Reference on EC 3.5.1.38 - glutamin-(asparagin-)ase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lebedeva, Z.I.; Berezov, T.T.
Improved method of purification and properties of glutaminase-asparaginase from Pseudomonas aurantiaca 548
Bull. Exp. Biol. Med.
11
1156-1158
1997
Pseudomonas chlororaphis subsp. aurantiaca, Pseudomonas chlororaphis subsp. aurantiaca 548
-
Ortlund, E.; Lacount, M.W.; Lewinski, K.; Lebioda, L.
Reactions of Pseudomonas 7A glutaminase-asparaginase with diazo analogues of glutamine and asparagine result in unexpected covalent inhibitions and suggests an unusual catalytic triad Thr-Tyr-Glu
Biochemistry
39
1199-1204
2000
BRENDA: Pseudomonas sp. (P10182), Pseudomonas sp. 7A (P10182), Pseudomonas sp. 7A
Textmining: Electron
Huser, A.; Klppner, U.; Rhm, K.H.
Cloning, sequence analysis, and expression of ansB from Pseudomonas fluorescens, encoding periplasmic glutaminase/asparaginase
FEMS Microbiol. Lett.
178
327-335
1999
BRENDA: Pseudomonas fluorescens
Textmining: Escherichia coli
Jakob, C.G.; Lewinski, K.; LaCount, M.W.; Roberts, J.; Lebioda, L.
Ion binding induces closed conformation in Pseudomonas 7A glutaminase-asparaginase (PGA): Crystal structure of the PGA-SO42-NH4+ complex at 1.7 A resolution
Biochemistry
36
923-931
1997
BRENDA: Pseudomonas sp. (P10182), Pseudomonas sp. 7A (P10182), Pseudomonas sp. 7A
Textmining: Electron
Lubkowski, J.; Wlodawer, A.; Ammon, H.L.; Copeland, T.D.; Swain, A.L.
Structural characterization of Pseudomonas 7A glutaminase-asparaginase
Biochemistry
33
10257-10265
1994
Pseudomonas sp., Pseudomonas sp. 7A
Ramakrishnan, M.S.; Joseph, R.
Characterization of an extracellular asparaginase of Rhodosporidium toruloides CBS14 exhibiting unique physicochemical properties
Can. J. Microbiol.
42
316-325
1996
Rhodotorula toruloides
-
Steckel, J.
Kinetic properties and inhibition of Acinetobacter glutaminase-asparaginase
Biochem. Pharmacol.
32
971-977
1983
BRENDA: Acinetobacter glutaminasificans
Textmining: Acinetobacter, Homo sapiens, Metazoa
Wlodawer, A.; Roberts, J.; Holcenberg, J.S.
Characterization of crystals of L-glutaminase-asparaginase from Acinetobacter glutaminasificans and Pseudomonas 7A
J. Mol. Biol.
112
515-519
1977
Acinetobacter glutaminasificans
Davidson, L.; Brear, D.R.; Wingard, P.; Hawkins, J.; Kitto, G.B.
Purification and properties of an L-glutaminase-L-asparaginase from Pseudomonas acidovorans
J. Bacteriol.
129
1379-1386
1977
Delftia acidovorans
Davidson, L.; Burkom, M.; Ahn, S.; Chang, L.C.; Kitto, B.
L-Asparaginases from Citrobacter freundii
Biochim. Biophys. Acta
480
282-294
1977
BRENDA: Citrobacter freundii
Textmining: Mus sp.
Holcenberg, J.S.; Teller, D.C.
Physical properties of antitumor glutaminase-asparaginase from Pseudomonas 7A
J. Biol. Chem.
251
5375-5380
1976
Pseudomonas sp., Pseudomonas sp. 7A
Roberts, J.
Purification and properties of a highly potent antitumor glutaminase-asparaginase from Pseudomonas 7A
J. Biol. Chem.
251
2119-2123
1976
BRENDA: Pseudomonas sp., Pseudomonas sp. 7A
Textmining: Pseudomonas, Mus sp., Lactate dehydrogenase-elevating virus
Imada, A.; Igarski, S.
Extracellular asparaginase-glutaminase of Tilachlidium humicola
J. Takeda Res. Lab.
32
140-151
1973
Tilachlidium humicola
-
Holcenberg, J.S.; Teller, D.C.; Roberts, J.; Dolowy, W.C.
Physical properties of Acinetobacter glutaminase-asparaginase with antitumor activity
J. Biol. Chem.
247
7750-7758
1972
BRENDA: Acinetobacter glutaminasificans
Textmining: Acinetobacter
Roberts, J.; Holcenberg, J.S.; Dolowy, W.C.
Isolation, crystallization, and properties of Achromobacteraceae glutaminase-asparaginase with antitumor activity
J. Biol. Chem.
247
84-90
1972
Achromobacter sp.
Sonawane, A.M.; Roehm, K.H.
A functional gltB gene is essential for utilization of acidic amino acids and expression of periplasmic glutaminase/asparaginase (PGA) by Pseudomonas putida KT2440
Mol. Genet. Genomics
271
33-39
2004
BRENDA: Pseudomonas putida, Pseudomonas putida KT 2240
Textmining: Pseudomonas putida KT2440, transposons
Sonawane, A.M.; Singh, B.; Roehm, K.H.
The AauR-AauS two-component system regulates uptake and metabolism of acidic amino acids in Pseudomonas putida
Appl. Environ. Microbiol.
72
6569-6577
2006
Pseudomonas putida, Pseudomonas putida KT 2240
Elzainy, T.A.; Ali, T.H.
Detection of the antitumor glutaminase-asparaginase in the filamentous fungi
J. Appl. Sci.
6
1389-1395
2006
Aspergillus niger, Penicillium chrysogenum, Penicillium palitans, Aspergillus niger NRRL 3
-
Yano, S.; Kamemura, A.; Yoshimune, K.; Moriguchi, M.; Yamamoto, S.; Tachiki, T.; Wakayama, M.
Analysis of essential amino acid residues for catalytic activity of glutaminase from Micrococcus luteus K-3
J. Biosci. Bioeng.
102
362-364
2006
Micrococcus, Pseudomonas sp. 7A
Reda, F.
Kinetic properties of Streptomyces canarius L-glutaminase and its anticancer efficiency
Braz. J. Microbiol.
46
957-968
2015
Streptomyces canarius
Riccardi, R; Holcenberg, JS; Glaubiger, DL; Wood, JH; Poplack, DG
L-asparaginase pharmacokinetics and asparagine levels in cerebrospinal fluid of rhesus monkeys and humans.
Cancer Res
41
4554-8
1981
Acinetobacter, Erwinia
Rozen, L; Noubouossie, D; Dedeken, L; Huybrechts, S; L, PQ; Ferster, A; Demulder, A
Different profile of thrombin generation in children with acute lymphoblastic leukaemia treated with native or pegylated asparaginase: A cohort study.
Pediatr Blood Cancer
2016
Homo sapiens
Yunis, AA; Arimura, GK; Russin, DJ
Human pancreatic carcinoma (MIA PaCa-2) in continuous culture: sensitivity to asparaginase.
Int J Cancer
19
218-35
1977
Homo sapiens
Tanaka, S; Robinson, EA; Appella, E; Miller, M; Ammon, HL; Roberts, J; Weber, IT; Wlodawer, A
Structures of amidohydrolases. Amino acid sequence of a glutaminase-asparaginase from Acinetobacter glutaminasificans and preliminary crystallographic data for an asparaginase from Erwinia chrysanthemi.
J Biol Chem
263
8583-91
1988
Acinetobacter, Acinetobacter glutaminasificans, Erwinia, Dickeya chrysanthemi
Ankel, EG; Zirneski, J; Ring, BJ; Holcenberg, JS
Effect of asparaginase on cell membranes of sensitive and resistant mouse lymphoma cells.
In Vitro
20
376-84
1984
Acinetobacter
Steinherz, PG
Transient, severe hyperlipidemia in patients with acute lymphoblastic leukemia treated with prednisone and asparaginase.
Cancer
74
3234-9
1994
Homo sapiens
Thu Huynh, V; Bergeron, S
Asparaginase Toxicities: Identification and Management in Patients With Acute Lymphoblastic Leukemia?.
Clin J Oncol Nurs
21
E248-E259
2017
Homo sapiens
Tiwari, K; Dubey, VK
Leishmania donovani asparaginase variants exhibit cytosolic localization.
Int J Biol Macromol
114
35-39
2018
Leishmania donovani
Schmer, G; Holcenberg, JS; Roberts, J
Kinetics of uptake and activity in mouse liver of glutaminase coupled to desialated orosomucoid.
Biochim Biophys Acta
538
397-405
1978
Mus sp., Pseudomonas sp. 7A
Sonneveld, P; Holcenberg, JS; van Bekkum, DW
Effect of succinylated Acinetobacter glutaminase-asparaginase treatment on an acute myeloid leukemia in the rat (BNML).
Eur J Cancer
15
1061-3
1979
Acinetobacter, Rattus
Holcenberg, JS; Borella, LD; Camitta, BM; Ring, BJ
Human pharmacology and toxicology of succinylated Acinetobacter glutaminase-asparaginase.
Cancer Res
39
3145-51
1979
Acinetobacter, Homo sapiens
Holcenberg, JS; Tang, E; Dolowy, WC
Effect of Acinetobacter glutaminase-asparaginase treatment on free amino acids in mouse tissues.
Cancer Res
35
1320-5
1975
Acinetobacter, Mus musculus, Escherichia coli
Holcenberg, JS; Schmer, G; Teller, DC
Biologic and physical properties of succinylated and glycosylated Acinetobacter glutaminase-asparaginase.
J Biol Chem
250
4165-70
1975
Acinetobacter, Homo sapiens
Roberts, J; McGregor, WG
Inhibition of mouse retroviral disease by bioactive glutaminase-asparaginase.
J Gen Virol
72 ( Pt 2)
299-305
1991
Mus musculus, Mus sp., Pseudomonas sp. 7A, Metazoa
Ammon, HL; Weber, IT; Wlodawer, A; Harrison, RW; Gilliland, GL; Murphy, KC; Sjölin, L; Roberts, J
Preliminary crystal structure of Acinetobacter glutaminasificans glutaminase-asparaginase.
J Biol Chem
263
150-6
1988
Acinetobacter glutaminasificans, Escherichia coli, Wolinella succinogenes, Pseudomonas sp. 7A, Electron
Pekhov, AA; Zanin, VA; Kozlov, AM; Iurchenko, AIa; Kondrat'eva, NA
[Biological properties of glutamin-(asparagin-)ase from Pseudomonas boreopolis 526]
Biull Eksp Biol Med
102
71-4
1986
[Pseudomonas] boreopolis, Escherichia coli, Mus musculus
Kien, CL; Anderson, AJ; Holcenberg, JS
Tissue nitrogen-sparing effect of high protein diet in mice with or without ascites tumor treated with Acinetobacter glutaminase-asparaginase.
Cancer Res
45
4876-82
1985
Acinetobacter, Mus sp.
Riley, V; Spackman, D; Fitzmaurice, MA; Roberts, J; Holcenberg, JS; Dolowy, WC
Therapeutic properties of a new glutaminase-asparaginase preparation and the influence of the lactate dehydrogenase-elevating virus.
Cancer Res
34
429-38
1974
Lactate dehydrogenase-elevating virus
Kien, CL; Holcenberg, JS
Amino acid utilization and urine protein excretion in children treated with succinylated Acinetobacter glutaminase-asparaginase.
Cancer Res
41
2056-62
1981
Acinetobacter, Homo sapiens
Warrell, RP; Arlin, ZA; Gee, TS; Chou, TC; Roberts, J; Young, CW
Clinical evaluation of succinylated Acinetobacter glutaminase-asparaginase in adult leukemia.
Cancer Treat Rep
66
1479-85
1982
Acinetobacter, Homo sapiens
Wu, MC; Arimura, GK; Holcenberg, JS; Yunis, AA
Sensitivity of cultured pancreatic carcinoma cells to Acinetobacter glutaminase-asparaginase.
In Vitro
18
750-4
1982
Acinetobacter
Kien, CL; Holcenberg, JS
Nitrogen utilization in mice bearing Ehrlich ascites tumor treated with Acinetobacter glutaminase-asparaginase.
Cancer Res
41
2051-5
1981
Acinetobacter, Metazoa, Mus sp.
Abuchowski, A; Davis, FF; Davis, S
Immunosuppressive properties and circulating life of Achromobacter glutaminase-asparaginase covalently attached to polyethylene glycol in man.
Cancer Treat Rep
65
1077-81
0
Achromobacter, Homo sapiens
Warrell, RP; Chou, TC; Gordon, C; Tan, C; Roberts, J; Sternberg, SS; Philips, FS; Young, CW
Phase I evaluation of succinylated Acinetobacter glutaminase-asparaginase in adults.
Cancer Res
40
4546-51
1980
Acinetobacter, Escherichia coli
Lubkowski, J; Wlodawer, A; Housset, D; Weber, IT; Ammon, HL; Murphy, KC; Swain, AL
Refined crystal structure of Acinetobacter glutaminasificans glutaminase-asparaginase.
Acta Crystallogr D Biol Crystallogr
50
826-32
1994
Acinetobacter glutaminasificans
Singh, B; Röhm, KH
Characterization of a Pseudomonas putida ABC transporter (AatJMQP) required for acidic amino acid uptake: biochemical properties and regulation by the Aau two-component system.
Microbiology
154
797-809
2008
Bacteria
Holcenberg, JS; Ericsson, L; Roberts, J
Amino acid sequence of the diazooxonorleucine binding site of Acinetobacter and Pseudomonas 7A glutaminase--asparaginase enzymes.
Biochemistry
17
411-7
1978
Acinetobacter, Pseudomonas, Escherichia coli
Chigaleĭchik, AG; Vinogradov, BD; Orlova, VS; Rylkin, SS
[L-glutaminase-asparaginase biosynthesis by a Pseudomonas boreopolis culture dependent on cultivation conditions]
Mikrobiologiia
47
409-13
0
[Pseudomonas] boreopolis
Spiers, AS; Wade, HE
Bacterial glutaminase in treatment of acute leukaemia.
Br Med J
1
1317-9
1976
Achromobacter, Metazoa
Lebedeva, ZI; Kabanova, EA; Berezov, TT
[The nature of functional groups in the active center of antitumor glutamin-(asparagin-)ase]
Biull Eksp Biol Med
105
426-9
1988
Pseudomonas
Lebedeva, ZI; Kabanova, EA; Berezov, TT
[Inactivation of microbial glutamin-(asparagin-)ase by azaserine and 6-diazo-5-oxo-L-norleucine]
Biull Eksp Biol Med
100
696-8
1985
Pseudomonas
Rosenfeld, H; Roberts, J
Enhancement of antitumor activity of glutamine antagonists 6-diazo-5-oxo-L-norleucine and acivicin in cell culture by glutaminase-asparaginase.
Cancer Res
41
1324-8
1981
Acinetobacter, Mus musculus
Lebedeva, ZI; Berezov, TT
[Molecular and catalytic properties of bacterial glutamin-(asparagin-)ase]
Vestn Ross Akad Med Nauk
57-61
1995
Pseudomonas
Baruch, M; Belotserkovsky, I; Hertzog, BB; Ravins, M; Dov, E; McIver, KS; Le Breton, YS; Zhou, Y; Cheng, CY; Chen, CY; Hanski, E
An extracellular bacterial pathogen modulates host metabolism to regulate its own sensing and proliferation.
Cell
156
97-108
2014
Homo sapiens, Mus musculus
Holcenberg, JS
Enzyme therapy of cancer, future studies.
Cancer Treat Rep
65 Suppl 4
61-5
1981
Homo sapiens, Metazoa, animal
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