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Information on EC 3.4.24.35 - gelatinase B and Organism(s) Homo sapiens

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.35 gelatinase B
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Select one or more organisms in this record: ?
This record set is specific for:
Homo sapiens
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Cleavage of gelatin types I and V and collagen types IV and V
Synonyms
mmp-9, matrix metalloproteinase-9, matrix metalloproteinase 9, gelatinase b, matrix metallopeptidase 9, matrix metalloprotease-9, mmp 9, 92-kda gelatinase, 92 kda gelatinase, 92-kda type iv collagenase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
92 kDa gelatinase
92 kDa type IV collagenase
-
-
92 kDa type IV collagenase proMMP-9
-
-
92-kDa Gelatinase
-
-
-
-
92-kDa gelatinase B
-
-
92-kDa Type IV collagenase
95 kDa type IV collagenase/gelatinase
-
-
-
-
Collagenase IV
-
-
-
-
Collagenase type IV
-
-
-
-
gelatinase
-
gelatinase B
Gelatinase MMP 9
-
-
-
-
GELB
-
-
-
-
Macrophage gelatinase
-
-
-
-
matrix metallopeptidase 9
matrix metallopeptidase 9 gelatinase B
-
-
matrix metalloprotease-9
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-
Matrix metalloproteinase 9
matrix metalloproteinase-9
metrix metalloproteinase-9
-
-
MMP 9
MMP-9
neutrophil collagenase
-
-
pro-matrix metalloproteinase-9
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-
progelatinase
-
Type IV collagen metalloproteinase
-
-
-
-
Type IV collagenase
Type IV collagenase/gelatinase
Type V collagenase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
146480-36-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(7-methoxycoumarin-4-yl)-acetyl-Pro-Leu-Gly-Leu-(3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-Ala-Arg-NH2 + H2O
?
show the reaction diagram
-
-
-
-
?
(7-methoxycoumaryl-4yl)acetylPLGLA2pr(2,4-dinitrophenol)-AR-NH2 + H2O
?
show the reaction diagram
-
-
?
2,4-dinitrophenyl-Pro-beta-cyclohexylalanyl-Gly-Cys(Me)-His-Ala-Lys(N-Me-2-aminobenzoyl)-NH2 + H2O
?
show the reaction diagram
-
a quenched fluorogenic substrate
-
-
?
2,4-Dinitrophenyl-Pro-Leu-Gly-Leu-Trp-Ala-D-Arg-NH2 + H2O
2,4-Dinitrophenyl-Pro-Leu-Gly + Leu-Trp-Ala-D-Arg-NH2
show the reaction diagram
-
and peptide substrates derived from, utility of substrate mapping form examining the subsite specificities and the optimization of proteinase substrates
-
?
65000 MW form of vitronectin + H2O
?
show the reaction diagram
-
-
-
-
?
Ac-L-Pro-L-Pro(OH)-Gly-L-Gln-Gly-L-Ala-L-Thr-Gly-L-Glu-L-Pro(OH)-Gly-NH2 + H2O
?
show the reaction diagram
-
-
-
-
?
actin + H2O
?
show the reaction diagram
-
-
-
-
?
Aggrecan core protein + H2O
?
show the reaction diagram
-
-
-
-
?
alpha-enolase + H2O
?
show the reaction diagram
-
-
-
-
?
annexin I + H2O
?
show the reaction diagram
-
-
-
-
?
Arp2/3 complex subunit + H2O
?
show the reaction diagram
-
-
-
-
?
betaB1 crystallin + H2O
?
show the reaction diagram
-
main enzyme substrate in lens extract
-
-
?
citrate synthase + H2O
?
show the reaction diagram
-
-
-
-
?
Collagen + H2O
?
show the reaction diagram
Collagen type I + H2O
?
show the reaction diagram
Collagen type III + H2O
?
show the reaction diagram
collagen type IV + H2O
?
show the reaction diagram
collagen type V + H2O
?
show the reaction diagram
-
-
-
-
?
collagen type XI + H2O
?
show the reaction diagram
-
-
-
-
?
DNP-Pro-cyclohexyl-Ala-Gly-Cys(Me)-His-Ala-Lys(N-Me-Abz)-NH2 + H2O
DNP-Pro-cyclohexyl-Ala-Gly + Cys(Me)-His-Ala-Lys(N-Me-Abz)-NH2
show the reaction diagram
-
-
-
?
Elastin + H2O
?
show the reaction diagram
-
-
-
-
?
ephB1 + H2O
?
show the reaction diagram
-
-
-
?
epidermal growth factor + H2O
?
show the reaction diagram
ezrin + H2O
?
show the reaction diagram
-
-
-
-
?
fibrillar collagen + H2O
?
show the reaction diagram
filamin B + H2O
?
show the reaction diagram
-
-
-
-
?
fragments of human collagen type II + H2O
?
show the reaction diagram
-
fragments obtained by cleavage with collagenases MMP-1, MMP-8, or MMP-13. Enzyme produces small remnant peptides with still intact immunodominant epitopes
-
-
?
Galectin-3 + H2O
?
show the reaction diagram
Gelatin + H2O
?
show the reaction diagram
gelsolin + H2O
?
show the reaction diagram
-
-
-
-
?
heat shock protein 27 + H2O
?
show the reaction diagram
-
-
-
-
?
heat shock protein 70 + H2O
?
show the reaction diagram
-
-
-
-
?
heat shock protein 90 + H2O
?
show the reaction diagram
-
-
-
-
?
histidyl-tRNA synthetase + H2O
?
show the reaction diagram
-
-
-
-
?
HMGB1 protein + H2O
?
show the reaction diagram
-
-
-
-
?
islet amyloid polypeptide + H2O
?
show the reaction diagram
enzyme MMP-9 degrades amyloidogenic humanislet amyloid polypeptide but not nonamyloidogenic mouse islet amyloid polypeptide
-
-
?
L-Pro-L-Pro(OH)-Gly-L-Gln-Gly-L-Ala-L-Thr-Gly-L-Glu-L-Pro(OH)-Gly-NH2 + H2O
?
show the reaction diagram
-
-
-
-
?
Laminin + H2O
?
show the reaction diagram
-
-
-
-
?
LS276-THP + H2O
?
show the reaction diagram
-
development and evaluation of an activatable NIR fluorescent probe LS276-THP for in vivo detection of cancer-related matrix metalloproteinase activity based on a triplehelical peptide substrate with high specificity for MMP-2 and MMP-9 relative to other members of the MMP family, overview. Triple-helical peptides are suitable for highly specific in vivo detection of tumor-related MMP-2 and MMP-9 activity
-
-
?
Mca-KPLGL-(Dpa)-AR-NH2 + H2O
?
show the reaction diagram
-
-
-
?
moesin + H2O
?
show the reaction diagram
-
-
-
-
?
N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl-7-methoxycoumarin-4-yl acetyl + H2O
?
show the reaction diagram
-
-
-
?
N-alpha-benzoyl-arginine p-nitroanilide + H2O
N-alpha-benzoyl-Arg + 4-nitroaniline
show the reaction diagram
-
i.e. BAPNA
-
-
?
Neonatal human proteoglycan + H2O
?
show the reaction diagram
-
poor substrate, cleavage of the His16-Ile17 bond
-
-
?
nonmuscular actin + H2O
?
show the reaction diagram
-
-
-
?
nucleolin + H2O
?
show the reaction diagram
-
-
-
-
?
peptide A13 + H2O
?
show the reaction diagram
-
-
-
?
peptide A13R + H2O
?
show the reaction diagram
-
-
-
?
peptide A3 + H2O
?
show the reaction diagram
-
-
-
?
peptide A34 + H2O
?
show the reaction diagram
-
-
-
?
peptide B74 + H2O
?
show the reaction diagram
-
-
-
?
peptide C15 + H2O
?
show the reaction diagram
-
non-selective peptide substrate
-
?
peptide C9 + H2O
?
show the reaction diagram
-
-
-
?
peptide m1A11 + H2O
?
show the reaction diagram
-
non-selective peptide substrate
-
?
Proteoglycan + H2O
?
show the reaction diagram
-
-
-
-
?
snRNP D3 + H2O
?
show the reaction diagram
-
-
-
-
?
stathmin + H2O
?
show the reaction diagram
-
-
-
-
?
stromelysin 1 + H2O
?
show the reaction diagram
-
-
?
stromelysin1 + H2O
?
show the reaction diagram
-
-
-
?
succinylated gelatin + H2O
?
show the reaction diagram
-
-
-
-
?
tubulin + H2O
?
show the reaction diagram
-
-
-
-
?
Type IV collagen + H2O
?
show the reaction diagram
-
-
-
-
?
type V collagen + H2O
?
show the reaction diagram
-
-
-
-
?
type XI collagen + H2O
?
show the reaction diagram
-
-
-
-
?
Vitronectin + H2O
?
show the reaction diagram
-
65000 MW and 75000 MW form of vitronectin
-
-
?
vitronectin of MW 65000 + H2O
?
show the reaction diagram
-
-
-
-
?
vitronectin of MW 75000 + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
Aggrecan core protein + H2O
?
show the reaction diagram
-
-
-
-
?
Collagen + H2O
?
show the reaction diagram
-
MMP-9 inhibits collagen-induced platelet aggregation
-
-
?
Collagen type I + H2O
?
show the reaction diagram
-
-
-
-
?
Collagen type III + H2O
?
show the reaction diagram
-
-
-
-
?
collagen type IV + H2O
?
show the reaction diagram
-
-
-
-
?
collagen type V + H2O
?
show the reaction diagram
-
-
-
-
?
collagen type XI + H2O
?
show the reaction diagram
-
-
-
-
?
epidermal growth factor + H2O
?
show the reaction diagram
-
MMP-9 induces TGF-beta1 production in the airway epithelium through the cleavage of epidermal growth factor, EGF, and membrane-bound EGF-like ligands and activating epidermal growth factor receptor
-
-
?
fibrillar collagen + H2O
?
show the reaction diagram
Gelatin + H2O
?
show the reaction diagram
islet amyloid polypeptide + H2O
?
show the reaction diagram
enzyme MMP-9 degrades amyloidogenic humanislet amyloid polypeptide but not nonamyloidogenic mouse islet amyloid polypeptide
-
-
?
Laminin + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Calcium
-
required
Zinc
-
required
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2E)-3-(N-hydroxycarbamoyl)-2-(3-phenylpropylidene)propionyl-L-tryptophan-N-methylamide
-
-
(2E)-3-(N-hydroxycarbamoyl)-2-heptylidenepropionyl-L-tryptophan-N-methylamide
-
-
(2E)-3-(N-hydroxycarbamoyl)-2-isopropionyl-L-tryptophan-N-methylamide
-
-
(2E)-3-(N-hydroxycarbamoyl)-2-[(2E)-3-phenylprop-2-en-1-ylidene]propionyl-L-tryptophan-N-methylamide
-
-
(2E)-3-(N-hydroxycarbamoyl)-2-[(2E)-but-2-en-1-ylidene]propionyl-L-tryptophan-N-methylamide
-
-
1,10-phenanthroline
2-[(biphenyl-4-ylsulfonyl)(isobutyl)amino]-N-hydroxyacetamide
-
50% inhibition at 34 nM, comparison with inhibitory effect on matrix metalloproteinases MMP-3, MMp-7, MMP-2
3',4',5,6,7,8-hexamethoxyflavone
-
i.e. nobiletin
3',4'-di-O-methylbutin-7-O-[(6''->1''')-3''',11'''-dimethyl-7'''-methylenedodeca-3''',10'''-dienyl]-beta-D-glucopyranoside
-
0.0065-0.0259 mM suppresses MMP-9 activity in lipopolysaccharide-stimulated human monocytic cells without cytotoxicity
3',4'-di-O-methylquercetin-7-O-[(4''->13''')-2''',6''',10''',14'''-tetramethylhexadec-13'''-ol-14'''-enyl]-beta-D-glucopyranoside
-
0.0065-0.0259 mM suppresses MMP-9 activity in lipopolysaccharide-stimulated human monocytic cells without cytotoxicity
3',4'-dihydroxy-5,6,7,8-tetramethoxyflavone
-
-
3'-hydroxy-4',5,6,7,8-pentamethoxyflavone
-
-
4'-hydroxy-3',5,6,7,8-pentamethoxyflavone
-
-
4'-O-methylbutin-7-O-[(6->1''')-3''',11'''-dimethyl-7'''-hydroxymethylenedodecanyl]-beta-D-glucopyranoside
-
0.0065-0.0259 mM suppresses MMP-9 activity in lipopolysaccharide-stimulated human monocytic cells without cytotoxicity
4'-O-methylkaempferol-3-O-[(4''->13''')-2''',6''',10''',14'''-tetramethylhexadecan-13'''-olyl]-beta-D-glucopyranoside
-
0.0065-0.0259 mM suppresses MMP-9 activity in lipopolysaccharide-stimulated human monocytic cells without cytotoxicity
5-(1,5-dihydroxypentan-3-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
-
-
5-(4-hydroxybutan-2-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
-
-
5-(4-phenoxyphenyl)-5-(3-(1-nitrooxy-methyl)piperidin-1-yl)-pyrimidine-2,4,6(1H,3H,5H)-trione
-
-
5-(4-phenoxyphenyl)-5-(4-(1-nitrooxy-ethyl)piperidin-1-yl)-pyrimidine-2,4,6(1H,3H,5H)-trione
-
-
5-(4-phenoxyphenyl)-5-(4-(2-nitrooxy-ethyl)piperazin-1-yl)-pyrimidine-2,4,6(1H,3H,5H)-trione
-
-
5-(4-phenoxyphenyl)-5-(4-(2-nitrooxy-ethyl)piperidin-1-yl)-pyrimidine-2,4,6(1H,3H,5H)-trione
-
-
5-(4-phenoxyphenyl)-5-(bis-(2-nitrooxy-ethyl)-amino)pyrimidine-2,4,6(1H,3H,5H)-trione
-
-
5-(4-phenoxyphenyl)-5-(methyl-(2-nitrooxy-ethyl)-amino)-pyrimidine-2,4,6(1H,3H,5H)-trione
-
-
5-[3-(hydroxymethyl)piperidin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
-
-
5-[4-(2-hydroxyethyl)piperazin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
-
-
5-[4-(2-hydroxyethyl)piperidin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
-
-
5-[4-(hydroxymethyl)piperidin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
-
-
Ag-3340
-
i.e. N-hydroxy-2,2-dimethyl-4-[(4-phenoxyphenyl)sulfonyl]thiomorpholine-3-carboxamide, 50% inhibition at 0.26 nM, comparison with inhibitory effect on matrix metalloproteinases MMP-3, MMp-7, MMP-2
alpha-linolenic acid
-
antibody REGA-3G12
highly selective, potent MMP-9 inhibition, the antibody recognizes the N-terminal part, not the C-terminal hemopexin and O-glycosylated domains, epitope mapping, overview
-
carboxy-derivatized glucosamine
-
62% inhibition of MMP-9 at 0.5 mg/ml
-
CGS27023A
-
50% inhibition at 8 nM, comparison with inhibitory effect on matrix metalloproteinases MMP-3, MMp-7, MMP-2
chitooligosaccharides
-
different molecular weight, inhibit both MMP-9 expression and activity, especially 1- to 3-kDa chitooligosaccharides, chitooligosaccharides-I in HT-1080 cells
D-penicillamine
-
10 mg/l, 43% inhibition
docosahexaenoic acid
-
gamma-linolenic acid
-
hemopexin domain of MMP-9
the hemopexin domain of MMP-9 inhibits the degradation of gelatin. It also abolishes the degradation of gelatin by MMP-2. Blades 1 and 4 of the PEX9 domain are responsible for the gelatin degradation inhibitory activity of PEX9. The hemopexin domain of MMP-9 does not prevent the degradation of other MMP-9 substrates, such as a fluorogenic peptide, alphaB crystalline, or nonmuscular actin
-
ilomastat
Immunoglobulins purified from antisera raised against gelatinase
-
-
-
isovitexin
interacts with enzyme residues Glu241, Ala242, Pro255, Pro254, Thr251, Leu222, Tyr248, Arg241, Met247, His226, and Glu227, binding structure analysis, and modeling, overview
linoleic acid
-
MMP-9 inhibitor I
-
N-hydroxy-2-(isobutyl[(4-methoxyphenyl)sulfonyl]amino)acetamide
-
50% inhibition at 2.9 nM, comparison with inhibitory effect on matrix metalloproteinases MMP-3, MMp-7, MMP-2
N-isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid
NNGH
norcantharidin
-
i.e. exo-7-oxabicylo-[2.2.1] heptane-2,3-dicarboxylic anhydride, norcantharidin inhibits gelatinase activity of MM-9 in a concentration- and time-dependent manner
o-phenanthroline
-
-
oleic acid
-
polyhistidine
-
0.001 mM, 68% inhibition
proanthocyanidins
-
from the american cranberry, Vaccinium macrocarpon, decrease cellular viability of DU-145 cells via inhibition of MMP-9. The proanthocyanidins PACs increase the expression of TIMP-2, a known inhibitor of MMP activity, and decrease the expression of EMMPRIN, an inducer of MMP expression. Cranberry proanthocyanidins decrease MMP activity through the induction and/or inhibition of specific temporal MMP regulators, and by affecting either the phosphorylation status and/or expression of MAP kinase, PI-3 kinase, NF-kappaB and AP-1 pathway proteins
-
procyanidin oligomers
-
from Japanese quince, Chaenomeles japonica, fruit inhibit activity of MMP-9
-
REGA-3G12 scFv with (His6)2
-
monoclonal antibody REGA-3G12 single-chain variable fragment, 0.005 mM, 66% inhibition
-
reversion-inducing cysteine-rich protein with Kazal motifs
-
-
TIMP-1
-
TIMP-1/2
-
-
-
TIMP-2
-
TIMP-4
-
-
-
TIMP1
-
interaction analysis and structure modeling, overview
-
TIMP2
-
interaction analysis and structure modeling, overview
-
Tissue inhibitor
-
tissue inhibitor of matrix metalloproteinase 1
-
strong inhibitor of MMP-9
-
tissue inhibitor of matrix metalloproteinase-1
-
TIMP-1
-
tissue inhibitor of metalloproteinase TIMP-1
-
-
tissue inhibitor of metalloproteinase TIMP-2
-
-
Tissue inhibitor of metalloproteinase-1
-
Tissue inhibitor of metalloproteinase-2
-
-
tissue inhibitor of metalloproteinases 1
-
vitexin
interacts with enzyme residues Gly186, Pro246, His236, Met247, Tyr248, Val223, and Leu188, binding structure analysis, and modeling, overview
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,3,7,8-tetrachlorodibenzo-p-dioxin
-
both MMP-9 mRNA expression and enzymatic activity are gradually increased with the concentration increase of 2,3,7,8-tetrachlorodibenzo-p-dioxin in media and these changes can be reversed by resveratrol treatment in a dose-dependent manner, c-Jun mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced MMP-9 expression and activity
4-amino phenylmercuric acetate
-
pro-MMP-9 is activated with 1 mM 4-amino phenylmercuric acetate in assay buffer at 37°C for 1.5 h
4-aminophenylmercuric acetate
APMA
-
-
interleukin-1
-
-
-
interleukin-1beta
-
-
-
matrix metalloproteinase 3
-
converts inactive pro-MMP-9 to active MMP-9
-
phorbol 12-myristate 13-acetate
tumor necrosis factor-alpha
-
-
-
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0015
65000 MW form of vitronectin
-
-
-
0.00422 - 0.00496
N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl-7-methoxycoumarin-4-yl acetyl
0.000013 - 0.000025
stromelysin1
-
0.0013
vitronectin
-
75000 MW form
-
additional information
additional information
-
detailed binding kinetics
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.04 - 8.67
(7-methoxycoumaryl-4yl)acetylPLGLA2pr(2,4-dinitrophenol)-AR-NH2
0.00041 - 0.0019
stromelysin 1
-
0.0005
vitronectin of MW 65000
-
-
-
0.000333
vitronectin of MW 75000
-
-
-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00000713 - 0.00000817
TIMP-1
-
0.0000259 - 0.0000361
TIMP-2
-
additional information
additional information
-
detailed binding kinetics
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000045
(2E)-3-(N-hydroxycarbamoyl)-2-(3-phenylpropylidene)propionyl-L-tryptophan-N-methylamide
Homo sapiens
-
-
0.01
(2E)-3-(N-hydroxycarbamoyl)-2-heptylidenepropionyl-L-tryptophan-N-methylamide
Homo sapiens
-
above
0.000017
(2E)-3-(N-hydroxycarbamoyl)-2-isopropionyl-L-tryptophan-N-methylamide
Homo sapiens
-
-
0.000038
(2E)-3-(N-hydroxycarbamoyl)-2-[(2E)-3-phenylprop-2-en-1-ylidene]propionyl-L-tryptophan-N-methylamide
Homo sapiens
-
-
0.000974
(2E)-3-(N-hydroxycarbamoyl)-2-[(2E)-but-2-en-1-ylidene]propionyl-L-tryptophan-N-methylamide
Homo sapiens
-
-
0.017 - 0.0209
3',4',5,6,7,8-hexamethoxyflavone
0.0108 - 0.0123
3',4'-dihydroxy-5,6,7,8-tetramethoxyflavone
0.0164 - 0.0169
3'-hydroxy-4',5,6,7,8-pentamethoxyflavone
0.0037 - 0.0055
4'-hydroxy-3',5,6,7,8-pentamethoxyflavone
0.000026
5-(1,5-dihydroxypentan-3-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
Homo sapiens
-
pH 7.5, 37°C
0.000145
5-(4-hydroxybutan-2-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
Homo sapiens
-
pH 7.5, 37°C
0.000104
5-(4-phenoxyphenyl)-5-(3-(1-nitrooxy-methyl)piperidin-1-yl)-pyrimidine-2,4,6(1H,3H,5H)-trione
Homo sapiens
-
pH 7.5, 37°C
0.000152
5-(4-phenoxyphenyl)-5-(4-(1-nitrooxy-ethyl)piperidin-1-yl)-pyrimidine-2,4,6(1H,3H,5H)-trione
Homo sapiens
-
pH 7.5, 37°C
0.000092
5-(4-phenoxyphenyl)-5-(4-(2-nitrooxy-ethyl)piperazin-1-yl)-pyrimidine-2,4,6(1H,3H,5H)-trione
Homo sapiens
-
pH 7.5, 37°C
0.000202
5-(4-phenoxyphenyl)-5-(4-(2-nitrooxy-ethyl)piperidin-1-yl)-pyrimidine-2,4,6(1H,3H,5H)-trione
Homo sapiens
-
pH 7.5, 37°C
0.000091
5-(4-phenoxyphenyl)-5-(bis-(2-nitrooxy-ethyl)-amino)pyrimidine-2,4,6(1H,3H,5H)-trione
Homo sapiens
-
pH 7.5, 37°C
0.000048
5-(4-phenoxyphenyl)-5-(methyl-(2-nitrooxy-ethyl)-amino)-pyrimidine-2,4,6(1H,3H,5H)-trione
Homo sapiens
-
pH 7.5, 37°C
0.0000062
5-[3-(hydroxymethyl)piperidin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
Homo sapiens
-
pH 7.5, 37°C
0.0000081
5-[4-(2-hydroxyethyl)piperazin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
Homo sapiens
-
pH 7.5, 37°C
0.000012
5-[4-(2-hydroxyethyl)piperidin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
Homo sapiens
-
pH 7.5, 37°C
0.000097
5-[4-(hydroxymethyl)piperidin-1-yl]-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione
Homo sapiens
-
pH 7.5, 37°C
0.0000002 - 0.0000005
ilomastat
additional information
additional information
Homo sapiens
-
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.8
-
assay at
7.6
assay at
7.8
gelatinolytic activity
8.3
-
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
20 - 22
assay at
25 - 37
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
increased enzyme expression, the positive ratio of MMP-9 tends to increase from Grade II to Grade IV glioma and strong positive MMP-9 staining is more frequently detected in high-grade glioma, association between matrix metalloproteinase-9 expression and survival of patients
Manually annotated by BRENDA team
-
MMP-9 secretion
Manually annotated by BRENDA team
-
from femoral condyles in the knee
Manually annotated by BRENDA team
localized mainly in the cytoplasm of neoplastic astrocytes
Manually annotated by BRENDA team
-
expression and activity of MMP-9 during premature rupture of chorioamniotic membranes, secretion of proMMP-9 from the amniochorion after application of lipopolysacchride to either sides of the membrane is increased, overview
Manually annotated by BRENDA team
-
demineralized dentin matrix, extraction is best at acidic conditions of pH 2-3 compared to pH 7.4-EDTA-containing extracts
Manually annotated by BRENDA team
-
colon adenocarcinoma cell line
Manually annotated by BRENDA team
-
MMP-9 is expressed at very low levels in endometrioid adenocarcinoma cells
Manually annotated by BRENDA team
-
increased MMP-9 levels
Manually annotated by BRENDA team
-
airway
Manually annotated by BRENDA team
-
tumor periphery
Manually annotated by BRENDA team
-
neutrophil, commercial preparation
Manually annotated by BRENDA team
-
colon adenocarcinoma cell line
Manually annotated by BRENDA team
-
leukemia cell line, secretion of MMP-9
Manually annotated by BRENDA team
-
expression analysis of MMP 9 in benign, premalignant and malignant laryngeal lesions, e.g. carcinoma and dysplasia, the enzyme is upregulated in malignant tissue, immunohistochemic analysis, overview
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
the level of MMP-9 activity in lens epithelial cells is highest in eyes with cortical cataract
Manually annotated by BRENDA team
-
from surgical lobectomy for lung cancer
Manually annotated by BRENDA team
-
polymorphonuclear lymphocytes
Manually annotated by BRENDA team
-
treatment of blood-derived mast cells with TNF-alpha significantly increases expression of enzyme mRNA and upregulates enzyme activity. TNF-alpha also increases the invasiveness of mast cells across Matrigel-coated membranes. INF-gamma is inhibitory to enzyme mRNA and protein expression
Manually annotated by BRENDA team
-
cell expression system
Manually annotated by BRENDA team
-
atrophic acnd nonatrophic oral lichen planus
Manually annotated by BRENDA team
-
periapical ligament
Manually annotated by BRENDA team
-
no association between plasma MMP-9 activity and the concentrations of lead in whole blood or plasma, overview
Manually annotated by BRENDA team
-
primary bronchial epithelial cell
Manually annotated by BRENDA team
-
MMP-9 is expressed at very low levels in serous cystoadenocarcinoma cells
Manually annotated by BRENDA team
Mycobacterium tuberculosis stimulates matrix metalloproteinases secretion in the host. Analysis of the patterns of matrix metalloproteinase 9 (MMP-9) and 2 (MMP-2) isoforms in sputum samples, overview. Variations in MMP-9 isoforms are observed, which coincide with the progression of tuberculosis infection
Manually annotated by BRENDA team
-
stromal cells are the major source of MMP-9
Manually annotated by BRENDA team
-
colon adenocarcinoma cell line
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
-
-
Manually annotated by BRENDA team
additional information
-
secretion of proMMP-9 from the amniochorion after application of lipopolysacchride to either sidesof the membrane is increased, overview
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MMP9_HUMAN
707
0
78458
Swiss-Prot
Secretory Pathway (Reliability: 1)
Q9Y354_HUMAN
79
0
8943
TrEMBL
Secretory Pathway (Reliability: 1)
B7Z747_HUMAN
594
0
66180
TrEMBL
Secretory Pathway (Reliability: 1)
B7Z8A9_HUMAN
370
0
40863
TrEMBL
other Location (Reliability: 4)
B7Z507_HUMAN
648
0
71554
TrEMBL
other Location (Reliability: 5)
B7Z7V0_HUMAN
276
0
31145
TrEMBL
other Location (Reliability: 2)
MMP13_HUMAN
471
0
53820
Swiss-Prot
-
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
130000
200000
-
the molecular weight of proMMP-9 is about 200000 Da, SDS-PAGE
20947
-
x * 70795, calculated, enzyme mutant E402A, x * 20947, calculated, isolated enzyme collagen-binding domain
210000
dimeric form, SDS-PAGE
220000
-
native PAGE
225000
228300
enzyme multimer/trimer, PAGE, structure analysis by AFM
65000
65000 - 82000
major circulating MMP-9 enzyme forms: 92 kDa proMMP-9, and active 82 kDa and 65 kDa enzyme forms
67000
-
active form of MMP-9, SDS-PAGE
70795
-
x * 70795, calculated, enzyme mutant E402A, x * 20947, calculated, isolated enzyme collagen-binding domain
72000
-
active form of MMP-9, SDS-PAGE
78000
-
active form of MMP-9, SDS-PAGE
82000
84000
86000
88000
-
activated enzyme
89300
x * 89300, about, SDS-PAGE, the natural zymogen proMMP-9 occurs as monomers, homomultimers and heterocomplexes. MMP-9 homomultimers are reduction-sensitive trimers, three-dimensional structure molecular modeling, overview. Homomultimerization of the enzyme involves cysteine bridge formation. The zymogen proMMP-9 monomer includes the propeptide, the fibronectin-like domain, the Zn2+ -binding domain, the catalytic domain, the flexible OG domain, and the haemopexin-like domain
94000
-
-
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
homodimer
monomer
additional information
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glycoprotein
proteolytic modification
additional information
-
activation of pro-MMP-2 by 4-aminophenylmercuric acetate
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E402A
E412D
-
site-directed mutagenesis
P574R
-
the mutant is associated with a non-significant decreased risk of coronary artery disease when compared with the wild type genotype
R279Q
R668Q
-
the mutant is associated with a non-significant decreased risk of coronary artery disease when compared with the wild type genotype
additional information
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, stored in 50% glycerol, complete retention of activity forat least 1 month
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
catalytic domain of mutated enzyme
-
gelatin Sepharose 4B bead chromatography
-
gelatin-Sepharose column chromatography
-
native enzyme from serum samples by concanavalin-A and gelatin afffinity chromatography, and ultrafiltration
native MMP-9 from dentin inculding serial dilutions, method development
-
purification, refolding and in vitro recovery of active full length recombinant human gelatinase MMP-9
recombinant enzyme
-
recombinant full-length pro-MMP-9 from Spodoptera frugiperda Sf9 cells
-
recombinant full-length proMMP-9 and mutant enzymes from Spodoptera frugiperda Sf9 insect cells
-
recombinant MMP-9 from Spodoptera frugiperda Sf9 cells
-
recombinant wild-type and mutant zymogen from Sf9 insect cells by gelatin affinity chromatography
SC40-transformed cells
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cDNA of the mutated enzyme used to transfect HEK 293 cells
-
expressed in baculovirus-infected Spodoptera frugiperda IPLB-Sf21 AE cells
-
expressed in CT-26 cells
-
expressed in immortalized keratinocytes, transduced by lentivrus
-
expression in H9C2 cell
-
expression in the form of inclusion bodies in Escherichia coli BL21, using pET21a vector
expression of full-length pro-MMP-9 in Spodoptera frugiperda Sf9 cells
-
expression of full-length proMMP-9 and of mutant enzymes in Spodoptera frugiperda Sf9 insect cells using the baculovirus infection system
-
expression of MMP-9 in Spodoptera frugiperda Sf9 cells
-
expresssion of wild-type MMP-9 and truncated versions in insect cells
gene MMP-9, quantitative real time PCR expression analysis in glioblastoma
gene MMP9, quantitative real-time PCR enzyme expression analysis
gene MMP9, quantitative RT-PCR enzyme expression analysis
recombinant expression of the wild-type and mutant zymogen in Spodoptera frugiperda Sf9 cells
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
0.025 mM panduratin A markedly down-regulates MMP-9 expression
-
0.025-0.1 mM 6-hydroxydopamine and 0.05-0.5 mM 1-methyl-4-phenylpyridinium ion increase MMP-9 gene expression in a dose-dependent manner by inducing nuclear factor-kappaB and AP-1 binding to the MMP-9 promoter, N-acetylcysteine suppresses both 6-hydroxydopamine- and 1-methyl-4-phenylpyridinium ion-induced MMP-9 promoter activities, LY294002, suppresses 6-hydroxydopamine- and 1-methyl-4-phenylpyridinium ion-induced MMP-9 promoter activities, whereas SB203580 inhibits 6-hydroxydopamine-, but not 1-methyl-4-phenylpyridinium ion-induced promoter activity, neither PD98059 nor SP600125 influence 6-hydroxydopamine or 1-methyl-4-phenylpyridinium ion-induced MMP-9 promoter activity
-
10 ng/ml transforming growth factor-beta1 and 10 ng/ml transforming growth factor-beta2 enhance the secretion of matrix metalloproteinase-9 in PC-3 cells 5.4fold and 4.3fold, respectively
-
10 nM 12-O-tetradecanoyl phorbol-13-acetate induces MMP-9 expression (9728.9% of the control) after 24 h by the suppression of the Raf/MEK/ERK pathway in MCF-7 human breast cancer cells, 12-O-tetradecanoyl phorbol-13-acetate-induced MMP-9 expression is significantly inhibited by UO126, but not by SP600125 and SB203580
-
10% (v/v) Porphyromonas gingivalis supernatant induces about 2.5fold increased MMP-9 expression in human oral epidermoid cells
-
12-O-tetradecanoyl phorbol-13-acetate-induced MMP-9 expression is decreased by 324.8% by 0.1 mM silibinin
-
20 mg doxycycline decreases MMP-9 levels after 1 month, 20 mg doxycycline decreases endometrial MMP-9 at 1 and 6 months compared to baseline
-
a significant increase in MMP-9 is observed in pulmonary tuberculosis patients as compared to healthy controls
-
A3 receptor stimulation induces an increase of MMP-9 protein levels in cellular extracts of U87MG cells by phosphorylation of extracellular signal-regulated protein kinases, c-Jun N-terminal kinase/stress-activated protein kinase, protein kinase B, and activator protein 1. A3 receptor activation stimulates also an increase of extracellular MMP-9 in the supernatants from U87MG glioblastoma cells
-
active treatment with uric acid (0.5 or 1.0 mg) is associated with reduced levels of active MMP-9 at the end of infusion
-
after 24 h incubation, 0.05 mg/ml aspirin inhibits MMP-9 mRNA expression by 50%. MMP-9 mRNA expression and release are inhibited by fenofibrate (0.1 mM) and 15d-prostaglandin J2 (0.005 mM)
-
aqueous extract isolated from Prunella vulgaris suppresses 12-phorbol 13-myristate acetate-enhanced expression of MMP-9 protein, mRNA and transcription activity levels through suppression of nuclear factor-kappaB activation
-
berberine inhibits the expression of MMP-9 at both the mRNA and protein levels in a dose-dependent manner (0.005-0.05 mM) by suppressing the activation of p38 pathway in phorbol 12-myristate 13-acetate-induced macrophages
-
C-reactive protein increases the expression and activity of MMP-9 in a dose-dependent manner in human THP-1 cells
-
circulating MMP-9 concentrations are higher in patients with abdominal aortic aneurysm than those in subjects without abdominal aortic aneurysm
-
diet-induced long-term weight loss decreases MMP-9
-
Dz13 upregulates the matrix metalloproteinase-9 in cultured tumor cells
-
epidermal growth factor contributes to prostate cancer metastasis through stimulating MMP-9 secretion from prostate cancer cells
-
exposure of KB cells to Porphyromonas gingivalis supernatant (10% v/v) up-regulates the expression of MMP-9 protein and gene, the JNK inhibitor SP600125 (0.02 mM) significantly attenuates MMP-9 gene expression in KB cells in response to Porphyromonas gingivalis supernatant. JNK and AP-1 are the major signaling for Porphyromonas gingivalis supernatant-stimulated MMP-9 expression in KB cells
-
heregulin-beta1 stimulates MMP-9 secretion and activation via a transcriptional regulation in human breast cancer cells
-
higher plasma MMP-9 concentrations are found in periodontal disease patients compared with healthy controls
-
homocysteine increases mRNA expression of MMP-9
-
immune cell secretion of MMP-9 decreases by 58% after 3 months of omega-3 fatty acid supplementation when compared with baseline levels in patients with relapsing-remitting multiple sclerosis
-
in sections of ectopic tumors treated with Dz13, MMP-9 is downregulated
-
in the human vascular endothelium, simvastatin and atorvastatin (0.0001-0.01 mM) reduce MMP-9 expression and activity
-
induction of MMP-9 expression and activity is significantly inhibited by 0.001 mM of the specific cPLA2alpha inhibitor
-
interferon-gamma suppresses MMP-9 expression
-
interleukin 1beta, interleukin-6, and tumor necrosis factor -alpha stimulate MMP-9 expression
-
islet MMP-9 mRNA levels are decreased in type 2 diabetic subjects
leucine-zipper and sterile-alpha motif kinase reduces MMP-9 activity by increasing TIMP-1/2 expression in H9c2 cardiomyoblast cells
-
levels of MMP-9 in choriodecidua and amnion increases 4 and 8fold, respectively, after simultaneous infection with Escherichia coli added to either the amniotic or the choriodecidual face or to both
-
levonorgestrel subcutaneous implant increases serum MMP-9 levels after 1 month
-
matrix metalloproteinase-9 is significantly increased after 8 weeks of very low energy diet-induced weight loss
-
MMP-9 is moderately induced by Fusobacterium nucleatum and considerably induced by phorbol 12-myristate-13-acetate in gingival epithelial cells, MMP-9 mRNA up-regulation occurs at 3 h, whereas MMP-9 secretion and activity in cell-free supernatants occurs at 12 h
-
MMP-9 is significantly increased in the infarcted tissue compared to the contralateral hemisphere after ischemic stroke
-
MMP-9 mRNA expression and release are induced by 0.002 mM prostaglandin E2
-
MMP-9 protein and mRNA levels are decreased up to 43% after treatment with 0.025 mM panduratin A
-
Mycobacterium tuberculosis stimulates matrix metalloproteinases secretion in the host
N-2-(4-bromophenyl) ethyl caffeamide inhibits MMP-9 production through the nuclear-targeted down-regulation of nuclear factor-kappaB signaling in human monocytic cells
-
no significant difference is observed in the levels of MMP-9 in culture filtrate antigen and live Mycobacterium tuberculosis-stimulated as well as unstimulated cultures of both healthy controls and pulmonary tuberculosis patients
-
non-surgical periodontal therapy decreases blood plasma MMP-9 concentration by 39%
-
norcantharidin downregulates MMP-9 mRNA and protein expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells, norcantharidin at 0.1 mM completely abolishes the expression of MMP-9 mRNA at 48 h
-
nuclear factor-kappaB is a key transcription factor for the production of MMP-9, tumor necrosis factor-alpha induces expression of MMP-9 at both mRNA and protein levels, tumor necrosis factor-alpha-induced expression of MMP-9 is completely blocked by N-2-(4-bromophenyl) ethyl caffeamide in a concentration-dependent (0.001-0.02 mM) manner
-
obese individuals show increased activity of MMP-9/LCN2 complex, while a positive correlation between MMP-9 activity and body mass index is observed
-
overexpression of reversion-inducing cysteine-rich protein with Kazal motifs in HT-1080 cells decreases MMP-9 mRNA levels, reversion-inducing cysteine-rich protein with Kazal motifs-mediated suppression of MMP-9 promoter activity requires 12-O-tetradecanoylphorbol-13-acetate-responsive element and KB sites
-
penta-O-galloyl-beta-D-glucose inhibits epidermal growth factor-induced MMP-9 expression in a dose- and time-dependent manner by reducing the MMP-9 transcriptional activity
-
propranolol significantly reduces MMP-9 secretion upon treatment with phorbol 12-myristate 13-acetate which is correlated with a decrease in MMP-9 gene expression
-
pterostilbene (i.e. trans-3,5-dimethoxy-4'-hydroxystilbene) down-regulates matrix metalloproteinase-9 activity and inhibits protein and mRNA expression of MMP-9 driven by heregulin-beta1
-
serum MMP-9 concentrations are significantly higher in patients with non-herpetic acute limbic encephalitis in acute and convalescent stages than in control patients
-
silibinin suppresses 12-O-tetradecanoyl phorbol-13-acetate-induced MMP-9 expression through inhibition of COX-2 (106% decrease of expression at 0.2 mM silibinin), 12-O-tetradecanoyl phorbol-13-acetate-induced MMP-9 expression is inhibited by celecoxib in a dose-dependent fashion, 12-O-tetradecanoyl phorbol-13-acetate-induced MMP-9 expression is decreased by UO126
-
Skp2 overexpression increases the expression of MMP-9, Sp1 is involved in the induction of MMP-9 by Skp2
-
tear MMP-9 activity is significantly higher in patients with dysfunctional tear syndrome, this activity is associated with increased mRNA expression of MMP-9
-
the antihemorrhagic effect of PJ34, a potent PARP inhibitor, is associated with a 57% decrease in MMP-9 overexpression, glucocorticoid increases TIMP-1 in the brain endothelial cell line cEND to reduce the levels of MMP-9
-
the early increase in MMP-9 blood plasma activity in patients with acute coronary syndrome is related to MMPs activation in the unstable atherosclerotic plaque
-
the ethanolic extract from Kaempferia pandurata significantly decreases MMP-9 expression at both protein and mRNA levels in a dose-dependent manner(0.002-0.01 mg/ml). Treatment of ethanolic Kaempferia pandurata extract at 0.002, 0.005 and 0.01 mg/ml shows decreases in MMP-9 mRNA levels up to 10%, 13%, and 45%, respectively. Kaempferia pandurata interfers Porphyromonas gingivalis supernatant-induced MMP-9 expression in the oral epidermoid cell line ATCC CCL-17
-
the expression of MMP-9 in neoplastic and inflammatory cells increases with more advance tumor stage, depth of tumor invasion and presence of lymph node as well as distant metastases
-
the expression of MMP-9 is elevated after cerebral ischemia, expression of MMP-9 increases after permanent middle cerebral artery occlusion and transient middle cerebral artery occlusion. interleukin-1beta, tissue necrosis factor-alpha, fibroblast growth facor, and epidermal growth factor can stimulate the secretion of MMP-9
-
the interleukin-1beta-induced MMP-9 gene expression is mediated through the activation of p42/p44 mitogen-activated protein kinase, p38 mitogen-activated protein kinase, and JNK1/2 in A-549 cells. The interleukin-1beta-induced MMP-9 gene expression is also mediated through the translocation of NF-kappaB (p65) into the nucleus and the degradation of IkappaBalpha
-
the level of MMP-9 expression was significantly increased by 4945% and 4412% of the control level following treatment with 20 nM 12-O-tetradecanoyl phorbol-13-acetate in breast cancer cells
-
the serum MMP-9 level is significantly higher in moyamoya disease than in healthy controls
-
there is a highly significant relationship between the expression of MMP-9 and macrophage count in eosinophilic granulomas
-
there is no MMP-9 mRNA elevation in mononuclear cells
-
there is significant reduction in MMP-9 expression on day 7 in all cases, it decreases considerably on day 14 and is almost negligible on day 21 reflecting corneal healing with succinylated collagen bandage lenses
-
thrombin stimulation induces MMP-9 secretion of monocytes dose- and time-dependently through activation of extracellular signaling-regulated protein kinase 1/2 and p38. Thrombin up-regulates mRNA and protein levels of MMP-9. NFkappaB activation is necessary for thrombin-induced MMP-9 upregulation in human monocytes. 1,2-bis (aminophenoxy) ethane-N,N,N',N'-tetraacetoxymethyl ester, a Ca2+ chelator, abolishes the thrombin-induced MMP-9 secretion
-
treatment with 0.05 mM glycitein downregulates MMP-9 gene expression and inhibits the phorbol myristate acetate-induced MMP-9 secretion in U87MGcells
-
TX-1877 significantly inhibits expression of MMP-9
-
vitamin D3 significantly reduces the MMP-9 level in antigen stimulated and unstimulated cultures of pulmonary tuberculosis as compared to healthy controls
-
RENATURED/Commentary
ORGANISM
UNIPROT
LITERATURE
the effect of pH (in the range of 4.5-9.5) is investigated on the refolding of recombinant human MMP-9 by urea gradient method. Maximum recovery is obtained at pH 7.8 (with NaCl and Tris-HCl buffer)
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
diagnostics
drug development
medicine
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Netzel-Arnett, S.; Sang, Q.X.; Moore, W.G.I.; Navre, M.; Birkedal-Hansen, H.; van Wart, H.E.
Comparative sequence specificities of human 72- and 92-kDa gelatinases (type IV collagenases) and PUMP (matrilysin)
Biochemistry
32
6427-6432
1993
Homo sapiens
Manually annotated by BRENDA team
Nguyen, Q.; Murphy, G.; Hughes, C.E.; Mort, J.S.; Roughley, P.J.
Matrix metalloproteinases cleave at two distinct sites on human cartilage link protein
Biochem. J.
295
595-598
1993
Homo sapiens
Manually annotated by BRENDA team
Ochieng, J.; Fridman, R.; Nangia-Makker, P.; Kleiner, D.E.; Liotta, L.A.; Stetler-Stevenson, W.G.; Raz, A.
Galectin-3 is a novel substrate for human matrix metalloproteinases-2 and -9
Biochemistry
33
14109-14114
1994
Homo sapiens
Manually annotated by BRENDA team
Allan, J.A.; Docherty, A.J.P.; Barker, P.J.; Huskisson, N.S.; Reynolds, J.J.; Murphy, G.
Binding of gelatinases A and B to type-I collagen and other matrix components
Biochem. J.
309
299-306
1995
Homo sapiens
Manually annotated by BRENDA team
Imai, K.; Shikata, H.; Okada, Y.
Degradation of vitronectin by matrix metalloproteinases-1, -2, -3, -7 and -9
FEBS Lett.
369
249-251
1995
Homo sapiens
Manually annotated by BRENDA team
Wilhelm, S.M.; Collier, I.E.; Marmer, B.L.; Eisen, A.Z.; Grant, G.A.; Goldberg, G.I.
SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages [published erratum appears in J Biol Chem 1990 Dec 25;265(36):22570]
J. Biol. Chem.
264
17213-17221
1989
Homo sapiens
Manually annotated by BRENDA team
O'Connelll, J.P.; Willenbrock, F.; Docherty, A.J.P.; Eaton, D.; Murphy, G.
Analysis of the role of the COOH-terminal domain in the activation, proteolytic activity, and tissue inhibitor of metalloproteinase interactions of gelatinase B
J. Biol. Chem.
269
14967-14973
1994
Homo sapiens
Manually annotated by BRENDA team
McGeehan, G.M.; Bickett, D.M.; Green, M.; Kassel, D.; Wiseman, J.S.; Berman, J.
Characterization of the peptide substrate specificities of interstitial collagenase and 92-kDa gelatinase. Implications for substrate optimization
J. Biol. Chem.
269
32814-32820
1994
Homo sapiens
Manually annotated by BRENDA team
Sires, U.I.; Dublet, B.; Aubert-Foucher, E.; van der Rest, M.; Welgus, H.G.
Degradation of the COL1 domain of type XIV collagen by 92-kDa gelatinase
J. Biol. Chem.
270
1062-1067
1995
Homo sapiens
Manually annotated by BRENDA team
Morel, F.; Berthier, S.; Guillot, M.; Zaoui, P.; Massoubre, C.; Didier, F.; Vignais, P.V.
Human neutrophil gelatinase is a collagenase type IV
Biochem. Biophys. Res. Commun.
191
269-274
1993
Homo sapiens
Manually annotated by BRENDA team
Pourmotabbed, T.; Aelion, J.A.; Tyrrell, D.; Hasty, K.A.; Bu, C.H.; Mainardi, C.L.
Role of the conserved histidine and aspartic acid residues in activity and stabilization of human gelatinase B: an example of matrix metalloproteinases
J. Protein Chem.
14
527-535
1995
Homo sapiens
Manually annotated by BRENDA team
Ochieng, J.; Warfield, P.; Green, B.
Interactions of gelatinases with soluble and immobilized fetuin and asialofetuin
Arch. Biochem. Biophys.
322
250-255
1995
Homo sapiens
Manually annotated by BRENDA team
Makowski, G.S.; Ramsby, M.L.
Binding of matrix metalloproteinase 9 to fibrin is mediated by amorphous calcium-phosphate
Inflammation
22
599-617
1998
Homo sapiens
Manually annotated by BRENDA team
Olson, M.W.; Bernardo, M.M.; Pietila, M.; Gervasi, D.C.; Toth, M.; Kotra, L.P.; Massova, I.; Mobashery, S.; Fridman, R.
Characterization of the monomeric and dimeric forms of latent and active matrix metalloproteinase-9. Differential rates for activation by stromelysin 1
J. Biol. Chem.
275
2661-2668
2000
Homo sapiens (P45452)
Manually annotated by BRENDA team
Kleifeld, O.; Van den Steen, P.E.; Frenkel, A.; Cheng, F.; Jiang, H.L.; Opdenakker, G.; Sagi, I.
Structural characterization of the catalytic active site in the latent and active natural gelatinase B from human neutrophils
J. Biol. Chem.
275
34335-34343
2000
Homo sapiens
Manually annotated by BRENDA team
Chen, E.I.; Li, W.; Godzik, A.; Howard, E.W.; Smith, J.W.
A residue in the S2 subsite controls substrate selectivity of matrix metalloproteinase-2 and matrix metalloproteinase-9
J. Biol. Chem.
278
17158-17163
2003
Homo sapiens
Manually annotated by BRENDA team
George, H.J.; Marchand, P.; Murphy, K.; Wiswall, B.H.; Dowling, R.; giannaras, J.; Hollis, G.F.; Trzaskos, J.M.; Copeland, R.A.
Recombinant human 92-kDa type IV collagenase/gelatinase from baculovirus-infected insect cells: expression, purification, and characterization
Protein Expr. Purif.
10
154-161
1997
Homo sapiens
Manually annotated by BRENDA team
Xu, X.; Chen, Z.; Wang, Y.; Yamada, Y.; Steffensen, B.
Functional basis for the overlap in ligand interactions and substrate specificities of matrix metalloproteinases-9 and -2
Biochem. J.
392
127-134
2005
Homo sapiens
Manually annotated by BRENDA team
Hu, J.; Van den Steen, P.E.; Houde, M.; Ilenchuk, T.T.; Opdenakker, G.
Inhibitors of gelatinase B/matrix metalloproteinase-9 activity. Comparison of a peptidomimetic and polyhistidine with single-chain derivatives of a neutralizing monoclonal antibody
Biochem. Pharmacol.
67
1001-1009
2004
Homo sapiens
Manually annotated by BRENDA team
Van den Steen, P.E.; Proost, P.; Brand, D.D.; Kang, A.H.; Van Damme, J.; Opdenakker, G.
Generation of glycosylated remnant epitopes from human collagen type II by gelatinase B
Biochemistry
43
10809-10816
2004
Homo sapiens
Manually annotated by BRENDA team
Rossello, A.; Nuti, E.; Orlandini, E.; Carelli, P.; Rapposelli, S.; Macchia, M.; Minutolo, F.; Carbonaro, L.; Albini, A.; Benelli, R.; Cercignani, G.; Murphy, G.; Balsamo, A.
New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2)
Bioorg. Med. Chem.
12
2441-2450
2004
Homo sapiens
Manually annotated by BRENDA team
Meyer, E.; Vollmer, J.Y.; Bovey, R.; Stamenkovic, I.
Matrix metalloproteinases 9 and 10 inhibit protein kinase C-potentiated, p53-mediated apoptosis
Cancer Res.
65
4261-4272
2005
Homo sapiens
Manually annotated by BRENDA team
Chintala, S.K.; Wang, N.; Diskin, S.; Mattox, C.; Kagemann, L.; Fini, M.E.; Schuman, J.S.
Matrix metalloproteinase gelatinase B (MMP-9) is associated with leaking glaucoma filtering blebs
Exp. Eye Res.
81
429-436
2005
Homo sapiens
Manually annotated by BRENDA team
Descamps, F.J.; Martens, E.; Kangave, D.; Struyf, S.; Geboes, K.; Van Damme, J.; Opdenakker, G.; Abu El-Asrar, A.M.
The activated form of gelatinase B/matrix metalloproteinase-9 is associated with diabetic vitreous hemorrhage
Exp. Eye Res.
83
401-407
2006
Homo sapiens
Manually annotated by BRENDA team
Abu El-Asrar, A.M.; Struyf, S.; Van den Broeck, C.; Van Damme, J.; Opdenakker, G.; Geboes, K.; Kestelyn, P.
Expression of chemokines and gelatinase B in sympathetic ophthalmia
Eye
21
649-657
2006
Homo sapiens
Manually annotated by BRENDA team
Descamps, F.J.; Martens, E.; Proost, P.; Starckx, S.; Van den Steen, P.E.; Van Damme, J.; Opdenakker, G.
Gelatinase B/matrix metalloproteinase-9 provokes cataract by cleaving lens betaB1 crystallin
FASEB J.
19
29-35
2005
Homo sapiens
Manually annotated by BRENDA team
Di Carlo, A.; Terracciano, D.; Mariano, A.; Macchia, V.
Matrix metalloproteinase-2 and matrix metalloproteinase-9 type IV collagenases in serum of patients with pleural effusions
Int. J. Oncol.
26
1363-1368
2005
Homo sapiens
Manually annotated by BRENDA team
Di Girolamo, N.; Indoh, I.; Jackson, N.; Wakefield, D.; McNeil, H.P.; Yan, W.; Geczy, C.; Arm, J.P.; Tedla, N.
Human mast cell-derived gelatinase B (matrix metalloproteinase-9) is regulated by inflammatory cytokines: role in cell migration
J. Immunol.
177
2638-2650
2006
Homo sapiens
Manually annotated by BRENDA team
Shimanovich, I.; Mihai, S.; Oostingh, G.J.; Ilenchuk, T.T.; Broecker, E.B.; Opdenakker, G.; Zillikens, D.; Sitaru, C.
Granulocyte-derived elastase and gelatinase B are required for dermal-epidermal separation induced by autoantibodies from patients with epidermolysis bullosa acquisita and bullous pemphigoid
J. Pathol.
204
519-527
2004
Homo sapiens
Manually annotated by BRENDA team
Leveque, T.; Le Pavec, G.; Boutet, A.; Tardieu, M.; Dormont, D.; Gras, G.
Differential regulation of gelatinase A and B and TIMP-1 and -2 by TNFalpha and HIV virions in astrocytes
Microbes Infect.
6
157-163
2004
Homo sapiens
Manually annotated by BRENDA team
Lindberg, R.L.; Sorsa, T.; Tervahartiala, T.; Hoffmann, F.; Mellanen, L.; Kappos, L.; Schaad, U.B.; Leib, S.L.; Leppert, D.
Gelatinase B [matrix metalloproteinase (MMP)-9] and collagenases (MMP-8/-13) are upregulated in cerebrospinal fluid during aseptic and bacterial meningitis in children
Neuropathol. Appl. Neurobiol.
32
304-317
2006
Homo sapiens
Manually annotated by BRENDA team
Di Carlo, A.; Terracciano, D.; Mariano, A.; Macchia, V.
Urinary gelatinase activities (matrix metalloproteinases 2 and 9) in human bladder tumors
Oncol. Rep.
15
1321-1326
2006
Homo sapiens
Manually annotated by BRENDA team
Zhang, L.; Shi, J.; Feng, J.; Klocker, H.; Lee, C.; Zhang, J.
Type IV collagenase (matrix metalloproteinase-2 and -9) in prostate cancer
Prostate Cancer Prostatic. Dis.
7
327-332
2004
Homo sapiens
Manually annotated by BRENDA team
Adair, J.C.; Charlie, J.; Dencoff, J.E.; Kaye, J.A.; Quinn, J.F.; Camicioli, R.M.; Stetler-Stevenson, W.G.; Rosenberg, G.A.
Measurement of gelatinase B (MMP-9) in the cerebrospinal fluid of patients with vascular dementia and Alzheimer disease
Stroke
35
e159-e162
2004
Homo sapiens
Manually annotated by BRENDA team
Unsal, D.; Akyurek, N.; Uner, A.; Erpolat, O.P.; Han, U.; Akmansu, M.; Mentes, B.B.; Dursun, A.
Gelatinase B expression as a prognostic factor in patients with stage II/III rectal carcinoma treated by postoperative adjuvant therapy
Am. J. Clin. Oncol.
31
55-63
2008
Homo sapiens
Manually annotated by BRENDA team
Barbosa, F.; Gerlach, R.F.; Tanus-Santos, J.E.
Matrix metalloproteinase-9 activity in plasma correlates with plasma and whole blood lead concentrations
Basic Clin. Pharmacol. Toxicol.
98
559-564
2006
Homo sapiens
Manually annotated by BRENDA team
Geurts, N.; Martens, E.; Van Aelst, I.; Proost, P.; Opdenakker, G.; Van den Steen, P.E.
Beta-hematin interaction with the hemopexin domain of gelatinase B/MMP-9 provokes autocatalytic processing of the propeptide, thereby priming activation by MMP-3
Biochemistry
47
2689-2699
2008
Homo sapiens
Manually annotated by BRENDA team
Martens, E.; Leyssen, A.; Van Aelst, I.; Fiten, P.; Piccard, H.; Hu, J.; Descamps, F.J.; Van den Steen, P.E.; Proost, P.; Van Damme, J.; Liuzzi, G.M.; Riccio, P.; Polverini, E.; Opdenakker, G.
A monoclonal antibody inhibits gelatinase B/MMP-9 by selective binding to part of the catalytic domain and not to the fibronectin or zinc binding domains
Biochim. Biophys. Acta
1770
178-186
2007
Homo sapiens (P14780), Homo sapiens
Manually annotated by BRENDA team
Moroy, G.; Denhez, C.; El Mourabit, H.; Toribio, A.; Dassonville, A.; Decarme, M.; Renault, J.H.; Mirand, C.; Bellon, G.; Sapi, J.; Alix, A.J.; Hornebeck, W.; Bourguet, E.
Simultaneous presence of unsaturation and long alkyl chain at P1 of Ilomastat confers selectivity for gelatinase A (MMP-2) over gelatinase B (MMP-9) inhibition as shown by molecular modelling studies
Bioorg. Med. Chem.
15
4753-4766
2007
Homo sapiens
Manually annotated by BRENDA team
Mendis, E.; Kim, M.M.; Rajapakse, N.; Kim, S.K.
Carboxy derivatized glucosamine is a potent inhibitor of matrix metalloproteinase-9 in HT1080 cells
Bioorg. Med. Chem. Lett.
16
3105-3110
2006
Homo sapiens
Manually annotated by BRENDA team
Soeder, S.; Roach, H.I.; Oehler, S.; Bau, B.; Haag, J.; Aigner, T.
MMP-9/gelatinase B is a gene product of human adult articular chondrocytes and increased in osteoarthritic cartilage
Clin. Exp. Rheumatol.
24
302-304
2006
Homo sapiens
Manually annotated by BRENDA team
Lee, Y.M.; Lee, J.J.; Shen, M.Y.; Hsiao, G.; Sheu, J.R.
Inhibitory mechanisms of activated matrix metalloproteinase-9 on platelet activation
Eur. J. Pharmacol.
537
52-58
2006
Homo sapiens
Manually annotated by BRENDA team
Bigg, H.F.; Rowan, A.D.; Barker, M.D.; Cawston, T.E.
Activity of matrix metalloproteinase-9 against native collagen types I and III
FEBS J.
274
1246-1255
2007
Homo sapiens
Manually annotated by BRENDA team
Abdallah, M.A.; Kang, S.; Nakajima, S.T.; Gercel-Taylor, C.
Matrix metalloproteinase-9 activity in the plasma of patients after surgical resection of endometriomas
Fertil. Steril.
85
1847-1848
2006
Homo sapiens
Manually annotated by BRENDA team
Peschos, D.; Damala, C.; Stefanou, D.; Tsanou, E.; Assimakopoulos, D.; Vougiouklakis, T.; Charalabopoulos, K.; Agnantis, N.J.
Expression of matrix metalloproteinase-9 (gelatinase B) in benign, premalignant and malignant laryngeal lesions
Histol. Histopathol.
21
603-608
2006
Homo sapiens
Manually annotated by BRENDA team
Cho, Y.B.; Lee, W.Y.; Song, S.Y.; Shin, H.J.; Yun, S.H.; Chun, H.K.
Matrix metalloproteinase-9 activity is associated with poor prognosis in T3-T4 node-negative colorectal cancer
Hum. Pathol.
38
1603-1610
2007
Homo sapiens
Manually annotated by BRENDA team
Strek, M.; Gorlach, S.; Podsedek, A.; Sosnowska, D.; Koziolkiewicz, M.; Hrabec, Z.; Hrabec, E.
Procyanidin oligomers from Japanese quince (Chaenomeles japonica) fruit inhibit activity of MMP-2 and MMP-9 metalloproteinases
J. Agric. Food Chem.
55
6447-6452
2007
Homo sapiens
Manually annotated by BRENDA team
Vempati, P.; Karagiannis, E.D.; Popel, A.S.
A biochemical model of matrix metalloproteinase 9 activation and inhibition
J. Biol. Chem.
282
37585-37596
2007
Homo sapiens
Manually annotated by BRENDA team
Mazzoni, A.; Mannello, F.; Tay, F.R.; Tonti, G.A.; Papa, S.; Mazzotti, G.; Di Lenarda, R.; Pashley, D.H.; Breschi, L.
Zymographic analysis and characterization of MMP-2 and -9 forms in human sound dentin
J. Dent. Res.
86
436-440
2007
Homo sapiens
Manually annotated by BRENDA team
Ho, T.Y.; Yan, W.; Bagnell, C.A.
Relaxin-induced matrix metalloproteinase-9 expression is associated with activation of the NF-kappaB pathway in human THP-1 cells
J. Leukoc. Biol.
81
1303-1310
2007
Homo sapiens
Manually annotated by BRENDA team
Van Ta, Q.; Kim, M.M.; Kim, S.K.
Inhibitory effect of chitooligosaccharides on matrix metalloproteinase-9 in human fibrosarcoma cells (HT1080)
Mar. Biotechnol.
8
593-599
2007
Homo sapiens
Manually annotated by BRENDA team
Garcia-Lopez, G.; Vadillo-Ortega, F.; Merchant-Larios, H.; Maida-Claros, R.; Osorio, M.; Soriano-Becerril, D.; Flores-Herrera, H.; Beltran-Montoya, J.; Garfias-Becerra, Y.; Zaga-Clavellina, V.
Evidence of in vitro differential secretion of 72 and 92 kDa type IV collagenases after selective exposure to lipopolysaccharide in human fetal membranes
Mol. Hum. Reprod.
13
409-418
2007
Homo sapiens
Manually annotated by BRENDA team
Rosenblum, G.; Van den Steen, P.E.; Cohen, S.R.; Grossmann, J.G.; Frenkel, J.; Sertchook, R.; Slack, N.; Strange, R.W.; Opdenakker, G.; Sagi, I.
Insights into the structure and domain flexibility of full-length pro-matrix metalloproteinase-9/gelatinase B
Structure
15
1227-1236
2007
Homo sapiens
Manually annotated by BRENDA team
Dragutinovic, V.V.; Radovanovic, N.S.; Izrael-Zivkovic, L.T.; Vrvic, M.M.
Detection of gelatinase B activity in serum of gastric cancer patients
World J. Gastroenterol.
12
105-109
2006
Homo sapiens
Manually annotated by BRENDA team
Bhattacharyya, S.; Tobacman, J.K.
Arylsulfatase B regulates colonic epithelial cell migration by effects on MMP9 expression and RhoA activation
Clin. Exp. Metastasis
26
535-545
2009
Homo sapiens
Manually annotated by BRENDA team
Lin, C.K.; Chao, T.K.; Yu, C.P.; Yu, M.H.; Jin, J.S.
The expression of six biomarkers in the four most common ovarian cancers: correlation with clinicopathological parameters
APMIS
117
162-175
2009
Homo sapiens
Manually annotated by BRENDA team
Hlawaty, H.; Jacob, M.P.; Louedec, L.; Letourneur, D.; Brink, C.; Michel, J.B.; Feldman, L.; Baeck, M.
Leukotriene receptor antagonism and the prevention of extracellular matrix degradation during atherosclerosis and in-stent stenosis
Arterioscler. Thromb. Vasc. Biol.
29
518-524
2009
Oryctolagus cuniculus, Homo sapiens
Manually annotated by BRENDA team
Moore, R.M.; Novak, J.B.; Kumar, D.; Mansour, J.M.; Mercer, B.M.; Moore, J.J.
Alpha-lipoic acid inhibits tumor necrosis factor-induced remodeling and weakening of human fetal membranes
Biol. Reprod.
80
781-787
2009
Homo sapiens
Manually annotated by BRENDA team
Figueira, R.C.; Gomes, L.R.; Neto, J.S.; Silva, F.C.; Silva, I.D.; Sogayar, M.C.
Correlation between MMPs and their inhibitors in breast cancer tumor tissue specimens and in cell lines with different metastatic potential
BMC Cancer
9
20
2009
Homo sapiens (P14780), Homo sapiens
Manually annotated by BRENDA team
Peng, T.L.; Chen, J.; Mao, W.; Song, X.; Chen, M.H.
Aryl hydrocarbon receptor pathway activation enhances gastric cancer cell invasiveness likely through a c-Jun-dependent induction of matrix metalloproteinase-9
BMC Cell Biol.
10
27
2009
Homo sapiens
Manually annotated by BRENDA team
Zhou, L.; Yan, C.; Gieling, R.G.; Kida, Y.; Garner, W.; Li, W.; Han, Y.P.
Tumor necrosis factor-alpha induced expression of matrix metalloproteinase-9 through p21-activated kinase-1
BMC Immunol.
10
15
2009
Homo sapiens
Manually annotated by BRENDA team
Miyake, K.; Shimada, M.; Nishioka, M.; Sugimoto, K.; Batmunkh, E.; Uto, Y.; Nagasawa, H.; Hori, H.
Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer
Cancer Chemother. Pharmacol.
64
885-892
2009
Homo sapiens
Manually annotated by BRENDA team
Wu, J.M.; Sheng, H.; Saxena, R.; Skill, N.J.; Bhat-Nakshatri, P.; Yu, M.; Nakshatri, H.; Maluccio, M.A.
NF-kappaB inhibition in human hepatocellular carcinoma and its potential as adjunct to sorafenib based therapy
Cancer Lett.
278
145-155
2009
Homo sapiens
Manually annotated by BRENDA team
Bin Hafeez, B.; Adhami, V.M.; Asim, M.; Siddiqui, I.A.; Bhat, K.M.; Zhong, W.; Saleem, M.; Din, M.; Setaluri, V.; Mukhtar, H.
Targeted knockdown of Notch1 inhibits invasion of human prostate cancer cells concomitant with inhibition of matrix metalloproteinase-9 and urokinase plasminogen activator
Clin. Cancer Res.
15
452-459
2009
Homo sapiens
Manually annotated by BRENDA team
Bjarnegard, N.; Arnqvist, H.J.; Lindstroem, T.; Jonasson, L.; Joensson, A.; Laenne, T.
Long-term hyperglycaemia impairs vascular smooth muscle cell function in women with type 1 diabetes mellitus
Diab. Vasc. Dis. Res.
6
25-31
2009
Homo sapiens
Manually annotated by BRENDA team
Khademi, M.; Bornsen, L.; Rafatnia, F.; Andersson, M.; Brundin, L.; Piehl, F.; Sellebjerg, F.; Olsson, T.
The effects of natalizumab on inflammatory mediators in multiple sclerosis: prospects for treatment-sensitive biomarkers
Eur. J. Neurol.
16
528-536
2009
Homo sapiens
Manually annotated by BRENDA team
Choi, S.J.; Jung, K.L.; Oh, S.Y.; Kim, J.H.; Roh, C.R.
Cervicovaginal matrix metalloproteinase-9 and cervical ripening in human term parturition
Eur. J. Obstet. Gynecol. Reprod. Biol.
142
43-47
2009
Homo sapiens
Manually annotated by BRENDA team
Chen, Y.; Zhang, W.; Geng, N.; Tian, K.; Jack Windsor, L.
MMPs, TIMP-2, and TGF-beta1 in the cancerization of oral lichen planus
Head Neck
30
1237-1245
2008
Homo sapiens
Manually annotated by BRENDA team
Meijer, M.J.; Mieremet-Ooms, M.A.; Sier, C.F.; van Hogezand, R.A.; Lamers, C.B.; Hommes, D.W.; Verspaget, H.W.
Matrix metalloproteinases and their tissue inhibitors as prognostic indicators for diagnostic and surgical recurrence in Crohns disease
Inflamm. Bowel Dis.
15
84-92
2009
Homo sapiens
Manually annotated by BRENDA team
Saussez, S.; Cludts, S.; Capouillez, A.; Mortuaire, G.; Smetana, K.; Kaltner, H.; Andre, S.; Leroy, X.; Gabius, H.J.; Decaestecker, C.
Identification of matrix metalloproteinase-9 as an independent prognostic marker in laryngeal and hypopharyngeal cancer with opposite correlations to adhesion/growth-regulatory galectins-1 and -7
Int. J. Oncol.
34
433-439
2009
Homo sapiens
Manually annotated by BRENDA team
Cao, J.; Tang, M.; Li, W.L.; Xie, J.; Du, H.; Tang, W.B.; Wang, H.; Chen, X.W.; Xiao, H.; Li, Y.
Upregulation of activator protein-4 in human colorectal cancer with metastasis
Int. J. Surg. Pathol.
17
16-21
2009
Homo sapiens
Manually annotated by BRENDA team
Lawrence, B.J.; Maase, E.L.; Lin, H.K.; Madihally, S.V.
Multilayer composite scaffolds with mechanical properties similar to small intestinal submucosa
J. Biomed. Mater. Res. A
88
634-643
2009
Homo sapiens
Manually annotated by BRENDA team
Alapure, B.V.; Praveen, M.R.; Gajjar, D.; Vasavada, A.R.; Rajkumar, S.; Johar, K.
Matrix metalloproteinase-9 activity in human lens epithelial cells of cortical, posterior subcapsular, and nuclear cataracts
J. Cataract. Refract. Surg.
34
2063-2067
2008
Homo sapiens
Manually annotated by BRENDA team
Montagnana, M.; Lippi, G.; Albiero, A.; Scevarolli, S.; Salvagno, G.L.; Franchi, M.; Guidi, G.C.
Evaluation of metalloproteinases 2 and 9 and their inhibitors in physiologic and pre-eclamptic pregnancy
J. Clin. Lab. Anal.
23
88-92
2009
Homo sapiens
Manually annotated by BRENDA team
Itoh, T.; Nakamura, H.; Kishi, J.; Hayakawa, T.
The activation of matrix metalloproteinases by a whole-cell extract from Prevotella nigrescens
J. Endod.
35
55-59
2009
Homo sapiens
Manually annotated by BRENDA team
Zhao, X.; Town, J.R.; Li, F.; Zhang, X.; Cockcroft, D.W.; Gordon, J.R.
ELR-CXC chemokine receptor antagonism targets inflammatory responses at multiple levels
J. Immunol.
182
3213-3222
2009
Homo sapiens
Manually annotated by BRENDA team
Chung, I.M.; Ahmad, A.; Ali, M.; Lee, O.K.; Kim, M.Y.; Kim, J.H.; Yoon, D.Y.; Peebles, C.A.; San, K.Y.
Flavonoid glucosides from the hairy roots of Catharanthus roseus
J. Nat. Prod.
72
613-620
2009
Homo sapiens
Manually annotated by BRENDA team
Santra, M.; Santra, S.; Roberts, C.; Zhang, R.L.; Chopp, M.
Doublecortin induces mitotic microtubule catastrophe and inhibits glioma cell invasion
J. Neurochem.
108
231-245
2009
Homo sapiens
Manually annotated by BRENDA team
Castillo, J.; Alvarez-Sabin, J.; Martinez-Vila, E.; Montaner, J.; Sobrino, T.; Vivancos, J.; Vivancos, J.
Inflammation markers and prediction of post-stroke vascular disease recurrence: the MITICO study
J. Neurol.
256
217-224
2009
Homo sapiens
Manually annotated by BRENDA team
Poyer, F.; Coquerel, B.; Pegahi, R.; Cazin, L.; Norris, V.; Vannier, J.P.; Lamacz, M.
Secretion of MMP-2 and MMP-9 induced by VEGF autocrine loop correlates with clinical features in childhood acute lymphoblastic leukemia
Leuk. Res.
33
407-417
2009
Homo sapiens
Manually annotated by BRENDA team
Sen, T.; Moulik, S.; Dutta, A.; Choudhury, P.R.; Banerji, A.; Das, S.; Roy, M.; Chatterjee, A.
Multifunctional effect of epigallocatechin-3-gallate (EGCG) in downregulation of gelatinase-A (MMP-2) in human breast cancer cell line MCF-7
Life Sci.
84
194-204
2009
Homo sapiens
Manually annotated by BRENDA team
Solakivi, T.; Kunnas, T.; Kaerkkaeinen, S.; Jaakkola, O.; Nikkari, S.T.
Arachidonic acid increases matrix metalloproteinase 9 secretion and expression in human monocytic MonoMac 6 cells
Lipids Health Dis.
8
11
2009
Homo sapiens
Manually annotated by BRENDA team
Leung, J.C.; Chan, L.Y.; Tam, K.Y.; Tang, S.C.; Lam, M.F.; Cheng, A.S.; Chu, K.M.; Lai, K.N.
Regulation of CCN2/CTGF and related cytokines in cultured peritoneal cells under conditions simulating peritoneal dialysis
Nephrol. Dial. Transplant.
24
458-469
2009
Homo sapiens
Manually annotated by BRENDA team
Roomi, M.W.; Monterrey, J.C.; Kalinovsky, T.; Rath, M.; Niedzwiecki, A.
Distinct patterns of matrix metalloproteinase-2 and -9 expression in normal human cell lines
Oncol. Rep.
21
821-826
2009
Homo sapiens
Manually annotated by BRENDA team
Acera, A.; Rocha, G.; Vecino, E.; Lema, I.; Duran, J.A.
Inflammatory markers in the tears of patients with ocular surface disease
Ophthalmic Res.
40
315-321
2008
Homo sapiens
Manually annotated by BRENDA team
Vairaktaris, E.; Serefoglou, Z.; Avgoustidis, D.; Yapijakis, C.; Critselis, E.; Vylliotis, A.; Spyridonidou, S.; Derka, S.; Vassiliou, S.; Nkenke, E.; Patsouris, E.
Gene polymorphisms related to angiogenesis, inflammation and thrombosis that influence risk for oral cancer
Oral Oncol.
45
247-253
2009
Homo sapiens
Manually annotated by BRENDA team
Carneiro, E.; Menezes, R.; Garlet, G.P.; Garcia, R.B.; Bramante, C.M.; Figueira, R.; Sogayar, M.; Granjeiro, J.M.
Expression analysis of matrix metalloproteinase-9 in epithelialized and nonepithelialized apical periodontitis lesions
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.
107
127-132
2009
Homo sapiens
Manually annotated by BRENDA team
Lee, J.I.; Jin, B.H.; Kim, M.A.; Yoon, H.J.; Hong, S.P.; Hong, S.D.
Prognostic significance of CXCR-4 expression in oral squamous cell carcinoma
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.
107
678-684
2009
Homo sapiens
Manually annotated by BRENDA team
Baba, H.; Ohtsuka, Y.; Fujii, T.; Haruna, H.; Nagata, S.; Kobayashi, H.; Yamataka, A.; Shimizu, T.; Miyano, T.; Yamashiro, Y.
Immunological investigation of the hepatic tissue from infants with biliary atresia
Pediatr. Surg. Int.
25
157-162
2009
Homo sapiens
Manually annotated by BRENDA team
Seeger, F.H.; Chen, L.; Spyridopoulos, I.; Altschmied, J.; Aicher, A.; Haendeler, J.
Downregulation of ETS rescues diabetes-induced reduction of endothelial progenitor cells
PLoS ONE
4
e4529
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Higashimoto, Y.; Iwata, T.; Okada, M.; Satoh, H.; Fukuda, K.; Tohda, Y.
Serum biomarkers as predictors of lung function decline in chronic obstructive pulmonary disease
Respir. Med.
103
1231-1238
2009
Homo sapiens
Manually annotated by BRENDA team
Barlas, I.O.; Sezgin, M.; Erdal, M.E.; Sahin, G.; Ankarali, H.C.; Altintas, Z.M.; Tuerkmen, E.
Association of (-1,607) 1G/2G polymorphism of matrix metalloproteinase-1 gene with knee osteoarthritis in the Turkish population (knee osteoarthritis and MMPs gene polymorphisms)
Rheumatol. Int.
29
383-388
2009
Homo sapiens
Manually annotated by BRENDA team
Borthwick, L.A.; Parker, S.M.; Brougham, K.A.; Johnson, G.E.; Gorowiec, M.R.; Ward, C.; Lordan, J.; Corris, P.; Kirby, J.A.; Fisher, A.J.
Epithelial to mesenchymal transition (EMT) and airway remodelling after human lung transplantation
Thorax
64
770-777
2009
Homo sapiens
Manually annotated by BRENDA team
Yeh, M.H.; Kao, S.T.; Hung, C.M.; Liu, C.J.; Lee, K.H.; Yeh, C.C.
Hesperidin inhibited acetaldehyde-induced matrix metalloproteinase-9 gene expression in human hepatocellular carcinoma cells
Toxicol. Lett.
184
204-210
2009
Homo sapiens
Manually annotated by BRENDA team
Yanti, H.K.; Lee, M.; Kim, D.; Hwang, J.K.
Inhibitory effect of panduratin A on c-Jun N-terminal kinase and activator protein-1 signaling involved in Porphyromonas gingivalis supernatant-stimulated matrix metalloproteinase-9 expression in human oral epidermoid cells
Biol. Pharm. Bull.
32
1770-1775
2009
Homo sapiens
Manually annotated by BRENDA team
Grierson, C.; Miller, D.; Lapan, P.; Brady, J.
Utility of combining MMP-9 ELISA and MMP-9 activity assay data to monitor plasma enzyme specific-activity
Anal. Biochem.
404
232-234
2010
Homo sapiens
Manually annotated by BRENDA team
Zyada, M.M.
Expression of matrix metalloproteinase-9 and significance of a macrophage assay in eosinophilic granuloma
Ann. Diagn. Pathol.
13
367-372
2009
Homo sapiens
Manually annotated by BRENDA team
Chang, C.J.; Hsu, L.A.; Ko, Y.H.; Chen, P.L.; Chuang, Y.T.; Lin, C.Y.; Liao, C.H.; Pang, J.H.
Thrombin regulates matrix metalloproteinase-9 expression in human monocytes
Biochem. Biophys. Res. Commun.
385
241-246
2009
Homo sapiens
Manually annotated by BRENDA team
Gessi, S.; Sacchetto, V.; Fogli, E.; Merighi, S.; Varani, K.; Baraldi, P.G.; Tabrizi, M.A.; Leung, E.; Maclennan, S.; Borea, P.A.
Modulation of metalloproteinase-9 in U87MG glioblastoma cells by A3 adenosine receptors
Biochem. Pharmacol.
79
1483-1495
2010
Homo sapiens
Manually annotated by BRENDA team
Yanti, H.; Oh, H.I.; Anggakusuma, H.I.; Hwang, J.K.
Effects of panduratin A isolated from Kaempferia pandurata ROXB. on the expression of matrix metalloproteinase-9 by porphyromonas gingivalis supernatant-induced KB cells
Biol. Pharm. Bull.
32
110-115
2009
Homo sapiens
Manually annotated by BRENDA team
Xue, J.; Hua, Y.N.; Xie, M.L.; Gu, Z.L.
Aspirin inhibits MMP-9 mRNA expression and release via the PPARalpha/gamma and COX-2/mPGES-1-mediated pathways in macrophages derived from THP-1 cells
Biomed. Pharmacother.
64
118-123
2010
Homo sapiens
Manually annotated by BRENDA team
Tan, M.L.; Choong, P.F.; Dass, C.R.
Direct anti-metastatic efficacy by the DNA enzyme Dz13 and downregulated MMP-2, MMP-9 and MT1-MMP in tumours
Cancer Cell Int.
10
9-9
2010
Homo sapiens
Manually annotated by BRENDA team
Hung, W.C.; Tseng, W.L.; Shiea, J.; Chang, H.C.
Skp2 overexpression increases the expression of MMP-2 and MMP-9 and invasion of lung cancer cells
Cancer Lett.
288
156-161
2010
Homo sapiens
Manually annotated by BRENDA team
Takagi, S.; Simizu, S.; Osada, H.
RECK negatively regulates matrix metalloproteinase-9 transcription
Cancer Res.
69
1502-1508
2009
Homo sapiens
Manually annotated by BRENDA team
Massaro, M.; Zampolli, A.; Scoditti, E.; Carluccio, M.A.; Storelli, C.; Distante, A.; De Caterina, R.
Statins inhibit cyclooxygenase-2 and matrix metalloproteinase-9 in human endothelial cells: anti-angiogenic actions possibly contributing to plaque stability
Cardiovasc. Res.
86
311-320
2010
Homo sapiens
Manually annotated by BRENDA team
Lin, C.C.; Kuo, C.T.; Cheng, C.Y.; Wu, C.Y.; Lee, C.W.; Hsieh, H.L.; Lee, I.T.; Yang, C.M.
IL-1beta promotes A549 cell migration via MAPKs/AP-1- and NF-kappaB-dependent matrix metalloproteinase-9 expression
Cell. Signal.
21
1652-1662
2009
Homo sapiens
Manually annotated by BRENDA team
Chen, Y.J.; Chang, W.M.; Liu, Y.W.; Lee, C.Y.; Jang, Y.H.; Kuo, C.D.; Liao, H.F.
A small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloproteinase-9 expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells
Chem. Biol. Interact.
181
440-446
2009
Homo sapiens
Manually annotated by BRENDA team
Chou, Y.C.; Sheu, J.R.; Chung, C.L.; Chen, C.Y.; Lin, F.L.; Hsu, M.J.; Kuo, Y.H.; Hsiao, G.
Nuclear-targeted inhibition of NF-kappaB on MMP-9 production by N-2-(4-bromophenyl) ethyl caffeamide in human monocytic cells
Chem. Biol. Interact.
184
403-412
2010
Homo sapiens
Manually annotated by BRENDA team
Lee, E.J.; Kim, S.Y.; Hyun, J.W.; Min, S.W.; Kim, D.H.; Kim, H.S.
Glycitein inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression
Chem. Biol. Interact.
185
18-24
2010
Homo sapiens
Manually annotated by BRENDA team
Sakata, K.; Hamaoka, K.; Ozawa, S.; Niboshi, A.; Yahata, T.; Fujii, M.; Hamaoka, A.; Toiyama, K.; Nishida, M.; Itoi, T.
Matrix metalloproteinase-9 in vascular lesions and endothelial regulation in Kawasaki disease
Circ. J.
74
1670-1675
2010
Homo sapiens
Manually annotated by BRENDA team
Gai, X.; Lan, X.; Luo, Z.; Wang, F.; Liang, Y.; Zhang, H.; Zhang, W.; Hou, J.; Huang, M.
Association of MMP-9 gene polymorphisms with atrial fibrillation in hypertensive heart disease patients
Clin. Chim. Acta
408
105-109
2009
Homo sapiens
Manually annotated by BRENDA team
Marcaccini, A.M.; Novaes, A.B.; Meschiari, C.A.; Souza, S.L.; Palioto, D.B.; Sorgi, C.A.; Faccioli, L.H.; Tanus-Santos, J.E.; Gerlach, R.F.
Circulating matrix metalloproteinase-8 (MMP-8) and MMP-9 are increased in chronic periodontal disease and decrease after non-surgical periodontal therapy
Clin. Chim. Acta
409
117-122
2009
Homo sapiens
Manually annotated by BRENDA team
Anand, S.P.; Selvaraj, P.
Effect of 1, 25 dihydroxyvitamin D(3) on matrix metalloproteinases MMP-7, MMP-9 and the inhibitor TIMP-1 in pulmonary tuberculosis
Clin. Immunol.
133
126-131
2009
Homo sapiens
Manually annotated by BRENDA team
Zhao, S.; Choksuchat, C.; Zhao, Y.; Ballagh, S.A.; Kovalevsky, G.A.; Archer, D.F.
Effects of doxycycline on serum and endometrial levels of MMP-2, MMP-9 and TIMP-1 in women using a levonorgestrel-releasing subcutaneous implant
Contraception
79
469-478
2009
Homo sapiens
Manually annotated by BRENDA team
Dong, X.; Song, Y.N.; Liu, W.G.; Guo, X.L.
MMP-9, a potential target for cerebral ischemic treatment
Curr. Neuropharmacol.
7
269-275
2009
Homo sapiens
Manually annotated by BRENDA team
Pan, M.H.; Lin, Y.T.; Lin, C.L.; Wei, C.S.; Ho, C.T.; Chen, W.J.
Suppression of heregulin-beta1/HER2-modulated invasive and aggressive phenotype of breast carcinoma by pterostilbene via inhibition of matrix metalloproteinase-9, p38 kinase cascade and Akt activation
Evid. Based. Complement Alternat. Med.
2011
562187
2011
Homo sapiens
Manually annotated by BRENDA team
Mroczko, B.; Lukaszewicz-Zajac, M.; Guzinska-Ustymowicz, K.; Gryko, M.; Czyzewska, J.; Kemona, A.; Kedra, B.; Szmitkowski, M.
Expression of matrix metalloproteinase-9 in the neoplastic and interstitial inflammatory infiltrate cells in gastric cancer
Folia Histochem. Cytobiol.
47
491-496
2009
Homo sapiens
Manually annotated by BRENDA team
Choi, J.H.; Han, E.H.; Hwang, Y.P.; Choi, J.M.; Choi, C.Y.; Chung, Y.C.; Seo, J.K.; Jeong, H.G.
Suppression of PMA-induced tumor cell invasion and metastasis by aqueous extract isolated from Prunella vulgaris via the inhibition of NF-kappaB-dependent MMP-9 expression
Food Chem. Toxicol.
48
564-571
2010
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Bittner, A.; Alcaino, H.; Castro, P.F.; Perez, O.; Corbalan, R.; Troncoso, R.; Chiong, M.; Mellado, R.; Moraga, F.; Zanolli, D.; Winter, J.L.; Zamorano, J.J.; Diaz-Araya, G.; Lavandero, S.
Matrix metalloproteinase-9 activity is associated to oxidative stress in patients with acute coronary syndrome
Int. J. Cardiol.
143
98-100
2009
Homo sapiens
Manually annotated by BRENDA team
Huang, Z.; Wang, L.; Meng, S.; Wang, Y.; Chen, T.; Wang, C.
Berberine reduces both MMP-9 and EMMPRIN expression through prevention of p38 pathway activation in PMA-induced macrophages
Int. J. Cardiol.
146
153-158
2009
Homo sapiens
Manually annotated by BRENDA team
Tagami, K.; Yujiri, T.; Takahashi, T.; Kizuki, N.; Tanaka, Y.; Mitani, N.; Nakamura, Y.; Ariyoshi, K.; Ando, T.; Gondo, T.; Tanizawa, Y.
Increased serum levels of matrix metalloproteinase-9 in acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation
Int. J. Hematol.
90
248-252
2009
Homo sapiens
Manually annotated by BRENDA team
Cauwe, B.; Martens, E.; Proost, P.; Opdenakker, G.
Multidimensional degradomics identifies systemic autoantigens and intracellular matrix proteins as novel gelatinase B/MMP-9 substrates
Integr. Biol. (Camb.)
1
404-426
2009
Homo sapiens
Manually annotated by BRENDA team
Takagi, H.; Manabe, H.; Kawai, N.; Goto, S.N.; Umemoto, T.
Circulating matrix metalloproteinase-9 concentrations and abdominal aortic aneurysm presence: a meta-analysis
Interact. Cardiovasc. Thorac. Surg.
9
437-440
2009
Homo sapiens
Manually annotated by BRENDA team
Chotikavanich, S.; de Paiva, C.S.; Li, d.e..Q.; Chen, J.J.; Bian, F.; Farley, W.J.; Pflugfelder, S.C.
Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome
Invest. Ophthalmol. Vis. Sci.
50
3203-3209
2009
Homo sapiens
Manually annotated by BRENDA team
Kuo, P.T.; Lin, T.P.; Liu, L.C.; Huang, C.H.; Lin, J.K.; Kao, J.Y.; Way, T.D.
Penta-O-galloyl-beta-D-glucose suppresses prostate cancer bone metastasis by transcriptionally repressing EGF-induced MMP-9 expression
J. Agric. Food Chem.
57
3331-3339
2009
Homo sapiens
Manually annotated by BRENDA team
Ardi, V.C.; Van den Steen, P.E.; Opdenakker, G.; Schweighofer, B.; Deryugina, E.I.; Quigley, J.P.
Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway
J. Biol. Chem.
284
25854-25866
2009
Homo sapiens
Manually annotated by BRENDA team
Gaudet, J.G.; Yocum, G.T.; Lee, S.S.; Granat, A.; Mikami, M.; Connolly, E.S.; Heyer, E.J.
MMP-9 levels in elderly patients with cognitive dysfunction after carotid surgery
J. Clin. Neurosci.
17
436-440
2010
Homo sapiens
Manually annotated by BRENDA team
Montreekachon, P.; Chotjumlong, P.; Reutrakul, V.; Krisanaprakornkit, S.
Involvement of cytosolic phospholipase A2alpha in MMP-9 up-regulation
J. Dent. Res.
88
1031-1036
2009
Homo sapiens
Manually annotated by BRENDA team
Yanti, S.C.; Anggakusuma, S.C.; Gwon, S.H.; Hwang, J.K.
Kaempferia pandurata Roxb. inhibits Porphyromonas gingivalis supernatant-induced matrix metalloproteinase-9 expression via signal transduction in human oral epidermoid cells
J. Ethnopharmacol.
123
315-324
2009
Homo sapiens
Manually annotated by BRENDA team
Kim, S.; Kim, S.H.; Hur, S.M.; Lee, S.K.; Kim, W.W.; Kim, J.S.; Kim, J.H.; Choe, J.H.; Nam, S.J.; Lee, J.E.; Yang, J.H.
Silibinin prevents TPA-induced MMP-9 expression by down-regulation of COX-2 in human breast cancer cells
J. Ethnopharmacol.
126
252-257
2009
Homo sapiens
Manually annotated by BRENDA team
Sheng, F.; Cheng, L.; Zeng, Q.; Gao, W.
Increased expression and activity of MMP-9 in C-reactive protein-induced human THP-1 mononuclear cells is related to activation of nuclear factor kappa-B
J. Huazhong Univ. Sci. Technol. Med. Sci.
29
399-403
2009
Homo sapiens
Manually annotated by BRENDA team
Lolmede, K.; Campana, L.; Vezzoli, M.; Bosurgi, L.; Tonlorenzi, R.; Clementi, E.; Bianchi, M.E.; Cossu, G.; Manfredi, A.A.; Brunelli, S.; Rovere-Querini, P.
Inflammatory and alternatively activated human macrophages attract vessel-associated stem cells, relying on separate HMGB1- and MMP-9-dependent pathways
J. Leukoc. Biol.
85
779-787
2009
Homo sapiens
Manually annotated by BRENDA team
Catalan, V.; Gomez-Ambrosi, J.; Rodriguez, A.; Ramirez, B.; Silva, C.; Rotellar, F.; Gil, M.J.; Cienfuegos, J.A.; Salvador, J.; Fruehbeck, G.
Increased adipose tissue expression of lipocalin-2 in obesity is related to inflammation and matrix metalloproteinase-2 and metalloproteinase-9 activities in humans
J. Mol. Med.
87
803-813
2009
Homo sapiens
Manually annotated by BRENDA team
Fernandes, K.S.; Brum, D.G.; Sandrim, V.C.; Guerreiro, C.T.; Barreira, A.A.; Tanus-Santos, J.E.
Matrix metalloproteinase-9 genotypes and haplotypes are associated with multiple sclerosis and with the degree of disability of the disease
J. Neuroimmunol.
214
128-131
2009
Homo sapiens
Manually annotated by BRENDA team
Ichiyama, T.; Takahashi, Y.; Matsushige, T.; Kajimoto, M.; Fukunaga, S.; Furukawa, S.
Serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 levels in non-herpetic acute limbic encephalitis
J. Neurol.
256
1846-1850
2009
Homo sapiens
Manually annotated by BRENDA team
Amaro, S.; Obach, V.; Cervera, A.; Urra, X.; Gomez-Choco, M.; Planas, A.M.; Chamorro, A.
Course of matrix metalloproteinase-9 isoforms after the administration of uric acid in patients with acute stroke: a proof-of-concept study
J. Neurol.
256
651-656
2009
Homo sapiens
Manually annotated by BRENDA team
Cuadrado, E.; Rosell, A.; Penalba, A.; Slevin, M.; Alvarez-Sabin, J.; Ortega-Aznar, A.; Montaner, J.
Vascular MMP-9/TIMP-2 and neuronal MMP-10 up-regulation in human brain after stroke: a combined laser microdissection and protein array study
J. Proteome Res.
8
3191-3197
2009
Homo sapiens
Manually annotated by BRENDA team
Zhao, F.; Zhang, Q.; Kang, C.; Cui, X.; Wang, T.; Xu, P.; Zhou, X.; Liu, J.; Song, X.
Suppression of matrix metalloproteinase-9 expression by RNA interference inhibits SGC7901 gastric adenocarcinoma cell growth and invasion in vitro and in vivo
Med. Oncol.
27
774-784
2010
Homo sapiens
Manually annotated by BRENDA team
Madsen, E.L.; Bruun, J.M.; Skogstrand, K.; Hougaard, D.M.; Christiansen, T.; Richelsen, B.
Long-term weight loss decreases the nontraditional cardiovascular risk factors interleukin-18 and matrix metalloproteinase-9 in obese subjects
Metab. Clin. Exp.
58
946-953
2009
Homo sapiens
Manually annotated by BRENDA team
Zhi, H.; Wang, H.; Ren, L.; Shi, Z.; Peng, H.; Cui, L.; Ma, G.; Ye, X.; Feng, Y.; Shen, C.; Zhai, X.; Zhang, C.; Zen, K.; Liu, N.
Functional polymorphisms of matrix metallopeptidase-9 and risk of coronary artery disease in a Chinese population
Mol. Biol. Rep.
37
13-20
2010
Homo sapiens
Manually annotated by BRENDA team
Cheng, Y.C.; Kuo, W.W.; Wu, H.C.; Lai, T.Y.; Wu, C.H.; Hwang, J.M.; Wang, W.H.; Tsai, F.J.; Yang, J.J.; Huang, C.Y.; Chu, C.H.
ZAK induces MMP-2 activity via JNK/p38 signals and reduces MMP-9 activity by increasing TIMP-1/2 expression in H9c2 cardiomyoblast cells
Mol. Cell. Biochem.
325
69-77
2009
Homo sapiens
Manually annotated by BRENDA team
Kim, S.Y.; Woo, M.S.; Park, J.S.; Kim, H.S.
Regulation of matrix metalloproteinase-9 gene expression in MPP+- or 6-OHDA-treated human neuroblastoma SK-N-BE(2)C cells
Neurochem. Int.
56
437-442
2010
Homo sapiens
Manually annotated by BRENDA team
Rybakowski, J.K.; Skibinska, M.; Leszczynska-Rodziewicz, A.; Kaczmarek, L.; Hauser, J.
Matrix metalloproteinase-9 gene and bipolar mood disorder
Neuromolecular Med.
11
128-132
2009
Homo sapiens
Manually annotated by BRENDA team
Hadassah, J.; Bhuvaneshwari, N.; Rao, U.; Sehgal, P.K.
Evaluation of succinylated collagen bandage lenses in corneal healing by the expression of matrix metalloproteinases (MMP-2 and MMP-9) in tear fluid
Ophthalmic Res.
42
64-72
2009
Homo sapiens
Manually annotated by BRENDA team
Liu, C.J.; Chang, K.W.; Lin, S.C.; Cheng, H.W.
Presurgical serum levels of matrix metalloproteinase-9 and vascular endothelial growth factor in oral squamous cell carcinoma
Oral Oncol.
45
920-925
2009
Homo sapiens
Manually annotated by BRENDA team
Annabi, B.; Lachambre, M.P.; Plouffe, K.; Moumdjian, R.; Beliveau, R.
Propranolol adrenergic blockade inhibits human brain endothelial cells tubulogenesis and matrix metalloproteinase-9 secretion
Pharmacol. Res.
60
438-445
2009
Homo sapiens
Manually annotated by BRENDA team
Kim, S.; Choi, J.H.; Lim, H.I.; Lee, S.K.; Kim, W.W.; Kim, J.S.; Kim, J.H.; Choe, J.H.; Yang, J.H.; Nam, S.J.; Lee, J.E.
Silibinin prevents TPA-induced MMP-9 expression and VEGF secretion by inactivation of the Raf/MEK/ERK pathway in MCF-7 human breast cancer cells
Phytomedicine
16
573-580
2009
Homo sapiens
Manually annotated by BRENDA team
Shinto, L.; Marracci, G.; Baldauf-Wagner, S.; Strehlow, A.; Yadav, V.; Stuber, L.; Bourdette, D.
Omega-3 fatty acid supplementation decreases matrix metalloproteinase-9 production in relapsing-remitting multiple sclerosis
Prostaglandins Leukot. Essent. Fatty Acids
80
131-136
2009
Homo sapiens
Manually annotated by BRENDA team
Konrad, L.; Scheiber, J.A.; Schwarz, L.; Schrader, A.J.; Hofmann, R.
TGF-beta1 and TGF-beta2 strongly enhance the secretion of plasminogen activator inhibitor-1 and matrix metalloproteinase-9 of the human prostate cancer cell line PC-3
Regul. Pept.
155
28-32
2009
Homo sapiens
Manually annotated by BRENDA team
Jiang, Z.; Sui, T.; Wang, B.
Relationships between MMP-2, MMP-9, TIMP-1 and TIMP-2 levels and their pathogenesis in patients with lupus nephritis
Rheumatol. Int.
30
1219-1226
2009
Homo sapiens
Manually annotated by BRENDA team
Rybakowski, J.K.; Skibinska, M.; Kapelski, P.; Kaczmarek, L.; Hauser, J.
Functional polymorphism of the matrix metalloproteinase-9 (MMP-9) gene in schizophrenia
Schizophr. Res.
109
90-93
2009
Homo sapiens
Manually annotated by BRENDA team
Fujimura, M.; Watanabe, M.; Narisawa, A.; Shimizu, H.; Tominaga, T.
Increased expression of serum matrix metalloproteinase-9 in patients with moyamoya disease
Surg. Neurol.
72
476-480
2009
Homo sapiens
Manually annotated by BRENDA team
Reiss, M.J.; Han, Y.P.; Garcia, E.; Goldberg, M.; Yu, H.; Garner, W.L.
Matrix metalloproteinase-9 delays wound healing in a murine wound model
Surgery
147
295-302
2010
Homo sapiens
Manually annotated by BRENDA team
Rahko, E.; Kauppila, S.; Paeaekkoe, P.; Blanco, G.; Apaja-Sarkkinen, M.; Talvensaari-Mattila, A.; Turpeenniemi-Hujanen, T.; Jukkola, A.
Immunohistochemical study of matrix metalloproteinase 9 and tissue inhibitor of matrix metalloproteinase 1 in benign and malignant breast tissue--strong expression in intraductal carcinomas of the breast
Tumour Biol.
30
257-264
2009
Homo sapiens
Manually annotated by BRENDA team
Akers, W.J.; Xu, B.; Lee, H.; Sudlow, G.; Fields, G.B.; Achilefu, S.; Edwards, W.B.
Detection of MMP-2 and MMP-9 activity in vivo with a triple-helical peptide optical probe
Bioconjug. Chem.
23
656-663
2012
Homo sapiens
Manually annotated by BRENDA team
Oshitari, T.; Okuyama, Y.; Miyata, Y.; Kosano, H.; Takahashi, H.; Natsugari, H.
Nobiletin metabolites: synthesis and inhibitory activity against matrix metalloproteinase-9 production
Bioorg. Med. Chem. Lett.
21
4540-4544
2011
Homo sapiens
Manually annotated by BRENDA team
Tarr, G.P.; Williams, M.J.; Phillips, L.V.; van Rij, A.M.; Jones, G.T.
Pro-MMP-9/TIMP-1 ratio correlates poorly with a direct assessment of MMP-9 activity
Clin. Biochem.
44
1480-1482
2011
Homo sapiens
Manually annotated by BRENDA team
Ruggiero, E.; Toschi, E.; Federico, M.
The activity of matrix metalloproteinase-9 is part of the mechanism of cell-to-cell HIV-1 endocytosis in dendritic cells
Curr. Drug Discov. Technol.
8
112-118
2011
Homo sapiens
Manually annotated by BRENDA team
Deziel, B.A.; Patel, K.; Neto, C.; Gottschall-Pass, K.; Hurta, R.A.
Proanthocyanidins from the American Cranberry (Vaccinium macrocarpon) inhibit matrix metalloproteinase-2 and matrix metalloproteinase-9 activity in human prostate cancer cells via alterations in multiple cellular signalling pathways
J. Cell. Biochem.
111
742-754
2010
Homo sapiens
Manually annotated by BRENDA team
Wang, J.; O'Sullivan, S.; Harmon, S.; Keaveny, R.; Radomski, M.W.; Medina, C.; Gilmer, J.F.
Design of barbiturate-nitrate hybrids that inhibit MMP-9 activity and secretion
J. Med. Chem.
55
2154-2162
2012
Homo sapiens
Manually annotated by BRENDA team
Perng, D.W.; Chang, K.T.; Su, K.C.; Wu, Y.C.; Chen, C.S.; Hsu, W.H.; Tsai, C.M.; Lee, Y.C.
Matrix metalloprotease-9 induces transforming growth factor-beta1 production in airway epithelium via activation of epidermal growth factor receptors
Life Sci.
89
204-212
2011
Homo sapiens
Manually annotated by BRENDA team
Zaga-Clavellina, V.; Garcia-Lopez, G.; Flores-Pliego, A.; Merchant-Larios, H.; Vadillo-Ortega, F.
In vitro secretion and activity profiles of matrix metalloproteinases, MMP-9 and MMP-2, in human term extra-placental membranes after exposure to Escherichia coli
Reprod. Biol. Endocrinol.
9
13
2011
Homo sapiens
Manually annotated by BRENDA team
Vandooren, J.; Born, B.; Solomonov, I.; Zajac, E.; Saldova, R.; Senske, M.; Ugarte-Berzal, E.; Martens, E.; Van Den Steen, P.; Van Damme, J.; Garcia-Pardo, A.; Froeyen, M.; Deryugina, E.; Quigley, J.; Moestrup, S.; Rudd, P.; Sagi, I.; Opdenakker, G.
Circular trimers of gelatinase B/matrix metalloproteinase-9 constitute a distinct population of functional enzyme molecules differentially regulated by tissue inhibitor of metalloproteinases-1
Biochem. J.
465
259-270
2015
Homo sapiens (P14780)
Manually annotated by BRENDA team
Musumeci, G.; Magro, G.; Cardile, V.; Coco, M.; Marzagalli, R.; Castrogiovanni, P.; Imbesi, R.; Graziano, A.; Barone, F.; Di Rosa, M.; Castorina, S.; Castorina, A.
Characterization of matrix metalloproteinase-2 and -9, ADAM-10 and N-cadherin expression in human glioblastoma multiforme
Cell Tissue Res.
362
45-60
2015
Homo sapiens (P14780)
Manually annotated by BRENDA team
Bellini, T.; Trentini, A.; Manfrinato, M.; Tamborino, C.; Volta, C.; Di Foggia, V.; Fainardi, E.; Dallocchio, F.; Castellazzi, M.
Matrix metalloproteinase-9 activity detected in body fluids is the result of two different enzyme forms
J. Biochem.
151
493-499
2012
Homo sapiens (P14780)
Manually annotated by BRENDA team
Aston-Mourney, K.; Zraika, S.; Udayasankar, J.; Subramanian, S.; Green, P.; Kahn, S.; Hull, R.
Matrix metalloproteinase-9 reduces islet amyloid formation by degrading islet amyloid polypeptide
J. Biol. Chem.
288
3553-3559
2013
Homo sapiens (P14780), Homo sapiens, Mus musculus (P41245), Mus musculus, Mus musculus C57BL/6 x DBA/2 (P41245)
Manually annotated by BRENDA team
Zhao, J.; Li, G.; Zhao, Z.; Wang, J.; Gao, G.; He, S.
Matrix metalloproteinase-9 expression is increased in astrocytic glioma and associated with prognosis of patients
Jpn. J. Clin. Oncol.
42
1060-1065
2012
Homo sapiens (P14780), Homo sapiens
Manually annotated by BRENDA team
Meffert, P.; Tscheuschler, A.; Beyersdorf, F.; Heilmann, C.; Kocher, N.; Uffelmann, X.; Discher, P.; Rylski, B.; Siepe, M.; Kari, F.A.
Characterization of serum matrix metalloproteinase 2/9 levels in patients with ascending aortic aneurysms
Interact. Cardiovasc. Thorac. Surg.
24
20-26
2017
Homo sapiens (P14780)
Manually annotated by BRENDA team
Ugarte-Berzal, E.; Vandooren, J.; Bailon, E.; Opdenakker, G.; Garcia-Pardo, A.
Inhibition of MMP-9-dependent degradation of gelatin, but not other MMP-9 substrates, by the MMP-9 hemopexin domain blades 1 and 4
J. Biol. Chem.
291
11751-11760
2016
Homo sapiens (P14780)
Manually annotated by BRENDA team
Baez, I.B.; Sampieri, C.L.; Solano, F.C.; Martinez Cazares, M.T.; Montero, H.; Cuevas, R.Z.
Activity of matrix metalloproteinase 2 and 9 isoforms in sputum samples from individuals infected with M. tuberculosis
Microb. Pathog.
135
103607
2019
Homo sapiens (P14780), Homo sapiens
Manually annotated by BRENDA team
Abu Bakar, A.R.; Ripen, A.M.; Merican, A.F.; Mohamad, S.B.
Enzymatic inhibitory activity of Ficus deltoidea leaf extract on matrix metalloproteinase-2, 8 and 9
Nat. Prod. Res.
33
1765-1768
2019
Homo sapiens (P14780)
Manually annotated by BRENDA team
Mohseni, S.; Moghadam, T.T.; Dabirmanesh, B.; Khajeh, K.
Expression, purification, refolding and invitro recovery of active full length recombinant human gelatinase MMP-9 in Escherichia coli
Protein Expr. Purif.
126
42-48
2016
Homo sapiens (P14780), Homo sapiens
Manually annotated by BRENDA team
Nicolai, E.; Sinibaldi, F.; Sannino, G.; Lagana, G.; Basoli, F.; Licoccia, S.; Cozza, P.; Santucci, R.; Piro, M.C.
Omega-3 and omega-6 fatty acids act as inhibitors of the matrix metalloproteinase-2 and matrix metalloproteinase-9 activity
Protein J.
36
278-285
2017
Homo sapiens (P14780)
Manually annotated by BRENDA team