Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Reference on EC 3.4.24.81 - ADAM10 endopeptidase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vincent, B.; Paitel, E.; Saftig, P.; Frobert, Y.; Hartmann, D.; De Strooper, B.; Grassi, J.; Lopez-Perez, E.; Checler, F.
The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein
J. Biol. Chem.
276
37743-37746
2001
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Lopez-Perez, E.; Zhang, Y.; Frank, S.J.; Creemers, J.; Seidah, N.; Checler, F.
Constitutive a-secretase cleavage of the b-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10
J. Neurochem.
76
1532-1539
2001
Homo sapiens
Manually annotated by BRENDA team
Anders, A.; Gilbert, S.; Garten, W.; Postina, R.; Fahrenholz, F.
Regulation of the alpha-secretase ADAM10 by its prodomain and proprotein convertases
FASEB J.
15
1837-1839
2001
Bos taurus, Homo sapiens
Manually annotated by BRENDA team
Lemjabbar, H.; Basbaum, C.
Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells
Nat. Med.
8
41-46
2002
Homo sapiens
Manually annotated by BRENDA team
Gutwein, P.; Mechtersheimer, S.; Riedle, S.; Stoeck, A.; Gast, D.; Joumaa, S.; Zentgraf, H.; Fogel, M.; Altevogt, P.
ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles
FASEB J.
17
292-294
2003
Homo sapiens
Manually annotated by BRENDA team
Asai, M.; Hattori, C.; Szabo, B.; Sasagawa, N.; Maruyama, K.; Tanuma, S.I.; Ishiura, S.
Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase
Biochem. Biophys. Res. Commun.
301
231-235
2003
Homo sapiens
Manually annotated by BRENDA team
Gatta, L.B.; Albertini, A.; Ravid, R.; Finazzi, D.
Levels of beta-secretase BACE and alpha-secretase ADAM10 mRNAs in Alzheimer hippocampus
NeuroReport
13
2031-2033
2002
Homo sapiens
Manually annotated by BRENDA team
Colciaghi, F.; Borroni, B.; Pastorino, L.; Marcello, E.; Zimmermann, M.; Cattabeni, F.; Padovani, A.; Di Luca, M.
alpha-secretase ADAM10 as well as aAPPs is reduced in platelets and CSF of Alzheimer Disease patients
Mol. Med.
8
67-74
2002
Homo sapiens
Manually annotated by BRENDA team
Yan, Y.; Shirakabe, K.; Werb, Z.
The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors
J. Cell Biol.
158
221-226
2002
Chlorocebus aethiops, Homo sapiens
Manually annotated by BRENDA team
Murai, T.; Miyauchi, T.; Yanagida, T.; Sako, Y.
Epidermal growth factor-regulated activation of Rac GTPase enhances CD44 cleavage by metalloproteinase disintegrin ADAM10
Biochem. J.
395
65-71
2006
Homo sapiens
Manually annotated by BRENDA team
Janes, P.W.; Saha, N.; Barton, W.A.; Kolev, M.V.; Wimmer-Kleikamp, S.H.; Nievergall, E.; Blobel, C.P.; Himanen, J.P.; Lackmann, M.; Nikolov, D.B.
Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans
Cell
123
291-304
2005
Bos taurus
Manually annotated by BRENDA team
McCulloch, D.R.; Akl, P.; Samaratunga, H.; Herington, A.C.; Odorico, D.M.
Expression of the disintegrin metalloprotease, ADAM-10, in prostate cancer and its regulation by dihydrotestosterone, insulin-like growth factor I, and epidermal growth factor in the prostate cancer cell model LNCaP
Clin. Cancer Res.
10
314-323
2004
Homo sapiens
Manually annotated by BRENDA team
Ludwig, A.; Hundhausen, C.; Lambert, M.H.; Broadway, N.; Andrews, R.C.; Bickett, D.M.; Leesnitzer, M.A.; Becherer, J.D.
Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules
Comb. Chem. High Throughput Screen.
8
161-171
2005
Homo sapiens
Manually annotated by BRENDA team
Asayesh, A.; Alanentalo, T.; Khoo, N.K.; Ahlgren, U.
Developmental expression of metalloproteases ADAM 9, 10, and 17 becomes restricted to divergent pancreatic compartments
Dev. Dyn.
232
1105-1114
2005
Mus musculus
Manually annotated by BRENDA team
Reiss, K.; Maretzky, T.; Ludwig, A.; Tousseyn, T.; de Strooper, B.; Hartmann, D.; Saftig, P.
ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling
EMBO J.
24
742-752
2005
Mus musculus
Manually annotated by BRENDA team
Allinson, T.M.; Parkin, E.T.; Condon, T.P.; Schwager, S.L.; Sturrock, E.D.; Turner, A.J.; Hooper, N.M.
The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein
Eur. J. Biochem.
271
2539-2547
2004
Homo sapiens
Manually annotated by BRENDA team
Sanderson, M.P.; Erickson, S.N.; Gough, P.J.; Garton, K.J.; Wille, P.T.; Raines, E.W.; Dunbar, A.J.; Dempsey, P.J.
ADAM10 mediates ectodomain shedding of the betacellulin precursor activated by p-aminophenylmercuric acetate and extracellular calcium influx
J. Biol. Chem.
280
1826-1837
2005
Mus musculus
Manually annotated by BRENDA team
Obregon, D.F.; Rezai-Zadeh, K.; Bai, Y.; Sun, N.; Hou, H.; Ehrhart, J.; Zeng, J.; Mori, T.; Arendash, G.W.; Shytle, D.; Town, T.; Tan, J.
ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced a-secretase cleavage of amyloid precursor protein
J. Biol. Chem.
281
16419-16427
2006
Mus musculus
Manually annotated by BRENDA team
Reiss, K.; Maretzky, T.; Haas, I.G.; Schulte, M.; Ludwig, A.; Frank, M.; Saftig, P.
Regulated ADAM10-dependent ectodomain shedding of gamma-protocadherin C3 modulates cell-cell adhesion
J. Biol. Chem.
281
21735-21744
2006
Mus musculus
Manually annotated by BRENDA team
Zimmermann, M.; Gardoni, F.; Marcello, E.; Colciaghi, F.; Borroni, B.; Padovani, A.; Cattabeni, F.; Di Luca, M.
Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines
J. Neurochem.
90
1489-1499
2004
Homo sapiens
Manually annotated by BRENDA team
Bandyopadhyay, S.; Hartley, D.M.; Cahill, C.M.; Lahiri, D.K.; Chattopadhyay, N.; Rogers, J.T.
Interleukin-1alpha stimulates non-amyloidogenic pathway by alpha-secretase (ADAM-10 and ADAM-17) cleavage of APP in human astrocytic cells involving p38 MAP kinase
J. Neurosci. Res.
84
106-118
2006
Homo sapiens
Manually annotated by BRENDA team
Budagian, V.; Bulanova, E.; Orinska, Z.; Duitman, E.; Brandt, K.; Ludwig, A.; Hartmann, D.; Lemke, G.; Saftig, P.; Bulfone-Paus, S.
Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum
Mol. Cell. Biol.
25
9324-9339
2005
Mus musculus
Manually annotated by BRENDA team
Anders, L.; Mertins, P.; Lammich, S.; Murgia, M.; Hartmann, D.; Saftig, P.; Haass, C.; Ullrich, A.
Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenins transcriptional activity
Mol. Cell. Biol.
26
3917-3934
2006
Mus musculus
Manually annotated by BRENDA team
Uemura, K.; Kihara, T.; Kuzuya, A.; Okawa, K.; Nishimoto, T.; Ninomiya, H.; Sugimoto, H.; Kinoshita, A.; Shimohama, S.
Characterization of sequential N-cadherin cleavage by ADAM10 and PS1
Neurosci. Lett.
402
278-283
2006
Homo sapiens
Manually annotated by BRENDA team
Maretzky, T.; Reiss, K.; Ludwig, A.; Buchholz, J.; Scholz, F.; Proksch, E.; de Strooper, B.; Hartmann, D.; Saftig, P.
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation
Proc. Natl. Acad. Sci. USA
102
9182-9187
2005
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Schramme, A.; Abdel-Bakky, M.S.; Kaempfer-Kolb, N.; Pfeilschifter, J.; Gutwein, P.
The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells
Biochem. Biophys. Res. Commun.
370
311-316
2008
Homo sapiens
Manually annotated by BRENDA team
Ko, S.; Lin, S.; Wong, Y.; Liu, C.; Chang, K.; Liu, T.
Increase of disintegrin and metalloprotease 10 (ADAM10) expression in oral squamous cell carcinoma
Cancer Lett.
245
33-43
2007
Homo sapiens
Manually annotated by BRENDA team
Gavert, N.; Sheffer, M.; Raveh, S.; Spaderna, S.; Shtutman, M.; Brabletz, T.; Barany, F.; Paty, P.; Notterman, D.; Domany, E.; Ben-Zeev, A.
Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis
Cancer Res.
67
7703-7712
2007
Homo sapiens
Manually annotated by BRENDA team
Smith, C.; Halvorsen, B.; Otterdal, K.; Waehre, T.; Yndestad, A.; Fevang, B.; Sandberg, W.J.; Breland, U.M.; Froland, S.S.; Oie, E.; Gullestad, L.; Damas, J.K.; Aukrust, P.
High levels and inflammatory effects of soluble CXC ligand 16 (CXCL16) in coronary artery disease: down-regulatory effects of statins
Cardiovasc. Res.
79
195-203
2008
Homo sapiens
Manually annotated by BRENDA team
Schulte, M.; Reiss, K.; Lettau, M.; Maretzky, T.; Ludwig, A.; Hartmann, D.; de Strooper, B.; Janssen, O.; Saftig, P.
ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death
Cell Death Differ.
14
1040-1049
2007
Homo sapiens
Manually annotated by BRENDA team
Conrad, D.H.; Ford, J.W.; Sturgill, J.L.; Gibb, D.R.
CD23: an overlooked regulator of allergic disease
Curr. Allergy Asthma Rep.
7
331-337
2007
Homo sapiens
Manually annotated by BRENDA team
Deuss, M.; Reiss, K.; Hartmann, D.
Part-time alpha-secretases: the functional biology of ADAM 9, 10 and 17
Curr. Alzheimer Res.
5
187-201
2008
Drosophila melanogaster, Mus musculus
Manually annotated by BRENDA team
Hakulinen, J.; Keski-Oja, J.
ADAM10-mediated release of complement membrane cofactor protein during apoptosis of epithelial cells
J. Biol. Chem.
281
21369-21376
2006
Homo sapiens
Manually annotated by BRENDA team
Lemieux, G.A.; Blumenkron, F.; Yeung, N.; Zhou, P.; Williams, J.; Grammer, A.C.; Petrovich, R.; Lipsky, P.E.; Moss, M.L.; Werb, Z.
The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10
J. Biol. Chem.
282
14836-14844
2007
Homo sapiens
Manually annotated by BRENDA team
Moss, M.L.; Bomar, M.; Liu, Q.; Sage, H.; Dempsey, P.; Lenhart, P.M.; Gillispie, P.A.; Stoeck, A.; Wildeboer, D.; Bartsch, J.W.; Palmisano, R.; Zhou, P.
The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events
J. Biol. Chem.
282
35712-35721
2007
Mus musculus
Manually annotated by BRENDA team
Martin, L.; Fluhrer, R.; Reiss, K.; Kremmer, E.; Saftig, P.; Haass, C.
Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b
J. Biol. Chem.
283
1644-1652
2008
Homo sapiens
Manually annotated by BRENDA team
Kaczur, V.; Puskas, L.G.; Nagy, Z.U.; Miled, N.; Rebai, A.; Juhasz, F.; Kupihar, Z.; Zvara, A.; Hackler, L.J.; Farid, N.R.
Cleavage of human thyrotropin receptor by ADAM10 is regulated by thyrotropin
J. Mol. Recognit.
20
392-404
2007
Homo sapiens (O14672), Homo sapiens
Manually annotated by BRENDA team
Albrecht, S.; Wang, S.; Holz, A.; Bergter, A.; Paululat, A.
The ADAM metalloprotease Kuzbanian is crucial for proper heart formation in Drosophila melanogaster
Mech. Dev.
123
372-387
2006
Drosophila melanogaster, Drosophila melanogaster Oregon R
Manually annotated by BRENDA team
Dehmel, T.; Janke, A.; Hartung, H.P.; Goebel, H.H.; Wiendl, H.; Kieseier, B.C.
The cell-specific expression of metalloproteinase-disintegrins (ADAMs) in inflammatory myopathies
Neurobiol. Dis.
25
665-674
2007
Homo sapiens
Manually annotated by BRENDA team
Clement, A.B.; Hanstein, R.; Schroeder, A.; Nagel, H.; Endres, K.; Fahrenholz, F.; Behl, C.
Effects of neuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress
Neuroscience
152
459-468
2008
Mus musculus
Manually annotated by BRENDA team
Chen, C.D.; Podvin, S.; Gillespie, E.; Leeman, S.E.; Abraham, C.R.
Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17
Proc. Natl. Acad. Sci. USA
104
19796-19801
2007
Homo sapiens
Manually annotated by BRENDA team
Rapti, M.; Atkinson, S.J.; Lee, M.H.; Trim, A.; Moss, M.; Murphy, G.
The isolated N-terminal domains of TIMP-1 and TIMP-3 are insufficient for ADAM10 inhibition
Biochem. J.
411
433-439
2008
Homo sapiens
Manually annotated by BRENDA team
Escrevente, C.; Morais, V.A.; Keller, S.; Soares, C.M.; Altevogt, P.; Costa, J.
Functional role of N-glycosylation from ADAM10 in processing, localization and activity of the enzyme
Biochim. Biophys. Acta
1780
905-913
2008
Bos taurus, Homo sapiens
Manually annotated by BRENDA team
Esselens, C.W.; Malapeira, J.; Colome, N.; Moss, M.; Canals, F.; Arribas, J.
Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17
Biol. Chem.
389
1075-1084
2008
Homo sapiens
Manually annotated by BRENDA team
Prinzen, C.; Truembach, D.; Wurst, W.; Endres, K.; Postina, R.; Fahrenholz, F.
Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice
BMC Genomics
10
66
2009
Bos taurus
Manually annotated by BRENDA team
Schulz, B.; Pruessmeyer, J.; Maretzky, T.; Ludwig, A.; Blobel, C.P.; Saftig, P.; Reiss, K.
ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin
Circ. Res.
102
1192-1201
2008
Homo sapiens
Manually annotated by BRENDA team
Raucci, A.; Cugusi, S.; Antonelli, A.; Barabino, S.M.; Monti, L.; Bierhaus, A.; Reiss, K.; Saftig, P.; Bianchi, M.E.
A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10)
FASEB J.
22
3716-3727
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Freese, C.; Garratt, A.N.; Fahrenholz, F.; Endres, K.
The effects of alpha-secretase ADAM10 on the proteolysis of neuregulin-1
FEBS J.
276
1568-1580
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Oh, S.T.; Schramme, A.; Stark, A.; Tilgen, W.; Gutwein, P.; Reichrath, J.
The disintegrin-metalloproteinases ADAM 10, 12 and 17 are upregulated in invading peripheral tumor cells of basal cell carcinomas
J. Cutan. Pathol.
36
395-401
2009
Homo sapiens
Manually annotated by BRENDA team
Arduise, C.; Abache, T.; Li, L.; Billard, M.; Chabanon, A.; Ludwig, A.; Mauduit, P.; Boucheix, C.; Rubinstein, E.; Le Naour, F.
Tetraspanins regulate ADAM10-mediated cleavage of TNF-alpha and epidermal growth factor
J. Immunol.
181
7002-7013
2008
Homo sapiens
Manually annotated by BRENDA team
Parkin, E.; Harris, B.
A disintegrin and metalloproteinase (ADAM)-mediated ectodomain shedding of ADAM10
J. Neurochem.
108
1464-1479
2009
Homo sapiens
Manually annotated by BRENDA team
Kohutek, Z.A.; diPierro, C.G.; Redpath, G.T.; Hussaini, I.M.
ADAM-10-mediated N-cadherin cleavage is protein kinase C-alpha dependent and promotes glioblastoma cell migration
J. Neurosci.
29
4605-4615
2009
Mus musculus
Manually annotated by BRENDA team
Dehmel, T.; Goebel, H.H.; Hartung, H.P.; Lehmann, H.; Wiendl, H.; Kieseier, B.C.
The metalloproteinase-disintegrin ADAM10 is exclusively expressed by type I muscle fibers
Muscle Nerve
38
1049-1051
2008
Homo sapiens
Manually annotated by BRENDA team
Qin, W.; Ho, L.; Wang, J.; Peskind, E.; Pasinetti, G.M.
S100A7, a novel Alzheimers disease biomarker with non-amyloidogenic alpha-secretase activity acts via selective promotion of ADAM-10
PLoS ONE
4
e4183
2009
Homo sapiens
Manually annotated by BRENDA team
Riedle, S.; Kiefel, H.; Gast, D.; Bondong, S.; Wolterink, S.; Gutwein, P.; Altevogt, P.
Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity
Biochem. J.
420
391-402
2009
Homo sapiens
Manually annotated by BRENDA team
Caescu, C.I.; Jeschke, G.R.; Turk, B.E.
Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10
Biochem. J.
424
79-88
2009
Mus musculus
Manually annotated by BRENDA team
Dittmer, A.; Hohlfeld, K.; Luetzkendorf, J.; Mueller, L.P.; Dittmer, J.
Human mesenchymal stem cells induce E-cadherin degradation in breast carcinoma spheroids by activating ADAM10
Cell. Mol. Life Sci.
66
3053-3065
2009
Homo sapiens
Manually annotated by BRENDA team
Mezyk-Kopec R.; Bzowska, M.; Stalinska, K.; Chelmicki, T.; Podkalicki, M.; Jucha, J.; Kowalczyk, K.; Mak, P.; Bereta, J.
Identification of ADAM10 as a major TNF sheddase in ADAM17-deficient fibroblasts
Cytokine
46
309-315
2009
Mus musculus
Manually annotated by BRENDA team
Oh, S.T.; Cho, B.K.; Schramme, A.; Gutwein, P.; Tilgen, W.; Reichrath, J.
Hair-cycle dependent differential expression of ADAM 10 and ADAM 12: An immunohistochemical analysis in human hair follicles in situ
Dermatoendocrinol.
1
46-53
2009
Homo sapiens
Manually annotated by BRENDA team
Tippmann, F.; Hundt, J.; Schneider, A.; Endres, K.; Fahrenholz, F.
Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin
FASEB J.
23
1643-1654
2009
Homo sapiens
Manually annotated by BRENDA team
Xu, D.; Sharma, C.; Hemler, M.E.
Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein
FASEB J.
23
3674-3681
2009
Homo sapiens
Manually annotated by BRENDA team
Endres, K.; Fahrenholz, F.
Upregulation of the alpha-secretase ADAM10--risk or reason for hope?
FEBS J.
277
1585-1596
2010
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Kim, M.; Suh, J.; Romano, D.; Truong, M.H.; Mullin, K.; Hooli, B.; Norton, D.; Tesco, G.; Elliott, K.; Wagner, S.L.; Moir, R.D.; Becker, K.D.; Tanzi, R.E.
Potential late-onset Alzheimers disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity
Hum. Mol. Genet.
18
3987-3996
2009
Homo sapiens
Manually annotated by BRENDA team
Peng, M.; Guo, S.; Yin, N.; Xue, J.; Shen, L.; Zhao, Q.; Zhang, W.
Ectodomain shedding of Fcalpha receptor is mediated by ADAM10 and ADAM17
Immunology
130
83-91
2010
Homo sapiens
Manually annotated by BRENDA team
Tousseyn, T.; Thathiah, A.; Jorissen, E.; Raemaekers, T.; Konietzko, U.; Reiss, K.; Maes, E.; Snellinx, A.; Serneels, L.; Nyabi, O.; Annaert, W.; Saftig, P.; Hartmann, D.; De Strooper, B.
ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase
J. Biol. Chem.
284
11738-11747
2009
Mus musculus (O35598)
Manually annotated by BRENDA team
Franzke, C.W.; Bruckner-Tuderman, L.; Blobel, C.P.
Shedding of collagen XVII/BP180 in skin depends on both ADAM10 and ADAM9
J. Biol. Chem.
284
23386-23396
2009
Mus musculus
Manually annotated by BRENDA team
van Tetering, G.; van Diest, P.; Verlaan, I.; van der Wall, E.; Kopan, R.; Vooijs, M.
Metalloprotease ADAM10 is required for Notch1 site 2 cleavage
J. Biol. Chem.
284
31018-31027
2009
Mus musculus
Manually annotated by BRENDA team
Marcello, E.; Gardoni, F.; Di Luca, M.; Perez-Otano, I.
An arginine stretch limits ADAM10 exit from the endoplasmic reticulum
J. Biol. Chem.
285
10376-10384
2010
Mus musculus
Manually annotated by BRENDA team
Ratchford, A.M.; Baker, O.J.; Camden, J.M.; Rikka, S.; Petris, M.J.; Seye, C.I.; Erb, L.; Weisman, G.A.
P2Y2 nucleotide receptors mediate metalloprotease-dependent phosphorylation of epidermal growth factor receptor and ErbB3 in human salivary gland cells
J. Biol. Chem.
285
7545-7555
2010
Homo sapiens
Manually annotated by BRENDA team
Jorissen, E.; Prox, J.; Bernreuther, C.; Weber, S.; Schwanbeck, R.; Serneels, L.; Snellinx, A.; Craessaerts, K.; Thathiah, A.; Tesseur, I.; Bartsch, U.; Weskamp, G.; Blobel, C.P.; Glatzel, M.; De Strooper, B.; Saftig, P.
The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex
J. Neurosci.
30
4833-4844
2010
Mus musculus
Manually annotated by BRENDA team
Le Gall, S.M.; Bobe, P.; Reiss, K.; Horiuchi, K.; Niu, X.D.; Lundell, D.; Gibb, D.R.; Conrad, D.; Saftig, P.; Blobel, C.P.
ADAMs 10 and 17 represent differentially regulated components of a general shedding machinery for membrane proteins such as transforming growth factor alpha, L-selectin, and tumor necrosis factor alpha
Mol. Biol. Cell
20
1785-1794
2009
Mus musculus
Manually annotated by BRENDA team
Bozkulak, E.C.; Weinmaster, G.
Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling
Mol. Cell. Biol.
29
5679-5695
2009
Mus musculus
Manually annotated by BRENDA team
Endres, K.; Mitteregger, G.; Kojro, E.; Kretzschmar, H.; Fahrenholz, F.
Influence of ADAM10 on prion protein processing and scrapie infectiosity in vivo
Neurobiol. Dis.
36
233-241
2009
Mus musculus
Manually annotated by BRENDA team
Janes, P.W.; Wimmer-Kleikamp, S.H.; Frangakis, A.S.; Treble, K.; Griesshaber, B.; Sabet, O.; Grabenbauer, M.; Ting, A.Y.; Saftig, P.; Bastiaens, P.I.; Lackmann, M.
Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10
PLoS Biol.
7
e1000215
2009
Mus musculus
Manually annotated by BRENDA team
Jacobsen, K.T.; Adlerz, L.; Multhaup, G.; Iverfeldt, K.
Insulin-like growth factor-1 (IGF-1)-induced processing of amyloid-beta precursor protein (APP) and APP-like protein 2 is mediated by different metalloproteinases
J. Biol. Chem.
285
10223-10231
2010
Homo sapiens
Manually annotated by BRENDA team
Endres, K.; Fahrenholz, F.
Regulation of alpha-secretase ADAM10 expression and activity
Exp. Brain Res.
2011
1-10
2011
Homo sapiens
-
Manually annotated by BRENDA team
Kim, J.; Lilliehook, C.; Dudak, A.; Prox, J.; Saftig, P.; Federoff, H.J.; Lim, S.T.
Activity-dependent alpha-cleavage of nectin-1 is mediated by a disintegrin and metalloprotease 10 (ADAM10)
J. Biol. Chem.
285
22919-22926
2010
Mus musculus
Manually annotated by BRENDA team
Garbers, C.; Jaenner, N.; Chalaris, A.; Moss, M.L.; Floss, D.M.; Meyer, D.; Koch-Nolte, F.; Rose-John, S.; Scheller, J.
Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding
J. Biol. Chem.
286
14804-14811
2011
Mus musculus
Manually annotated by BRENDA team
Bouillot, S.; Tillet, E.; Carmona, G.; Prandini, M.H.; Gauchez, A.S.; Hoffmann, P.; Alfaidy, N.; Cand, F.; Huber, P.
Protocadherin-12 cleavage is a regulated process mediated by ADAM10 protein: evidence of shedding up-regulation in pre-eclampsia
J. Biol. Chem.
286
15195-15204
2011
Homo sapiens
Manually annotated by BRENDA team
Gibb, D.R.; El Shikh, M.; Kang, D.J.; Rowe, W.J.; El Sayed, R.; Cichy, J.; Yagita, H.; Tew, J.G.; Dempsey, P.J.; Crawford, H.C.; Conrad, D.H.
ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo
J. Exp. Med.
207
623-635
2010
Mus musculus
Manually annotated by BRENDA team
Chaimowitz, N.S.; Martin, R.K.; Cichy, J.; Gibb, D.R.; Patil, P.; Kang, D.J.; Farnsworth, J.; Butcher, E.C.; McCright, B.; Conrad, D.H.
A disintegrin and metalloproteinase 10 regulates antibody production and maintenance of lymphoid architecture
J. Immunol.
187
5114-5122
2011
Mus musculus
Manually annotated by BRENDA team
Blume, K.E.; Soeroes, S.; Keppeler, H.; Stevanovic, S.; Kretschmer, D.; Rautenberg, M.; Wesselborg, S.; Lauber, K.
Cleavage of annexin A1 by ADAM10 during secondary necrosis generates a monocytic find-me signal
J. Immunol.
188
135-145
2012
Homo sapiens
Manually annotated by BRENDA team
Malinverno, M.; Carta, M.; Epis, R.; Marcello, E.; Verpelli, C.; Cattabeni, F.; Sala, C.; Mulle, C.; Di Luca, M.; Gardoni, F.
Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage
J. Neurosci.
30
16343-16355
2010
Mus musculus
Manually annotated by BRENDA team
Solanas, G.; Cortina, C.; Sevillano, M.; Batlle, E.
Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling
Nat. Cell Biol.
13
1100-1107
2011
Canis lupus familiaris
Manually annotated by BRENDA team
Hogl, S.; Kuhn, P.H.; Colombo, A.; Lichtenthaler, S.F.
Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and gamma-secretase
PLoS ONE
6
e21337
2011
Homo sapiens
Manually annotated by BRENDA team
Nagara, Y.; Hagiyama, M.; Hatano, N.; Futai, E.; Suo, S.; Takaoka, Y.; Murakami, Y.; Ito, A.; Ishiura, S.
Tumor suppressor cell adhesion molecule 1 (CADM1) is cleaved by a disintegrin and metalloprotease 10 (ADAM10) and subsequently cleaved by gamma-secretase complex
Biochem. Biophys. Res. Commun.
417
462-467
2012
Homo sapiens (O14672)
Manually annotated by BRENDA team
Pabois, A.; Devalliere, J.; Quillard, T.; Coulon, F.; Gerard, N.; Laboisse, C.; Toquet, C.; Charreau, B.
The disintegrin and metalloproteinase ADAM10 mediates a canonical Notch-dependent regulation of IL-6 through Dll4 in human endothelial cells
Biochem. Pharmacol.
91
510-521
2014
Homo sapiens (O14672), Homo sapiens
Manually annotated by BRENDA team
Urriola-Munoz, P.; Lizama, C.; Lagos-Cabre, R.; Reyes, J.; Moreno, R.
Differential expression and localization of ADAM10 and ADAM17 during rat spermatogenesis suggest a role in germ cell differentiation
Biol. Res.
47
31
2014
Rattus norvegicus (Q10743)
Manually annotated by BRENDA team
Tsai, Y.; Vandussen, K.; Sawey, E.; Wade, A.; Kasper, C.; Rakshit, S.; Bhatt, R.; Stoeck, A.; Maillard, I.; Crawford, H.; Samuelson, L.; Dempsey, P.
ADAM10 regulates notch function in intestinal stem cells of mice
Gastroenterology
147
822-834.e13
2014
Mus musculus
Manually annotated by BRENDA team
Guo, Q.; Wang, Y.; Tripathi, P.; Manda, K.; Mukherjee, M.; Chaklader, M.; Austin, P.; Surendran, K.; Chen, F.
Adam10 mediates the choice between principal cells and intercalated cells in the kidney
J. Am. Soc. Nephrol.
26
149-159
2015
Mus musculus
Manually annotated by BRENDA team
Breshears, L.M.; Schlievert, P.M.; Peterson, M.L.
A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1)
J. Biol. Chem.
287
32578-32587
2012
Homo sapiens (O14672), Homo sapiens
Manually annotated by BRENDA team
Minond, D.; Cudic, M.; Bionda, N.; Giulianotti, M.; Maida, L.; Houghten, R.; Fields, G.
Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates
J. Biol. Chem.
287
36473-36487
2012
Homo sapiens (O14672)
Manually annotated by BRENDA team
Herzog, C.; Haun, R.S.; Ludwig, A.; Shah, S.V.; Kaushal, G.P.
ADAM10 is the major sheddase responsible for the release of membrane-associated meprin A
J. Biol. Chem.
289
13308-13322
2014
Mus musculus (O35598)
Manually annotated by BRENDA team
Powers, M.; Kim, H.; Wang, Y.; Wardenburg, J.
ADAM10 mediates vascular injury induced by Staphylococcus aureus alpha-hemolysin
J. Infect. Dis.
206
352-356
2012
Mus musculus (O35598), Mus musculus
Manually annotated by BRENDA team
Hofmann, S.; Vgtle, T.; Bender, M.; Rose-John, S.; Nieswandt, B.
The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets
J. Thromb. Haemost.
10
2581-2592
2012
Homo sapiens (O14672), Mus musculus (O35598)
Manually annotated by BRENDA team
Shitomi, Y.; Thogersen, I.; Ito, N.; Leitinger, B.; Enghild, J.; Itoh, Y.
ADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1)
Mol. Biol. Cell
26
659-673
2015
Homo sapiens (O14672)
Manually annotated by BRENDA team
Chaimowitz, N.; Kang, D.; Dean, L.; Conrad, D.
ADAM10 regulates transcription factor expression required for plasma cell function
PLoS ONE
7
e42694
2012
Mus musculus (O35598)
Manually annotated by BRENDA team
Raikwar, N.; Liu, K.; Thomas, C.
N-terminal cleavage and release of the ectodomain of Flt1 is mediated via ADAM10 and ADAM 17 and regulated by VEGFR2 and the Flt1 intracellular domain
PLoS ONE
9
e112794
2014
Homo sapiens (O14672)
Manually annotated by BRENDA team
Loreto, C.; Chiarenza, G.P.; Musumeci, G.; Castrogiovanni, P.; Imbesi, R.; Ruggeri, A.; Almeida, L.E.; Leonardi, R.
ADAM10 localization in temporomandibular joint disk with internal derangement an ex vivo immunohistochemical study
Acta Histochem.
118
293-298
2016
Homo sapiens
Manually annotated by BRENDA team
Tan, Y.; Fu, R.; Liu, J.; Wu, Y.; Wang, B.; Jiang, N.; Nie, P.; Cao, H.; Yang, Z.; Fang, B.
ADAM10 is essential for cranial neural crest-derived maxillofacial bone development
Biochem. Biophys. Res. Commun.
475
308-314
2016
Mus musculus (O35598), Mus musculus
Manually annotated by BRENDA team
von Hoven, G.; Rivas, A.J.; Neukirch, C.; Klein, S.; Hamm, C.; Qin, Q.; Meyenburg, M.; Fueser, S.; Saftig, P.; Hellmann, N.; Postina, R.; Husmann, M.
Dissecting the role of ADAM10 as a mediator of Staphylococcus aureus alpha-toxin action
Biochem. J.
473
1929-1940
2016
Homo sapiens (O14672), Homo sapiens
Manually annotated by BRENDA team
Pabois, A.; Devalliere, J.; Quillard, T.; Coulon, F.; Gerard, N.; Laboisse, C.; Toquet, C.; Charreau, B.
The disintegrin and metalloproteinase ADAM10 mediates a canonical Notch-dependent regulation of IL-6 through Dll4 in human endothelial cells
Biochem. Pharmacol.
91
510-521
2015
Homo sapiens (O14672), Homo sapiens
Manually annotated by BRENDA team
Dempsey, P.J.
Role of ADAM10 in intestinal crypt homeostasis and tumorigenesis
Biochim. Biophys. Acta Mol. Cell Res.
1864
2228-2239
2017
Mus musculus
Manually annotated by BRENDA team
Vincent, B.
Regulation of the alpha-secretase ADAM10 at transcriptional, translational and post-translational levels
Brain Res. Bull.
126
154-169
2016
Homo sapiens (O14672)
Manually annotated by BRENDA team
You, B.; Shan, Y.; Shi, S.; Li, X.; You, Y.
Effects of ADAM10 upregulation on progression, migration, and prognosis of nasopharyngeal carcinoma
Cancer Sci.
106
1506-1514
2015
Homo sapiens (O14672), Homo sapiens
Manually annotated by BRENDA team
Altmeppen, H.C.; Prox, J.; Krasemann, S.; Puig, B.; Kruszewski, K.; Dohler, F.; Bernreuther, C.; Hoxha, A.; Linsenmeier, L.; Sikorska, B.; Liberski, P.P.; Bartsch, U.; Saftig, P.; Glatzel, M.
The sheddase ADAM10 is a potent modulator of prion disease
eLife
4
e04260
2015
Mus musculus (O35598)
Manually annotated by BRENDA team
Kuhn, P.H.; Colombo, A.V.; Schusser, B.; Dreymueller, D.; Wetzel, S.; Schepers, U.; Herber, J.; Ludwig, A.; Kremmer, E.; Montag, D.; Mueller, U.; Schweizer, M.; Saftig, P.; Braese, S.; Lichtenthaler, S.F.
Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function
eLife
5
e12748
2016
Mus musculus (O35598), Mus musculus
Manually annotated by BRENDA team
Endres, K.; Deller, T.
Regulation of alpha-secretase ADAM10 in vitro and in vivo Genetic, epigenetic, and protein-based mechanisms
Front. Mol. Neurosci.
10
56
2017
Homo sapiens (O14672), Homo sapiens
Manually annotated by BRENDA team
Ruiz-Arroyo, V.M.; Garcia-Robles, I.; Ochoa-Campuzano, C.; Goig, G.A.; Zaitseva, E.; Baaken, G.; Martinez-Ramirez, A.C.; Rausell, C.; Real, M.D.
Validation of ADAM10 metalloprotease as a Bacillus thuringiensis Cry3Aa toxin functional receptor in Colorado potato beetle (Leptinotarsa decemlineata)
Insect Mol. Biol.
26
204-214
2017
Leptinotarsa decemlineata (A0A1L2JAW4), Leptinotarsa decemlineata
Manually annotated by BRENDA team
Lundgren, J.L.; Ahmed, S.; Schedin-Weiss, S.; Gouras, G.K.; Winblad, B.; Tjernberg, L.O.; Frykman, S.
ADAM10 and BACE1 are localized to synaptic vesicles
J. Neurochem.
135
606-615
2015
Rattus norvegicus (O10743)
Manually annotated by BRENDA team
Siney, E.J.; Holden, A.; Casselden, E.; Bulstrode, H.; Thomas, G.J.; Willaime-Morawek, S.
Metalloproteinases ADAM10 and ADAM17 mediate migration and differentiation in glioblastoma sphere-forming cells
Mol. Neurobiol.
54
3893-3905
2017
Homo sapiens (O14672), Homo sapiens
Manually annotated by BRENDA team
Madoux, F.; Dreymuller, D.; Pettiloud, J.P.; Santos, R.; Becker-Pauly, C.; Ludwig, A.; Fields, G.B.; Bannister, T.; Spicer, T.P.; Cudic, M.; Scampavia, L.D.; Minond, D.
Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate
Sci. Rep.
6
11
2016
Homo sapiens (O14672)
Manually annotated by BRENDA team
Riethmueller, S.; Ehlers, J.C.; Lokau, J.; Duesterhoeft, S.; Knittler, K.; Dombrowsky, G.; Groetzinger, J.; Rabe, B.; Rose-John, S.; Garbers, C.
Cleavage site localization differentially controls interleukin-6 receptor proteolysis by ADAM10 and ADAM17
Sci. Rep.
6
25550
2016
Homo sapiens (O14672)
Manually annotated by BRENDA team
Folkesson, M.; Li, C.; Frebelius, S.; Swedenborg, J.; Wagsaeter, D.; Williams, K.J.; Eriksson, P.; Roy, J.; Liu, M.L.
Proteolytically active ADAM10 and ADAM17 carried on membrane microvesicles in human abdominal aortic aneurysms
Thromb. Haemost.
114
1165-1174
2015
Homo sapiens
Manually annotated by BRENDA team