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malfunction
rheumatoid arthritis synovial fibroblasts display significantly higher caspase 3/7 activity upon camptothecin and FasL exposure when ADAM15 is down-regulated by specific small interfering RNAs. There is also a marked reduction of apoptosis upon knockdown of ADAM15 protein expression
physiological function
-
alternative mRNA splicing generates several ADAM15 isoforms containing different combinations of putative Src homology-3 (SH3) domain binding sites in their cytosolic tails. Alternative use of ADAM15 exons profoundly influences selection of SH3-containing cellular partner proteins, including the avid interactions with nephrocystin and sorting nexin-33
physiological function
-
overexpression of ADAM15 in melanoma cells reduces the migration, invasion and the anchorage dependent and independent cell growth of melanoma cells. The downregulation of ADAM15 plays an important role in melanoma progression. ADAM15 act as a tumorsuppressor in melanoma
physiological function
ADAM15 and acrogranin are present on and associated with the surface of guinea pig spermatozoa and play a role during sperm-egg binding
physiological function
ADAM15 is involved in major histocompatibility complex class I polypeptide-related sequence B shedding of PANC-1 cells
physiological function
ADAM15-rich exosomes have tumor suppressive functions. ADAM15-rich exosomes effectively inhibit vitronectin-induced cancer cell migration and activation of the MEK/extracellular regulated kinase signaling pathway
physiological function
apoptosis induction provokes direct ADAM15 binding to focal adhesion kinase and an associated enhanced phosphorylation of the FAK-Src complex
physiological function
exosomes rich in ADAM15 display enhanced binding affinity for integrin alpha/beta3 in an Arg-Gly-Asp-dependent manner and suppress vitronectin- and fibronectin-induced cell adhesion, growth, and migration, as well as in vivo tumor growth. Exosomal ADAM15 is released from human macrophages, and macrophage-derived ADAM15 exosomes have tumor inhibitory effects
physiological function
the enzyme contributes to apoptosis resistance in rheumatoid arthritis synovial fibroblasts by activating the Src/focal adhesion kinase pathway upon FasL exposure
physiological function
the recombinant human disintegrin domain of ADAM15 (1 pM) inhibits the growth and metastasis of Bel-7402 cell xenografts in zebrafish and a lower concentration (0.1 pM) induces severe apoptosis in the somatic cells of zebrafish
physiological function
ADAM15 mRNA is up to 4fold upregulated when endothelial cells are exposed to physiologic shear stress. This induction is associated with increased presence of ADAM15 protein in the cell lysates and on the surface. Induction of endothelial KLF2 by simvastatin treatment is associated with ADAM15 upregulation. KLF2 overexpression promotes ADAM15 expression under static conditions whereas KLF2 siRNA knockdown prevents ADAM15 induction by shear stress
physiological function
expression of ADAM15 natural isoforms in MDA-MB-231 cells leads to cell clustering to varying degree, without changes in epithelial mesenchymal transition markers vimentin, slug and E-cadherin. Expression leads to ADAM15 isoform specific, catalytic function dependent upregulation of claudin-1. The expression of ADAM15A, and to a lesser degree of C and E isoforms leads to an increase in claudin-1 expression in MDA-MB-231 cells, while ADAM15B has no effect. In MCF-7 cells, ADAM15E is the principal variant inducing claudin-1 expression. The PI3K/Akt/mTOR pathway is involved in regulating claudin-1 expression downstream of ADAM15. ADAM15 co-localizes with claudin-1 and ZO1 at cell-cell junctions
physiological function
shRNA-mediated knockdown of ADAM15 attenuates cell migration and invasion. ADAM15 upregulates MMP9 expression in lung cancer cells via activation of the MEK-ERK pathway. ADAM15 proteolytically cleaves and activates pro-MMP9 in vitro and interacts with MMP9 in vivo. Overexpression of ADAM15 in A-549 cells promotes cell invasion, while knocking down MMP9 attenuates cell invasive ability
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Kleino, I.; Ortiz, R.M.; Yritys, M.; Huovila, A.P.; Saksela, K.
Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins
J. Cell. Biochem.
108
877-885
2009
Homo sapiens
brenda
Ungerer, C.; Doberstein, K.; Buerger, C.; Hardt, K.; Boehncke, W.H.; Boehm, B.; Pfeilschifter, J.; Dummer, R.; Mihic-Probst, D.; Gutwein, P.
ADAM15 expression is downregulated in melanoma metastasis compared to primary melanoma
Biochem. Biophys. Res. Commun.
401
363-369
2010
Homo sapiens
brenda
Rybnikova, E.; Gluschenko, T.; Galeeva, A.; Tulkova, E.; Nalivaeva, N.N.; Makova, N.Z.; Turner, A.J.; Samoilov, M.
Differential expression of ADAM15 and ADAM17 metalloproteases in the rat brain after severe hypobaric hypoxia and hypoxic preconditioning
Neurosci. Res.
72
364-373
2012
Rattus norvegicus
brenda
Boehm, B.B.; Freund, I.; Krause, K.; Kinne, R.W.; Burkhardt, H.
ADAM15 adds to apoptosis resistance of synovial fibroblasts by modulating focal adhesion kinase signaling
Arthritis Rheumatol.
65
2826-2834
2013
Homo sapiens (Q13444)
brenda
Hou, Y.; Chu, M.; Du, F.F.; Lei, J.Y.; Chen, Y.; Zhu, R.Y.; Gong, X.H.; Ma, X.; Jin, J.
Recombinant disintegrin domain of ADAM15 inhibits the proliferation and migration of Bel-7402 cells
Biochem. Biophys. Res. Commun.
435
640-645
2013
Homo sapiens (Q13444), Homo sapiens
brenda
Lee, H.D.; Kim, Y.H.; Koo, B.H.; Kim, D.S.
The ADAM15 ectodomain is shed from secretory exosomes
BMB Rep.
48
277-282
2015
Homo sapiens (Q13444)
brenda
Hou, Y.; Chu, M.; Du, F.; Dai, H.; Chen, Y.; Jin, J.
Expression and activity of human serum albumin recombinant human disintegrin domain of ADAM15 fusion protein
Chin. J. Biol.
26
1551-1555
2013
Homo sapiens (Q13444)
-
brenda
Lee, H.D.; Koo, B.H.; Kim, Y.H.; Jeon, O.H.; Kim, D.S.
Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes
FASEB J.
26
3084-3095
2012
Homo sapiens (Q13444), Homo sapiens
brenda
Fried, D.; Boehm, B.B.; Krause, K.; Burkhardt, H.
ADAM15 protein amplifies focal adhesion kinase phosphorylation under genotoxic stress conditions
J. Biol. Chem.
287
21214-21223
2012
Homo sapiens (Q13444)
brenda
Duan, X.; Mao, X.; Sun, W.
ADAM15 is involved in MICB shedding and mediates the effects of gemcitabine on MICB shedding in PANC-1 pancreatic cancer cells
Mol. Med. Rep.
7
991-997
2013
Homo sapiens (Q13444)
brenda
Pasten, K.; Bastian, Y.; Roa-Espitia, A.L.; Maldonado-Garcia, D.; Mendoza-Hernandez, G.; Ortiz-Garcia, C.I.; Mujica, A.; Hernandez-Gonzalez, E.O.
ADAM15 participates in fertilization through a physical interaction with acrogranin
Reproduction
148
623-634
2014
Cavia porcellus (H0UVJ8), Cavia porcellus
brenda
Moss, M.L.; Miller, M.A.; Vujanovic, N.; Yoneyama, T.; Rasmussen, F.H.
Fluorescent substrates for ADAM15 useful for assaying and high throughput screening
Anal. Biochem.
514
42-47
2016
Homo sapiens (Q13444)
brenda
Babendreyer, A.; Molls, L.; Simons, I.M.; Dreymueller, D.; Biller, K.; Jahr, H.; Denecke, B.; Boon, R.A.; Bette, S.; Schnakenberg, U.; Ludwig, A.
The metalloproteinase ADAM15 is upregulated by shear stress and promotes survival of endothelial cells
J. Mol. Cell. Cardiol.
134
51-61
2019
Homo sapiens (Q13444)
brenda
Dong, D.D.; Zhou, H.; Li, G.
ADAM15 targets MMP9 activity to promote lung cancer cell invasion
Oncol. Rep.
34
2451-2460
2015
Homo sapiens (Q13444), Homo sapiens
brenda
Lorenzatti Hiles, G.; Bucheit, A.; Rubin, J.R.; Hayward, A.; Cates, A.L.; Day, K.C.; El-Sawy, L.; Kunju, L.P.; Daignault, S.; Lee, C.T.; Liebert, M.; Hussain, M.; Day, M.L.
ADAM15 Is functionally associated with the metastatic progression of human bladder cancer
PLoS ONE
11
e0150138
2016
Homo sapiens
brenda
Mattern, J.; Roghi, C.; Hurtz, M.; Knaeuper, V.; Edwards, D.; Poghosyan, Z.
ADAM15 mediates upregulation of claudin-1 expression in breast cancer cells
Sci. Rep.
9
12540
2019
Homo sapiens (Q13444)
brenda