomonas coronafaciens pv. striafaciens, Pseudomonas taetrolens, Pseudomonas trifolii, Serratia marcescens, Serratia polymuthicum, Xanthomonas campestris, Xanthomonas arboricola pv. pruni, Xanthomonas campestris IAM 1671, Enterobacter cloacae IAM 1221, Xanthomonas arboricola pv. pruni IAM 1313, Alcaligenes faecalis IAM 0101, Escherichia coli K12 AKU 0005, Agrobacterium tumefaciens IAM 1526, Agrobacterium tumefaciens AKU 0300, Serratia polymuthicum AKU 0062, Alcaligenes viscolactis IAM 1517, Pseudomonas putida AKU 0820, Achromobacter polymorph AKU 0122
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Manually annotated by BRENDA team
Sakai, T.; Yu, T.; Taniguchi, K.; Omata, S.
Purification of cytosine deaminase from Pseudomonas aureofaciens
Agric. Biol. Chem.
39
2015-2020
1975
Klebsiella aerogenes, Enterobacter cloacae, Alcaligenes faecalis, Bacillus subtilis, Saccharomyces cerevisiae, Citrobacter freundii, Escherichia coli, Micrococcus flavus, Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas chlororaphis subsp. aureofaciens, Pseudomonas chlororaphis, Pseudomonas cruciviae, Pseudomonas fluorescens, Pseudomonas fragi, Pseudomonas schuylkilliensis, Ralstonia solanacearum, Pseudomonas coronafaciens pv. striafaciens, Pseudomonas taetrolens, Pseudomonas trifolii, Serratia marcescens, Serratia polymuthicum, Alcaligenes faecalis type S, Serratia marcescens type S, Enterobacter cloacae IAM 1221, Pseudomonas schuylkilliensis type S, Escherichia coli K12 AKU 0005, Pseudomonas chlororaphis type S, Proteus vulgaris type S, Pseudomonas aeruginosa type S, Pseudomonas putida type S, Proteus mirabilis type S, Pseudomonas trifolii type S, Enterobacter cloacae type S, Alcaligenes faecalis AKU 0101, Serratia polymuthicum AKU 0062, Pseudomonas cruciviae type S, Micrococcus flavus AKU 0502, Klebsiella aerogenes type S, Ralstonia solanacearum type S
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Manually annotated by BRENDA team