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ADAM10 + H2O
?
-
shedding of the ectodomain of ADAM10
-
-
?
amyloid precursor protein + H2O
90-100 kDa non-amyloid N-terminal protein fragment
-
alpha-secretase activity
-
?
amyloid precursor protein + H2O
?
ephrin receptor B4 + H2O
?
-
-
-
?
EVHHQKLVFFAE + H2O
EVHH + QKLVFFAE
-
peptides derived from beta-amyloid precursor protein, comprises the predicted cleavage site
-
?
heparin-binding EGF-like growth factor + H2O
heparin-binding EGF-like growth factor fragment
-
cooperative action with bound protein kinase C, membrane-anchored substrate, ectodomain shedding
soluble product
?
insulin B chain + H2O
3 peptides
-
cleavage sites are Tyr16-Leu17 and Tyr26-Thr27
-
?
insulin B chain + H2O
?
-
-
-
-
?
Laminin + H2O
?
-
substrate of secreted form of enzyme
-
-
?
Mca-PLAQAV-Dpa-RSSSR-NH2 + H2O
Mca-PLAQA + V-Dpa-RSSSR-NH2
-
quenched fluorescent substrate
-
?
Mca-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Arg-NH2 + H2O
?
-
-
-
-
?
pro-heparin-binding EGF-like growth factor + H2O
?
SMAPGAVHLPQP + H2O
SMAPGAVH + LPQP
-
peptides derived from P75 TNF-receptor, comprises the predicted cleavage site
-
?
SPLAQAVRSSSR + H2O
SPLA + QAVRSSSR
-
peptides derived from TNF-alpha, comprises the predicted cleavage site
-
?
SPLAQAVRSSSR + H2O
SPLAQAVRS + SSR
-
peptides derived from TNF-alpha, comprises the predicted cleavage site
-
?
transmembrane collagen XVII + H2O
soluble collagen
-
-
-
?
transmembrane collagen XVII + H2O
soluble collagen ectodomain
-
substrate protein is an endothelial adhesion molecule on the surface of keratinocytes, protein is shed from the cell surface
cells show altered motility
?
additional information
?
-
amyloid precursor protein + H2O
?
-
enzyme shows alpha-secretase activity
-
?
amyloid precursor protein + H2O
?
enzyme shows alpha-secretase activity
-
?
amyloid precursor protein + H2O
?
-
enzyme shows alpha-secretase activity, the alpha-secretase might be composed of several ADAM enzymes in a complexe
-
?
amyloid precursor protein + H2O
?
-
-
-
-
?
beta-casein + H2O
?
-
recombinant metalloprotease domain is catalytically active against beta-casein
-
?
beta-casein + H2O
?
-
-
-
-
?
Fibronectin + H2O
?
-
recombinant metalloprotease domain is catalytically active against fibronectin
-
?
Fibronectin + H2O
?
-
-
-
-
?
Gelatin + H2O
?
-
recombinant metalloprotease domain is catalytically active gelatin
-
?
Gelatin + H2O
?
-
-
-
-
?
pro-heparin-binding EGF-like growth factor + H2O
?
-
-
-
-
?
pro-heparin-binding EGF-like growth factor + H2O
?
-
cooperative action with bound protein kinase C, membrane-anchored substrate, ectodomain shedding
-
?
proteins + H2O
peptides
-
-
-
?
proteins + H2O
peptides
-
-
-
?
proteins + H2O
peptides
-
-
-
?
proteins + H2O
peptides
-
-
-
?
proteins + H2O
peptides
-
-
-
?
proteins + H2O
peptides
-
-
-
?
proteins + H2O
peptides
-
-
?
proteins + H2O
peptides
-
-
?
proteins + H2O
peptides
enzymes of the ADAM family play importants roles in cell-cell fusion, intracellular signaling, and other cellular functions
-
?
proteins + H2O
peptides
-
-
-
?
proteins + H2O
peptides
-
-
-
?
proteins + H2O
peptides
-
-
-
?
proteins + H2O
peptides
-
-
-
?
proteins + H2O
peptides
-
-
?
additional information
?
-
-
interaction with endophilin I and SH3PX1, a SH3 domain- and phox homolog domain-containing protein, which may have a regulatory role by inhibiting the processing of the enzyme
-
?
additional information
?
-
-
the enzyme interacts in a RGD motif-independent manner with the alphaVbeta5-domain of integrins, e.g. on the surface of myeloma but not lymphoblastoid cells, dependent on cations Ca2+ or Mn2+
-
?
additional information
?
-
-
potential ADAM-9 sheddase substrates include growth factors and cytokines, which have been linked to atherosclerosis
-
-
?
additional information
?
-
-
ADAM-9 is capable of binding to alpha6beta1 and alphanubeta5 integrins
-
-
?
additional information
?
-
-
interaction with endophilin I and SH3PX1, a SH3 domain- and phox homolog domain-containing protein, which may have a regulatory role by inhibiting the processing of the enzyme
-
?
additional information
?
-
-
regulation of metalloprotease desintegrins via a cysteine-switch mechanism
-
?
additional information
?
-
-
enzyme can cleave and release epidermal growth factor and FGFR2iiib from cells
-
-
?
additional information
?
-
-
enzyme is a polyvalent ligand, through its disintegrin domain, for multiple renal integrins of the beta1 class
-
-
?
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Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (Q13443), Mus musculus (Q61072)
brenda
Asai, M.; Hattori, C.; Szabo, B.; Sasagawa, N.; Maruyama, K.; Tanuma, S.I.; Ishiura, S.
Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase
Biochem. Biophys. Res. Commun.
301
231-235
2003
Homo sapiens
brenda
Zhou, M.; Graham, R.; Russell, G.; Croucher, P.I.
MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin
Biochem. Biophys. Res. Commun.
280
574-580
2001
Homo sapiens
brenda
Hotoda, N.; Koike, H.; Sasagawa, N.; Ishiura, S.
A secreted form of human ADAM9 has an alpha-secretase activity for APP
Biochem. Biophys. Res. Commun.
293
800-805
2002
Homo sapiens (Q13443), Homo sapiens
brenda
Koike, H.; Tomioka, S.; Sorimachi, H.; Saido, T.C.; Maruyama, K.; Okuyama, A.; Fujisawa-Sehara, A.; Ohno, S.; Suzuki, K.; Ishiura, S.
Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein
Biochem. J.
343
371-375
1999
Mus musculus
brenda
Izumi, Y.; Hirata, M.; Hasuwa, H.; Iwamoto, R.; Umata, T.; Miyado, K.; Tamai, Y.; Kurisaki, T.; Sehara-Fujisawa, A.; Ohno, S.; Mekada, E.
A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor
EMBO J.
17
7260-7272
1998
Mus musculus
brenda
Amour, A.; Knight, C.G.; English, W.R.; Webster, A.; Slocombe, P.M.; Knauper, V.; Docherty, A.J.; Becherer, J.D.; Blobel, C.P.; Murphy, G.
The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs
FEBS Lett.
524
154-158
2002
Homo sapiens
brenda
Howard, L.; Nelson, K.K.; Maciewicz, R.A.; Blobel, C.P.
Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1
J. Biol. Chem.
274
31693-31699
1999
Homo sapiens, Mus musculus
brenda
Roghani, M.; Becherer, J.D.; Moss, M.L.; Atherton, R.E.; Erdjument-Bromage, H.; Arribas, J.; Blackburn, R.K.; Weskamp, G.; Tempst, P.; Blobel, C.P.
Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity
J. Biol. Chem.
274
3531-3540
1999
Mus musculus
brenda
McCulloch, D.R.; Harvey, M.; Herington, A.C.
The expression of the ADAMs proteases in prostate cancer cell lines and their regulation by dihydrotestosterone
Mol. Cell. Endocrinol.
167
11-21
2000
Homo sapiens
brenda
Schwettmann, L.; Tschesche, H.
Cloning and expression in Pichia pastoris of metalloprotease domain of ADAM 9 catalytically active against fibronectin
Protein Expr. Purif.
21
65-70
2001
Homo sapiens
brenda
Mahimkar, R.M.; Visaya, O.; Pollock, A.S.; Lovett, D.H.
The disintegrin domain of ADAM9: a ligand for multiple b1 renal integrins
Biochem. J.
385
461-468
2005
Mus musculus
brenda
Karadag, A.; Zhou, M.; Croucher, P.I.
ADAM-9 (MDC-9/meltrin-gamma), a member of the a disintegrin and metalloproteinase family, regulates myeloma-cell-induced interleukin-6 production in osteoblasts by direct interaction with the alpha(v)beta5 integrin
Blood
107
3271-3278
2006
Homo sapiens
brenda
Shintani, Y.; Higashiyama, S.; Ohta, M.; Hirabayashi, H.; Yamamoto, S.; Yoshimasu, T.; Matsuda, H.; Matsuura, N.
Overexpression of ADAM9 in non-small cell lung cancer correlates with brain metastasis
Cancer Res.
64
4190-4196
2004
Homo sapiens, Mus musculus
brenda
Mazzocca, A.; Coppari, R.; De Franco, R.; Cho, J.; Libermann, T.A.; Pinzani, M.; Toker, A.
A secreted form of ADAM9 promotes carcinoma invasion through tumor-stromal interactions
Cancer Res.
65
4728-4738
2005
Homo sapiens
brenda
Peduto, L.; Reuter, V.E.; Shaffer, D.R.; Scher, H.I.; Blobel, C.P.
Critical function for ADAM9 in mouse prostate cancer
Cancer Res.
65
9312-9319
2005
Mus musculus
brenda
Sung, S.; Kubo, H.; Shigemura, K.; Arnold, R.S.; Logani, S.; Wang, R.; Konaka, H.; Nakagawa, M.; Mousses, S.; Amin, M.; Anderson, C.; Johnstone, P.; Petros, J.A.; Marshall, F.F.; Zhau, H.E.; Chung, L.W.
Oxidative stress induces ADAM9 protein expression in human prostate cancer cells
Cancer Res.
66
9519-9526
2006
Homo sapiens
brenda
Asayesh, A.; Alanentalo, T.; Khoo, N.K.; Ahlgren, U.
Developmental expression of metalloproteases ADAM 9, 10, and 17 becomes restricted to divergent pancreatic compartments
Dev. Dyn.
232
1105-1114
2005
Mus musculus
brenda
Hirao, T.; Nanba, D.; Tanaka, M.; Ishiguro, H.; Kinugasa, Y.; Doki, Y.; Yano, M.; Matsuura, N.; Monden, M.; Higashiyama, S.
Overexpression of ADAM9 enhances growth factor-mediated recycling of E-cadherin in human colon cancer cell line HT29 cells
Exp. Cell Res.
312
331-339
2006
Mus musculus
brenda
Zigrino, P.; Mauch, C.; Fox, J.W.; Nischt, R.
Adam-9 expression and regulation in human skin melanoma and melanoma cell lines
Int. J. Cancer
116
853-859
2005
Homo sapiens
brenda
Carl-McGrath, S.; Lendeckel, U.; Ebert, M.; Roessner, A.; Roecken, C.
The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer
Int. J. Oncol.
26
17-24
2005
Homo sapiens
brenda
Yamada, D.; Ohuchida, K.; Mizumoto, K.; Ohhashi, S.; Yu, J.; Egami, T.; Fujita, H.; Nagai, E.; Tanaka, M.
Increased expression of ADAM 9 and ADAM 15 mRNA in pancreatic cancer
Anticancer Res.
27
793-799
2007
Homo sapiens
brenda
Deuss, M.; Reiss, K.; Hartmann, D.
Part-time alpha-secretases: the functional biology of ADAM 9, 10 and 17
Curr. Alzheimer Res.
5
187-201
2008
Mus musculus
brenda
Zigrino, P.; Steiger, J.; Fox, J.W.; Loeffek, S.; Schild, A.; Nischt, R.; Mauch, C.
Role of ADAM-9 disintegrin-cysteine-rich domains in human keratinocyte migration
J. Biol. Chem.
282
30785-30793
2007
Homo sapiens
brenda
Ma, G.F.; Liljestroem, M.; Ainola, M.; Chen, T.; Tiainen, V.M.; Lappalainen, R.; Konttinen, Y.T.; Salo, J.
Expression of ADAM9 (meltrin-gamma) around aseptically loosened total hip replacement implants
Rheumatology
45
808-814
2006
Homo sapiens
brenda
Parry, D.A.; Toomes, C.; Bida, L.; Danciger, M.; Towns, K.V.; McKibbin, M.; Jacobson, S.G.; Logan, C.V.; Ali, M.; Bond, J.; Chance, R.; Swendeman, S.; Daniele, L.L.; Springell, K.; Adams, M.; Johnson, C.A.; Booth, A.P.; Jafri, H.; Rashid, Y.; Banin, E.; Strom, T.M.; Farber, D.B.; Sharon, D.; Blobel, C.P.; Pugh, E.
Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in mice
Am. J. Hum. Genet.
84
683-691
2009
Homo sapiens, Mus musculus
brenda
Oksala, N.; Levula, M.; Airla, N.; Pelto-Huikko, M.; Ortiz, R.M.; Jaervinen, O.; Salenius, J.P.; Ozsait, B.; Komurcu-Bayrak, E.; Erginel-Unaltuna, N.; Huovila, A.P.; Kytoemaeki, L.; Soini, J.T.; Kaehoenen, M.; Karhunen, P.J.; Laaksonen, R.; Lehtimaeki, T.
ADAM-9, ADAM-15, and ADAM-17 are upregulated in macrophages in advanced human atherosclerotic plaques in aorta and carotid and femoral arteries--Tampere vascular study
Ann. Med.
41
279-290
2009
Homo sapiens
brenda
Zubel, A.; Flechtenmacher, C.; Edler, L.; Alonso, A.
Expression of ADAM9 in CIN3 lesions and squamous cell carcinomas of the cervix
Gynecol. Oncol.
114
332-336
2009
Homo sapiens
brenda
Kropatsch, R.; Petrasch-Parwez, E.; Seelow, D.; Schlichting, A.; Gerding, W.M.; Akkad, D.A.; Epplen, J.T.; Dekomien, G.
Generalized progressive retinal atrophy in the Irish Glen of Imaal Terrier is associated with a deletion in the ADAM9 gene
Mol. Cell. Probes
24
357-263
2010
Canis lupus familiaris (E7AIM5), Canis lupus familiaris
brenda
Cong, L.; Jia, J.
Promoter polymorphisms which regulate ADAM9 transcription are protective against sporadic Alzheimers disease
Neurobiol. Aging
32
54-62
2009
Homo sapiens
brenda
Mongaret, C.; Alexandre, J.; Thomas-Schoemann, A.; Bermudez, E.; Chereau, C.; Nicco, C.; Goldwasser, F.; Weill, B.; Batteux, F.; Lemare, F.
Tumor invasion induced by oxidative stress is dependent on membrane ADAM 9 protein and its secreted form
Int. J. Cancer
129
791-798
2011
Homo sapiens
brenda
Zigrino, P.; Nischt, R.; Mauch, C.
The disintegrin-like and cysteine-rich domains of ADAM-9 mediate interactions between melanoma cells and fibroblasts
J. Biol. Chem.
286
6801-6807
2011
Homo sapiens
brenda
Abety, A.N.; Fox, J.W.; Schoenefuss, A.; Zamek, J.; Landsberg, J.; Krieg, T.; Blobel, C.; Mauch, C.; Zigrino, P.
Stromal fibroblast-specific expression of ADAM-9 modulates proliferation and apoptosis in melanoma cells in vitro and in vivo
J. Invest. Dermatol.
132
2451-2458
2012
Mus musculus (Q61072), Mus musculus
brenda
Wang, X.; Polverino, F.; Rojas-Quintero, J.; Zhang, D.; Sánchez, J.; Yambayev, I.; Lindqvist, E.; Virtala, R.; Djukanovic, R.; Davies, D.; Wilson, S.; ODonnell, R.; Cunoosamy, D.; Hazon, P.; Higham, A.; Singh, D.; Olsson, H.; Owen, C.
A disintegrin and metalloproteinase domain-9 A novel proteinase culprit with multifarious contributions to chronic obstructive pulmonary disease
Am. J. Respir. Crit. Care Med.
198
1500-1518
2018
Mus musculus, Homo sapiens (Q13443)
-
brenda
English, W.; Siviter, R.; Hansen, M.; Murphy, G.
ADAM9 is present at endothelial cell - cell junctions and regulates monocyte - endothelial transmigration
Biochem. Biophys. Res. Commun.
493
1057-1062
2017
Mus musculus (Q61072)
brenda
Maretzky, T.; Swendeman, S.; Mogollon, E.; Weskamp, G.; Sahin, U.; Reiss, K.; Blobel, C.
Characterization of the catalytic properties of the membrane-anchored metalloproteinase ADAM9 in cell-based assays
Biochem. J.
474
1469-1479
2017
Mus musculus (Q61072)
brenda
Baggen, J.; Jan Thibaut, H.; Hurdiss, D.; Wahedi, M.; Van Vliet, A.; Van Kuppeveld, F.
Identification of the cell-surface protease adam9 as an entry factor for encephalomyocarditis virus
mBio
10
e1780
2019
Homo sapiens (Q13443), Homo sapiens
brenda
Wang, J.; Zhou, Y.; Fei, X.; Chen, X.; Yan, J.; Liu, B.; Zhu, Z.
ADAM9 functions as a promoter of gastric cancer growth which is negatively and post-transcriptionally regulated by miR-126
Oncol. Rep.
37
2033-2040
2017
Homo sapiens (Q13443)
brenda
Chiu, K.; Kuo, T.; Kuok, Q.; Lin, Y.; Hua, C.; Lin, C.; Su, P.; Lai, L.; Sher, Y.
ADAM9 enhances CDCP1 protein expression by suppressing MIR-218 for lung tumor metastasis
Sci. Rep.
5
16426
2015
Homo sapiens (Q13443), Homo sapiens
brenda