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Information on EC 3.5.1.98 - histone deacetylase and Organism(s) Bos taurus

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EC Tree
     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.98 histone deacetylase
IUBMB Comments
A class of enzymes that remove acetyl groups from N6-acetyl-lysine residues on a histone. The reaction of this enzyme is opposite to that of EC 2.3.1.48, histone acetyltransferase. Histone deacetylases (HDACs) can be organized into three classes, HDAC1, HDAC2 and HDAC3, depending on sequence similarity and domain organization. Histone acetylation plays an important role in regulation of gene expression. In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation . May be identical to EC 3.5.1.17, acyl-lysine deacylase.
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Word Map
The taxonomic range for the selected organisms is: Bos taurus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone
Synonyms
histone deacetylase, hdac1, hdac6, hdac2, hdac3, hdac4, hdac5, hdac8, hdac9, hdac7, more
SYSTEMATIC NAME
IUBMB Comments
histone amidohydrolase
A class of enzymes that remove acetyl groups from N6-acetyl-lysine residues on a histone. The reaction of this enzyme is opposite to that of EC 2.3.1.48, histone acetyltransferase. Histone deacetylases (HDACs) can be organized into three classes, HDAC1, HDAC2 and HDAC3, depending on sequence similarity and domain organization. Histone acetylation plays an important role in regulation of gene expression. In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation [4]. May be identical to EC 3.5.1.17, acyl-lysine deacylase.
CAS REGISTRY NUMBER
COMMENTARY hide
9076-57-7
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
HDAC8_BOVIN
377
0
41683
Swiss-Prot
other Location (Reliability: 1)
HDAC1_BOVIN
482
0
55106
Swiss-Prot
other Location (Reliability: 1)
A0A3Q1MDB6_BOVIN
898
0
97038
TrEMBL
other Location (Reliability: 2)
A0A3Q1N0A4_BOVIN
866
0
93657
TrEMBL
other Location (Reliability: 2)
A0A3Q1MKE1_BOVIN
1053
0
115753
TrEMBL
other Location (Reliability: 1)
F1MWS5_BOVIN
1069
0
117749
TrEMBL
other Location (Reliability: 2)
A0A3Q1NHU6_BOVIN
822
0
91147
TrEMBL
other Location (Reliability: 1)
A0A3Q1MR61_BOVIN
160
0
17786
TrEMBL
other Location (Reliability: 2)
F1N0W0_BOVIN
428
0
48848
TrEMBL
other Location (Reliability: 2)
A0A3Q1MXW3_BOVIN
1014
0
108646
TrEMBL
other Location (Reliability: 2)
A0A3Q1MIE7_BOVIN
453
0
51760
TrEMBL
Mitochondrion (Reliability: 4)
A0A3Q1NNS0_BOVIN
446
0
49737
TrEMBL
other Location (Reliability: 1)
F1MYR0_BOVIN
1089
0
119509
TrEMBL
other Location (Reliability: 2)
A0A3Q1MDJ2_BOVIN
456
0
50837
TrEMBL
other Location (Reliability: 1)
A0A3Q1MHD3_BOVIN
513
0
58372
TrEMBL
other Location (Reliability: 1)
A0A3Q1MD29_BOVIN
740
0
81352
TrEMBL
other Location (Reliability: 1)
A0A3Q1MPP6_BOVIN
990
0
107079
TrEMBL
other Location (Reliability: 5)
Q2T9N9_BOVIN
788
0
86743
TrEMBL
other Location (Reliability: 1)
Q0VC01_BOVIN
488
0
55334
TrEMBL
other Location (Reliability: 1)
A0A3Q1LWE9_BOVIN
1062
0
116585
TrEMBL
other Location (Reliability: 4)
G3MYR9_BOVIN
383
0
42315
TrEMBL
other Location (Reliability: 1)
F1N616_BOVIN
988
0
106852
TrEMBL
other Location (Reliability: 1)
F1MNA5_BOVIN
1117
0
121552
TrEMBL
other Location (Reliability: 2)
A0A3Q1NGD6_BOVIN
993
0
106487
TrEMBL
other Location (Reliability: 1)
F1MFZ7_BOVIN
478
0
54335
TrEMBL
other Location (Reliability: 1)
A0A3Q1MDL2_BOVIN
986
0
106555
TrEMBL
other Location (Reliability: 2)