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5-diazo-4-oxo-L-norvaline + H2O
?
aspartic acid + H2O
?
-
very low activity only for asparaginase B
-
-
?
beta-cyanoalanine + H2O
alanine + NH3
beta-D-aspartyl hydroxylammonium sulfate + H2O
L-Asp + hydroxylammonium sulfate
beta-L-aspartyl hydroxylammonium sulfate + H2O
L-Asp + hydroxylammonium sulfate
D-asparagine + H2O
D-aspartate + NH3
D-glutamine + H2O
D-glutamate + NH3
gamma-L-glutamyl hydroxylammonium sulfate + H2O
L-glutamate + hydroxylammonium sulfate
L-asparagine + H2O
L-aspartate + NH3
L-aspartate + NH3
L-asparagine + H2O
-
-
-
-
r
L-glutamine + H2O
L-glutamate + NH3
N-acetyl-L-asparagine + H2O
N-acetyl-L-aspartate + NH3
N-carbamoyl-L-asparagine + H2O
N-carbamoyl-L-aspartate + NH3
-
-
-
?
N-glycyl-L-asparagine + H2O
N-glycyl-L-aspartate + NH3
-
60% higher activity than on L-asparagine
-
?
succinamic acid + H2O
succinate + NH3
-
slow hydrolysis rate
-
?
additional information
?
-
5-diazo-4-oxo-L-norvaline + H2O
?
-
-
-
-
?
5-diazo-4-oxo-L-norvaline + H2O
?
-
-
-
-
?
5-diazo-4-oxo-L-norvaline + H2O
?
-
-
-
-
?
beta-cyanoalanine + H2O
alanine + NH3
-
slow hydrolysis rate
-
?
beta-cyanoalanine + H2O
alanine + NH3
-
slow hydrolysis rate
-
?
beta-D-aspartyl hydroxylammonium sulfate + H2O
L-Asp + hydroxylammonium sulfate
-
only asparaginase A, low activity
-
?
beta-D-aspartyl hydroxylammonium sulfate + H2O
L-Asp + hydroxylammonium sulfate
-
-
-
?
beta-L-aspartyl hydroxylammonium sulfate + H2O
L-Asp + hydroxylammonium sulfate
-
higher activity for asparaginase B
-
?
beta-L-aspartyl hydroxylammonium sulfate + H2O
L-Asp + hydroxylammonium sulfate
-
-
-
?
beta-L-aspartyl hydroxylammonium sulfate + H2O
L-Asp + hydroxylammonium sulfate
-
-
-
?
beta-L-aspartyl hydroxylammonium sulfate + H2O
L-Asp + hydroxylammonium sulfate
-
-
-
?
D-asparagine + H2O
D-aspartate + NH3
-
one third of the L-isomer
-
?
D-asparagine + H2O
D-aspartate + NH3
-
-
-
-
?
D-asparagine + H2O
D-aspartate + NH3
-
low activity
-
?
D-asparagine + H2O
D-aspartate + NH3
-
low activity
-
?
D-asparagine + H2O
D-aspartate + NH3
-
-
-
?
D-asparagine + H2O
D-aspartate + NH3
-
-
-
?
D-asparagine + H2O
D-aspartate + NH3
-
-
?
D-asparagine + H2O
D-aspartate + NH3
-
-
?
D-asparagine + H2O
D-aspartate + NH3
-
-
-
?
D-asparagine + H2O
D-aspartate + NH3
-
-
?
D-asparagine + H2O
D-aspartate + NH3
-
-
?
D-asparagine + H2O
D-aspartate + NH3
Tilachlidium humicola
-
-
-
?
D-glutamine + H2O
D-glutamate + NH3
-
one third of the L-isomer
-
?
D-glutamine + H2O
D-glutamate + NH3
-
low activity
-
?
D-glutamine + H2O
D-glutamate + NH3
-
low activity
-
?
D-glutamine + H2O
D-glutamate + NH3
-
-
-
?
D-glutamine + H2O
D-glutamate + NH3
-
-
?
D-glutamine + H2O
D-glutamate + NH3
-
-
?
D-glutamine + H2O
D-glutamate + NH3
-
-
-
?
D-glutamine + H2O
D-glutamate + NH3
-
-
?
D-glutamine + H2O
D-glutamate + NH3
-
-
?
D-glutamine + H2O
D-glutamate + NH3
Tilachlidium humicola
-
low activity
-
?
gamma-L-glutamyl hydroxylammonium sulfate + H2O
L-glutamate + hydroxylammonium sulfate
-
-
-
?
gamma-L-glutamyl hydroxylammonium sulfate + H2O
L-glutamate + hydroxylammonium sulfate
-
very low activities for both asparaginases A and B
-
?
gamma-L-glutamyl hydroxylammonium sulfate + H2O
L-glutamate + hydroxylammonium sulfate
-
-
-
?
gamma-L-glutamyl hydroxylammonium sulfate + H2O
L-glutamate + hydroxylammonium sulfate
-
same rate as for L-glutamine
-
?
gamma-L-glutamyl hydroxylammonium sulfate + H2O
L-glutamate + hydroxylammonium sulfate
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
involved in the maintenance of the correct L-asparagine/L-aspartate ratio
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
ratio of glutaminase to aspariginase activity is 0.7 to 1
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
involved in the maintenance of the correct L-asparagine/L-aspartate ratio
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
hydrolysed at a rate of 0.83 compared to L-glutamine
-
?
L-asparagine + H2O
L-aspartate + NH3
-
involved in the maintenance of the correct L-asparagine/L-aspartate ratio
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
ratio of glutaminase to aspariginase activity is 1.4 to 1
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
involved in the maintenance of the correct L-asparagine/L-aspartate ratio
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
ratio of glutaminase to aspariginase activity is 0.8 to 1
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
hydrolysed at a rate of 0.73 compared to L-glutamine
-
?
L-asparagine + H2O
L-aspartate + NH3
-
hydrolysis at a rate of 0.73 compared to L-glutamine
-
?
L-asparagine + H2O
L-aspartate + NH3
-
hydrolysed at a rate of 0.73 compared to L-glutamine
-
?
L-asparagine + H2O
L-aspartate + NH3
-
hydrolysis at a rate of 0.73 compared to L-glutamine
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
not active on D-asparagine
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
-
-
r
L-asparagine + H2O
L-aspartate + NH3
Tilachlidium humicola
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
higher activity for glutaminase than for asparaginase
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
involved in the maintenance of the correct L-glutamine/L-glutamate ratio
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
ratio of glutaminase to aspariginase activity is 0.7 to 1
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
involved in the maintenance of the correct L-glutamine/L-glutamate ratio
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
ratio of glutaminase to aspariginase activity is 0.7 to 1
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
low activity
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
involved in the maintenance of the correct L-glutamine/L-glutamate ratio
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
ratio of glutaminase to aspariginase activity is 1.4 to 1
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
involved in the maintenance of the correct L-glutamine/L-glutamate ratio
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
ratio of glutaminase to aspariginase activity is 0.8 to 1
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
higher activity for glutaminase than for asparaginase
-
?
L-glutamine + H2O
L-glutamate + NH3
-
higher activity for glutaminase than for asparaginase
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
higher activity for glutaminase than for asparaginase
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
higher activity for glutaminase than for asparaginase
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
one fifth of the activity on L-asparagine
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
Tilachlidium humicola
-
lower activity than for L-asparagine
-
?
N-acetyl-L-asparagine + H2O
N-acetyl-L-aspartate + NH3
-
5% of the activity compared to L-asparagine
-
?
N-acetyl-L-asparagine + H2O
N-acetyl-L-aspartate + NH3
-
-
-
?
additional information
?
-
-
acetamide, nicotinamide, and NAD are not hydrolyzed
-
-
?
additional information
?
-
-
acetamide, nicotinamide, and NAD are not hydrolyzed
-
-
?
additional information
?
-
-
acetamide, nicotinamide, and NAD are not hydrolyzed
-
-
?
additional information
?
-
-
acetamide, nicotinamide, and NAD are not hydrolyzed
-
-
?
additional information
?
-
-
glutaminase/asparaginase is downregulated during growth of the aauR mutant on Glu
-
-
?
additional information
?
-
-
glutaminase/asparaginase is downregulated during growth of the aauR mutant on Glu
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
L-asparagine + H2O
L-aspartate + NH3
L-glutamine + H2O
L-glutamate + NH3
additional information
?
-
L-asparagine + H2O
L-aspartate + NH3
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
involved in the maintenance of the correct L-asparagine/L-aspartate ratio
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
involved in the maintenance of the correct L-asparagine/L-aspartate ratio
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
hydrolysed at a rate of 0.83 compared to L-glutamine
-
?
L-asparagine + H2O
L-aspartate + NH3
-
involved in the maintenance of the correct L-asparagine/L-aspartate ratio
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
involved in the maintenance of the correct L-asparagine/L-aspartate ratio
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
hydrolysis at a rate of 0.73 compared to L-glutamine
-
?
L-asparagine + H2O
L-aspartate + NH3
-
hydrolysis at a rate of 0.73 compared to L-glutamine
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
?
L-asparagine + H2O
L-aspartate + NH3
-
-
-
?
L-asparagine + H2O
L-aspartate + NH3
Tilachlidium humicola
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
higher activity for glutaminase than for asparaginase
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
involved in the maintenance of the correct L-glutamine/L-glutamate ratio
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
involved in the maintenance of the correct L-glutamine/L-glutamate ratio
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
low activity
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
involved in the maintenance of the correct L-glutamine/L-glutamate ratio
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
involved in the maintenance of the correct L-glutamine/L-glutamate ratio
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
higher activity for glutaminase than for asparaginase
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
higher activity for glutaminase than for asparaginase
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
-
?
L-glutamine + H2O
L-glutamate + NH3
-
one fifth of the activity on L-asparagine
-
?
L-glutamine + H2O
L-glutamate + NH3
Tilachlidium humicola
-
lower activity than for L-asparagine
-
?
additional information
?
-
-
glutaminase/asparaginase is downregulated during growth of the aauR mutant on Glu
-
-
?
additional information
?
-
-
glutaminase/asparaginase is downregulated during growth of the aauR mutant on Glu
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(NH4)2SO4
-
inhibition above 10 mM
2-Hydroxy-5-nitrobenzyl bromide
-
40% inhibition at 10 mM, concentration-dependent, protection against inhibition in presence of substrate
5-diazo-4-oxo-D-norvaline
-
40% inhibition at 2 mM
5-Diazo-4-oxo-L-norvaline
6-diazo-5-oxo-L-norleucine
acivicin
-
competitive inhibition
aspartic acid
-
competitive inhibition, Ki: glutaminase activity 0.16 mM, asparaginase activity 0.53 mM
azaserine
-
competitive not reversible inhibition of both activities
Bromocresol green
-
52-66% inhibition at 1 mM
Cu2+
Tilachlidium humicola
-
slight inhibition at 1 mM
D-asparagine
Tilachlidium humicola
-
mixed type of competitive and non-competitive inhibition, Ki: 7.2-8.4 mM
EDTA
Tilachlidium humicola
-
slight inhibition at 8 mM
glutamic acid
-
competitive inhibition, Ki: glutaminase acitvity 5 mM, asparaginase activity 3 mM
iodoacetamide
-
slight inhibition
KCN
Tilachlidium humicola
-
slight inhibition at 8 mM
L-asparagine
-
competitive inhibition of glutaminase activity, Ki: 0.02 mM
L-methionine sulfoximine
-
competitive inhibition
N-bromosuccinimide
-
concentration-dependent inhibition, 40% at 10 mM, protection against inhibition in presence of substrate
NaAsO2
Tilachlidium humicola
-
90% inhibition at 8 mM
NaF
Tilachlidium humicola
-
slight inhibition at 8 mM
NH4Cl
-
weak non-competitive inhibition of glutaminase activity
Ni2+
Tilachlidium humicola
-
33% inhibition at 1 mM
Urea
-
95% loss of activity in 2.25 M
additional information
-
no product inhibition
-
5-Diazo-4-oxo-L-norvaline
-
50% inhibition at 0.6 mM
5-Diazo-4-oxo-L-norvaline
inactivation by covalent binding to Thr20 and Tyr34
5-Diazo-4-oxo-L-norvaline
-
marked inhibition at 0.1 mM
6-diazo-5-oxo-L-norleucine
-
irreversible inhibition at very low concentrations
6-diazo-5-oxo-L-norleucine
-
competitive not reversible inhibition of both activities after extensive dialysis
6-diazo-5-oxo-L-norleucine
inactivation by covalent binding to Thr20 and Tyr34
Hg2+
-
-
Hg2+
Tilachlidium humicola
-
slight inhibition at 1 mM
p-chloromercuribenzoate
-
complete inhibition at 0.1 mM, asparaginases A and B
p-chloromercuribenzoate
-
26% inhibition at 0.1 mM
p-chloromercuribenzoate
-
slight inhibition
p-chloromercuribenzoate
Tilachlidium humicola
-
slight inhibition
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Anaphylaxis
Induction of leukotriene production by bleomycin and asparaginase in mast cells in vitro and in patients in vivo.
Bacteremia
An extracellular bacterial pathogen modulates host metabolism to regulate its own sensing and proliferation.
Blast Crisis
Clinical evaluation of succinylated Acinetobacter glutaminase-asparaginase in adult leukemia.
Carcinoma
Human pancreatic carcinoma (MIA PaCa-2) in continuous culture: sensitivity to asparaginase.
Carcinoma
Sensitivity of cultured pancreatic carcinoma cells to Acinetobacter glutaminase-asparaginase.
Carcinoma, Ehrlich Tumor
Nitrogen utilization in mice bearing Ehrlich ascites tumor treated with Acinetobacter glutaminase-asparaginase.
Carcinoma, Ehrlich Tumor
Tissue nitrogen-sparing effect of high protein diet in mice with or without ascites tumor treated with Acinetobacter glutaminase-asparaginase.
Hyperlipidemias
Steroid and asparaginase-induced hyperlipidemia in leukemia.
Leishmaniasis, Visceral
Leishmania donovani asparaginase variants exhibit cytosolic localization.
Leukemia
Advances in Supportive Care for Acute Lymphoblastic Leukemia.
Leukemia
Clinical evaluation of succinylated Acinetobacter glutaminase-asparaginase in adult leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Clinical evaluation of succinylated Acinetobacter glutaminase-asparaginase in adult leukemia.
Leukemia, Myeloid, Acute
Effect of succinylated Acinetobacter glutaminase-asparaginase treatment on an acute myeloid leukemia in the rat (BNML).
Lymphoma
L-Asparagainases from Citrobacter freundii.
Neoplasms
Enhancement of antitumor activity of glutamine antagonists 6-diazo-5-oxo-L-norleucine and acivicin in cell culture by glutaminase-asparaginase.
Neoplasms
Human pancreatic carcinoma (MIA PaCa-2) in continuous culture: sensitivity to asparaginase.
Neoplasms
L-Asparagainases from Citrobacter freundii.
Neoplasms
Nitrogen utilization in mice bearing Ehrlich ascites tumor treated with Acinetobacter glutaminase-asparaginase.
Neoplasms
Phase I evaluation of succinylated Acinetobacter glutaminase-asparaginase in adults.
Neoplasms
Purification and properties of a highly potent antitumor glutaminase-asparaginase from Pseudomonas 7Z.
Neoplasms
Risk Factors for Asparaginase-associated Pancreatitis: A Systematic Review.
Neoplasms
The role of autophagy in asparaginase-induced immune suppression of macrophages.
Neoplasms
Tissue nitrogen-sparing effect of high protein diet in mice with or without ascites tumor treated with Acinetobacter glutaminase-asparaginase.
Pancreatitis
Risk Factors for Asparaginase-associated Pancreatitis: A Systematic Review.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Amino acid utilization and urine protein excretion in children treated with succinylated Acinetobacter glutaminase-asparaginase.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genetic markers for treatment-related pancreatitis in a cohort of Hispanic children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
In vivo imaging of antileukemic drug asparaginase reveals a rapid macrophage mediated clearance from the bone marrow.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Risk Factors for Asparaginase-associated Pancreatitis: A Systematic Review.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
The role of autophagy in asparaginase-induced immune suppression of macrophages.
Tetanus
Asparaginase display of polypeptides in the periplasm of Escherichia coli: potential rapid pepscan technique for antigen epitope mapping.
Thrombophilia
Changes in hypercoagulability by asparaginase: a randomized study between two asparaginases.
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Lebedeva, Z.I.; Berezov, T.T.
Improved method of purification and properties of glutaminase-asparaginase from Pseudomonas aurantiaca 548
Bull. Exp. Biol. Med.
11
1156-1158
1997
Pseudomonas chlororaphis subsp. aurantiaca, Pseudomonas chlororaphis subsp. aurantiaca 548
-
brenda
Ortlund, E.; Lacount, M.W.; Lewinski, K.; Lebioda, L.
Reactions of Pseudomonas 7A glutaminase-asparaginase with diazo analogues of glutamine and asparagine result in unexpected covalent inhibitions and suggests an unusual catalytic triad Thr-Tyr-Glu
Biochemistry
39
1199-1204
2000
Pseudomonas sp. (P10182), Pseudomonas sp. 7A (P10182), Pseudomonas sp. 7A
brenda
Huser, A.; Klppner, U.; Rhm, K.H.
Cloning, sequence analysis, and expression of ansB from Pseudomonas fluorescens, encoding periplasmic glutaminase/asparaginase
FEMS Microbiol. Lett.
178
327-335
1999
Pseudomonas fluorescens
brenda
Jakob, C.G.; Lewinski, K.; LaCount, M.W.; Roberts, J.; Lebioda, L.
Ion binding induces closed conformation in Pseudomonas 7A glutaminase-asparaginase (PGA): Crystal structure of the PGA-SO42-NH4+ complex at 1.7 A resolution
Biochemistry
36
923-931
1997
Pseudomonas sp. (P10182), Pseudomonas sp. 7A (P10182), Pseudomonas sp. 7A
brenda
Lubkowski, J.; Wlodawer, A.; Ammon, H.L.; Copeland, T.D.; Swain, A.L.
Structural characterization of Pseudomonas 7A glutaminase-asparaginase
Biochemistry
33
10257-10265
1994
Pseudomonas sp., Pseudomonas sp. 7A
brenda
Ramakrishnan, M.S.; Joseph, R.
Characterization of an extracellular asparaginase of Rhodosporidium toruloides CBS14 exhibiting unique physicochemical properties
Can. J. Microbiol.
42
316-325
1996
Rhodotorula toruloides
-
brenda
Steckel, J.
Kinetic properties and inhibition of Acinetobacter glutaminase-asparaginase
Biochem. Pharmacol.
32
971-977
1983
Acinetobacter glutaminasificans
brenda
Wlodawer, A.; Roberts, J.; Holcenberg, J.S.
Characterization of crystals of L-glutaminase-asparaginase from Acinetobacter glutaminasificans and Pseudomonas 7A
J. Mol. Biol.
112
515-519
1977
Acinetobacter glutaminasificans
brenda
Davidson, L.; Brear, D.R.; Wingard, P.; Hawkins, J.; Kitto, G.B.
Purification and properties of an L-glutaminase-L-asparaginase from Pseudomonas acidovorans
J. Bacteriol.
129
1379-1386
1977
Delftia acidovorans
brenda
Davidson, L.; Burkom, M.; Ahn, S.; Chang, L.C.; Kitto, B.
L-Asparaginases from Citrobacter freundii
Biochim. Biophys. Acta
480
282-294
1977
Citrobacter freundii
brenda
Holcenberg, J.S.; Teller, D.C.
Physical properties of antitumor glutaminase-asparaginase from Pseudomonas 7A
J. Biol. Chem.
251
5375-5380
1976
Pseudomonas sp., Pseudomonas sp. 7A
brenda
Roberts, J.
Purification and properties of a highly potent antitumor glutaminase-asparaginase from Pseudomonas 7A
J. Biol. Chem.
251
2119-2123
1976
Pseudomonas sp., Pseudomonas sp. 7A
brenda
Imada, A.; Igarski, S.
Extracellular asparaginase-glutaminase of Tilachlidium humicola
J. Takeda Res. Lab.
32
140-151
1973
Tilachlidium humicola
-
brenda
Holcenberg, J.S.; Teller, D.C.; Roberts, J.; Dolowy, W.C.
Physical properties of Acinetobacter glutaminase-asparaginase with antitumor activity
J. Biol. Chem.
247
7750-7758
1972
Acinetobacter glutaminasificans
brenda
Roberts, J.; Holcenberg, J.S.; Dolowy, W.C.
Isolation, crystallization, and properties of Achromobacteraceae glutaminase-asparaginase with antitumor activity
J. Biol. Chem.
247
84-90
1972
Achromobacter sp.
brenda
Sonawane, A.M.; Roehm, K.H.
A functional gltB gene is essential for utilization of acidic amino acids and expression of periplasmic glutaminase/asparaginase (PGA) by Pseudomonas putida KT2440
Mol. Genet. Genomics
271
33-39
2004
Pseudomonas putida, Pseudomonas putida KT 2240
brenda
Sonawane, A.M.; Singh, B.; Roehm, K.H.
The AauR-AauS two-component system regulates uptake and metabolism of acidic amino acids in Pseudomonas putida
Appl. Environ. Microbiol.
72
6569-6577
2006
Pseudomonas putida, Pseudomonas putida KT 2240
brenda
Elzainy, T.A.; Ali, T.H.
Detection of the antitumor glutaminase-asparaginase in the filamentous fungi
J. Appl. Sci.
6
1389-1395
2006
Aspergillus niger, Penicillium chrysogenum, Penicillium palitans, Aspergillus niger NRRL 3
-
brenda
Reda, F.
Kinetic properties of Streptomyces canarius L-glutaminase and its anticancer efficiency
Braz. J. Microbiol.
46
957-968
2015
Streptomyces canarius
brenda