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Alzheimer Disease
Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-? 42 Production.
Alzheimer Disease
Conformational dynamics of transmembrane domain 3 of presenilin 1 is associated with the trimming activity of ?-secretase.
Alzheimer Disease
Highly efficient production of the Alzheimer's ?-Secretase integral membrane protease complex by a multi-gene stable integration approach.
Alzheimer Disease
Membrane trafficking and proteolytic activity of ?-secretase in Alzheimer's disease.
Alzheimer Disease
Novel {gamma}-secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2, and PS1.
Alzheimer Disease
Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the ?-secretase.
Alzheimer Disease
Presenilin is the molecular target of acidic ?-secretase modulators in living cells.
Alzheimer Disease
Regulated intramembrane proteolysis: from the endoplasmic reticulum to the nucleus.
Alzheimer Disease
Requirement for small side chain residues within the GxGD-motif of presenilin for gamma-secretase substrate cleavage.
Alzheimer Disease
Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals.
Alzheimer Disease
Substrate specificity of gamma-secretase and other intramembrane proteases.
Arteriosclerosis
Not So Slim Anymore-Evidence for the Role of SUMO in the Regulation of Lipid Metabolism.
Atherosclerosis
Atheroprone flow activation of the sterol regulatory element binding protein 2 and nod-like receptor protein 3 inflammasome mediates focal atherosclerosis.
Atherosclerosis
MiR-33a is a therapeutic target in SPG4-related hereditary spastic paraplegia human neurons.
Atherosclerosis
n-3 Fatty acids ameliorate hepatic steatosis and dysfunction after LXR agonist ingestion in mice.
Atherosclerosis
Sterol regulatory element binding protein 2 activation of NLRP3 inflammasome in endothelium mediates hemodynamic-induced atherosclerosis susceptibility.
Brain Neoplasms
Autocrine platelet-derived growth factor-dependent gene expression in glioblastoma cells is mediated largely by activation of the transcription factor sterol regulatory element binding protein and is associated with altered genotype and patient survival in human brain tumors.
Carcinogenesis
Role of the Sterol Regulatory Element Binding Protein Pathway in Tumorigenesis.
Carcinoma, Hepatocellular
A mutant of HBx (HBxDelta127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase.
Carcinoma, Hepatocellular
Baicalin promoted site-2 protease and not site-1 protease in endoplasmic reticulum stress-induced apoptosis of human hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
I-CLIP: Improved Stratification of Advanced Hepatocellular Carcinoma Patients by Integrating Plasma IGF-1 into CLIP Score.
Cardiomyopathies
Phospholipid homeostasis and lipotoxic cardiomyopathy: A matter of balance.
Cholelithiasis
HNF1alpha and SREBP2 are important regulators of NPC1L1 in human liver.
Cholestasis
Not So Slim Anymore-Evidence for the Role of SUMO in the Regulation of Lipid Metabolism.
Choriocarcinoma
Luteolin Inhibits Proliferation and Induces Apoptosis of Human Placental Choriocarcinoma Cells by Blocking the PI3K/AKT Pathway and Regulating Sterol Regulatory Element Binding Protein Activity.
Cystadenoma
Estrogen-producing ovarian mucinous cystadenomas in postmenopausal women.
Cystadenoma, Mucinous
Estrogen-producing ovarian mucinous cystadenomas in postmenopausal women.
Cytomegalovirus Infections
Human Cytomegalovirus Infection Induces Adipocyte-Like Lipogenesis through Activation of Sterol Regulatory Element Binding Protein 1.
Diabetes Mellitus
[An association study of abdominal obesity and polymorphisms of UCP2 and SREBP1c genes]
Diabetes Mellitus, Type 2
[An association study of abdominal obesity and polymorphisms of UCP2 and SREBP1c genes]
Diabetic Nephropathies
Inhibition of SREBP with fatostatin does not attenuate early diabetic nephropathy in male mice.
Fatty Liver
Activation of sterol regulatory element binding protein and NLRP3 inflammasome in atherosclerotic lesion development in diabetic pigs.
Fatty Liver
Luteolin improves non-alcoholic fatty liver disease in db/db mice by inhibition of liver X receptor activation to down-regulate expression of sterol regulatory element binding protein 1c.
Fatty Liver
Protective effect of resveratrol derivatives on high-fat diet induced fatty liver by activating AMP-activated protein kinase.
Fatty Liver
Supplementation of Inulin with Various Degree of Polymerization Ameliorates Liver Injury and Gut Microbiota Dysbiosis in High Fat-Fed Obese Mice.
Fatty Liver
Validation of PAS Kinase, a Regulator of Hepatic Fatty Acid and Triglyceride Synthesis, as a Therapeutic Target for Nonalcoholic Steatohepatitis.
Glioblastoma
Autocrine platelet-derived growth factor-dependent gene expression in glioblastoma cells is mediated largely by activation of the transcription factor sterol regulatory element binding protein and is associated with altered genotype and patient survival in human brain tumors.
Hepatitis C
Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals.
Hepatitis C
Structural analysis of hepatitis C virus core-E1 signal peptide and requirements for cleavage of the genotype 3a signal sequence by signal peptide peptidase.
Hepatomegaly
Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement.
Herpes Simplex
The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator.
Hypercholesterolemia
Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1alpha.
Hypercholesterolemia
Effect of deficiency in SREBP cleavage-activating protein on lipid metabolism during intermittent hypoxia.
Hypercholesterolemia
Gender-related difference in altered gene expression of a sterol regulatory element binding protein, SREBP-2, by lead nitrate in rats: correlation with development of hypercholesterolemia.
Hypercholesterolemia
Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment.
Hypercholesterolemia
SREBP?2 expression pattern contributes to susceptibility of Mongolian gerbils to hypercholesterolemia.
Hyperlipidemias
Antiatherosclerotic effect of farnesoid X receptor.
Hyperlipoproteinemia Type II
Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment.
Hypertension
Roles of Dietary Bioactive Peptides in Redox Balance and Metabolic Disorders.
Hypertriglyceridemia
Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1alpha.
Hypertriglyceridemia
Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement.
Hypoglycemia
Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement.
Hypotension
Indinavir inhibits the expression of cytoplasmic aromatase and nuclear SREBP in the hippocampus of reperfusion injury-induced ischemic rats.
Infections
ChREBP, a glucose-responsive transcriptional factor, enhances glucose metabolism to support biosynthesis in human cytomegalovirus-infected cells.
Infections
Forkhead box transcription factor regulation and lipid accumulation by hepatitis C virus.
Infections
Hepatitis B virus X protein induces hepatic steatosis via transcriptional activation of SREBP1 and PPARgamma.
Infections
Hepatitis C and hepatic steatosis.
Infections
Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals.
Insulin Resistance
A rare missense mutation in a type 2 diabetes patient decreases the transcriptional activity of human sterol regulatory element binding protein-1.
Insulin Resistance
Activation of sterol regulatory element binding protein and NLRP3 inflammasome in atherosclerotic lesion development in diabetic pigs.
Insulin Resistance
The 1975 type Japanese diet improves the gut microbial flora and inhibits visceral fat accumulation in mice.
Insulin Resistance
The tacrolimus-induced glucose homeostasis imbalance in terms of the liver: From bench to bedside.
Leukemia
Multilocus genotypic association with vascular dementia by multifactor dimensionality reduction and entropy-based estimation.
Lipodystrophy
Subcellular localization of SREBP1 depends on its interaction with the C-terminal region of wild-type and disease related A-type lamins.
Liposarcoma
Nelfinavir inhibits regulated intramembrane proteolysis of sterol regulatory element binding protein-1 and activating transcription factor 6 in castration-resistant prostate cancer.
Liver Diseases
Luteolin improves non-alcoholic fatty liver disease in db/db mice by inhibition of liver X receptor activation to down-regulate expression of sterol regulatory element binding protein 1c.
Liver Diseases
Protective effect of resveratrol derivatives on high-fat diet induced fatty liver by activating AMP-activated protein kinase.
Liver Diseases
Validation of PAS Kinase, a Regulator of Hepatic Fatty Acid and Triglyceride Synthesis, as a Therapeutic Target for Nonalcoholic Steatohepatitis.
Metabolic Diseases
Berberine activates AMPK to suppress proteolytic processing, nuclear translocation and target DNA binding of SREBP-1c in 3T3-L1 adipocytes.
Nasopharyngeal Carcinoma
Long intergenic non-protein coding RNA 02570 promotes nasopharyngeal carcinoma progression by adsorbing microRNA miR-4649-3p thereby upregulating both sterol regulatory element binding protein 1, and fatty acid synthase.
Neoplasm Metastasis
SREBP-1 inhibitor Betulin enhances the antitumor effect of Sorafenib on hepatocellular carcinoma via restricting cellular glycolytic activity.
Neoplasms
A mixture of the aqueous extract of Garcinia cambogia, soy peptide and L: -carnitine reduces the accumulation of visceral fat mass in rats rendered obese by a high fat diet.
Neoplasms
Aberrant Activation of Fatty Acid Synthesis Suppresses Primary Cilium Formation and Distorts Tissue Development.
Neoplasms
Alisol A 24-Acetate Prevents Hepatic Steatosis and Metabolic Disorders in HepG2 Cells.
Neoplasms
Attenuation of Endoplasmic Reticulum Stress-Mediated Liver Damage by Mulberry Leaf Diet in Streptozotocin-Induced Diabetic Rats.
Neoplasms
Effects of dietary energy on antioxidant capacity, glucose-lipid metabolism and meat fatty acid profile of Holstein bulls at different ages.
Neoplasms
Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD).
Neoplasms
Estrogen-producing ovarian mucinous cystadenomas in postmenopausal women.
Neoplasms
Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth.
Neoplasms
High glucose microenvironment accelerates tumor growth via SREBP1-autophagy axis in pancreatic cancer.
Neoplasms
Highly efficient production of the Alzheimer's ?-Secretase integral membrane protease complex by a multi-gene stable integration approach.
Neoplasms
Human prostate cancer cells lack feedback regulation of low-density lipoprotein receptor and its regulator, SREBP2.
Neoplasms
Inhibition of ?-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1.
Neoplasms
Lipid Regulatory Proteins as Potential Therapeutic Targets for Ovarian Cancer in Obese Women.
Neoplasms
MicroRNAs and oncogenic transcriptional regulatory networks controlling metabolic reprogramming in cancers.
Neoplasms
Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation.
Neoplasms
Platyphylloside Isolated From Betula platyphylla Inhibit Adipocyte Differentiation and Induce Lipolysis Via Regulating Adipokines Including PPAR? in 3T3-L1 Cells.
Neoplasms
SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis.
Neoplasms
SREBP-1c as a molecular bridge between lipogenesis and cell cycle progression of clear cell renal carcinoma.
Neoplasms
Unliganded thyroid hormone receptor-beta1 represses liver X receptor alpha/oxysterol-dependent transactivation.
Nephrotic Syndrome
Hepatic tissue sterol regulatory element binding protein 2 and low-density lipoprotein receptor in nephrotic syndrome.
Neuroblastoma
Abeta((25-35)) Attenuated SREBP Level in Nuclear Extracts of Serum-Deprived Human Neuroblastoma Cells.
Neuroblastoma
Dysregulation of SREBP2 induces BACE1 expression.
Neuroblastoma
U18666A, an activator of sterol regulatory element binding protein pathway, modulates presynaptic dopaminergic phenotype of SH-SY5Y neuroblastoma cells.
Non-alcoholic Fatty Liver Disease
Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD).
Non-alcoholic Fatty Liver Disease
Evaluation of Fbxw7 expression and its correlation with expression of SREBP-1 in a mouse model of NAFLD.
Non-alcoholic Fatty Liver Disease
Luteolin improves non-alcoholic fatty liver disease in db/db mice by inhibition of liver X receptor activation to down-regulate expression of sterol regulatory element binding protein 1c.
Non-alcoholic Fatty Liver Disease
Not So Slim Anymore-Evidence for the Role of SUMO in the Regulation of Lipid Metabolism.
Non-alcoholic Fatty Liver Disease
Protective effect of resveratrol derivatives on high-fat diet induced fatty liver by activating AMP-activated protein kinase.
Non-alcoholic Fatty Liver Disease
Regulation of SREBP-2 intracellular trafficking improves impaired autophagic flux and alleviates endoplasmic reticulum stress in NAFLD.
Non-alcoholic Fatty Liver Disease
Validation of PAS Kinase, a Regulator of Hepatic Fatty Acid and Triglyceride Synthesis, as a Therapeutic Target for Nonalcoholic Steatohepatitis.
Obesity
Dietary cholesterol interacts with SREBF1 to modulate obesity in Chinese children.
Obesity
Endocannabinoid system in cancer cachexia.
Obesity
Genetic variations in sterol regulatory element binding protein cleavage-activating protein (SCAP) are associated with blood pressure in overweight/obese Chinese children.
Obesity
Polymorphisms in stearoyl coa desaturase and sterol regulatory element binding protein interact with N-3 polyunsaturated fatty acid intake to modify associations with anthropometric variables and metabolic phenotypes in Yup'ik people.
Obesity
Roles of Dietary Bioactive Peptides in Redox Balance and Metabolic Disorders.
Obesity
Sterol regulatory element binding protein 1c (SREBP-1c) expression in human obesity.
Obesity
[Association of rs2228314 polymorphism in SREBP2 with serum lipid levels and obesity among children and adolescents].
Obesity, Abdominal
[An association study of abdominal obesity and polymorphisms of UCP2 and SREBP1c genes]
Paralysis
Neutral Lipid Cacostasis Contributes to Disease Pathogenesis in Amyotrophic Lateral Sclerosis.
Prostatic Neoplasms
Nelfinavir and nelfinavir analogs block site-2 protease cleavage to inhibit castration-resistant prostate cancer.
protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency
SIRT6 controls hepatic lipogenesis by suppressing LXR, ChREBP, and SREBP1.
Starvation
Genetically Based Physiological Responses to Overwinter Starvation in Gibel Carp (Carassius gibelio).
Starvation
Iron - A Key Nexus in the Virulence of Aspergillus fumigatus.
Stroke
Elevated sterol regulatory elementary binding protein 1 and GluA2 levels in the hippocampal nuclear fraction of Genetic Absence Epilepsy Rats from Strasbourg.
Tics
Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6.
Tuberculosis
M. tuberculosis intramembrane protease Rip1 controls transcription through three anti-sigma factor substrates.
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Rawson, R.; Zelenski, N.; Nijhawan, D.; Ye, J.; Sakai, J.; Hasan, M.; Chang, T.; Brown, M.; Goldstein, J.
Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs
Mol. Cell
1
47-57
1997
Homo sapiens (O43462), Cricetulus griseus (O54862)
brenda
Zelenski, N.; Rawson, R.; Brown, M.; Goldstein, J.
Membrane topology of S2P, a protein required for intramembranous cleavage of sterol regulatory element-binding proteins
J. Biol. Chem.
274
21973-21980
1999
Homo sapiens (O43462)
brenda
Brown, M.; Ye, J.; Rawson, R.; Goldstein, J.
Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans
Cell
100
391-398
2000
Homo sapiens (O43462)
brenda
Ye, J.; Dav, U.; Grishin, N.; Goldstein, J.; Brown, M.
Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease
Proc. Natl. Acad. Sci. USA
97
5123-5128
2000
Homo sapiens (O43462)
brenda
Shen, J.; Prywes, R.
Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6
J. Biol. Chem.
279
43046-43051
2004
Homo sapiens
brenda
Colgan, S.M.; Tang, D.; Werstuck, G.H.; Austin, R.C.
Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2
Int. J. Biochem. Cell Biol.
39
1843-1851
2007
Homo sapiens
brenda
Kinch, L.N.; Ginalski, K.; Grishin, N.V.
Site-2 protease regulated intramembrane proteolysis: Sequence homologs suggest an ancient signaling cascade
Protein Sci.
15
84-93
2006
Synechocystis sp., Arabidopsis thaliana, Halalkalibacterium halodurans, Caenorhabditis elegans, Deinococcus radiodurans, Drosophila melanogaster, Escherichia coli, Giardia intestinalis, Halobacterium sp., Homo sapiens, Methanothermobacter thermautotrophicus, Mycobacterium leprae, Plasmodium falciparum, Pyrobaculum aerophilum, Thermoplasma volcanium, Thermotoga maritima, Treponema pallidum
brenda
Chen, G.; Zhang, X.
New insights into S2P signaling cascades: regulation, variation and conservation
Protein Sci.
19
2015-2030
2010
Bordetella bronchiseptica, Bacillus subtilis, Caulobacter vibrioides, Cryptococcus neoformans, Escherichia coli, Enterococcus faecalis, Homo sapiens, Methanocaldococcus jannaschii, Mycobacterium tuberculosis, Pseudomonas aeruginosa, Streptococcus uberis
brenda
Guan, M.; Fousek, K.; Chow, W.A.
Nelfinavir inhibits regulated intramembrane proteolysis of sterol regulatory element binding protein-1 and activating transcription factor 6 in castration-resistant prostate cancer
FEBS J.
279
2399-2411
2012
Homo sapiens
brenda
Yu, Z.; Luo, X.; Wang, C.; Ye, J.; Liu, S.; Xie, L.; Wang, F.; Bao, J.
Baicalin promoted site-2 protease and not site-1 protease in endoplasmic reticulum stress-induced apoptosis of human hepatocellular carcinoma cells
FEBS Open Bio
6
1093-1101
2016
Homo sapiens
brenda
Guan, M.; Su, L.; Yuan, Y.C.; Li, H.; Chow, W.A.
Nelfinavir and nelfinavir analogs block site-2 protease cleavage to inhibit castration-resistant prostate cancer
Sci. Rep.
5
9698
2015
Homo sapiens, Methanocaldococcus jannaschii (Q57837), Methanocaldococcus jannaschii
brenda