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Disease on EC 3.4.24.34 - neutrophil collagenase

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DISEASE
TITLE OF PUBLICATION
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Abortion, Habitual
Mapping themes trends and knowledge structure of trophoblastic invasion, a bibliometric analysis from 2012-2021.
Abortion, Spontaneous
Detection of MMP-9 and TIMP-3 mRNA expression in the villi of patients undergoing early spontaneous abortion: A report of 30 cases.
Genetic variation in matrix metalloproteinase MMP2 and MMP9 as a risk factor for idiopathic recurrent spontaneous abortions in an Indian population.
Matrix metalloproteinases 1, 2, 3 and 9 functional single-nucleotide polymorphisms in idiopathic recurrent spontaneous abortion.
Spontaneous abortion is preceded by an altered serum concentration of matrix metalloproteinases.
Acantholysis
The specific proteolysis hypothesis of pemphigus: does the song remain the same?
Acidosis
An in-silico strategy to explore neuroprotection by quercetin in cerebral ischemia: a novel hypothesis based on inhibition of matrix metalloproteinase (MMPs) and acid sensing ion channel 1a (ASIC1a).
Acne Vulgaris
Novel anti-acne actions of nadifloxacin and clindamycin that inhibit the production of sebum, prostaglandin E(2) and promatrix metalloproteinase-2 in hamster sebocytes.
Acquired Immunodeficiency Syndrome
A genetic polymorphism of matrix metalloproteinase 9 (MMP-9) affects the changes in circulating MMP-9 levels induced by highly active antiretroviral therapy in HIV patients.
Matrix metalloproteinase inhibitor COL-3 in the treatment of AIDS-related Kaposi's sarcoma: a phase I AIDS malignancy consortium study.
Matrix metalloproteinase-7, -8, -9, -25, and -26 and CD43, -45, and -68 cell-markers in HIV-infected patients' saliva and gingival tissue.
Randomized phase II trial of matrix metalloproteinase inhibitor COL-3 in AIDS-related Kaposi's sarcoma: an AIDS Malignancy Consortium Study.
The role of HIV-1 activated leukocyte adhesion mechanisms and matrix metalloproteinase secretion in AIDS pathogenesis (Review).
Acute Coronary Syndrome
Association of calcium channel blocker use and pregnancy-associated plasma protein-A among older adults with hypertension: results from the ilSIRENTE study.
Clinical significance of leukotriene b4 and extracellular matrix metalloproteinase inducer in acute coronary syndrome.
Comparison between metalloproteinases-2 and -9 in healthy subjects, diabetics, and subjects with acute coronary syndrome.
Doxycycline alters vascular smooth muscle cell adhesion, migration, and reorganization of fibrillar collagen matrices.
Low MMP-8/TIMP-1 reflects left ventricle impairment in takotsubo cardiomyopathy and high TIMP-1 may help to differentiate it from acute coronary syndrome.
Matrix metalloproteinases in acute coronary syndromes: A new therapeutic target?
Metalloproteinase-2 and -9 in diabetic and nondiabetic subjects during acute coronary syndromes.
Metalloproteinases in Diabetics and Nondiabetics during Acute Coronary Syndromes and after 3 Months.
Perspectives on the value of biomarkers in acute cardiac care and implications for strategic management.
Potential implications of matrix metalloproteinase-9 in assessment and treatment of coronary artery disease.
Practical implications of novel serum ELISA-assay for matrix metalloproteinase-8 in acute cardiac diagnostics.
Role of matrix metalloproteinases in coronary artery disease.
Serum Levels of Matrix Metalloproteinase (MMP) 9, a Risk Factor for Acute Coronary Syndrome, Are Reduced Independently of Serum MMP-3 by Anti-TNF-? Antibody (Infliximab) Therapy in Patients With Rheumatoid Arthritis.
Systemic versus coronary levels of inflammation in acute coronary syndromes.
The balance of serum matrix metalloproteinase-8 and its tissue inhibitor in acute coronary syndrome and its recurrence.
The measurement of circulating matrix metalloproteinase-8 and its tissue inhibitor and their association with inflammatory mediators in patients with acute coronary syndrome.
Usefulness of Plasma Matrix Metalloproteinase-3 Levels to Predict Myocardial Infarction in Men With and Without Acute Coronary Syndrome.
[Expression of extracellular matrix metalloproteinase inducer in the unstable plaque of patients with acute coronary syndrome].
[Implications of serum matrix metalloproteinase-8 elevation in patients with acute coronary syndrome]
[Inflammatory-destructive biomarkers of atherosclerotic plaques instability. Study of arterial wall and blood].
[Intravascular ultrasound study of coronary remodeling and determination of matrix metalloproteinase and hypersensitive C-reactive protein]
Acute Kidney Injury
Matrix metalloproteinase-9, 10, and stress hyperglycaemia in acute kidney injury.
[Application value of urinary IGFBP7 and TIMP-2 in acute kidney injury with decompensated hepatitis B virus-related liver cirrhosis].
Acute Lung Injury
Effects of Mesenchymal Stem Cell Therapy on the Time Course of Pulmonary Remodeling Depend on the Etiology of Lung Injury in Mice.
Ionizing radiation enhances matrix metalloproteinase-2 production in human lung epithelial cells.
Matrix metalloproteinase activity in pediatric acute lung injury.
Matrix metalloproteinase and elastase activities in LPS-induced acute lung injury in guinea pigs.
Matrix metalloproteinase inhibitor prevents acute lung injury after cardiopulmonary bypass.
Matrix metalloproteinase-8 inactivates macrophage inflammatory protein-1 alpha to reduce acute lung inflammation and injury in mice.
Matrix metalloproteinases and matrix metalloproteinase inhibitors in acute lung injury.
Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase.
Modulation of airway remodeling-associated mediators by the antifibrotic compound, pirfenidone, and the matrix metalloproteinase inhibitor, batimastat, during acute lung injury in mice.
The role of neutrophil collagenase in endotoxic acute lung injury.
Up-regulation of trypsin and mesenchymal MMP-8 during development of hyperoxic lung injury in the rat.
[Current progress of matrix metalloproteinase in acute lung injury following cardiopulmonary bypass]
[Effects of unfractionated heparin on expression of metalloproteinase-2 and -9 in acute lung injury rats].
[Expression of various matrix metalloproteinases in mice with hyperoxia induced acute lung injury.]
Adenocarcinoma
Association of functional polymorphisms in MMPs genes with gastric cardia adenocarcinoma and esophageal squamous cell carcinoma in high incidence region of North China.
Characterisation of a novel matrix metalloproteinase inhibitor on pancreatic adenocarcinoma cells in vitro and in an orthotopic pancreatic cancer model in vivo.
Clinicopathologic significance of fascin, extracellular matrix metalloproteinase inducer, and ezrin expressions in colorectal adenocarcinoma.
Comparative effects of selected plant polyphenols, gallic acid and epigallocatechin gallate, on matrix metalloproteinases activity in multidrug resistant MCF7/DOX breast cancer cells.
Comparative Role of Matrixins in Diagnostics of Parotid Gland Tumors.
Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group.
Concurrent PEDF deficiency and Kras mutation induce invasive pancreatic cancer and adipose-rich stroma in mice.
COX-2, MMP-9, and Noguchi classification provide additional prognostic information about adenocarcinoma of the lung. A study of 117 patients from Brazil.
Differential expression of matrix metalloproteinase (MMP)-2, MMP-9, and membrane type 1-MMP in hepatocellular and pancreatic adenocarcinoma: implications for tumor progression and clinical prognosis.
Differential matrix metalloproteinase levels in adenocarcinoma and squamous cell carcinoma of the lung.
EGF receptor antagonism improves survival in a murine model of pancreatic adenocarcinoma.
Expression of extracellular matrix metalloproteinase (MMP-9), E-cadherin and proliferation-associated antigen Ki-67 and their reciprocal correlation in canine mammary adenocarcinomas.
Expression of matrix metalloproteinase (gelatinase) in T1 adenocarcinoma of the lung.
Expression of membrane-type matrix metalloproteinase-1 in human pancreatic adenocarcinomas.
Helicobacter pylori potentiates epithelial:mesenchymal transition in gastric cancer: links to soluble HB-EGF, gastrin and matrix metalloproteinase-7.
Helicobacter pylori strain-selective induction of matrix metalloproteinase-7 in vitro and within gastric mucosa.
High Matrix Metalloproteinase 28 Expression is Associated with Poor Prognosis in Pancreatic Adenocarcinoma.
Human lung cancer cells grown in an ex vivo 3D lung model produce matrix metalloproteinases not produced in 2D culture.
Immunocytochemical detection of the expression of members of the matrix metalloproteinase family in adenocarcinomas of the pancreas.
Ingestion of proteoglycan fraction from shark cartilage increases serum inhibitory activity against matrix metalloproteinase-9 and suppresses development of N-nitrosobis(2-oxopropyl)amine-induced pancreatic duct carcinogenesis in hamster.
Inhibition of matrix metalloproteinase activity and growth of gastric adenocarcinoma cells by an angiotensin converting enzyme inhibitor in in vitro and murine models.
Inhibitory effect of a matrix metalloproteinase inhibitor on growth and spread of human pancreatic ductal adenocarcinoma evaluated in an orthotopic severe combined immunodeficient (SCID) mouse model.
Marimastat as maintenance therapy for patients with advanced gastric cancer: a randomised trial.
Matrix metalloproteinase (MMP)-7 in Barrett's esophagus and esophageal adenocarcinoma: expression, metabolism, and functional significance.
Matrix metalloproteinase 9 expression in primary human prostatic adenocarcinoma and benign prostatic hyperplasia.
Possible mechanisms of the crosstalk between Langerhans cells and regulatory T cells in extramammary Paget's disease by receptor activator of nuclear factor kappa-B ligand (RANKL)/ RANK pathways.
Prognostic significance of expression of matrix metalloproteinase in colorectal adenocarcinomas and their metastases.
Promoter hypermethylation of membrane type 3 matrix metalloproteinase is associated with cell migration in colorectal adenocarcinoma.
Regulation of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in MCF-7 cells: comparison with regulatory mechanisms of pS2 expression.
Regulation of tissue-degrading factors and in vitro invasiveness in progression of breast cancer cells.
Relationship between biomarker expression and allelic alteration in esophageal carcinoma.
Single nucleotide polymorphisms in the matrix metalloproteinase gene family and the frequency and duration of gastroesophageal reflux disease influence the risk of esophageal adenocarcinoma.
The Effect of Oral Administration of PUFAs on the Matrix Metalloproteinase Expression in Gastric Adenocarcinoma Patients Undergoing Chemotherapy.
The Expression of Matrix Metalloproteinases in Receptor Activator of Nuclear Factor Kappa-B Ligand (RANKL)-expressing Cancer of Apocrine Origin.
Adenocarcinoma of Lung
Allicin inhibits the invasion of lung adenocarcinoma cells by altering tissue inhibitor of metalloproteinase/matrix metalloproteinase balance via reducing the activity of phosphoinositide 3-kinase/AKT signaling.
Anti-angiogenic, apoptotic and matrix metalloproteinase inhibitory activity of Withania somnifera (ashwagandha) on lung adenocarcinoma cells.
Changes in tissue metalloproteinase inhibitor-1 and matrix metalloproteinases during tumor development and metastasizing in mice.
Curcumol inhibits lung adenocarcinoma growth and metastasis via inactivation of PI3K/AKT and Wnt/ß-catenin pathway.
Effects of simvastatin on cell viability and proinflammatory pathways in lung adenocarcinoma cells exposed to hydrogen peroxide.
Granulocyte, granulocyte-macrophage, and macrophage colony-stimulating factors can stimulate the invasive capacity of human lung cancer cells.
Interleukin-1 beta and transforming growth factor-beta 3 cooperate to activate matrix metalloproteinase expression and invasiveness in A549 lung adenocarcinoma cells.
PKC?, MMP?2 and MMP?9 expression in lung adenocarcinoma and association with a metastatic phenotype.
Sevoflurane inhibits invasion and migration of lung cancer cells by inactivating the p38 MAPK signaling pathway.
Significance of interstitial tumor-associated macrophages in the progression of lung adenocarcinoma.
Adenoma
Comparative Role of Matrixins in Diagnostics of Parotid Gland Tumors.
Cooperative effects of matrix metalloproteinase and cyclooxygenase-2 inhibition on intestinal adenoma reduction.
Detection of colorectal adenomas using a bioactivatable probe specific for matrix metalloproteinase activity.
Differential expression in normal-adenoma-carcinoma sequence suggests complex molecular carcinogenesis in colon.
Expression profiling of murine intestinal adenomas reveals early deregulation of multiple matrix metalloproteinase (Mmp) genes.
Significance of miR-148a in Colorectal Neoplasia: Downregulation of miR-148a Contributes to the Carcinogenesis and Cell Invasion of Colorectal Cancer.
The angiogenic switch of human colon cancer occurs simultaneous to initiation of invasion.
The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors.
The PEA3 subfamily of Ets transcription factors synergizes with beta-catenin-LEF-1 to activate matrilysin transcription in intestinal tumors.
Adenoma, Liver Cell
Distinction of hepatocellular adenoma from hepatocellular carcinoma with and without cirrhosis using E-cadherin and matrix metalloproteinase immunohistochemistry.
Adenoma, Pleomorphic
Comparative Role of Matrixins in Diagnostics of Parotid Gland Tumors.
Extracellular matrix metalloproteinase inducer expression in salivary gland tumors: a correlation with microvessel density.
Adenomatous Polyposis Coli
Relationship among expression of basic-fibroblast growth factor, MTDH/Astrocyte elevated gene-1, adenomatous polyposis coli, matrix metalloproteinase 9,and COX-2 markers with prognostic factors in prostate carcinomas.
Adenomyosis
A matrix metalloproteinase inhibitor, ONO-4817, retards the development of mammary tumor and the progression of uterine adenomyosis in mice.
Effect of matrix metalloproteinase promoter polymorphisms on endometriosis and adenomyosis risk: evidence from a meta-analysis.
Expression of Cyclooxygenase-2 and Matrix Metalloproteinase-2 in Adenomyosis and Endometrial Polyps and its Correlation With Angiogenesis.
Increased invasion activity of endometrial stromal cells and elevated expression of matrix metalloproteinase messenger RNA in the uterine tissues of mice with experimentally induced adenomyosis.
Suppression of the development of experimentally induced uterine adenomyosis by a novel matrix metalloproteinase inhibitor, ONO-4817, in mice.
[Expression of matrix metalloproteinase and tissue inhibitor of metalloproteinase in adenomyosis]
[Expression of the small molecular weight matrix metalloproteinase in adenomyosis of the mouse uterus]
Adrenal Cortex Neoplasms
Evaluation of MMP-1, MMP-8, MMP-9 serum levels in patients with adrenal tumors prior to and after surgery.
Adrenocortical Carcinoma
Matrix metalloproteinase type 2 expression in malignant adrenocortical tumors: Diagnostic and prognostic significance in a series of 50 adrenocortical carcinomas.
Aggressive Periodontitis
Collagenase activity in gingival crevicular fluid of patients with juvenile periodontitis.
Concentration of MMP-8 and IL-1? in gingival crevicular fluid in patients with chronic and aggressive periodontitis.
Effect of azithromycin, as an adjunct to nonsurgical periodontal treatment, on microbiological parameters and gingival crevicular fluid biomarkers in generalized aggressive periodontitis.
Effects of cranberry components on human aggressive periodontitis gingival fibroblasts.
Identification of polymorphonuclear leukocyte collagenase and gelatinase activities in mouthrinse samples: correlation with periodontal disease activity in adult and juvenile periodontitis.
Implant-safe test in patients with peri-implantitis.
Matrix Metalloproteinase (MMP)-8 and Tissue Inhibitors of Metalloproteinases (TIMP)-1 Gene Polymorphisms in Generalized Aggressive Periodontitis: GCF MMP-8 and TIMP-1 Levels and Outcome of Periodontal Therapy.
Matrix metalloproteinase levels in children with aggressive periodontitis.
MMP-8 -799 C>T genetic polymorphism is associated with the susceptibility to chronic and aggressive periodontitis in Taiwanese.
Periodontal Treatment Reduces Matrix Metalloproteinase Levels in Localized Aggressive Periodontitis.
Salivary collagenase, elastase- and trypsin-like proteases as biochemical markers of periodontal tissue destruction in adult and localized juvenile periodontitis.
Serum and salivary matrix metalloproteinases, neutrophil elastase, myeloperoxidase in patients with chronic or aggressive periodontitis.
Tetracycline inhibition identifies the cellular origin of interstitial collagenases in human periodontal diseases in vivo.
The effect of topical doxycycline usage on gingival crevicular fluid MMP-8 levels of chronic and aggressive periodontitis patients: a pilot study.
The Utility of Gingival Crevicular Fluid Matrix Metalloproteinase-8 Response Patterns in Prediction of Site Level Clinical Treatment Outcome.
Airway Obstruction
Airway obstruction correlates with collagenase-2 (MMP-8) expression and activation in bronchial asthma.
In vitro inhibition of matrix metalloproteinase activity in tracheal epithelial lining fluid from horses with recurrent airway obstruction.
Albuminuria
8D.08: MATRIX METALLOPROTEINASE (MMP) 2 AND MMP9 ACTIVITY IS INCREASED IN CONDITIONS OF ALBUMINURIA ESCAPE UNDER CHRONIC RENIN-ANGIOTENSIN SYSTEM SUPPRESSION.
CTGF inhibits BMP-7 signaling in diabetic nephropathy.
Finerenone Reduces Intrinsic Arterial Stiffness in Munich Wistar Frömter Rats, a Genetic Model of Chronic Kidney Disease.
Alveolar Bone Loss
Effects of Low Dose Doxycycline and Bisphosphonate Clodronate on Gingival Levels of Matrix Metalloproteinase -9, Interleukin -1B and Alveolar Bone Loss in Diabetic Rats. A Histomorphometric and Immunohistochemical Study.
Gelatinases and extracellular matrix metalloproteinase inducer are associated with cyclosporin-A-induced attenuation of periodontal degradation in rats.
Inhibition of alveolar bone loss by matrix metalloproteinase inhibitors in experimental periodontal disease.
Local administration of Tiludronic Acid downregulates important mediators involved in periodontal tissue destruction in experimental periodontitis in rats.
Local and systemic responses in matrix metalloproteinase 8-deficient mice during Porphyromonas gingivalis-induced periodontitis.
Morphometric and histopathological evaluation of the effect of grape seed proanthocyanidin on alveolar bone loss in experimental diabetes and periodontitis.
Alveolitis, Extrinsic Allergic
MMP2 Polymorphism Affects Plasma Matrix Metalloproteinase (MMP)-2 Levels, and Correlates with the Decline in Lung Function in Hypersensitivity Pneumonitis Positive to Autoantibodies Patients.
Alzheimer Disease
Disturbed Matrix Metalloproteinase Pathway in Both Age-Related Macular Degeneration and Alzheimer's Disease.
Expression of the type 1 metalloproteinase in the rat hippocampus after the intracerebroventricular injection of ?-amyloid peptide (25-35).
Genetic association between matrix metalloproteinase MMP-9 and MMP-3 polymorphisms and Japanese sporadic Alzheimer's disease.
Influence of plasma matrix metalloproteinase levels on longitudinal changes in Alzheimer's disease (AD) biomarkers and cognitive function in patients with mild cognitive impairment due to AD registered in the Alzheimer's Disease Neuroimaging Initiative database.
Matrix metalloproteinase-9 reduces islet amyloid formation by degrading islet amyloid polypeptide.
Proamyloidogenic effects of membrane type 1 matrix metalloproteinase involve MMP-2 and BACE-1 activities, and the modulation of APP trafficking.
Understanding the complexity of the matrix metalloproteinase system and its relevance to age-related diseases: Age-related macular degeneration and Alzheimer's disease.
Ameloblastoma
Comparative analysis of the immunohistochemical expression of collagen IV, MMP-9, and TIMP-2 in odontogenic cysts and tumors.
Epigenetic regulation of matrix metalloproteinase expression in ameloblastoma.
Invadopodia proteins, cortactin and membrane type I matrix metalloproteinase (MT1-MMP) are expressed in ameloblastoma.
MMP-7, -8, -9, E-cadherin, and beta-catenin expression in 34 ameloblastoma cases.
[Correlations of extrocellular matrix metalloproteinase inducer and microvessel density to invasiveness of ameloblastoma]
Amyloidosis
Doxycycline decreases amyloidogenic light chain-induced autophagy in isolated primary cardiac myocytes.
Aneurysm
A failure of matrix metalloproteinase inhibition in the prevention of rat intracranial aneurysm formation.
Abnormal extracellular matrix protein transport associated with increased apoptosis of vascular smooth muscle cells in marfan syndrome and bicuspid aortic valve thoracic aortic aneurysm.
Aneurysm growth, elastinolysis, and attempted doxycycline inhibition of elastase-induced aneurysms in rabbits.
Association of the matrix metalloproteinase-3 (-439C/G) promoter polymorphism with Kawasaki disease in Korean children.
Associations between serum relaxin 2, aneurysm formation/size and severity of atherosclerosis: a preliminary prospective analysis.
Azelnidipine decreases plasma matrix metalloproteinase-9 levels after endovascular abdominal aortic aneurysm repair.
Can matrix metalloproteinase inhibitors provide a realistic therapy in cardiovascular medicine?
Collagen degradation in the abdominal aneurysm: a conspiracy of matrix metalloproteinase and cysteine collagenases.
Crystal structure of full-length human collagenase 3 (MMP-13) with peptides in the active site defines exosites in the catalytic domain.
Deficiency of Endogenous Acute-Phase Serum Amyloid A Protects apoE-/- Mice From Angiotensin II-Induced Abdominal Aortic Aneurysm Formation.
Differences in Elastin and Elastolytic Enzymes between Men and Women with Abdominal Aortic Aneurysm.
Differential expression of genes in elastase-induced saccular aneurysms with high and low aspect ratios.
Does lipoprotein(a) inhibit elastolysis in abdominal aortic aneurysms?
Doxycycline alters vascular smooth muscle cell adhesion, migration, and reorganization of fibrillar collagen matrices.
Effect of angiotensin-converting enzyme inhibitor on matrix metalloproteinase-9 activity in patients with Kawasaki disease.
Effect of matrix metalloproteinase inhibition on progression of atherosclerosis and aneurysm in LDL receptor-deficient mice overexpressing MMP-3, MMP-12, and MMP-13 and on restenosis in rats after balloon injury.
Elastin-Derived Peptides Promote Abdominal Aortic Aneurysm Formation by Modulating M1/M2 Macrophage Polarization.
Enhanced embryonic nonmuscle myosin heavy chain isoform and matrix metalloproteinase expression in aortic abdominal aneurysm with rapid progression.
Extracellular matrix metalloproteinase inducer (EMMPRIN) is present in smooth muscle cells of human aneurysmal aorta and is induced by angiotensin II in vitro.
Extracellular proteolysis in the development and progression of atherosclerosis.
Heterogeneity of tensile strength and matrix metalloproteinase activity in the wall of abdominal aortic aneurysms.
Inflammatory Smooth Muscle Cells Induce Endothelial Cell Alterations to Influence Cerebral Aneurysm Progression via Regulation of Integrin and VEGF Expression.
Licochalcone A attenuates abdominal aortic aneurysm induced by angiotensin II via regulating the miR-181b/SIRT1/HO-1 signaling.
Long-term miR-29b suppression reduces aneurysm formation in a Marfan mouse model.
Loss of matrix metalloproteinase-9 or matrix metalloproteinase-12 protects apolipoprotein E-deficient mice against atherosclerotic media destruction but differentially affects plaque growth.
Matrix Metalloproteinase -2 and -9 Expression in the Wall of Saccular Cerebral Artery Aneurysm: Paper 54.
Matrix metalloproteinase 8 (neutrophil collagenase) in the pathogenesis of abdominal aortic aneurysm.
Matrix metalloproteinase and tissue inhibitor expression in atherosclerotic and nonatherosclerotic thoracic aortic aneurysms.
Matrix metalloproteinase haplotypes associated with coronary artery aneurysm formation in patients with Kawasaki disease.
Matrix metalloproteinases and descending aortic aneurysms: parity, disparity, and switch.
Molecular imaging of matrix metalloproteinase activation to predict murine aneurysm expansion in vivo.
Nitric oxide in experimental aneurysm formation: early events and consequences of nitric oxide inhibition.
Optical imaging of MMP-12 active form in inflammation and aneurysm.
Paracrine secretion of transforming growth factor-beta1 in aneurysm healing and stabilization with endovascular smooth muscle cell therapy.
Peroxisome Proliferator-Activated Receptor ? Level Contributes to Structural Integrity and Component Production of Elastic Fibers in the Aorta.
Plasma matrix metalloproteinase levels do not predict tissue levels in abdominal aortic aneurysms suitable for elective repair.
Relationship Between Circulating Plasma Matrix Metalloproteinase-9 (gelatinase-B) Concentration and Aortic Root Dilatation.
Response of plasma matrix metalloproteinases and tissue inhibitor of metalloproteinases to stent-graft surgery for descending thoracic aortic aneurysms.
Role of matrix metalloproteinases in abdominal aortic aneurysms.
Role of vascular endothelial growth factor-A in development of abdominal aortic aneurysm.
Systemic Administration of Ribbon-type Decoy Oligodeoxynucleotide Against Nuclear Factor ?B and Ets Prevents Abdominal Aortic Aneurysm in Rat Model.
The role of matrix metalloproteinases in vascular disease.
Thoracic aortic aneurysm: reading the enemy's playbook.
TIMP?3 suppresses the proliferation and migration of SMCs from the aortic neck of atherosclerotic AAA in rabbits, via decreased MMP?2 and MMP?9 activity, and reduced TNF?? expression.
[The role of estrogen in the formation and development of abdominal aortic aneurysm: experiment with rats]
Aneurysm, Dissecting
Collagen and elastin degradation by matrix metalloproteinases and tissue inhibitors of matrix metalloproteinase in aortic dissection.
Impact of matrix metalloproteinase-8 gene variations on the risk of thoracic aortic dissection in a Chinese Han population.
Matrix Metalloproteinase in Abdominal Aortic Aneurysm and Aortic Dissection.
Matrix metalloproteinase levels in acute aortic dissection, acute pancreatitis and other abdominal pain.
Matrix metalloproteinase levels in chronic thoracic aortic dissection.
Relationship Between Circulating Plasma Matrix Metalloproteinase-9 (gelatinase-B) Concentration and Aortic Root Dilatation.
Rule out of acute aortic dissection with plasma matrix metalloproteinase 8 in the emergency department.
The multitasking role of macrophages in Stanford type A acute aortic dissection.
The prominent expression of plasma matrix metalloproteinase-8 in acute thoracic aortic dissection.
Variants of genes encoding collagens and matrix metalloproteinase system increased the risk of aortic dissection.
Aneurysm, Ruptured
Comparative evaluation of genome-wide gene expression profiles in ruptured and unruptured human intracranial aneurysms.
Angina, Stable
Enhanced T-cell expression of RANK ligand in acute coronary syndrome: possible role in plaque destabilization.
Increased levels of leukocyte-derived MMP-9 in patients with stable angina pectoris.
Matrix metalloproteinase circulating levels, genetic polymorphisms, and susceptibility to acute myocardial infarction among patients with coronary artery disease.
Role of matrix metalloproteinases in coronary artery disease.
Serum tissue inhibitor of metalloproteinases-1 and higher risk features of coronary plaque: a volumetric multivessel intravascular ultrasound study.
[Implications of serum matrix metalloproteinase-8 elevation in patients with acute coronary syndrome]
[Intravascular ultrasound study of coronary remodeling and determination of matrix metalloproteinase and hypersensitive C-reactive protein]
[Measurement peripheral blood index related to inflammation and ox-LDL, ox-LDLAb in patients with coronary heart disease and its clinical significance]
Angina, Unstable
Enhanced T-cell expression of RANK ligand in acute coronary syndrome: possible role in plaque destabilization.
High plasma levels of matrix metalloproteinase-8 in patients with unstable angina.
[Comparison of right atrial matrix metalloproteinase expression between patients with unstable angina and myocardial infarction]
[Implications of serum matrix metalloproteinase-8 elevation in patients with acute coronary syndrome]
[Measurement peripheral blood index related to inflammation and ox-LDL, ox-LDLAb in patients with coronary heart disease and its clinical significance]
Angiofibroma
Expression of matrix metalloproteinases and their endogenous tissue inhibitors in skin lesions from patients with tuberous sclerosis.
Angiokeratoma
A case of angiokeratoma circumscriptum: immunolocalization of matrix metalloproteinase (MMP)-9.
Ankylosis
An extract from Myracrodruon urundeuva inhibits matrix mineralization in human osteoblasts.
Ankylosing spondylitis is characterized by an increased turnover of several different metalloproteinase-derived collagen species: a cross-sectional study.
Anthrax
Studies in mice reveal a role for anthrax toxin receptors in matrix metalloproteinase function and extracellular matrix homeostasis.
Aortic Aneurysm
Characterization of serum matrix metalloproteinase 2/9 levels in patients with ascending aortic aneurysms.
Dietary Supplementation with Omega-3 Polyunsaturated Fatty Acids Modulate Matrix Metalloproteinase Immunoreactivity in a Mouse Model of Pre-abdominal Aortic Aneurysm.
Effect of miR-21 on rat thoracic aortic aneurysm model by regulating the expressions of MMP-2 and MMP-9.
Effects of deletion of the tissue inhibitor of matrix metalloproteinases-1 gene on the progression of murine thoracic aortic aneurysms.
Effects of tissue inhibitor of metalloproteinase 2 deficiency on aneurysm formation.
Elevated messenger RNA expression and plasma protein levels of osteopontin and matrix metalloproteinase types 2 and 9 in patients with ascending aortic aneurysms.
Matrix metalloproteinase 8 (neutrophil collagenase) in the pathogenesis of abdominal aortic aneurysm.
Matrix metalloproteinases and descending aortic aneurysms: parity, disparity, and switch.
Mesenchymal stem cells attenuate angiotensin II-induced aortic aneurysm growth in apolipoprotein E-deficient mice.
SP600125 Attenuates Nicotine-Related Aortic Aneurysm Formation by Inhibiting Matrix Metalloproteinase Production and CC Chemokine-Mediated Macrophage Migration.
Systemic Delivery of Nanoparticles Loaded with Pentagalloyl Glucose Protects Elastic Lamina and Prevents Abdominal Aortic Aneurysm in Rats.
[Effect of nifedipine on organ protection: potential application in patients with aortic aneurysm]
Aortic Aneurysm, Abdominal
A Novel Histone Deacetylase Inhibitor Reduces Abdominal Aortic Aneurysm Formation in Angiotensin II-Infused Apolipoprotein E-Deficient Mice.
Abdominal aortic aneurysm rupture is associated with increased medial neovascularization and overexpression of proangiogenic cytokines.
Activity of matrix metalloproteinase-2 and -9 in abdominal aortic aneurysms. Relation to size and rupture.
Association of Matrix Metalloproteinase Levels with Collagen Degradation in the Context of Abdominal Aortic Aneurysm.
Atorvastatin modulates matrix metalloproteinase expression, activity, and signaling in abdominal aortic aneurysms.
Azelnidipine decreases plasma matrix metalloproteinase-9 levels after endovascular abdominal aortic aneurysm repair.
Circulating biomarkers of extracellular matrix remodeling and risk of atherosclerotic events.
Cross-talk between macrophages, smooth muscle cells, and endothelial cells in response to cigarette smoke: the effects on MMP2 and 9.
Different drugs effect on mesenchimal stem cells isolated from abdominal aortic aneurysm.
Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms.
Differential regulation of matrix metalloproteinase activities in abdominal aortic aneurysms.
Does lipoprotein(a) inhibit elastolysis in abdominal aortic aneurysms?
Early growth response factor-1 DNA enzyme 1 inhibits the formation of abdominal aortic aneurysm in rats.
Effect of hyperbaric oxygen treatment in a rat model of abdominal aortic aneurysm.
Effects of chymase inhibitor on angiotensin II-induced abdominal aortic aneurysm development in apolipoprotein E-deficient mice.
Elevated MMP-8 and decreased myeloperoxidase concentrations associate significantly with the risk for peripheral atherosclerosis disease and abdominal aortic aneurysm.
Expression of matrix metalloproteinases and their inhibitors in aneurysms and normal aorta.
Genotype-phenotype relationships in an investigation of the role of proteases in abdominal aortic aneurysm expansion.
Heterogeneity of tensile strength and matrix metalloproteinase activity in the wall of abdominal aortic aneurysms.
Hypoxia in Abdominal Aortic Aneurysm Supports a Role for HIF-1? and Ets-1 as Drivers of Matrix Metalloproteinase Upregulation in Human Aortic Smooth Muscle Cells.
Immune cells and molecular mediators in the pathogenesis of the abdominal aortic aneurysm.
Immunohistochemical expression of metalloproteinases MMP-2 and MMP-9 in abdominal aortic aneurysms: correlation with symptoms and aortic diameter.
In vivo optical molecular imaging of matrix metalloproteinase activity in abdominal aortic aneurysms correlates with treatment effects on growth rate.
Increased angiogenesis at the site of abdominal aortic aneurysm rupture.
Inhibition of EP4 signaling attenuates aortic aneurysm formation.
Isoflavone Ameliorated Oxidative Stress and Vascular Damages in Nicotine-Administrated Mice.
Levo-Tetrahydropalmatine Attenuates Progression of Abdominal Aortic Aneurysm in an Elastase Perfusion Rat Model via Suppression of Matrix Metalloproteinase and Monocyte Chemotactic Protein-1.
Localization of matrix metalloproteinase 2 within the aneurysmal and normal aortic wall.
Matrix metalloproteinase 8 (neutrophil collagenase) in the pathogenesis of abdominal aortic aneurysm.
Matrix metalloproteinase activity in thoracic aortic aneurysms associated with bicuspid and tricuspid aortic valves.
Matrix Metalloproteinase in Abdominal Aortic Aneurysm and Aortic Dissection.
Matrix metalloproteinase-8 and -9 are increased at the site of abdominal aortic aneurysm rupture.
Matrix metalloproteinases in ascending aortic aneurysms: bicuspid versus trileaflet aortic valves.
Matrix metalloproteinases in the aneurysm wall of patients treated with low-dose doxycycline.
MMP-12 has a role in abdominal aortic aneurysms in mice.
Monocyte activity is linked with abdominal aortic aneurysm diameter.
Multiple sites of vascular dilation or aneurysmal disease and matrix metalloproteinase genetic variants in patients with abdominal aortic aneurysm.
Nitric oxide induces the progression of abdominal aortic aneurysms through the matrix metalloproteinase inducer EMMPRIN.
Pathogenesis of abdominal aortic aneurysms: possible role of differential production of proteoglycans by smooth muscle cells.
Plasma matrix metalloproteinase levels do not predict tissue levels in abdominal aortic aneurysms suitable for elective repair.
Polymorphisms of the matrix metalloproteinase 9 gene and abdominal aortic aneurysm.
Presence of Chlamydia pneumoniae in abdominal aortic aneurysms is not associated with increased activity of matrix metalloproteinases.
Preservation of rabbit aorta elastin from degradation by gingival fibroblasts in an ex vivo model.
Prevention of abdominal aortic aneurysm progression by targeted inhibition of matrix metalloproteinase activity with batimastat-loaded nanoparticles.
Putative targeting of matrix metalloproteinase-8 in atherosclerosis.
RANKL-mediated osteoclastogenic differentiation of macrophages in the abdominal aorta of angiotensin II-infused apolipoprotein E knockout mice.
Relaxin and Matrix Metalloproteinase-9 in Angiotensin II-Induced Abdominal Aortic Aneurysms.
Role of matrix metalloproteinase inhibitors in preventing abdominal aortic aneurysm.
Significance of Matrix Metalloproteinase-9 Inhibition by Imidapril for Prevention of Abdominal Aortic Aneurysms in Angiotensin II Type 1 Receptor-Knockout Mice.
Suppression of experimental abdominal aortic aneurysms by systemic treatment with a hydroxamate-based matrix metalloproteinase inhibitor (RS 132908).
The matrix metalloproteinase inhibitor BB-94 limits expansion of experimental abdominal aortic aneurysms.
The role of cytokine gene polymorphisms in the pathogenesis of abdominal aortic aneurysms: a case-control study.
Validated UHPLC-MS/MS method for quantification of doxycycline in abdominal aortic aneurysm patients.
Aortic Aneurysm, Thoracic
A biologic basis for asymmetric growth in descending thoracic aortic aneurysms: a role for matrix metalloproteinase 9 and 2.
Correlation between MMP and TIMP levels and elastic moduli of ascending thoracic aortic aneurysms.
Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valves.
Increased tissue microarray matrix metalloproteinase expression favors proteolysis in thoracic aortic aneurysms and dissections.
Long-term effects of losartan on structure and function of the thoracic aorta in a mouse model of Marfan syndrome.
Low transcriptional activity haplotype of matrix metalloproteinase 1 is less frequent in bicuspid aortic valve patients.
Matrix metalloproteinase activity in thoracic aortic aneurysms associated with bicuspid and tricuspid aortic valves.
Matrix metalloproteinase and tissue inhibitor expression in atherosclerotic and nonatherosclerotic thoracic aortic aneurysms.
Regulation of membrane type-1 matrix metalloproteinase activity and intracellular localization in clinical thoracic aortic aneurysms.
Response of plasma matrix metalloproteinases and tissue inhibitor of metalloproteinases to stent-graft surgery for descending thoracic aortic aneurysms.
Temporal disparity in the induction of matrix metalloproteinases and tissue inhibitors of metalloproteinases after thoracic aortic aneurysm formation.
Aortic Diseases
Blocking the ERK1/2 signal pathway can inhibit S100A12 induced human aortic smooth muscle cells damage.
Medical treatment for thoracic aortic aneurysm - much more work to be done.
Aortic Valve Disease
Matrix metalloproteinase inhibitor, doxycycline and progression of calcific aortic valve disease in hyperlipidemic mice.
Multimodality and molecular imaging of matrix metalloproteinase activation in calcific aortic valve disease.
Aortic Valve Stenosis
Circulating matrix metalloproteinase patterns in association with aortic dilatation in bicuspid aortic valve patients with isolated severe aortic stenosis.
Extracellular matrix metalloproteinase inducer (CD147) and membrane type 1-matrix metalloproteinase are expressed on tissue macrophages in calcific aortic stenosis and induce transmigration in an artificial valve model.
Interleukin-1 beta promotes matrix metalloproteinase expression and cell proliferation in calcific aortic valve stenosis.
Matrix metalloproteinase expression in nonrheumatic aortic stenosis.
Appendicitis
Biomarkers to estimate the probability of complicated appendicitis.
Can new inflammatory markers improve the diagnosis of acute appendicitis?
Matrix metalloproteinase levels in peritoneal effluents were increased in a patient with appendicitis undergoing continuous ambulatory peritoneal dialysis.
Systemic Th17-like cytokine pattern in gangrenous appendicitis but not in phlegmonous appendicitis.
Arrhythmias, Cardiac
Anti-arrhythmic and anti-heart failure effects of low-level electrical stimulation on aortic root ventricular ganglionated plexi.
Arteriovenous Fistula
Matrix metalloproteinase inhibition limits arterial enlargements in a rodent arteriovenous fistula model.
Remodeling of experimental arteriovenous fistula with increased matrix metalloproteinase expression in rats.
Vein tissue expression of matrix metalloproteinase as biomarker for hemodialysis arteriovenous fistula maturation.
Arteriovenous Malformations
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Imbalance of matrix metalloproteinase-9 and matrix metalloproteinase tissue inhibitor-1 may contribute to hemorrhage in cerebellar arteriovenous malformations.
Matrix metalloproteinase-9 inhibition attenuates vascular endothelial growth factor-induced intracerebral hemorrhage.
Arteritis
Inhibition of matrix metalloproteinase-9 activity improves coronary outcome in an animal model of Kawasaki disease.
MMP-12, a novel matrix metalloproteinase associated with giant cell arteritis.
Arthralgia
A phase I and pharmacologic study of the matrix metalloproteinase inhibitor CP-471,358 in patients with advanced solid tumors.
A randomized phase II feasibility trial of BMS-275291 in patients with early stage breast cancer.
The gene expression profile of matrix metalloproteinases and their inhibitors in children with Henoch-Schönlein purpura.
Arthritis
A correlation between knee cartilage degradation observed by arthroscopy and synovial proteinases activities.
A novel approach to measure the contribution of matrix metalloproteinase in the overall net proteolytic activity present in synovial fluids of patients with arthritis.
A Randomized Phase II Trial of the Matrix Metalloproteinase Inhibitor BMS-275291 in Hormone-Refractory Prostate Cancer Patients with Bone Metastases.
Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent.
Arylsulfonamides and selectivity of matrix metalloproteinase-2: An overview.
Arylsulphonyl hydroxamic acids: potent and selective matrix metalloproteinase inhibitors.
Assignments, secondary structure and dynamics of the inhibitor-free catalytic fragment of human fibroblast collagenase.
Baicalein Attenuates Oxidative Stress-Induced Expression of Matrix Metalloproteinase-1 by Regulating the ERK/JNK/AP-1 Pathway in Human Keratinocytes.
Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding.
BRAF splice variants in rheumatoid arthritis synovial fibroblasts activate MAPK through CRAF.
CCR5 silencing reduces inflammatory response, inhibits viability, and promotes apoptosis of synovial cells in rat models of rheumatoid arthritis through the MAPK signaling pathway.
Celastrus-derived Celastrol suppresses autoimmune arthritis by modulating antigen-induced cellular and humoral effector responses.
Changes in the concentration of plasma matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases-1 (TIMP-1) after total joint replacement in patients with arthritis.
Chimeric anti-IL-17 full-length monoclonal antibody is a novel potential candidate for the treatment of rheumatoid arthritis.
Cleavage of aggrecan at the Asn341-Phe342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis: a pivotal role for stromelysin 1 in matrix metalloproteinase activity.
Collagenase, cathepsin B and cathepsin L gene expression in the synovial membrane of patients with early inflammatory arthritis.
Combined structure- and ligand-based pharmacophore modeling and molecular dynamics simulation studies to identify selective inhibitors of MMP-8.
Crocin exerts anti-inflammatory and anti-arthritic effects on type II collagen-induced arthritis in rats.
Crystal structure of full-length human collagenase 3 (MMP-13) with peptides in the active site defines exosites in the catalytic domain.
Curcumin: a potential candidate for matrix metalloproteinase inhibitors.
Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models.
Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3).
Development of temporomandibular joint arthritis: The use of animal models.
Dieckol from Ecklonia cava Regulates Invasion of Human Fibrosarcoma Cells and Modulates MMP-2 and MMP-9 Expression via NF-?B Pathway.
Early diagnosis of arthritis in mice with collagen-induced arthritis, using a fluorogenic matrix metalloproteinase 3-specific polymeric probe.
Elevated serum receptor activator of NFkappaB ligand (RANKL), osteoprotegerin (OPG), matrix metalloproteinase (MMP)3, and ProMMP1 in patients with juvenile idiopathic arthritis.
Experimental arthritis in rats induces biomarkers of periodontitis which are ameliorated by gene therapy with tissue inhibitor of matrix metalloproteinases.
Expression levels of matrix metalloproteinase (MMP)-9 and its specific inhibitor TIMP-1, in septic and aseptic arthritis of the knee.
Expression of Cannabinoid Receptors in Human Osteoarthritic Cartilage: Implications for Future Therapies.
Expression of matrix metalloproteinase 9 (96-kd gelatinase B) in human rheumatoid arthritis.
Hydrolysis of triple-helical collagen peptide models by matrix metalloproteinases.
Impressic acid from Acanthopanax koreanum, possesses matrix metalloproteinase-13 down-regulating capacity and protects cartilage destruction.
Inhibition of Matrix Metalloproteinase-3 and -13 Synthesis Induced by IL-1{beta} in Chondrocytes from Mice Lacking Microsomal Prostaglandin E Synthase-1.
Inhibition of transcription factors by plant-derived compounds and their implications in inflammation and cancer.
Insight towards the conserved water mediated recognition of catalytic and structural Zn(+2) ions in human Matrix Metalloproteinase-8 enzyme: A study by MD-simulation methods.
Interferon-gamma inhibits interleukin-1beta-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis.
Interleukin-1 beta induction of c-fos and collagenase expression in articular chondrocytes: involvement of reactive oxygen species.
Intraarticular induction of interleukin-1beta expression in the adult mouse, with resultant temporomandibular joint pathologic changes, dysfunction, and pain.
Involvement of 15-lipoxygenase in the inflammatory arthritis.
JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis.
Levels of matrix metalloproteinase (MMP)-1 in paired sera and synovial fluids of juvenile idiopathic arthritis patients: relationship to inflammatory activity, MMP-3 and tissue inhibitor of metalloproteinases-1 in a longitudinal study.
Levels of Selected Matrix Metalloproteinases, Their Inhibitors in Saliva, and Oral Status in Juvenile Idiopathic Arthritis Patients vs. Healthy Controls.
Local expression of the serum amyloid A and formyl peptide receptor-like 1 genes in synovial tissue is associated with matrix metalloproteinase production in patients with inflammatory arthritis.
Matrix metalloproteinase 8 deficiency in mice exacerbates inflammatory arthritis through delayed neutrophil apoptosis and reduced caspase 11 expression.
Matrix metalloproteinase inhibitors (MMPIs) from marine natural products: the current situation and future prospects.
Matrix metalloproteinase inhibitors in arthritis.
Matrix metalloproteinase inhibitors in the treatment of arthritis: comment on the article by Vincenti et al.
Matrix metalloproteinase-8 deficiency increases joint inflammation and bone erosion in the K/BxN serum-transfer arthritis model.
Moderation of iodoacetate-induced experimental osteoarthritis in rats by matrix metalloproteinase inhibitors.
NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-gamma-stimulated immune complex arthritis.
New biochemical insight of conserved water molecules at catalytic and structural Zn(2+) ions in human matrix metalloproteinase-I: a study by MD-simulation.
Novel inhibitors of matrix metalloproteinase gene expression as potential therapies for arthritis.
Novel Potent Proline-Based Metalloproteinase Inhibitors: Design, (Radio)Synthesis, and First in Vivo Evaluation as Radiotracers for Positron Emission Tomography.
Orally active MMP-1 sparing ?-tetrahydropyranyl and ?-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease.
PEP-1-FK506BP12 inhibits matrix metalloproteinase expression in human articular chondrocytes and in a mouse carrageenan-induced arthritis model.
Phlorotannins in Ecklonia cava extract inhibit matrix metalloproteinase activity.
Prevention of progressive joint destruction in adjuvant induced arthritis in rats by a novel matrix metalloproteinase inhibitor, FR217840.
Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-Terminal kinase pathway.
Regulation of MMP-9 by p53 in first trimester cytotrophoblastic cells.
Relationship between radiographic grading of osteoarthritis and the biochemical markers for arthritis in knee osteoarthritis.
Rheumatoid arthritis and salivary biomarkers of periodontal disease.
Role of the conserved histidine and aspartic acid residues in activity and stabilization of human gelatinase B: an example of matrix metalloproteinases.
Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages.
Solution structure of the catalytic domain of human stromelysin complexed with a hydrophobic inhibitor.
Stromal cell-derived factor-1 induces matrix metalloprotease-13 expression in human chondrocytes.
Structural insights on druggable hotspots in CD147: A bull's eye view.
Sulphonamides: Deserving class as MMP inhibitors?
Suppression of hyaluronan synthesis alleviates inflammatory response in murine arthritis and in human rheumatoid synovial fibroblasts.
Synovial fluid RANKL and matrix metalloproteinase levels in enthesitis related arthritis subtype of juvenile idiopathic arthritis.
The inhibition of metalloproteinases as a therapeutic target in rheumatoid arthritis and osteoarthritis.
The role of matrix metalloproteinase-2 promoter polymorphisms in coronary artery disease and myocardial infarction.
Thioredoxin fusion construct enables high-yield production of soluble, active matrix metalloproteinase-8 (MMP-8) in Escherichia coli.
Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1.
Use of Edman degradation sequence analysis and matrix-assisted laser desorption/ionization mass spectrometry in designing substrates for matrix metalloproteinases.
[Diagnostic utility of anti-cyclic citrullinated peptide antibody in early rheumatoid arthritis]
Arthritis, Experimental
Administration of systemic matrix metalloproteinase inhibitors maintains bone mechanical integrity in adjuvant arthritis.
Astilbin suppresses collagen-induced arthritis via the dysfunction of lymphocytes.
Blockade of integrin VLA-4 prevents inflammation and matrix metalloproteinase expression in a murine model of accelerated collagen-induced arthritis.
Correction to: Flavonoid quercetin-methotrexate combination inhibits inflammatory mediators and matrix metalloproteinase expression, providing protection to joints in collagen-induced arthritis.
Early diagnosis of arthritis in mice with collagen-induced arthritis, using a fluorogenic matrix metalloproteinase 3-specific polymeric probe.
Flavonoid quercetin-methotrexate combination inhibits inflammatory mediators and matrix metalloproteinase expression, providing protection to joints in collagen-induced arthritis.
Inhibition of cartilage and bone destruction in adjuvant arthritis in the rat by a matrix metalloproteinase inhibitor.
Oral administration of curcumin suppresses production of matrix metalloproteinase (MMP)-1 and MMP-3 to ameliorate collagen-induced arthritis: inhibition of the PKCdelta/JNK/c-Jun pathway.
Prevention of progressive joint destruction in collagen-induced arthritis in rats by a novel matrix metalloproteinase inhibitor, FR255031.
Tenidap and flurbiprofen enhance uptake of matrix metalloproteinase inhibitor 4-dedimethylaminotetracycline in inflamed joints of adjuvant arthritic rats.
Tetracyclines suppress matrix metalloproteinase activity in adjuvant arthritis and in combination with flurbiprofen, ameliorate bone damage.
Tumor necrosis factor receptor pre-ligand assembly domain is an important therapeutic target in inflammatory arthritis.
Arthritis, Juvenile
Elevated serum receptor activator of NFkappaB ligand (RANKL), osteoprotegerin (OPG), matrix metalloproteinase (MMP)3, and ProMMP1 in patients with juvenile idiopathic arthritis.
Levels of matrix metalloproteinase (MMP)-1 in paired sera and synovial fluids of juvenile idiopathic arthritis patients: relationship to inflammatory activity, MMP-3 and tissue inhibitor of metalloproteinases-1 in a longitudinal study.
Levels of Selected Matrix Metalloproteinases, Their Inhibitors in Saliva, and Oral Status in Juvenile Idiopathic Arthritis Patients vs. Healthy Controls.
Synovial fluid RANKL and matrix metalloproteinase levels in enthesitis related arthritis subtype of juvenile idiopathic arthritis.
Arthritis, Psoriatic
Increased serum TWEAK levels in Psoriatic arthritis: relationship with disease activity and matrix metalloproteinase-3 serum levels.
Arthritis, Reactive
In vivo inhibition of human neutrophil collagenase (MMP-8) activity during long-term combination therapy of doxycycline and non-steroidal anti-inflammatory drugs (NSAID) in acute reactive arthritis.
Reduction of matrix metalloproteinase 8-neutrophil collagenase levels during long-term doxycycline treatment of reactive arthritis.
Arthritis, Rheumatoid
A high throughput fluorogenic substrate for interstitial collagenase (MMP-1) and gelatinase (MMP-9).
A high throughput fluorogenic substrate for stromelysin (MMP-3).
A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 8 (neutrophil collagenase) using monoclonal antibodies.
A role for the high-density lipoprotein receptor SR-B1 in synovial inflammation via serum amyloid-A.
Active matrix metalloproteinase-8 and periodontal bacteria depending on periodontal status in patients with rheumatoid arthritis.
Age at onset of rheumatoid arthritis: association with polymorphisms in the vascular endothelial growth factor A(VEGFA) gene and an intergenic locus between matrix metalloproteinase (MMP) 1 and 3 genes.
Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation.
Andrographolide inhibits the migration, invasion and matrix metalloproteinase expression of rheumatoid arthritis fibroblast-like synoviocytes via inhibition of HIF-1? signaling.
Annexin-1 mediates TNF-alpha-stimulated matrix metalloproteinase secretion from rheumatoid arthritis synovial fibroblasts.
Anti-inflammatory activities of light emitting diode irradiation on collagen-induced arthritis in mice (a secondary publication).
Anti-rheumatic medication and salivary MMP-8, a biomarker for periodontal disease.
Anti-tumour necrosis factor (TNF)-alpha therapy (etanercept) down-regulates serum matrix metalloproteinase (MMP)-3 and MMP-1 in rheumatoid arthritis.
Association of circulating levels of MMP-8 with mortality from respiratory disease in patients with rheumatoid arthritis.
Autocrine induction of gliostatin/platelet-derived endothelial cell growth factor (GLS/PD-ECGF) and GLS-induced expression of matrix metalloproteinases in rheumatoid arthritis synoviocytes.
Bioinformatics analysis reveals different gene expression patterns in the annulus fibrosis and nucleus pulpous during intervertebral disc degeneration.
BRAF splice variants in rheumatoid arthritis synovial fibroblasts activate MAPK through CRAF.
Brain matrix metalloproteinase 1 levels are elevated in Alzheimer's disease.
Cartilage protective agent (CPA) Ro 32-3555, a new matrix metalloproteinase inhibitor for the treatment of rheumatoid arthritis.
CC and CXC chemokine receptors mediate migration, proliferation, and matrix metalloproteinase production by fibroblast-like synoviocytes from rheumatoid arthritis patients.
CD147 induces up-regulation of vascular endothelial growth factor in U937-derived foam cells through PI3K/AKT pathway.
CD147 overexpression on synoviocytes in rheumatoid arthritis enhances matrix metalloproteinase production and invasiveness of synoviocytes.
Correlation among macrophage inflammatory protein 1alpha levels, matrix metalloproteinase 8 levels, and systemic inflammation in rheumatoid arthritis: comment on the articles by Yamanaka et al and Mattey et al.
Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification.
Determination of metalloproteinases, plasminogen-activators and their inhibitors in the synovial fluids of patients with rheumatoid arthritis during chemical synoviorthesis.
Diagnostic utility of anti-cyclic citrullinated peptide antibodies for very early rheumatoid arthritis.
Doxycycline protects serum alpha-1-antitrypsin from human neutrophil collagenase.
Effect of an inhibitor of matrix metalloproteinases on spontaneous osteoarthritis in guinea pigs.
Effects of celecoxib on human chondrocytes--enhanced production of chemokines.
Effects of IL-34 on the secretion of RANKL/OPG by fibroblast-like synoviocytes and peripheral blood mononuclear cells in rheumatoid arthritis.
Enhanced expression of mRNA for nuclear factor kappaB1 (p50) in CD34+ cells of the bone marrow in rheumatoid arthritis.
Expression of CD147 (EMMPRIN) on neutrophils in rheumatoid arthritis enhances chemotaxis, matrix metalloproteinase production and invasiveness of synoviocytes.
Expression of CD147 on monocytes/macrophages in rheumatoid arthritis: its potential role in monocyte accumulation and matrix metalloproteinase production.
Expression of extracellular matrix metalloproteinase inducer and enhancement of the production of matrix metalloproteinases in rheumatoid arthritis.
Expression of matrix metalloproteinase 9 (96-kd gelatinase B) in human rheumatoid arthritis.
Expression of membrane-type matrix metalloproteinases in synovial tissue from patients with rheumatoid arthritis or osteoarthritis.
Expression of the dendritic cell-associated C-type lectin DC-SIGN by inflammatory matrix metalloproteinase-producing macrophages in rheumatoid arthritis synovium and interaction with intercellular adhesion molecule 3-positive T cells.
Gadd45beta deficiency in rheumatoid arthritis: Enhanced synovitis through JNK signaling.
Gingival crevicular fluid MMP-8 and -13 and TIMP-1 levels in patients with rheumatoid arthritis and inflammatory periodontal disease.
Gold sodium thiomalate activates latent human leukocyte collagenase.
Group IB secretory phospholipase A2 promotes matrix metalloproteinase-2-mediated cell migration via the phosphatidylinositol 3-kinase and Akt pathway.
Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy.
Histone Methylation and STAT-3 Differentially Regulate Interleukin-6-Induced Matrix Metalloproteinase Gene Activation in Rheumatoid Arthritis Synovial Fibroblasts.
Hyaluronan inhibits matrix metalloproteinase-13 in human arthritic chondrocytes via CD44 and P38.
Identification of a cytokine-induced repressor of interleukin-1 stimulated expression of stromelysin 1 (MMP-3).
Immunolocalization of MMP-2 and MMP-9 in human rheumatoid synovium.
In vivo model of cartilage degradation--effects of a matrix metalloproteinase inhibitor.
Increased expression of extracellular matrix metalloproteinase inducer in rheumatoid synovium.
Increased expression of Fcgamma receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor alpha and matrix metalloproteinase.
Increased soluble CD4 in serum of rheumatoid arthritis patients is generated by matrix metalloproteinase (MMP)-like proteinases.
Inflammatory biomarkers in saliva and serum of patients with rheumatoid arthritis with respect to periodontal status.
Inhibitory effects of leflunomide therapy on the activity of matrixmetalloproteinase-9 and the release of cartilage oligomeric matrix protein in patients with rheumatoid arthritis.
Knockdown of sphingosine kinase 1 inhibits the migration and invasion of human rheumatoid arthritis fibroblast-like synoviocytes by down-regulating the PI3K/AKT activation and MMP-2/9 production in vitro.
Leflunomide and methotrexate reduce levels of activated matrix metalloproteinases in complexes with alpha2 macroglobulin in serum of rheumatoid arthritis patients.
Ligand-dependent release of active neutrophil collagenase.
Lysis of fibrillar collagen by neutrophils in synovial fluid. A role for surface-bound immunoglobulins.
Macrophage migration inhibitory factor promoter polymorphisms are associated with disease activity in rheumatoid arthritis patients from Southern Mexico.
Matrix metalloproteinase 28/epilysin expression in cartilage from patients with rheumatoid arthritis and osteoarthritis: comment on the article by Kevorkian et al.
Matrix Metalloproteinase Gene Activation Resulting from Disordred Epigenetic Mechanisms in Rheumatoid Arthritis.
Matrix metalloproteinase gene polymorphisms in patients with rheumatoid arthritis.
Matrix metalloproteinase inhibitors in rheumatic diseases.
Matrix metalloproteinase MMP-19 (RASI-1) is expressed on the surface of activated peripheral blood mononuclear cells and is detected as an autoantigen in rheumatoid arthritis.
Matrix metalloproteinase-19 is expressed in myeloid cells in an adhesion-dependent manner and associates with the cell surface.
Matrix metalloproteinase-8 in sera and from polymorphonuclear leucocytes in rheumatoid arthritis: in vitro characterization and correlation with disease activity.
Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells. Regulation by tumor necrosis factor-alpha and doxycycline.
Matrix metalloproteinases-3, -8, -9 as markers of disease activity and joint damage progression in early rheumatoid arthritis.
Mechanical stretch regulates the expression of matrix metalloproteinase in rheumatoid arthritis fibroblast-like synoviocytes.
Messenger-RNA expression of matrix metalloproteinases, tissue inhibitors of metalloproteinases, and transcription factors in rheumatic synovial cells under mechanical stimuli.
MMP-8 and TIMP-1 are associated to periodontal inflammation in patients with rheumatoid arthritis under methotrexate immunosuppression - First results of a cross-sectional study.
Modulation of matrix metalloproteinase production by rheumatoid arthritis synovial fibroblasts after cadherin 11 engagement.
Molecular mechanism of transcriptional activation of human gelatinase B by proximal promoter.
Polymorphisms of MMP-1 and MMP-3 and susceptibility to rheumatoid arthritis. A meta-analysis.
Prevention of progressive joint destruction in adjuvant induced arthritis in rats by a novel matrix metalloproteinase inhibitor, FR217840.
Promoter competition assay for analyzing gene regulation in joint tissue engineering.
Prostaglandin E2 differentially modulates proinflammatory/prodestructive effects of TNF-alpha on synovial fibroblasts via specific E prostanoid receptors/cAMP.
Proteases as drug targets.
Protective Effect of Withania somnifera and Cardiospermum halicacabum Extracts Against Collagenolytic Degradation of Collagen.
Protein isoprenylation regulates secretion of matrix metalloproteinase 1 from rheumatoid synovial fibroblasts: effects of statins and farnesyl and geranylgeranyl transferase inhibitors.
Pyrrolidine dithiocarbamate, a NF-kappaB inhibitor, upregulates MMP-1 and MMP-13 in IL-1beta-stimulated rheumatoid arthritis fibroblast-like synoviocytes.
Reduced chemokine and matrix metalloproteinase expression in patients with rheumatoid arthritis achieving remission.
Reduction of interleukin-1? induced matrix metalloproteinase-3 release by extracts of six plants: inhibitory screening of 35 traditional medicinal plants.
Reduction of serum matrix metalloproteinase 1 and matrix metalloproteinase 3 in rheumatoid arthritis patients following anti-tumour necrosis factor-alpha (cA2) therapy.
Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c-Jun N-Terminal kinase pathway.
Regulation of JNK by MKK-7 in fibroblast-like synoviocytes.
Relationship between matrix metalloproteinase-3 serum level and pulmonary artery systolic pressure in patients with rheumatoid arthritis.
S100A4 is expressed at site of invasion in rheumatoid arthritis synovium and modulates production of matrix metalloproteinases.
Serum insulin-like growth factor-axis and matrix metalloproteinases in patients with rheumatic arthritis or rheumatic heart disease.
Serum Levels of Matrix Metalloproteinase (MMP) 9, a Risk Factor for Acute Coronary Syndrome, Are Reduced Independently of Serum MMP-3 by Anti-TNF-? Antibody (Infliximab) Therapy in Patients With Rheumatoid Arthritis.
Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice.
Synovial IL-21/TNF-producing CD4(+) T cells induce joint destruction in rheumatoid arthritis by inducing matrix metalloproteinase production by fibroblast-like synoviocytes.
Synoviocyte innate immune responses: I. Differential regulation of interferon responses and the JNK pathway by MAPK kinases.
Targeted knockout of TNF-? by injection of lentivirus-mediated siRNA into the subacromial bursa for the treatment of subacromial bursitis in rats.
The effects of periodontal therapy on gingival crevicular fluid matrix metalloproteinase-8, interleukin-6 and prostaglandin E2 levels in patients with rheumatoid arthritis.
The effects of pulse methylprednisolone on matrix metalloproteinase and tissue inhibitor of metalloproteinase-1 expression in rheumatoid arthritis.
The matrix metalloproteinase RASI-1 is expressed in synovial blood vessels of a rheumatoid arthritis patient.
The oral administration effect of drug mannuronic acid (M2000) on gene expression of matrix and tissue inhibitor of metalloproteinases in rheumatoid arthritis patients.
Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors.
Treating to target matrix metalloproteinase 3 normalisation together with disease activity score below 2.6 yields better effects than each alone in rheumatoid arthritis patients: T-4 Study.
Tumor necrosis factor receptor-associated factor 6 (TRAF6) inhibition modulates bone loss and matrix metalloproteinase expression levels in collagen-induced rheumatoid arthritis rat.
[Application of NFkappaB inhibitor for arthritis]
[Correlations between serum matrix metalloproteinase (MMP-1, MMP-3, MMP-9, MMP-13) concentrations and markers of disease activity in early rheumatoid arthritis]
[Dynamics of matrix metalloproteinase (MMP)-13 in the patients with rheumatoid arthritis]
[Matrix metalloproteinase (MMP-9) in patients with rheumatoid arthritis]
[Matrix metalloproteinase 2, 3, and 9 gene polymorphisms in women with rheumatoid arthritis].
[Polymorphism of gene promotor region for MMP-2 in rheumatoid arthritis]
Aspergillosis
Cytoskeletal Alteration Is an Early Cellular Response in Pulmonary Epithelium Infected with Aspergillus fumigatus Rather than Scedosporium apiospermum.
Asthma
A murine model of toluene diisocyanate-induced asthma can be treated with matrix metalloproteinase inhibitor.
Airway obstruction correlates with collagenase-2 (MMP-8) expression and activation in bronchial asthma.
An extract of Crataegus pinnatifida fruit attenuates airway inflammation by modulation of matrix metalloproteinase-9 in ovalbumin induced asthma.
Association of matrix metalloproteinase 8 genetic polymorphisms with bronchial asthma in a Japanese population.
Children with stable asthma have reduced airway matrix metalloproteinase-9 and matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio.
Contribution of 92 kDa gelatinase/type IV collagenase in bronchial inflammation during status asthmaticus.
Corelationship between matrix metalloproteinase 2 and 9 expression and severity of chronic rhinosinusitis with nasal polyposis.
Detection and monitoring of localized matrix metalloproteinase upregulation in a murine model of asthma.
Effect of selective cysteinyl leukotriene receptor antagonists on airway inflammation and matrix metalloproteinase expression in a mouse asthma model.
Effect of Xiaochuanping powder on the inflammatory response and airway remodeling in asthmatic rats.
Effects of Inhaled Corticosteroids on Metalloproteinase-8 and Tissue Inhibitor of Metalloproteinase-1 in the Airways of Asthmatic Children.
Expression of matrix metalloproteinases MMP-9 within the airways in asthma.
Human Rhinovirus Infection Upregulates MMP-9 Production in Airway Epithelial Cells via NF-{kappa}B.
Immune responses of airway neutrophils are impaired in asthma.
Immunohistochemical localisation of the matrix metalloproteinases MMP-3 and MMP-9 within the airways in asthma.
Increased angiogenic factors in exhaled breath condensate of children with severe asthma - New markers of disease progression?
Increased circulating 92 kDa matrix metalloproteinase (MMP-9) activity in exacerbations of asthma.
Increased serum concentrations of tissue inhibitor of metalloproteinase-1 in COPD patients.
Inhaled corticosteroids do not reduce initial high activity of matrix metalloproteinase (MMP)-9 in exhaled breath condensates of children with asthma exacerbation: a proof of concept study.
Localization of Matrix Metalloproteinase (MMP)-9 in Lung Tissue of a Murine Model of Allergic Asthma.
Low sputum MMP-9/TIMP ratio is associated with airway narrowing in smokers with asthma.
Matrix metalloproteinase inhibitor regulates inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression in a murine model of toluene diisocyanate-induced asthma.
Matrix metalloproteinase-1 polymorphism is associated with persistent airway obstruction in asthma in the Taiwanese population.
Matrix metalloproteinase-12 is a therapeutic target for asthma in children and young adults.
Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation.
Matrix metalloproteinase-9 deficiency impairs cellular infiltration and bronchial hyperresponsiveness during allergen-induced airway inflammation.
Matrix metalloproteinase-9 in lung remodeling.
Mechanical stress is communicated between different cell types to elicit matrix remodeling.
Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3-like protein 1.
Neovastat (AE-941) inhibits the airway inflammation and hyperresponsiveness in a murine model of asthma.
Neutrophil-derived matrix metalloproteinase-9 is increased in severe asthma and poorly inhibited by glucocorticoids.
Polymorphic Variants 279R and 668Q Augment Activity of Matrix Metalloproteinase-9 in Breath Condensates of Children with Asthma.
Prolonged Treatment with Inhaled Corticosteroids does not Normalize High Activity of Matrix Metalloproteinase-9 in Exhaled Breath Condensates of Children with Asthma.
Proteomics: is it an approach to understand the progression of chronic lung disorders?
Salmeterol or doxycycline do not inhibit acute bronchospasm and airway inflammation in cats with experimentally-induced asthma.
Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: Relationship to disease severity.
Sulphonamides: Deserving class as MMP inhibitors?
The effect of marimastat, a metalloprotease inhibitor, on allergen-induced asthmatic hyper-reactivity.
The effects of interleukin-33 on airways collagen deposition and matrix metalloproteinase expression in a murine surrogate of asthma.
Thioredoxin fusion construct enables high-yield production of soluble, active matrix metalloproteinase-8 (MMP-8) in Escherichia coli.
Use of a three dimensional cell culture model to study airway smooth muscle / mast cell interactions in airway remodelling.
Zingiber cassumunar ROXb. and its active constituent inhibit MMP-9 direct activation by house dust mite allergens and MMP-9 expression in PMA-stimulated human airway epithelial cells.
Astrocytoma
Activated leukocyte cell adhesion molecule is expressed in neuroepithelial neoplasms and decreases with tumor malignancy, matrix metalloproteinase 2 expression, and absence of IDH1R132H mutation.
Curcumin is a potent broad spectrum inhibitor of matrix metalloproteinase gene expression in human astroglioma cells.
Exogenous C2 Ceramide Suppresses Matrix Metalloproteinase Gene Expression by Inhibiting ROS Production and MAPK Signaling Pathways in PMA-Stimulated Human Astroglioma Cells.
Matrix metalloproteinase expression in childhood astrocytomas.
Repression of matrix metalloproteinase gene expression by ginsenoside Rh2 in human astroglioma cells.
Specific matrix metalloproteinase profiles in the cerebrospinal fluid correlated with the presence of malignant astrocytomas, brain metastases, and carcinomatous meningitis.
Targeting hyaluronan interactions in spinal cord astrocytomas and diffuse pontine gliomas.
Ataxia Telangiectasia
Simian virus 40 transformation alters the actin cytoskeleton, expression of matrix metalloproteinases and inhibitors of metalloproteinases, and invasive behavior of normal and ataxia-telangiectasia human skin fibroblasts.
Atherosclerosis
A fluorescence lifetime spectroscopy study of matrix metalloproteinases-2 and -9 in human atherosclerotic plaque.
A Role of Matrix Metalloproteinase-8 in Atherosclerosis.
Aging increases aortic MMP-2 activity and angiotensin II in nonhuman primates.
Alcohol reduces MMP-2 in humans and isolated smooth muscle cells.
Allele-specific regulation of matrix metalloproteinase-12 gene activity is associated with coronary artery luminal dimensions in diabetic patients with manifest coronary artery disease.
An Important Role of Matrix Metalloproteinase-8 in Angiogenesis in Vitro and in Vivo.
Angiotensin-(1-7) regulates angiotensin II-induced matrix metalloproteinase-8 in vascular smooth muscle cells.
Association of the matrix metalloproteinase-3 (-439C/G) promoter polymorphism with Kawasaki disease in Korean children.
Associations between serum relaxin 2, aneurysm formation/size and severity of atherosclerosis: a preliminary prospective analysis.
Atherosclerosis plaque heterogeneity and response to therapy detected by in vivo molecular imaging of matrix metalloproteinase activation.
Atherosclerotic plaque vulnerability is increased in mouse model of lupus.
Atorvastatin attenuates plaque vulnerability by downregulation of EMMPRIN expression via COX-2/PGE2 pathway.
C-reactive protein induces matrix metalloproteinase-1 and -10 in human endothelial cells: implications for clinical and subclinical atherosclerosis.
Can matrix metalloproteinase inhibitors provide a realistic therapy in cardiovascular medicine?
Carnosic acid prevents the migration of human aortic smooth muscle cells by inhibiting the activation and expression of matrix metalloproteinase-9.
Carvedilol, a pharmacological antioxidant, inhibits neointimal matrix metalloproteinase-2 and -9 in experimental atherosclerosis.
Characterization of plaques using 18F-FDG PET/CT in patients with carotid atherosclerosis and correlation with matrix metalloproteinase-1.
Cocoa procyanidins inhibit expression and activation of MMP-2 in vascular smooth muscle cells by direct inhibition of MEK and MT1-MMP activities.
Cordycepin inhibits vascular smooth muscle cell proliferation.
Corilagin ameliorates atherosclerosis by regulating MMP-1, -2, and -9 expression in vitro and in vivo.
Crystal structure of full-length human collagenase 3 (MMP-13) with peptides in the active site defines exosites in the catalytic domain.
Dietary flax seed in prevention of hypercholesterolemic atherosclerosis.
Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms.
Discovery of Sulfated Small Molecule Inhibitors of Matrix Metalloproteinase-8.
Dual molecular imaging for targeting metalloproteinase activity and apoptosis in atherosclerosis: molecular imaging facilitates understanding of pathogenesis.
Effect of matrix metalloproteinase inhibition on progression of atherosclerosis and aneurysm in LDL receptor-deficient mice overexpressing MMP-3, MMP-12, and MMP-13 and on restenosis in rats after balloon injury.
Effects of matrix metalloproteinase 13 on vascular smooth muscle cells migration via Akt-ERK dependent pathway.
Elevated MMP-8 and decreased myeloperoxidase concentrations associate significantly with the risk for peripheral atherosclerosis disease and abdominal aortic aneurysm.
Enzymatic modification of low-density lipoprotein in the arterial wall: a new role for plasmin and matrix metalloproteinases in atherogenesis.
Expression of neutrophil gelatinase-associated lipocalin in atherosclerosis and myocardial infarction.
Expression of stromelysin-3 in atherosclerotic lesions: regulation via CD40-CD40 ligand signaling in vitro and in vivo.
Familial abdominal aortic aneurysm: a systematic review of a genetic background.
Family history of hypertension, anthropometric parameters and markers of early atherosclerosis in young healthy individuals.
Functional polymorphism in the regulatory region of gelatinase B gene in relation to severity of coronary atherosclerosis.
Genetics of ultrasonographic carotid atherosclerosis.
Genistein inhibits Ang II-induced CRP and MMP-9 generations via the ER-p38/ERK1/2-PPAR?-NF-?B signaling pathway in rat vascular smooth muscle cells.
Ghrelin inhibits atherosclerotic plaque angiogenesis and promotes plaque stability in a rabbit atherosclerotic model.
Ham-Wasserman lecture: role of the plasminogen system in fibrin-homeostasis and tissue remodeling.
Heparin inhibits the production of matrix metalloproteinase-2 and improves atherosclerosis in LDL receptor-deficient mice.
High glucose alters matrix metalloproteinase expression in two key vascular cells: potential impact on atherosclerosis in diabetes.
High serum level of matrix metalloproteinase-1 and its rapid surge after intervention in patients with significant carotid atherosclerosis.
Hydrolysis of triple-helical collagen peptide models by matrix metalloproteinases.
Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo.
Inhibition of endogenous nitric oxide in the heart enhances matrix metalloproteinase-2 release.
Inhibitory effect of Uncaria sinensis on human aortic smooth muscle cell migration is based on matrix metalloproteinase-9 inhibitory activity.
Interleukin-10 protects against atherosclerosis by modulating multiple atherogenic macrophage function.
Intracoronary upregulation of platelet extracellular matrix metalloproteinase inducer (CD147) in coronary disease.
Investigation of RNA interference suppression of matrix metalloproteinase-9 in mouse model of atherosclerosis.
Involvement of integrins, MAPK, and NF-kappaB in regulation of the shear stress-induced MMP-9 expression in endothelial cells.
Involvement of TL1A and DR3 in induction of pro-inflammatory cytokines and matrix metalloproteinase-9 in atherogenesis.
Lithium chloride suppresses LPS-mediated matrix metalloproteinase-9 expression in macrophages through phosphorylation of GSK-3?.
Loss of matrix metalloproteinase-9 or matrix metalloproteinase-12 protects apolipoprotein E-deficient mice against atherosclerotic media destruction but differentially affects plaque growth.
Macrophage-derived MMP-8 determines smooth muscle cell differentiation from adventitia stem/progenitor cells and promotes neointima hyperplasia.
Macrophage-mediated proteolytic remodeling of the extracellular matrix in atherosclerosis results in neoepitopes: a potential new class of biochemical markers.
Mast cells promote atherosclerosis by releasing proinflammatory cytokines.
Matrix metalloproteinase inhibition in atherosclerosis and stroke.
Matrix metalloproteinase: investigation from gene to protein as effective factor in myocardial infarction.
Matrix-metalloproteinase-14 deficiency in bone-marrow-derived cells promotes collagen accumulation in mouse atherosclerotic plaques.
Mechanisms of aortic valve calcification.
Mice deficient in PKCbeta and apolipoprotein E display decreased atherosclerosis.
MicroRNA-21 is a unique signature associated with coronary plaque instability in humans by regulating matrix metalloproteinase-9 via reversion-inducing cysteine-rich protein with Kazal motifs.
MMP-9 inhibition by ACE inhibitor reduces oxidized LDL-mediated foam-cell formation.
Molecular imaging of matrix metalloproteinase in atherosclerotic lesions: resolution with dietary modification and statin therapy.
Non-Invasive Detection of Extracellular Matrix Metalloproteinase Inducer EMMPRIN, a New Therapeutic Target against Atherosclerosis, Inhibited by Endothelial Nitric Oxide.
Novel Potent Proline-Based Metalloproteinase Inhibitors: Design, (Radio)Synthesis, and First in Vivo Evaluation as Radiotracers for Positron Emission Tomography.
Overexpression of MMP-9 and its inhibitors in blood mononuclear cells after myocardial infarction--is it associated with depressive symptomatology?
Pimaric acid from Aralia cordata has an inhibitory effect on TNF-?-induced MMP-9 production and HASMC migration via down-regulated NF-?B and AP-1.
Pivotal role of serum- and glucocorticoid-inducible kinase 1 in vascular inflammation and atherogenesis.
Possible Mechanisms of Di(2-ethylhexyl) Phthalate-Induced MMP-2 and MMP-9 Expression in A7r5 Rat Vascular Smooth Muscle Cells.
Potential implications of matrix metalloproteinase-9 in assessment and treatment of coronary artery disease.
Potential role of proteasome on c-jun related signaling in hypercholesterolemia induced atherosclerosis.
Practical implications of novel serum ELISA-assay for matrix metalloproteinase-8 in acute cardiac diagnostics.
Probes for non-invasive matrix metalloproteinase-targeted imaging with PET and SPECT.
Proprotein convertase subtilisin/kexin type 3 promotes adipose tissue-driven macrophage chemotaxis and is increased in obesity.
Putative targeting of matrix metalloproteinase-8 in atherosclerosis.
RANK/RANKL/OPG pathway: genetic association with history of ischemic stroke in Italian population.
Reduction of mouse atherosclerosis by urokinase inhibition or with a limited-spectrum matrix metalloproteinase inhibitor.
Reductions of circulating matrix metalloproteinase 2 and vascular endothelial growth factor levels after treatment with pegvisomant in subjects with acromegaly.
Role of matrix metalloproteinase-8 in atherosclerosis.
Serum matrix metalloproteinase-8 concentrations are associated with cardiovascular outcome in men.
Synthesis and evaluation of a novel fluorescent photoprobe for imaging matrix metalloproteinases.
Synthesis and preliminary biological evaluation of new radioiodinated MMP inhibitors for imaging MMP activity in vivo.
The feedback loop of "EMMPRIN/NF-?B" worsens atherosclerotic plaque via suppressing autophagy in macrophage.
Therapeutic potential of matrix metalloproteinase inhibitors in atherosclerosis.
Thrombin-thrombomodulin activation of protein C facilitates the activation of progelatinase A.
Tissue inhibitor of matrix metalloproteinase-3 levels in the extracellular matrix of lung, kidney, and eye increase with age.
Translating Koch's postulates to identify matrix metalloproteinase roles in postmyocardial infarction remodeling: cardiac metalloproteinase actions (CarMA) postulates.
Treatment with simvastatin suppresses the development of experimental abdominal aortic aneurysms in normal and hypercholesterolemic mice.
Upregulation of extracellular matrix metalloproteinase inducer (EMMPRIN) and gelatinases in human atherosclerosis infected with Chlamydia pneumoniae: the potential role of Chlamydia pneumoniae infection in the progression of atherosclerosis.
Use of Edman degradation sequence analysis and matrix-assisted laser desorption/ionization mass spectrometry in designing substrates for matrix metalloproteinases.
[Analysis of the gene polymorphism of matrix metalloproteinase-2 and -9 in patients with coronary heart disease]
[Effect of Dracocephalum moldavica total flavones on expression of TGF-?1/Smad signaling pathway and matrix metalloproteinase of atherosclerosis ApoE-/- mice].
[Influence of periodontal therapy on serum interleukin-6 and carotid metalloproteinases in animals with chronic periodontitis associated with atherosclerosis].
[Measurement peripheral blood index related to inflammation and ox-LDL, ox-LDLAb in patients with coronary heart disease and its clinical significance]
[Role of anti-angiogenic factor chondromodulin-I for maintaining cardiac valvular function]
Atrial Fibrillation
Accelerated fibrosis and apoptosis with ageing and in atrial fibrillation: Adaptive responses with maladaptive consequences.
Changes in matrix metalloproteinase-9 levels during progression of atrial fibrillation.
Matrix metalloproteinase inhibition attenuates atrial remodeling and vulnerability to atrial fibrillation in a canine model of heart failure.
Matrix Metalloproteinase Neutrophil Gelatinase-Associated Lipocalin Complex Predicts Atrial Fibrillation Recurrence after Electrical Cardioversion in Obese Patients.
MMP9 Rs3918242 Polymorphism Affects Tachycardia-Induced MMP9 Expression in Cultured Atrial-Derived Myocytes but Is Not a Risk Factor for Atrial Fibrillation among the Taiwanese.
Perspectives on the value of biomarkers in acute cardiac care and implications for strategic management.
[Metalloproteinase activity of the blood in patients with arterial hypertension with paroxysmal form of atrial fibrillation.]
[Role of matrix metalloproteinase and tissue inhibitor of metalloproteinase in atrial structural remodeling in patients with atrial fibrillation]
Autoimmune Diseases
A novel rationale for inhibition of gelatinase B in multiple sclerosis: MMP-9 destroys alpha B-crystallin and generates a promiscuous T cell epitope.
Matrix metalloproteinase and G protein coupled receptors: Co-conspirators in the pathogenesis of autoimmune disease and cancer.
Tear Matrix Metalloproteinases and Myeloperoxidase Levels in Patients With Boston Keratoprosthesis Type I.
Axial Spondyloarthritis
Is radiographic progression in radiographic axial spondyloarthritis related to matrix metalloproteinase degradation of extracellular matrix?
Bacteremia
Matrix metalloproteinase MMP-8, TIMP-1 and MMP-8/TIMP-1 ratio in plasma in methicillin-sensitive Staphylococcus aureus bacteremia.
Potential Co-Relation Between Chronic Periodontitis And Cancer - An Emerging Concept.
Bacterial Infections
Genetic susceptibility to total hip arthroplasty failure: a preliminary study on the influence of matrix metalloproteinase 1, interleukin 6 polymorphisms and vitamin D receptor.
Pre-exposure to high glucose augments lipopolysaccharide-stimulated matrix metalloproteinase-1 expression by human U937 histiocytes.
Barrett Esophagus
Matrix metalloproteinase (MMP)-7 in Barrett's esophagus and esophageal adenocarcinoma: expression, metabolism, and functional significance.
beta-Thalassemia
Association of thalassemia major and gingival inflammation: A pilot study.
Bicuspid Aortic Valve Disease
Circulating matrix metalloproteinase patterns in association with aortic dilatation in bicuspid aortic valve patients with isolated severe aortic stenosis.
Enlarged Size and Impaired Elastic Properties of the Ascending Aorta are Associated with Endothelial Dysfunction and Elevated Plasma Matrix Metalloproteinase-2 Level in Patients with Bicuspid Aortic Valve.
Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valves.
Vascular matrix remodeling in patients with bicuspid aortic valve malformations: implications for aortic dilatation.
Blister
A case of anaphylactoid purpura with multiple blister formation: possible pathophysiological role of gelatinase (MMP-9).
A sequential, multiple-treatment, targeted approach to reduce wound healing and failure of glaucoma filtration surgery in a rabbit model (an American Ophthalmological Society thesis).
Effect of smoking, abstention, and nicotine patch on epidermal healing and collagenase in skin transudate.
Matrix metalloproteinase gelatinase B (MMP-9) is associated with leaking glaucoma filtering blebs.
Respective contribution of neutrophil elastase and matrix metalloproteinase 9 in the degradation of BP180 (type XVII collagen) in human bullous pemphigoid.
Sequential Therapy with Saratin, Bevacizumab and Ilomastat to Prolong Bleb Function following Glaucoma Filtration Surgery in a Rabbit Model.
Smoking affects collagen synthesis and extracellular matrix turnover in human skin.
Bone Cysts
TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NF-kappaB.
Bone Diseases
Matrix Metalloproteinase Inspired Therapeutic Strategies for Bone Diseases.
Metastatic bone disease: pathogenesis and new strategies for treatment.
Simvastatin, an HMG-CoA reductase inhibitor, reduced the expression of matrix metalloproteinase-9 (Gelatinase B) in osteoblastic cells and HT1080 fibrosarcoma cells.
Bone Resorption
A combination of a chemically modified doxycycline and a bisphosphonate synergistically inhibits endotoxin-induced periodontal breakdown in rats.
A critical role for suppressors of cytokine signaling 3 in regulating LPS-induced transcriptional activation of matrix metalloproteinase-13 in osteoblasts.
A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis.
Association of gingival crevicular fluid biomarkers during periodontal maintenance with subsequent progressive periodontitis.
Chemerin Treatment Inhibits the Growth and Bone Invasion of Breast Cancer Cells.
Detection of gelatinase B expression reveals osteoclastic bone resorption as a feature of early calvarial bone development.
Effect of local hIL-10 gene therapy on experimental periodontitis in ovariectomized rats.
Effects of matrix metalloproteinase inhibitors on bone resorption and orthodontic tooth movement.
Expression of MMP-8 and MMP-13 in the development of periradicular lesions.
Gene expression analyses in malformed skeletal structures of gilthead sea bream (Sparus aurata).
In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition: relationship to bone and cartilage degradation.
Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bisphosphonate ibandronate and tissue inhibitor of the matrix metalloproteinase-2.
Localisation of mRNA for collagenase in osteocytic, bone surface and chondrocytic cells but not osteoclasts.
miR-506-3p alleviates uncontrolled osteoclastogenesis via repression of RANKL/NFATc1 signaling pathway.
Phase I and pharmacological study of the oral matrix metalloproteinase inhibitor, MMI270 (CGS27023A), in patients with advanced solid cancer.
Relevance of an in vitro osteoclastogenesis system to study receptor activator of NF-kB ligand and osteoprotegerin biological activities.
T cells stimulate catabolic gene expression by the stromal cells from giant cell tumor of bone.
The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction.
The effects of selective inhibitors of matrix metalloproteinases (MMPs) on bone resorption and the identification of MMPs and TIMP-1 in isolated osteoclasts.
The influence of type 2 diabetes mellitus on the expression of inflammatory mediators and tissue inhibitor of metalloproteinases-2 in human chronic periodontitis.
The migration of purified osteoclasts through collagen is inhibited by matrix metalloproteinase inhibitors.
The relative contribution of cysteine proteinases and matrix metalloproteinases to the resorption process in osteoclasts derived from long bone and scapula.
Transforming growth factor-beta controls human osteoclastogenesis through the p38 MAPK and regulation of RANK expression.
Tumor necrosis factor-alpha and its receptors, p55 and p75, in gingiva of adult periodontitis.
[Bone and bone related biochemical examinations. Bone and collagen related metabolites. Urinary and serum NTX as bone resorption markers]
Brain Diseases
Lipopolysaccharide-Induced Matrix Metalloproteinase-9 Expression Associated with Cell Migration in Rat Brain Astrocytes.
Brain Edema
Basic Fibroblast Growth Factor (bFGF) Protects the Blood-Brain Barrier by Binding of FGFR1 and Activating the ERK Signaling Pathway After Intra-Abdominal Hypertension and Traumatic Brain Injury.
Brain pericytes are the most thrombin-sensitive matrix metalloproteinase-9-releasing cell type constituting the blood-brain barrier in vitro.
Contribution of matrix metalloproteinase-9 to cerebral edema and functional outcome following experimental subarachnoid hemorrhage.
Delayed matrix metalloproteinase inhibition reduces intracerebral hemorrhage after embolic stroke in rats.
Early VEGF inhibition attenuates blood-brain barrier disruption in ischemic rat brains by regulating the expression of MMPs.
Galangin Inhibits Thrombin-Induced MMP-9 Expression in SK-N-SH Cells via Protein Kinase-Dependent NF-?B Phosphorylation.
Matrix metalloproteinase inhibition attenuates brain edema after surgical brain injury.
MATRIX METALLOPROTEINASE INHIBITION ATTENUATES BRAIN EDEMA IN AN IN VIVO MODEL OF SURGICALLY-INDUCED BRAIN INJURY.
Matrix metalloproteinase inhibition attenuates brain edema in an in vivo model of surgically-induced brain injury.
MATRIX METALLOPROTEINASE INHIBITION ATTENUATES BRAIN EDEMA IN AN IN VIVO MODEL OF SURGICALLY-INDUCED BRAIN INJURY.
Memantine protects blood-brain barrier integrity and attenuates neurological deficits through inhibiting nitric oxide synthase ser1412 phosphorylation in intracerebral hemorrhage rats: involvement of peroxynitrite-related matrix metalloproteinase-9/NLRP3 inflammasome activation.
Mito-Tempo prevents nicotine-induced exacerbation of ischemic brain damage.
Monoacylglycerol Lipase Inhibitor is Safe when Combined with Delayed r-tPA Administration in Treatment of Stroke.
Progesterone attenuates early brain injury after subarachnoid hemorrhage in rats.
Reduced brain edema and matrix metalloproteinase (MMP) expression by pre-reperfusion infusion into ischemic territory in rat.
Selective MMP-inhibition with Ro 28-2653 in acute experimental stroke - a magnetic resonance imaging efficacy study.
Simvastatin in traumatic brain injury: Effect on brain edema mechanisms.
TIMP-1/MMP-9 imbalance in brain edema in rats with fulminant hepatic failure.
Treatment of cold injury-induced brain edema with a nonspecific matrix metalloproteinase inhibitor MMI270 in rats.
Tumor necrosis factor-alpha neutralization reduced cerebral edema through inhibition of matrix metalloproteinase production after transient focal cerebral ischemia.
Brain Injuries
A Prospective Evaluation of the Temporal Matrix Metalloproteinase Response after Severe Traumatic Brain Injury in Humans.
Cerebroprotection by the neuronal PGE2 receptor EP2 after intracerebral hemorrhage in middle-aged mice.
Combined therapy with ceftriaxone and doxycycline does not improve the outcome of meningococcal meningitis in mice compared to ceftriaxone monotherapy.
Delayed administration of a matrix metalloproteinase inhibitor limits progressive brain injury after hypoxia-ischemia in the neonatal rat.
Flavonoids targeting of I?B phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells.
Inhibition of matrix metalloproteinases-2/-9 transiently reduces pre-oligodendrocyte loss during lipopolysaccharide- but not tumour necrosis factor-alpha-induced inflammation in fetal ovine glial culture.
Matrix metalloproteinase inhibition attenuates brain edema after surgical brain injury.
MATRIX METALLOPROTEINASE INHIBITION ATTENUATES BRAIN EDEMA IN AN IN VIVO MODEL OF SURGICALLY-INDUCED BRAIN INJURY.
Matrix metalloproteinase inhibition attenuates brain edema in an in vivo model of surgically-induced brain injury.
MATRIX METALLOPROTEINASE INHIBITION ATTENUATES BRAIN EDEMA IN AN IN VIVO MODEL OF SURGICALLY-INDUCED BRAIN INJURY.
Matrix metalloproteinase inhibition lowers mortality and brain injury in experimental pneumococcal meningitis.
Matrix metalloproteinase-9 contributes to brain extravasation and edema in fulminant hepatic failure mice.
Neuroprotection by inhibition of matrix metalloproteinases in a mouse model of intracerebral haemorrhage.
Serum matrix metalloproteinase levels correlate with brain injury in human immunodeficiency virus infection.
Targeting RNS/caveolin-1/MMP signaling cascades to protect against cerebral ischemia-reperfusion injuries: potential application for drug discovery.
The matrix metalloproteinase inhibitor RS-130830 attenuates brain injury in experimental pneumococcal meningitis.
[Expression of matrix metalloproteinase MMP-9 in the plasma and hematoma fluid of intracerebral hemorrhage patients]
Brain Injuries, Traumatic
A Prospective Evaluation of the Temporal Matrix Metalloproteinase Response after Severe Traumatic Brain Injury in Humans.
Association between the Cerebral Inflammatory and Matrix Metalloproteinase Responses after Severe Traumatic Brain Injury in Humans.
Blood-brain barrier dysfunction significantly correlates with serum matrix metalloproteinase-7 (MMP-7) following traumatic brain injury.
Influence of therapeutic hypothermia on matrix metalloproteinase activity after traumatic brain injury in rats.
Matrix Metalloproteinase Expression in Contusional Traumatic Brain Injury: A Paired Microdialysis Study.
Prognostic utility of early plasma matrix metalloproteinases -2 and -9 concentrations after severe traumatic brain injury.
Quantitative analyses of matrix metalloproteinase activity after traumatic brain injury in adult rats.
Water-Soluble MMP-9 Inhibitor Reduces Lesion Volume after Severe Traumatic Brain Injury.
Brain Ischemia
A gelatin in situ-overlay technique localizes brain matrix metalloproteinase activity in experimental focal cerebral ischemia.
An in-silico strategy to explore neuroprotection by quercetin in cerebral ischemia: a novel hypothesis based on inhibition of matrix metalloproteinase (MMPs) and acid sensing ion channel 1a (ASIC1a).
Analysis of regulatory effect of miR-149-5p on Sphingosine-1-phosphate receptor 2 of pericytes and its neuroprotective molecular mechanism after acute cerebral ischemia reperfusion in rats.
Blockade of Apoptosis Signal-Regulating Kinase 1 Attenuates Matrix Metalloproteinase 9 Activity in Brain Endothelial Cells and the Subsequent Apoptosis in Neurons after Ischemic Injury.
Closure of the blood-brain barrier by matrix metalloproteinase inhibition reduces rtPA-mediated mortality in cerebral ischemia with delayed reperfusion.
Comparison of matrix metalloproteinase activation after focal cortical ischemia in young adult and aged mice.
Crocin protects against cerebral- ischemia-induced damage in aged rats through maintaining the integrity of blood-brain barrier.
Doxycycline inhibits matrix metalloproteinase-9 and laminin degradation after transient global cerebral ischemia.
Fluorometric immunocapture assay for the specific measurement of matrix metalloproteinase-9 activity in biological samples: application to brain and plasma from rats with ischemic stroke.
Genetic Deletion or Pharmacological Inhibition of Cyclooxygenase-2 Reduces Blood-Brain Barrier Damage in Experimental Ischemic Stroke.
In Vivo Evidence that the Increase in Matrix Metalloproteinase Activity Occurs Early after Cerebral Ischemia.
In vivo near-infrared fluorescence imaging of matrix metalloproteinase activity after cerebral ischemia.
Increased intranuclear matrix metalloproteinase activity in neurons interferes with oxidative DNA repair in focal cerebral ischemia.
Lithium chloride suppresses LPS-mediated matrix metalloproteinase-9 expression in macrophages through phosphorylation of GSK-3?.
Matrix metalloproteinase expression is related to hemorrhagic transformation after cardioembolic stroke.
Matrix metalloproteinase induction by EMMPRIN in experimental focal cerebral ischemia.
Matrix metalloproteinase inhibition prevents oxidative stress-associated blood-brain barrier disruption after transient focal cerebral ischemia.
Matrix metalloproteinase inhibitor KB-R7785 attenuates brain damage resulting from permanent focal cerebral ischemia in mice.
Matrix metalloproteinase inhibitors attenuate neuroinflammation following focal cerebral ischemia in mice.
Matrix Metalloproteinase-8 is a Novel Pathogenetic Factor in Focal Cerebral Ischemia.
Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke.
Neuroprotective effects of N-acetylcysteine via inhibition of matrix metalloproteinase in a mouse model of transient global cerebral ischemia.
Peroxynitrite decomposition catalyst prevents matrix metalloproteinase activation and neurovascular injury after prolonged cerebral ischemia in rats.
PPARgamma agonist pioglitazone rescues neuronal cell damage after transient global cerebral ischemia through matrix metalloproteinase inhibition.
Quercetin reduces the elevated matrix metalloproteinases-9 level and improves functional outcome after cerebral focal ischemia in rats.
The expression of matrix metalloproteinase-13 is increased in vessels with blood-brain barrier impairment in a stroke-prone hypertensive model.
The neuroprotective effect of MicroRNA-149-5p and coenzymeQ10 by reducing levels of inflammatory cytokines and metalloproteinases following focal brain ischemia in rats.
Tumor necrosis factor-alpha neutralization reduced cerebral edema through inhibition of matrix metalloproteinase production after transient focal cerebral ischemia.
Brain Neoplasms
Concanavalin-A-induced autophagy biomarkers requires membrane type-1 matrix metalloproteinase intracellular signaling in glioblastoma cells.
Direct activation of pro-matrix metalloproteinase-2 by leukolysin/membrane-type 6 matrix metalloproteinase/matrix metalloproteinase 25 at the asn(109)-Tyr bond.
Elevated levels of Mr 92,000 type IV collagenase during tumor growth in vivo.
Evaluation of the effects of swainsonine, captopril, tangeretin and nobiletin on the biological behaviour of brain tumour cells in vitro.
Evidence of MTCBP-1 interaction with the cytoplasmic domain of MT1-MMP: Implications in the autophagy cell index of high-grade glioblastoma.
Expression of MMP-2, MMP-7, MMP-9, MMP-10 and MMP-11 in human astrocytic and oligodendroglial gliomas.
In vivo glioma growth requires host-derived matrix metalloproteinase 2 for maintenance of angioarchitecture.
Increased expression of intracystic matrix metalloproteinases in brain tumors: relationship to the pathogenesis of brain tumor-associated cysts and peritumoral edema.
Modulation of MMP-2 and MMP-9 secretion by cytokines, inducers and inhibitors in human glioblastoma T-98G cells.
Modulation of uPA, MMPs and their inhibitors by a novel nutrient mixture in human glioblastoma cell lines.
Specific matrix metalloproteinase profiles in the cerebrospinal fluid correlated with the presence of malignant astrocytomas, brain metastases, and carcinomatous meningitis.
The effects of exogenous growth factors on matrix metalloproteinase secretion by human brain tumour cells.
[The role of matrix metalloproteinases and tissue inhibitors of metalloproteinases in invasion of tumours of neuroepithelial tissue]
Breast Neoplasms
A drug-delivering-drug strategy for combined treatment of metastatic breast cancer.
A high serum matrix metalloproteinase-2 level is associated with an adverse prognosis in node-positive breast carcinoma.
A matrix metalloproteinase gene expressed in human T lymphocytes is identical with collagenase 3 from breast carcinomas.
A matrix metalloproteinase inhibitor enhances anti-cytotoxic T lymphocyte antigen-4 antibody immunotherapy in breast cancer by reprogramming the tumor microenvironment.
A matrix metalloproteinase inhibitor, batimastat, retards the development of osteolytic bone metastases by MDA-MB-231 human breast cancer cells in Balb C nu/nu mice.
A Multiwell-Based Detection Platform with Integrated PDMS Concentrators for Rapid Multiplexed Enzymatic Assays.
A novel role for the SUMO E3 ligase PIAS1 in cancer metastasis.
A phenotype from tumor stroma based on the expression of metalloproteases and their inhibitors, associated with prognosis in breast cancer.
A randomized phase II feasibility trial of BMS-275291 in patients with early stage breast cancer.
A randomized phase II pilot trial of adjuvant marimastat in patients with early-stage breast cancer.
Activated integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells.
Activating transcription factor 2 mediates matrix metalloproteinase-2 transcriptional activation induced by p38 in breast epithelial cells.
Activity of biphenyl matrix metalloproteinase inhibitor BAY 12-9566 in a human breast cancer orthotopic model.
alpha-Lipoic acid reduces matrix metalloproteinase activity in MDA-MB-231 human breast cancer cells.
Altered metastatic behavior of human breast cancer cells after experimental manipulation of matrix metalloproteinase 8 gene expression.
Amyloid precursor protein promotes the migration and invasion of breast cancer cells by regulating the MAPK signaling pathway.
An assessment of MMP and TIMP gene expression in cell lines and stroma - tumour differences in microdissected breast cancer biopsies.
Anesthetic technique and the cytokine and matrix metalloproteinase response to primary breast cancer surgery.
Anti-invasive activity of sanguinarine through modulation of tight junctions and matrix metalloproteinase activities in MDA-MB-231 human breast carcinoma cells.
Applications of Hairpin DNA-Functionalized Gold Nanoparticles for Imaging mRNA in Living Cells.
Aromatic-turmerone attenuates invasion and expression of MMP-9 and COX-2 through inhibition of NF-?B activation in TPA-induced breast cancer cells.
Aryl Hydrocarbon Receptor in Breast Cancer-A Newly Defined Prognostic Marker.
Assay of matrix metalloproteases types 8 and 9 by ELISA in human breast cancer.
Assignment of the human stromelysin 3 (STMY3) gene to the q11.2 region of chromosome 22.
Association between Expression of Tissue Inhibitors of Metalloproteinases-1, Matrix Metalloproteinase-2, and Matrix Metalloproteinase-9 Genes and Axillary Lymph Nodes Metastasis in Patients with Breast Cancer.
Association of Matrix Metalloproteinase-8 Gene Variation with Breast Cancer Prognosis.
Association of matrix metalloproteinases 3 and 9 single nucleotide polymorphisms with breast cancer risk: A case-control study.
Augmented release of matrix metalloproteinase-9 by PKC activation in organotypic cultures of human breast cancer and adjacent normal breast tissue and fibroadenoma.
Biochemical characterization of human collagenase-3.
Body fluid MMP-2 as a putative biomarker in metastatic breast cancer.
Breast-cancer-associated stromelysin-3 gene is expressed in basal cell carcinoma and during cutaneous wound healing.
Calcium hydroxyapatite promotes mitogenesis and matrix metalloproteinase expression in human breast cancer cell lines.
CCL25 mediates migration, invasion and matrix metalloproteinase expression by breast cancer cells in a CCR9-dependent fashion.
CD44v(3,8-10) is involved in cytoskeleton-mediated tumor cell migration and matrix metalloproteinase (MMP-9) association in metastatic breast cancer cells.
Cell density-dependent regulation of matrix metalloproteinase and TIMP expression in differently tumorigenic breast cancer cell lines.
Circulating MMP2 and MMP9 in breast cancer -- potential role in classification of patients into low risk, high risk, benign disease and breast cancer categories.
Cleavage of Syndecan-1 Promotes the Proliferation of the Basal-Like Breast Cancer Cell Line BT-549 Via Akt SUMOylation.
Clinical evidence for a protective role of lipocalin-2 against MMP-9 autodegradation and the impact for gastric cancer.
Collagenase 3 (matrix metalloproteinase 13) gene expression by HaCaT keratinocytes is enhanced by tumor necrosis factor alpha and transforming growth factor beta.
Collagenase-3 (MMP-13) expression in chondrosarcoma cells and its regulation by basic fibroblast growth factor.
Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development.
Collagenase-3 expression is associated with advanced local invasion in human squamous cell carcinomas of the larynx.
Common matrix metalloproteinase-2 gene variants and altered susceptibility to breast cancer and associated features in Tunisian women.
Correction: The anti-metastatic activity of collagenase-2 in breast cancer cells is mediated by a signaling pathway involving decorin and miR-21.
Crosstalk between TGF-? signaling and miRNAs in breast cancer metastasis.
CRP2, a new invadopodia actin bundling factor critically promotes breast cancer cell invasion and metastasis.
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Determining the dynamics of cancer cell secretion.
Development of a Radiolabeled Peptide-Based Probe Targeting MT1-MMP for Breast Cancer Detection.
Differential effects of transforming growth factor-beta on the expression of collagenase-1 and collagenase-3 in human fibroblasts.
Distribution of stromelysin-3 mRNA transcripts and microvessels in human breast carcinomas.
Downregulation of caveolin-1 promotes murine breast cancer cell line progression by highly glycosylated CD147.
Downregulation of Integrins in Cancer Cells and Anti-Platelet Properties Are Involved in Holothurian Glycosaminoglycan-Mediated Disruption of the Interaction of Cancer Cells and Platelets in Hematogenous Metastasis.
Dual MMP7-proximity-activated and folate receptor-targeted nanoparticles for siRNA delivery.
Dynamics of internalization and recycling of the prometastatic membrane type 4 matrix metalloproteinase (MT4-MMP) in breast cancer cells.
Dysregulation of adenosine kinase isoforms in breast cancer.
Effect of GnT-V knockdown on the proliferation, migration and invasion of the SMMC7721/R human hepatocellular carcinoma drug-resistant cell line.
Effect of matrix metalloproteinase inhibitor batimastat on breast cancer regrowth and metastasis in athymic mice.
Effect of methanolic and water extract of Leucobryum bowringii Mitt. on growth, migration and invasion of MCF 7 human breast cancer cells in vitro.
Estradiol and tamoxifen regulate endostatin generation via matrix metalloproteinase activity in breast cancer in vivo.
Estrogenic and antiestrogenic effects of raloxifene on collagen metabolism in breast cancer MCF-7 cells.
Expression and regulation of collagenase-3 (MMP-13) in human malignant tumors.
Expression of collagenase-3 in the rat ovary during the ovulatory process.
Expression of Ets-related transcription factors and matrix metalloproteinase genes in human breast cancer cells.
Expression of matrix metalloproteinase (MMP)-2 and MMP-9 in breast cancer with a special reference to activator protein-2, HER2, and prognosis.
Expression of matrix metalloproteinase 8 (MMP-8) and tyrosinase-related protein-1 (TYRP-1) correlates with the absence of metastasis in an isogenic human breast cancer model.
Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response.
Expression of neurotensin and NT1 receptor in human breast cancer: a potential role in tumor progression.
Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim.
Fisetin regulates TPA-induced breast cell invasion by suppressing matrix metalloproteinase-9 activation via the PKC/ROS/MAPK pathways.
Gelatinase A, membrane type 1 matrix metalloproteinase, and extracellular matrix metalloproteinase inducer mRNA expression: correlation with invasive growth of breast cancer.
Genetic and Pharmacologic Inhibition of eIF4E Reduces Breast Cancer Cell Migration, Invasion, and Metastasis.
Hsa-miR-206 represses the proliferation and invasion of breast cancer cells by targeting Cx43.
Human brain endothelial cell-derived COX-2 facilitates extravasation of breast cancer cells across the blood-brain barrier.
Human breast cancer cell-mediated bone collagen degradation requires plasminogen activation and matrix metalloproteinase activity.
Hydrolytic inactivation of a breast carcinoma cell-derived serpin by human stromelysin-3.
Imaging Matrix Metalloproteinase Activity Implicated in Breast Cancer Progression.
Immunolocalization of MMP9 and MMP2 in osteolytic metastasis originating from MDA-MB-231 human breast cancer cells.
Immunological characterization of cell-surface and soluble forms of membrane type 1 matrix metalloproteinase in human breast cancer cells and in fibroblasts.
In situ injection of dual-delivery PEG based MMP-2 sensitive hydrogels for enhanced tumor penetration and chemo-immune combination therapy.
Increased precision of orthotopic and metastatic breast cancer surgery guided by matrix metalloproteinase-activatable near-infrared fluorescence probes.
Induction of apoptosis and inhibition of c-erbB-2 in breast cancer cells by flavopiridol.
Induction of metalloproteinase (MMP1) expression by epidermal growth factor (EGF) receptor stimulation and serum deprivation in human breast tumour cells.
Inhibition of Breast Cancer Metastasis by Presurgical Treatment with an Oral Matrix Metalloproteinase Inhibitor: A Preclinical Proof-of-Principle Study.
Inhibition of cell invasion and migration by CEACAM1-4S in breast cancer.
Inhibition of cyclooxygenase-2 decreases breast cancer cell motility, invasion and matrix metalloproteinase expression.
Inhibition of human MDA-MB-231 breast cancer cell invasion by matrix metalloproteinase 3 involves degradation of plasminogen.
Integrin fibronectin receptors in matrix metalloproteinase-1-dependent invasion by breast cancer and mammary epithelial cells.
Is collagenase-3 (MMP-13) expression in chondrosarcoma of the jaws a true marker for tumor aggressiveness?
KLF8 promotes human breast cancer cell invasion and metastasis by transcriptional activation of MMP9.
Loquat (Eriobotrya japonica) extracts suppress the adhesion, migration and invasion of human breast cancer cell line.
Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function.
Low serum MMP-1 in breast cancer: a negative prognostic factor?
Matrix metalloproteinase (MMP)-1 and MMP-3 gene variations affect MMP-1 and -3 serum concentration and associates with breast cancer.
Matrix metalloproteinase 13 is induced in fibroblasts in polyomavirus middle T antigen-driven mammary carcinoma without influencing tumor progression.
Matrix metalloproteinase 26 proteolysis of the NH2-terminal domain of the estrogen receptor beta correlates with the survival of breast cancer patients.
Matrix metalloproteinase 8 (collagenase 2) induces the expression of interleukins 6 and 8 in breast cancer cells.
Matrix metalloproteinase expression and outcome in patients with breast cancer: analysis of a published database.
Matrix metalloproteinase expression in breast cancer.
Matrix metalloproteinase expression in human breast cancer: an immunohistochemical study including correlation with cathepsin D, type IV collagen, laminin, fibronectin, EGFR, c-erbB-2 oncoprotein, p53, steroid receptors status and proliferative indices.
Matrix metalloproteinase expression patterns in luminal A type breast carcinomas.
Matrix metalloproteinase genes are associated with breast cancer risk and survival: the Breast Cancer Health Disparities Study.
Matrix metalloproteinase inhibitor reversion-inducing cysteine-rich protein with Kazal motifs: a prognostic marker for good clinical outcome in human breast carcinoma.
Matrix metalloproteinase inhibitors: past lessons and future prospects in breast cancer.
Matrix metalloproteinase single-nucleotide polymorphisms and haplotypes predict breast cancer progression.
Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion.
Matrix metalloproteinase?2 regulates MDA?MB?231 breast cancer cell invasion induced by active mammalian diaphanous-related formin 1.
Matrix metalloproteinases and metastatic cancer.
Matrix metalloproteinases are involved in both type I (apoptosis) and type II (autophagy) cell death induced by sodium phenylacetate in MDA-MB-231 breast tumour cells.
Matrix metalloproteinases as breast cancer drivers and therapeutic targets.
MBP-1 inhibits breast cancer growth and metastasis in immunocompetent mice.
Melatonin inhibits TPA-induced oral cancer cell migration by suppressing matrix metalloproteinase-9 activation through the histone acetylation.
Membrane-Type 4 Matrix Metalloproteinase (MT4-MMP) induces lung metastasis by alteration of primary breast tumor vascular architecture.
Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases.
Metastasis is strongly reduced by the matrix metalloproteinase inhibitor Galardin in the MMTV-PymT transgenic breast cancer model.
Microarray and proteomic analysis of breast cancer cell and osteoblast co-cultures: the role of osteoblast matrix metalloproteinase (MMP)-13 in bone metastasis.
Modulation of monocyte matrix metalloproteinase-2 by breast adenocarcinoma cells.
Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas.
Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma.
Monoclonal anti?MUC1 antibody with novel octahydropyrazino[2,1?a:5,4?a']diisoquinoline derivative as a potential multi?targeted strategy in MCF?7 breast cancer cells.
Myricetin suppresses breast cancer metastasis through down-regulating the activity of matrix metalloproteinase (MMP)-2/9.
Novel strategy in breast cancer therapy: Revealing the bright side of ginsenosides.
Oldenlandia diffusa suppresses metastatic potential through inhibiting matrix metalloproteinase-9 and intercellular adhesion molecule-1 expression via p38 and ERK1/2 MAPK pathways and induces apoptosis in human breast cancer MCF-7 cells.
Oleuropein induces anti-metastatic effects in breast cancer.
Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells' malignant phenotypes: role of tissue inhibitors of metalloproteinase-1.
Perioperative propofol-paravertebral anesthesia decreases the metastasis and progression of breast cancer.
Plasma matrix metalloproteinases 7 and 9 in patients with metastatic breast cancer treated with marimastat or placebo: Eastern Cooperative Oncology Group trial E2196.
Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice.
Potential Role of Phytochemicals Against Matrix Metalloproteinase Induced Breast Cancer; An Explanatory Review.
Prevalence of vascular-endothelial growth factor, matrix metalloproteinases and tissue inhibitors of metalloproteinases in primary breast cancer.
Production of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human breast carcinomas.
Protein kinase D1 inhibits breast cancer cell invasion via regulating matrix metalloproteinase expression.
Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion.
Proteinases As Biomarkers In Breast Cancer Prognosis And Diagnosis.
Proteomic validation of protease drug targets: pharmacoproteomics of matrix metalloproteinase inhibitor drugs using isotope-coded affinity tag labelling and tandem mass spectrometry.
Randomized phase III trial of marimastat versus placebo in patients with metastatic breast cancer who have responding or stable disease after first-line chemotherapy: Eastern Cooperative Oncology Group trial E2196.
Receptor activator of NF-kappaB ligand enhances breast cancer-induced osteolytic lesions through upregulation of extracellular matrix metalloproteinase inducer/CD147.
Recombination of CXCR4, VEGF, and MMP-9 predicting lymph node metastasis in human breast cancer.
Regulation of collagenase-3 expression in human breast carcinomas is mediated by stromal-epithelial cell interactions.
Regulation of extracellular matrix metalloproteinase inducer and matrix metalloproteinase expression by amphiregulin in transformed human breast epithelial cells.
Relationship between matrix metalloproteinase expression and tumor angiogenesis in human breast carcinoma.
Replication study for reported SNP associations with breast cancer survival.
Requirement for matrix metalloproteinase stromelysin-3 in cell migration and apoptosis during tissue remodeling in Xenopus laevis.
Resveratrol inhibits heregulin-beta1-mediated matrix metalloproteinase-9 expression and cell invasion in human breast cancer cells.
Serum cytokine profile in patients with breast cancer.
Serum TIMP-1 predicts survival outcomes of invasive breast carcinoma patients: a meta-analysis.
Short-hairpin RNA-mediated MTA2 silencing inhibits human breast cancer cell line MDA-MB231 proliferation and metastasis.
SKA2 mediates invasion and metastasis in human breast cancer via EMT.
SPIONs embedded in polyamino acid nanogels to synergistically treat tumor microenvironment and breast cancer cells.
Stat5 promotes homotypic adhesion and inhibits invasive characteristics of human breast cancer cells.
Statins and breast cancer: may matrix metalloproteinase be the missing link.
Stromelysin 3 belongs to a subgroup of proteinases expressed in breast carcinoma fibroblastic cells and possibly implicated in tumor progression.
Stromelysin-3 is overexpressed by stromal elements in primary non-small cell lung cancers and regulated by retinoic acid in pulmonary fibroblasts.
Structural analysis and promoter characterization of the human collagenase-3 gene (MMP13).
Substrate specificity of Xenopus matrix metalloproteinase stromelysin-3.
Synthesis and preliminary biological evaluation of MMP inhibitor radiotracers [11C]methyl-halo-CGS 27023A analogs, new potential PET breast cancer imaging agents.
Synthetic matrix metalloproteinase inhibitors inhibit growth of established breast cancer osteolytic lesions and prolong survival in mice.
TAK1-TAB2 Signaling Contributes to Bone Destruction by Breast Carcinoma Cells.
Tamoxifen decreases extracellular TGF-beta1 secreted from breast cancer cells--a post-translational regulation involving matrix metalloproteinase activity.
Targeting hyaluronan interactions in spinal cord astrocytomas and diffuse pontine gliomas.
The anti-metastatic activity of collagenase-2 in breast cancer cells is mediated by a signaling pathway involving decorin and miR-21.
The Association of Matrix Metalloproteinase-8 Promoter Genotypes in Breast Cancer.
The breast cancer-associated stromelysin-3 gene is expressed during mouse mammary gland apoptosis.
The effect of opine on matrix metalloproteinase expression in mice with breast cancer.
The effect of tomatine on metastasis related matrix metalloproteinase (MMP) activities in breast cancer cell model.
The Ets-1 transcription factor is up-regulated together with MMP 1 and MMP 9 in the stroma of pre-invasive breast cancer.
The helping hand of collagenase-3 (MMP-13): 2.7 A crystal structure of its C-terminal haemopexin-like domain.
The human collagenase-3 (CLG3) gene is located on chromosome 11q22.3 clustered to other members of the matrix metalloproteinase gene family.
The matrix metalloproteinase inhibitor batimastat (BB-94) retards human breast cancer solid tumor growth but not ascites formation in nude mice.
Therapeutic Potential of Matrix Metalloproteinase Inhibition in Breast Cancer.
Thidiazuron decreases epithelial-mesenchymal transition activity through the NF-kB and PI3K/AKT signalling pathways in breast cancer.
Thioredoxin stimulates MMP-9 expression, de-regulates the MMP-9/TIMP-1 equilibrium and promotes MMP-9 dependent invasion in human MDA-MB-231 breast cancer cells.
Toll-Like Receptor 9 Agonists Promote Cellular Invasion by Increasing Matrix Metalloproteinase Activity.
Toll-like receptor 9 agonists promote cellular invasion by increasing matrix metalloproteinase activity.
Transcriptional control of cell density dependent regulation of matrix metalloproteinase and TIMP expression in breast cancer cell lines.
Two-photon laser-generated microtracks in 3D collagen lattices: principles of MMP-dependent and -independent collective cancer cell invasion.
Up-regulation of miR-182 by ?-catenin in breast cancer increases tumorigenicity and invasiveness by targeting the matrix metalloproteinase inhibitor RECK.
Using caffeoyl pyrrolidine derivative LY52, a potential inhibitor of matrix metalloproteinase-2, to suppress tumor invasion and metastasis.
USP4 promotes invasion of breast cancer cells via Relaxin/TGF-?1/Smad2/MMP-9 signal.
Valproic acid modulates radiation-enhanced matrix metalloproteinase activity and invasion of breast cancer cells.
Wortmannin Reduces Metastasis and Angiogenesis of Human Breast Cancer Cells via Nuclear Factor- B-dependent Matrix Metalloproteinase-9 and Interleukin-8 Pathways.
Zinc stable isotope analysis reveals Zn dyshomeostasis in benign tumours, breast cancer, and adjacent histologically normal tissue.
ZKSCAN3 promotes breast cancer cell proliferation, migration and invasion.
[A Simple Medical Research Microdevice for Analyzing Three-dimensional Migration of Tumor Cells in Vitro].
[Expression of CD147, matrix metalloproteinases and transforming growth factor beta1 in breast cancer]
[Expression of matrix metalloproteinase (MMP-2) and extracellular matrix metalloproteinases inducer (EMMPRIN) in benign and advanced breast cancer tissue samples]
[Relationship between LKB1 gene and invasion-related factors of breast cancer cells]
[Relationship between lymph node metastasis and the expressions of E-cadherin, N-cadherin, and matrix metalloproteinase in breast carcinoma]
[Role of matrix metalloproteinase (MMP)-2 and -9 and vascular endothelial growth factor C in lymph node metastasis of breast cancer.]
Bronchiectasis
Collagenase-2 and -3 are inhibited by doxycycline in the chronically inflamed lung in bronchiectasis.
Human neutrophil collagenase (MMP-8), identified in bronchiectasis BAL fluid, correlates with severity of disease.
In vivo collagenase-2 (MMP-8) expression by human bronchial epithelial cells and monocytes/macrophages in bronchiectasis.
Lack of association between matrix metalloproteinase 8 promoter polymorphism and bronchiectasis in Koreans.
Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis.
Matrix Metalloproteinases Vary with Airway Microbiota Composition and Lung Function in Non-Cystic Fibrosis Bronchiectasis.
Potentiative effects of neutral proteinases in an inflamed lung: relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo.
Sputum matrix metalloproteinase-8 and -9 and tissue inhibitor of metalloproteinase-1 in bronchiectasis: clinical correlates and prognostic implications.
Bronchiolitis
Editorial: leukocyte trafficking and matrix metalloproteinase-8 in obliterative bronchiolitis.
Matrix metalloproteinase induction in post-transplant obliterative bronchiolitis.
MMP-8 promotes polymorphonuclear cell migration through collagen barriers in obliterative bronchiolitis.
Bronchitis, Chronic
Increased serum concentrations of tissue inhibitor of metalloproteinase-1 in COPD patients.
Bronchopulmonary Dysplasia
Angiogenesis-related genes may be a more important factor than matrix metalloproteinases in bronchopulmonary dysplasia development.
Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development.
Matrix Metalloproteinase-9 Deficiency Worsens Lung Injury in a Model of Bronchopulmonary Dysplasia.
Bursitis
Dupuytren's disease and frozen shoulder induced by treatment with a matrix metalloproteinase inhibitor.
Matrix metalloproteinase, tissue inhibitor of metalloproteinase and transforming growth factor-beta 1 in frozen shoulder, and their changes as response to intensive stretching and supervised neglect exercise.
Calcinosis
GALNT3, a gene associated with hyperphosphatemic familial tumoral calcinosis, is transcriptionally regulated by extracellular phosphate and modulates matrix metalloproteinase activity.
Capsule Opacification
[Experimental study on effects of matrix metalloproteinase inhibitor on posterior capsule opacification in rabbits].
Carcinogenesis
A polymorphism in the matrix metalloproteinase-1 gene promoter is associated with the prognosis of patients with ovarian cancer.
Association of Matrix Metalloproteinase-8 Gene Variation with Breast Cancer Prognosis.
Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion.
Cell Specific Matrix Metalloproteinase-1 Regulates Lung Metastasis Synergistically with Smoke Exposure.
Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer.
Concurrent PEDF deficiency and Kras mutation induce invasive pancreatic cancer and adipose-rich stroma in mice.
Correlation and prognostic significance of MMP-2 and TFPI-2 differential expression in pancreatic carcinoma.
Different Role of Caveolin-1 Gene in the Progression of Gynecological Tumors.
Differential expression of matrilysin and cyclooxygenase-2 in intestinal and colorectal neoplasms.
Epidermal growth factor upregulates matrix metalloproteinase-7 expression through activation of PEA3 transcription factors.
Expression of matrix metalloproteinase 8 (MMP-8) and tyrosinase-related protein-1 (TYRP-1) correlates with the absence of metastasis in an isogenic human breast cancer model.
Expression of matrix metalloproteinases in gallbladder carcinoma and their significance in carcinogenesis.
Expression of stromelysin-1 and TIMP-1 in the involuting mammary gland and in early invasive tumors of the mouse.
Fli?1 promotes metastasis by regulating MMP2 signaling in hepatocellular carcinoma.
Galangin and Kaempferol Suppress Phorbol-12-Myristate-13-Acetate-Induced Matrix Metalloproteinase-9 Expression in Human Fibrosarcoma HT-1080 Cells.
Glycoprotein non-metastatic melanoma protein B promotes glioma motility and angiogenesis through the Wnt/?-catenin signaling pathway.
High Matrix Metalloproteinase 28 Expression is Associated with Poor Prognosis in Pancreatic Adenocarcinoma.
Inflammatory and tumorigenic effects of environmental pollutants found in particulate matter on lung epithelial cells.
Influence of HPV16 E2 and its localisation on the expression of matrix metalloproteinase-9.
Inhibition of enzyme activity of and cell-mediated substrate cleavage by membrane type 1 matrix metalloproteinase by newly developed mercaptosulphide inhibitors.
Interleukin 8 expression regulates tumorigenicity and metastasis in human bladder cancer.
Interplay of insulin-like growth factor-II, insulin-like growth factor-I, insulin-like growth factor-I receptor, COX-2, and matrix metalloproteinase-7, play key roles in the early stage of colorectal carcinogenesis.
Luteolin inhibits matrix metalloproteinase 9 and 2 in azoxymethane-induced colon carcinogenesis.
Matrix metalloproteinase inhibition attenuates human pancreatic cancer growth in vitro and decreases mortality and tumorigenesis in vivo.
Matrix metalloproteinase-11 overexpressed in lobular carcinoma cells of the breast promotes anoikis resistance.
Meta-analysis of MMP2, MMP3, and MMP9 promoter polymorphisms and head and neck cancer risk.
miR?378a?3p exerts tumor suppressive function on the tumorigenesis of esophageal squamous cell carcinoma by targeting Rab10.
MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis.
MMP2 promoter polymorphism (C-1306T) and risk of recurrence in patients with hepatocellular carcinoma after transplantation.
MMP9 polymorphisms and breast cancer risk: a report from the Shanghai Breast Cancer Genetics Study.
New target therapies in advanced pancreatic cancer.
No Association of Matrix Metalloproteinase [MMP]-2 (-735C > T) and Tissue Inhibitor of Metalloproteinase [TIMP]-2 (-418G > C) Gene Polymorphisms with Cervical Cancer Susceptibility.
Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism.
Overexpression of poly(ADP-ribose) polymerase-1 (PARP-1) in the early stage of colorectal carcinogenesis.
Pirfenidone inhibits TGF-beta expression in malignant glioma cells.
Pivotal involvement of the CX3CL1-CX3CR1 axis for the recruitment of M2 tumor-associated macrophages in skin carcinogenesis.
Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice.
Regulation of pituitary hormones and cell proliferation by components of the extracellular matrix.
Role of matrix metalloproteinases in colorectal carcinogenesis.
STAT3 activation is required for interleukin-6 induced transformation in tumor-promotion sensitive mouse skin epithelial cells.
Stimulation of mammary tumorigenesis by systemic tissue inhibitor of matrix metalloproteinase 4 gene delivery.
Synthesis and evaluation of a novel fluorescent photoprobe for imaging matrix metalloproteinases.
Testosterone-induced matrix metalloproteinase activation is a checkpoint for neuronal addition to the adult songbird brain.
The matrix metalloproteinase matrilysin influences early-stage mammary tumorigenesis.
The role of a single nucleotide polymorphism of the matrix metalloproteinase-1 gene promoter region in invasion and prognosis of meningiomas.
Trichostatin A-histone deacetylase inhibitor with clinical therapeutic potential-is also a selective and potent inhibitor of gelatinase A expression.
Upregulated expression of MMP-9 in gingival epithelial cells induced by prolonged stimulation with arecoline.
Upregulated matrix metalloproteinase-2 and downregulated tissue factor pathway inhibitor-2 are risk factors for lymph node metastasis and perineural invasion in pancreatic carcinoma.
[Expression and clinical significance of matrix metalloproteinase-26 in non-small cell lung cancer.]
[The matrix metalloproteinase in oral and oropharyngeol cancer - literature review].
Carcinoid Tumor
Correlation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinase expression in ileal carcinoids, lymph nodes and liver metastasis with prognosis and survival.
Carcinoma
(-)-Epigallocatechin-3-gallate (EGCG) inhibits HGF-induced invasion and metastasis in hypopharyngeal carcinoma cells.
A circular RNA derived from MMP9 facilitates oral squamous cell carcinoma metastasis through regulation of MMP9 mRNA stability.
A novel functional site of extracellular matrix metalloproteinase inducer (EMMPRIN) that limits the migration of human uterine cervical carcinoma cells.
A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts.
Aberrant expression, processing and degradation of dystroglycan in squamous cell carcinomas.
Acid-electrolyzed functional water induces extracellular matrix metalloproteinase inducer, a possible novel alarmin, secretion from oral squamous cell carcinoma cell lines.
Alpha-mangostin suppresses MMP-2 and MMP-9 expression in head and neck squamous carcinoma cells.
An immunohistochemical study of TIMP-3 expression in oesophageal squamous cell carcinoma.
Analysis of the gene-expression profile regarding the progression of human gastric carcinoma.
Annexin A1 expression is correlated with malignant potential of renal cell carcinoma.
Anti-EMMPRIN antibody treatment of head and neck squamous cell carcinoma in an ex-vivo model.
Anti-invasive activities of anthocyanins through modulation of tight junctions and suppression of matrix metalloproteinase activities in HCT-116 human colon carcinoma cells.
Anti-invasive activity of ethanol extracts of Ganoderma lucidum through tightening of tight junctions and inhibition of matrix metalloproteinase activities in human gastric carcinoma cells.
Anti-invasive effect of MMI-166, a new selective matrix metalloproteinase inhibitor, in cervical carcinoma cell lines.
Anti-invasive effects of decitabine, a DNA methyltransferase inhibitor, through tightening of tight junctions and inhibition of matrix metalloproteinase activities in AGS human gastric carcinoma cells.
Antibody microarray-based technology to rapidly define matrix metalloproteinase (MMP) signatures in patients undergoing resection for primary gastric carcinoma.
Anticancer Efficacy of Polyphenols and Their Combinations.
Association of a haplotype of matrix metalloproteinase (MMP)-1 and MMP-3 polymorphisms with renal cell carcinoma.
Association of functional polymorphisms in MMPs genes with gastric cardia adenocarcinoma and esophageal squamous cell carcinoma in high incidence region of North China.
Association of matrix metalloproteinase (MMP)-1 promoter polymorphism with head and neck squamous cell carcinoma.
Biobehavioral influences on matrix metalloproteinase expression in ovarian carcinoma.
Caveolin-1 promotes an invasive phenotype and predicts poor prognosis in large cell lung carcinoma.
Caveolin-1 regulating the invasion and expression of matrix metalloproteinase (MMPs) in pancreatic carcinoma cells.
Characteristics of a 95-kDa matrix metalloproteinase produced by mammary carcinoma cells.
Characterization of monoclonal antibodies against stromelysin-3 and their use to evaluate stromelysin-3 levels in breast carcinoma by semi-quantitative immunohistochemistry.
Circulating 92-kilodalton matrix metalloproteinase (MMP-9) activity is enhanced in the euglobulin plasma fraction of head and neck squamous cell carcinoma.
Cleavage of beta 4 integrin by matrilysin.
Clinicopathologic significance of fascin, extracellular matrix metalloproteinase inducer, and ezrin expressions in colorectal adenocarcinoma.
Clinicopathological Significance of Matrix Metalloproteinase-2 Protein Expression in Renal Cell Carcinoma Patients.
Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation.
Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer.
Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas.
Combined treatment with serine protease inhibitor aprotinin and matrix metalloproteinase inhibitor Batimastat (BB-94) does not prevent invasion of human esophageal and ovarian carcinoma cells in vivo.
Control of lymphatic and hematogenous metastasis of a rat mammary carcinoma by the matrix metalloproteinase inhibitor batimastat (BB-94).
Correlation between vascular endothelial growth factor-C expression and invasion phenotype in cervical carcinomas.
Correlation of matrix metalloproteinase suppressor genes RECK, VEGF, and CD105 with angiogenesis and biological behavior in esophageal squamous cell carcinoma.
Correlation of matrix metalloproteinase-2, -9, tissue inhibitor-1 of matrix metalloproteinase and CD44 variant 6 in head and neck cancer metastasis.
Correlation of the in situ detection of polymerase chain reaction-amplified metalloproteinase complementary DNAs and their inhibitors with prognosis in cervical carcinoma.
Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment.
Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification.
Cytoplasmic and nuclear maspin expression in lung carcinomas: an immunohistochemical study using tissue microarrays.
Demonstration in vivo that stromelysin-3 functions through its proteolytic activity.
Differential expression in normal-adenoma-carcinoma sequence suggests complex molecular carcinogenesis in colon.
Differential expression of degradome components in cutaneous squamous cell carcinomas.
Differential expression of matrix metalloproteinase-2 by fibroblasts in co-cultures with keratinocytes, basal cell carcinoma and melanoma.
Differential expression of MMP and uPA systems and prognostic relevance of their expression in esophageal squamous cell carcinoma.
Differential matrix metalloproteinase levels in adenocarcinoma and squamous cell carcinoma of the lung.
Divergent Matrix-Remodeling Strategies Distinguish Developmental from Neoplastic Mammary Epithelial Cell Invasion Programs.
Downregulation of MACC1 inhibits invasion, migration and proliferation, attenuates cisplatin resistance and induces apoptosis in tongue squamous cell carcinoma.
DSPP-MMP20 gene silencing downregulates cancer stem cell markers in human oral cancer cells.
Dual regulation of stromelysin-3 by fibroblast growth factor-2 in murine osteoblasts.
Dupuytren's disease and frozen shoulder induced by treatment with a matrix metalloproteinase inhibitor.
Effect of a matrix metalloproteinase inhibitor (ONO-4817) on lung metastasis of murine renal cell carcinoma.
Effect of duration of fixation on quantitative reverse transcription polymerase chain reaction analyses.
Effects of cytokines on matrix metalloproteinase expression in oral squamous cell carcinoma in vitro.
Effects of matrix metalloproteinase inhibitor doxycycline and CD147 antagonist peptide-9 on gallbladder carcinoma cell lines.
EMMPRIN (extracellular matrix metalloproteinase inducer) is a novel marker of poor outcome in serous ovarian carcinoma.
EMMPRIN expression in oral SCC is regulated by FYN kinase.
EMMPRIN expression in oral squamous cell carcinomas: correlation with tumor proliferation and patient survival.
EMMPRIN Promotes Angiogenesis, Proliferation, Invasion and Resistance to Sunitinib in Renal Cell Carcinoma, and Its Level Predicts Patient Outcome.
EMMPRIN-induced MMP-2 activation cascade in human cervical squamous cell carcinoma.
Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia.
Endothelin-1 induces tumor proteinase activation and invasiveness of ovarian carcinoma cells.
Endothelin-1-induced prostaglandin E2-EP2, EP4 signaling regulates vascular endothelial growth factor production and ovarian carcinoma cell invasion.
Enhanced inhibitory effect of the matrix metalloproteinase inhibitor Ro 28-2653 in combination with estramustine and etoposide on the prostate carcinoma in the rat Dunning orthotopic tumor model.
Enhanced production and activation of matrix metalloproteinase-7 (matrilysin) in human endometrial carcinomas.
Enhanced production of matrix metalloproteinase-2 in human head and neck carcinomas is correlated with lymph node metastasis.
Estimation of serum and salivary matrix metalloproteinase levels in oral squamous cell carcinoma patients: a systematic review and meta-analysis.
Euterpe oleracea extract inhibits tumorigenesis effect of the chemical carcinogen DMBA in breast experimental cancer.
Exercise modulates platelet-nasopharyngeal carcinoma cell aggregation and subsequent tissue factor and matrix metalloproteinase activities.
Expression and correlation of CD44v6, vascular endothelial growth factor, matrix metalloproteinase-2, and matrix metalloproteinase-9 in Krukenberg tumor.
Expression and localization of the matrix metalloproteinase pump-1 (MMP-7) in human gastric and colon carcinomas.
Expression and regulation of collagenase-2 (MMP-8) in head and neck squamous cell carcinomas.
Expression levels of matrix metalloproteinase-9 in human gastric carcinoma.
Expression of collagenase-3 (MMP-13) and collagenase-1 (MMP-1) by transformed keratinocytes is dependent on the activity of p38 mitogen-activated protein kinase.
Expression of cyclooxygenase-2 and matrix metalloproteinase-9 in gastric carcinoma and its correlation with angiogenesis.
Expression of extracellular matrix metalloproteinase inducer and enhancement of the production of matrix metalloproteinase-1 in tongue squamous cell carcinoma.
Expression of FLJ10540 is correlated with aggressiveness of oral cavity squamous cell carcinoma by stimulating cell migration and invasion through increased FOXM1 and MMP-2 activity.
Expression of invasion markers CD44v6/v3, NM23 and MMP2 in laryngeal and hypopharyngeal carcinoma.
Expression of matrix metalloproteinase 1, matrix metalloproteinase 2, and matrix metalloproteinase 9 in carcinoma of the head and neck.
Expression of matrix metalloproteinase-10 in renal cell carcinoma and its prognostic role.
Expression of matrix metalloproteinases in feline vaccine site-associated sarcomas.
Expression of matrix metalloproteinases in gallbladder carcinoma and their significance in carcinogenesis.
Expression of matrix metalloproteinases in gastric carcinoma and possibility of clinical application of matrix metalloproteinase inhibitor in vivo.
Expression of metalloproteinase-2, metalloproteinase-9, and tissue inhibitor of metalloproteinase-1 in transitional cell carcinoma of upper urinary tract: correlation with tumor stage and survival.
Expression of metalloproteinases and their tissue inhibitors in squamous cell laryngeal carcinoma.
Expression of mRNA MMP-7 and mRNA TIMP-1 in non-small cell lung cancer.
Expression of the matrix metalloproteinase promatrilysin in coculture of prostate carcinoma cell lines.
Expression of the stromelysin-3 gene in fibroblastic cells of invasive carcinomas of the breast and other human tissues: a review.
Expression of tissue inhibitor of matrix metalloproteinase-1 in human breast carcinoma.
Expression of type IV collagen and its degrading enzymes in squamous cell carcinoma of lung.
Expressions of E-cadherin, Cortactin and MMP-9 in Pseudoepitheliomatous Hyperplasia and Squamous Cell Carcinoma of the Head and Neck: Their Relationships with Clinicopathologic Factors and Prognostic Implication.
Extracellular matrix metalloproteinase inducer expression in histological grades of oral squamous cell carcinoma - An immunohistochemical study.
Extracellular matrix metalloproteinase inducer expression in salivary gland tumors: a correlation with microvessel density.
Extracellular vesicles originating from glioblastoma cells increase metalloproteinase release by astrocytes: the role of CD147 (EMMPRIN) and ionizing radiation.
Fusobacteria modulate oral carcinogenesis and promote cancer progression.
Gelatinolytic activity of matrix metalloproteinase-2 and -9 in oesophageal carcinoma; a study using in situ zymography.
Hepatocyte growth factor upregulates E1AF that induces oral squamous cell carcinoma cell invasion by activating matrix metalloproteinase genes.
High expression levels of nuclear factor kappa B and gelatinases in the tumorigenesis of oral squamous cell carcinoma.
High VEGF-D and Low MMP-2 Serum Levels Predict Nodal-Positive Disease in Invasive Bladder Cancer.
Human collagenase-3 is expressed in malignant squamous epithelium of the skin.
Human keratinocytes express EMMPRIN, an extracellular matrix metalloproteinase inducer.
Human neutrophil peptide-1 affects matrix metalloproteinase-2, -8 and -9 secretions of oral squamous cell carcinoma cell lines in vitro.
Identification of an active site of EMMPRIN for the augmentation of matrix metalloproteinase-1 and -3 expression in a co-culture of human uterine cervical carcinoma cells and fibroblasts.
Identification of structural determinants controlling human and mouse stromelysin-3 proteolytic activities.
Imatinib-associated matrix metalloproteinase suppression in p16-positive squamous cell carcinoma compared to HPV-negative HNSCC cells in vitro.
Immunohistochemical expression of CD44, matrix metalloproteinase2 and matrix metalloproteinase9 in renal cell carcinomas.
Immunohistochemical expression of epidermal growth factor receptor, E-cadherin, and matrix metalloproteinase-9 in ovarian epithelial cancer and relation to patient deaths.
Immunohistochemical expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma.
Immunohistochemical expression of MMP-2 and MMP-8 in oral squamous cell carcinoma.
Immunohistochemical predictors in squamous cell carcinoma of the tongue and floor of the mouth.
Impedimetric toxicity assay in microfluidics using free and liposome-encapsulated anticancer drugs.
In situ detection of PCR-amplified metalloproteinase cDNAs, their inhibitors and human papillomavirus transcripts in cervical carcinoma cell lines.
Increased expression of matrix metalloproteinase-2 and 9 and human papilloma virus infection are associated with malignant transformation of sinonasal inverted papilloma.
Increased matrix metalloproteinase activation in esophageal squamous cell carcinoma.
Increased stromelysin 3 gene expression is associated with increased local invasiveness in head and neck squamous cell carcinomas.
Inducing regulated necrosis and shifting macrophage polarization with anti-EMMPRIN antibody (161-pAb) and complement factors.
Inhibiting Invasion into Human Bladder Carcinoma 5637 Cells with Diallyl Trisulfide by Inhibiting Matrix Metalloproteinase Activities and Tightening Tight Junctions.
Inhibition of Matrix Metalloproteinase Activities and Tightening of Tight Junctions by Diallyl Disulfide in AGS Human Gastric Carcinoma Cells.
Inhibition of organ invasion by the matrix metalloproteinase inhibitor batimastat (BB-94) in two human colon carcinoma metastasis models.
Inhibitory effect of a matrix metalloproteinase inhibitor on growth and spread of human pancreatic ductal adenocarcinoma evaluated in an orthotopic severe combined immunodeficient (SCID) mouse model.
Insulin-like growth factor-I receptor blockade reduces the invasiveness of gastrointestinal cancers via blocking production of matrilysin.
Interleukin-6 as a potential molecular target in esophageal squamous cell carcinoma.
Involvement of inactive GSK3beta overexpression in tumorigenesis and progression of gastric carcinomas.
Levels of matrix metalloproteases in bladder cancer correlate with tumor grade and invasion.
Localization by in situ hybridization of mRNAs encoding stromelysin 3 and tissue inhibitors of metallo-proteinases TIMP-1 and TIMP-2 in human head and neck carcinomas.
Lysyl oxidase-like-1 enhances lung metastasis when lactate accumulation and monocarboxylate transporter expression are involved.
Mast cells and matrix metalloproteinase 9 expression in actinic cheilitis and lip squamous cell carcinoma.
Matrilysin (MMP-7) is a novel broadly expressed tumor antigen recognized by antigen-specific T cells.
Matrilysin-specific antisense oligonucleotide inhibits liver metastasis of human colon cancer cells in a nude mouse model.
Matrilysins may not predict the metastatic potential in squamous cell carcinoma of the tongue.
Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines.
Matrix metalloproteinase (MMP)-2 and MMP-9 polymorphisms and haplotypes as disease biomarkers.
Matrix metalloproteinase activity in urine of patients with renal cell carcinoma leads to degradation of extracellular matrix proteins: possible use as a screening assay.
Matrix metalloproteinase expression in basal cell carcinoma: relationship between enzyme profile and collagen fragmentation pattern.
Matrix metalloproteinase expression in normal skin associated with basal cell carcinoma and in distal skin from the same patients.
Matrix metalloproteinase expression in the recurrence of superficial low grade bladder transitional cell carcinoma.
Matrix metalloproteinase inhibitor, marimastat, decreases peritoneal spread of gastric carcinoma in nude mice.
Matrix metalloproteinase pharmacogenomics in non-small-cell lung carcinoma.
Matrix metalloproteinase variants associated with risk and clinical outcome of esophageal cancer.
Matrix metalloproteinase-2 and -9 activities correlate with the disease-free survival of oral squamous cell carcinoma patients.
Matrix metalloproteinase-7 activates heparin-binding epidermal growth factor-like growth factor in cutaneous squamous cell carcinoma.
Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion.
Matrix metalloproteinases (MMP), EMMPRIN (extracellular matrix metalloproteinase inducer) and mitogen-activated protein kinases (MAPK): co-expression in metastatic serous ovarian carcinoma.
Membrane type 1 matrix metalloproteinase-mediated stromal syndecan-1 shedding stimulates breast carcinoma cell proliferation.
Membrane type I-matrix metalloproteinase-mediated degradation of type I collagen by oral squamous cell carcinoma cells.
MMP-13 expression in keratocyst odontogenic tumour associated with NBCCS and sporadic keratocysts.
MMP-7, MMP-8, and MMP-9 in oral and cutaneous squamous cell carcinomas.
MMPs, TIMP-2, and TGF-beta1 in the cancerization of oral lichen planus.
Modulation of uPA, MMPs and their inhibitors by a novel nutrient mixture in human colorectal, pancreatic and hepatic carcinoma cell lines.
Molecular docking of alkaloid compounds with the matrix metalloproteinase 2.
Mouse keratinocytes immortalized with large T antigen acquire alpha3beta1 integrin-dependent secretion of MMP-9/gelatinase B.
MT1?MMP promotes the proliferation and invasion of gastric carcinoma cells via regulating vimentin and E?cadherin.
MT4-MMP promotes invadopodia formation and cell motility in FaDu head and neck cancer cells.
NF-kappaB involvement in tumor-stroma interaction of squamous cell carcinoma.
Non-invasive methods of bladder cancer detection.
Notch1 signaling pathway participates in cancer invasion by regulating MMPs in lingual squamous cell carcinoma.
Overexpression of the thrombospondin 2 (TSP2) gene modulated by the matrix metalloproteinase family expression and production in human colon carcinoma cell line.
Pathobiological characteristics of intestinal and diffuse-type gastric carcinoma in Japan: an immunostaining study on the tissue microarray.
Patients with hepatic breast cancer metastases demonstrate highly specific profiles of matrix metalloproteinases MMP-2 and MMP-9 after SIRT treatment as compared to other primary and secondary liver tumours.
Phenotypes of human esophageal squamous cell carcinoma based on matrix metalloproteinase production.
Pituitary tumor-transforming 1 expression in laryngeal cancer and its association with prognosis.
PKM2 enhances cancer invasion via ETS-1-dependent induction of matrix metalloproteinase in oral squamous cell carcinoma cells.
Plasma level of tissue inhibitor of matrix metalloproteinase-1 but not that of matrix metalloproteinase-8 predicts survival in head and neck squamous cell cancer.
Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice.
Potentiation of cell invasion and matrix metalloproteinase production by alpha3beta1 integrin-mediated adhesion of gastric carcinoma cells to laminin-5.
Potentiation of tumor cell invasion by co-culture with monocytes accompanying enhanced production of matrix metalloproteinase and fibronectin.
Production of matrix metalloproteinase 9 (92-kDa gelatinase) by human oesophageal squamous cell carcinoma in response to epidermal growth factor.
Prognostic analysis of clinicopathologic factors in 49 patients with diffuse malignant peritoneal mesothelioma treated with cytoreductive surgery and intraperitoneal hyperthermic perfusion.
Prognostic impact of tissue inhibitor of matrix metalloproteinase-1 in esophageal carcinoma.
Prognostic significance of matrix metalloproteinase-20 overexpression in laryngeal squamous cell carcinoma.
Prognostic significance of the immunoexpression of matrix metalloproteinase MMP2 and its inhibitor TIMP2 in laryngeal cancer.
Prognostic significance of TIMP-2, MMP-2, and MMP-9 on high-grade serous ovarian carcinoma using digital image analysis.
Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression.
Rap1GAP promotes invasion via induction of matrix metalloproteinase 9 secretion, which is associated with poor survival in low N-stage squamous cell carcinoma.
Reduction of hyaluronan-CD44-mediated growth, migration, and cisplatin resistance in head and neck cancer due to inhibition of Rho kinase and PI-3 kinase signaling.
Reduction of in vivo tumor growth by MMI-166, a selective matrix metalloproteinase inhibitor, through inhibition of tumor angiogenesis in squamous cell carcinoma cell lines of head and neck.
Relationship among expression of basic-fibroblast growth factor, MTDH/Astrocyte elevated gene-1, adenomatous polyposis coli, matrix metalloproteinase 9,and COX-2 markers with prognostic factors in prostate carcinomas.
Relationship between the Expression of Matrix Metalloproteinase and Clinicopathologic Features in Oral Squamous Cell Carcinoma.
Requirement for matrix metalloproteinase stromelysin-3 in cell migration and apoptosis during tissue remodeling in Xenopus laevis.
Rhein suppresses matrix metalloproteinase production by regulating the Rac1/ROS/MAPK/AP-1 pathway in human ovarian carcinoma cells.
Role of the plasminogen activator and matrix metalloproteinase systems in epidermal growth factor- and scatter factor-stimulated invasion of carcinoma cells.
Selenium-induced inhibition of angiogenesis in mammary cancer at chemopreventive levels of intake.
Serum matrix metalloproteinase 8 and tissue inhibitor of metalloproteinase 1: Potential markers for malignant transformation of recurrent respiratory papillomatosis and for prognosis of laryngeal cancer.
Serum metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in lung carcinoma patients.
Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction.
Significance of matrix metalloproteinase 9 and CD34 expressions in esophageal carcinoma: correlation with DNA content.
Significance of matrix metalloproteinases and tissue inhibitors of metalloproteinase expression in the recurrence of superficial transitional cell carcinoma of the bladder.
Soluble EMMPRIN (extra-cellular matrix metalloproteinase inducer) stimulates the migration of HEp-2 human laryngeal carcinoma cells, accompanied by increased MMP-2 production in fibroblasts.
Strobilanthes crispus inhibits migration, invasion and metastasis in breast cancer.
Stromelysin 3: an independent prognostic factor for relapse-free survival in node-positive breast cancer and demonstration of novel breast carcinoma cell expression.
Stromelysin-3 expression in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans: comparison with factor XIIIa and CD34.
Stromelysin-3 expression promotes tumor take in nude mice.
Stromelysin-3 in stromal tissue as a control factor in breast cancer behavior.
Stromelysin-3 induction and interstitial collagenase repression by retinoic acid. Therapeutical implication of receptor-selective retinoids dissociating transactivation and AP-1-mediated transrepression.
Stromelysin-3: a potent marker for histopathologic differentiation between desmoplastic trichoepithelioma and morphealike basal cell carcinoma.
Substrate specificity of Xenopus matrix metalloproteinase stromelysin-3.
Suppressive effect of calcipotriol on the induction of matrix metalloproteinase (MMP)-9 and MMP-13 in a human squamous cell carcinoma cell line.
The clinical role of phospholipase A2 isoforms in advanced-stage ovarian carcinoma.
The effect of hypoxic microenvironment on matrix metalloproteinase expression in xenografts of human oral squamous cell carcinoma.
The expression of six biomarkers in the four most common ovarian cancers: correlation with clinicopathological parameters.
The IGF-I Receptor Can Alter the Matrix Metalloproteinase Repertoire of Tumor Cells through Transcriptional Regulation of PKC-{alpha}
The immunohistochemical characterization of MMP-2, MMP-10, TIMP-1, TIMP-2, and podoplanin in oral squamous cell carcinoma.
The inhibitory effect of matrix metalloproteinase inhibitor ONO-4817 on lymph node metastasis in tongue carcinoma.
The interplay of matrix metalloproteinase-8, transforming growth factor-?1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma.
The matrix metalloproteinase system in oral squamous cell carcinoma.
The prognostic values of matrix metalloproteinases in ovarian cancer.
The role of CD44 and matrix metalloproteinase-9 expression in predicting neck metastasis of supraglottic laryngeal carcinoma.
The role of the matrix metalloproteinase stromelysin in the progression of squamous cell carcinomas.
Tight junction protein claudin-1 enhances the invasive activity of oral squamous cell carcinoma cells by promoting cleavage of laminin-5 gamma2 chain via matrix metalloproteinase (MMP)-2 and membrane-type MMP-1.
TIMP-1 Overexpression in Lung Carcinoma Enhances Tumor Kinetics and Angiogenesis in Brain Metastasis.
Tissue inhibitors of matrix metalloproteinases 1 and 2 and matrix metalloproteinase activity in the serum and lungs of mice with lewis lung carcinoma.
Transcriptional induction of stromelysin-3 in mesodermal cells is mediated by an upstream CCAAT/enhancer-binding protein element associated with a DNase I-hypersensitive site.
Transcriptional regulation of the Xenopus laevis Stromelysin-3 gene by thyroid hormone is mediated by a DNA element in the first intron.
Trypsin-2 Enhances Carcinoma Invasion by Processing Tight Junctions and Activating ProMT1-MMP.
Tumor and salivary matrix metalloproteinase levels are strong diagnostic markers of oral squamous cell carcinoma.
Up-regulation of matrix metalloproteinase family gene involvement in ursolic acid-induced human lung non-small carcinoma cell apoptosis.
Up-regulation of matrix metalloproteinase-8 by betel quid extract and arecoline and its role in 2D motility.
Upregulated expression and activation of membrane?associated proteases in esophageal squamous cell carcinoma.
Urinary matrix metalloproteinase activity is not significantly altered in patients with renal cell carcinoma.
Vascular endothelial growth factor activating matrix metalloproteinase in ascitic fluid during peritoneal dissemination of ovarian cancer.
WNT-5A, but not matrix metalloproteinase 3 or beta-catenin protein, expression is related to early stages of lip carcinogenesis.
[An experimental study of matrix metalloproteinase inhibitor BB-94 inhibits the invasion and metastasis of the human salivary adenoid cystic carcinoma in vitro and in vivo]
[Assay of matrix metalloproteinase levels and their endogenous inhibitors in patients with laryngeal carcinoma]
[Collagenase-3 (MMP-13) expression in epithelial cancers of the eyelids]
[Correlation of membrane type I matrix metalloproteinase (MT1-MMP) expression with clinicomorphological features of tumor front in squamous cell carcinoma of the larynx]
[Detection of stromelysin mRNA expression in human hepatocellular carcinoma by in situ hybridization]
[Expression and significance of matrix metalloproteinase and tissue inhibitor of metalloproteinase in nasal cavity squamous cell carcinoma].
[Expression of extracellular matrix metalloproteinase inducer in human bladder transitional cell carcinoma]
[Expression of extracellular matrix metalloproteinase inducer in laryngeal squamous cell carcinoma]
[Expressions of CD147, MMP-2 and MMP-9 in laryngeal carcinoma and clinical significance]
[Expressions of discoidin domain receptor 1 and matrix metalloproteinase 2 in salivary gland adenoid cystic carcinoma and clinical significance].
[Inhibitory effects of matrix metalloproteinase (MMP) inhibitor LY52 on expression of MMP-2 and MMP-9 and invasive ability of human ovarian carcinoma cell line SKOV3]
[Matrix metalloproteinase 2 and 9 as the factor of head and neck tumor metastasis]
[Matrix metalloproteinase in human gastric carcinoma]
[Relationship between expression of matrix metalloproteinase (MMP-9) and tumor angiogenesis, cancer cell proliferation, invasion, and metastasis in invasive carcinoma of cervix]
[Relationship between expression of MMP-2 and prognosis in human laryngeal squamous cell carcinoma].
[Relationship of expression unbalance of matrix metalloproteinase and tissue inhibitor of metalloproteinase to invasiveness and metastasis in gastric carcinomas]
[The expression of EMMPRIN and the matrix metalloproteinase MMP-1 in the cervix uteri and corpus uteri in cervical squamous cell carcinoma].
Carcinoma, Adenoid Cystic
Extracellular matrix metalloproteinase inducer expression in salivary gland tumors: a correlation with microvessel density.
[An experimental study of matrix metalloproteinase inhibitor BB-94 inhibits the invasion and metastasis of the human salivary adenoid cystic carcinoma in vitro and in vivo]
[Expressions of discoidin domain receptor 1 and matrix metalloproteinase 2 in salivary gland adenoid cystic carcinoma and clinical significance].
Carcinoma, Basal Cell
Differential expression of matrix metalloproteinase-2 by fibroblasts in co-cultures with keratinocytes, basal cell carcinoma and melanoma.
Matrix metalloproteinase expression in basal cell carcinoma: relationship between enzyme profile and collagen fragmentation pattern.
Matrix metalloproteinase expression in normal skin associated with basal cell carcinoma and in distal skin from the same patients.
MMP-13 expression in keratocyst odontogenic tumour associated with NBCCS and sporadic keratocysts.
Stromelysin-3 expression in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans: comparison with factor XIIIa and CD34.
Carcinoma, Ductal
Intracystic papillary carcinoma of breast: interrelationship with in situ and invasive carcinoma and a proposal of pathogenesis: array comparative genomic hybridization study of 14 cases.
Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function.
Tissue inhibitor of metalloproteinase-4 is elevated in early-stage breast cancers with accelerated progression and poor clinical course.
Carcinoma, Embryonal
Three-dimensional extracellular matrix-directed cardioprogenitor differentiation: systematic modulation of a synthetic cell-responsive PEG-hydrogel.
Carcinoma, Hepatocellular
A study on angiogenesis-related matrix metalloproteinase networks in primary hepatocellular carcinoma.
Analysis of matrix metalloproteinase mRNAs expressed in hepatocellular carcinoma cell lines.
Antrodia cinnamomea Inhibits Migration in Human Hepatocellular Carcinoma Cells: The Role of ERp57 and PGK-1.
Assessing matrix metalloproteinase expression and activity in hepatocellular carcinomas.
BetaIg-h3 is involved in the HAb18G/CD147-mediated metastasis process in human hepatoma cells.
Black tea polyphenols target matrix metalloproteinases, RECK, proangiogenic molecules and histone deacetylase in a rat hepatocarcinogenesis model.
Blockade of Rho/Rho-associated coiled coil-forming kinase signaling can prevent progression of hepatocellular carcinoma in matrix metalloproteinase-dependent manner.
c-Met identifies a population of matrix metalloproteinase 9-producing monocytes in peritumoural stroma of hepatocellular carcinoma.
Caffeic acid phenethyl ester inhibits invasion and expression of matrix metalloproteinase in SK-Hep1 human hepatocellular carcinoma cells by targeting nuclear factor kappa B.
Chemotherapy-Enriched THBS2-Deficient Cancer Stem Cells Drive Hepatocarcinogenesis through Matrix Softness Induced Histone H3 Modifications.
Des-?-carboxyl prothrombin induces matrix metalloproteinase activity in hepatocellular carcinoma cells by involving the ERK1/2 MAPK signalling pathway.
Distinction of hepatocellular adenoma from hepatocellular carcinoma with and without cirrhosis using E-cadherin and matrix metalloproteinase immunohistochemistry.
Effects of matrix metalloproteinase inhibitor BB-94 on liver cancer growth and metastasis in a patient-like orthotopic model LCI-D20.
Elevated expression levels of androgen receptors and matrix metalloproteinase-2 and -9 in 30 cases of hepatocellular carcinoma compared with adjacent tissues as predictors of cancer invasion and staging.
Evaluation of serum matrix metalloproteinase (MMP)-9 to MMP-2 ratio as a biomarker in hepatocellular carcinoma.
Genistein inhibits tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells.
Halofuginone suppresses the lung metastasis of chemically induced hepatocellular carcinoma in rats through MMP inhibition.
High Mobility Group Box-1 promotes hepatocellular carcinoma progression through miR-21-mediated matrix metalloproteinase activity.
Induction of multiple matrix metalloproteinase genes in human hepatocellular carcinoma by hepatocyte growth factor via a transcription factor Ets-1.
Interactions of alpha2-HS-glycoprotein (fetuin) with MMP-3 and murine squamous cell carcinoma cells.
Involvement of matrix metalloproteinase type-3 in hepatocyte growth factor-induced invasion of human hepatocellular carcinoma cells.
Leukocyte function-associated antigen-1-dependent adhesion of rat ascites hepatoma AH66F to mesentery-derived mesothelial cells.
Lysophosphatidic acid augments human hepatocellular carcinoma cell invasion through LPA1 receptor and MMP-9 expression.
MicroRNA-491 is involved in metastasis of hepatocellular carcinoma by inhibitions of matrix metalloproteinase and epithelial to mesenchymal transition.
Morin regulates the expression of NF-kappaB-p65, COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma.
No association of MMP-7, MMP-8, and MMP-21 polymorphisms with the risk of hepatocellular carcinoma in a Chinese population.
Overexpression of Bmi-1 contributes to the invasion and metastasis of hepatocellular carcinoma by increasing the expression of matrix metalloproteinase (MMP)?2, MMP-9 and vascular endothelial growth factor via the PTEN/PI3K/Akt pathway.
Overexpression of discoidin domain receptor 1 increases the migration and invasion of hepatocellular carcinoma cells in association with matrix metalloproteinase.
Overexpression of EphA2, MMP-9, and MVD-CD34 in hepatocellular carcinoma: Implications for tumor progression and prognosis.
Plasma matrix metalloproteinase-9 (gelatinase B) in patients with hepatocellular carcinoma.
Prognostic value of serum MMP-8, -9 and TIMP-1 in patients with hepatocellular carcinoma.
Promotion of hepatocellular carcinoma metastasis through matrix metalloproteinase activation by epithelial-mesenchymal transition regulator twist1.
Reciprocal activation between MMP-8 and TGF-?1 stimulates EMT and malignant progression of hepatocellular carcinoma.
RECK expression is associated with angiogenesis and immunogenic Tumor Microenvironment in Hepatocellular Carcinoma, and is a prognostic factor for better survival.
Snail accelerates cancer invasion by upregulating MMP expression and is associated with poor prognosis of hepatocellular carcinoma.
Sorafenib inhibits migration and invasion of hepatocellular carcinoma cells through suppression of matrix metalloproteinase expression.
The role of serum response factor in hepatocellular carcinoma: An association with matrix metalloproteinase.
[Detection of stromelysin mRNA expression in human hepatocellular carcinoma by in situ hybridization]
Carcinoma, Intraductal, Noninfiltrating
Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function.
Tissue inhibitor of metalloproteinase-4 is elevated in early-stage breast cancers with accelerated progression and poor clinical course.
Carcinoma, Large Cell
Cytoplasmic and nuclear maspin expression in lung carcinomas: an immunohistochemical study using tissue microarrays.
Carcinoma, Lewis Lung
Tissue inhibitors of matrix metalloproteinases 1 and 2 and matrix metalloproteinase activity in the serum and lungs of mice with lewis lung carcinoma.
Carcinoma, Lobular
Matrix metalloproteinase-11 overexpressed in lobular carcinoma cells of the breast promotes anoikis resistance.
Carcinoma, Medullary
Expression of stromelysin-3 in medullary carcinoma of the breast.
Carcinoma, Mucoepidermoid
Comparative expression of matrix metalloproteinases in low-grade mucoepidermoid carcinoma and typical lung cancer.
Extracellular matrix metalloproteinase inducer expression in salivary gland tumors: a correlation with microvessel density.
Carcinoma, Non-Small-Cell Lung
Bcl-2 is an independent prognostic factor and adds to a biological model for predicting outcome in operable non-small cell lung cancer.
Caveolin-1 promotes an invasive phenotype and predicts poor prognosis in large cell lung carcinoma.
Changes in angiogenic growth factor levels after gefitinib treatment in non-small cell lung cancer.
Detection of circulating vascular endothelial growth factor and matrix metalloproteinase-9 in non-small cell lung cancer using Luminex multiplex technology.
Dysregulation of FURIN by prostaglandin-endoperoxide synthase 2 in lung epithelial NCI-H292 cells.
Expression and clinical significance of matrix metalloproteinase (MMP)-26 protein in non-small cell lung cancer.
Expression of a novel matrix metalloproteinase regulator, RECK, and its clinical significance in resected non-small cell lung cancer.
Expression of metastasis-associated molecules in non-small cell lung cancer and their prognostic significance.
Expression of mRNA MMP-7 and mRNA TIMP-1 in non-small cell lung cancer.
IL-6 regulates MMP-10 expression via JAK2/STAT3 signaling pathway in a human lung adenocarcinoma cell line.
Increased expression of matrix metalloproteinase-2 (MMP-2) predicts tumour recurrence and unfavourable outcome in non-small cell lung cancer.
Matrix metalloproteinase pharmacogenomics in non-small-cell lung carcinoma.
Matrix metalloproteinase polymorphisms and survival in stage I non-small cell lung cancer.
Negative correlation of cytoplasm TIMP3 with miR-222 indicates a good prognosis for NSCLC.
Non-invasive profiling of protease-specific elastin turnover in lung cancer: biomarker potential.
Overexpression of matrix metalloproteinase 2 predicts unfavorable outcome in early-stage non-small cell lung cancer.
Phase I trial of the matrix metalloproteinase inhibitor marimastat combined with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer.
Pretreatment vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) serum levels in patients with metastatic non-small cell lung cancer (NSCLC).
Prognostic impact of MMP-2 and MMP-9 expression in pathologic stage IA non-small cell lung cancer.
Randomized phase II feasibility study of combining the matrix metalloproteinase inhibitor BMS-275291 with paclitaxel plus carboplatin in advanced non-small cell lung cancer.
Role of serum vascular endothelial growth factor in the prediction of angiogenesis and prognosis for non-small cell lung cancer.
Serum metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in lung carcinoma patients.
Study on Invadopodia Formation for Lung Carcinoma Invasion with a Microfluidic 3D Culture Device.
Video-assisted thoracic surgery lobectomy for lung cancer is associated with less immunochemokine disturbances than thoracotomy.
[Expression and significance of MIF and CD147 in non-small cell lung cancer]
[Expression of adiponectin in non-small cell lung cancer and its relationship with MMP-9 and angiogenesis].
Carcinoma, Ovarian Epithelial
Carboxyterminal telopeptide of type I collagen (ICTP) in predicting prognosis in epithelial ovarian cancer.
Expression and correlation of CD44v6, vascular endothelial growth factor, matrix metalloproteinase-2, and matrix metalloproteinase-9 in Krukenberg tumor.
Extracellular matrix metalloproteinase inducer (EMMPRIN) expression correlates positively with active angiogenesis and negatively with basic fibroblast growth factor expression in epithelial ovarian cancer.
Matrix metalloproteinase-1 promoter polymorphism and epithelial ovarian cancer: does ethnicity matter?
Prognostic Significance of Extracellular Matrix Metalloproteinase Inducer and Matrix Metalloproteinase 2 in Epithelial Ovarian Cancer.
Prognostic significance of matrix metalloproteinase-7 in epithelial ovarian cancer and its relation to beta-catenin expression.
Carcinoma, Papillary
Intracystic papillary carcinoma of breast: interrelationship with in situ and invasive carcinoma and a proposal of pathogenesis: array comparative genomic hybridization study of 14 cases.
Carcinoma, Renal Cell
Annexin A1 expression is correlated with malignant potential of renal cell carcinoma.
Association of a haplotype of matrix metalloproteinase (MMP)-1 and MMP-3 polymorphisms with renal cell carcinoma.
Clinicopathological Significance of Matrix Metalloproteinase-2 Protein Expression in Renal Cell Carcinoma Patients.
Effect of a matrix metalloproteinase inhibitor (ONO-4817) on lung metastasis of murine renal cell carcinoma.
Epidermal growth factor (EGF) increases the in vitro invasion, motility and adhesion interactions of the primary renal carcinoma cell line, A704.
Expression of matrix metalloproteinase-10 in renal cell carcinoma and its prognostic role.
Immunohistochemical expression of CD44, matrix metalloproteinase2 and matrix metalloproteinase9 in renal cell carcinomas.
Inducing regulated necrosis and shifting macrophage polarization with anti-EMMPRIN antibody (161-pAb) and complement factors.
Matrilysin (MMP-7) is a novel broadly expressed tumor antigen recognized by antigen-specific T cells.
Matrix metalloproteinase activity in urine of patients with renal cell carcinoma leads to degradation of extracellular matrix proteins: possible use as a screening assay.
Modifications of the radiosensitivity of a renal cancer cell line as a consequence of stable TIMP-1 overexpression.
PAR-type thrombin receptors in renal carcinoma cells: PAR1-mediated EGFR activation promotes cell migration.
Prognostic Role of Matrix Metalloproteinases 2, 7, 8, 9 and Their Type 1 Tissue Inhibitor in Blood Serum of Patients with Kidney Cancer.
The Contribution of MMP-7 Promoter Polymorphisms in Renal Cell Carcinoma.
Urinary matrix metalloproteinase activity is not significantly altered in patients with renal cell carcinoma.
Carcinoma, Small Cell
Cytoplasmic and nuclear maspin expression in lung carcinomas: an immunohistochemical study using tissue microarrays.
Carcinoma, Squamous Cell
A synthetic matrix metalloproteinase inhibitor prevents squamous carcinoma cell proliferation by interfering with epidermal growth factor receptor autocrine loops.
Alpha-mangostin suppresses MMP-2 and MMP-9 expression in head and neck squamous carcinoma cells.
Anticancer Efficacy of Polyphenols and Their Combinations.
Association of matrix metalloproteinase (MMP)-1 promoter polymorphism with head and neck squamous cell carcinoma.
Circulating 92-kilodalton matrix metalloproteinase (MMP-9) activity is enhanced in the euglobulin plasma fraction of head and neck squamous cell carcinoma.
Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas.
Correlation of matrix metalloproteinase-2, -9, tissue inhibitor-1 of matrix metalloproteinase and CD44 variant 6 in head and neck cancer metastasis.
Cytoplasmic and nuclear maspin expression in lung carcinomas: an immunohistochemical study using tissue microarrays.
Differential expression of degradome components in cutaneous squamous cell carcinomas.
Differential matrix metalloproteinase levels in adenocarcinoma and squamous cell carcinoma of the lung.
Differential modulation of proliferation, matrix metalloproteinase expression and invasion of human head and neck squamous carcinoma cells by c-erbB ligands.
Downregulation of MACC1 inhibits invasion, migration and proliferation, attenuates cisplatin resistance and induces apoptosis in tongue squamous cell carcinoma.
EMMPRIN-induced MMP-2 activation cascade in human cervical squamous cell carcinoma.
Enhanced production of matrix metalloproteinase-2 in human head and neck carcinomas is correlated with lymph node metastasis.
Expression and regulation of collagenase-2 (MMP-8) in head and neck squamous cell carcinomas.
Expression of collagenase-3 (MMP-13) and collagenase-1 (MMP-1) by transformed keratinocytes is dependent on the activity of p38 mitogen-activated protein kinase.
Expression of extracellular matrix metalloproteinase inducer and enhancement of the production of matrix metalloproteinase-1 in tongue squamous cell carcinoma.
Expression of FLJ10540 is correlated with aggressiveness of oral cavity squamous cell carcinoma by stimulating cell migration and invasion through increased FOXM1 and MMP-2 activity.
Expression of matrix metalloproteinase 1, matrix metalloproteinase 2, and matrix metalloproteinase 9 in carcinoma of the head and neck.
Expression of type IV collagen and its degrading enzymes in squamous cell carcinoma of lung.
Expressions of E-cadherin, Cortactin and MMP-9 in Pseudoepitheliomatous Hyperplasia and Squamous Cell Carcinoma of the Head and Neck: Their Relationships with Clinicopathologic Factors and Prognostic Implication.
High expression levels of nuclear factor kappa B and gelatinases in the tumorigenesis of oral squamous cell carcinoma.
Imatinib-associated matrix metalloproteinase suppression in p16-positive squamous cell carcinoma compared to HPV-negative HNSCC cells in vitro.
Immunohistochemical predictors in squamous cell carcinoma of the tongue and floor of the mouth.
Increased expression of matrix metalloproteinase-2 and 9 and human papilloma virus infection are associated with malignant transformation of sinonasal inverted papilloma.
Increased stromelysin 3 gene expression is associated with increased local invasiveness in head and neck squamous cell carcinomas.
Mast cells and matrix metalloproteinase 9 expression in actinic cheilitis and lip squamous cell carcinoma.
Matrilysins may not predict the metastatic potential in squamous cell carcinoma of the tongue.
Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines.
Matrix metalloproteinase (MMP)-2 and MMP-9 polymorphisms and haplotypes as disease biomarkers.
Matrix metalloproteinase-7 activates heparin-binding epidermal growth factor-like growth factor in cutaneous squamous cell carcinoma.
MMP-7, MMP-8, and MMP-9 in oral and cutaneous squamous cell carcinomas.
MT4-MMP promotes invadopodia formation and cell motility in FaDu head and neck cancer cells.
NF-kappaB involvement in tumor-stroma interaction of squamous cell carcinoma.
Notch1 signaling pathway participates in cancer invasion by regulating MMPs in lingual squamous cell carcinoma.
Plasma level of tissue inhibitor of matrix metalloproteinase-1 but not that of matrix metalloproteinase-8 predicts survival in head and neck squamous cell cancer.
Rap1GAP promotes invasion via induction of matrix metalloproteinase 9 secretion, which is associated with poor survival in low N-stage squamous cell carcinoma.
Reduction of hyaluronan-CD44-mediated growth, migration, and cisplatin resistance in head and neck cancer due to inhibition of Rho kinase and PI-3 kinase signaling.
Reduction of in vivo tumor growth by MMI-166, a selective matrix metalloproteinase inhibitor, through inhibition of tumor angiogenesis in squamous cell carcinoma cell lines of head and neck.
Suppressive effect of calcipotriol on the induction of matrix metalloproteinase (MMP)-9 and MMP-13 in a human squamous cell carcinoma cell line.
The interplay of matrix metalloproteinase-8, transforming growth factor-?1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma.
The prognostic value of CXCR4, MMP-2 and MMP-9 in tongue squamous carcinoma.
The role of the matrix metalloproteinase stromelysin in the progression of squamous cell carcinomas.
TWIST1 upregulates matrix metalloproteinase (MMP) genes family in esophageal squamous carcinoma cells.
WNT-5A, but not matrix metalloproteinase 3 or beta-catenin protein, expression is related to early stages of lip carcinogenesis.
[Collagenase-3 (MMP-13) expression in epithelial cancers of the eyelids]
[Correlation of membrane type I matrix metalloproteinase (MT1-MMP) expression with clinicomorphological features of tumor front in squamous cell carcinoma of the larynx]
[Expression and significance of matrix metalloproteinase and tissue inhibitor of metalloproteinase in nasal cavity squamous cell carcinoma].
[The expression of EMMPRIN and the matrix metalloproteinase MMP-1 in the cervix uteri and corpus uteri in cervical squamous cell carcinoma].
Carcinoma, Transitional Cell
Expression of metalloproteinase-2, metalloproteinase-9, and tissue inhibitor of metalloproteinase-1 in transitional cell carcinoma of upper urinary tract: correlation with tumor stage and survival.
Levels of matrix metalloproteases in bladder cancer correlate with tumor grade and invasion.
Matrix metalloproteinase expression in the recurrence of superficial low grade bladder transitional cell carcinoma.
Significance of matrix metalloproteinases and tissue inhibitors of metalloproteinase expression in the recurrence of superficial transitional cell carcinoma of the bladder.
[Expression of extracellular matrix metalloproteinase inducer in human bladder transitional cell carcinoma]
Carcinosarcoma
Walker 256 tumor cell degradation of extracellular matrices involves a latent gelatinase activated by reactive oxygen species.
Cardiomegaly
?1-Adrenergic blockers exert antioxidant effects, reduce matrix metalloproteinase activity, and improve renovascular hypertension-induced cardiac hypertrophy.
Relaxin reverses cardiac and renal fibrosis in spontaneously hypertensive rats.
Temporal changes in cardiac matrix metalloproteinase activity, oxidative stress, and TGF-? in renovascular hypertension-induced cardiac hypertrophy.
The Nuclear Factor kappaB Inhibitor Pyrrolidine Dithiocarbamate Prevents Cardiac Remodelling and Matrix Metalloproteinase-2 Up-Regulation in Renovascular Hypertension.
TRAF3IP2 Mediates Aldosterone/Salt-Induced Cardiac Hypertrophy and Fibrosis.
[Alterations in sympathoadrenal system in congestive heart failure]
Cardiomyopathies
A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers.
EMMPRIN and its ligand Cyclophilin A as novel diagnostic markers in inflammatory cardiomyopathy.
Extracellular matrix metalloproteinase inducer (CD147) and membrane type 1-matrix metalloproteinase are expressed on tissue macrophages in calcific aortic stenosis and induce transmigration in an artificial valve model.
Inhibiting matrix metalloproteinase by cell-based TIMP-3 gene transfer effectively treats acute and chronic ischemic cardiomyopathy.
Inhibition of matrix metalloproteinase activity by TIMP-1 gene transfer effectively treats ischemic cardiomyopathy.
Interrelation between Expression of ADAM 10 and MMP 9 and Synthesis of Peroxynitrite in Doxorubicin Induced Cardiomyopathy.
Post-transcriptional regulation of extracellular matrix metalloproteinase in human heart end-stage failure secondary to ischemic cardiomyopathy.
Release of matrix metalloproteinases following alcohol septal ablation in hypertrophic obstructive cardiomyopathy.
Cardiomyopathy, Dilated
Association of matrix metalloproteinase expression and left ventricular function in idiopathic dilated cardiomyopathy.
Bone marrow mesenchymal stem cells induce angiogenesis and attenuate the remodeling of diabetic cardiomyopathy.
Defects in matrix metalloproteinase inhibitory stoichiometry and selective MMP induction in patients with nonischemic or ischemic dilated cardiomyopathy.
EMMPRIN mediates beta-adrenergic receptor-stimulated matrix metalloproteinase activity in cardiac myocytes.
Expression of matrix metalloproteinase activity in idiopathic dilated cardiomyopathy: a marker of cardiac dilatation.
Immunoexpression of MMP-8, MMP-9 and TIMP-2 in dilated cardiomyopathy.
Increased matrix metalloproteinase activity and selective upregulation in LV myocardium from patients with end-stage dilated cardiomyopathy.
Inverse relationship between raft LRP1 localization and non-raft ERK1,2/MMP9 activation in idiopathic dilated cardiomyopathy: potential impact in ventricular remodeling.
Matrix metalloproteinase (MMP)-9, but not MMP-2, is involved in the development and progression of C protein-induced myocarditis and subsequent dilated cardiomyopathy.
Matrix metalloproteinase activation is an early event in doxorubicin-induced cardiotoxicity.
Matrix metalloproteinase-1, -3, and -9 gene polymorphisms and the risk of idiopathic dilated cardiomyopathy in a Chinese Han population.
Membrane-type-1 matrix metalloproteinase transcription and translation in myocardial fibroblasts from patients with normal left ventricular function and from patients with cardiomyopathy.
Structural insights into the binding of MMP9 inhibitors.
Cardiomyopathy, Hypertrophic
Impact of metalloproteinases on left ventricular remodeling and heart failure events in patients with hypertrophic cardiomyopathy.
Release of matrix metalloproteinases following alcohol septal ablation in hypertrophic obstructive cardiomyopathy.
Cardiomyopathy, Restrictive
Collagen subtypes and matrix metalloproteinase in idiopathic restrictive cardiomyopathy.
Cardiotoxicity
Matrix metalloproteinase activation is an early event in doxorubicin-induced cardiotoxicity.
Cardiovascular Diseases
Association between serum and oral matrix metalloproteinase-8 levels and periodontal health status.
Cellular fibronectin response to supervised moderate aerobic training in patients with type 2 diabetes.
Coconut oil consumption improves fat-free mass, plasma HDL-cholesterol and insulin sensitivity in healthy men with normal BMI compared to peanut oil.
Collagenase-2 (MMP-8) as a point-of-care biomarker in periodontitis and cardiovascular diseases. Therapeutic response to non-antimicrobial properties of tetracyclines.
Correlates of serum matrix metalloproteinase-8 (MMP-8) concentrations in nondiabetic subjects without cardiovascular disease.
Cubilin Single Nucleotide Polymorphism Variants are Associated with Macroangiopathy While a Matrix Metalloproteinase-9 Single Nucleotide Polymorphism Flip-Flop may Indicate Susceptibility of Diabetic Nephropathy in Type-2 Diabetic Patients.
Environmental arsenic exposure and serum matrix metalloproteinase-9.
Evidence for the involvement of matrix metalloproteinases in the cardiovascular effects produced by nicotine.
Extracellular Matrix Metalloproteinase Inducer EMMPRIN (CD147) in Cardiovascular Disease.
Genetic variability of matrix metalloproteinase genes in cardiovascular disease.
Genetic Variants Contributing to Circulating Matrix Metalloproteinase 8 Levels and Their Association With Cardiovascular Diseases: A Genome-Wide Analysis.
Genetics of ultrasonographic carotid atherosclerosis.
Genome-wide association scan identifies variants near Matrix Metalloproteinase (MMP) genes on chromosome 11q21-22 strongly associated with serum MMP-1 levels.
Hypothesis: Metalloproteinase Inhibitors Decrease Risks of Cardiovascular Disease.
Immediate Postnatal Overfeeding in Rats Programs Aortic Wall Structure Alterations and Metalloproteinases Dysregulation in Adulthood.
Increased Matrix Metalloproteinase 2 Activity in the Human Internal Mammary Artery Is Associated with Ageing, Hypertension, Diabetes and Kidney Dysfunction.
Influence of matrix metalloproteinase genotype on cardiovascular disease susceptibility and outcome.
Matrix metalloproteinase inhibitor properties of tetracyclines: Therapeutic potential in cardiovascular diseases.
Matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 predict incident cardiovascular disease events and all-cause mortality in a population-based cohort.
Matrix metalloproteinase-9: Many shades of function in cardiovascular disease.
Modulation of macrophage function and metabolism.
Nitric oxide attenuates matrix metalloproteinase-9 production by endothelial cells independent of cGMP- or NF?B-mediated mechanisms.
Orally active MMP-1 sparing ?-tetrahydropyranyl and ?-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease.
Plasma matrix metalloproteinase (MMP)-9 levels are reduced following low-calorie cranberry juice supplementation in men.
Practical implications of novel serum ELISA-assay for matrix metalloproteinase-8 in acute cardiac diagnostics.
Provitamin A carotenoids are independently associated with matrix metalloproteinase-9 in plasma samples from a general population.
Recent insights into natural product inhibitors of matrix metalloproteinases.
Reductions of circulating matrix metalloproteinase 2 and vascular endothelial growth factor levels after treatment with pegvisomant in subjects with acromegaly.
Regulation of MMP-9 by p53 in first trimester cytotrophoblastic cells.
Role of Salivary Biomarkers in Detection of Cardiovascular Diseases (CVD).
Serum matrix metalloproteinase-8 concentrations are associated with cardiovascular outcome in men.
Serum or Plasma Matrix Metalloproteinase (MMP)-9 Levels and Cardiovascular Diseases.
Serum tissue-degrading proteinases and incident cardiovascular disease events.
Taurine inhibits increased MMP-2 expression in a model of oxidative stress induced by glutathione depletion in rabbit heart.
The role of proteinases in angiogenesis, heart development, restenosis, atherosclerosis, myocardial ischemia, and stroke: insights from genetic studies.
[The role of changes of matrix metalloproteinase in cardiovascular diseases]
Carotid Artery Diseases
Association of MMP-8 promoter gene polymorphisms with carotid atherosclerosis: preliminary study.
Correlations of MMP-1, MMP-3, and MMP-12 with the degree of atherosclerosis, plaque stability and cardiovascular and cerebrovascular events.
Increased tissue factor, MMP-8, and D-dimer expression in diabetic patients with unstable advanced carotid atherosclerosis.
MMP-9 microsatellite polymorphism and susceptibility to carotid arteries atherosclerosis.
Plasma levels of matrix metalloproteinase-8 in patients with carotid atherosclerosis.
Carotid Stenosis
Neutrophil Gelatinase Associated Lipocalin (NGAL) for Identification of Unstable Plaques in Patients with Asymptomatic Carotid Stenosis.
Carpal Tunnel Syndrome
Matrix metalloproteinase genes on chromosome 11q22 and risk of carpal tunnel syndrome.
Cataract
Higher TGF-?1, TGF-?2, MMP-2 and TIMP-1 Levels in the Aqueous Humor of the Patients with Acute Primary Angle Closure.
Levels and activation of matrix metalloproteinases in aqueous humor are elevated in uveitis-related secondary glaucoma.
Matrix metalloproteinase inhibitors suppress transforming growth factor-beta-induced subcapsular cataract formation.
Matrix metalloproteinase-2 and -9 activities in the human lens epithelial cells and serum of steroid induced posterior subcapsular cataracts.
cathepsin s deficiency
Deficiency of cathepsin S attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice.
Central Nervous System Infections
CNS infection, CSF matrix metalloproteinase concentrations, and clinical/laboratory features.
Cerebral Amyloid Angiopathy
Matrix metalloproteinase 9-mediated intracerebral hemorrhage induced by cerebral amyloid angiopathy.
Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathy in vivo in transgenic mice.
Cerebral Hemorrhage
Combination therapy with liposomal neuroprotectants and tissue plasminogen activator for treatment of ischemic stroke.
Delayed matrix metalloproteinase inhibition reduces intracerebral hemorrhage after embolic stroke in rats.
Erythropoietin attenuates intracerebral hemorrhage by diminishing matrix metalloproteinases and maintaining blood-brain barrier integrity in mice.
High Serum Tissue Inhibitor of Matrix Metalloproteinase-1 Levels and Mortality in Patients with Spontaneous Intracerebral Hemorrhage.
Matrix metalloproteinase 9-mediated intracerebral hemorrhage induced by cerebral amyloid angiopathy.
Matrix metalloproteinase inhibition facilitates cell death in intracerebral hemorrhage in mouse.
Matrix metalloproteinase-9 inhibition attenuates vascular endothelial growth factor-induced intracerebral hemorrhage.
Minocycline and matrix metalloproteinase inhibition in acute intracerebral hemorrhage: a pilot study.
Timing of serum active MMP-9 and MMP-2 levels in acute and subacute phases after spontaneous intracerebral hemorrhage.
[Expression of matrix metalloproteinase MMP-9 in the plasma and hematoma fluid of intracerebral hemorrhage patients]
Cerebral Infarction
Associations between matrix metalloproteinase gene polymorphisms and the development of cerebral infarction.
Carotid thickness and atherosclerotic plaque stability, serum inflammation, serum MMP-2 and MMP-9 were associated with acute cerebral infarction.
Delayed Gelatinase Inhibition Induces Reticulon 4 Receptor Expression in the Peri-Infarct Cortex.
Inhibition of matrix metalloproteinase-9 activity by trandolapril after middle cerebral artery occlusion in rats.
Relationship between lysophosphatidic acid and matrix metalloproteinase-9 plasma concentrations and carotid atheromatous plaque stability in patients with cerebral infarction.
[Association between -1296T/C and -915A/G polymorphisms of matrix metalloproteinase inhibitor-3 gene and atherosclerotic cerebral infarction in an ethnic Han Chinese population].
Cerebral Palsy
A new anti-microbial combination prolongs the latency period, reduces acute histologic chorioamnionitis as well as funisitis, and improves neonatal outcomes in preterm PROM.
Amniotic fluid matrix metalloproteinase-8 and the development of cerebral palsy.
Chagas Disease
Increased activities of cardiac matrix metalloproteinases matrix metalloproteinase (MMP)-2 and MMP-9 are associated with mortality during the acute phase of experimental Trypanosoma cruzi infection.
Cheilitis
Mast cells and matrix metalloproteinase 9 expression in actinic cheilitis and lip squamous cell carcinoma.
WNT-5A, but not matrix metalloproteinase 3 or beta-catenin protein, expression is related to early stages of lip carcinogenesis.
Chlamydophila Infections
Upregulation of extracellular matrix metalloproteinase inducer (EMMPRIN) and gelatinases in human atherosclerosis infected with Chlamydia pneumoniae: the potential role of Chlamydia pneumoniae infection in the progression of atherosclerosis.
Cholangiocarcinoma
A matrix metalloproteinase inhibitor to treat unresectable cholangiocarcinoma.
Bioprinting of patient-derived in vitro intrahepatic cholangiocarcinoma tumor model: establishment, evaluation and anti-cancer drug testing.
Detection of serum MMP-7 and MMP-9 in cholangiocarcinoma patients: evaluation of diagnostic accuracy.
Expression of Matrix Metalloproteinase 2 and Extracellular Matrix Metalloproteinase Inducer are Unfavorable Postoperative Prognostic Factors in Intrahepatic Cholangiocarcinoma.
Expression pattern of matrix metalloproteinases in human liver.
Heteronemin Induces Anti-Proliferation in Cholangiocarcinoma Cells via Inhibiting TGF-? Pathway.
Cholera
Effect of cholera toxin and pertussis toxin on prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinase production by human monocytes.
Cholestasis
Lobe-specific heterogeneity in asymmetric dimethylarginine and matrix metalloproteinase levels in a rat model of obstructive cholestasis.
Repair after cholestatic liver injury correlates with neutrophil infiltration and matrix metalloproteinase 8 activity.
Cholestasis, Intrahepatic
Celastrol Attenuates Intrahepatic Cholestasis of Pregnancy by Inhibiting Matrix Metalloproteinases-2 and 9.
Epigallocatechin-3-gallate ameliorates intrahepatic cholestasis of pregnancy by inhibiting matrix metalloproteinase-2 and matrix metalloproteinase-9.
Resveratrol reduces matrix metalloproteinases and alleviates intrahepatic cholestasis of pregnancy in rats.
Cholesteatoma
Evaluation of significant gene expression changes in congenital and acquired cholesteatoma.
Expression of matrix metalloproteinase in cholesteatoma epithelium of patients with cholesteatoma otitis media.
Suppressive activity of vitamin D3 on matrix metalloproteinase production from cholesteatoma keratinocytes in vitro.
The localization of matrix metalloproteinases-8 and -13 in cholesteatoma, deep-meatal and post-auricular skin: a comparative analysis.
TREM-2 promotes acquired cholesteatoma-induced bone destruction by modulating TLR4 signaling pathway and osteoclasts activation.
Up-regulation of matrix metalloprotease-9 in middle ear cholesteatoma--correlations with growth factor expression in vivo?
Cholesteatoma, Middle Ear
Up-regulation of matrix metalloprotease-9 in middle ear cholesteatoma--correlations with growth factor expression in vivo?
Chondroma
Immunohistochemical analysis of matrix metalloproteinase-1, -3, and -13 in naturally occurring cartilaginous tumors of dogs.
Chondrosarcoma
AMP-activated protein kinase activation mediates CCL3-induced cell migration and matrix metalloproteinase-2 expression in human chondrosarcoma.
Antitumor effect of resveratrol on chondrosarcoma cells via phosphoinositide 3-kinase/AKT and p38 mitogen-activated protein kinase pathways.
Association between ratio of matrix metalloproteinase-1 to tissue inhibitor of metalloproteinase-1 and local recurrence, metastasis, and survival in human chondrosarcoma.
CCL2 increases MMP-9 expression and cell motility in human chondrosarcoma cells via the Ras/Raf/MEK/ERK/NF-?B signaling pathway.
CCN3 increases cell motility and MMP-13 expression in human chondrosarcoma through integrin dependent pathway.
Collagen and aggrecan degradation is blocked in interleukin-1-treated cartilage explants by an inhibitor of IkappaB kinase through suppression of metalloproteinase expression.
Collagenase-3 (MMP-13) expression in chondrosarcoma cells and its regulation by basic fibroblast growth factor.
Correlation of hypoxic signalling to histological grade and outcome in cartilage tumours.
CTGF enhances migration and MMP-13 up-regulation via alphavbeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells.
Cyr61 increases migration and MMP-13 expression via alphavbeta3 integrin, FAK, ERK and AP-1-dependent pathway in human chondrosarcoma cells.
Effect of pulsed electromagnetic field on MMP-9 and TIMP-1 levels in chondrosarcoma cells stimulated with IL-1?.
Endothelin-1 promotes MMP-13 production and migration in human chondrosarcoma cells through FAK/PI3K/Akt/mTOR pathways.
Expression of membrane type 1 matrix metalloproteinase in human articular cartilage.
HGF and c-Met interaction promotes migration in human chondrosarcoma cells.
Icariin inhibits MMP?1, MMP?3 and MMP?13 expression through MAPK pathways in IL?1??stimulated SW1353 chondrosarcoma cells.
Immunohistochemical analysis of matrix metalloproteinase-1, -3, and -13 in naturally occurring cartilaginous tumors of dogs.
Osteopontin increases migration and MMP-9 up-regulation via alphavbeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells.
Overexpression of cathepsin B and urokinase plasminogen activator is associated with increased risk of recurrence and metastasis in patients with chondrosarcoma.
Production of matrix metalloproteinases and a metalloproteinase inhibitor by swarm rat chondrosarcoma.
Resistin promotes tumor metastasis by down-regulation of miR-519d through the AMPK/p38 signaling pathway in human chondrosarcoma cells.
Spatholobus suberectus inhibits osteoclastogenesis and stimulates chondrogenesis.
The differential effects of IL-1 and TNF-alpha on proinflammatory cytokine and matrix metalloproteinase expression in human chondrosarcoma cells.
Thrombin enhanced migration and MMPs expression of human chondrosarcoma cells involves PAR receptor signaling pathway.
WISP-1 increases MMP-2 expression and cell motility in human chondrosarcoma cells.
Chordoma
Expression of matrix metalloproteinase (MMP)-1, MMP-2, MMP-9, cathepsin B, and urokinase plasminogen activator in non-skull base chordoma.
Reversion-inducing cysteine-rich protein with kazal motifs and matrix metalloproteinase-9 are prognostic markers in skull base chordomas.
Chorioamnionitis
A new anti-microbial combination prolongs the latency period, reduces acute histologic chorioamnionitis as well as funisitis, and improves neonatal outcomes in preterm PROM.
A rapid matrix metalloproteinase-8 bedside test for the detection of intraamniotic inflammation in women with preterm premature rupture of membranes.
An elevated amniotic fluid prostaglandin F2? concentration is associated with intra-amniotic inflammation/infection, and clinical and histologic chorioamnionitis, as well as impending preterm delivery in patients with preterm labor and intact membranes.
Chorioamnionitis increases matrix metalloproteinase-8 concentrations in bronchoalveolar lavage fluid from preterm babies.
Clinical chorioamnionitis at term VIII: a rapid MMP-8 test for the identification of intra-amniotic inflammation.
Comparison of rapid MMP-8 and interleukin-6 point-of-care tests to identify intra-amniotic inflammation/infection and impending preterm delivery in patients with preterm labor and intact membranes().
Detection of ureaplasmas by the polymerase chain reaction in the amniotic fluid of patients with cervical insufficiency.
Gastric fluid versus amniotic fluid analysis for the identification of intra-amniotic infection due to Ureaplasma species.
Immunomodulators plus antibiotics delay preterm delivery after experimental intraamniotic infection in a nonhuman primate model.
Performance characteristics of putative tests for subclinical chorioamnionitis.
Persistence after birth of systemic inflammation associated with umbilical cord inflammation.
Prognostic Markers for Chorioamnionitis: IL-6, TNF-?, and MMP-8 in Vaginally Obtained Amniotic Fluid.
SAR150640, a selective beta3-adrenoceptor agonist, prevents human myometrial remodelling and activation of matrix metalloproteinase in an in vitro model of chorioamnionitis.
The antenatal identification of funisitis with a rapid MMP-8 bedside test.
The frequency and clinical significance of intra-uterine infection and inflammation in patients with placenta previa and preterm labor and intact membranes.
The inflammatory milieu of amniotic fluid in acute-chorioamnionitis decreases with increasing gestational age.
The Inflammatory Milieu of Amniotic Fluid Increases with Chorio-Deciduitis Grade in Inflammation-Restricted to Choriodecidua, but Not Amnionitis, of Extra-Placental Membranes.
The involvement of human amnion in histologic chorioamnionitis is an indicator that a fetal and an intra-amniotic inflammatory response is more likely and severe: clinical implications.
The relationship between amniotic fluid matrix metalloproteinase-8 and funisitis.
The Relationship Between Matrix Metalloproteinase-8 in After Birth Oral Fluid and Acute Histologic Chorioamnionitis in Preterm Delivery.
Umbilical cord blood concentrations of IL-6, IL-8, and MMP-8 in pregnancy complicated by preterm premature rupture of the membranes and histological chorioamnionitis.
Vaginal Fluid Inflammatory Biomarkers and the Risk of Adverse Neonatal Outcomes in Women with PPROM.
[Clinical significance of matrix metalloproteinase-9/tissue inhibitors of matrix metalloproteinase -1 imbalance in maternal serum, amniotic fluid, umbilical cord serum in patients with premature rupture of the membranes]
Choriocarcinoma
The effect of serum from women with preeclampsia on JAR (trophoblast-like) cell line.
Choroidal Neovascularization
Matrix metalloproteinase (MMP) expression in experimental choroidal neovascularization.
Preventive versus treatment effect of AG3340, a potent matrix metalloproteinase inhibitor in a rat model of choroidal neovascularization.
Reduced choroidal neovascular membrane formation in matrix metalloproteinase-2-deficient mice.
Chronic Periodontitis
A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis.
Analysis of matrix metalloproteinase-8 levels in gingival crevicular fluid and whole mouth fluid among smokers and nonsmokers using enzyme-linked immune-sorbent assay and a novel chair-side test.
Association of matrix metalloproteinase (MMP)-1, 3, 9, interleukin (IL)-2, 8 and cyclooxygenase (COX)-2 gene polymorphisms with chronic periodontitis in a Chinese population.
Association of matrix metalloproteinase (MMP-1, MMP-3 and MMP-9) and cyclooxygenase-2 gene polymorphisms and their proteins with chronic periodontitis.
Associations between matrix metalloproteinase-8 and -14 and myeloperoxidase in gingival crevicular fluid from subjects with progressive chronic periodontitis: a longitudinal study.
Cellular source and tetracycline-inhibition of gingival crevicular fluid collagenase of patients with labile diabetes mellitus.
Clinical Correlates of A Lateral Flow Immunoassay Oral Risk Indicator.
Collagenase-2 (MMP-8) and collagenase-3 (MMP-13) in adult periodontitis: molecular forms and levels in gingival crevicular fluid and immunolocalisation in gingival tissue.
Diabetes may affect the expression of matrix metalloproteinases and their inhibitors more than smoking in chronic periodontitis.
Effect of 1,064-nm Nd:YAG laser therapy on GCF IL-1? and MMP-8 levels in patients with chronic periodontitis.
Effect of scaling and root planing on interleukin-1?, interleukin-8 and MMP-8 levels in gingival crevicular fluid from chronic periodontitis patients.
Effect of smoking on periodontal health.
Effectiveness of Probiotic Lozenges in Periodontal Management of Chronic Periodontitis Patients: Clinical and Immunological Study.
Effects of scaling and root planing and sub-antimicrobial dose doxycycline on oral and systemic biomarkers of disease in patients with both chronic periodontitis and coronary artery disease.
EFFECTS OF SRP AND SUB-ANTIMICROBIAL DOSE DOXYCYCLINE ON GCF LEVELS OF MMPs -8, -13 AND SERUM LEVELS OF HsCRP IN PATIENTS WITH CHRONIC PERIODONTITIS.
Effects of sub-antimicrobial dose doxycycline therapy on crevicular fluid MMP-8, and gingival tissue MMP-9, TIMP-1 and IL-6 levels in chronic periodontitis.
Evaluation of Systemic Levels of Neutrophilic Enzymes in Hypertensive Patients With Chronic Periodontitis.
Evaluation of the inhibitory effect of triphala on PMN-type matrix metalloproteinase (MMP-9).
Expression of ?-catenin and MMP-8 in gingival crevicular fluid and gingival tissue indicates the disease severity of patients with chronic periodontitis.
Expression of matrix metalloproteinases (MMP-8 and -9) in chronic periodontitis patients with and without diabetes mellitus.
GCF MMP-8 levels in smokers and non-smokers with chronic periodontitis following scaling and root planing accompanied by systemic use of flurbiprofen.
Gingival Crevicular Fluid (GCF) Matrix Metalloproteinase -8 Levels Predict Treatment Outcome Among Smoking Chronic Periodontitis Patients.
Gingival crevicular fluid collagenase-2 (MMP-8) test stick for chair-side monitoring of periodontitis.
Gingival crevicular fluid levels of MMP-8, MMP-9, TIMP-2, and MPO decrease after periodontal therapy.
Gingival crevicular fluid matrix metalloproteinase-8 levels following adjunctive use of meloxicam and initial phase of periodontal therapy.
Immunohistochemical study of neutrophil- and fibroblast-type collagenases and stromelysin-1 in adult periodontitis.
Importance of MMP-8 in Salivary and Gingival Crevicular Fluids of Periodontitis Patients.
Matrix metalloproteinase 8 (MMP8) gene polymorphisms in chronic periodontitis.
Matrix metalloproteinase gene polymorphisms in chronic periodontitis: a case-control study in the Indian population.
Matrix metalloproteinase-8 levels and elastase activities in gingival crevicular fluid from chronic adult periodontitis patients.
MMP-8-Responsive Polyethylene Glycol Hydrogel for Intraoral Drug Delivery.
Monitoring periodontal disease status in smokers and nonsmokers using a gingival crevicular fluid matrix metalloproteinase-8-specific chair-side test.
Proteolytic roles of matrix metalloproteinase (MMP)-13 during progression of chronic periodontitis: initial evidence for MMP-13/MMP-9 activation cascade.
Reduced expression of lipopolysaccharide-induced CXC chemokine in Porphyromonas gingivalis-induced experimental periodontitis in matrix metalloproteinase-8 null mice.
Relationship of collagenase and cathepsin G activity in gingival crevicular fluid.
Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis.
Salivary biomarkers: Relationship between oxidative stress and alveolar bone loss in chronic periodontitis.
Salivary IgA, Interleukin-1? and MMP-8 as Salivary Biomarkers in Chronic Periodontitis Patients.
Serum and salivary matrix metalloproteinases, neutrophil elastase, myeloperoxidase in patients with chronic or aggressive periodontitis.
Subantimicrobial dose doxycycline efficacy as a matrix metalloproteinase inhibitor in chronic periodontitis patients is enhanced when combined with a non-steroidal anti-inflammatory drug.
Tetracycline inhibition and the cellular source of collagenase in gingival crevicular fluid in different periodontal diseases. A review article.
Tetracycline inhibition identifies the cellular origin of interstitial collagenases in human periodontal diseases in vivo.
Tetracycline inhibition identifies the cellular sources of collagenase in gingival crevicular fluid in different forms of periodontal diseases.
The adjunctive effect of tenoxicam during non-surgical periodontal treatment on clinical parameters and gingival crevicular fluid levels of MMP-8 and TNF-? in patients with chronic periodontitis - randomized, double-blind clinical trial.
The effect of adjunctive low-dose doxycycline and licorice therapy on gingival crevicular fluid matrix metalloproteinase-8 levels in chronic periodontitis.
The effect of adjunctive low-dose doxycycline therapy on clinical parameters and gingival crevicular fluid matrix metalloproteinase-8 levels in chronic periodontitis.
The effect of adjunctive subantimicrobial dose doxycycline therapy on GCF EMMPRIN levels in chronic periodontitis.
The effect of subgingival controlled-release delivery of chlorhexidine chip on clinical parameters and matrix metalloproteinase-8 levels in gingival crevicular fluid.
The effects of the initial treatment phase and of adjunctive low-dose doxycycline therapy on clinical parameters and MMP-8, MMP-9, and TIMP-1 levels in the saliva and peripheral blood of patients with chronic periodontitis.
The impact of smoking on levels of chronic periodontitis-associated biomarkers.
The influence of smoking on the levels of matrix metalloproteinase-8 and periodontal parameters in smoker and nonsmoker patients with chronic periodontitis: A clinicobiochemical study.
The influence of type 2 diabetes mellitus on the expression of inflammatory mediators and tissue inhibitor of metalloproteinases-2 in human chronic periodontitis.
Whole Salivary Interleukin-6 and Matrix Metalloproteinase-8 Levels in Chronic Periodontitis Patients With and Without Prediabetes.
[Analysis of salivary protease spectrum in chronic periodontitis].
[Effect of photodynamic therapy on IL-1beta and MMP-8 in gingival crevicular fluid of chronic periodontitis.]
[Influence of periodontal therapy on serum interleukin-6 and carotid metalloproteinases in animals with chronic periodontitis associated with atherosclerosis].
[MMP-3 and MMP-8 levels in patients with chronic periodontitis before and after nonsurgical periodontal therapy].
Chronic Urticaria
Matrix metalloproteinase-9: a novel biomarker for monitoring disease activity in patients with chronic urticaria patients?
Coinfection
Expression of matrix metalloproteinases and their tissue inhibitors in the serum and cerebrospinal fluid of patients with HIV-1 infection and syphilis or neurosyphilis.
Colic
Detecting early kidney damage in horses with colic by measuring matrix metalloproteinase -9 and -2, other enzymes, urinary glucose and total proteins.
Colitis
Acrylamide exposure aggravates the development of ulcerative colitis in mice through activation of NF-?B, inflammatory cytokines, iNOS, and oxidative stress.
An orally active matrix metalloproteinase inhibitor, ONO-4817, reduces dextran sulfate sodium-induced colitis in mice.
Apigenin supplementation protects the development of dextran sulfate sodium-induced murine experimental colitis by inhibiting canonical and non-canonical inflammasome signaling pathways.
Beneficial effects of Batimastat (BB-94), a matrix metalloproteinase inhibitor, in rat experimental colitis.
Effect of methylprednisolone on the ulceration, matrix metalloproteinase distribution and eicosanoid production in a model of colitis in the rabbit.
Fumigaclavine C, an fungal metabolite, improves experimental colitis in mice via downregulating Th1 cytokine production and matrix metalloproteinase activity.
Inhibition of Plasmin Protects Against Colitis in Mice by Suppressing Matrix Metalloproteinase 9-Mediated Cytokine Release From Myeloid Cells.
Irsogladine maleate ameliorates inflammation and fibrosis in mice with chronic colitis induced by dextran sulfate sodium.
Lack of MMP10 exacerbates experimental colitis and promotes development of inflammation-associated colonic dysplasia.
Matrix metalloproteinase 9-induced increase in intestinal epithelial tight junction permeability contributes to the severity of experimental DSS colitis.
Matrix Metalloproteinase MMP-12 promotes macrophage transmigration across intestinal epithelial tight junctions and increases severity of experimental colitis.
Matrix metalloproteinase MMP9 maintains epithelial barrier function and preserves mucosal lining in colitis associated cancer.
Matrix metalloproteinase-9 regulates MUC-2 expression through its effect on goblet cell differentiation.
Notch1 Regulates the Effects of Matrix Metalloproteinase-9 on Colitis-Associated Cancer in Mice.
Role of chymase-dependent matrix metalloproteinase-9 activation in mice with dextran sodium sulfate-induced colitis.
The effect of an inhibitor of matrix metalloproteinases on colonic inflammation in a trinitrobenzenesulphonic acid rat model of inflammatory bowel disease.
Colitis, Ulcerative
Changes in MMP-2, MMP-9, inflammation, blood coagulation and intestinal mucosal permeability in patients with active ulcerative colitis.
Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease.
P081. Matrix Metalloproteinase Degraded Biglycan (BGM) and Citrullinated and MMP-degraded Vimentin (VICM) differentiates Crohn's disease from ulcerative colitis.
Protective effect of ilomastat on trinitrobenzenesulfonic acid-induced ulcerative colitis in rats.
Protective role of metalloproteinase inhibitor (AE-941) on ulcerative colitis in rats.
The expression of matrix metalloproteinase matrilysin indicates the degree of inflammation in ulcerative colitis.
Colitis-Associated Neoplasms
Matrix metalloproteinase MMP9 maintains epithelial barrier function and preserves mucosal lining in colitis associated cancer.
Colonic Neoplasms
Acetylcholine-induced activation of M3 muscarinic receptors stimulates robust matrix metalloproteinase gene expression in human colon cancer cells.
Administration of granulocyte colony-stimulating factor with radiotherapy promotes tumor growth by stimulating vascularization in tumor-bearing mice.
Assessment of MMP29 Gene Expression and Silver Nanoparticles Effects on Colon Cancer Cell Line (HT29).
Auraptene decreases the activity of matrix metalloproteinases in dextran sulfate sodium-induced ulcerative colitis in ICR mice.
CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix metalloproteinases.
Controlling tumor angiogenesis and metastasis of C26 murine colon adenocarcinoma by a new matrix metalloproteinase inhibitor, KB-R7785, in two tumor models.
Down-regulation of trypsinogen-2 expression by chemically modified tetracyclines: association with reduced cancer cell migration.
Downregulation of MACC1 inhibits invasion, migration and proliferation, attenuates cisplatin resistance and induces apoptosis in tongue squamous cell carcinoma.
Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells.
Effect of combination therapy with matrix metalloproteinase inhibitor MMI-166 and mitomycin C on the growth and liver metastasis of human colon cancer.
Effect of preoperative radiotherapy on matrilysin gene expression in rectal cancer.
Expression of matrix metalloproteinase matrilysin (MMP-7) was induced by activated Ki-ras via AP-1 activation in SW1417 colon cancer cells.
Gefitinib decreases the synthesis of matrix metalloproteinase and the adhesion to extracellular matrix proteins of colon cancer cells.
Inhibition of metalloproteinase and proteasome activities in colon cancer cells by citrus peel extracts.
Integrin alpha(v)beta6-associated ERK2 mediates MMP-9 secretion in colon cancer cells.
Keeping Out the Bad Guys: Gateway to Cellular Target Therapy.
Lithocholic acid and sulphated lithocholic acid differ in the ability to promote matrix metalloproteinase secretion in the human colon cancer cell line CaCo-2.
Matrix metalloproteinase inhibition prevents colon cancer peritoneal carcinomatosis development and prolongs survival in rats.
Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice.
Matrix metalloproteinase-7 triggers the matricrine action of insulin-like growth factor-II via proteinase activity on insulin-like growth factor binding protein 2 in the extracellular matrix.
microRNA-4429-5p suppresses the malignant development of colon cancer by targeting matrix metalloproteinase 16.
Muscarinic receptor agonists stimulate matrix metalloproteinase 1-dependent invasion of human colon cancer cells.
NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7.
Plasma MMP-1 Expression as a Prognostic Factor in Colon Cancer.
Polyamine-dependent expression of the matrix metalloproteinase matrilysin in a human colon cancer-derived cell line.
Prevention of liver metastasis of human colon cancer by selective matrix metalloproteinase inhibitor MMI-166.
Retinol inhibits the invasion of retinoic acid-resistant colon cancer cells in vitro and decreases matrix metalloproteinase mRNA, protein, and activity levels.
Simultaneous determination of matrix metalloproteinase (MMP)-7, MMP-1, -3, and -13 gene expression by multiplex PCR in colorectal carcinomas.
Spectrum of matrix metalloproteinase expression in primary and metastatic colon cancer: relationship to the tissue inhibitors of metalloproteinases and membrane type-1-matrix metalloproteinase.
Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial?mesenchymal transition mediated by the FAK/AKT/MMPs axis.
Synthetic matrix metalloproteinase inhibitors and tissue inhibitor of metalloproteinase (TIMP)-2, but not TIMP-1, inhibit shedding of tumor necrosis factor-alpha receptors in a human colon adenocarcinoma (Colo 205) cell line.
The alpha v beta 6 integrin induces gelatinase B secretion in colon cancer cells.
The tumor-associated antigen 90K/Mac-2-binding protein secreted by human colon carcinoma cells enhances extracellular levels of promatrilysin and is a novel substrate of matrix metalloproteinases-2, -7 (matrilysin) and -9: Implications of proteolytic cleavage.
[Increased expression of extracellular matrix metalloproteinase inducer through interaction between fibroblasts and colonic cancer cells]
Colorectal Neoplasms
(-)-Epigallocatechin-3-gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK1/2 pathway in HT-29 human colorectal cancer cells.
Assessing the value of matrix metalloproteinase 9 (MMP9) in improving the appropriateness of referrals for colorectal cancer.
Association of functional polymorphisms of matrix metalloproteinase (MMP)-1 and MMP-3 genes with colorectal cancer.
Beta-catenin--a linchpin in colorectal carcinogenesis?
Betulinic acid induces apoptosis and inhibits metastasis of human colorectal cancer cells in vitro and in vivo.
Chemotherapy in colorectal cancer: new options and new challenges.
Clinical implications of matrix metalloproteinase-1, -3, -7, -9, -12, and plasminogen activator inhibitor-1 gene polymorphisms in colorectal cancer.
Clinicopathological significance of stromal variables: angiogenesis, lymphangiogenesis, inflammatory infiltration, MMP and PINCH in colorectal carcinomas.
Comparison of matrix metalloproteinase expression between primary tumors with or without liver metastasis in pancreatic and colorectal carcinomas.
Correlation of reversion-inducing cysteine-rich protein with kazal motifs (RECK) and extracellular matrix metalloproteinase inducer (EMMPRIN), with MMP-2, MMP-9, and survival in colorectal cancer.
Corrigendum to "Hypoxia-induced microRNA-590-5p promotes colorectal cancer progression by modulating matrix metalloproteinase activity" [Cancer Lett. 416 (2018) 31-41].
Detection of regional lymph node metastases in colon cancer by using RT-PCR for matrix metalloproteinase 7, matrilysin.
Dimerumic Acid Inhibits SW620 Cell Invasion by Attenuating H(2)O(2)-Mediated MMP-7 Expression via JNK/C-Jun and ERK/C-Fos Activation in an AP-1-Dependent Manner.
Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients.
EMMPRIN is associated with S100A4 and predicts patient outcome in colorectal cancer.
High extracellular matrix metalloproteinase inducer/CD147 expression is strongly and independently associated with poor prognosis in colorectal cancer.
High-serum MMP-8 levels are associated with decreased survival and systemic inflammation in colorectal cancer.
How the matrix metalloproteinase MMP14 contributes to the progression of colorectal cancer.
Hypoxia-induced microRNA-590-5p promotes colorectal cancer progression by modulating matrix metalloproteinase activity.
In vivo optical molecular imaging of matrix metalloproteinase activity following celecoxib therapy for colorectal cancer.
Inhibition of organ invasion by the matrix metalloproteinase inhibitor batimastat (BB-94) in two human colon carcinoma metastasis models.
Insight towards the conserved water mediated recognition of catalytic and structural Zn(+2) ions in human Matrix Metalloproteinase-8 enzyme: A study by MD-simulation methods.
Knockdown of lncRNA CCEPR suppresses colorectal cancer progression.
Luteolin inhibits matrix metalloproteinase 9 and 2 in azoxymethane-induced colon carcinogenesis.
Macroscopic portal vein tumor thrombi of liver metastasis from colorectal cancer.
Matrix metalloproteinase (MMP) -1, -2, -3 and -9 promoter polymorphisms in colorectal cancer.
Matrix metalloproteinase (MMP) -2, -7 and -9 promoter polymorphisms in colorectal cancer in ethnic Kashmiri population - A case-control study and a mini review.
Matrix metalloproteinase 9 -1562C/T polymorphism increased protein levels in patients with colorectal cancer in a sample from southeastern Brazil.
Matrix Metalloproteinase Responsive Nanoparticles for Synergistic Treatment of Colorectal Cancer via Simultaneous Anti-Angiogenesis and Chemotherapy.
Matrix metalloproteinase-8 rs11225395 polymorphism correlates with colorectal cancer risk and survival in a Chinese Han population: a case-control study.
Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers.
Metastatic and non-metastatic colorectal cancer (CRC) cells induce host metalloproteinase production in vivo.
Metastatic colorectal cancer cells induce matrix metalloproteinase release by human monocytes.
MMP-9 Expression after Metallic Stent Placement in Patients with Colorectal Cancer: Association with In-Stent Restenosis.
Monitoring cell endocytosis of liposomes by real-time electrical impedance spectroscopy.
No associations of a set of SNPs in the Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinase (MMP) genes with survival of colorectal cancer patients.
Plasma concentration of tissue inhibitor of matrix metalloproteinase 1 in patients with colorectal carcinoma.
Plasma gelatinase activity does not reflect disease activity after operation for colorectal cancer.
Polymorphisms of matrix metalloproteinases 1, 2, 3 and 9 and susceptibility to lung, breast and colorectal cancer in over 30,000 subjects.
Prediction of colorectal cancer relapse and survival via tissue RNA levels of matrix metalloproteinase-9.
Prognostic significance of matrix metalloproteinase expression in colorectal carcinomas.
Prognostic significance of serum MMP-8, -9, and TIMP-1 in colorectal cancer.
Prognostic values of matrix metalloproteinase family expression in human colorectal carcinoma.
Radiation induced MMP expression from rectal cancer is short lived but contributes to in vitro invasion.
Raf and PI3K are the Molecular Targets for the Anti-metastatic Effect of Luteolin.
Serum MMP-8 and TIMP-1 predict prognosis in colorectal cancer.
Serum MMP-8 levels increase in colorectal cancer and correlate with disease course and inflammatory properties of primary tumors.
Simultaneous determination of matrix metalloproteinase (MMP)-7, MMP-1, -3, and -13 gene expression by multiplex PCR in colorectal carcinomas.
The association of matrix metalloproteinase-1 genetic polymorphism (-1607 1G>2G) with colorectal cancer: a meta-analysis.
The collagenase-1 (MMP-1) gene promoter polymorphism - 1607/2G is associated with favourable prognosis in patients with colorectal cancer.
The membrane-anchored matrix metalloproteinase (MMP) regulator RECK in combination with MMP-9 serves as an informative prognostic indicator for colorectal cancer.
The plasminogen activator and matrix metalloproteinase systems in colorectal cancer: relationship to tumour pathology.
Therapeutic effect of the matrix metalloproteinase inhibitor, batimastat, in a human colorectal cancer ascites model.
Tumor associated proteases -- prognostic markers of colorectal cancer.
[Effects of tamoxifen on apoptosis and matrix metalloproteinase-7 expression in estrogen receptor beta-positive colorectal cancer cell line HT-29]
[Polymorphisms of matrix metalloproteinase (MMP)-1 and MMP-3 in colorectal cancer]
Coma
Matrix metalloproteinase-9 as a therapeutic target for the progression of fulminant liver failure with hepatic encephalopathy: A pilot study in mice.
Communicable Diseases
Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis.
Congenital Abnormalities
Histopathological changes in collagen and matrix metalloproteinase levels in articular condyle of experimental model rats with jaw deformity.
Conjunctivitis
Tear fluid concentration of mmp-8 is elevated in non-allergic eosinophilic conjunctivitis and correlates with conjunctival inflammatory cell infiltration.
Conjunctivitis, Allergic
Activation of corneal fibroblast-derived matrix metalloproteinase-2 by tryptase.
Tear levels and activity of matrix metalloproteinase (MMP)-1 and MMP-9 in vernal keratoconjunctivitis.
Contracture
A complete expression profile of matrix-degrading metalloproteinases in Dupuytren's disease.
Apelin-induced cardioprotection against ischaemia/reperfusion injury: roles of epidermal growth factor and Src.
Corneal Injuries
Altered expression of matrix metalloproteinases and their tissue inhibitors as possible contributors to corneal droplet formation in climatic droplet keratopathy.
Tear levels and activity of matrix metalloproteinase (MMP)-1 and MMP-9 in vernal keratoconjunctivitis.
Corneal Neovascularization
Role of senescent fibroblasts on alkali-induced corneal neovascularization.
[Inhibitory effects of matrix metalloproteinase inhibitor on corneal neovascularization]
Corneal Opacity
An intact complement system dampens cornea inflammation during acute primary HSV-1 infection.
Corneal Ulcer
Profiles of matrix metalloproteinase activity in equine tear fluid during corneal healing in 10 horses with ulcerative keratitis.
Coronary Aneurysm
Cell distribution differences of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in patients with kawasaki disease.
Polymorphisms in the promoter regions of MMP-2, MMP-3, MMP-9 and MMP-12 genes as determinants of aneurysmal coronary artery disease.
Coronary Artery Disease
Abnormal circulating neutrophil linked matrix metalloproteinase -9 in stable coronary artery disease.
Causal associations of serum matrix metalloproteinase-8 level with ischaemic stroke and ischaemic stroke subtypes: a Mendelian randomization study.
Correlation of oxidative stress with activity of matrix metalloproteinase in patients with coronary artery disease. Possible role for left ventricular remodelling.
Decreased plasma and cardiac matrix metalloproteinase activities in patients with coronary artery disease and treated with pravastatin.
Doxycycline Reduces Cardiac Matrix Metalloproteinase-2 Activity but Does not Ameliorate Myocardial Dysfunction During Reperfusion in Coronary Artery Bypass Patients Undergoing Cardiopulmonary Bypass.
Effects of scaling and root planing and sub-antimicrobial dose doxycycline on oral and systemic biomarkers of disease in patients with both chronic periodontitis and coronary artery disease.
Effects of simvastatin withdrawal on serum matrix metalloproteinases in hypercholesterolaemic patients.
High plasma levels of matrix metalloproteinase-8 in patients with unstable angina.
Immunoglobulin E and matrix metalloproteinase-9 in patients with different stages of coronary artery diseases.
Matrix metalloproteinase circulating levels, genetic polymorphisms, and susceptibility to acute myocardial infarction among patients with coronary artery disease.
Matrix metalloproteinase inhibition with tetracyclines for the treatment of coronary artery disease.
Matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 predict incident cardiovascular disease events and all-cause mortality in a population-based cohort.
Meta-analysis: matrix metalloproteinase family gene polymorphisms and risk for coronary artery disease.
Multiple-polymorphism associations of 7 matrix metalloproteinase and tissue inhibitor metalloproteinase genes with myocardial infarction and angiographic coronary artery disease.
Plasma EMMPRIN levels in acute myocardial infarction and stable coronary artery disease.
Plasma matrix metalloproteinase-8 concentrations are associated with the presence and severity of coronary artery disease.
Plasma neutrophil gelatinase-associated lipocalin levels are associated with the presence and severity of coronary heart disease.
Practical implications of novel serum ELISA-assay for matrix metalloproteinase-8 in acute cardiac diagnostics.
Progression of kidney disease in non-diabetic patients with coronary artery disease: predictive role of circulating matrix metalloproteinase-2, -3, and -9.
Role of matrix metalloproteinases in coronary artery disease.
The Co-Existence of the IL-18+183 A/G and MMP-9 -1562 C/T Polymorphisms Is Associated with Clinical Events in Coronary Artery Disease Patients.
The effects of nanomicelle of curcumin on the matrix metalloproteinase (MMP-2, 9) activity and expression in patients with coronary artery disease (CAD): A randomized controlled clinical trial.
Urinary levels of matrix metalloproteinase 9 and 2 and tissue inhibitor of matrix metalloproteinase in patients with coronary artery disease.
Variant in GALNT3 Gene Linked with Reduced Coronary Artery Disease Risk in Chinese Population.
[Inflammatory-destructive biomarkers of atherosclerotic plaques instability. Study of arterial wall and blood].
Coronary Disease
Can matrix metalloproteinase inhibitors provide a realistic therapy in cardiovascular medicine?
Circulating levels of soluble EMMPRIN (CD147) correlate with levels of soluble glycoprotein VI in human plasma.
Effect of matrix metalloproteinase and their inhibitors on atrial myocardial structural remodeling.
Genetic polymorphism of MMP family and coronary disease susceptibility: a meta-analysis.
Intracoronary upregulation of platelet extracellular matrix metalloproteinase inducer (CD147) in coronary disease.
Lack of an association between matrix metalloproteinase polymorphisms and coronary heart disease in a Han Chinese population.
Salivary matrix metalloproteinase-8 in patients with and without coronary heart disease may indicate an increased susceptibility to periodontal disease.
Serum matrix metalloproteinase-8 concentrations are associated with cardiovascular outcome in men.
Serum matrix metalloproteinase-8 is associated with ulceration and vascular invasion of malignant melanoma.
The Association Between Extracellular Matrix Metalloproteinase Inducer Polymorphisms and Coronary Heart Disease: A Potential Way to Predict Disease.
[Matrix metalloproteinase-1 gene -519A/G polymorphism and the risk of coronary heart disease in Northern Chinese Han population]
[Measurement peripheral blood index related to inflammation and ox-LDL, ox-LDLAb in patients with coronary heart disease and its clinical significance]
[Relationship between atherosclerotic plaque characteristics and extracellular matrix metalloproteinase inducer and urokinase-type plasminogen activator in patients with coronary artery disease].
Coronavirus Infections
Neurovirulent Murine Coronavirus JHM.SD Uses Cellular Zinc Metalloproteases for Virus Entry and Cell-Cell Fusion.
Cough
Effect of Xiaochuanping powder on the inflammatory response and airway remodeling in asthmatic rats.
COVID-19
Active matrix metalloproteinase-8 (aMMP-8) point-of-care test (POCT) in the COVID-19 pandemic.
Creutzfeldt-Jakob Syndrome
Matrix metalloproteinase profile in patients with Creuztfeldt-Jakob disease.
Crohn Disease
An Oral Rinse Active Matrix Metalloproteinase-8 Point-of-Care Immunotest May Be Less Accurate in Patients with Crohn's Disease.
Changes in matrix metalloproteinase (MMP) and tissue inhibitors of metalloproteinases (TIMP) expression profile in Crohn's disease after immunosuppressive treatment correlate with histological score and calprotectin values.
Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease.
Infliximab treatment influences the serological expression of matrix metalloproteinase (MMP)-2 and -9 in Crohn's disease.
Misbalance in type III collagen formation/degradation as a novel serological biomarker for penetrating (Montreal B3) Crohn's disease.
P081. Matrix Metalloproteinase Degraded Biglycan (BGM) and Citrullinated and MMP-degraded Vimentin (VICM) differentiates Crohn's disease from ulcerative colitis.
Ramiprilate inhibits functional matrix metalloproteinase activity in Crohn's disease fistulas.
Cryptorchidism
Plasma concentration of MMP-1 and MMP-2 in boys with cryptorchidism and its lack of correlation with INSL3 and inhibin B.
Cutis Laxa
Regulation of matrix metalloproteinase (MMP) expression in cutis laxa fibroblasts: upregulation of MMP-1, MMP-3 and MMP-9 genes but not of the MMP-2 gene.
Cystic Fibrosis
An observational study of matrix metalloproteinase (MMP)-9 in cystic fibrosis.
Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis.
Neutrophil collagenase in sputum from patients with cystic fibrosis.
Cysts
Characterization of interstitial collagenases in jaw cyst wall.
Cystic vestibular schwannomas: a possible role of matrix metalloproteinase-2 in cyst development and unfavorable surgical outcome.
Doxycycline use in patients with lymphangioleiomyomatosis: safety and efficacy in metalloproteinase blockade.
Expression of matrix metalloproteinase in the fluids of renal cystic lesions.
Increased expression of intracystic matrix metalloproteinases in brain tumors: relationship to the pathogenesis of brain tumor-associated cysts and peritumoral edema.
Novel matrix metalloproteinase from the cyst nematodes Heterodera glycines and Globodera rostochiensis.
Dementia
Impact of the matrix metalloproteinase MMP-3 on dementia.
Matrix Metalloproteinase in Blood-Brain Barrier Breakdown in Dementia.
Mononuclear phagocyte differentiation, activation, and viral infection regulate matrix metalloproteinase expression: implications for human immunodeficiency virus type 1-associated dementia.
Possible relationship between periodontitis and dementia in a North Indian old age population: a pilot study.
Demyelinating Diseases
Estrogen treatment decreases matrix metalloproteinase (MMP)-9 in autoimmune demyelinating disease through estrogen receptor alpha (ERalpha).
Matrix metalloproteinase-9 facilitates remyelination in part by processing the inhibitory NG2 proteoglycan.
Matrix metalloproteinases and their tissue inhibitors in cuprizone-induced demyelination and remyelination of brain white and gray matter.
Steroids and brain atrophy in multiple sclerosis.
Dengue
MMP cellular responses to dengue virus infection-induced vascular leakage.
Dental Caries
Dentin degradonomics - The potential role of salivary MMP-8 in dentin caries.
Effect of sealing infected dentin with glass ionomer cement on the abundance and localization of MMP-2, MMP-8, and MMP-9 in young permanent molars in vivo.
Matrix metalloproteinases (MMPs) in oral diseases.
[A preliminary study of saliva matrix metalloproteinases (MMP-2 and MMP-9) in children with caries].
Dental Plaque
Chlamydia pneumoniae together with collagenase-2 (MMP-8) in periodontal lesions.
Effect of smoking cessation for 1 year on periodontal biomarkers in gingival crevicular fluid.
Dentigerous Cyst
Comparative analysis of the immunohistochemical expression of collagen IV, MMP-9, and TIMP-2 in odontogenic cysts and tumors.
Dermatitis, Atopic
A study of matrix metalloproteinase expression and activity in atopic dermatitis using a novel skin wash sampling assay for functional biomarker analysis.
Beneficial effects of marine algal compounds in cosmeceuticals.
Dermatitis, Contact
In vivo optical imaging of matrix metalloproteinase activity detects acute and chronic contact hypersensitivity reactions and enables monitoring of the antiinflammatory effects of N-acetylcysteine.
In vivo Optical Imaging of Matrix Metalloproteinase Activity Detects Acute and Chronic Contact Hypersensitivity Reactions and Enables Monitoring of the Antiinflammatory Effects of N-Acetylcysteine.
Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response.
Diabetes Complications
Matrix metalloproteinase-2 dysregulation in type 1 diabetes.
Serum MMP-7 is increased in diabetic renal disease and diabetic diastolic dysfunction.
Diabetes Mellitus
Circulating serum matrix metalloproteinase-3 and metalloproteinase-9 are not associated with echocardiographic parameters of diastolic function in asymptomatic type 2 diabetic patients.
Crevicular fluid matrix metalloproteinase-8, -13, and TIMP-1 levels in type 2 diabetics.
Diabetes mellitus enhances vascular matrix metalloproteinase activity: role of oxidative stress.
Effect of rosiglitazone, metformin and medical nutrition treatment on arterial stiffness, serum MMP-9 and MCP-1 levels in drug naive type 2 diabetic patients.
Hyperhomocysteinemic diabetic cardiomyopathy: oxidative stress, remodeling, and endothelial-myocyte uncoupling.
Intracerebral matrix metalloproteinase 9 in fatal diabetic ketoacidosis.
Matrix metalloproteinase (MMP-2, -9) and tissue inhibitor (TIMP-1, -2) activity in tear samples of pediatric type 1 diabetic patients : MMPs in tear samples from type 1 diabetes.
Matrix metalloproteinase-8 analysis in patients with periodontal disease with prediabetes or type 2 diabetes mellitus: A systematic review.
Membrane-type matrix metalloproteinase-9 activity in placental tissue from patients with pre-existing and gestational diabetes mellitus.
Salivary matrix metalloproteinase (MMP-8) levels and gelatinase (MMP-9) activities in patients with type 2 diabetes mellitus.
Serum matrix metalloproteinase-8 is associated with ulceration and vascular invasion of malignant melanoma.
The effect of type 2 diabetes mellitus and smoking on periodontal parameters and salivary matrix metalloproteinase-8 levels.
The impact of type 2 diabetes and atorvastatin treatment on serum levels of MMP-7 and MMP-8.
The influence of type 2 diabetes mellitus on salivary matrix metalloproteinase-8 levels and periodontal parameters: A study in an Indian population.
The influence of type 2 diabetes mellitus on the expression of inflammatory mediators and tissue inhibitor of metalloproteinases-2 in human chronic periodontitis.
The Short-Term Effectiveness of Non-Surgical Treatment in Reducing Levels of Interleukin-1? and Proteases in Gingival Crevicular Fluid From Patients With Type 2 Diabetes Mellitus and Chronic Periodontitis.
The short-term effectiveness of non-surgical treatment in reducing levels of interleukin-1beta and proteases in gingival crevicular fluid from patients with type 2 diabetes mellitus and chronic periodontitis.
Diabetes Mellitus, Type 1
A close relationship between type 1 diabetes and vitamin A-deficiency and matrix metalloproteinase and hyaluronidase activities in skin tissues.
Endothelin antagonism prevents early EGFR transactivation but not increased matrix metalloproteinase activity in diabetes.
Genetic variation in the matrix metalloproteinase genes and diabetic nephropathy in type 1 diabetes.
Glycemic control prevents microvascular remodeling and increased tone in Type 2 diabetes: link to endothelin-1.
Intracerebral matrix metalloproteinase 9 in fatal diabetic ketoacidosis.
Matrix metalloproteinase (MMP-2, -9) and tissue inhibitor (TIMP-1, -2) activity in tear samples of pediatric type 1 diabetic patients : MMPs in tear samples from type 1 diabetes.
Matrix metalloproteinase -7, -8, -9 and -13 in gingival tissue of patients with type 1 diabetes and periodontitis.
Diabetes Mellitus, Type 2
A case of 14q11.2 microdeletion with autistic features, severe obesity and facial dysmorphisms suggestive of Wolf-Hirschhorn syndrome.
Circulating serum matrix metalloproteinase-3 and metalloproteinase-9 are not associated with echocardiographic parameters of diastolic function in asymptomatic type 2 diabetic patients.
Crevicular fluid matrix metalloproteinase-8, -13, and TIMP-1 levels in type 2 diabetics.
Cubilin Single Nucleotide Polymorphism Variants are Associated with Macroangiopathy While a Matrix Metalloproteinase-9 Single Nucleotide Polymorphism Flip-Flop may Indicate Susceptibility of Diabetic Nephropathy in Type-2 Diabetic Patients.
Effect of rosiglitazone, metformin and medical nutrition treatment on arterial stiffness, serum MMP-9 and MCP-1 levels in drug naive type 2 diabetic patients.
Endothelin antagonism prevents early EGFR transactivation but not increased matrix metalloproteinase activity in diabetes.
Glycemic control prevents microvascular remodeling and increased tone in Type 2 diabetes: link to endothelin-1.
Influence of Type 2 Diabetes on Prevalence of Key Periodontal Pathogens, Salivary Matrix Metalloproteinases, and Bone Remodeling Markers in Sudanese Adults with and without Chronic Periodontitis.
Low density lipoprotein from patients with Type 2 diabetes increases expression of monocyte matrix metalloproteinase and ADAM metalloproteinase genes.
Low Levels of Serum Soluble Receptors for Advanced Glycation End Products, Biomarkers for Disease State: Myth or Reality.
Matrix metalloproteinase-8 analysis in patients with periodontal disease with prediabetes or type 2 diabetes mellitus: A systematic review.
Monocyte matrix metalloproteinase production in Type 2 diabetes and controls--a cross sectional study.
Plasma matrix metalloproteinases, low density lipoprotein oxidisability and soluble adhesion molecules after a glucose load in Type 2 diabetes.
Proof of Concept: Matrix metalloproteinase inhibitor decreases inflammation and improves muscle insulin sensitivity in people with type 2 diabetes.
Salivary interleukin-6, matrix metalloproteinase-8, and osteoprotegerin in patients with periodontitis and diabetes.
Salivary matrix metalloproteinase (MMP-8) levels and gelatinase (MMP-9) activities in patients with type 2 diabetes mellitus.
The effect of type 2 diabetes mellitus and smoking on periodontal parameters and salivary matrix metalloproteinase-8 levels.
The impact of type 2 diabetes and atorvastatin treatment on serum levels of MMP-7 and MMP-8.
The influence of type 2 diabetes mellitus on salivary matrix metalloproteinase-8 levels and periodontal parameters: A study in an Indian population.
The influence of type 2 diabetes mellitus on the expression of inflammatory mediators and tissue inhibitor of metalloproteinases-2 in human chronic periodontitis.
The Short-Term Effectiveness of Non-Surgical Treatment in Reducing Levels of Interleukin-1? and Proteases in Gingival Crevicular Fluid From Patients With Type 2 Diabetes Mellitus and Chronic Periodontitis.
The short-term effectiveness of non-surgical treatment in reducing levels of interleukin-1beta and proteases in gingival crevicular fluid from patients with type 2 diabetes mellitus and chronic periodontitis.
[Polymorphisms in Genes of Cytokines and Matrix Metalloproteinases Associated With Ischemic Heart Disease in Patients With Type 2 Diabetes].
Diabetes, Gestational
Proteolytic Mediators in Gestational Diabetes Mellitus and Gingivitis.
Diabetic Cardiomyopathies
Contributions of inflammation and cardiac matrix metalloproteinase activity to cardiac failure in diabetic cardiomyopathy: the role of angiotensin type 1 receptor antagonism.
Reduced MMP-2 activity contributes to cardiac fibrosis in experimental diabetic cardiomyopathy.
Diabetic Foot
Alleviating neuropathy of diabetic foot ulcer by co-delivery of venlafaxine and matrix metalloproteinase drug-loaded cellulose nanofiber sheets: production, in vitro characterization and clinical trial.
Expression and vitamin D-mediated regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in healthy skin and in diabetic foot ulcers.
High matrix metalloproteinase levels are associated with dermal graft failure in diabetic foot ulcers.
Mechanism of action of PROMOGRAN, a protease modulating matrix, for the treatment of diabetic foot ulcers.
Nitric oxide donors selectively reduce the expression of matrix metalloproteinases-8 and -9 by human diabetic skin fibroblasts.
The role of matrix metalloproteinases in wound healing.
Diabetic Nephropathies
C-peptide exhibits a late induction effect on matrix metallopeptidase-9 in high glucose-stimulated rat mesangial cells.
Connective tissue growth factor mediates high glucose effects on matrix degradation through tissue inhibitor of matrix metalloproteinase type 1: implications for diabetic nephropathy.
Cubilin Single Nucleotide Polymorphism Variants are Associated with Macroangiopathy While a Matrix Metalloproteinase-9 Single Nucleotide Polymorphism Flip-Flop may Indicate Susceptibility of Diabetic Nephropathy in Type-2 Diabetic Patients.
Effects of glucose on matrix metalloproteinase and plasmin activities in mesangial cells: possible role in diabetic nephropathy.
Effects of mesangium glycation on matrix metalloproteinase activities: possible role in diabetic nephropathy.
Evaluation of role of doxycycline (a matrix metalloproteinase inhibitor) on renal functions in patients of diabetic nephropathy.
Genetic variation in the matrix metalloproteinase genes and diabetic nephropathy in type 1 diabetes.
Insulin-mediated activation of activator protein-1 through the mitogen-activated protein kinase pathway stimulates collagenase-1 gene transcription in the MES 13 mesangial cell line.
Periodontal Inflammatory Burden and Salivary Matrix Metalloproteinase-8 Concentration Among Patients With Chronic Kidney Disease at the Predialysis Stage.
Protective effect of Liuwei Dihuang decoction on early diabetic nephropathy induced by streptozotocin via modulating ET-ROS axis and matrix metalloproteinase activity in rats.
Study on the relationship between the methylation of the MMP-9 gene promoter region and diabetic nephropathy.
The role of megsin, a serine protease inhibitor, in diabetic mesangial matrix accumulation.
Urinary matrix metalloproteinase -8, -9, -14 and their regulators (TRY-1, TRY-2, TATI) in patients with diabetic nephropathy.
Urinary matrix metalloproteinase activity in diabetic kidney disease: a potential marker of disease progression.
Diabetic Neuropathies
Mechanistic investigations of matrix metalloproteinase-8 inhibition by metal abstraction peptide.
Diabetic Retinopathy
Correlation between angiotensin-converting enzyme, vascular endothelial growth factor, and matrix metalloproteinase-9 in the vitreous of eyes with diabetic retinopathy.
Extracellular matrix metalloproteinase inducer (EMMPRIN) is a potential biomarker of angiogenesis in proliferative diabetic retinopathy.
Human diabetic corneas preserve wound healing, basement membrane, integrin and MMP-10 differences from normal corneas in organ culture.
Investigation of Ocular Neovascularization-Related Genes and Oxidative Stress in Diabetic Rat Eye Tissues After Resveratrol Treatment.
Matrix metalloproteinase-2 dysregulation in type 1 diabetes.
Matrix metalloproteinases in human diabetic and nondiabetic vitreous.
Production and activation of matrix metalloproteinase-2 in proliferative diabetic retinopathy.
Proteinase and growth factor alterations revealed by gene microarray analysis of human diabetic corneas.
Regulation of Matrix Metalloproteinase in the Pathogenesis of Diabetic Retinopathy.
Sirt1, a negative regulator of matrix metalloproteinase-9 in diabetic retinopathy.
The activated form of gelatinase B/matrix metalloproteinase-9 is associated with diabetic vitreous hemorrhage.
Diphtheria
Acetylcholine-induced activation of M3 muscarinic receptors stimulates robust matrix metalloproteinase gene expression in human colon cancer cells.
Wound-induced HB-EGF ectodomain shedding and EGFR activation in corneal epithelial cells.
Disseminated Intravascular Coagulation
Systemic matrix metalloproteinase-8 and tissue inhibitor of metalloproteinases-1 levels in severe sepsis-associated coagulopathy.
Diverticular Diseases
Up-regulation of collagen and tissue inhibitors of matrix metalloproteinase in colonic diverticular disease.
Diverticulosis, Colonic
Genetic variants of tissue inhibitors of matrix metalloproteinase 1 (rs4898) and 2 (rs8179090) in diverticulosis.
Down Syndrome
Altered relationship between MMP-8 and TIMP-2 in gingival crevicular fluid in adolescents with Down's syndrome.
Analysis of matrix metalloproteinase (MMP-8 and MMP-2) activity in gingival crevicular fluid from children with Down's syndrome.
Characterization of matrix metalloproteinase (MMP-8 and -9) activities in the saliva and in gingival crevicular fluid of children with Down's syndrome.
Enhancement of matrix metalloproteinase (MMP)-2 activity in gingival tissue and cultured fibroblasts from Down's syndrome patients.
Dry Eye Syndromes
Chemokine receptors CCR6 and CXCR3 are necessary for CD4(+) T cell mediated ocular surface disease in experimental dry eye disease.
Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye.
EMMPRIN Modulates Epithelial Barrier Function through a MMP-Mediated Occludin Cleavage Implications in Dry Eye Disease.
Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye.
MMP-8 Is Critical for Dexamethasone Therapy in Alkali-Burned Corneas Under Dry Eye Conditions.
Therapeutic Potential of the Molecular Chaperone and Matrix Metalloproteinase Inhibitor Clusterin for Dry Eye.
Dupuytren Contracture
Dupuytren's disease and frozen shoulder induced by treatment with a matrix metalloproteinase inhibitor.
Fibroproliferative disorders and diabetes: Understanding the pathophysiologic relationship between Peyronie's disease, Dupuytren disease and diabetes.
Dyspnea
Perspectives on the value of biomarkers in acute cardiac care and implications for strategic management.
Embolic Stroke
Causal associations of serum matrix metalloproteinase-8 level with ischaemic stroke and ischaemic stroke subtypes: a Mendelian randomization study.
Delayed matrix metalloproteinase inhibition reduces intracerebral hemorrhage after embolic stroke in rats.
Matrix metalloproteinase expression after human cardioembolic stroke: temporal profile and relation to neurological impairment.
Matrix metalloproteinase expression is related to hemorrhagic transformation after cardioembolic stroke.
MMP-9-Related microRNAs as Prognostic Markers for Hemorrhagic Transformation in Cardioembolic Stroke Patients.
Serum matrix metalloproteinase-8, tissue inhibitor of metalloproteinase and myeloperoxidase in ischemic stroke.
Embolism
Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization.
The relationship between plasma MMP-1, -7, -8 and -13 levels and embolic potential during carotid endoluminal intervention.
Empyema
Matrix metalloproteinase levels in the differentiation of parapneumonic pleural effusions.
Metalloproteinases and tissue inhibitors of metalloproteinases in exudative pleural effusions.
Encephalitis
Bradykinin induces matrix metalloproteinase-9 expression and cell migration through a PKC-delta-dependent ERK/Elk-1 pathway in astrocytes.
Cerebrospinal fluid B cells correlate with early brain inflammation in multiple sclerosis.
Chemokines and matrix metalloproteinases in cerebrospinal fluid of patients with central nervous system complications caused by varicella-zoster virus.
Cytokine-mediated modulation of MMPs and TIMPs in multipotential neural precursor cells.
Doxycycline and meloxicam can treat neuroinflammation by increasing activity of antioxidant enzymes in rat brain.
Induction of matrix metalloproteinase-2 and -9 via Erk1/2-NF-?B pathway in human astroglia infected with Toxoplasma gondii.
Encephalitis, Japanese
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Encephalomyelitis
An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization.
Collagenase-2 deficiency or inhibition impairs experimental autoimmune encephalomyelitis in mice.
Expression and regulation of matrix metalloproteinase-12 in experimental autoimmune encephalomyelitis and by bone marrow derived macrophages in vitro.
Extracellular matrix metalloproteinase inducer shows active perivascular cuffs in multiple sclerosis.
Impact of Minocycline on Extracellular Matrix Metalloproteinase Inducer, a Factor Implicated in Multiple Sclerosis Immunopathogenesis.
Localization of near-infrared labeled antibodies to the central nervous system in experimental autoimmune encephalomyelitis.
Matrix metalloproteinase expression during experimental autoimmune encephalomyelitis and effects of a combined matrix metalloproteinase and tumour necrosis factor-alpha inhibitor.
Matrix metalloproteinase-12 deficiency worsens relapsing-remitting experimental autoimmune encephalomyelitis in association with cytokine and chemokine dysregulation.
MMP-2 null mice exhibit an early onset and severe experimental autoimmune encephalomyelitis due to an increase in MMP-9 expression and activity.
PEG minocycline-liposomes ameliorate CNS autoimmune disease.
Treatment of experimental autoimmune encephalomyelitis with a neurotropic alphavirus vector expressing tissue inhibitor of metalloproteinase-2.
Up-regulation of MMP-8 and MMP-9 activity in the BALB/c mouse spinal cord correlates with the severity of experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization.
Collagenase-2 deficiency or inhibition impairs experimental autoimmune encephalomyelitis in mice.
Expression and regulation of matrix metalloproteinase-12 in experimental autoimmune encephalomyelitis and by bone marrow derived macrophages in vitro.
Extracellular matrix metalloproteinase inducer shows active perivascular cuffs in multiple sclerosis.
Impact of Minocycline on Extracellular Matrix Metalloproteinase Inducer, a Factor Implicated in Multiple Sclerosis Immunopathogenesis.
Localization of near-infrared labeled antibodies to the central nervous system in experimental autoimmune encephalomyelitis.
Matrix metalloproteinase expression during experimental autoimmune encephalomyelitis and effects of a combined matrix metalloproteinase and tumour necrosis factor-alpha inhibitor.
Matrix metalloproteinase-12 deficiency worsens relapsing-remitting experimental autoimmune encephalomyelitis in association with cytokine and chemokine dysregulation.
MMP-2 null mice exhibit an early onset and severe experimental autoimmune encephalomyelitis due to an increase in MMP-9 expression and activity.
PEG minocycline-liposomes ameliorate CNS autoimmune disease.
Suppression of experimental allergic encephalomyelitis in the Lewis rat by the matrix metalloproteinase inhibitor Ro31-9790.
Treatment of experimental autoimmune encephalomyelitis with a neurotropic alphavirus vector expressing tissue inhibitor of metalloproteinase-2.
Up-regulation of MMP-8 and MMP-9 activity in the BALB/c mouse spinal cord correlates with the severity of experimental autoimmune encephalomyelitis.
Endocarditis
[Role of anti-angiogenic factor chondromodulin-I for maintaining cardiac valvular function]
Endoleak
Response of plasma matrix metalloproteinases and tissue inhibitor of metalloproteinases to stent-graft surgery for descending thoracic aortic aneurysms.
The association between plasma matrix metalloproteinase-9 concentration and endoleak after endovascular aortic aneurysm repair: a meta-analysis.
Endometrial Hyperplasia
Enhanced expressions of matrix metalloproteinase (MMP)-2 and -9 and vascular endothelial growth factors (VEGF) and increased microvascular density in the endometrial hyperplasia of women with anovulatory dysfunctional uterine bleeding.
Immunohistochemical analysis of steroid receptors, proliferation markers, apoptosis related molecules, and gelatinases in non-neoplastic and neoplastic endometrium.
Endometrial Neoplasms
Association of extracellular matrix metalloproteinase inducer in endometrial carcinoma with patient outcomes and clinicopathogenesis using monoclonal antibody 12C3.
Characterization of extracellular matrix-degrading proteinase and its inhibitor in gynecologic cancer tissues with clinically different metastatic form.
Expression of cysteine protease cathepsin L is increased in endometrial cancer and correlates with expression of growth regulatory genes.
Extracellular matrix metalloproteinase inducer and matrix metalloproteinase-2 overexpression is associated with loss of hormone receptor expression and poor prognosis in endometrial cancer.
G protein-coupled estrogen receptor-selective ligands modulate endometrial tumor growth.
Gonadotropin-releasing hormone type II (GnRH-II) agonist regulates the invasiveness of endometrial cancer cells through the GnRH-I receptor and mitogen-activated protein kinase (MAPK)-dependent activation of matrix metalloproteinase (MMP)-2.
Immunohistochemical analysis of steroid receptors, proliferation markers, apoptosis related molecules, and gelatinases in non-neoplastic and neoplastic endometrium.
Lysophosphatidic acid (LPA) effects on endometrial carcinoma in vitro proliferation, invasion, and matrix metalloproteinase activity.
Matrix metalloproteinase (MMP)-2 and MMP-9 Expression in Tumor Infiltrating CD3 Lymphocytes From Women With Endometrial Cancer.
No Association between Matrix Metalloproteinase (MMP)-1, MMP-3, and MMP-7 SNPs and Endometrial Cancer Risk.
Presence of active gelatinases in endometrial carcinoma and correlation of matrix metalloproteinase expression with increasing tumor grade and invasion.
Progestin suppresses matrix metalloproteinase production in endometrial cancer.
The association of transforming growth factor-beta 1 with myometrial invasion of endometrial carcinomas through effects on matrix metalloproteinase.
[Expression of matrix metalloproteinase-2, 9 and it's tissue inhibitor-1, 2 in endometrial carcinoma]
[The factors involved in invasive ability of endometrial carcinoma cells]
Endometriosis
Could statins constitute a novel treatment for endometriosis? Systematic review of the literature.
Differential regulation of matrix metalloproteinase-3 gene expression in endometriotic lesions compared with endometrium.
Effect of matrix metalloproteinase promoter polymorphisms on endometriosis and adenomyosis risk: evidence from a meta-analysis.
Elevated serum chemokines are independently associated with both endometriosis and uranium exposure.
Evidence for an increased release of proteolytic activity by the eutopic endometrial tissue in women with endometriosis and for involvement of matrix metalloproteinase-9.
Expression of an extracellular matrix metalloproteinase inducer (basigin) in the human ovary and ovarian endometriosis.
Expression of membrane-type 5 matrix metalloproteinase in human endometrium and endometriosis.
Expression of several components of the plasminogen activator and matrix metalloproteinase systems in endometriosis.
Extracellular matrix metalloproteinase inducer (EMMPRIN) expression in the baboon endometrium: menstrual cycle and endometriosis.
Future perspectives in the medical treatment of endometriosis.
Immunomodulators and aromatase inhibitors: are they the next generation of treatment for endometriosis?
Increased Circulating MMP-2 Levels in Infertile Patients With Moderate and Severe Pelvic Endometriosis.
Increased peritoneal and endometrial gene expression of biologically relevant cytokines and growth factors during the menstrual phase in women with endometriosis.
Increased soluble interleukin-1 receptor type II proteolysis in the endometrium of women with endometriosis.
Matrix metalloproteinase messenger RNA expression in human endometriosis grafts cultured on a chicken chorioallantoic membrane.
Matrix metalloproteinase-2, membranous type 1 matrix metalloproteinase, and tissue inhibitor of metalloproteinase-2 expression in ectopic and eutopic endometrium.
Medical treatment of endometriosis.
mRNA analysis of several components of the plasminogen activator and matrix metalloproteinase systems in endometriosis using a real-time quantitative RT-PCR assay.
Paracrine mediators of endometrial matrix metalloproteinase expression: potential targets for progestin-based treatment of endometriosis.
Paracrine regulation of matrix metalloproteinase expression in endometriosis.
Progesterone-mediated endometrial maturation limits matrix metalloproteinase (MMP) expression in an inflammatory-like environment: a regulatory system altered in endometriosis.
Steroid and cytokine regulation of matrix metalloproteinase expression in endometriosis and the establishment of experimental endometriosis in nude mice.
Steroid and growth factor regulation of matrix metalloproteinase expression and endometriosis.
Survivin gene expression in endometriosis.
Survivin, MMP-2, MT1-MMP, and TIMP-2: their impact on survival, implantation, and proliferation of endometriotic tissues.
The relevancy of the matrix metalloproteinase system to the pathophysiology of endometriosis.
[Association of matrix metalloproteinases' polymorphisms of MMP3 and MMP9 with development of genital endometriosis].
[Expression of matrix metalloproteinase and tissue inhibitor of metalloproteinase in adenomyosis]
[Expressions of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 mRNA in endometriosis]
Endotoxemia
Administration of a matrix metalloproteinase inhibitor after hemorrhage improves cardiovascular and hepatocellular function.
Effect of NOS inhibition on rat gastric matrix metalloproteinase production during endotoxemia.
Inflammation and lung injury in an ovine model of fluid resuscitated endotoxemic shock.
Inhibition of matrix metalloproteinase activity in vivo protects against vascular hyporeactivity in endotoxemia.
Matrix metalloproteinase activities are altered in the heart and plasma during endotoxemia.
Matrix metalloproteinase inhibitors attenuate endotoxemia induced cardiac dysfunction: a potential role for MMP-9.
Matrix metalloproteinase-2 proteolysis of calponin-1 contributes to vascular hypocontractility in endotoxemic rats.
Metalloproteinase inhibitor prevents hepatic injury in endotoxemic mice.
MMP-8 deficiency increases TLR/RAGE ligands S100A8 and S100A9 and exacerbates lung inflammation during endotoxemia.
MMP-8 Genotypes Influence the Inflammatory Response in Human Endotoxemia.
Simultaneous Inhibition of Tumor Necrosis Factor Receptor 1 and Matrix Metalloproteinase 8 Completely Protects Against Acute Inflammation and Sepsis.
[The activity of components of system of matrix metalloproteinase and tissue inhibitors of metalloproteinase on different stages of chronic cardiac failure].
Epidermolysis Bullosa Dystrophica
Matrix metalloproteinase-7 activates heparin-binding epidermal growth factor-like growth factor in cutaneous squamous cell carcinoma.
Epilepsy
Different circulating metalloproteinases profiles in women with migraine with and without aura.
Imbalance of matrix metalloproteinase-9 and matrix metalloproteinase tissue inhibitor-1 may contribute to hemorrhage in cerebellar arteriovenous malformations.
Important role of matrix metalloproteinase 9 in epileptogenesis.
Matrix metalloproteinase (MMP)-2 gene polymorphisms affect circulating MMP-2 levels in patients with migraine with aura.
Epiretinal Membrane
The effect of prinomastat (AG3340), a potent inhibitor of matrix metalloproteinase, on a new animal model of epiretinal membrane.
Erythema
Improvement of Skin Barrier Dysfunction by Phenolic-containing Extracts of Lycium barbarum via Nrf2/HO-1 Regulation.
Terminalia Chebulanin Attenuates Psoriatic Skin Lesion via Regulation of Heme Oxygenase-1.
Time course of lesion development in the hairless guinea-pig model of sulfur mustard-induced dermal injury.
Ultraviolet irradiation increases matrix metalloproteinase-8 protein in human skin in vivo.
Esophageal Achalasia
Gelatinase B/Matrix Metalloproteinase-9 as Innate Immune Effector Molecule in Achalasia.
Esophageal Neoplasms
Downregulation of HuR Inhibits the Progression of Esophageal Cancer through Interleukin-18.
Matrix metalloproteinase matrilysin (MMP-7) participates in the progression of human gastric and esophageal cancers.
Matrix metalloproteinase variants associated with risk and clinical outcome of esophageal cancer.
Neoadjuvant radiochemotherapy increases matrix metalloproteinase activity in healthy tissue in esophageal cancer patients.
Raf kinase inhibitor protein inhibits esophageal cancer cell invasion through downregulation of matrix metalloproteinase expression.
Ribophorin II promotes cell proliferation, migration, and invasion in esophageal cancer cells in vitro and in vivo.
Upregulated expression and activation of membrane?associated proteases in esophageal squamous cell carcinoma.
Upregulation of extracellular matrix metalloproteinase inducer promotes hypoxia-induced epithelial-mesenchymal transition in esophageal cancer.
Esophageal Squamous Cell Carcinoma
Association of functional polymorphisms in MMPs genes with gastric cardia adenocarcinoma and esophageal squamous cell carcinoma in high incidence region of North China.
Correlation of matrix metalloproteinase suppressor genes RECK, VEGF, and CD105 with angiogenesis and biological behavior in esophageal squamous cell carcinoma.
Increased matrix metalloproteinase activation in esophageal squamous cell carcinoma.
Matrix metalloproteinase variants associated with risk and clinical outcome of esophageal cancer.
Phenotypes of human esophageal squamous cell carcinoma based on matrix metalloproteinase production.
Production of matrix metalloproteinase 9 (92-kDa gelatinase) by human oesophageal squamous cell carcinoma in response to epidermal growth factor.
Upregulated expression and activation of membrane?associated proteases in esophageal squamous cell carcinoma.
Essential Hypertension
Abnormalities of the extracellular degradation of collagen type I in essential hypertension.
Family history of hypertension, anthropometric parameters and markers of early atherosclerosis in young healthy individuals.
Polymorphisms of the matrix metalloproteinase genes are associated with essential hypertension in a Caucasian population of Central Russia.
Exostoses
Evidence of genetic underexpression in chorionic villi samples of euploid fetuses with increased nuchal translucency at 10-11 weeks' gestation.
Exotropia
MMPs, TIMPs and BMP-4 in medial rectus muscle obtained from intermittent exotropia patients and their clinical correlations.
Extranodal Extension
Therapeutic effect of the matrix metalloproteinase inhibitor, batimastat, in a human colorectal cancer ascites model.
Eye Diseases
The role and function of matrix metalloproteinase-8 in rhegmatogenous retinal detachment.
Fanconi Anemia
Anticancer Efficacy of Polyphenols and Their Combinations.
Repression of matrix metalloproteinases and inhibition of cell invasion by a nutrient mixture, containing ascorbic acid, lysine, proline, and green tea extract on human fanconi anemia fibroblast cell lines.
Fasciitis
Gastroesophageal cancer, palmar fasciitis and a matrix metalloproteinase inhibitor.
Fetal Growth Retardation
Differences in Brain-Derived Neurotrophic Factor and Matrix Metalloproteinase-9 between Appropriate Neonates between Normal Birth Weight and Intrauterine Growth Restriction.
Immediate Postnatal Overfeeding in Rats Programs Aortic Wall Structure Alterations and Metalloproteinases Dysregulation in Adulthood.
Matrix metalloproteinase release from placental explants of pregnancies complicated by intrauterine growth restriction.
MiR-590-3p and its targets VEGF, PIGF, and MMP9 in early, middle, and late pregnancy: their longitudinal changes and correlations with risk of fetal growth restriction.
Presenting Twins Are Exposed to Higher Levels of Inflammatory Mediators than Nonpresenting Twins as Early as the Midtrimester of Pregnancy.
Fibroadenoma
Augmented release of matrix metalloproteinase-9 by PKC activation in organotypic cultures of human breast cancer and adjacent normal breast tissue and fibroadenoma.
Fibroma
MMP-1 and MMP-8 expression in giant-cell fibroma and inflammatory fibrous hyperplasia.
Fibromatosis, Aggressive
Matrix metalloproteinase activity modulates tumor size, cell motility, and cell invasiveness in murine aggressive fibromatosis.
Fibromatosis, Gingival
Effect of transforming growth factor-beta1, interleukin-6, and interferon-gamma on the expression of type I collagen, heat shock protein 47, matrix metalloproteinase (MMP)-1 and MMP-2 by fibroblasts from normal gingiva and hereditary gingival fibromatosis.
Fibrosarcoma
A citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cells.
A novel matrix metalloproteinase inhibitor, FYK-1388 suppresses tumor growth, metastasis and angiogenesis by human fibrosarcoma cell line.
Anti-tumor effects of Rubratoxin B on cell toxicity, inhibition of cell proliferation, cytotoxic activity and matrix metalloproteinase-2,9.
Antimetastatic activity of pinosylvin, a natural stilbenoid, is associated with the suppression of matrix metalloproteinases.
Association of suppression of extracellular signal-regulated kinase phosphorylation by epigallocatechin gallate with the reduction of matrix metalloproteinase activities in human fibrosarcoma HT1080 cells.
Characterization of Normal Murine Carpal Bone Development Prompts Re-Evaluation of Pathologic Osteolysis as the Cause of Human Carpal-Tarsal Osteolysis Disorders.
Cumulative influence of elastin peptides and plasminogen on matrix metalloproteinase activation and type I collagen invasion by HT-1080 fibrosarcoma cells.
Effect of Lapachol on the Inhibition of Matrix Metalloproteinase Related to the Invasion of Human Fibrosarcoma Cells.
Effect of phloroglucinol on oxidative stress and inflammation.
Effects of genistein on invasion and matrix metalloproteinase activities of HT1080 human fibrosarcoma cells.
Elevated sod2 activity augments matrix metalloproteinase expression: evidence for the involvement of endogenous hydrogen peroxide in regulating metastasis.
Inhibitory effects of a benz[f]indole-4,9-dione analog on cancer cell metastasis mediated by the down-regulation of matrix metalloproteinase expression in human HT1080 fibrosarcoma cells.
Inhibitory effects of caffeic acid phenethyl ester on cancer cell metastasis mediated by the down-regulation of matrix metalloproteinase expression in human HT1080 fibrosarcoma cells.
Membrane type 1 matrix metalloproteinase and gelatinase A synergistically degrade type 1 collagen in a cell model.
Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis.
Production of M2000 (?-d-mannuronic acid) and its therapeutic effect on experimental nephritis.
Radiation induced MMP expression from rectal cancer is short lived but contributes to in vitro invasion.
Remodeling of collagen matrix by human tumor cells requires activation and cell surface association of matrix metalloproteinase-2.
Resveratrol with antioxidant activity inhibits matrix metalloproteinase via modulation of SIRT1 in human fibrosarcoma cells.
Salinomycin causes migration and invasion of human fibrosarcoma cells by inducing MMP-2 expression via PI3-kinase, ERK-1/2 and p38 kinase pathways.
Stimulation of matrix metalloproteinase-9 expression in human fibrosarcoma cells by synthetic matrix metalloproteinase inhibitors.
Therapeutic approach by a novel designed anti-inflammatory drug, M2000, in experimental immune complex glomerulonephritis.
Unexpected effect of matrix metalloproteinase down-regulation on vascular intravasation and metastasis of human fibrosarcoma cells selected in vivo for high rates of dissemination.
Foot Ulcer
Alleviating neuropathy of diabetic foot ulcer by co-delivery of venlafaxine and matrix metalloproteinase drug-loaded cellulose nanofiber sheets: production, in vitro characterization and clinical trial.
Expression and vitamin D-mediated regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in healthy skin and in diabetic foot ulcers.
High matrix metalloproteinase levels are associated with dermal graft failure in diabetic foot ulcers.
Mechanism of action of PROMOGRAN, a protease modulating matrix, for the treatment of diabetic foot ulcers.
Fragile X Syndrome
Neural circuit architecture defects in a Drosophila model of Fragile X syndrome are alleviated by minocycline treatment and genetic removal of matrix metalloproteinase.
Furunculosis
Matrix metalloproteinase mRNA expression in canine anal furunculosis lesions.
Gallbladder Neoplasms
Higher risk of matrix metalloproteinase (MMP-2, 7, 9) and tissue inhibitor of metalloproteinase (TIMP-2) genetic variants to gallbladder cancer.
Nedd4L modulates the transcription of metalloproteinase-1 and -13 genes to increase the invasive activity of gallbladder cancer.
Gastritis
Assessment of systemic matrix metalloproteinase and their regulator response in children with Helicobacter pylori gastritis.
Enhanced systemic matrix metalloproteinase response in Helicobacter pylori gastritis.
Increased expression of matrix metalloproteinase-9 associated with gastric ulcer recurrence.
Transforming Growth Factor-B1 and Matrix Metalloproteinase-7 Promoter Variants Induce Risk for Helicobacter pylori-Associated Gastric Precancerous Lesions.
Gastroesophageal Reflux
Single nucleotide polymorphisms in the matrix metalloproteinase gene family and the frequency and duration of gastroesophageal reflux disease influence the risk of esophageal adenocarcinoma.
Gastrointestinal Diseases
Differential expression and processing of matrix metalloproteinase 19 marks progression of gastrointestinal diseases.
Gastrointestinal Neoplasms
Augmented anti-metastatic efficacy of a selective matrix metalloproteinase inhibitor, MMI-166, in combination with CPT-11.
CDC25A inhibition suppresses the growth and invasion of human hepatocellular carcinoma cells.
Inhibition of invasion and lymph node metastasis of gastrointestinal cancer cells by R-94138, a matrix metalloproteinase inhibitor.
Prognostic role of extracellular matrix metalloproteinase inducer/CD147 in gastrointestinal cancer: a meta-analysis of related studies.
Serum biomarkers reflecting specific tumor tissue remodeling processes are valuable diagnostic tools for lung cancer.
Short DNA sequences and bacterial DNA induce esophageal, gastric, and colorectal cancer cell invasion.
Translational research in pancreatic adenocarcinoma.
Gastrointestinal Stromal Tumors
[Correlation between expressions of matrix metalloproteinase-2 & 9 and vasculogenic mimicry in gastrointestinal stromal tumors]
Gastroschisis
Can levels of interleukins and matrix metalloproteinases in the amniotic fluid predict postnatal bowel function in fetuses with gastroschisis?
gelatinase b deficiency
Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response.
Targeted disruption of the matrix metalloproteinase-9 gene impairs smooth muscle cell migration and geometrical arterial remodeling.
Genetic Diseases, Inborn
An investigation into the MMP1 gene promoter region polymorphism--1607 2G with recessive dystrophic epidermolysis bullosa disease severity in northeastern Mexican patients.
Thoracic aortic aneurysm: reading the enemy's playbook.
Thoracic Aortic Aneurysm: Reading ttable he Enemy's Playbook.
Giant Cell Arteritis
MMP-12, a novel matrix metalloproteinase associated with giant cell arteritis.
Giant Cell Tumor of Bone
Expression and localization of extracellular matrix metalloproteinase inducer in giant cell tumor of bone.
Matrix Metalloproteinase Activity in the Stromal Cell of Giant Cell Tumor of Bone.
Transcriptional regulation of MMP-9 expression in stromal cells of human giant cell tumor of bone by tumor necrosis factor-alpha.
Giant Cell Tumors
Expression and localization of extracellular matrix metalloproteinase inducer in giant cell tumor of bone.
Matrix Metalloproteinase Activity in the Stromal Cell of Giant Cell Tumor of Bone.
Transcriptional regulation of MMP-9 expression in stromal cells of human giant cell tumor of bone by tumor necrosis factor-alpha.
Gingival Overgrowth
Gingival crevicular fluid and serum matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 levels in renal transplant patients undergoing different immunosuppressive therapy.
Quantification of matrix metalloproteinases MMP-8 and MMP-9 in gingival overgrowth.
Gingival Pocket
Levels of matrix metalloproteinases-8 and -9 with simultaneous presence of periodontal pathogens in gingival crevicular fluid as well as matrix metalloproteinase-9 and cholesterol in blood.
Salivary Matrix Metalloproteinase-8 and -9 and Myeloperoxidase in Relation to Coronary Heart and Periodontal Diseases: A Subgroup Report from the PAROKRANK Study (Periodontitis and Its Relation to Coronary Artery Disease).
Gingival Recession
Adjunctive effect of antimicrobial photodynamic therapy to nonsurgical periodontal treatment in smokers: a randomized clinical trial.
Cytokine (interleukin-1beta) and MMP levels in gingival crevicular fluid after use of platelet-rich fibrin or connective tissue graft in the treatment of localized gingival recessions.
Effects of Photodynamic Therapy on the Clinical and Gingival Crevicular Fluid Inflammatory Biomarkers in Chronic Periodontitis: A Split-Mouth Randomized Clinical Trial.
Gingivitis
A Prototype Antibody-based Biosensor for Measurement of Salivary MMP-8 in Periodontitis using Surface Acoustic Wave Technology.
Activation of neutrophil collagenase in periodontitis.
Altered relationship between MMP-8 and TIMP-2 in gingival crevicular fluid in adolescents with Down's syndrome.
Analysis of matrix metalloproteinase-8 levels in gingival crevicular fluid and whole mouth fluid among smokers and nonsmokers using enzyme-linked immune-sorbent assay and a novel chair-side test.
Biomarkers of periodontitis in oral fluids.
Characterizing the Subgingival Microbiome of Pregnant African American Women.
Decreased salivary matrix metalloproteinase-8 reflecting a defensive potential in juvenile parotitis.
Detection of gingival crevicular fluid MMP-8 levels with different laboratory and chair-side methods.
Diagnostic accuracy of a point-of-care aMMP-8 test in the discrimination of periodontal health and disease.
Diagnostic sensitivity and specificity of host-derived salivary biomarkers in periodontal disease amongst adults: Systematic review.
Elevated matrix metalloproteinase-8 in saliva and serum in polycystic ovary syndrome and association with gingival inflammation.
Evaluation of salivary biomarkers for the diagnosis of periodontitis.
Gingival crevicular fluid and serum matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 levels in renal transplant patients undergoing different immunosuppressive therapy.
Gingival crevicular fluid collagenase-2 (MMP-8) test stick for chair-side monitoring of periodontitis.
Gingival crevicular fluid MMP-8 and -13 and TIMP-1 levels in patients with rheumatoid arthritis and inflammatory periodontal disease.
Implant-safe test in patients with peri-implantitis.
Levels of myeloid-related proteins in saliva for screening and monitoring of periodontal disease.
Local and systemic levels of aMMP-8 in gingivitis and stage 3 grade C periodontitis.
Longitudinal study of salivary proteinases during pregnancy and postpartum.
Matrix metalloproteinase-1 and -8 in gingival crevicular fluid during orthodontic tooth movement: a pilot study during 1 month of follow-up after fixed appliance activation.
Matrix metalloproteinases (MMP-8 and -9) and neutrophil elastase in gingival crevicular fluid of cyclosporin-treated patients.
Oral Fluid Biomarkers for Diagnosing Gingivitis in Human: A Cross-Sectional Study.
Proteolytic Mediators in Gestational Diabetes Mellitus and Gingivitis.
Salivary and Serum Markers Related to Innate Immunity in Generalized Aggressive Periodontitis.
Salivary Biomarkers Associated with Gingivitis and Response to Therapy.
Salivary Colony Stimulating Factor-1 and Interleukin-34 in Periodontal Disease.
Salivary levels of MPO, MMP-8 and TIMP-1 are associated with gingival inflammation response patterns during experimental gingivitis.
Salivary Matrix Metalloproteinase-8 and -9 and Myeloperoxidase in Relation to Coronary Heart and Periodontal Diseases: A Subgroup Report from the PAROKRANK Study (Periodontitis and Its Relation to Coronary Artery Disease).
Targeted salivary biomarkers for discrimination of periodontal health and disease(s).
The analysis of matrix metalloproteinase-8 in gingival crevicular fluid and periodontal diseases.
The effect of adjunctive chlorhexidine mouthrinse on GCF MMP-8 and TIMP-1 levels in gingivitis: a randomized placebo-controlled study.
The effect of Parodontax® on the MMP-8 concentration in gingivitis patients.
Glaucoma
Associations between matrix metalloproteinase gene polymorphisms and glaucoma susceptibility: a meta-analysis.
Bimatoprost, latanoprost, and tafluprost induce differential expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases.
Characterisation of Ilomastat for Prolonged Ocular Drug Release.
Floppy eyelid syndrome: ocular and systemic associations.
Interleukin-20 receptor expression in the trabecular meshwork and its implication in glaucoma.
Levels and activation of matrix metalloproteinases in aqueous humor are elevated in uveitis-related secondary glaucoma.
Lycium Barbarum Exerts Protection against Glaucoma-Like Injury Via Inhibition of MMP-9 Signaling In Vitro.
Matrix metalloproteinase and cytokine expression in Tenon fibroblasts during scar formation after glaucoma filtration or implant surgery in rats.
Matrix metalloproteinase gelatinase B (MMP-9) is associated with leaking glaucoma filtering blebs.
Matrix metalloproteinase inhibition modulates postoperative scarring after experimental glaucoma filtration surgery.
Prostaglandin agonist effect on matrix metalloproteinase aqueous levels in glaucoma patients.
Safety of Using Matrix Metalloproteinase Inhibitor in Experimental Glaucoma Filtration Surgery.
Sequential Therapy with Saratin, Bevacizumab and Ilomastat to Prolong Bleb Function following Glaucoma Filtration Surgery in a Rabbit Model.
Trabodenoson on trabecular meshwork rejuvenation: a comprehensive review of clinical data.
Glaucoma, Angle-Closure
Differences in the Histopathology and Matrix Metalloproteinase Expression in Tenon's Tissue of Primary Open-Angle Glaucoma and Primary Angle-Closure Glaucoma.
Glaucoma, Open-Angle
Differences in the Histopathology and Matrix Metalloproteinase Expression in Tenon's Tissue of Primary Open-Angle Glaucoma and Primary Angle-Closure Glaucoma.
Interleukin-20 receptor expression in the trabecular meshwork and its implication in glaucoma.
Levels and activation of matrix metalloproteinases in aqueous humor are elevated in uveitis-related secondary glaucoma.
Glioblastoma
A novel one-armed anti-c-Met antibody inhibits glioblastoma growth in vivo.
Activated leukocyte cell adhesion molecule is expressed in neuroepithelial neoplasms and decreases with tumor malignancy, matrix metalloproteinase 2 expression, and absence of IDH1R132H mutation.
An Extensive Invasive Intracranial Human Glioblastoma Xenograft Model. Role of High Level Matrix Metalloproteinase 9.
BMAL1 Suppresses Proliferation, Migration, and Invasion of U87MG Cells by Downregulating Cyclin B1, Phospho-AKT, and Metalloproteinase-9.
Comparative Analysis of Matrix Metalloproteinase Family Members Reveals That MMP9 Predicts Survival and Response to Temozolomide in Patients with Primary Glioblastoma.
Concanavalin-A-induced autophagy biomarkers requires membrane type-1 matrix metalloproteinase intracellular signaling in glioblastoma cells.
Elevated levels of Mr 92,000 type IV collagenase during tumor growth in vivo.
Exogenous endothelin-1 induces cell migration and matrix metalloproteinase expression in U251 human glioblastoma multiforme.
Expression of adhesion factors and degrading proteins in primary and secondary glioblastomas and their precursor tumors.
Extracellular vesicles originating from glioblastoma cells increase metalloproteinase release by astrocytes: the role of CD147 (EMMPRIN) and ionizing radiation.
Heterogeneous regional expression patterns of matrix metalloproteinases in human malignant gliomas.
Inhibition of MMP-2 secretion from brain tumor cells suggests chemopreventive properties of a furanocoumarin glycoside and of chalcones isolated from the twigs of Dorstenia turbinata.
Ionizing radiation affects epidermal growth factor receptor signalling and metalloproteinase secretion in glioma cells.
Long Non-Coding RNA HOXA-AS2 Regulates Malignant Glioma Behaviors and Vasculogenic Mimicry Formation via the MiR-373/EGFR Axis.
Luteolin reduces migration of human glioblastoma cell lines via inhibition of the p-IGF-1R/PI3K/AKT/mTOR signaling pathway.
Mediators of glioblastoma resistance and invasion during antivascular endothelial growth factor therapy.
Phase II trial of temozolomide plus the matrix metalloproteinase inhibitor, marimastat, in recurrent and progressive glioblastoma multiforme.
Sphingosine-1-phosphate stimulates motility and invasiveness of human glioblastoma multiforme cells.
The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells.
Upregulation of tissue inhibitor of metalloproteinases (TIMP)-2 promotes matrix metalloproteinase (MMP)-2 activation and cell invasion in a human glioblastoma cell line.
Glioma
A carcinogenic trigger to study the function of tumor suppressor genes in Schmidtea mediterranea.
A complete compilation of matrix metalloproteinase expression in human malignant gliomas.
A role of matrix metalloproteinases produced by glioma-cells.
Aberrant FoxM1B expression increases matrix metalloproteinase-2 transcription and enhances the invasion of glioma cells.
Adenoviral vectors expressing fusogenic membrane glycoproteins activated via matrix metalloproteinase cleavable linkers have significant antitumor potential in the gene therapy of gliomas.
Altered actin cytoskeleton and inhibition of matrix metalloproteinase expression by vanadate and phenylarsine oxide, inhibitors of phosphotyrosine phosphatases: modulation of migration and invasion of human malignant glioma cells.
Anticancer activity of PEGylated matrix metalloproteinase cleavable peptide-conjugated adriamycin against malignant glioma cells.
ARK5 promotes glioma cell invasion, and its elevated expression is correlated with poor clinical outcome.
Bergamottin, a natural furanocoumarin abundantly present in grapefruit juice, suppresses the invasiveness of human glioma cells via inactivation of Rac1 signaling.
Cancer stem-like cells of glioblastoma characteristically express MMP-13 and display highly invasive activity.
Chlorotoxin modified morusin-PLGA nanoparticles for targeted glioblastoma therapy.
Co-expression of MMP-14 and MMP-19 predicts poor survival in human glioma.
Detection of failure of bevacizumab treatment for malignant glioma based on urinary matrix metalloproteinase activity.
Differential effects of photofrin, 5-aminolevulinic acid and calphostin C on glioma cells.
Drug-induced apoptosis by a matrix metalloproteinase inhibitor, SI-27 on human malignant glioma cell lines; in vitro study.
Effect of photodynamic therapy combined with torasemide on the expression of matrix metalloproteinase 2 and sodium-potassium-chloride cotransporter 1 in rat peritumoral edema and glioma.
Emodin suppresses hyaluronic acid-induced MMP-9 secretion and invasion of glioma cells.
Exogenous endothelin-1 induces cell migration and matrix metalloproteinase expression in U251 human glioblastoma multiforme.
Ezrin-dependent promotion of glioma cell clonogenicity, motility, and invasion mediated by BCL-2 and transforming growth factor-beta2.
Fluid shear stress regulates the invasive potential of glioma cells via modulation of migratory activity and matrix metalloproteinase expression.
Fluorescence Molecular Imaging and Tomography of Matrix Metalloproteinase-Activatable Near-Infrared Fluorescence Probe and Image-Guided Orthotopic Glioma Resection.
Functional effect of contortrostatin, a snake venom disintegrin, on human glioma cell invasion in vitro.
Glioma cell extracellular matrix metalloproteinase inducer (EMMPRIN) (CD147) stimulates production of membrane-type matrix metalloproteinases and activated gelatinase A in co-cultures with brain-derived fibroblasts.
Glycoprotein non-metastatic melanoma protein B promotes glioma motility and angiogenesis through the Wnt/?-catenin signaling pathway.
HA1077, a Rho kinase inhibitor, suppresses glioma-induced angiogenesis by targeting the Rho-ROCK and the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signal pathways.
High MMP-26 expression in glioma is correlated with poor clinical outcome of patients.
In vivo glioma growth requires host-derived matrix metalloproteinase 2 for maintenance of angioarchitecture.
Induction of matrix metalloproteinase-9 requires a polymerized actin cytoskeleton in human malignant glioma cells.
Inflammatory cytokine modulation of matrix metalloproteinase expression and invasiveness of glioma cells in a 3-dimensional collagen matrix.
Influence of bcl-2-related proteins on matrix metalloproteinase expression in a rat glioma cell line.
Inhibition of EMMPRIN by microRNA-124 suppresses the growth, invasion and tumorigenicity of gliomas.
Inhibition of glioma angiogenesis and invasion by SI-27, an anti-matrix metalloproteinase agent in a rat brain tumor model.
Injectable postoperative enzyme-responsive hydrogels for reversing temozolomide resistance and reducing local recurrence after glioma operation.
Ionizing Radiation Enhances Matrix Metalloproteinase-2 Secretion and Invasion of Glioma Cells through Src/Epidermal Growth Factor Receptor-Mediated p38/Akt and Phosphatidylinositol 3-Kinase/Akt Signaling Pathways.
Irradiation of primary human gliomas triggers dynamic and aggressive survival responses involving microvesicle signaling.
Long non-coding RNA FOXD2-AS1 promotes cell proliferation, metastasis and EMT in glioma by sponging miR-506-5p.
Long Non-Coding RNA HOXA-AS2 Regulates Malignant Glioma Behaviors and Vasculogenic Mimicry Formation via the MiR-373/EGFR Axis.
Marked inhibition of tumor growth in a malignant glioma tumor model by a novel synthetic matrix metalloproteinase inhibitor AG3340.
Matrix metalloproteinase triggered size-shrinkable gelatin-gold fabricated nanoparticles for tumor microenvironment sensitive penetration and diagnosis of glioma.
Matrix metalloproteinase-19 is highly expressed in astroglial tumors and promotes invasion of glioma cells.
Matrix metalloproteinase-2 regulates vascular patterning and growth affecting tumor cell survival and invasion in GBM.
Matrix metalloproteinases in human gliomas: activation of matrix metalloproteinase-2 (MMP-2) may be correlated with membrane-type-1 matrix metalloproteinase (MT1-MMP) expression.
MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators.
Over-expression of cyclin D1 induces glioma invasion by increasing matrix metalloproteinase activity and cell motility.
Overexpression of miR-98 inhibits cell invasion in glioma cell lines via downregulation of IKK?.
Overexpression of phospholipase D enhances matrix metalloproteinase-2 expression and glioma cell invasion via protein kinase C and protein kinase A/NF-kappaB/Sp1-mediated signaling pathways.
Phase II trial of temozolomide plus marimastat for recurrent anaplastic gliomas: A relationship among efficacy, joint toxicity and anticonvulsant status.
Phase II trial of temozolomide plus the matrix metalloproteinase inhibitor, marimastat, in recurrent and progressive glioblastoma multiforme.
PTEN gene transfer suppresses the invasive potential of human malignant gliomas by regulating cell invasion-related molecules.
Quantitative analysis of glioma cell invasion by confocal laser scanning microscopy in a novel brain slice model.
Reduction of protein kinase C delta attenuates tenascin-C stimulated glioma invasion in three-dimensional matrix.
RelB, a good prognosis predictor, links cell-cycle and migration to glioma tumorigenesis.
Remodeling of collagen matrix by human tumor cells requires activation and cell surface association of matrix metalloproteinase-2.
RNA interference?mediated knockdown of translationally controlled tumor protein induces apoptosis, and inhibits growth and invasion in glioma cells.
Role of hyaluronan in glioma invasion.
Silencing hypoxia-inducible factor-1alpha inhibits cell migration and invasion under hypoxic environment in malignant gliomas.
Simultaneous inhibition of glioma angiogenesis, cell proliferation, and invasion by a naturally occurring fragment of human metalloproteinase-2.
Suppression of cell invasion on human malignant glioma cell lines by a novel matrix-metalloproteinase inhibitor SI-27: in vitro study.
Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors.
Tanshinone IIA Suppresses Glioma Cell Proliferation, Migration and Invasion Both in vitro and in vivo Partially Through miR-16-5p/Talin-1 (TLN1) Axis.
Targeting hyaluronan interactions in spinal cord astrocytomas and diffuse pontine gliomas.
Targeting MMP-14 for dual PET and fluorescence imaging of glioma in preclinical models.
Targeting the cytotoxicity of fusogenic membrane glycoproteins in gliomas through protease-substrate interaction.
Tetraarsenic oxide-induced inhibition of malignant glioma cell invasion in vitro via a decrease in matrix metalloproteinase secretion and protein kinase B phosphorylation.
The effect of exogenous gangliosides on matrix metalloproteinase secretion by human glioma cells in vitro.
The effects of CD147 on the cell proliferation, apoptosis, invasion, and angiogenesis in glioma.
The function of MMP-28/TGF-? induced cell apoptosis in human glioma cells.
The role of matrix metalloproteinase genes in glioma invasion: co-dependent and interactive proteolysis.
The value and correlation between PRL-3 expression and matrix metalloproteinase activity and expression in human gliomas.
Tissue inhibitor of metalloproteinase-3 expression from an oncolytic adenovirus inhibits matrix metalloproteinase activity in vivo without affecting antitumor efficacy in malignant glioma.
TLR9 expression is associated with prognosis in patients with glioblastoma multiforme.
TNF-? respecifies human mesenchymal stem cells to a neural fate and promotes migration toward experimental glioma.
Glomerulonephritis
Angiotensin-converting enzyme inhibition but not angiotensin II receptor blockade regulates matrix metalloproteinase activity in patients with glomerulonephritis.
Participation of the matrix metalloproteinase inhibitor in Thy-1 nephritis.
Serum and urine markers of collagen degradation reflect renal fibrosis in experimental kidney diseases.
Gnathostomiasis
A dot-ELISA test using a Gnathostoma spinigerum recombinant matrix metalloproteinase protein for the serodiagnosis of human gnathostomiasis.
Graft vs Host Disease
A metalloproteinase inhibitor prevents acute graft-versus-host disease while preserving the graft-versus-leukaemia effect of allogeneic bone marrow transplantation.
Effect of a matrix metalloproteinase inhibitor on host resistance against Listeria monocytogenes infection.
[Prophylactic effect of matrix metalloproteinase inhibitor on acute graft-versus-host disease in a murine model]
Granuloma
A matrix metalloproteinase inhibitor promotes granuloma formation during the early phase of Mycobacterium tuberculosis pulmonary infection.
Absence of circulating aldosterone attenuates foreign body reaction around surgical sutures.
Adjunct antibody administration with standard treatment reduces relapse rates in a murine tuberculosis model of necrotic granulomas.
Cytokines, MMP-2, and MMP-9 levels in patients with a solitary cysticercus granuloma.
Improved abdominal wall wound healing by helium pneumoperitoneum.
Modulation of Matrix Metalloproteinase 14, Tissue Inhibitor of Metalloproteinase 3, Tissue Inhibitor of Metalloproteinase 4, and Inducible Nitric Oxide Synthase in the Development of Periapical Lesions.
Hajdu-Cheney Syndrome
Al-Aqeel Sewairi syndrome, a new autosomal recessive disorder with multicentric osteolysis, nodulosis and arthropathy. The first genetic defect of matrix metalloproteinase 2 gene.
Characterization of Normal Murine Carpal Bone Development Prompts Re-Evaluation of Pathologic Osteolysis as the Cause of Human Carpal-Tarsal Osteolysis Disorders.
Hantavirus Infections
Generation of plasma cells and CD27-IgD- B cells during hantavirus infection is associated with distinct pathological findings.
Head and Neck Neoplasms
Active matrix metalloproteinase-8 and interleukin-6 detect periodontal degeneration caused by radiotherapy of head and neck cancer: a pilot study.
Association of CD44 V3-containing isoforms with tumor cell growth, migration, matrix metalloproteinase expression, and lymph node metastasis in head and neck cancer.
Combined inhibition of EMMPRIN and epidermal growth factor receptor prevents the growth and migration of head and neck squamous cell carcinoma cells.
Correlation of matrix metalloproteinase-2, -9, tissue inhibitor-1 of matrix metalloproteinase and CD44 variant 6 in head and neck cancer metastasis.
Ethanolic Extract of Ocimum sanctum Leaves Reduced Invasion and Matrix Metalloproteinase Activity of Head and Neck Cancer Cell Lines.
Significant correlation of matrix metalloproteinase and macrophage colony-stimulating factor serum concentrations in patients with head and neck cancer.
The relationship between MMPs and pH in whole saliva of radiated head and neck cancer patients.
Tumor-stroma interactions influence cytokine expression and matrix metalloproteinase activities in paired primary and metastatic head and neck cancer cells.
Healthcare-Associated Pneumonia
Hospital acquired pneumonia with high-risk bacteria is associated with increased pulmonary matrix metalloproteinase activity.
Heart Arrest
Perspectives on the value of biomarkers in acute cardiac care and implications for strategic management.
Pyruvate enhances neurological recovery following cardiopulmonary arrest and resuscitation.
Serum matrix metalloproteinases in patients resuscitated from cardiac arrest. The association with therapeutic hypothermia.
[Expression of mRNA of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase after cardiopulmonary resuscitation for asphyxial cardiac arrest in rat]
Heart Defects, Congenital
Circulating matrix metalloproteinase levels after ventricular septal defect repair in infants.
Heart Diseases
Basic fibroblast growth factor inhibits ventricular remodeling in Dahl salt-sensitive hypertensive rats.
Immobilization of matrix metalloproteinase 8 (MMP-8) for online drug screening.
Matrix metalloproteinase synthesis and expression in isolated LV myocyte preparations.
Matrix metalloproteinases in the pathogenesis of viral heart disease.
Role of matrix metalloproteinases in hypertension-associated cardiac fibrosis.
Salivary matrix metalloproteinase-8 in patients with and without coronary heart disease may indicate an increased susceptibility to periodontal disease.
Short-term disruption in regional left ventricular electrical conduction patterns increases interstitial matrix metalloproteinase activity.
Heart Failure
A matrix metalloproteinase induction/activation system exists in the human left ventricular myocardium and is upregulated in heart failure.
Activation of matrix metalloproteinase dilates and decreases cardiac tensile strength.
Adrenoceptor blockade alters plasma gelatinase activity in patients with heart failure and MMP-9 promoter activity in a human cell line (ECV304).
Angiotensin-converting enzyme and matrix metalloproteinase inhibition with developing heart failure: comparative effects on left ventricular function and geometry.
Association between matrix metalloproteinase-9 and worsening heart failure events in patients with chronic heart failure.
Atorvastatin reduces myocardial fibrosis in a rat model with post-myocardial infarction heart failure by increasing the matrix metalloproteinase-2/tissue matrix metalloproteinase inhibitor-2 ratio.
Cardiac remodelling in end stage heart failure: upregulation of matrix metalloproteinase (MMP) irrespective of the underlying disease, and evidence for a direct inhibitory effect of ACE inhibitors on MMP.
Chronic doxycycline exposure accelerates left ventricular hypertrophy and progression to heart failure in mice after thoracic aorta constriction.
Clinical significance of matrix metalloproteinase (MMP)-2 in patients with acute heart failure.
Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice.
Comparison of levels of matrix metalloproteinase-2 and -3 in patients with ischemic cardiomyopathy versus nonischemic cardiomyopathy.
Contributions of inflammation and cardiac matrix metalloproteinase activity to cardiac failure in diabetic cardiomyopathy: the role of angiotensin type 1 receptor antagonism.
Correlation between serum matrix metalloproteinase and myocardial fibrosis in heart failure patients with reduced ejection fraction: A retrospective analysis.
Correlation of oxidative stress with activity of matrix metalloproteinase in patients with coronary artery disease. Possible role for left ventricular remodelling.
Effect of ramipril and furosemide treatment on interstitial remodeling in post-infarction heart failure rat hearts.
EMMPRIN mediates beta-adrenergic receptor-stimulated matrix metalloproteinase activity in cardiac myocytes.
Enhanced matrix metalloproteinase activity in skeletal muscles of rats with congestive heart failure.
Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat.
Heart failure alters matrix metalloproteinase gene expression and activity in rat skeletal muscle.
Icariin attenuates cardiac remodelling through down-regulating myocardial apoptosis and matrix metalloproteinase activity in rats with congestive heart failure.
Impact of metalloproteinases on left ventricular remodeling and heart failure events in patients with hypertrophic cardiomyopathy.
Inhibition of matrix metalloproteinase activity by ACE inhibitors prevents left ventricular remodeling in a rat model of heart failure.
Intracoronary Delivery of Recombinant TIMP-3 Following Myocardial Infarction: Effects on Myocardial Remodeling and Function.
Investigation of association of genetic variant rs3918242 of matrix metalloproteinase-9 with hypertension, myocardial infarction and progression of ventricular dysfunction in Irish Caucasian patients with diabetes: a report from the STOP-HF follow-up programme.
Matrix metalloproteinase activation is an early event in doxorubicin-induced cardiotoxicity.
Matrix metalloproteinase and heart failure: is it time to move from research to clinical laboratories?
Matrix metalloproteinase gene polymorphisms in heart failure: new pieces to the myocardial matrix puzzle.
Matrix metalloproteinase in left ventricular remodeling and heart failure.
Matrix metalloproteinase inhibition and the prevention of heart failure.
Matrix metalloproteinase inhibition attenuates atrial remodeling and vulnerability to atrial fibrillation in a canine model of heart failure.
Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure.
Matrix metalloproteinase inhibition during the development of congestive heart failure : effects on left ventricular dimensions and function.
Matrix metalloproteinase therapy in heart failure.
Mitochondrial MMP activation, dysfunction and arrhythmogenesis in hyperhomocysteinemia.
MMP inhibition as a potential therapeutic strategy for CHF.
MMP/TIMP expression in spontaneously hypertensive heart failure rats: the effect of ACE- and MMP-inhibition.
Myocardial matrix metalloproteinase activity and abundance with congestive heart failure.
Myocardial matrix metalloproteinase-3 and matrix metalloproteinase inhibitor-1 expression in congestive heart failure.
Oxidative remodeling in pressure overload induced chronic heart failure.
Pathways of matrix metalloproteinase induction in heart failure: bioactive molecules and transcriptional regulation.
Perspectives on the value of biomarkers in acute cardiac care and implications for strategic management.
Plasma matrix metalloproteinase and inhibitor profiles in patients with heart failure.
Plasma MMP-9 and MMP-2 following acute myocardial infarction in man: correlation with echocardiographic and neurohumoral parameters of left ventricular dysfunction.
Pravastatin increases survival and suppresses an increase in myocardial matrix metalloproteinase activity in a rat model of heart failure.
Prevention of incipient diabetic cardiomyopathy by high-dose thiamine.
Prognostic impact of matrix metalloproteinase gene polymorphisms in patients with heart failure according to the aetiology of left ventricular systolic dysfunction.
Putative targeting of matrix metalloproteinase-8 in atherosclerosis.
Role of matrix metalloproteinase-9 in endothelial apoptosis in chronic heart failure in mice.
Selective matrix metalloproteinase inhibition attenuates progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure.
Selective matrix metalloproteinase inhibition with developing heart failure: effects on left ventricular function and structure.
Serum markers of collagen turnover predict future shocks in implantable cardioverter-defibrillator recipients with dilated cardiomyopathy on optimal treatment.
Signaling pathways that influence extracellular remodeling.
The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome.
Time-dependent changes in matrix metalloproteinase activity and expression during the progression of congestive heart failure: relation to ventricular and myocyte function.
Translational Sciences in Cardiac Failure Secondary to Arteriovenous Fistula in Hemodialysis Patients.
Two MMP-2 promoter polymorphisms (-790T/G and -735C/T) in chronic heart failure.
[Expression and significance of matrix metalloproteinase-1,9, tissue inhibitor of metalloproteinase-4 and extracellular matrix metalloproteinase inducer in the myocardium of congestive heart failure in patients with rheumatic heart diseases.]
[Matrix metalloproteinases and their inhibitors in lung cancer with malignant pleural effusion]
[Microbiocenosis and activity of the inflammatory process in the colon of the patients with chronic cardiac failure].
[The activity of components of system of matrix metalloproteinase and tissue inhibitors of metalloproteinase on different stages of chronic cardiac failure].
Heart Failure, Systolic
Circulating matrix metalloproteinase-3 and metalloproteinase-9 and tissue Doppler measures of diastolic dysfunction to risk stratify patients with systolic heart failure.
Heart Rupture
Cardiac rupture complicating myocardial infarction.
Increased pericardial fluid level of matrix metalloproteinase-9 activity in patients with acute myocardial infarction: possible role in the development of cardiac rupture.
Temporal changes in matrix metalloproteinase expression and inflammatory response associated with cardiac rupture after myocardial infarction in mice.
Heart Septal Defects, Ventricular
Circulating matrix metalloproteinase levels after ventricular septal defect repair in infants.
Heart Valve Diseases
[Role of anti-angiogenic factor chondromodulin-I for maintaining cardiac valvular function]
HELLP Syndrome
Proteases and their inhibitors are indicative in gestational disease.
Hemangioma
Inhibition of angiogenesis and murine hemangioma growth by batimastat, a synthetic inhibitor of matrix metalloproteinases.
Hemangioma, Cavernous, Central Nervous System
Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1.
Hemangiosarcoma
Activation of matrix metalloproteinase (MMP)-2 by membrane type 1-MMP and abnormal immunolocalization of the basement membrane components laminin and type IV collagen in canine spontaneous hemangiosarcomas.
Hematologic Neoplasms
Matrix metalloproteinase and its drug targets therapy in solid and hematological malignancies: An overview.
Hematoma, Subdural, Chronic
[Role of matrix metalloproteinase in transformation of subdural effusion into chronic subdural hematoma]
Hemorrhagic Stroke
Donor spontaneous intracerebral hemorrhage is associated with systemic activation of matrix metalloproteinase-2 and matrix metalloproteinase-9 and subsequent development of coronary vasculopathy in the heart transplant recipient.
Hepatic Veno-Occlusive Disease
Chymase Inhibition Attenuates Monocrotaline-Induced Sinusoidal Obstruction Syndrome in Hamsters.
Sinusoidal obstruction syndrome (veno-occlusive disease) in the rat is prevented by matrix metalloproteinase inhibition.
Hepatitis
Development and Validation of a Small Single-domain Antibody That Effectively Inhibits Matrix Metalloproteinase 8.
Disparate roles for TNF-alpha and Fas ligand in concanavalin A-induced hepatitis.
Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy.
Involvement of 26-kDa cell-associated TNF-alpha in experimental hepatitis and exacerbation of liver injury with a matrix metalloproteinase inhibitor.
Matrix metalloproteinase expression correlates with virulence following neurotropic mouse hepatitis virus infection.
Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis.
Theoretical basis of a beneficial role for vitamin D in viral hepatitis.
Hepatitis B
Correlation between plasma levels of matrix metalloproteinase (MMP)-9 /MMP-2 ratio and alpha-fetoproteins in chronic hepatitis carrying hepatitis B virus.
[Application value of urinary IGFBP7 and TIMP-2 in acute kidney injury with decompensated hepatitis B virus-related liver cirrhosis].
Hepatitis B, Chronic
Evaluation of serum matrix metalloproteinase (MMP)-9 to MMP-2 ratio as a biomarker in hepatocellular carcinoma.
Hepatitis C
Association between matrix metalloproteinase (MMP)-2, MMP-9 and total antioxidant status of patients with asymptomatic hepatitis C virus infection.
Hepatitis C virus core protein promotes the migration and invasion of hepatocyte via activating transcription of extracellular matrix metalloproteinase inducer.
Matrix metalloproteinase (MMP)-2, MMP-7, and tissue inhibitor of metalloproteinase-1 are closely related to the fibroproliferative process in the liver during chronic hepatitis C.
Hepatitis C, Chronic
Diagnostic value of serum markers of connective tissue turnover for predicting histological staging and grading in patients with chronic hepatitis C.
Matrix metalloproteinase (MMP)-2, MMP-7, and tissue inhibitor of metalloproteinase-1 are closely related to the fibroproliferative process in the liver during chronic hepatitis C.
Plasma Levels of Matrix Metalloproteinase (MMP)-2, MMP-9 and Tumor Necrosis Factor-? in Chronic Hepatitis C Virus Patients.
Hepatitis, Chronic
Correlation between plasma levels of matrix metalloproteinase (MMP)-9 /MMP-2 ratio and alpha-fetoproteins in chronic hepatitis carrying hepatitis B virus.
Matrix metalloproteinase (MMP)-2, MMP-7, and tissue inhibitor of metalloproteinase-1 are closely related to the fibroproliferative process in the liver during chronic hepatitis C.
Hermanski-Pudlak Syndrome
Matrix metalloproteinase activity in the lung is increased in Hermansky-Pudlak syndrome.
Hernias, Diaphragmatic, Congenital
Elastase and matrix metalloproteinase activities are associated with pulmonary vascular disease in the nitrofen rat model of congenital diaphragmatic hernia.
Matrix metalloproteinases-2 and -9 and their endogenous tissue inhibitors in tissue remodeling after sealing of the fetal membranes in a sheep model of fetoscopic surgery.
Herpes Zoster
Altered expression of tight junction proteins and matrix metalloproteinases in thiamine-deficient mouse brain.
Caspase-1 Inhibitor Prevents Neurogenic Pulmonary Edema After Subarachnoid Hemorrhage in Mice.
Deficiency of tenascin-C and attenuation of blood-brain barrier disruption following experimental subarachnoid hemorrhage in mice.
The Traditional Chinese Medicine Compound, GRS, Alleviates Blood-Brain Barrier Dysfunction.
Hidradenitis Suppurativa
Adalimumab Induces a Wound Healing Profile in Patients with Hidradenitis Suppurativa by Regulating Macrophage Differentiation and Matrix Metalloproteinase Expression.
Hip Dislocation
Direct and indirect markers of cartilage metabolism in synovial fluid obtained from dogs with hip dysplasia and correlation with clinical and radiographic variables.
HIV Infections
Matrix metalloproteinase dysregulation in HIV infection: implications for therapeutic strategies.
Matrix metalloproteinase levels in early HIV infection and relation to in vivo brain status.
Hydrocephalus
Matrix metalloproteinases in infants with posthemorrhagic hydrocephalus.
Hydronephrosis
TIMP-1 gene expression and PAI-1 antigen after unilateral ureteral obstruction in the adult male rat.
Hyperalgesia
Absence of mechanical allodynia and Abeta-fiber sprouting after sciatic nerve injury in mice lacking membrane-type 5 matrix metalloproteinase.
Matrix Metalloproteinase Inhibitor COL-3 Prevents the Development of Paclitaxel-Induced Hyperalgesia in Mice.
Monoclonal Antibody Targeting the Matrix Metalloproteinase 9 Prevents and Reverses Paclitaxel-Induced Peripheral Neuropathy in Mice.
Role of GPCR (mu-opioid)-receptor tyrosine kinase (epidermal growth factor) crosstalk in opioid-induced hyperalgesic priming (type II).
Hyperemia
Comparative effects of diet and statin on NO bioactivity and matrix metalloproteinases in hypercholesterolemic patients with coronary artery disease.
Pleiotropic effects of angiotensin II receptor blocker in hypertensive patients.
Hyperglycemia
Pre-exposure to high glucose augments lipopolysaccharide-stimulated matrix metalloproteinase-1 expression by human U937 histiocytes.
Hyperhomocysteinemia
Cardiac synchronous and dys-synchronous remodeling in diabetes mellitus.
Four Weeks of Aerobic Training Affects Cardiac Tissue Matrix Metalloproteinase, Lactate Dehydrogenase and Malate Dehydrogenase Enzymes Activities, and Hepatorenal Biomarkers in Experimental Hyperhomocysteinemia in Rats.
Homocysteine elicits an M1 phenotype in murine macrophages through an EMMPRIN-mediated pathway.
Mitochondrial matrix metalloproteinase activation decreases myocyte contractility in hyperhomocysteinemia.
Peroxisome proliferator ameliorates endothelial dysfunction in a murine model of hyperhomocysteinemia.
[Lower extremity varicose veins in childhood and at a young age: Mechanism of development and specific features].
Hyperlipidemias
Comparative effects of statin and fibrate on nitric oxide bioactivity and matrix metalloproteinase in hyperlipidemia.
Hypersensitivity
What makes a chemical a respiratory sensitizer?
Hypertension
"Pulse" treatment with high-dose angiotensin blocker reverses renal arteriolar hypertrophy and regresses hypertension.
?1-Adrenergic blockers exert antioxidant effects, reduce matrix metalloproteinase activity, and improve renovascular hypertension-induced cardiac hypertrophy.
Alterations in vascular matrix metalloproteinase due to ageing and chronic hypertension: effects of endothelin receptor blockade.
Antioxidant effect of doxycycline decreases MMP activity and blood pressure in SHR.
Atorvastatin and sildenafil decrease vascular TGF-? levels and MMP-2 activity and ameliorate arterial remodeling in a model of renovascular hypertension.
Cerebral microhemorrhages: mechanisms, consequences and prevention.
Consistent Alterations of Circulating Matrix Metalloproteinases Levels in Untreated Hypertensives and in Spontaneously Hypertensive Rats: A Relevant Pharmacological Target.
Dermal pathology, cellular biology, and inflammation in chronic venous disease.
Doxycycline ameliorates 2K-1C hypertension-induced vascular dysfunction in rats by attenuating oxidative stress and improving nitric oxide bioavailability.
Effects of androgen on vascular and inflammatory biomarkers in a female hypertensive population.
Effects of early and late chronic pressure overload on extracellular matrix remodeling.
Extracellular matrix remodeling in the vascular wall.
Family history of hypertension, anthropometric parameters and markers of early atherosclerosis in young healthy individuals.
Genetic variants of the matrix metalloproteinase family genes and risk for hypertension: a case-control study among northeastern Han Chinese.
Imbalance between matrix metalloproteinases and tissue inhibitor of metalloproteinases in hypertensive vascular remodeling.
Increased vascular and uteroplacental matrix metalloproteinase-1 and -7 levels and collagen type I deposition in hypertension in pregnancy: role of TNF-?.
Inflammation in chronic venous ulcers.
Inhibition of matrix metalloproteinase and hypertension.
Leukocyte matrix metalloproteinase and tissue inhibitor gene expression patterns in children with primary hypertension.
Longitudinal strain and torsion assessed by two-dimensional speckle tracking correlate with the serum level of tissue inhibitor of matrix metalloproteinase-1, a marker of myocardial fibrosis, in patients with hypertension.
Matrix metalloproteinase (MMP)-2 activation by oxidative stress decreases aortic calponin-1 levels during hypertrophic remodeling in early hypertension.
Matrix metalloproteinase (MMP)-2 decreases calponin-1 levels and contributes to arterial remodeling in early hypertension.
Matrix metalloproteinase -2, -9 and arterial stiffness in children and adolescents: The role of chronic kidney disease, diabetes, and hypertension.
Matrix metalloproteinase inhibition improves cardiac dysfunction and remodeling in 2-kidney, 1-clip hypertension.
Matrix Metalloproteinase Inhibition Mitigates Renovascular Remodeling in Salt-Sensitive Hypertension.
Matrix metalloproteinase-2, -9, and tissue inhibitor of metalloproteinase-1 in patients with hypertension.
Matrix Metalloproteinases and Arterial Hypertension: Role of Oxidative Stress and Nitric Oxide in Vascular Functional and Structural Alterations.
Matrix metalloproteinases: discrete elevations in essential hypertension and hypertensive end-stage renal disease.
Nitrite treatment downregulates vascular MMP-2 activity and inhibits vascular remodeling in hypertension independently of its antihypertensive effects.
Plasma matrix metalloproteinase (MMP)-9 levels are reduced following low-calorie cranberry juice supplementation in men.
Prediction of the early response to spironolactone in resistant hypertension by the combination of matrix metalloproteinase-9 activity and arterial stiffness parameters.
Pyrrolidine dithiocarbamate downregulates vascular matrix metalloproteinases and ameliorates vascular dysfunction and remodeling in renovascular hypertension.
Quercetin decreases the activity of matrix metalloproteinase-2 and ameliorates vascular remodeling in renovascular hypertension.
Serum cardiovascular risk biomarkers in pre-pubertal obese children.
The effect of Ca2+ channel antagonists on plasma concentrations of matrix metalloproteinase-2 and -9 in essential hypertension.
Venous ulcer: what is new?
Verapamil decreases calpain-1 and matrix metalloproteinase-2 activities and improves hypertension-induced hypertrophic cardiac remodeling in rats.
[Metalloproteinase activity of the blood in patients with arterial hypertension with paroxysmal form of atrial fibrillation.]
Hypertension, Portal
The flavonoid monoHER prevents monocrotaline-induced hepatic sinusoidal injury in rats.
Hypertension, Pregnancy-Induced
Association between matrix metalloproteinase (MMP)-2 polymorphisms and MMP-2 levels in hypertensive disorders of pregnancy.
Comparative assessment of matrix metalloproteinase (MMP)-2 and MMP-9, and their inhibitors, tissue inhibitors of metalloproteinase (TIMP)-1 and TIMP-2 in preeclampsia and gestational hypertension.
Matrix metalloproteinase (MMP)-9 genotypes and haplotypes in preeclampsia and gestational hypertension.
Hypertension, Pulmonary
Changes of pulmonary pathology and gene expressions after simvastatin treatment in the monocrotaline-induced pulmonary hypertension rat model.
L-arginine attenuates acute pulmonary embolism-induced increases in lung matrix metalloproteinase-2 and matrix metalloproteinase-9.
The role of matrix metalloproteinase in the intimal sarcoma-like cells derived from endarterectomized tissues from a chronic thromboembolic pulmonary hypertension patient.
Valsartan attenuates pulmonary hypertension via suppression of mitogen activated protein kinase signaling and matrix metalloproteinase expression in rodents.
Hypertriglyceridemia
Reduction in Secretion of Very Low Density Lipoprotein-Triacylglycerol by a Matrix Metalloproteinase Inhibitor in a Rat Model of Diet-Induced Hypertriglyceridemia.
Hypertrophy, Left Ventricular
Long-term administration of nifedipine attenuates cardiac remodeling and diastolic heart failure in hypertensive rats.
Reversal of endocardial endothelial dysfunction by folic acid in homocysteinemic hypertensive rats.
Hypoalbuminemia
Effects of Albumin Infusion on Serum Levels of Albumin, Proinflammatory Cytokines (TNF-?, IL-1, and IL-6), CRP, and MMP-8; Tissue Expression of EGRF, ERK1, ERK2, TGF-?, Collagen, and MMP-8; and Wound Healing in Sprague Dawley Rats.
Hyponatremia
Time-dependent changes in proinflammatory and neurotrophic responses of microglia and astrocytes in a rat model of osmotic demyelination syndrome.
Hypopharyngeal Neoplasms
Expression of invasion markers CD44v6/v3, NM23 and MMP2 in laryngeal and hypopharyngeal carcinoma.
Idiopathic Interstitial Pneumonias
Characteristic elevation of matrix metalloproteinase activity in idiopathic interstitial pneumonias.
Idiopathic Pulmonary Fibrosis
An alternative therapy for idiopathic pulmonary fibrosis by doxycycline through matrix metalloproteinase inhibition.
Differential Responses to Targeting Matrix Metalloproteinase 9 in Idiopathic Pulmonary Fibrosis.
Elevated matrilysin levels in bronchoalveolar lavage fluid do not distinguish idiopathic pulmonary fibrosis from other interstitial lung diseases.
Is metalloproteinase-7 specific for idiopathic pulmonary fibrosis?
Matrix metalloproteinase-9 in lung remodeling.
Matrix metalloproteinase: An upcoming therapeutic approach for idiopathic pulmonary fibrosis.
Matrix metalloproteinases and tissue inhibitor of metalloproteinase-1 in sarcoidosis and IPF.
MMP expression and abnormal lung permeability are important determinants of outcome in IPF.
Mononuclear phagocytes and airway epithelial cells: novel sources of matrix metalloproteinase-8 (MMP-8) in patients with idiopathic pulmonary fibrosis.
Profibrotic Activities for Matrix Metalloproteinase-8 during Bleomycin-Mediated Lung Injury.
Serum biomarkers reflecting specific tumor tissue remodeling processes are valuable diagnostic tools for lung cancer.
Infarction, Middle Cerebral Artery
Analysis of regulatory effect of miR-149-5p on Sphingosine-1-phosphate receptor 2 of pericytes and its neuroprotective molecular mechanism after acute cerebral ischemia reperfusion in rats.
Crotalus atrox disintegrin reduces hemorrhagic transformation by attenuating matrix metalloproteinase-9 activity after middle cerebral artery occlusion in hyperglycemic male rats.
Inhibition of matrix metalloproteinase-9 activity by trandolapril after middle cerebral artery occlusion in rats.
Matrix metalloproteinase (MMP) induction and inhibition at different doses of recombinant tissue plasminogen activator following experimental stroke.
Infections
A matrix metalloproteinase inhibitor promotes granuloma formation during the early phase of Mycobacterium tuberculosis pulmonary infection.
A rapid matrix metalloproteinase-8 bedside test for the detection of intraamniotic inflammation in women with preterm premature rupture of membranes.
A rapid MMP-8 bedside test for the detection of intra-amniotic inflammation identifies patients at risk for imminent preterm delivery.
Ablation of matrix metalloproteinase-9 increases severity of viral myocarditis in mice.
Activation of AMPK in human fetal membranes alleviates infection-induced expression of pro-inflammatory and pro-labour mediators.
Activation of neutrophil collagenase in periodontitis.
Adjunct antibody administration with standard treatment reduces relapse rates in a murine tuberculosis model of necrotic granulomas.
Amniotic fluid matrix metalloproteinase-8 in preterm labor with intact membranes.
Amniotic fluid matrix metalloproteinase-8 indicates intra-amniotic infection.
Antibiotic administration can eradicate intra-amniotic infection or intra-amniotic inflammation in a subset of patients with preterm labor and intact membranes.
ATF3 is a negative regulator of inflammation in human fetal membranes.
Basement membrane protein and matrix metalloproteinase deregulation in engineered human oral mucosa following infection with Candida albicans.
Batimastat reduces Mycobacterium tuberculosis-induced apoptosis in macrophages.
beta-Catenin/Wnt signaling regulates expression of the membrane type 3 matrix metalloproteinase in gastric cancer.
Bi-layered nanocomposite bandages for controlling microbial infections and overproduction of matrix metalloproteinase activity.
Bovine herpesvirus-5 infection in a rabbit experimental model: Immunohistochemical study of the cellular response in the CNS.
Chlamydia trachomatis enhances the expression of matrix metalloproteinases in an in vitro model of the human fallopian tube infection.
Clinical chorioamnionitis at term VIII: a rapid MMP-8 test for the identification of intra-amniotic inflammation.
Clinical Chorioamnionitis at Term: New Insights into the Etiology, Microbiology, and the Fetal, Maternal and Amniotic Cavity Inflammatory Responses.
Comparison of amniotic fluid matrix metalloproteinase-8 and cathelicidin in the diagnosis of intra-amniotic infection.
Comparison of rapid MMP-8 and interleukin-6 point-of-care tests to identify intra-amniotic inflammation/infection and impending preterm delivery in patients with preterm labor and intact membranes().
Coxsackievirus A2 Leads to Heart Injury in a Neonatal Mouse Model.
Cryptococcus neoformans pulmonary granuloma formation is associated with matrix metalloproteinase-2 expression.
Dexamethasone prevents alteration of tight junction-associated proteins and barrier function in porcine choroid plexus epithelial cells after infection with Streptococcus suis in vitro.
Differential regulation of MMP-1/9 and TIMP-1 secretion in human monocytic cells in response to Mycobacterium tuberculosis.
Downregulation of miR?29b?3p promotes ??tubulin deacetylation by targeting the interaction of matrix metalloproteinase?9 with integrin ?1 in nasal polyps.
Dual protective mechanisms of matrix metalloproteinases 2 and 9 in immune defense against Streptococcus pneumoniae.
Effect of a matrix metalloproteinase inhibitor on host resistance against Listeria monocytogenes infection.
Effect of E. faecalis on the release of serine proteases elastase and cathepsin G, and collagenase-2 (MMP-8) by human polymorphonuclear leukocytes (PMNs).
Effect of respiratory syncytial virus on the activity of matrix metalloproteinase in mice.
Effects of the knockdown of hypoxia inducible factor-1? expression by adenovirus-mediated shRNA on angiogenesis and tumor growth in hepatocellular carcinoma cell lines.
Enhanced systemic matrix metalloproteinase response in Helicobacter pylori gastritis.
Evaluation of the Biological Effects of Lyophilized Hydrophilic Extract of Rhus coriaria on Myeloperoxidase (MPO) Activity, Wound Healing, and Microbial Infections of Skin Wound Tissues.
Evidence that antibiotic administration is effective in the treatment of a subset of patients with intra-amniotic infection/inflammation presenting with cervical insufficiency.
Expression of Interleukin-1? and Matrix Metalloproteinase-8 in Cytolytic and Noncytolytic Enterococcus faecalis-induced Persistent Apical Periodontitis: A Comparative Study in the Rat.
Extracellular matrix metalloproteinase inducer enhances host resistance against pseudomonas aeruginosa infection through MAPK signaling pathway.
Genetic variants in matrix metalloproteinase genes are associated with development of gastric ulcer in H. Pylori infection.
Global cytokine/chemokine profile identifies potential progression prediction indicators in hand-foot-and-mouth disease patients with Enterovirus A71 infections.
GM-CSF- and TNF-{alpha}-mediated matrix metalloproteinase production by human osteoblasts and monocytes upon infection with Brucella abortus.
Helicobacter pylori potentiates epithelial:mesenchymal transition in gastric cancer: links to soluble HB-EGF, gastrin and matrix metalloproteinase-7.
High fat diet modulates inflammatory parameters in the heart and liver during acute Trypanosoma cruzi infection.
Host gene-encoded severe lung TB: from genes to the potential pathways.
Host single nucleotide polymorphisms of MMP-9 -1562/TIMP-1 372 have gender differences in the risk of gastric intestinal metaplasia after Helicobacter pylori infection.
Human Cytomegalovirus Encoded miR-US25-1-5p Attenuates CD147/EMMPRIN-Mediated Early Antiviral Response.
Human cytomegalovirus-induced inhibition of cytotrophoblast invasion in a first trimester extravillous cytotrophoblast cell line.
Human neutrophil collagenase (matrix metalloproteinase 8) in parturition, premature rupture of the membranes, and intrauterine infection.
Human parasitic meningitis caused by Angiostrongylus cantonensis infection in Taiwan.
Human polynucleotide phosphorylase (hPNPaseold-35): a potential link between aging and inflammation.
Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection.
Immunomodulation by interleukin-4 suppresses matrix metalloproteinases and improves cardiac function in murine myocarditis.
Increased activities of cardiac matrix metalloproteinases matrix metalloproteinase (MMP)-2 and MMP-9 are associated with mortality during the acute phase of experimental Trypanosoma cruzi infection.
Induction of matrix metalloproteinase-2 and -9 via Erk1/2-NF-?B pathway in human astroglia infected with Toxoplasma gondii.
Influence of vaginal bacteria and D- and L-lactic acid isomers on vaginal extracellular matrix metalloproteinase inducer: implications for protection against upper genital tract infections.
Interleukin 1beta induces gastric epithelial cell matrix metalloproteinase secretion and activation during Helicobacter pylori infection.
KSHV activation of VEGF secretion and invasion for endothelial cells is mediated through viral upregulation of emmprin-induced signal transduction.
Lung transplant metalloproteinase levels are elevated prior to bronchiolitis obliterans syndrome.
Mast cell proteases as protective and inflammatory mediators.
Matrix metalloproteinase (MMP)-2 and MMP-9 as inflammation markers of Trichinella spiralis and Trichinella pseudospiralis infections in mice.
Matrix Metalloproteinase Activity in Infections by an Encephalitic Virus, Mouse Adenovirus Type 1.
Matrix metalloproteinase expression correlates with virulence following neurotropic mouse hepatitis virus infection.
Matrix metalloproteinase MMP-8, TIMP-1 and MMP-8/TIMP-1 ratio in plasma in methicillin-sensitive Staphylococcus aureus bacteremia.
Matrix metalloproteinase-7 disrupts dendritic spines in hippocampal neurons through NMDA receptor activation.
Matrix metalloproteinase-9 leads to blood-brain barrier leakage in mice with eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis.
Matrix Metalloproteinase-9 Leads to Claudin-5 Degradation via the NF-?B Pathway in BALB/c Mice with Eosinophilic Meningoencephalitis Caused by Angiostrongylus cantonensis.
Matrix Metalloproteinase-9 Mediates RSV Infection in Vitro and in Vivo.
Matrix metalloproteinases contribute to brain damage in experimental pneumococcal meningitis.
Matrix metalloproteinases in the cervical mucus plug in relation to gestational age, plug compartment, and preterm labor.
Matrix Metalloproteinases Vary with Airway Microbiota Composition and Lung Function in Non-Cystic Fibrosis Bronchiectasis.
Mechanisms of matrix metalloproteinase-9 upregulation and tissue destruction in various organs in influenza A virus infection.
Methicillin-Resistant Staphylococcus Aureus infection exacerbates NSCLC cell metastasis by up-regulating TLR4/MyD88 pathway.
Microbiological and biochemical findings in relation to clinical periodontal status in active smokers, non-smokers and passive smokers.
MMP cellular responses to dengue virus infection-induced vascular leakage.
Modified Profile of Matrix Metalloproteinase 2 and 9 Production by Human Fallopian Tube Epithelial Cells After Infection In Vitro With Neisseria gonorrhoeae.
Neisseria gonorrhoeae Challenge Increases Matrix Metalloproteinase-8 Expression in Fallopian Tube Explants.
Persistent Oral Human Papillomavirus (HPV) Infection is Associated with Low Salivary Levels of Matrix Metalloproteinase 8 (MMP-8).
Pulmonary matrix metalloproteinase-9 activity in mechanically ventilated children with respiratory syncytial virus.
Quantitative proteomics identify an association between extracellular matrix degradation and immunopathology of genotype VII Newcastle disease virus in the spleen in chickens.
Real-time quantification of matrix metalloproteinase and integrin ?v?3 expression during biomaterial-associated infection in a murine model.
Regulation of matrix metalloproteinase (MMP) and tissue inhibitor of matrix metalloproteinase (TIMP) genes during JHMV infection of the central nervous system.
Rhinovirus-induces progression of lung disease in a mouse model of COPD via IL-33/ST2 signaling axis.
Sendai virus infection up-regulates trypsin I and matrix metalloproteinase-9, triggering viral multiplication and matrix degradation in rat lungs and lung L2 cells.
Streptococcus pyogenes degrades extracellular matrix in chondrocytes via MMP-13.
T cell production of matrix metalloproteases and inhibition of parasite clearance by TIMP-1 during chronic Toxoplasma infection in the brain.
T-cell production of matrix metalloproteinases and inhibition of parasite clearance by TIMP-1 during chronic Toxoplasma infection in the brain.
Targeting extracellular cyclophilins ameliorates disease progression in experimental biliary atresia.
The antidepressant fluoxetine protects the hippocampus from brain damage in experimental pneumococcal meningitis.
The frequency and clinical significance of intra-uterine infection and inflammation in patients with placenta previa and preterm labor and intact membranes.
The intensity of the fetal inflammatory response in intraamniotic inflammation with and without microbial invasion of the amniotic cavity.
The matrix metalloproteinase gene GmMMP2 is activated in response to pathogenic infections in soybean.
The Relationship Between Matrix Metalloproteinase-8 in After Birth Oral Fluid and Acute Histologic Chorioamnionitis in Preterm Delivery.
The role of HIV-1 activated leukocyte adhesion mechanisms and matrix metalloproteinase secretion in AIDS pathogenesis (Review).
The role of matrix metalloproteinase-7 in redefining the gastric microenvironment in response to Helicobacter pylori.
The Role of Matrix Metalloproteinases in Development, Repair, and Destruction of the Lungs.
Time-dependent matrix metalloproteinases and tissue inhibitor of metalloproteinases expression change in fusarium solani keratitis.
Truncated active matrix metalloproteinase-8 gene expression in HepG2 cells is active against native type I collagen.
Upregulation of extracellular matrix metalloproteinase inducer (EMMPRIN) and gelatinases in human atherosclerosis infected with Chlamydia pneumoniae: the potential role of Chlamydia pneumoniae infection in the progression of atherosclerosis.
Urinary NGAL Measured after the First Year Post Kidney Transplantation Predicts Changes in Glomerular Filtration over One-Year Follow-Up.
Use of MMP-8 and MMP-9 to assess disease severity in children with viral lower respiratory tract infections.
Value of amniotic fluid neutrophil collagenase concentrations in preterm premature rupture of membranes.
[The immunopathology mechanisms of matrix metalloproteinases in brain infection induced by parasites].
Infertility, Male
Overexpression of the matrix metalloproteinase matrilysin results in premature mammary gland differentiation and male infertility.
Inflammatory Bowel Diseases
Focus issue: understanding mechanisms of inflammation.
Gelatinase A (MMP-2), collagenase-2 (MMP-8), and laminin-5 gamma2-chain expression in murine inflammatory bowel disease (ulcerative colitis).
In vitro evaluation of compression-coated glycyl-l-histidyl-l-lysine-Cu(II) (GHK-Cu(2+))-loaded microparticles for colonic drug delivery.
Increased expression of Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) and MMP10, MMP23 in inflammatory bowel disease: cross-sectional study.
Matrix metalloproteinase levels are elevated in inflammatory bowel disease.
Matrix metalloproteinase-9 regulates MUC-2 expression through its effect on goblet cell differentiation.
Role of matrix metalloproteinase, tissue inhibitor of metalloproteinase and tumor necrosis factor-alpha single nucleotide gene polymorphisms in inflammatory bowel disease.
Influenza in Birds
Targeted retroviral vectors displaying a cleavage site-engineered hemagglutinin (HA) through HA-protease interactions.
Influenza, Human
Mechanisms of matrix metalloproteinase-9 upregulation and tissue destruction in various organs in influenza A virus infection.
Targeting the Host Response: Can We Manipulate Extracellular Matrix Metalloproteinase Activity to Improve Influenza Virus Infection Outcomes?
Insulin Resistance
Association of MMP-8 with obesity, smoking and insulin resistance.
Cellular fibronectin response to supervised moderate aerobic training in patients with type 2 diabetes.
Countermeasures for pasture-associated laminitis in ponies and horses.
Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women.
Pioglitazone improves left ventricular diastolic function in patients with essential hypertension.
Proof of Concept: Matrix metalloproteinase inhibitor decreases inflammation and improves muscle insulin sensitivity in people with type 2 diabetes.
interstitial collagenase deficiency
MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing.
Intervertebral Disc Degeneration
ISSLS prize in basic science 2021: a novel inducible system to regulate transgene expression of TIMP1.
Matrix metalloproteinase (MMP)-3 gene up-regulation in a rat tail compression loading-induced disc degeneration model.
[Effect of electroacupuncture intervention on expression of extracellular matrix collagen and metabolic enzymes].
[Effects of electroacupuncture at Jiaji (EX-B 2) on extracellular matrix MMP-1, MMP-3 and TIMP-1 levels in the degenerated cervical intervertebral disc in rats]
[Study on yiqi huayu bushen recipe and its disassembled recipes in regulating mRNA expression of collagens and metabolic enzymes in extracellular matrix of cervical disc]
Intervertebral Disc Displacement
Analysis of cartilage oligomeric matrix protein and matrix metalloproteinase-9 in cerebrospinal fluid of miniature dachshund with intervertebral disc herniation.
Correlation of matrix metalloproteinases-1 and -3 with patient age and grade of lumbar disc herniation.
Effects of MMP-1 and MMP-3 gene polymorphisms on gene expression and protein level in lumbar disc herniation.
Matrix metalloprotease-9 activity in the cerebrospinal fluid and spinal injury severity in dogs with intervertebral disc herniation.
Matrix metalloproteinase expression levels suggest distinct enzyme roles during lumbar disc herniation and degeneration.
Matrix metalloproteinases and aggrecanase: their role in disorders of the human intervertebral disc.
The involvement of matrix metalloproteinases and inflammation in lumbar disc herniation.
Up-regulated expression of matrilysin and neutrophil collagenase in human herniated discs.
Intracranial Aneurysm
A failure of matrix metalloproteinase inhibition in the prevention of rat intracranial aneurysm formation.
Association of functional MMP-2 gene variant with intracranial aneurysms: case-control genetic association study and meta-analysis.
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Intracranial Hemorrhages
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Reperfusion and Neurovascular Dysfunction in Stroke: from Basic Mechanisms to Potential Strategies for Neuroprotection.
Ischemic Stroke
Association between Inflammatory Biomarkers and Progression of Intracranial Large Artery Stenosis after Ischemic Stroke.
Association Between Matrix Metalloproteinase Family Gene Polymorphisms and Ischemic Stroke: a Meta-analysis.
Association between matrix metalloproteinase family gene polymorphisms and risk of ischemic stroke: A systematic review and meta-analysis of 29 studies.
Association between matrix metalloproteinase gene polymorphisms and development of ischemic stroke.
Association between the Matrix Metalloproteinase-9 rs3918242 Polymorphism and Ischemic Stroke Susceptibility: A Meta-Analysis.
Bone marrow-derived cells are the major source of MMP-9 contributing to blood-brain barrier dysfunction and infarct formation after ischemic stroke in mice.
Causal associations of serum matrix metalloproteinase-8 level with ischaemic stroke and ischaemic stroke subtypes: a Mendelian randomization study.
Causal Effect of MMP-1 (Matrix Metalloproteinase-1), MMP-8, and MMP-12 Levels on Ischemic Stroke: A Mendelian Randomization Study.
Combined Effects of MMP-7, MMP-8 and MMP-26 on the Risk of Ischemic Stroke.
Increased intranuclear matrix metalloproteinase activity in neurons interferes with oxidative DNA repair in focal cerebral ischemia.
Intraplaque MMP-8 levels are increased in asymptomatic patients with carotid plaque progression on ultrasound.
Meta-analysis of matrix metalloproteinase (MMP)-9 C1562T polymorphism and susceptibility to ischemic stroke in the Chinese population.
Recombinant tissue plasminogen activator induces blood-brain barrier breakdown by a matrix metalloproteinase-9-independent pathway after transient focal cerebral ischemia in mouse.
Role of matrix metalloproteinase activity in the neurovascular protective effects of Angiotensin antagonism.
Serum matrix metalloproteinase-8, tissue inhibitor of metalloproteinase and myeloperoxidase in ischemic stroke.
The Role of High Mobility Group Box 1 in Ischemic Stroke.
The Role of Matrix Metalloproteinase Polymorphisms in Ischemic Stroke.
The significance of matrix metalloproteinase (MMP)-2 and MMP-9 in the ischemic stroke.
Joint Diseases
Al-Aqeel Sewairi syndrome, a new autosomal recessive disorder with multicentric osteolysis, nodulosis and arthropathy. The first genetic defect of matrix metalloproteinase 2 gene.
Assessment of the effects of age and joint disease on hydroxyproline and glycosaminoglycan concentrations in synovial fluid from the metacarpophalangeal joint of horses.
Biological strategies for osteoarthritis: from early diagnosis to treatment.
cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis.
Characterization of Normal Murine Carpal Bone Development Prompts Re-Evaluation of Pathologic Osteolysis as the Cause of Human Carpal-Tarsal Osteolysis Disorders.
Effects of the antirheumatic remedy hox alpha--a new stinging nettle leaf extract--on matrix metalloproteinases in human chondrocytes in vitro.
Gelatinase activity in synovial fluid and synovium obtained from healthy and osteoarthritic joints of dogs.
Matrix metalloproteinase, vitamin A and methylprednisolone effects on experimentally induced amyloid arthropathy.
MiRNA-140 is a negative feedback regulator of MMP-13 in IL-1?-stimulated human articular chondrocyte C28/I2 cells.
Protein kinase C isoforms zeta and iota mediate collagenase expression and cartilage destruction via STAT3- and ERK-dependent c-fos induction.
Reduction of interleukin-1? induced matrix metalloproteinase-3 release by extracts of six plants: inhibitory screening of 35 traditional medicinal plants.
Synovial fluid gelatinase concentrations and matrix metalloproteinase and cytokine expression in naturally occurring joint disease in horses.
The role of IL-17-secreting mast cells in inflammatory joint disease.
[The matrix metalloproteinase gene family: structure, function, expression, and role in destructive joint disease]
Keloid
Correlation between Serum 25-Hydroxyvitamin D Levels with Keloid Severity.
Effects of hepatocyte growth factor on collagen synthesis and matrix metalloproteinase production in keloids.
Promoted activation of matrix metalloproteinase (MMP)-2 in keloid fibroblasts and increased expression of MMP-2 in collagen bundle regions: implications for mechanisms of keloid progression.
Relaxin-expressing adenovirus decreases collagen synthesis and up-regulates matrix metalloproteinase expression in keloid fibroblasts: in vitro experiments.
Suppressed TGF-beta1 expression is correlated with up-regulation of matrix metalloproteinase-13 in keloid regression after flashlamp pulsed-dye laser treatment.
Tretinoin reverses upregulation of matrix metalloproteinase-13 in human keloid-derived fibroblasts.
Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis.
Keratitis
Biofilm microenvironment activated supramolecular nanoparticles for enhanced photodynamic therapy of bacterial keratitis.
Correlation between matrix metalloproteinase expression and activation of the focal adhesion kinase signaling pathway in herpes stromal keratitis.
Elevated Expression and Activation of Matrix Metalloproteinase 8 in Tear Fluid in Atopic Blepharoconjunctivitis.
Evaluation of matrix metalloproteinase concentrations in precorneal tear film from dogs with Pseudomonas aeruginosa-associated keratitis.
Expression of matrix metalloproteinases during experimental Candida albicans keratitis.
Inhibition of matrix metalloproteins 9 attenuated Candida albicans induced inflammation in mouse cornea.
Inhibition of pseudomonal ulceration in rabbit corneas by a synthetic matrix metalloproteinase inhibitor.
Matrix metalloproteinases (MMP-8, MMP-9) and the tissue inhibitors of metalloproteinases (TIMP-1, TIMP-2) in patients with fungal keratitis.
Secretory Leukoprotease Inhibitor: A Native Antimicrobial Protein in the Innate Immune Response in a Rat Model of S. aureus Keratitis.
Testican-1 Promotes Resistance against Pseudomonas aeruginosa-Induced Keratitis through Regulation of MMP-2 Expression and Activation.
[The roles of gelatinases in pathological changes of fungal keratitis in experimental rabbits]
Keratoacanthoma
Transformation-specific matrix metalloproteinases, MMP-7 and MMP-13, are present in epithelial cells of keratoacanthomas.
Keratoconus
Acute hypoxia influences collagen and matrix metalloproteinase expression by human keratoconus cells in vitro.
Collagenolytic proteinases in keratoconus.
EMMPRIN and MMP-1 in keratoconus.
Expression of degradative enzymes and protease inhibitors in corneas with keratoconus.
Induction of matrix metalloproteinase-1 by tumor necrosis factor-? is mediated by interleukin-6 in cultured fibroblasts of keratoconus.
Keratoconus: an inflammatory disorder?
Matrix metalloproteinases (MMP-8, MMP-9) and the tissue inhibitors of metalloproteinases (TIMP-1, TIMP-2) in patients with fungal keratitis.
Role of extracellular matrix remodelling gene SNPs in keratoconus.
The Enigma of Environmental Factors in Keratoconus.
Kidney Diseases
Plasma neutrophil gelatinase-associated lipocalin levels are associated with the presence and severity of coronary heart disease.
Kidney Failure, Chronic
Cubilin Single Nucleotide Polymorphism Variants are Associated with Macroangiopathy While a Matrix Metalloproteinase-9 Single Nucleotide Polymorphism Flip-Flop may Indicate Susceptibility of Diabetic Nephropathy in Type-2 Diabetic Patients.
Inflammatory response and matrix metalloproteinases in chronic kidney failure: Modulation by adropin and spexin.
Matrix Metalloproteinase (MMP)-2 Genetic Variants Modify the Circulating MMP-2 Levels in End-Stage Kidney Disease.
Kidney Neoplasms
Expression of thrombospondin-derived 4N1K peptide-containing proteins in renal cell carcinoma tissues is associated with a decrease in tumor growth and angiogenesis.
Kounis Syndrome
Extracellular matrix metalloproteinase inducer (EMMPRIN), acute myocardial infarction and the Kounis syndrome.
Laryngeal Neoplasms
Pituitary tumor-transforming 1 expression in laryngeal cancer and its association with prognosis.
Prognostic significance of the immunoexpression of matrix metalloproteinase MMP2 and its inhibitor TIMP2 in laryngeal cancer.
Serum matrix metalloproteinase 8 and tissue inhibitor of metalloproteinase 1: Potential markers for malignant transformation of recurrent respiratory papillomatosis and for prognosis of laryngeal cancer.
The matrix metalloproteinase in larynx cancer.
Leg Ulcer
Analysis of the acute and chronic wound environments: the role of proteases and their inhibitors.
Effect of collagen turnover and matrix metalloproteinase activity on healing of venous leg ulcers.
Elevated expression of extracellular matrix metalloproteinase inducer (CD147) and membrane-type matrix metalloproteinases in venous leg ulcers.
Expression of matrix metalloproteinase (MMP)-7 and MMP-13 and loss of MMP-19 and p16 are associated with malignant progression in chronic wounds.
Hydroxyurea-induced leg ulcers treated with a protease-modulating matrix.
Matrix Metalloproteinase Profiles in Chronic Venous Ulcer Wound Fluid of Inflammatory and Granulating Venous Leg Ulcers.
Matrix metalloproteinases, gelatinase and collagenase, in chronic leg ulcers.
Plasminogen activation in venous leg ulcers.
The Impact of Differential Expression of Extracellular Matrix Metalloproteinase Inducer, Matrix Metalloproteinase-2, Tissue Inhibitor of Matrix Metalloproteinase-2 and PDGF-AA on the Chronicity of Venous Leg Ulcers.
The role of matrix metalloproteinases in wound healing.
Leiomyoma
Increased expression of stromelysin 3 mRNA in leiomyomas (uterine fibroids) compared with myometrium.
MicroRNA 21a-5p overexpression impacts mediators of extracellular matrix formation in uterine leiomyoma.
Progesterone receptor modulator CDB-2914 induces extracellular matrix metalloproteinase inducer in cultured human uterine leiomyoma cells.
Selective progesterone receptor modulator asoprisnil down-regulates collagen synthesis in cultured human uterine leiomyoma cells through up-regulating extracellular matrix metalloproteinase inducer.
The function role and synergic effect of syndecan-1 for mifepristone in uterine leiomyoma.
Translational research with progesterone receptor modulator motivated by the use of levonorgestrel-releasing intrauterine system.
Lentivirus Infections
Lentivirus infection in the brain induces matrix metalloproteinase expression: role of envelope diversity.
Leprosy
High matrix metalloproteinase production correlates with immune activation and leukocyte migration in leprosy reactional lesions.
Leukemia
Assessment of Cannabinoids Agonist and Antagonist in Invasion Potential of K562 Cancer Cells
Critical role and its underlying molecular events of the plasminogen receptor, S100A10 in malignant tumor and non-tumor diseases.
Doxycycline induces apoptosis by way of caspase-3 activation with inhibition of matrix metalloproteinase in human T-lymphoblastic leukemia CCRF-CEM cells.
Expression of matrix metalloproteinase (MMP) and tissue inhibitor of MMP (TIMP) genes in blasts of infant acute lymphoblastic leukemia with organ involvement.
Expression of neutrophil collagenase (MMP-8) in Jurkat T leukemia cells and its role in invasion.
Growth of tyrosine kinase inhibitor-resistant Philadelphia-positive acute lymphoblastic leukemia: Role of bone marrow stromal cells.
High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis.
Human T cell leukemia virus type I (HTLV-I)-specific CD8+ CTL clones from patients with HTLV-I-associated neurologic disease secrete proinflammatory cytokines, chemokines, and matrix metalloproteinase.
Inhibition of matrix metalloproteinases expression in human dental pulp cells by all-trans retinoic acid.
Matrix metalloproteinase-2 and -9 secreted by leukemic cells increase the permeability of blood-brain barrier by disrupting tight junction proteins.
Orostachys japonicus inhibits the expression of MMP-2 and MMP-9 mRNA and modulates the expression of iNOS and COX-2 genes in human PMA-differentiated THP-1 cells via inhibition of NF-?B and MAPK activation.
Peroxisome proliferator activated receptor-gamma ligands induced cell growth inhibition and its influence on matrix metalloproteinase activity in human myeloid leukemia cells.
Peroxisome proliferator-activated receptor and retinoid X receptor ligands inhibit monocyte chemotactic protein-1-directed migration of monocytes.
Recombinant Multivalent EMMPRIN Extracellular Domain Induces U937 Human Leukemia Cell Apoptosis by Downregulation of Monocarboxylate Transporter 1 and Activation of Procaspase-9.
The Contribution of MMP-8 Promoter Genotypes to Childhood Leukemia.
The possible role of matrix metalloproteinase (MMP)-2 and MMP-9 in cancer, e.g. acute leukemia.
[Acetyl-11-keto-beta-boswellic acid and arsenic trioxide regulate the productions and activities of matrix metalloproteinases in human skin fibroblasts and human leukemia cell line THP-1].
Leukemia, Monocytic, Acute
Peroxisome proliferator-activated receptor and retinoid X receptor ligands inhibit monocyte chemotactic protein-1-directed migration of monocytes.
[Acetyl-11-keto-beta-boswellic acid and arsenic trioxide regulate the productions and activities of matrix metalloproteinases in human skin fibroblasts and human leukemia cell line THP-1].
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases.
Matrix metalloproteinase production by bone marrow mononuclear cells from normal individuals and patients with acute and chronic myeloid leukemia or myelodysplastic syndromes.
Leukemia, Myeloid
A new matrix metalloproteinase inhibitor SI-27 induces apoptosis in several human myeloid leukemia cell lines and enhances sensitivity to TNF alpha-induced apoptosis.
Peroxisome proliferator activated receptor-gamma ligands induced cell growth inhibition and its influence on matrix metalloproteinase activity in human myeloid leukemia cells.
Leukemia, Myeloid, Acute
Hispidulin induces mitochondrial apoptosis in acute myeloid leukemia cells by targeting extracellular matrix metalloproteinase inducer.
[Relationship between VEGF and MMP-2, MMP-9 in 82 Patients with Acute Myeloid Leukemia.]
Leukemia, Promyelocytic, Acute
Critical role and its underlying molecular events of the plasminogen receptor, S100A10 in malignant tumor and non-tumor diseases.
Leukemia, T-Cell
Human T cell leukemia virus type I (HTLV-I)-specific CD8+ CTL clones from patients with HTLV-I-associated neurologic disease secrete proinflammatory cytokines, chemokines, and matrix metalloproteinase.
Leukemia-Lymphoma, Adult T-Cell
Testican 3 expression in adult T-cell leukemia.
Leukocytosis
Factors affecting matrix metalloproteinase-8 levels in the vaginal and cervical fluids in the first and second trimester of pregnancy.
Leukoplakia
TNF-alpha drives matrix metalloproteinase-9 in squamous oral carcinogenesis.
Lichen Planus
MMPs, TIMP-2, and TGF-beta1 in the cancerization of oral lichen planus.
Lichen Planus, Oral
Matrix metalloproteinase gene expression in oral lichen planus: erosive vs. reticular forms.
MMPs, TIMP-2, and TGF-beta1 in the cancerization of oral lichen planus.
Zinc Therapy in Treatment of Symptomatic Oral Lichen Planus.
Lipedema
The MMP14-caveolin axis and its potential relevance for lipoedema.
Liver Cirrhosis
A cut above the rest? MMP-8 and liver fibrosis gene therapy.
Accelerated liver fibrosis in hepatitis B virus transgenic mice: involvement of natural killer T cells.
Activity of MMP-2, MMP-8 and MMP-9 in serum as a marker of progression of alcoholic liver disease in people from Lublin Region, eastern Poland.
Adenoviral delivery of dominant-negative transforming growth factor beta type II receptor up-regulates transcriptional repressor SKI-like oncogene, decreases matrix metalloproteinase 2 in hepatic stellate cell and prevents liver fibrosis in rats.
Adenoviral delivery of truncated MMP-8 fused with the hepatocyte growth factor mutant 1K1 ameliorates liver cirrhosis and promotes hepatocyte proliferation.
Anti-fibrotic effect of Cordyceps sinensis polysaccharide: Inhibiting HSC activation, TGF-?1/Smad signalling, MMPs and TIMPs.
Broad-spectrum matrix metalloproteinase inhibition curbs inflammation and liver injury but aggravates experimental liver fibrosis in mice.
Carvedilol attenuates carbon tetrachloride-induced liver fibrosis and hepatic sinusoidal capillarization in mice.
CD34(+) cell therapy is safe and effective in slowing the decline of hepatic reserve function in patients with decompensated liver cirrhosis.
Characterization of metalloproteinases, oxidative status and inflammation levels in the different stages of fibrosis in HCV patients.
Chymase inhibitor prevents the nonalcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet.
Enhanced liver fibrosis (ELF) test in obese children with ultrasound-proven liver steatosis.
Enhanced liver fibrosis marker as a noninvasive predictor of mortality in HIV/hepatitis C virus-coinfected women from a multicenter study of women with or at risk for HIV.
Improvement of liver fibrosis by infusion of cultured cells derived from human bone marrow.
Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: implications for reversibility of liver fibrosis.
Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/?-Catenin Reduces Liver Fibrosis in Mice.
Leptin represses matrix metalloproteinase-1 gene expression in LX2 human hepatic stellate cells.
Matrilysin (MMP-7) is a major matrix metalloproteinase upregulated in biliary atresia-associated liver fibrosis.
Matrix metalloproteinase gene delivery for liver fibrosis.
Matrix metalloproteinase-8 (MMP-8) regulates the activation of hepatic stellate cells (HSCs) through the ERK-mediated pathway.
Mesenchymal stem cell infusion therapy in carbon tetrachloride-induced liver fibrosis model affects matrix metalloproteinase expression.
Phosphodiesterase inhibition mediates matrix metalloproteinase activity and the level of collagen degradation fragments in a liver fibrosis ex vivo rat model.
Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis.
Secreted matrix metalloproteinase-14 is a predictor for antifibrotic effect of IC-2-engineered mesenchymal stem cell sheets on liver fibrosis in mice.
Significance and therapeutic potential of endothelial progenitor cell transplantation in a cirrhotic liver rat model.
Silybin-vitamin E-phospholipids complex reduces liver fibrosis in patients with chronic hepatitis C treated with pegylated interferon ? and ribavirin.
The immunoreactivity of TGF-b1 in non-alcoholic fatty liver disease.
Transcriptional regulation of alcohol induced liver fibrosis in a translational porcine hepatocellular carcinoma model.
Treatment with human metalloproteinase-8 gene delivery ameliorates experimental rat liver cirrhosis.
Truncated active human matrix metalloproteinase-8 delivered by a chimeric adenovirus-hepatitis B virus vector ameliorates rat liver cirrhosis.
[Application value of urinary IGFBP7 and TIMP-2 in acute kidney injury with decompensated hepatitis B virus-related liver cirrhosis].
[Combined effects of antisense TBRI eukaryotic expressing plasmid and antisense TIMP-1 eukaryotic expressing plasmid on rat liver fibrosis]
Liver Cirrhosis, Alcoholic
Activity of MMP-2, MMP-8 and MMP-9 in serum as a marker of progression of alcoholic liver disease in people from Lublin Region, eastern Poland.
Portal and parenchymal alterations of the liver in idiopathic portal hypertension: a histological and immunochemical study.
Liver Diseases
Association of functional gene polymorphisms of matrix metalloproteinase (MMP)-1, MMP-3 and MMP-9 with the progression of chronic liver disease.
Diagnostic potential of circulating TIMP-1 and MMP-2 as markers of liver fibrosis in patients with chronic hepatitis C.
Matrix metalloproteinase (MMP)-3 polymorphism in patients with HBV related chronic liver disease.
Non-canonical role of matrix metalloprotease (MMP) in activation and migration of hepatic stellate cells (HSCs).
Serum matrix metalloproteinase-1 in patients with chronic viral hepatitis.
Liver Diseases, Alcoholic
Activity of MMP-2, MMP-8 and MMP-9 in serum as a marker of progression of alcoholic liver disease in people from Lublin Region, eastern Poland.
Non-canonical role of matrix metalloprotease (MMP) in activation and migration of hepatic stellate cells (HSCs).
Liver Failure
Matrix metalloproteinase-9 in the initial injury after hepatectomy in mice.
Liver Failure, Acute
Chymase inhibition attenuates lipopolysaccharide/ d-galactosamine-induced acute liver failure in hamsters.
Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis.
Liver Neoplasms
Down-regulation of matrix-invasive potential of human liver cancer cells by type I interferon and a histone deacetylase inhibitor sodium butyrate.
Effects of matrix metalloproteinase inhibitor BB-94 on liver cancer growth and metastasis in a patient-like orthotopic model LCI-D20.
Hepatoma cell functions modulated by NEK2 are associated with liver cancer progression.
Knockdown of ACTA2?AS1 promotes liver cancer cell proliferation, migration and invasion.
Sonic Hedgehog signaling pathway induces cell migration and invasion through focal adhesion kinase/AKT signaling-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9 in liver cancer.
Lung Diseases
Effect of respiratory syncytial virus on the activity of matrix metalloproteinase in mice.
Implications for matrix metalloproteinases as modulators of pediatric lung disease.
Increased extracellular matrix metalloproteinase inducer (EMMPRIN) expression in pulmonary fibrosis.
Matrix metalloproteases in BAL fluid of patients with cystic fibrosis and their modulation by treatment with dornase alpha.
Matrix metalloproteinase-9 in lung remodeling.
Secretory leukocyte proteinase inhibitor and elafin are resistant to degradation by MMP-8.
Structural insights into the binding of MMP9 inhibitors.
Lung Diseases, Interstitial
Elevated matrilysin levels in bronchoalveolar lavage fluid do not distinguish idiopathic pulmonary fibrosis from other interstitial lung diseases.
Extracellular matrix metalloproteinase inducer in interstitial pneumonias.
Increased extracellular matrix metalloproteinase inducer (EMMPRIN) expression in pulmonary fibrosis.
Neutrophil collagenase in rheumatoid interstitial lung disease.
Serum matrix metalloproteinase levels in polymyositis/dermatomyositis patients with interstitial lung disease.
Lung Injury
Attenuation of oxidant-induced lung injury by the synthetic matrix metalloproteinase inhibitor BB-3103.
BPD Following Preterm Birth: A Model for Chronic Lung Disease and a Substrate for ARDS in Childhood.
Experimental hindlimb ischemia increases neutrophil-mediated matrix metalloproteinase activity: a potential mechanism for lung injury after limb ischemia.
Gene expressions and roles of matrix metalloproteinases-8 and tissue inhibitor of metalloproteinases-1 in hyperoxia-induced pulmonary fibrosis in neonatal rats.
High levels of extracellular matrix metalloproteinase inducer are expressed in lymphangioleiomyomatosis.
Inducible expression of tissue inhibitor of metalloproteinases-resistant matrix metalloproteinase-9 on the cell surface of neutrophils.
Induction of pulmonary matrilysin expression by combustion and ambient air particles.
Matrix metalloproteinases-2, -8, and -9 and TIMP-2 in tracheal aspirates from preterm infants with respiratory distress.
Mobilization of Bone Marrow Cells by CSF3 Protects Mice from Bleomycin-Induced Lung Injury.
Profibrotic Activities for Matrix Metalloproteinase-8 during Bleomycin-Mediated Lung Injury.
Resuscitation of hypoxic piglets with 100% O2 increases pulmonary metalloproteinases and IL-8.
Role of the SDF-1/CXCR4 axis in the pathogenesis of lung injury and fibrosis.
Selective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseases.
Shedding of Syndecan-1/CXCL1 Complexes by MMP7 Functions as an Epithelial Checkpoint of Neutrophil Activation.
Time-dependent inhibition of immune complex-induced lung injury by catalase: relationship to alterations in macrophage and neutrophil matrix metalloproteinase elaboration.
Type I collagenases in bronchoalveolar lavage fluid from preterm babies at risk of developing chronic lung disease.
Up-regulation of trypsin and mesenchymal MMP-8 during development of hyperoxic lung injury in the rat.
[Feature changes of MMP-2/9 activities and TIMP-1/2 protein expressions during the progression of pulmonary fibrosis in rats]
[Study on effect of dexamethasone on the expression of matrix metalloproteinase and its tissue inhibitors in hyperoxia-induced lung injury]
Lung Neoplasms
AKR1B10 (Aldo-keto reductase family 1 B10) promotes brain metastasis of lung cancer cells in a multi-organ microfluidic chip model.
Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios.
An orthotopic model of lung cancer to analyze primary and metastatic NSCLC growth in integrin alpha1-null mice.
Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer.
Andrographolide inhibits the activation of NF-?B and MMP-9 activity in H3255 lung cancer cells.
Anti-metastatic effects of isolinderalactone via the inhibition of MMP-2 and up regulation of NM23-H1 expression in human lung cancer A549 cells.
Anticancer effects of epigallocatechin-3-gallate nanoemulsion on lung cancer cells through the activation of AMP-activated protein kinase signaling pathway.
Association of matrix metalloproteinase family gene polymorphisms with lung cancer risk: logistic regression and generalized odds of published data.
Bcl-2 is an independent prognostic factor and adds to a biological model for predicting outcome in operable non-small cell lung cancer.
Bcl-X(L) and STAT3 mediate malignant actions of gamma-irradiation in lung cancer cells.
CCL25 promotes the migration and invasion of non-small cell lung cancer cells by regulating VEGF and MMPs in a CCR9-dependent manner.
Changes in angiogenic growth factor levels after gefitinib treatment in non-small cell lung cancer.
Comparative expression of matrix metalloproteinases in low-grade mucoepidermoid carcinoma and typical lung cancer.
Critical role and its underlying molecular events of the plasminogen receptor, S100A10 in malignant tumor and non-tumor diseases.
Curcumin inhibits lung cancer cell migration and invasion through Rac1-dependent signaling pathway.
Detection of circulating vascular endothelial growth factor and matrix metalloproteinase-9 in non-small cell lung cancer using Luminex multiplex technology.
Determination of the serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in patients with either advanced small-cell lung cancer or non-small-cell lung cancer prior to treatment.
Differential Expressions Of Matrix Metalloproteinases, A Disintegrin And Metalloproteinases, And A Disintegrin And Metalloproteinases With Thrombospondin Motifs And Their Endogenous Inhibitors Among Histologic Subtypes Of Lung Cancers.
Dysregulation of FURIN by prostaglandin-endoperoxide synthase 2 in lung epithelial NCI-H292 cells.
Early combined treatment with carboplatin and the MMP inhibitor, prinomastat, prolongs survival and reduces systemic metastasis in an aggressive orthotopic lung cancer model.
Efficient, enzyme responsive and tumor receptor targeting gelatin nanoparticles decorated with concanavalin-A for site-specific and controlled drug delivery for cancer therapy.
Expression and clinical significance of matrix metalloproteinase (MMP)-26 protein in non-small cell lung cancer.
Expression of a novel matrix metalloproteinase regulator, RECK, and its clinical significance in resected non-small cell lung cancer.
Expression of matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases in non-small-cell lung cancer.
Expression of metastasis-associated molecules in non-small cell lung cancer and their prognostic significance.
Feruloyl-L-arabinose attenuates migration, invasion and production of reactive oxygen species in H1299 lung cancer cells.
Gelatinolytic activity of matrix metalloproteinase in lung cancer studied using film in situ zymography stamp method.
Haplotypes in matrix metalloproteinase gene cluster on chromosome 11q22 contribute to the risk of lung cancer development and progression.
Hecogenin acetate inhibits reactive oxygen species production and induces cell cycle arrest and senescence in the A549 human lung cancer cell line.
High incidence of extracellular matrix metalloproteinase inducer expression in non-small cell lung cancers. Association with clinicopathological parameters.
How, with whom and when: an overview of CD147-mediated regulatory networks influencing matrix metalloproteinase activity.
IL-6 regulates MMP-10 expression via JAK2/STAT3 signaling pathway in a human lung adenocarcinoma cell line.
Increased expression of matrix metalloproteinase-2 (MMP-2) predicts tumour recurrence and unfavourable outcome in non-small cell lung cancer.
Inducible expression of tissue factor in small-cell lung cancer: impact on morphology and matrix metalloproteinase secretion.
Inhibition of lymphangiogenesis-related properties of murine lymphatic endothelial cells and lymph node metastasis of lung cancer by the matrix metalloproteinase inhibitor MMI270.
Matrix metalloproteinase 2/9-triggered-release micelles for inhaled drug delivery to treat lung cancer: preparation and in vitro/in vivo studies.
Matrix metalloproteinase activity in early-stage lung cancer.
Matrix metalloproteinase expression in lung cancer.
Matrix metalloproteinase family gene polymorphisms and lung cancer susceptibility: an updated meta-analysis.
Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression.
Matrix metalloproteinase inhibitor MMI-166 inhibits lymphogenous metastasis in an orthotopically implanted model of lung cancer.
Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses.
Matrix metalloproteinase polymorphisms and survival in stage I non-small cell lung cancer.
Matrix metalloproteinase-2 status in stromal fibroblasts, not in tumor cells, is a significant prognostic factor in non-small-cell lung cancer.
Matrix metalloproteinases and matrix metalloproteinase inhibitors in lung cancer.
Miltirone-induced apoptosis in cisplatin-resistant lung cancer cells through upregulation of p53 signaling pathways.
MMP7-mediated cleavage of nucleolin at Asp255 induces MMP9 expression to promote tumor malignancy.
Modulation of u-PA, MMPs and their inhibitors by a novel nutrient mixture in human lung cancer and mesothelioma cell lines.
Negative correlation of cytoplasm TIMP3 with miR-222 indicates a good prognosis for NSCLC.
NFV, an HIV-1 protease inhibitor, induces growth arrest, reduced Akt signalling, apoptosis and docetaxel sensitisation in NSCLC cell lines.
Non-invasive profiling of protease-specific elastin turnover in lung cancer: biomarker potential.
Organ heterogeneity of host-derived matrix metalloproteinase expression and its involvement in multiple-organ metastasis by lung cancer cell lines.
Overexpression of matrix metalloproteinase 2 predicts unfavorable outcome in early-stage non-small cell lung cancer.
Peonidin 3-glucoside inhibits lung cancer metastasis by downregulation of proteinases activities and MAPK pathway.
Phase I trial of Marimastat, a novel matrix metalloproteinase inhibitor, administered orally to patients with advanced lung cancer.
Phase I trial of the matrix metalloproteinase inhibitor marimastat combined with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer.
Phase III study of matrix metalloproteinase inhibitor prinomastat in non-small-cell lung cancer.
Pipoxolan inhibits CL1-5 lung cancer cells migration and invasion through inhibition of MMP-9 and MMP-2.
Pleural fluid analysis of lung cancer vs benign inflammatory disease patients.
Pretreatment vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) serum levels in patients with metastatic non-small cell lung cancer (NSCLC).
Prognostic impact of MMP-2 and MMP-9 expression in pathologic stage IA non-small cell lung cancer.
Randomized phase II feasibility study of combining the matrix metalloproteinase inhibitor BMS-275291 with paclitaxel plus carboplatin in advanced non-small cell lung cancer.
Randomized phase III study of matrix metalloproteinase inhibitor BMS-275291 in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: National Cancer Institute of Canada-Clinical Trials Group Study BR.18.
Redox regulation of matrix metalloproteinase gene family in small cell lung cancer cells.
Role of serum vascular endothelial growth factor in the prediction of angiogenesis and prognosis for non-small cell lung cancer.
Serum biomarkers reflecting specific tumor tissue remodeling processes are valuable diagnostic tools for lung cancer.
Serum matrix metalloproteinases -2, -9 and tissue inhibitors of metalloproteinases -1, -2 in lung cancer--TIMP-1 as a prognostic marker.
Small cell lung cancer and targeted therapies.
SNPs in matrix metalloproteinase genes and lung cancer chemotherapy response and prognosis.
Strategies to eradicate minimal residual disease in small cell lung cancer: high-dose chemotherapy with autologous bone marrow transplantation, matrix metalloproteinase inhibitors, and BEC2 plus BCG vaccination.
Study on Invadopodia Formation for Lung Carcinoma Invasion with a Microfluidic 3D Culture Device.
Targeting ?-tubulin/CCT-? complex induces apoptosis and suppresses migration and invasion of highly metastatic lung adenocarcinoma.
TGF-?-mediated exosomal lnc-MMP2-2 regulates migration and invasion of lung cancer cells to the vasculature by promoting MMP2 expression.
The Contribution of MMP-8 Promoter Polymorphisms in Lung Cancer.
The relationship of metalloproteinase gene polymorphisms and lung cancer.
Tissue inhibitor of metalloproteinase 3 suppresses tumor angiogenesis in matrix metalloproteinase 2-down-regulated lung cancer.
Transition from suspension to adherent growth is accompanied by tissue factor expression and matrix metalloproteinase secretion in a small cell lung cancer cell line.
Video-assisted thoracic surgery lobectomy for lung cancer is associated with less immunochemokine disturbances than thoracotomy.
[Effect of Src tyrosine kinase inhibition on secretion of MMP-2 and MMP-9 by non-small cell lung cancer cells].
[Expression and pathological mechanism of MMP-9 and HIF-2? in CD133(+) lung cancer stem cells].
[Expression and significance of MIF and CD147 in non-small cell lung cancer]
[Expression of adiponectin in non-small cell lung cancer and its relationship with MMP-9 and angiogenesis].
[MiR-373-3p Promotes Invasion and Metastasis of Lung Adenocarcinoma Cells].
[Molecular therapy in lung cancer]
[Significance of caveolin-1 protein detected by quantum dots technique in human lung cancer invasiveness and metastasis.]
Lupus Erythematosus, Cutaneous
Ultraviolet radiation-induced cytokines promote mast cell accumulation and matrix metalloproteinase production: potential role in cutaneous lupus erythematosus.
Lupus Erythematosus, Systemic
Concentrations of circulating matrix metalloproteinase 9 inversely correlate with autoimmune antibodies to double stranded DNA: implications for monitoring disease activity in systemic lupus erythematosus.
Lupus Nephritis
Increased glomerular matrix metalloproteinase activity in murine lupus nephritis.
Lyme Neuroborreliosis
Detection of a 130-kD matrix metalloproteinase in cerebrospinal fluid from a patient with Lyme neuroborreliosis.
Lymphangioleiomyomatosis
Doxycycline use in patients with lymphangioleiomyomatosis: biomarkers and pulmonary function response.
Doxycycline use in patients with lymphangioleiomyomatosis: safety and efficacy in metalloproteinase blockade.
High levels of extracellular matrix metalloproteinase inducer are expressed in lymphangioleiomyomatosis.
Rapamycin-insensitive Up-regulation of MMP2 and Other Genes in TSC2-deficient LAM-like Cells.
Lymphatic Metastasis
Association between expression of MMP-7 and MMP-9 and pelvic lymph node and para-aortic lymph node metastasis in early cervical cancer.
Association between immunohistochemical expression of matrix metalloproteinases and metastasis in oral squamous cell carcinoma: Systematic review and meta-analysis.
Association of CD44 V3-containing isoforms with tumor cell growth, migration, matrix metalloproteinase expression, and lymph node metastasis in head and neck cancer.
Clinicopathological features and overexpression of matrix metalloproteinases in intramucosal gastric carcinoma with lymph node metastasis.
Correlation between expression of extracellular matrix metalloproteinase inducer and matrix metalloproteinase-2 and cervical lymph node metastasis of nasopharyngeal carcinoma.
Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer.
Immunohistochemical levels of matrix metalloproteinase-2 and CD44 variant 6 protein in the diagnosis and lateral cervical lymph node metastasis of papillary thyroid carcinoma.
Inhibition of invasion and lymph node metastasis of gastrointestinal cancer cells by R-94138, a matrix metalloproteinase inhibitor.
Inhibition of lymphangiogenesis-related properties of murine lymphatic endothelial cells and lymph node metastasis of lung cancer by the matrix metalloproteinase inhibitor MMI270.
Involvement of inactive GSK3beta overexpression in tumorigenesis and progression of gastric carcinomas.
LABAZ1: A metastatic tumor model for renal cell carcinoma expressing the carbonic anhydrase type 9 tumor antigen.
Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion.
Prognostic significance of matrix metalloproteinase-20 overexpression in laryngeal squamous cell carcinoma.
Recombination of CXCR4, VEGF, and MMP-9 predicting lymph node metastasis in human breast cancer.
Study on extracellular matrix metalloproteinase inducer and human epidermal growth factor receptor-2 protein expression in papillary thyroid carcinoma using a quantum dot-based immunofluorescence technique.
The inhibitory effect of matrix metalloproteinase inhibitor ONO-4817 on lymph node metastasis in tongue carcinoma.
[Relationship between lymph node metastasis and the expressions of E-cadherin, N-cadherin, and matrix metalloproteinase in breast carcinoma]
[Role of matrix metalloproteinase (MMP)-2 and -9 and vascular endothelial growth factor C in lymph node metastasis of breast cancer.]
Lymphoma
Accelerated fibrosis and apoptosis with ageing and in atrial fibrillation: Adaptive responses with maladaptive consequences.
Alpinetin inhibits proliferation and migration of ovarian cancer cells via suppression of STAT3 signaling.
Analysis of ALK, IDH1, IDH2 and MMP8 somatic mutations in differentiated thyroid cancers.
CTHRC1 mediates IL?1??induced apoptosis in chondrocytes via JNK1/2 signaling.
Evaluation of extracellular matrix protein expression and apoptosis in the uterosacral ligaments of patients with or without pelvic organ prolapse.
Expression of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) in tissues with a diagnosis of childhood lymphoma.
Inhibitory effects of FKBP14 on human cervical cancer cells.
Interleukin-6 regulation of matrix metalloproteinase (MMP-2 and MMP-9) and tissue inhibitor of metalloproteinase (TIMP-1) expression in malignant non-Hodgkin's lymphomas.
MicroRNA?15a?5p induces pulmonary artery smooth muscle cell apoptosis in a pulmonary arterial hypertension model via the VEGF/p38/MMP?2 signaling pathway.
Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.
Protective effects of psoralidin on IL?1??induced chondrocyte apoptosis.
Punicalagin suppresses the proliferation and invasion of cervical cancer cells through inhibition of the ?-catenin pathway.
Stromelysin-2 (matrix metalloproteinase 10) is inducible in lymphoma cells and accelerates the growth of lymphoid tumors in vivo.
Type II cGMP?dependent protein kinase inhibits the migration, invasion and proliferation of several types of human cancer cells.
Lymphoma, B-Cell
Accelerated fibrosis and apoptosis with ageing and in atrial fibrillation: Adaptive responses with maladaptive consequences.
Effects of a nutrient mixture on immunohistochemical localization of cancer markers in human cervical cancer HeLa cell tumor xenografts in female nude mice.
Evaluation of extracellular matrix protein expression and apoptosis in the uterosacral ligaments of patients with or without pelvic organ prolapse.
Functions of endothelin-1 in apoptosis and migration in hepatocellular carcinoma.
Human colon carcinogenesis is associated with increased interleukin-17-driven inflammatory responses.
I157172, a novel inhibitor of cystathionine ?-lyase, inhibits growth and migration of breast cancer cells via SIRT1-mediated deacetylation of STAT3.
Long intergenic noncoding RNA LINC00284 knockdown reduces angiogenesis in ovarian cancer cells via up-regulation of MEST through NF-?B1.
Miltirone-induced apoptosis in cisplatin-resistant lung cancer cells through upregulation of p53 signaling pathways.
miR-30d inhibits cell biological progression of Ewing's sarcoma by suppressing the MEK/ERK and PI3K/Akt pathways
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Puerarin 6?-O-xyloside possesses significant antitumor activities on colon cancer through inducing apoptosis.
Trametes robiniophila may induce apoptosis and inhibit MMPs expression in the human gastric carcinoma cell line MKN-45.
Treadmill exercise ameliorates impairment of spatial learning memory in pups born to old and obese mother rats.
Wnt6 contributes tumorigenesis and development of colon cancer via its effects on cell proliferation, apoptosis, cell-cycle and migration.
Lymphoma, T-Cell
Increase in gelatinase-specificity of matrix metalloproteinase inhibitors correlates with antimetastatic efficacy in a T-cell lymphoma model.
Macular Degeneration
Bone marrow-derived mesenchymal cells and MMP13 contribute to experimental choroidal neovascularization.
Disturbed matrix metalloproteinase activity of Bruch's membrane in age-related macular degeneration.
Disturbed Matrix Metalloproteinase Pathway in Both Age-Related Macular Degeneration and Alzheimer's Disease.
Increase in interphotoreceptor matrix gelatinase A (MMP-2) associated with age-related macular degeneration.
Risk of macular degeneration affected by polymorphisms in Matrix metalloproteinase-2: A case-control study in Chinese Han population.
The association of matrix metalloproteinases polymorphisms and interleukins in advanced age-related macular degeneration.
Understanding the complexity of the matrix metalloproteinase system and its relevance to age-related diseases: Age-related macular degeneration and Alzheimer's disease.
Macular Edema
Matrix Metalloproteinase-1 and Matrix Metalloproteinase-9 in the Aqueous Humor of Diabetic Macular Edema Patients.
Malaria
Matrix metalloproteinase-9 polymorphism 1562 C > T (rs3918242) associated with protection against placental malaria.
Matrix Metalloproteinases and Their Tissue Inhibitors (TIMPs) in Plasmodium falciparum Malaria: Serum Levels of TIMP-1 Are Associated with Disease Severity.
Matrix metalloproteinases and their tissue inhibitors (TIMPs) in Plasmodium falciparum malaria: serum levels of TIMP-1 are associated with disease severity.
Malaria, Cerebral
Glial activation and matrix metalloproteinase release in cerebral malaria.
Malnutrition
The expression of matrix metalloproteinases 8 and 9 by neutrophils of Wistar albino rats with severe qualitative and quantitative protein malnutrition.
Marfan Syndrome
Long-term doxycycline is more effective than atenolol to prevent thoracic aortic aneurysm in marfan syndrome through the inhibition of matrix metalloproteinase-2 and -9.
Long-term effects of losartan on structure and function of the thoracic aorta in a mouse model of Marfan syndrome.
RGD-containing fibrillin-1 fragments upregulate matrix metalloproteinase expression in cell culture: a potential factor in the pathogenesis of the Marfan syndrome.
Ulnar Artery Aneurysm as a Late Sequela of Marfan Syndrome.
Mastitis
Altered Leukocyte Responsiveness in Dairy Cows with Naturally Occurring Chronic Staphylococcus aureus Mastitis.
Increase in milk metalloproteinase activity and vascular permeability in bovine endotoxin-induced and naturally occurring Escherichia coli mastitis.
Mastocytoma
Dog mastocytoma cells secrete a 92-kD gelatinase activated extracellularly by mast cell chymase.
Medulloblastoma
Blockade of tumor growth due to matrix metalloproteinase-9 inhibition is mediated by sequential activation of beta1-integrin, ERK, and NF-kappaB.
Extracellular Matrix Metalloproteinase Inducer is a Negative Prognostic Factor of Pediatric Medulloblastoma.
Protein expression of matrix metalloproteinase (MMP-1, -2, -3, -9 and -14) in Ewing family tumors and medulloblastomas of pediatric patients.
Melanoma
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces matrix metalloproteinase (MMP) expression and invasion in A2058 melanoma cells.
A natural bacterial-derived product, the metalloprotease arazyme, inhibits metastatic murine melanoma by inducing MMP-8 cross-reactive antibodies.
A novel interaction between calcium-modulating cyclophilin ligand and Basigin regulates calcium signaling and matrix metalloproteinase activities in human melanoma cells.
Adhesive defect in extracellular matrix tenascin-X-null fibroblasts: a possible mechanism of tumor invasion.
Analysis of Enzymatic Activity of Matrix Metalloproteinase (MMP) by Collagen Zymography in Melanoma.
Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma.
Anti-tumor angiogenic effect of a matrix metalloproteinase inhibitor MMI270.
Assaying Wnt5A-mediated invasion in melanoma cells.
Astrocytes facilitate melanoma brain metastasis via secretion of IL-23.
Augmented growth inhibition of B16-BL6 melanoma by combined treatment with a selective matrix metalloproteinase inhibitor, MMI-166, and cytotoxic agents.
Benefit of adjuvant interferon alfa-2b (IFN-?) therapy in melanoma patients with high serum MMP-8 levels.
Clarithromycin and dexamethasone show similar anti-inflammatory effects on distinct phenotypic chronic rhinosinusitis: an explant model study.
Comparison of the prognostic value of matrix metalloproteinases 2 and 9 in cutaneous melanoma.
Critical role for matrix metalloproteinase-9 in platelet-activating factor-induced experimental tumor metastasis.
Differential expression of matrix metalloproteinase-2 by fibroblasts in co-cultures with keratinocytes, basal cell carcinoma and melanoma.
Direct and tumor microenvironment mediated influences of 5'-deoxy-5'-(methylthio)adenosine on tumor progression of malignant melanoma.
Evaluation of EMMPRIN and MMP-2 in the prognosis of primary cutaneous malignant melanoma.
Exposure of the cryptic de-adhesive site FNIII14 in fibronectin molecule and its binding to membrane-type eEF1A induce migration and invasion of cancer cells via ?1-integrin inactivation.
Expression and Characterization of Membrane-Type 4 Matrix Metalloproteinase (MT4-MMP) and its Different Forms in Melanoma.
Expression of matrix metalloproteinase (MMP)-2, MMP-9, and tissue inhibitor of MMP (TIMP)-1 in conjunctival melanomas and clinical implications.
Expression of matrix metalloproteinase-2 and -9 and membrane-type 1 matrix metalloproteinase in melanocytic tumors of dogs and canine melanoma cell lines.
Expression of vascular endothelial growth factor a, matrix metalloproteinase 9 and extravascular matrix patterns in iris and ciliary body melanomas.
Glycoprotein non-metastatic melanoma protein B promotes glioma motility and angiogenesis through the Wnt/?-catenin signaling pathway.
Gonadotropin-releasing hormone agonists suppress melanoma cell motility and invasiveness through the inhibition of alpha3 integrin and MMP-2 expression and activity.
Helix aspersa maxima mucus exhibits antimelanogenic and antitumoral effects against melanoma cells.
IL-33/ST2 Axis Regulates Vasculogenic Mimicry via ERK1/2-MMP-2/9 Pathway in Melanoma.
Immunohistochemical expression of matrix metalloproteinase-2 and -9 in melanocytic nevi is altered by ultraviolet B.
Induction of matrix metalloproteinase gene transcription by nitric oxide and mechanisms of MMP-1 gene induction in human melanoma cell lines.
Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference.
Inhibition of the metastatic spread and growth of B16-BL6 murine melanoma by a synthetic matrix metalloproteinase inhibitor.
Matrix metalloproteinase expression in malignant melanomas: tumor-extracellular matrix interactions in invasion and metastasis.
Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion.
Matrix metalloproteinases in human melanoma cell lines and xenografts: increased expression of activated matrix metalloproteinase-2 (MMP-2) correlates with melanoma progression.
Matrix metalloproteinases in human melanoma.
MDA-9/syntenin: a positive gatekeeper of melanoma metastasis.
Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen.
Modulated Electro-Hyperthermia Facilitates NK-Cell Infiltration and Growth Arrest of Human A2058 Melanoma in a Xenograft Model.
Modulation of Activated Leukocyte Cell Adhesion Molecule-Mediated Invasion Triggers an Innate Immune Gene Response in Melanoma.
Molecular profiling related to poor prognosis in thyroid carcinoma. Combining gene expression data and biological information.
Mycobacterium indicus pranii (Mw) inhibits invasion by reducing matrix metalloproteinase (MMP-9) via AKT/ERK-1/2 and PKC? signalling: a potential candidate in melanoma cancer therapy.
Neutrophil collagenase (MMP-8) is expressed during early development in neural crest cells as well as in adult melanoma cells.
Nifuroxazide exerts potent anti-tumor and anti-metastasis activity in melanoma.
Noncanonical Activation of Notch1 Protein by Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Controls Melanoma Cell Proliferation.
Notch1-MAPK Signaling Axis Regulates CD133(+) Cancer Stem Cell-Mediated Melanoma Growth and Angiogenesis.
Phase II study of marimastat (BB-2516) in malignant melanoma: a clinical and tumor biopsy study of the National Cancer Institute of Canada Clinical Trials Group.
Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis.
Potentiated antitumor effects of interleukin 12 and matrix metalloproteinase inhibitor batimastat against B16F10 melanoma in mice.
Prognostic significance of phosphorylated signal transducer and activator of transcription 3 and suppressor of cytokine signaling 3 expression in human cutaneous melanoma.
Recent advances in melanoma research.
Recombinant human prothrombin kringle-2 inhibits B16F10 melanoma metastasis through inhibition of neovascularization and reduction of matrix metalloproteinase expression.
Recombinant snake venom metalloproteinase inhibitor BJ46A inhibits invasion and metastasis of B16F10 and MHCC97H cells through reductions of matrix metalloproteinases 2 and 9 activities.
Role of ING4 in human melanoma cell migration, invasion and patient survival.
RSK1 Activation Promotes Invasion in Nodular Melanoma.
S100 Soil Sensor Receptors and Molecular Targeting Therapy Against Them in Cancer Metastasis.
Serum biomarkers reflecting specific tumor tissue remodeling processes are valuable diagnostic tools for lung cancer.
Serum matrix metalloproteinase-8 is associated with ulceration and vascular invasion of malignant melanoma.
Silymarin Targets ?-Catenin Signaling in Blocking Migration/Invasion of Human Melanoma Cells.
Soluble biomarkers of cartilage and bone metabolism in early proof of concept trials in psoriatic arthritis: effects of adalimumab versus placebo.
Targeting of BRAF resistant melanoma via extracellular matrix metalloproteinase inducer receptor.
Targeting the PI3K/AKT/mTOR pathway overcomes the stimulating effect of dabrafenib on the invasive behavior of melanoma cells with acquired resistance to the BRAF inhibitor.
TGF-? signaling, activated stromal fibroblasts, and cysteine cathepsins B and L drive the invasive growth of human melanoma cells.
The effect of ultraviolet radiation on choroidal melanocytes and melanoma cell lines: cell survival and matrix metalloproteinase production.
The Ezh2 polycomb group protein drives an aggressive phenotype in melanoma cancer stem cells and is a target of diet derived sulforaphane.
The fibrinolytic factor tPA drives LRP1-mediated melanoma growth and metastasis.
The herbal medicine Sho-saiko-to inhibits growth and metastasis of malignant melanoma primarily developed in ret-transgenic mice.
The matrix metalloproteinase inhibitor batimastat inhibits angiogenesis in liver metastases of B16F1 melanoma cells.
The Melanoma Vascular Mimicry Phenotype Defined in Gene Expression and Microsome Sequencing Analysis.
The phosphorylation of CD147 by Fyn plays a critical role for melanoma cells growth and metastasis.
Therapeutic intervention of proanthocyanidins on the migration capacity of melanoma cells is mediated through PGE2 receptors and ?-catenin signaling molecules.
TIMP-2: identification and characterization of a new member of the metalloproteinase inhibitor family.
Tissue inhibitor of metalloproteinase (TIMP-2). A new member of the metalloproteinase inhibitor family.
Up-regulating ribonuclease inhibitor inhibited epithelial-to-mesenchymal transition and metastasis in murine melanoma cells.
Uveal melanocytes express high constitutive levels of MMP-8 which can be upregulated by TNF-? via the MAPK pathway.
Vemurafenib resistance increases melanoma invasiveness and modulates the tumor microenvironment by MMP-2 upregulation.
Wild-type versus mutant MMP-8 in melanoma: 'When you come to a fork in the road, take it'*
[Non-specific immunotherapy inhibits angiogenesis - results of the monitoring of serum levels of vascular endothelial growth factor and matrix metalloproteinase 8 in patients with malignant melanoma receiving adjuvant high-dose interferon therapy].
Melanoma, Experimental
Matrix metalloproteinase induction in the tumor stroma does not depend on CD147 expression in murine B16 melanoma.
Matrix metalloproteinase inhibitor, MMI270 (CGS27023A) inhibited hematogenic metastasis of B16 melanoma cells in both experimental and spontaneous metastasis models.
Meningeal Carcinomatosis
Specific matrix metalloproteinase profiles in the cerebrospinal fluid correlated with the presence of malignant astrocytomas, brain metastases, and carcinomatous meningitis.
Meningioma
Matrix metalloproteinases in human gliomas: activation of matrix metalloproteinase-2 (MMP-2) may be correlated with membrane-type-1 matrix metalloproteinase (MT1-MMP) expression.
Possible role of matrix metalloproteinase in osteolytic intracranial meningiomas.
The role of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinase in microcystic meningiomas.
Meningitis
A case of idiopathic hypertrophic cranial pachymeningitis presenting high values of matrix metalloproteinase.
Chemokines and matrix metalloproteinases in cerebrospinal fluid of patients with central nervous system complications caused by varicella-zoster virus.
Current concepts in the pathogenesis of meningitis caused by Streptococcus pneumoniae.
Dynamic changes of matrix metalloproteinase-9 in patients with Klebsiella pneumoniae meningitis.
Effects of purulent meningitis on the changes of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase inhibitor-1 (TIMP-1) in cerebrospinal fluid of neonates.
Human parasitic meningitis caused by Angiostrongylus cantonensis infection in Taiwan.
Meningitis, Aseptic
Persistent increase of matrix metalloproteinases in cerebrospinal fluid of tuberculous meningitis.
Meningitis, Bacterial
Matrix metalloproteinase (MMP)-8 and MMP-9 in cerebrospinal fluid during bacterial meningitis: association with blood-brain barrier damage and neurological sequelae.
The Potential Role of Matrix Metalloproteinases 8 and 9 and Myeloperoxidase in Predicting Outcomes of Bacterial Meningitis of Childhood.
Meningitis, Pneumococcal
Dexamethasone regulation of matrix metalloproteinase expression in experimental pneumococcal meningitis.
Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis.
Matrix metalloproteinase inhibition lowers mortality and brain injury in experimental pneumococcal meningitis.
The matrix metalloproteinase inhibitor RS-130830 attenuates brain injury in experimental pneumococcal meningitis.
Meningococcal Infections
Neisseria meningitidis induces brain microvascular endothelial cell detachment from the matrix and cleavage of occludin: a role for MMP-8.
Meningoencephalitis
Matrix metalloproteinase expression in sheep with listerial meningoencephalitis.
Menorrhagia
Reduced levels of VEGF-A and MMP-2 and MMP-9 activity and increased TNF-alpha in menstrual endometrium and effluent in women with menorrhagia.
Mesothelioma, Malignant
Adenosine diphosphate regulates MMP2 and MMP9 activity in malignant mesothelioma cells.
Expression of Snail, Slug and Sip1 in malignant mesothelioma effusions is associated with matrix metalloproteinase, but not with cadherin expression.
Inhibition of malignant mesothelioma cell matrix metalloproteinase production and invasion by a novel nutrient mixture.
Modulation of u-PA, MMPs and their inhibitors by a novel nutrient mixture in human lung cancer and mesothelioma cell lines.
Slug enhances invasion ability of pancreatic cancer cells through upregulation of matrix metalloproteinase-9 and actin cytoskeleton remodeling.
Metabolic Diseases
Cleavage and reduced CD36 ectodomain density on heart and spleen macrophages in the spontaneously hypertensive rat.
Metabolic Syndrome
Correlates of serum matrix metalloproteinase-8 (MMP-8) concentrations in nondiabetic subjects without cardiovascular disease.
Evaluation of plasma MMP-8, MMP-9 and TIMP-1 identifies candidate cardiometabolic risk marker in metabolic syndrome: results from double-blinded nested case-control study.
Genetic variants of matrix metalloproteinase (MMP2) gene influence metabolic syndrome susceptibility.
Impaired coronary collateral growth in the metabolic syndrome is in part mediated by matrix metalloproteinase 12-dependent production of endostatin and angiostatin.
Increased circulating levels of matrix metalloproteinase (MMP)-8, MMP-9, and pro-inflammatory markers in patients with metabolic syndrome.
Interaction between Vascular Endothelial Growth Factor-A (rs2010963) Gene Polymorphisms and Dietary Diversity Score on Cardiovascular Risk Factors in Patients with Metabolic Syndrome.
The MMP-9 -1562 C/T polymorphism in the presence of metabolic syndrome increases the risk of clinical events in patients with coronary artery disease.
Validation of Periodontitis Screening Model Using Socio-Demographic, Systemic and Molecular Information in a Korean Population.
Metrorrhagia
Endometrial histology, microvascular density and caliber, and matrix metalloproteinase-3 in users of the Nestorone-releasing contraceptive implant with and without endometrial breakthrough bleeding.
Enhanced expressions of matrix metalloproteinase (MMP)-2 and -9 and vascular endothelial growth factors (VEGF) and increased microvascular density in the endometrial hyperplasia of women with anovulatory dysfunctional uterine bleeding.
Migraine Disorders
45(th) Annual Scientific Meeting of the American Headache Society June 19 -22, 2003, Chicago, IL, USA.
Combined effects of ACE and MMP-3 polymorphisms on migraine development.
Different circulating metalloproteinases profiles in women with migraine with and without aura.
Increased matrix metalloproteinase activity is associated with migraine and migraine-related metabolic dysfunctions.
Matrix metalloproteinase (MMP)-2 gene polymorphisms affect circulating MMP-2 levels in patients with migraine with aura.
Migraine with Aura
Matrix metalloproteinase (MMP)-2 gene polymorphisms affect circulating MMP-2 levels in patients with migraine with aura.
Mitral Valve Insufficiency
Cardiac mast cell- and chymase-mediated matrix metalloproteinase activity and left ventricular remodeling in mitral regurgitation in the dog.
Mouth Neoplasms
Antisense E1AF transfection restrains oral cancer invasion by reducing matrix metalloproteinase activities.
Assessment of MicroRNA (miR)-365 Effects on Oral Squamous Carcinoma Cell Line Phenotypes.
Association of overexpressed karyopherin alpha 2 with poor survival and its contribution to interleukin-1?-induced matrix metalloproteinase expression in oral cancer.
Effects of cytokines on matrix metalloproteinase expression in oral squamous cell carcinoma in vitro.
Gelatinolytic activity of matrix metalloproteinase in tumor tissues correlates with the invasiveness of oral cancer.
Matrix Metalloproteinase 20-Dentin Sialophosphoprotein Interaction in Oral Cancer.
Matrix metalloproteinase gene polymorphisms and oral cancer.
Matrix metalloproteinases (MMPs) in oral diseases.
Overexpression of Translocation Associated Membrane Protein 2 Leading to Cancer-Associated Matrix Metalloproteinase Activation as a Putative Metastatic Factor for Human Oral Cancer.
Slug is a downstream mediator of transforming growth factor-beta1-induced matrix metalloproteinase-9 expression and invasion of oral cancer cells.
The Contribution of Matrix Metalloproteinase-8 Promoter Polymorphism to Oral Cancer Susceptibility.
The matrix metalloproteinase and insulin-like growth factor system in oral cancer - a prospective clinical study.
Moyamoya Disease
MMP-9 as a Biomarker for Predicting Hemorrhagic Strokes in Moyamoya Disease.
Mucocele
Significant correlation between matrix metalloproteinase activity and tumor necrosis factor-alpha in salivary extravasation mucoceles.
Mucocutaneous Lymph Node Syndrome
Cell distribution differences of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in patients with kawasaki disease.
Effect of angiotensin-converting enzyme inhibitor on matrix metalloproteinase-9 activity in patients with Kawasaki disease.
Matrix metalloproteinase haplotypes associated with coronary artery aneurysm formation in patients with Kawasaki disease.
[Roles of matrix metalloproteinases, tissue inhibitor of matrix metalloproteinase and hs-CRP in Kawasaki disease]
Mucositis
Evaluation of Metalloproteinase-8 Levels in Crevicular Fluid of Patients with Healthy Implants or Periodontitis.
Histological evaluation of peri-implant mucosal and gingival tissues in peri-implantitis, peri-implant mucositis and periodontitis patients: a cross-sectional clinical study.
Use of IL-1 ?, IL-6, TNF-?, and MMP-8 biomarkers to distinguish peri-implant diseases: A systematic review and meta-analysis.
Multiple Myeloma
Increased expression of extracellular matrix metalloproteinase inducer (CD147) in multiple myeloma: role in regulation of myeloma cell proliferation.
Matrix metalloproteinase and cytokine production by bone marrow adherent cells from multiple myeloma patients.
Resveratrol as a novel agent for treatment of multiple myeloma with matrix metalloproteinase inhibitory activity.
Systemic levels of interleukin-6 and matrix metalloproteinase-9 in patients with multiple myeloma may be useful as prognostic indexes of bone disease.
Tumor-associated macrophages and extracellular matrix metalloproteinase inducer in prognosis of multiple myeloma.
Multiple Sclerosis
Alterations in serum MMP-8, MMP-9, IL-12p40 and IL-23 in multiple sclerosis patients treated with interferon-beta1b.
Altered expression of the plasminogen activation pathway in peripheral blood mononuclear cells in multiple sclerosis: possible pathomechanism of matrix metalloproteinase activation.
An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization.
Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis.
Collagenase-2 deficiency or inhibition impairs experimental autoimmune encephalomyelitis in mice.
Differential matrix metalloproteinase expression in cases of multiple sclerosis and stroke.
Effect of interferon beta-1a on serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) in relapsing remitting multiple sclerosis patients. One year follow-up results.
Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors.
Evaluation of matrix metalloproteinase-9 plasma levels in untreated new Relapsing-remitting multiple sclerosis patients and their first-degree family.
Expression and regulation of matrix metalloproteinase-12 in experimental autoimmune encephalomyelitis and by bone marrow derived macrophages in vitro.
Extracellular matrix metalloproteinase inducer shows active perivascular cuffs in multiple sclerosis.
Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier.
Immobilization of matrix metalloproteinase 8 (MMP-8) for online drug screening.
Impact of Minocycline on Extracellular Matrix Metalloproteinase Inducer, a Factor Implicated in Multiple Sclerosis Immunopathogenesis.
Increased expression ratio of matrix metalloproteinase-9 (MMP9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) RNA levels in Iranian multiple sclerosis patients.
Inhibitory Effect of Polyunsaturated Fatty Acids on MMP-9 Release from Microglial Cells-Implications for Complementary Multiple Sclerosis Treatment.
Insight towards the conserved water mediated recognition of catalytic and structural Zn(+2) ions in human Matrix Metalloproteinase-8 enzyme: A study by MD-simulation methods.
Localization of near-infrared labeled antibodies to the central nervous system in experimental autoimmune encephalomyelitis.
Matrix metalloproteinase expression in an experimentally-induced DTH model of multiple sclerosis in the rat CNS.
Matrix metalloproteinase proteolysis of the myelin basic protein isoforms is a source of immunogenic peptides in autoimmune multiple sclerosis.
Matrix metalloproteinase-12 deficiency worsens relapsing-remitting experimental autoimmune encephalomyelitis in association with cytokine and chemokine dysregulation.
Misuse of serum matrix metalloproteinase (MMP)-9 and tissue inhibitor of metalloproteinase (TIMP)-1 as a biomarker in multiple sclerosis.
MMP-2 -1575G/A polymorphism modifies the onset of optic neuritis as a first presenting symptom in MS?
Once-weekly 22microg subcutaneous IFN-beta-1a in secondary progressive MS: a 3-year follow-up study on brain MRI measurements and serum MMP-9 levels.
PEG minocycline-liposomes ameliorate CNS autoimmune disease.
Serum MMP-2 and MMP-9 are elevated in different multiple sclerosis subtypes.
Multiple Sclerosis, Chronic Progressive
Once-weekly 22microg subcutaneous IFN-beta-1a in secondary progressive MS: a 3-year follow-up study on brain MRI measurements and serum MMP-9 levels.
Multiple Sclerosis, Relapsing-Remitting
Dynamic changes of MMP-9 plasma levels correlate with JCV reactivation and immune activation in natalizumab-treated multiple sclerosis patients.
Effect of interferon beta-1a on serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) in relapsing remitting multiple sclerosis patients. One year follow-up results.
Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) in patients with relapsing-remitting multiple sclerosis treated with interferon beta.
Multiple System Atrophy
Region-Specific Alterations of Matrix Metalloproteinase Activity in Multiple System Atrophy.
Muscular Atrophy
The mechanisms and treatments of muscular pathological changes in immobilization-induced joint contracture: A literature review.
Muscular Disorders, Atrophic
Matrix metalloproteinase imbalance in muscle disuse atrophy.
Muscular Dystrophies
Congenital Muscular Dystrophy 1D Causes Matrix Metalloproteinase Activation And Blood-Brain Barrier Impairment.
Muscular Dystrophy, Duchenne
Mitochondrial dysfunction causes Ca2+ overload and ECM degradation-mediated muscle damage in C. elegans.
Myalgia
A phase I and pharmacologic study of the matrix metalloproteinase inhibitor CP-471,358 in patients with advanced solid tumors.
Myelodysplastic Syndromes
Increased intracellular activity of matrix metalloproteinases in neutrophils may be associated with delayed healing of infection without neutropenia in myelodysplastic syndromes.
Matrix metalloproteinase production by bone marrow mononuclear cells from normal individuals and patients with acute and chronic myeloid leukemia or myelodysplastic syndromes.
Myocardial Infarction
Acute Myocardial Infarction is Reflected in Salivary Matrix Metalloproteinase-8 Activation Level.
Aliskiren and valsartan mediate left ventricular remodeling post-myocardial infarction in mice through MMP-9 effects.
Alteplase treatment affects circulating matrix metalloproteinase concentrations in patients with ST segment elevation acute myocardial infarction.
Analysis of protein fragmentation inhibition by an MMP-inhibitor in an in vivo model of heart failure using automated chromatography.
Association of R279Q and C1562T polymorphisms of matrix metalloproteinase 9 gene and increased risk for myocardial infarction in patients with premature coronary artery disease.
Attenuation of lipid metabolic abnormalities, proinflammatory cytokines, and matrix metalloproteinase expression by biochanin-A in isoproterenol-induced myocardial infarction in rats.
Bilateral sympathectomy improves postinfarction left ventricular remodeling and function.
Cell-based gene therapy modifies matrix remodeling after a myocardial infarction in tissue inhibitor of matrix metalloproteinase-3-deficient mice.
Changes of Matrix Metalloproteinase-9 Level Is Associated With Left Ventricular Remodeling Following Acute Myocardial Infarction Among Patients Treated With Trandolapril, Valsartan or Both.
Chronic matrix metalloproteinase inhibition following myocardial infarction in mice: differential effects on short and long-term survival.
Circulating level of gelatinase activity predicts ventricular remodeling in patients with acute myocardial infarction.
Circulating pregnancy-associated plasma protein a predicts outcome in patients with acute coronary syndrome but no troponin I elevation.
Clinical trials update from the American College of Cardiology meeting: CARE-HF and the remission of heart failure, Women's Health Study, TNT, COMPASS-HF, VERITAS, CANPAP, PEECH and PREMIER.
Comparison of vasopeptidase inhibitor omapatrilat and angiotensin receptor blocker candesartan on extracellular matrix, myeloperoxidase, cytokines, and ventricular remodeling during healing after reperfused myocardial infarction.
Doxycycline ameliorates ischemic and border-zone remodeling and endothelial dysfunction after myocardial infarction in rats.
Dynamic expression of the main related indicators of thrombosis, inflammatory reaction and tissue damage in a rat model of myocardial infarction.
Effect of matrix metalloproteinase inhibition by doxycycline on myocardial healing and remodeling after myocardial infarction.
Effect of modified glucose-insulin-potassium on free fatty acids, matrix metalloproteinase, and myoglobin in ST-elevation myocardial infarction.
Effects of mesenchymal stem cells on matrix metalloproteinase synthesis in cardiac fibroblasts.
Effects of selective matrix metalloproteinase inhibitor (PG-116800) to prevent ventricular remodeling after myocardial infarction: results of the PREMIER (Prevention of Myocardial Infarction Early Remodeling) trial.
Elevation of plasma matrix metalloproteinase-9 in the culprit coronary artery in patients with acute myocardial infarction: clinical evidence from distal protection.
EMMPRIN-Targeted Magnetic Nanoparticles for In Vivo Visualization and Regression of Acute Myocardial Infarction.
Enhanced T-cell expression of RANK ligand in acute coronary syndrome: possible role in plaque destabilization.
Erratum: "Acute Myocardial Infarction is Reflected in Salivary Matrix Metalloproteinase-8 Activation Level".
Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat.
Extracellular matrix metalloproteinase inducer (EMMPRIN) is increased in human left ventricle after acute myocardial infarction.
Extracellular matrix metalloproteinase inducer (EMMPRIN), acute myocardial infarction and the Kounis syndrome.
Extracellular matrix metalloproteinase inducer regulates matrix metalloproteinase activity in cardiovascular cells: implications in acute myocardial infarction.
Fibrosis of the left atria during progression of heart failure is associated with increased matrix metalloproteinases in the rat.
Fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, attenuates left ventricular remodeling and failure after experimental myocardial infarction.
Gingival crevicular fluid MMP-8-concentrations in patients after acute myocardial infarction.
Haplotype analysis of the matrix metalloproteinase 3 gene and myocardial infarction in a Chinese Han population. The Beijing atherosclerosis study.
High serum matrix metalloproteinase-9 level predict increased risk of in-hospital cardiac events in patients with type 2 diabetes and ST segment elevation myocardial infarction.
Imidapril and enalapril similarly inhibit plasma matrix metalloproteinase activities and attenuate left ventricular remodeling in patients with acute myocardial infarction.
Increased matrix metalloproteinase-8 and -9 activity in patients with infarct rupture after myocardial infarction.
Increased pericardial fluid level of matrix metalloproteinase-9 activity in patients with acute myocardial infarction: possible role in the development of cardiac rupture.
Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure.
Interleukin 18 and extracellular matrix metalloproteinase inducer cross-regulation: implications in acute myocardial infarction.
Intracoronary Delivery of Recombinant TIMP-3 Following Myocardial Infarction: Effects on Myocardial Remodeling and Function.
Intramyocardial injection of tannic acid attenuates postinfarction remodeling: a novel approach to stabilize the breaking extracellular matrix.
Macrophage overexpression of matrix metalloproteinase-9 in aged mice improves diastolic physiology and cardiac wound healing after myocardial infarction.
Matrix metalloproteinase -9 polymorphism and outcome after acute myocardial infarction.
Matrix Metalloproteinase 3 Gene Polymorphism and Its Level Predict Morbidity After Acute Myocardial Infarction.
Matrix metalloproteinase circulating levels, genetic polymorphisms, and susceptibility to acute myocardial infarction among patients with coronary artery disease.
Matrix metalloproteinase expression in cardiac myocytes following myocardial infarction in the rabbit.
Matrix metalloproteinase inhibition after myocardial infarction: a new approach to prevent heart failure?
Matrix metalloproteinase inhibition attenuates early left ventricular enlargement after experimental myocardial infarction in mice.
Matrix metalloproteinase inhibition modifies left ventricular remodeling after myocardial infarction in pigs.
Matrix Metalloproteinase Mediated Type I Collagen Degradation is an Independent Predictor of Increased Risk of Acute Myocardial Infarction in Postmenopausal Women.
Matrix metalloproteinase-28 deletion exacerbates cardiac dysfunction and rupture after myocardial infarction in mice by inhibiting M2 macrophage activation.
Matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 predict incident cardiovascular disease events and all-cause mortality in a population-based cohort.
Matrix metalloproteinase: investigation from gene to protein as effective factor in myocardial infarction.
Mesenchymal Stem Cells Promote Matrix Metalloproteinase Secretion By Cardiac Fibroblasts And Reduce Cardiac Ventricular Fibrosis After Myocardial Infarction.
Multiple-polymorphism associations of 7 matrix metalloproteinase and tissue inhibitor metalloproteinase genes with myocardial infarction and angiographic coronary artery disease.
Myocardial and interstitial matrix metalloproteinase activity after acute myocardial infarction in pigs.
Myocardial infarct expansion and matrix metalloproteinase inhibition.
Myocardial infarction induces early increased remote ADAM8 expression of rat hearts after cardiac arrest.
Myocardial Infarction Superimposed on Aging: MMP-9 Deletion Promotes M2 Macrophage Polarization.
Near-infrared fluorescent imaging of matrix metalloproteinase activity after myocardial infarction.
Nicorandil suppresses the increases in plasma level of matrix metalloproteinase activity and attenuates left ventricular remodeling in patients with acute myocardial infarction.
Perspectives on the value of biomarkers in acute cardiac care and implications for strategic management.
Plasma EMMPRIN levels in acute myocardial infarction and stable coronary artery disease.
Plasma tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-9: novel indicators of left ventricular remodelling and prognosis after acute myocardial infarction.
Pravastatin suppresses the increase in matrix metalloproteinase-2 levels after acute myocardial infarction.
Predictive utility of the changes in matrix metalloproteinase-2 in the early phase for left ventricular reverse remodeling after an acute myocardial infarction.
Protective effects on myocardial infarction model: delivery of schisandrin B using matrix metalloproteinase-sensitive peptide-modified, PEGylated lipid nanoparticles.
Putative targeting of matrix metalloproteinase-8 in atherosclerosis.
Relation of high concentrations of plasma carboxy-terminal telopeptide of collagen type I with outcome in acute myocardial infarction.
Relation of nocturnal melatonin levels to serum matrix metalloproteinase-9 concentrations in patients with myocardial infarction.
Relation of plasma matrix metalloproteinase-8 levels late after myocardial infarction with left ventricular volumes and ejection fraction.
Release of matrix metalloproteinases following alcohol septal ablation in hypertrophic obstructive cardiomyopathy.
Role of matrix metalloproteinases in coronary artery disease.
Salivary Matrix Metalloproteinase-8 and -9 and Myeloperoxidase in Relation to Coronary Heart and Periodontal Diseases: A Subgroup Report from the PAROKRANK Study (Periodontitis and Its Relation to Coronary Artery Disease).
Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction.
Selective targeting and timing of matrix metalloproteinase inhibition in post-myocardial infarction remodeling.
Serum matrix metalloproteinase-8 concentrations are associated with cardiovascular outcome in men.
Serum MMP-8: A Novel Indicator of Left Ventricular Remodeling and Cardiac Outcome in Patients after Acute Myocardial Infarction.
Serum tissue-degrading proteinases and incident cardiovascular disease events.
Sesamol Attenuates Isoproterenol-induced Acute Myocardial Infarction via Inhibition of Matrix Metalloproteinase-2 and -9 Expression in Rats.
Significance of matrix metalloproteinase-9 in cardiac dysfunction during the very acute phase after myocardial infarction in hamsters.
Specific temporal profile of matrix metalloproteinase release occurs in patients after myocardial infarction: relation to left ventricular remodeling.
Systemic versus coronary levels of inflammation in acute coronary syndromes.
Temporal changes in matrix metalloproteinase expression and inflammatory response associated with cardiac rupture after myocardial infarction in mice.
The compendium of matrix metalloproteinase expression in the left ventricle of mice following myocardial infarction.
The Matrix Metalloproteinase 2-1575 gene Polymorphism is Associated with the Risk of Developing Myocardial Infarction in Mexican Patients.
Time-dependent changes in the plasma concentration of matrix metalloproteinase 9 after acute myocardial infarction.
Translating Koch's postulates to identify matrix metalloproteinase roles in postmyocardial infarction remodeling: cardiac metalloproteinase actions (CarMA) postulates.
Usefulness of plasma tissue inhibitors of metalloproteinases as markers of prognosis after acute myocardial infarction.
[Comparison of doxycycline, losartan, and their combination on the expression of matrix metalloproteinase, tissue inhibitor of matrix metalloproteinase, and collagen remodeling in the noninfarcted myocardium after acute myocardial infarction in rats]
[Comparison of right atrial matrix metalloproteinase expression between patients with unstable angina and myocardial infarction]
[Effects of doxycycline on the expression of matrix metalloproteinase and tissue inhibitor of MMP in myocardium after acute myocardial infarction: an animal experiment with rats]
[Implications of serum matrix metalloproteinase-8 elevation in patients with acute coronary syndrome]
[In vivo interleukin-10 gene transfer down-regulates myocardial matrix metalloproteinase and myocardial collagen expressions in rats with acute myocardial infarction]
[Measurement peripheral blood index related to inflammation and ox-LDL, ox-LDLAb in patients with coronary heart disease and its clinical significance]
Myocardial Ischemia
Circulating biomarkers of extracellular matrix remodeling and risk of atherosclerotic events.
Disrupting the Extracellular Matrix Metalloproteinase Inducer-Cyclophilin A Interaction Reduces Infarct Size and Preserves Systolic Function After Myocardial Ischemia and Reperfusion.
Tumor necrosis factor-alpha G(-308)A promoter polymorphism, matrix metalloproteinase (MMP)-3 5A/6A gene variation, MMP-9 C(-1562)T promoter polymorphism and risk and extent of ischemic heart disease.
[Polymorphisms in Genes of Cytokines and Matrix Metalloproteinases Associated With Ischemic Heart Disease in Patients With Type 2 Diabetes].
Myocarditis
Adiponectin attenuates profibrotic extracellular matrix remodeling following cardiac injury by up-regulating matrix metalloproteinase 9 expression in mice.
Carvedilol improves left ventricular function in murine coxsackievirus-induced acute myocarditis association with reduced myocardial interleukin-1beta and MMP-8 expression and a modulated immune response.
Collagen degradation in a murine myocarditis model: relevance of matrix metalloproteinase in association with inflammatory induction.
Dynamic changes in myocardial matrix metalloproteinase activity in mice with viral myocarditis.
Early treatment with clarithromycin attenuates rat autoimmune myocarditis via inhibition of matrix metalloproteinase activity.
Matrix metalloproteinase (MMP)-9, but not MMP-2, is involved in the development and progression of C protein-induced myocarditis and subsequent dilated cardiomyopathy.
Matrix metalloproteinases in the pathogenesis of viral heart disease.
Targeting matrix metalloproteinase activity and expression for the treatment of viral myocarditis.
Myoma
Extracellular matrix metalloproteinase expression in endometrial tissue after arterial embolization of myomas.
Matrix metalloproteinase activity correlates with uterine myoma volume reduction after ulipristal acetate treatment.
Myopia
Anti-Inflammatory Effects of Resveratrol on Human Retinal Pigment Cells and a Myopia Animal Model.
Changes of TGF-?2, MMP-2, and TIMP-2 levels in the vitreous of patients with high myopia.
Gelatinase A and TIMP-2 expression in the fibrous sclera of myopic and recovering chick eyes.
Inhibition of matrix metalloproteinase activity in the chick sclera and its effect on myopia development.
Myositis
Matrix Metalloproteinase Responsive Delivery of Myostatin Inhibitors.
Specific matrix metalloproteinase expression in focal myositis: an immunopathological study.
Myxoma
The expression of apoptotic proteins and matrix metalloproteinases in odontogenic myxomas.
Nasal Polyps
Double-stranded RNA poly(I:C) enhances matrix metalloproteinase mRNA expression in human nasal polyp epithelial cells.
Expression of extracellular matrix metalloproteinase inducer in nasal polyps.
Involvement of the extracellular matrix proteins periostin and tenascin C in nasal polyp remodeling by regulating the expression of MMPs.
Matrix metalloproteinase-9 promoter gene polymorphism (-1562C>T) in nasal polyposis.
Rhinovirus upregulates matrix metalloproteinase-2, matrix metalloproteinase-9, and vascular endothelial growth factor expression in nasal polyp fibroblasts.
Sirtuin-1 Controls Poly (I:C)-Dependent Matrix Metalloproteinase 9 Activation in Primary Human Nasal Epithelial Cells.
Staphylococcus aureus increases cytokine and matrix metalloproteinase expression in nasal mucosae of patients with chronic rhinosinusitis and nasal polyps.
Suppression of matrix metalloproteinase production from nasal fibroblasts by fluticasone propionate in vitro.
Suppression of matrix metalloproteinase production from nasal fibroblasts by macrolide antibiotics in vitro.
[Effects of double-stranded RNA poly(I:C) on matrix metalloproteinase mRNA expression in human nasal polyp epithelial cells]
Nasopharyngeal Carcinoma
Correlation between expression of extracellular matrix metalloproteinase inducer and matrix metalloproteinase-2 and cervical lymph node metastasis of nasopharyngeal carcinoma.
Expression of bcl-2 correlates with poor prognosis and modulates migration of nasopharyngeal carcinoma cells.
Functional polymorphisms of matrix metalloproteinase-9 and survival in patients with locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy.
Matrix metalloproteinase 13-containing exosomes promote nasopharyngeal carcinoma metastasis.
Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells.
Overexpression of Asparagine Synthetase and Matrix Metalloproteinase 19 Confers Cisplatin Sensitivity in Nasopharyngeal Carcinoma Cells.
[Study of the relation between MMP2, MMP9 and nasopharyngeal carcinoma]
Neonatal Sepsis
The involvement of human amnion in histologic chorioamnionitis is an indicator that a fetal and an intra-amniotic inflammatory response is more likely and severe: clinical implications.
Neoplasm Metastasis
"Locked" cancer cells are more sensitive to chemotherapy.
(-)-Epigallocatechin-3-gallate promotes pro-matrix metalloproteinase-7 production via activation of the JNK1/2 pathway in HT-29 human colorectal cancer cells.
-(-)Epigallocatechin-3-gallate downregulates EGFR, MMP-2, MMP-9 EMMPRIN and inhibits the invasion of MCF-7 tamoxifen resistant cells.
1?Palmitoyl?2?linoleoyl?3?acetyl?rac?glycerol ameliorates EGF?induced MMP?9 expression by promoting receptor desensitization in MDA?MB?231 cells.
A dose-finding and pharmacokinetic study of the matrix metalloproteinase inhibitor MMI270 (previously termed CGS27023A) with 5-FU and folinic acid.
A high throughput fluorogenic substrate for interstitial collagenase (MMP-1) and gelatinase (MMP-9).
A high throughput fluorogenic substrate for stromelysin (MMP-3).
A matrix metalloproteinase inhibitor, batimastat, retards the development of osteolytic bone metastases by MDA-MB-231 human breast cancer cells in Balb C nu/nu mice.
A Model for the Solution Structure of Human Fe(II)-Bound Acireductone Dioxygenase and Interactions with the Regulatory Domain of Matrix Metalloproteinase I (MMP-I).
A new matrix metalloproteinase-9 inhibitor 3,4-dihydroxycinnamic acid (caffeic acid) from methanol extract of Euonymus alatus: isolation and structure determination.
A novel functional site of extracellular matrix metalloproteinase inducer (EMMPRIN) that limits the migration of human uterine cervical carcinoma cells.
A novel interaction between calcium-modulating cyclophilin ligand and Basigin regulates calcium signaling and matrix metalloproteinase activities in human melanoma cells.
A novel matrix metalloproteinase inhibitor, FYK-1388 suppresses tumor growth, metastasis and angiogenesis by human fibrosarcoma cell line.
A novel role of interleukin-13 receptor alpha2 in pancreatic cancer invasion and metastasis.
A novel small-molecule compound targeting CD147 inhibits the motility and invasion of hepatocellular carcinoma cells.
A phase II trial of marimastat in advanced pancreatic cancer.
A prostate secretory protein94-derived synthetic peptide PCK3145 inhibits VEGF signalling in endothelial cells: Implication in tumor angiogenesis.
A PSP94-derived peptide PCK3145 inhibits MMP-9 secretion and triggers CD44 cell surface shedding: implication in tumor metastasis.
A Randomized Phase II Trial of the Matrix Metalloproteinase Inhibitor BMS-275291 in Hormone-Refractory Prostate Cancer Patients with Bone Metastases.
A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter is associated with conventional renal cell carcinoma.
Aberrant Pim-3 expression is involved in gastric adenoma-adenocarcinoma sequence and cancer progression.
Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice.
Activating transcription factor 4 promotes esophageal squamous cell carcinoma invasion and metastasis in mice and is associated with poor prognosis in human patients.
Adhesive defect in extracellular matrix tenascin-X-null fibroblasts: a possible mechanism of tumor invasion.
Alendronate regulates cell invasion and MMP-2 secretion in human osteosarcoma cell lines.
alpha-Lipoic acid reduces matrix metalloproteinase activity in MDA-MB-231 human breast cancer cells.
Alterations of the tissue inhibitor of metalloproteinase-3 (TIMP3) gene in pancreatic adenocarcinomas.
Altered matrix metalloproteinase expression associated with oncogene-mediated cellular transformation and metastasis formation.
Altered metastatic behavior of human breast cancer cells after experimental manipulation of matrix metalloproteinase 8 gene expression.
An immunohistochemical study of TIMP-3 expression in oesophageal squamous cell carcinoma.
An in vivo model for screening peptidomimetic inhibitors of gelatinase A.
An Unusually Stable G-Quadruplex within the 5'-UTR of the MT3 Matrix Metalloproteinase mRNA Represses Translation in Eukaryotic Cells.
Anti-vascular endothelial growth factor receptor 2 antibody reduces tumorigenicity and metastasis in orthotopic prostate cancer xenografts via induction of endothelial cell apoptosis and reduction of endothelial cell matrix metalloproteinase type 9 production.
Anticancer effects of four varieties of muscadine grape.
Antimetastasis Effect of Anthraquinones from Marine Fungus, Microsporum sp.
Assay of matrix metalloproteases types 8 and 9 by ELISA in human breast cancer.
Assessment of Cannabinoids Agonist and Antagonist in Invasion Potential of K562 Cancer Cells
Association between expression of MMP-7 and MMP-9 and pelvic lymph node and para-aortic lymph node metastasis in early cervical cancer.
Association between immunohistochemical expression of matrix metalloproteinases and metastasis in oral squamous cell carcinoma: Systematic review and meta-analysis.
Association between ratio of matrix metalloproteinase-1 to tissue inhibitor of metalloproteinase-1 and local recurrence, metastasis, and survival in human chondrosarcoma.
Association of CD44 V3-containing isoforms with tumor cell growth, migration, matrix metalloproteinase expression, and lymph node metastasis in head and neck cancer.
Association of functional polymorphisms of matrix metalloproteinase (MMP)-1 and MMP-3 genes with colorectal cancer.
Association of matrix metalloproteinase (MMP)-2 and -9 expression with extra-gastrointestinal stromal tumor metastasis.
Association of Matrix Metalloproteinase-8 Gene Variation with Breast Cancer Prognosis.
Augment the efficacy of eradicating metastatic lesions and tumor proliferation in breast cancer by honokiol-loaded pH-sensitive targeted lipid nanoparticles.
Augmented anti-metastatic efficacy of a selective matrix metalloproteinase inhibitor, MMI-166, in combination with CPT-11.
Baicalein Attenuates Oxidative Stress-Induced Expression of Matrix Metalloproteinase-1 by Regulating the ERK/JNK/AP-1 Pathway in Human Keratinocytes.
Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding.
Benefit of adjuvant interferon alfa-2b (IFN-?) therapy in melanoma patients with high serum MMP-8 levels.
Blockade of Asparagine Endopeptidase Inhibits Cancer Metastasis.
Bone marrow-derived cells and epithelial tumours: more than just an inflammatory relationship.
Caffeoyl pyrrolidine derivative LY52 inhibits tumor invasion and metastasis via suppression of matrix metalloproteinase activity.
Capsaicin and sorafenib combination treatment exerts synergistic anti?hepatocellular carcinoma activity by suppressing EGFR and PI3K/Akt/mTOR signaling.
Carbamoylphosphonate matrix metalloproteinase inhibitors 3: in vivo evaluation of cyclopentylcarbamoylphosphonic acid in experimental metastasis and angiogenesis.
Cathepsin G enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-kappaB ligand.
Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion.
Caveolin-1 modulates the ability of Ewing's sarcoma to metastasize.
Caveolin-1 regulating the invasion and expression of matrix metalloproteinase (MMPs) in pancreatic carcinoma cells.
CD147 deficiency blocks IL-8 secretion and inhibits lung cancer-induced osteoclastogenesis.
CD147 depletion down-regulates matrix metalloproteinase-11, vascular endothelial growth factor-A expression and the lymphatic metastasis potential of murine hepatocarcinoma Hca-F cells.
CD97 Promotes Tumor Aggressiveness Through the Traditional G Protein-Coupled Receptor-Mediated Signaling in Hepatocellular Carcinoma.
Cell Specific Matrix Metalloproteinase-1 Regulates Lung Metastasis Synergistically with Smoke Exposure.
Cell surface association of matrix metalloproteinase-9 (gelatinase B).
Cell-based identification of natural substrates and cleavage sites for extracellular proteases by SILAC proteomics.
Cellular localization of EMMPRIN predicts prognosis of patients with operable lung adenocarcinoma independent from MMP-2 and MMP-9.
Circulating MMP2 and MMP9 in breast cancer -- potential role in classification of patients into low risk, high risk, benign disease and breast cancer categories.
Clinical implications of matrix metalloproteinase-1, -3, -7, -9, -12, and plasminogen activator inhibitor-1 gene polymorphisms in colorectal cancer.
Clinicopathological features and overexpression of matrix metalloproteinases in intramucosal gastric carcinoma with lymph node metastasis.
Combined evaluation of matrix metalloproteinases and their inhibitors has better clinical utility in oral cancer.
Comparative Profiling of Metastatic 4T1- vs. Non-metastatic Py230-Based Mammary Tumors in an Intraductal Model for Triple-Negative Breast Cancer.
Comparison of matrix metalloproteinase expression between primary tumors with or without liver metastasis in pancreatic and colorectal carcinomas.
Computational insights into the identification of a potent matrix metalloproteinase inhibitor from Indigofera aspalathoides to control cancer metastasis.
Contributions of lung tissue extracts to invasion and migration of human hepatocellular carcinoma cells with various metastatic potentials.
Contributions of Thyroid Hormone to Cancer Metastasis.
Control of lymphatic and hematogenous metastasis of a rat mammary carcinoma by the matrix metalloproteinase inhibitor batimastat (BB-94).
Controlling tumor angiogenesis and metastasis of C26 murine colon adenocarcinoma by a new matrix metalloproteinase inhibitor, KB-R7785, in two tumor models.
Correlation and prognostic significance of MMP-2 and TFPI-2 differential expression in pancreatic carcinoma.
Correlation between expression of extracellular matrix metalloproteinase inducer and matrix metalloproteinase-2 and cervical lymph node metastasis of nasopharyngeal carcinoma.
Correlation of matrix metalloproteinase-2, -9, tissue inhibitor-1 of matrix metalloproteinase and CD44 variant 6 in head and neck cancer metastasis.
Correlation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinase expression in ileal carcinoids, lymph nodes and liver metastasis with prognosis and survival.
Correlation of metastasis related gene expression and relapse-free survival in patients with locally advanced bladder cancer treated with cystectomy and chemotherapy.
Critical role and its underlying molecular events of the plasminogen receptor, S100A10 in malignant tumor and non-tumor diseases.
Critical role for matrix metalloproteinase-9 in platelet-activating factor-induced experimental tumor metastasis.
Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene.
Crosstalk between TGF-? signaling and miRNAs in breast cancer metastasis.
CRP2, a new invadopodia actin bundling factor critically promotes breast cancer cell invasion and metastasis.
Current status and future prospects of transforming growth factor-? as a potential prognostic and therapeutic target in the treatment of breast cancer.
Decrease of MLK4 prevents hepatocellular carcinoma (HCC) through reducing metastasis and inducing apoptosis regulated by ROS/MAPKs signaling.
Des-?-carboxy prothrombin (DCP) as a potential autologous growth factor for the development of hepatocellular carcinoma.
Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3).
Detection of Cancer-Specific Proteases Using Magnetic Relaxation of Peptide-Conjugated Nanoparticles in Biological Environment.
Development of a Novel PET Tracer [18F]AlF-NOTA-C6 Targeting MMP2 for Tumor Imaging.
Development of putrescine anchored nano-crystalsomes bearing doxorubicin and oleanolic acid: deciphering their role in inhibiting metastatic breast cancer.
Dexamethasone Reduces Cell Adhesion and Migration of T47D Breast Cancer Cell Line.
DHA blocks TPA-induced cell invasion by inhibiting MMP-9 expression via suppression of the PPAR-?/NF-?B pathway in MCF-7 cells.
Dieckol from Ecklonia cava Regulates Invasion of Human Fibrosarcoma Cells and Modulates MMP-2 and MMP-9 Expression via NF-?B Pathway.
Different expression patterns of MMP-2 and MMP-9 in breast cancer.
Different Role of Caveolin-1 Gene in the Progression of Gynecological Tumors.
Differential regulation of matrix metalloproteinases in human cancer cells by exogenous factors.
Differing effects of endogenous and synthetic inhibitors of metalloproteinases on intestinal tumorigenesis.
Diosmetin inhibits the metastasis of hepatocellular carcinoma cells by downregulating the expression levels of MMP?2 and MMP?9.
Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells.
DNMT1 recruited by EZH2-mediated silencing of miR-484 contributes to the malignancy of cervical cancer cells through MMP14 and HNF1A.
Down-regulation of matrix-invasive potential of human liver cancer cells by type I interferon and a histone deacetylase inhibitor sodium butyrate.
Downregulation of Extracellular Matrix Metalloproteinase Inducer by scFv-M6-1B9 Intrabody Suppresses Cervical Cancer Invasion Through Inhibition of Urokinase-Type Plasminogen Activator.
Downregulation of HuR Inhibits the Progression of Esophageal Cancer through Interleukin-18.
Downregulation of LGI1 promotes tumor metastasis in esophageal squamous cell carcinoma.
Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer.
Downregulation of the Novel Tumor Suppressor DIRAS1 Predicts Poor Prognosis in Esophageal Squamous Cell Carcinoma.
Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals.
Effect of a matrix metalloproteinase inhibitor (ONO-4817) on lung metastasis of murine renal cell carcinoma.
Effect of a nutrient mixture on matrix metalloproteinase-9 dimers in various human cancer cell lines.
Effect of CO2 pneumoperitoneum on the proliferation of human ovarian cancer cell line SKOV-3 and the expression of NM23-H1 and MMP-2.
Effect of combination therapy with matrix metalloproteinase inhibitor MMI-166 and mitomycin C on the growth and liver metastasis of human colon cancer.
Effect of matrix metalloproteinase inhibition on pancreatic cancer invasion and metastasis: an additive strategy for cancer control.
Effect of matrix metalloproteinase inhibitor batimastat on breast cancer regrowth and metastasis in athymic mice.
Effect of matrix metalloproteinase inhibitors on tumor growth and spontaneous metastasis.
Effects of HAb18G/CD147 Knockout on Hepatocellular Carcinoma Cells In Vitro Using a Novel Zinc-Finger Nuclease-Targeted Gene Knockout Approach.
Effects of matrix metalloproteinase inhibitor BB-94 on liver cancer growth and metastasis in a patient-like orthotopic model LCI-D20.
Elevated level of circulating matrix metalloproteinase-9 in patients with lung cancer.
Elevated levels of circulating plasma matrix metalloproteinase 9 in non-small cell lung cancer patients.
Elevated matrix metalloproteinase 7 expression promotes the proliferation, motility and metastasis of tongue squamous cell carcinoma.
Elevated sod2 activity augments matrix metalloproteinase expression: evidence for the involvement of endogenous hydrogen peroxide in regulating metastasis.
EMMPRIN (basigin/CD147) expression is not correlated with MMP activity during adult mouse mammary gland development.
EMMPRIN (CD147) expression and differentiation of papillary thyroid carcinoma: implications for immunocytochemistry in FNA cytology.
EMMPRIN expression as a prognostic factor in radiotherapy of cervical cancer.
EMMPRIN is associated with S100A4 and predicts patient outcome in colorectal cancer.
EMMPRIN reduction via scFv-M6-1B9 intrabody affects ?3?1-integrin and MCT1 functions and results in suppression of progressive phenotype in the colorectal cancer cell line Caco-2.
Epigallocatechin-3-gallate inhibits photocarcinogenesis through inhibition of angiogenic factors and activation of CD8+ T cells in tumors.
Epigallocatechin-3-gallate inhibits the invasion of human oral cancer cells and decreases the productions of matrix metalloproteinases and urokinase-plasminogen activator.
Epithelial to mesenchymal transition inducing transcription factors and metastatic cancer.
Ets-related protein E1A-F can activate three different matrix metalloproteinase gene promoters.
ETV5 as a regulator of matrix metalloproteinase 2 in human chondrosarcoma.
Evaluation of MMP-9 and MMP-2 and their suppressor TIMP-1 and TIMP-2 in adenocarcinoma of esophagogastric junction.
Evidence for a role of GPRC6A in prostate cancer metastasis based on case-control and in vitro analyses.
Expression and Clinical Significance of CD147 in Genitourinary Carcinomas.
Expression and clinical significance of extracellular matrix metalloproteinase inducer, EMMPRIN/CD147, in human osteosarcoma.
Expression and clinical significance of matrix metalloproteinase (MMP)-26 protein in non-small cell lung cancer.
Expression and localization of 72 kDa type IV collagenase (MMP-2) in human malignant gliomas in vivo.
Expression of CD147 is associated with prostate cancer progression.
Expression of extracellular matrix metalloproteinase inducer and fascin in urinary bladder cancer: Correlation with clinicopathological characteristics.
Expression of FLJ10540 is correlated with aggressiveness of oral cavity squamous cell carcinoma by stimulating cell migration and invasion through increased FOXM1 and MMP-2 activity.
Expression of matrix metalloproteinase 8 (MMP-8) and tyrosinase-related protein-1 (TYRP-1) correlates with the absence of metastasis in an isogenic human breast cancer model.
Expression of matrix metalloproteinase matrilysin (MMP-7) was induced by activated Ki-ras via AP-1 activation in SW1417 colon cancer cells.
Expression of matrix metalloproteinase, tissue inhibitors of metalloproteinase and adhesion molecules in silicotic mice with lung tumor metastasis.
Expression of matrix metalloproteinases-2, -8, -13, -26, and tissue inhibitors of metalloproteinase-1 in human osteosarcoma.
Expression of MMP-13 is associated with invasion and metastasis of papillary thyroid carcinoma.
Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response.
Expression of the reversion-inducing cysteine-rich protein with Kazal motifs and matrix metalloproteinase-14 in neuroblastoma and the role in tumour metastasis.
Expressions of CD147, MMP-2 and MMP-9 in Laryngeal Carcinoma and its Correlation with Poor Prognosis.
Expressions of matrix metalloproteinases in early-stage oral squamous cell carcinoma as predictive indicators for tumor metastases and prognosis.
Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim.
Extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinases (MMPs) as regulators of tumor-host interaction in a spontaneous metastasis model in rats.
Extracellular matrix metalloproteinase inducer expression has an impact on survival in human bladder cancer.
Failure of matrix metalloproteinase-9 dimer induction by phorbol 12-myristate 13-acetate in normal human cell lines.
Fe3O4-solamargine induces apoptosis and inhibits metastasis of pancreatic cancer cells.
Fibrinogen in the glioblastoma microenvironment contributes to the invasiveness of brain tumor-initiating cells.
Full-length L1CAM and not its ?2?27 splice variant promotes metastasis through induction of gelatinase expression.
Functional proteomics study reveals that N-Acetylglucosaminyltransferase V reinforces the invasive/metastatic potential of colon cancer through aberrant glycosylation on tissue inhibitor of metalloproteinase-1.
Functional significance of secreted Frizzled-related protein 1 in metastatic renal cell carcinomas.
Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: imprisoning instead of poisoning cancer cells.
Galectin-1-mediated tumor invasion and metastasis, up-regulated matrix metalloproteinase expression, and reorganized actin cytoskeletons.
Gamma-aminobutyric acid as a promoting factor of cancer metastasis; induction of matrix metalloproteinase production is potentially its underlying mechanism.
Gefitinib decreases the synthesis of matrix metalloproteinase and the adhesion to extracellular matrix proteins of colon cancer cells.
Gelatinases and their inhibitors in tumor metastasis: from biological research to medical applications.
Gene expression profile of ovarian serous papillary carcinomas: identification of metastasis-associated genes.
Giant cell tumor of bone: an immunohistochemical comparative study.
Group IB secretory phospholipase A2 promotes matrix metalloproteinase-2-mediated cell migration via the phosphatidylinositol 3-kinase and Akt pathway.
Ham-Wasserman lecture: role of the plasminogen system in fibrin-homeostasis and tissue remodeling.
Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential.
Hepatitis C virus core protein promotes the migration and invasion of hepatocyte via activating transcription of extracellular matrix metalloproteinase inducer.
Hepatocyte growth factor and HER2/neu downregulate expression of apoptosis-inducing factor in non-small cell lung cancer.
HER-2/neu Represses the Metastasis Suppressor RECK via ERK and Sp Transcription Factors to Promote Cell Invasion.
Heteronemin Induces Anti-Proliferation in Cholangiocarcinoma Cells via Inhibiting TGF-? Pathway.
High Expression of MMP-9 in Primary Tumors and High Preoperative MPO in Serum Predict Improved Prognosis in Colorectal Cancer with Operable Liver Metastases.
High extracellular matrix metalloproteinase inducer/CD147 expression is strongly and independently associated with poor prognosis in colorectal cancer.
High incidence of EMMPRIN expression in human tumors.
High Mobility Group Box-1 promotes hepatocellular carcinoma progression through miR-21-mediated matrix metalloproteinase activity.
High tissue MMP14 expression predicts worse survival in gastric cancer, particularly with a low PROX1.
High-serum MMP-8 levels are associated with decreased survival and systemic inflammation in colorectal cancer.
Histologic features of venous invasion, expression of vascular endothelial growth factor and matrix metalloproteinase-2 and matrix metalloproteinase-9, and the relation with liver metastasis in pancreatic cancer.
Histone Deacetylase (HDAC) 10 Suppresses Cervical Cancer Metastasis through Inhibition of Matrix Metalloproteinase (MMP) 2 and 9 Expression.
Honokiol inhibits non-small cell lung cancer cell migration by targeting PGE?-mediated activation of ?-catenin signaling.
Human mammary fibroblasts stimulate invasion of breast cancer cells in a three-dimensional culture and increase stroma development in mouse xenografts.
Hydrolysis of triple-helical collagen peptide models by matrix metalloproteinases.
Hydroxamate-type matrix metalloproteinase inhibitor batimastat promotes liver metastasis.
Hypermethylation of miR-338-3p and Impact of its Suppression on Cell Metastasis Through N-Cadherin Accumulation at the Cell -Cell Junction and Degradation of MMP in Gastric Cancer.
Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues.
Identification of highly selective MMP-14 inhibitory Fabs by deep sequencing.
Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma.
Identification of metastasis candidate proteins among HCC cell lines by comparative proteome and biological function analysis of S100A4 in metastasis in vitro.
Immunohistochemical expression of matrix metalloproteinase-2 and -9 in melanocytic nevi is altered by ultraviolet B.
Immunohistochemical levels of matrix metalloproteinase-2 and CD44 variant 6 protein in the diagnosis and lateral cervical lymph node metastasis of papillary thyroid carcinoma.
Immunohistochemical study of MT-MMP tissue status in gastric carcinoma and correlation with survival analyzed by univariate and multivariate analysis.
Immunolocalization of MMP9 and MMP2 in osteolytic metastasis originating from MDA-MB-231 human breast cancer cells.
Immunological characterization of cell-surface and soluble forms of membrane type 1 matrix metalloproteinase in human breast cancer cells and in fibroblasts.
Impact of Matrix Metalloproteinase-11 Gene Polymorphisms on Biochemical Recurrence and Clinicopathological Characteristics of Prostate Cancer.
In Situ Protease Secretion Visualization and Metastatic Lymph Nodes Imaging via a Cell Membrane-Anchored Upconversion Nanoprobe.
In vitro inhibition of matrix metalloproteinases, invasion and growth of Fanconi anemia human FANCA and FANCC lymphoblasts by nutrient mixture.
In vitro modulation of MMP-2 and MMP-9 in adult human sarcoma cell lines by cytokines, inducers and inhibitors.
In vitro modulation of MMP-2 and MMP-9 in pediatric human sarcoma cell lines by cytokines, inducers and inhibitors.
Inactivation of the tissue inhibitor of metalloproteinases-2 gene by promoter hypermethylation in lymphoid malignancies.
Inclusion complex from cyclodextrin-grafted hyaluronic acid and pseudo protein as biodegradable nano-delivery vehicle for gambogic acid.
Increased metastases are associated with inflammation and matrix metalloproteinase-9 activity at incision sites in a murine model of peritoneal dissemination of colorectal cancer.
Induction of RECK by nonsteroidal anti-inflammatory drugs in lung cancer cells.
Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3.
Influence of HPV16 E2 and its localisation on the expression of matrix metalloproteinase-9.
Inhibition of AGS human gastric cancer cell invasion and proliferation by Capsosiphon fulvescens glycoprotein.
Inhibition of angiogenesis and metastasis in two murine models by the matrix metalloproteinase inhibitor, BMS-275291.
Inhibition of breast cancer cell extracellular matrix degradative activity by chemically modified tetracyclines.
Inhibition of Breast Cancer Metastasis by Presurgical Treatment with an Oral Matrix Metalloproteinase Inhibitor: A Preclinical Proof-of-Principle Study.
Inhibition of CD147 Expression Reduces Tumor Cell Invasion in Human Prostate Cancer Cell Line via RNA Interference.
Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to cisplatin in laryngeal carcinoma Hep2 cells.
Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to paclitaxel in HO-8910pm cells.
Inhibition of gelatinase A (MMP-2) by batimastat and captopril reduces tumor growth and lung metastases in mice bearing Lewis lung carcinoma.
Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism-based selective gelatinase inhibitor.
Inhibition of invasion and lymph node metastasis of gastrointestinal cancer cells by R-94138, a matrix metalloproteinase inhibitor.
Inhibition of invasion and MMPs by a nutrient mixture in human cancer cell lines: a correlation study.
Inhibition of lymphangiogenesis-related properties of murine lymphatic endothelial cells and lymph node metastasis of lung cancer by the matrix metalloproteinase inhibitor MMI270.
Inhibition of matrix metalloproteinase expression by menatetrenone, a vitamin K2 analogue.
Inhibition of matrix metalloproteinase-14 in osteosarcoma cells by clodronate.
Inhibition of MMP-9 transcription and suppression of tumor metastasis by pyrrole-imidazole polyamide.
Inhibition of organ invasion by the matrix metalloproteinase inhibitor batimastat (BB-94) in two human colon carcinoma metastasis models.
Inhibition of spontaneous rat osteosarcoma lung metastasis by 3S-[4-(N-hydroxyamino)-2R-isobutylsuccinyl]amino-1-methoxy-3,4-dihydroc arbostyril, a novel matrix metalloproteinase inhibitor.
Inhibitive effect of celecoxib on the adhesion and invasion of human tongue squamous carcinoma cells to extracellular matrix via down regulation of MMP-2 expression.
Inhibitory effect of methanol extract of Euonymus alatus on matrix metalloproteinase-9.
Inhibitory effect of shRNA targeting GPR48 on invasion and metastasis of human cervical carcinoma cell line HeLa.
Inhibitory effects of a benz[f]indole-4,9-dione analog on cancer cell metastasis mediated by the down-regulation of matrix metalloproteinase expression in human HT1080 fibrosarcoma cells.
Inhibitory effects of caffeic acid phenethyl ester on cancer cell metastasis mediated by the down-regulation of matrix metalloproteinase expression in human HT1080 fibrosarcoma cells.
Inhibitory effects of low intensity pulsed ultrasound on osteoclastogenesis induced in vitro by breast cancer cells.
Inhibitory effects of tanshinone II-A on invasion and metastasis of human colon carcinoma cells.
Insight towards the conserved water mediated recognition of catalytic and structural Zn(+2) ions in human Matrix Metalloproteinase-8 enzyme: A study by MD-simulation methods.
Intelligently targeted drug delivery and enhanced antitumor effect by gelatinase-responsive nanoparticles.
Interleukin 8 expression regulates tumorigenicity and metastasis in human bladder cancer.
Interleukin-1 alpha promotes tumor growth and cachexia in MCF-7 xenograft model of breast cancer.
Interleukin-32 stimulates osteosarcoma cell invasion and motility via AKT pathway-mediated MMP-13 expression.
Intracellular Acidosis Promotes Mitochondrial Apoptosis Pathway: Role of EMMPRIN Down-regulation via Specific Single-chain Fv Intrabody.
Intracellular matrix metalloproteinase-2 (MMP-2) regulates human platelet activation via hydrolysis of talin.
Involvement of histone deacetylation in ras-induced down-regulation of the metastasis suppressor RECK.
Involvement of inactive GSK3beta overexpression in tumorigenesis and progression of gastric carcinomas.
Isoliquiritin Apioside Suppresses in vitro Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells.
JNP3, a new compound, suppresses PMA-induced tumor cell invasion via NF-?B down regulation in MCF-7 breast cancer cells.
KI-67 AND hTERT expression can aid in the distinction between malignant and benign pheochromocytoma and paraganglioma.
Knockdown of Matrix Metallopeptidase 9 Inhibits Metastasis of Oral Squamous Cell Carcinoma Cells in a Zebrafish Xenograft Model.
Lack of matrix metalloproteinase (MMP)-1 and -3 expression in Ewing sarcoma may be due to loss of accessibility of the MMP regulatory element to the specific fusion protein in vivo.
Lentiviral-mediated miRNA against osteopontin suppresses tumor growth and metastasis of human hepatocellular carcinoma.
Lentivirus mediated RNA interference of EMMPRIN (CD147) gene inhibits the proliferation, matrigel invasion and tumor formation of breast cancer cells.
Long non-coding RNA GASL1 restrains gastric carcinoma cell proliferation and metastasis by sponging microRNA-106a.
Long non-coding RNA SNHG5 affects the invasion and apoptosis of renal cell carcinoma by regulating the miR-363-3p-Twist1 interaction.
Low expression of reversion-inducing cysteine-rich protein with Kazal motifs (RECK) indicates a shorter survival after resection in patients with adenocarcinoma of the lung.
Luteolin-7-O-Glucoside Inhibits Oral Cancer Cell Migration and Invasion by Regulating Matrix Metalloproteinase-2 Expression and Extracellular Signal-Regulated Kinase Pathway.
Lysophosphatidic acid augments human hepatocellular carcinoma cell invasion through LPA1 receptor and MMP-9 expression.
Macrophage ABHD5 suppresses NF-?B-dependent matrix metalloproteinase expression and cancer metastasis.
Matrilysin in early stage intestinal tumorigenesis.
Matrilysin-specific antisense oligonucleotide inhibits liver metastasis of human colon cancer cells in a nude mouse model.
Matrilysins may not predict the metastatic potential in squamous cell carcinoma of the tongue.
Matrix metalloproteinase (MMP)-9 in cancer-associated fibroblasts (CAFs) is suppressed by omega-3 polyunsaturated fatty acids in vitro and in vivo.
Matrix metalloproteinase 12 is induced by heterogeneous nuclear ribonucleoprotein K and promotes migration and invasion in nasopharyngeal carcinoma.
Matrix metalloproteinase 13-containing exosomes promote nasopharyngeal carcinoma metastasis.
Matrix metalloproteinase 9 expression and prognosis in colorectal cancer: a meta-analysis.
Matrix metalloproteinase 9 is induced by the Epstein-Barr virus BZLF1 transactivator.
Matrix metalloproteinase activity and osteoclasts in experimental prostate cancer bone metastasis tissue.
Matrix metalloproteinase activity, bone matrix turnover, and tumor cell proliferation in prostate cancer bone metastasis.
Matrix metalloproteinase contribution in management of cancer proliferation, metastasis and drug targeting.
Matrix metalloproteinase expression in malignant melanomas: tumor-extracellular matrix interactions in invasion and metastasis.
Matrix metalloproteinase inhibitor MMI-166 inhibits lymphogenous metastasis in an orthotopically implanted model of lung cancer.
Matrix metalloproteinase inhibitor RO 28-2653 decreases liver metastasis by reduction of MMP-2 and MMP-9 concentration in BOP-induced ductal pancreatic cancer in Syrian Hamsters: inhibition of matrix metalloproteinases in pancreatic cancer.
Matrix metalloproteinase inhibitor, MMI270 (CGS27023A) inhibited hematogenic metastasis of B16 melanoma cells in both experimental and spontaneous metastasis models.
Matrix metalloproteinase inhibitors (MMPIs) from marine natural products: the current situation and future prospects.
Matrix metalloproteinase-13 is a target gene of high-mobility group box-containing protein 1 in modulating oral cancer cell invasion.
Matrix metalloproteinase-2 (72 kD type IV collagenase) expression occurs in the early stage of human melanocytic tumour progression and may have prognostic value.
Matrix metalloproteinase-2 and -9 secreted by leukemic cells increase the permeability of blood-brain barrier by disrupting tight junction proteins.
Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion.
Matrix metalloproteinase-9 overexpression is closely related to poor prognosis in patients with colon cancer.
Matrix metalloproteinases and metastatic cancer.
Matrix metalloproteinases in human melanoma cell lines and xenografts: increased expression of activated matrix metalloproteinase-2 (MMP-2) correlates with melanoma progression.
MDA-9/syntenin: a positive gatekeeper of melanoma metastasis.
Mechanistic investigations of matrix metalloproteinase-8 inhibition by metal abstraction peptide.
Membrane type (MT) 1-matrix metalloproteinase (MMP) and MMP-2 expression in ligature-induced periodontitis in the rat.
Membrane-Type 4 Matrix Metalloproteinase (MT4-MMP) induces lung metastasis by alteration of primary breast tumor vascular architecture.
Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases.
Membranous type matrix metalloproteinase 16 induces human prostate cancer metastasis.
Metastasis is strongly reduced by the matrix metalloproteinase inhibitor Galardin in the MMTV-PymT transgenic breast cancer model.
Metastatic and non-metastatic colorectal cancer (CRC) cells induce host metalloproteinase production in vivo.
Methicillin-Resistant Staphylococcus Aureus infection exacerbates NSCLC cell metastasis by up-regulating TLR4/MyD88 pathway.
Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers.
Microarray and proteomic analysis of breast cancer cell and osteoblast co-cultures: the role of osteoblast matrix metalloproteinase (MMP)-13 in bone metastasis.
Micronutrient synergy--a new tool in effective control of metastasis and other key mechanisms of cancer.
MicroRNA-491 is involved in metastasis of hepatocellular carcinoma by inhibitions of matrix metalloproteinase and epithelial to mesenchymal transition.
microRNA-9 targets matrix metalloproteinase 14 to inhibit invasion, metastasis, and angiogenesis of neuroblastoma cells.
MicroRNA?299?5p inhibits cell metastasis in breast cancer by directly targeting serine/threonine kinase 39.
Minimally invasive colorectal resection is associated with significantly elevated levels of plasma matrix metalloproteinase 3 (MMP-3) during the first month after surgery which may promote the growth of residual metastases.
miR?133a suppresses cell proliferation, migration and invasion in human lung cancer by targeting MMP?14.
Mitogen-activated protein kinase (MAPK) regulates the expression of progelatinase B (MMP-9) in breast epithelial cells.
MMI-166, a selective matrix metalloproteinase inhibitor, promotes apoptosis in human pancreatic cancer.
MMP-2 as a putative biomarker for carcinomatosis in gastric cancer.
Modification and Biological Evaluation of a Series of 1,5-Diaryl-1,2,4-triazole Compounds as Novel Agents against Pancreatic Cancer Metastasis through Targeting Myoferlin.
Molecular docking and inhibition of matrix metalloproteinase-2 by novel difluorinatedbenzylidene curcumin analog.
MT1G is Silenced by DNA Methylation and Contributes to the Pathogenesis of Hepatocellular Carcinoma.
MT4-MMP promotes invadopodia formation and cell motility in FaDu head and neck cancer cells.
Myricetin suppresses breast cancer metastasis through down-regulating the activity of matrix metalloproteinase (MMP)-2/9.
New biochemical insight of conserved water molecules at catalytic and structural Zn(2+) ions in human matrix metalloproteinase-I: a study by MD-simulation.
New directions for radiation biology research in cancer of the uterine cervix.
New oral chemotherapeutic agents for lung cancer.
Notch1 signaling pathway participates in cancer invasion by regulating MMPs in lingual squamous cell carcinoma.
Notch1-MAPK Signaling Axis Regulates CD133(+) Cancer Stem Cell-Mediated Melanoma Growth and Angiogenesis.
Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism.
Novel strategy in breast cancer therapy: Revealing the bright side of ginsenosides.
Oleuropein induces anti-metastatic effects in breast cancer.
Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo.
Organ heterogeneity of host-derived matrix metalloproteinase expression and its involvement in multiple-organ metastasis by lung cancer cell lines.
Orphan nuclear receptor Nur77 promotes colorectal cancer invasion and metastasis by regulating MMP-9 and E-cadherin.
Osteoactivin Regulates Head and Neck Squamous Cell Carcinoma Invasion by Modulating Matrix Metalloproteases.
Osteoclast-derived matrix metalloproteinase-9 directly affects angiogenesis in the prostate tumor-bone microenvironment.
Over-expression of extracellular matrix metalloproteinase inducer in prostate cancer is associated with high risk of prostate-specific antigen relapse after radical prostatectomy.
Overexpression of Bmi-1 contributes to the invasion and metastasis of hepatocellular carcinoma by increasing the expression of matrix metalloproteinase (MMP)?2, MMP-9 and vascular endothelial growth factor via the PTEN/PI3K/Akt pathway.
Overexpression of collagenase 1 (MMP-1) is mediated by the ERK pathway in invasive melanoma cells: role of BRAF mutation and fibroblast growth factor signaling.
Overexpression of EMMPRIN Isoform 2 Is Associated with Head and Neck Cancer Metastasis.
Overexpression of EphA2, MMP-9, and MVD-CD34 in hepatocellular carcinoma: Implications for tumor progression and prognosis.
Overexpression of membrane-type 2 matrix metalloproteinase induced by hypoxia-inducible factor-1? in pancreatic cancer: Implications for tumor progression and prognosis.
Overexpression of MMP21 and MMP28 is associated with gastric cancer progression and poor prognosis.
Paeonol exerts anti-angiogenic and anti-metastatic activities through downmodulation of Akt activation and inactivation of matrix metalloproteinases.
Patients with hepatic breast cancer metastases demonstrate highly specific profiles of matrix metalloproteinases MMP-2 and MMP-9 after SIRT treatment as compared to other primary and secondary liver tumours.
Penta-O-galloyl-beta-D-glucose suppresses prostate cancer bone metastasis by transcriptionally repressing EGF-induced MMP-9 expression.
pH-sensitive tangeretin-ZnO quantum dots exert apoptotic and anti-metastatic effects in metastatic lung cancer cell line.
Pharmacological inhibition of gelatinase B induction and tumor cell invasion.
Phase I/II trial of batimastat, a matrix metalloproteinase inhibitor, in patients with malignant ascites.
Phlorotannins in Ecklonia cava extract inhibit matrix metalloproteinase activity.
Piceatannol-3-O-?-D-glucopyranoside (PG) exhibits in vitro anti-metastatic and anti-angiogenic activities in HT1080 malignant fibrosarcoma cells.
Plastin 1 drives metastasis of colorectal cancer through the IQGAP1/Rac1/ERK pathway.
Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis.
Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice.
Prevention of liver metastasis of human colon cancer by selective matrix metalloproteinase inhibitor MMI-166.
Prognostic impact of tissue inhibitor of matrix metalloproteinase-1 in esophageal carcinoma.
Prognostic significance of expression of matrix metalloproteinase in colorectal adenocarcinomas and their metastases.
Prognostic significance of matrix metalloproteinase-20 overexpression in laryngeal squamous cell carcinoma.
Promotion of hepatocellular carcinoma metastasis through matrix metalloproteinase activation by epithelial-mesenchymal transition regulator twist1.
Proteolytic activity of human lymphoid tumor cells. Correlation with tumor progression.
PYGB siRNA inhibits the cell proliferation of human osteosarcoma cell lines.
Rac1 mediates type I collagen-dependent MMP-2 activation. role in cell invasion across collagen barrier.
Randomised double blind placebo control study of adjuvant treatment with the metalloproteinase inhibitor, Marimastat in patients with inoperable colorectal hepatic metastases: significant survival advantage in patients with musculoskeletal side-effects.
Ras induces experimental lung metastasis through up-regulation of RbAp46 to suppress RECK promoter activity.
Recent Advances in Anti-Metastatic Approaches of Herbal Medicines in 5 Major Cancers: From Traditional Medicine to Modern Drug Discovery.
Recent opportunities in matrix metalloproteinase inhibitor drug design for cancer.
Receptor activator of NF-kappaB ligand enhances breast cancer-induced osteolytic lesions through upregulation of extracellular matrix metalloproteinase inducer/CD147.
Reciprocal activation between MMP-8 and TGF-?1 stimulates EMT and malignant progression of hepatocellular carcinoma.
Recklessness as a hallmark of aggressive cancer.
Recombinant human prothrombin kringle-2 inhibits B16F10 melanoma metastasis through inhibition of neovascularization and reduction of matrix metalloproteinase expression.
Recombinant snake venom metalloproteinase inhibitor BJ46A inhibits invasion and metastasis of B16F10 and MHCC97H cells through reductions of matrix metalloproteinases 2 and 9 activities.
Recombinant TIMP-1-GPI inhibits growth of fibrosarcoma and enhances tumor sensitivity to doxorubicin.
Recombinant viral protein promotes apoptosis and suppresses invasion of ovarian adenocarcinoma cells by targeting ?5?1 integrin to downregulate Akt and MMP-2.
Recombination of CXCR4, VEGF, and MMP-9 predicting lymph node metastasis in human breast cancer.
Redox state of adipose tissue for patients with gastric cancer and its connection with the body mass index and distance from the tumor.
Reduced angiogenesis in peritoneal dissemination of gastric cancer through gelatinase inhibition.
Regulation of DCIS to invasive breast cancer progression by Singleminded-2s (SIM2s).
Regulation of membrane-type 4 matrix metalloproteinase by SLUG contributes to hypoxia-mediated metastasis.
Regulation of MMP-9 by p53 in first trimester cytotrophoblastic cells.
Replication study for reported SNP associations with breast cancer survival.
Resveratrol inhibits heregulin-beta1-mediated matrix metalloproteinase-9 expression and cell invasion in human breast cancer cells.
Reverse transcription-polymerase chain reaction phenotyping of metalloproteinases and inhibitors involved in tumor matrix invasion.
RhoGDI? promotes Sp1/MMP-2 expression and bladder cancer invasion through perturbing miR-200c-targeted JNK2 protein translation.
RNA interference mediated suppression of TRPV6 inhibits the progression of prostate cancer in vitro by modulating cathepsin B and MMP9 expression.
RNA interference screening identifies clathrin-B and cofilin-1 as mediators of MT1-MMP in endometrial cancer.
Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion.
Role of matrix metalloproteinase-9 in transforming growth factor-?1-induced epithelial-mesenchymal transition in esophageal squamous cell carcinoma.
Roles of Rap1 signaling in tumor cell migration and invasion.
S-adenosylmethionine, a methyl donor, up regulates tissue inhibitor of metalloproteinase-2 in colorectal cancer.
Secretion and Expression of Matrix Metalloproteinase-2 and 9 from Bone Marrow Mononuclear Cells in Myelodysplastic Syndrome and Acute Myeloid Leukemia.
Selection of peptide inhibitor to matrix metalloproteinase-2 using phage display and its effects on pancreatic cancer cell lines PANC-1 and CFPAC-1.
Sensitive detection of CD147/EMMPRIN and its expression on cancer cells with electrochemical technique.
Sensitivity of human cord blood cells to tetrachloroethylene: cellular and molecular endpoints.
Short-hairpin RNA-mediated MTA2 silencing inhibits human breast cancer cell line MDA-MB231 proliferation and metastasis.
Significance of semaphorin-3A and MMP-14 protein expression in non-small cell lung cancer.
Silencing of the Metastasis Suppressor RECK by RAS Oncogene Is Mediated by DNA Methyltransferase 3b-Induced Promoter Methylation.
SMYD3 promotes cancer invasion by epigenetic upregulation of the metalloproteinase MMP-9.
Solution structure and backbone dynamics of the catalytic domain of matrix metalloproteinase-2 complexed with a hydroxamic acid inhibitor.
Solution structure of the catalytic domain of human stromelysin complexed with a hydrophobic inhibitor.
Spontaneous metastasis in matrix metalloproteinase 3-deficient mice.
Starfish polysaccharides downregulate metastatic activity through the MAPK signaling pathway in MCF-7 human breast cancer cells.
Strobilanthes crispus inhibits migration, invasion and metastasis in breast cancer.
Stromelysin-1 (MMP-3) is inducible in T lymphoma cells and accelerates the growth of lymphoid tumors in vivo.
Structural insights into the binding of MMP9 inhibitors.
Study on extracellular matrix metalloproteinase inducer and human epidermal growth factor receptor-2 protein expression in papillary thyroid carcinoma using a quantum dot-based immunofluorescence technique.
Sublethal irradiation promotes the metastatic potential of hepatocellular carcinoma cells.
Suppression of matrilysin inhibits colon cancer cell invasion in vitro.
Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by bergamottin via the inhibition of protein kinase Cdelta/p38 mitogen-activated protein kinase and JNK/nuclear factor-kappaB-dependent matrix metalloproteinase-9 expression.
Suppressive effect of calcipotriol on the induction of matrix metalloproteinase (MMP)-9 and MMP-13 in a human squamous cell carcinoma cell line.
Synthesis and preliminary biological evaluation of new radioiodinated MMP inhibitors for imaging MMP activity in vivo.
Tangeretin, a citrus pentamethoxyflavone, exerts cytostatic effect via p53/p21 up-regulation and suppresses metastasis in 7,12-dimethylbenz(?)anthracene-induced rat mammary carcinoma.
Targeting CCR2 with its antagonist suppresses viability, motility and invasion by downregulating MMP-9 expression in non-small cell lung cancer cells.
Targeting invadopodia-mediated breast cancer metastasis by using ABL kinase inhibitors.
Targeting of an antecedent proteinase by an activatable probe with deep tissue penetration facilitates early visualization and dynamic malignancy evaluation of orthotopic pancreatic ductal adenocarcinoma (PDAC).
Tauroursodeoxycholic acid reduces the invasion of MDA-MB-231 cells by modulating matrix metalloproteinases 7 and 13.
Tetraspanin CD9 promotes the invasive phenotype of human fibrosarcoma cells via upregulation of matrix metalloproteinase-9.
The altered glucose metabolism in tumor and a tumor acidic microenvironment associated with extracellular matrix metalloproteinase inducer and monocarboxylate transporters.
The anti-metastatic activity of collagenase-2 in breast cancer cells is mediated by a signaling pathway involving decorin and miR-21.
The effect of tomatine on metastasis related matrix metalloproteinase (MMP) activities in breast cancer cell model.
The fibrinolytic factor tPA drives LRP1-mediated melanoma growth and metastasis.
The glycocalyx and its significance in human medicine.
The Goal of Cancer Treatment.
The inhibitory effect of matrix metalloproteinase inhibitor ONO-4817 on lymph node metastasis in tongue carcinoma.
The interplay of matrix metalloproteinase-8, transforming growth factor-?1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma.
The intranuclear PEX domain of MMP involves proliferation, migration, and metastasis of aggressive adenocarcinoma cells.
The Kazal motifs of RECK protein inhibit MMP-9 secretion and activity and reduce metastasis of lung cancer cells in vitro and in vivo.
The many faces of EMMPRIN-Roles in neuroinflammation.
The matrix metalloproteinase inhibitor batimastat inhibits angiogenesis in liver metastases of B16F1 melanoma cells.
The matrix metalloproteinase inhibitor batimastat inhibits the lung colonisation of orthotopically implanted malignant pancreatic tumor cells in SCID mice.
The matrix metalloproteinase system in oral squamous cell carcinoma.
The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers.
The metastasis-associated metalloproteinase stromelysin-3 is induced by transforming growth factor-beta in osteoblasts and fibroblasts.
The microvesicle as a vehicle for EMMPRIN in tumor-stromal interactions.
The other side of MMPs: protective roles in tumor progression.
The overexpression and predictive significance of MMP-12 in esophageal squamous cell carcinoma.
The phosphorylation of CD147 by Fyn plays a critical role for melanoma cells growth and metastasis.
The role of CD44 and matrix metalloproteinase-9 expression in predicting neck metastasis of supraglottic laryngeal carcinoma.
The role of EMMPRIN expression in ovarian epithelial carcinomas.
The role of matrix metalloproteinase-2 promoter polymorphisms in coronary artery disease and myocardial infarction.
The role of proteolytic enzymes in the pathology of epithelial ovarian carcinoma.
The Stromal Overexpression of CD10 in Invasive Breast Cancer and its Association with Clincophathologic Factors.
The Trinity of Matrix Metalloproteinases, Inflammation, and Cancer: A Literature Review of Recent Updates.
The tumor suppressor RECK interferes with HER-2/Neu dimerization and attenuates its oncogenic signaling.
Thrombin generation and the pathogenesis of cancer.
Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential.
TIMP-1 Overexpression in Lung Carcinoma Enhances Tumor Kinetics and Angiogenesis in Brain Metastasis.
TIMP-2 (tissue inhibitor of metalloproteinase-2) regulates MMP-2 (matrix metalloproteinase-2) activity in the extracellular environment after pro-MMP-2 activation by MT1 (membrane type 1)-MMP.
TIMP3 expression associates with prognosis in colorectal cancer and its novel arylsulfonamide inducer, MPT0B390, inhibits tumor growth, metastasis and angiogenesis.
Tissue inhibitor of matrix metalloproteinase-2 in nasopharyngeal carcinoma.
Tissue inhibitor of metalloproteinase-2 as a multifunctional molecule of which the expression is associated with adverse prognosis of patients with urothelial bladder carcinomas.
Tissue inhibitor of metalloproteinases-4 inhibits but does not support the activation of gelatinase A via efficient inhibition of membrane type 1-matrix metalloproteinase.
Tissue inhibitors of metalloproteinase expression in human breast cancer: TIMP-3 is associated with adjuvant endocrine therapy success.
Transgenic TIMP-1 inhibits simian virus 40 T antigen-induced hepatocarcinogenesis by impairment of hepatocellular proliferation and tumor angiogenesis.
Trefoil Factor 1 Suppresses Epithelial-mesenchymal Transition through Inhibition of TGF-beta Signaling in Gastric Cancer Cells.
Trichostatin A-histone deacetylase inhibitor with clinical therapeutic potential-is also a selective and potent inhibitor of gelatinase A expression.
Tubulin-binding agents down-regulate matrix metalloproteinase-2 and -9 in human hormone-refractory prostate cancer cells - A critical role of Cdk1 in mitotic entry.
Tumor targeting with a selective gelatinase inhibitor.
Tumor vesicle-associated CD147 modulates the angiogenic capability of endothelial cells.
Tumor-recruited M2 macrophages promote gastric and breast cancer metastasis via M2 macrophage-secreted CHI3L1 protein.
Tumour necrosis factor-alpha provokes upregulation of alpha2beta1 and alpha5beta1 integrins, and cell migration in OST osteosarcoma cells.
Unexpected effect of matrix metalloproteinase down-regulation on vascular intravasation and metastasis of human fibrosarcoma cells selected in vivo for high rates of dissemination.
Up-regulated EMMPRIN/CD147 protein expression might play a role in colorectal carcinogenesis and its subsequent progression without an alteration of its glycosylation and mRNA level.
Up-regulation of vascular endothelial growth factor by membrane-type 1 matrix metalloproteinase stimulates human glioma xenograft growth and angiogenesis.
Upregulated Expression of ADAM17 Is a Prognostic Marker for Patients With Gastric Cancer.
Upregulation of circulating cytokeratin 20, urokinase plasminogen activator and C-reactive protein is associated with poor prognosis in gastric cancer.
Upregulation of extracellular matrix metalloproteinase inducer promotes hypoxia-induced epithelial-mesenchymal transition in esophageal cancer.
Upregulation of miR-328 and inhibition of CREB-DNA-binding activity are critical for resveratrol-mediated suppression of matrix metalloproteinase-2 and subsequent metastatic ability in human osteosarcomas.
Upregulation of serum vascular endothelial growth factor and matrix metalloproteinase-3 in patients with oral squamous cell carcinoma.
Ursolic acid and its esters: occurrence in cranberries and other Vaccinium fruit and effects on matrix metalloproteinase activity in DU145 prostate tumor cells.
Use of Edman degradation sequence analysis and matrix-assisted laser desorption/ionization mass spectrometry in designing substrates for matrix metalloproteinases.
Using caffeoyl pyrrolidine derivative LY52, a potential inhibitor of matrix metalloproteinase-2, to suppress tumor invasion and metastasis.
Violacein inhibits matrix metalloproteinase mediated CXCR4 expression: potential anti-tumor effect in cancer invasion and metastasis.
Wild-type p53 gene transfer inhibits invasion and reduces matrix metalloproteinase-2 levels in p53-mutated human melanoma cells.
Wortmannin Reduces Metastasis and Angiogenesis of Human Breast Cancer Cells via Nuclear Factor- B-dependent Matrix Metalloproteinase-9 and Interleukin-8 Pathways.
[An experimental study of matrix metalloproteinase inhibitor BB-94 inhibits the invasion and metastasis of the human salivary adenoid cystic carcinoma in vitro and in vivo]
[Detection of stromelysin mRNA expression in human hepatocellular carcinoma by in situ hybridization]
[Effect of Src tyrosine kinase inhibition on secretion of MMP-2 and MMP-9 by non-small cell lung cancer cells].
[Effects of tamoxifen on apoptosis and matrix metalloproteinase-7 expression in estrogen receptor beta-positive colorectal cancer cell line HT-29]
[Expression and clinical significance of CD147 and MMP-2 ?in squamous cell carcinoma and adenocarcinoma of the lungs].
[Expression of extracellular matrix metalloproteinase inducer in human bladder transitional cell carcinoma]
[Expression of matrix metalloproteinase-2, 9 and it's tissue inhibitor-1, 2 in endometrial carcinoma]
[Expression of trophoblast invasion related genes mRNA and protein in human placenta in preeclampsia]
[Expressions of CD147, MMP-2 and MMP-9 in laryngeal carcinoma and clinical significance]
[How to predict the relapse after surgery or radiofrequency of liver metastases of colorectal cancer? Interest of the serum kinetic variation of a matrix metalloproteinase cluster].
[Increased expression of extracellular matrix metalloproteinase inducer through interaction between fibroblasts and colonic cancer cells]
[Relationship between expression of matrix metalloproteinase (MMP-9) and tumor angiogenesis, cancer cell proliferation, invasion, and metastasis in invasive carcinoma of cervix]
[Relationship between lymph node metastasis and the expressions of E-cadherin, N-cadherin, and matrix metalloproteinase in breast carcinoma]
[Relationship of expression unbalance of matrix metalloproteinase and tissue inhibitor of metalloproteinase to invasiveness and metastasis in gastric carcinomas]
[Role of matrix metalloproteinase (MMP)-2 and -9 and vascular endothelial growth factor C in lymph node metastasis of breast cancer.]
[Significance of caveolin-1 protein detected by quantum dots technique in human lung cancer invasiveness and metastasis.]
[Study of the relation between MMP2, MMP9 and nasopharyngeal carcinoma]
[Therapeutic effect of matrix metalloproteinase inhibitor (R-94138) for peritoneal metastasis of stomach neoplasm models]
[Tumor metastasis and MMP inhibitor.]
ß-1,3-galactosyl-O-glycosyl-glycoprotein ß-1,6-N-acetylglucosaminyltransferase 3 Increases MCAM Stability, Which Enhances S100A8/A9-Mediated Cancer Motility.
Neoplasm Micrometastasis
A third-generation matrix metalloproteinase (MMP) inhibitor (ONO-4817) combined with docetaxel suppresses progression of lung micrometastasis of MMP-expressing tumor cells in nude mice.
Intrahepatic micrometastases around liver metastases from gastric cancer.
Prognostic significance of matrix metalloproteinases type I expression and tumor front parameters in the presence of lymph node micrometastases in carcinoma of the larynx.
[Morphological tumor front grading and matrix metalloproteinases type I expression as a prognostic parameter of the presence of lymph node micrometastases in laryngeal carcinoma]
Neoplasm, Residual
Strategies to eradicate minimal residual disease in small cell lung cancer: high-dose chemotherapy with autologous bone marrow transplantation, matrix metalloproteinase inhibitors, and BEC2 plus BCG vaccination.
Targeting lethal minimal residual disease in small cell lung cancer.
Neoplasms
"Locked" cancer cells are more sensitive to chemotherapy.
'Decoy' and 'non-decoy' functions of DcR3 promote malignant potential in human malignant fibrous histiocytoma cells.
1,25-dihydroxyvitamin D deficiency accelerates alveolar bone loss independent of aging and extracellular calcium and phosphorus.
1?Palmitoyl?2?linoleoyl?3?acetyl?rac?glycerol ameliorates EGF?induced MMP?9 expression by promoting receptor desensitization in MDA?MB?231 cells.
2-Deoxy-L-ribose inhibits the invasion of thymidine phosphorylase-overexpressing tumors by suppressing matrix metalloproteinase-9.
3, 4-dihydroxybenzalacetone attenuates lipopolysaccharide-induced inflammation in acute lung injury via down-regulation of MMP-2 and MMP-9 activities through suppressing ROS-mediated MAPK and PI3K/AKT signaling pathways.
4-Hydroxy-7-oxo-5-heptenoic acid lactone is a potent inducer of brain cancer cell invasiveness that may contribute to the failure of anti-angiogenic therapies.
7,8-Dihydroxyflavone activates Nrf2/HO-1 signaling pathways and protects against osteoarthritis.
?-catenin-activated autocrine PDGF/Src signaling is a therapeutic target in pancreatic cancer.
?3GnT8 plays an important role in CD147 signal transduction as an upstream modulator of MMP production in tumor cells.
A 24-h work shift in intensive care personnel: biological pathways between work stress and ill health.
A Cancer Invasion Model Combined with Cancer-Associated Fibroblasts Aggregates Incorporating Gelatin Hydrogel Microspheres Containing a p53 Inhibitor.
A cancer invasion model of cancer-associated fibroblasts aggregates combined with TGF-?1 release system.
A carcinogenic trigger to study the function of tumor suppressor genes in Schmidtea mediterranea.
A combined inhibitor of matrix metalloproteinase activity and tumour necrosis factor-alpha processing attenuates experimental autoimmune neuritis.
A comparative analysis and systematic review of the wound-healing milieu: implications for body contouring after massive weight loss.
A Competitive ELISA for quantifying serum CD147: reduction of soluble CD147 levels in cancer patient sera.
A complete expression profile of matrix-degrading metalloproteinases in Dupuytren's disease.
A dietary polysaccharide from Eucheuma cottonii downregulates proinflammatory cytokines and ameliorates osteoarthritis-associated cartilage degradation in obese rats.
A dose-finding and pharmacokinetic study of the matrix metalloproteinase inhibitor MMI270 (previously termed CGS27023A) with 5-FU and folinic acid.
A dual inhibitor of matrix metalloproteinases and a disintegrin and metalloproteinases, [¹?F]FB-ML5, as a molecular probe for non-invasive MMP/ADAM-targeted imaging.
A high throughput fluorogenic substrate for interstitial collagenase (MMP-1) and gelatinase (MMP-9).
A high throughput fluorogenic substrate for stromelysin (MMP-3).
A hydroxamic acid-methacrylated collagen conjugate for the modulation of inflammation-related MMP upregulation.
A matrix metalloproteinase activation probe for painting human tumours.
A matrix metalloproteinase expressed on the surface of invasive tumour cells.
A matrix metalloproteinase inhibitor enhances anti-cytotoxic T lymphocyte antigen-4 antibody immunotherapy in breast cancer by reprogramming the tumor microenvironment.
A matrix metalloproteinase inhibitor prevents processing of tumor necrosis factor alpha (TNF alpha) and abrogates endotoxin-induced lethality.
A matrix metalloproteinase inhibitor, ONO-4817, retards the development of mammary tumor and the progression of uterine adenomyosis in mice.
A Model for the Solution Structure of Human Fe(II)-Bound Acireductone Dioxygenase and Interactions with the Regulatory Domain of Matrix Metalloproteinase I (MMP-I).
A natural bacterial-derived product, the metalloprotease arazyme, inhibits metastatic murine melanoma by inducing MMP-8 cross-reactive antibodies.
A new gallium complex inhibits tumor cell invasion and matrix metalloproteinase MMP-14 expression and activity.
A new matrix metalloproteinase-9 inhibitor 3,4-dihydroxycinnamic acid (caffeic acid) from methanol extract of Euonymus alatus: isolation and structure determination.
A new paradigm for mechanobiological mechanisms in tumor metastasis.
A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes.
A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing's sarcoma.
A novel functional site of extracellular matrix metalloproteinase inducer (EMMPRIN) that limits the migration of human uterine cervical carcinoma cells.
A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation.
A novel matrix metalloproteinase inhibitor, FYK-1388 suppresses tumor growth, metastasis and angiogenesis by human fibrosarcoma cell line.
A Novel Nonviral Gene Delivery System: Multifunctional Envelope-Type Nano Device.
A novel peptide blocking cancer cell invasion by structure-based drug design.
A Peptide-Network Weaved Nanoplatform with Tumor Microenvironment Responsiveness and Deep Tissue Penetration Capability for Cancer Therapy.
A phase I and pharmacologic study of the matrix metalloproteinase inhibitor CP-471,358 in patients with advanced solid tumors.
A phase I and pharmacological study of the matrix metalloproteinase inhibitor BB-3644 in patients with solid tumours.
A phase I dose escalation study of the matrix metalloproteinase inhibitor BAY 12-9566 administered orally in patients with advanced solid tumours.
A phase I pharmacokinetic and pharmacodynamic study of s-3304, a novel matrix metalloproteinase inhibitor, in patients with advanced and refractory solid tumors.
A phase I study of oral BMS-275291, a novel nonhydroxamate sheddase-sparing matrix metalloproteinase inhibitor, in patients with advanced or metastatic cancer.
A phase II trial of marimastat in advanced pancreatic cancer.
A phenotype from tumor stroma based on the expression of metalloproteases and their inhibitors, associated with prognosis in breast cancer.
A polysaccharide from mushroom Huaier retards human hepatocellular carcinoma growth, angiogenesis, and metastasis in nude mice.
A prostate secretory protein94-derived synthetic peptide PCK3145 inhibits VEGF signalling in endothelial cells: Implication in tumor angiogenesis.
A PSP94-derived peptide PCK3145 inhibits MMP-9 secretion and triggers CD44 cell surface shedding: implication in tumor metastasis.
A role for endothelin-2 and its receptors in breast tumor cell invasion.
A role for p53 in the regulation of extracellular matrix metalloproteinase inducer in human cancer cells.
A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter is associated with conventional renal cell carcinoma.
A synergistic interaction of transcription factors AP2 and YB-1 regulates gelatinase A enhancer-dependent transcription.
A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts.
A third-generation matrix metalloproteinase (MMP) inhibitor (ONO-4817) combined with docetaxel suppresses progression of lung micrometastasis of MMP-expressing tumor cells in nude mice.
A trend of increase in periodontal interleukin-6 expression across patients with neither diabetes nor periodontal disease, patients with periodontal disease alone, and patients with both diseases.
A tumor environment responsive Doxorubicin-loaded nanoparticle for targeted cancer therapy.
A zinc chelator inhibiting gelatinases exerts potent in vitro anti-invasive effects.
A20 suppresses inflammatory responses and bone destruction in human fibroblast-like synoviocytes and in mice with collagen-induced arthritis.
AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis.
Aberrant expression, processing and degradation of dystroglycan in squamous cell carcinomas.
Abrogation of CC chemokine receptor 9 ameliorates collagen-induced arthritis of mice.
Absence of circulating aldosterone attenuates foreign body reaction around surgical sutures.
Accelerated degradation of collagen membranes in type 1 diabetic rats is associated with increased expression and production of several inflammatory molecules.
Accumulation of differentiating intestinal stem cell progenies drives tumorigenesis.
Acrylamide exposure aggravates the development of ulcerative colitis in mice through activation of NF-?B, inflammatory cytokines, iNOS, and oxidative stress.
Actin-dependent tumour cell adhesion after short-term exposure to the antimetastasis ruthenium complex NAMI-A.
Activation of ALDH2 attenuates high glucose induced rat cardiomyocyte fibrosis and necroptosis.
Activation of cultured rat hepatic stellate cells by tumoral hepatocytes.
Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: a role for inflammatory cells in tumor invasion and angiogenesis.
Activation of protein kinase CK2 is an early step in the ultraviolet B-mediated increase in interstitial collagenase (matrix metalloproteinase-1; MMP-1) and stromelysin-1 (MMP-3) protein levels in human dermal fibroblasts.
Active immunogene therapy of cancer with vaccine on the basis of chicken homologous matrix metalloproteinase-2.
ADAM17 is associated with EMMPRIN and predicts poor prognosis in patients with uterine cervical carcinoma.
ADAM17 promotes the invasion of hepatocellular carcinoma via upregulation MMP21.
ADAMTS-5 Decreases in Aortas and Plasma From Aortic Dissection Patients and Alleviates Angiotensin II-Induced Smooth Muscle-Cell Apoptosis.
Addition of matrix metalloproteinase inhibition to conventional cytotoxic therapy reduces tumor implantation and prolongs survival in a murine model of human pancreatic cancer.
Adenosine diphosphate regulates MMP2 and MMP9 activity in malignant mesothelioma cells.
Adhesive defect in extracellular matrix tenascin-X-null fibroblasts: a possible mechanism of tumor invasion.
Adiponectin mitigates the severity of arthritis in mice with collagen-induced arthritis.
Adipose-derived mesenchymal stem cells promote osteosarcoma proliferation and metastasis by activating the STAT3 pathway.
Adjuvant therapy for gastric carcinoma: closing out the century.
Administration of a matrix metalloproteinase inhibitor after hemorrhage improves cardiovascular and hepatocellular function.
Administration of granulocyte colony-stimulating factor with radiotherapy promotes tumor growth by stimulating vascularization in tumor-bearing mice.
Adrenomedullin protects rat dorsal root ganglion neurons against doxorubicin-induced toxicity by ameliorating oxidative stress.
Age- and gender-dependent myocardial transcription patterns of cytokines and extracellular matrix remodelling enzymes in cats with non-cardiac diseases.
Alendronate regulates cell invasion and MMP-2 secretion in human osteosarcoma cell lines.
ALK5 promotes tumor angiogenesis by upregulating matrix metalloproteinase-9 in tumor cells.
alpha2beta1 integrin signaling via the mitogen activated protein kinase pathway modulates retinoic acid-dependent tumor cell invasion and transcriptional downregulation of matrix metalloproteinase 9 activity.
Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios.
Alterations of gene expression in human neutrophils induced by smoking cessation.
Alterations of the tissue inhibitor of metalloproteinase-3 (TIMP3) gene in pancreatic adenocarcinomas.
Altered metastatic behavior of human breast cancer cells after experimental manipulation of matrix metalloproteinase 8 gene expression.
Altered Protein Composition and Gene Expression in Strabismic Human Extraocular Muscles and Tendons.
Alternative splicing and promoter usage generates an intracellular stromelysin 3 isoform directly translated as an active matrix metalloproteinase.
Alveolar bone protective and hypoglycemic effects of systemic propolis treatment in experimental periodontitis and diabetes mellitus.
Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice.
Amelioration of dextran sulfate sodium-induced colitis by anti-macrophage migration inhibitory factor antibody in mice.
An assessment of MMP and TIMP gene expression in cell lines and stroma - tumour differences in microdissected breast cancer biopsies.
An epitope-specific novel anti-EMMPRIN polyclonal antibody inhibits tumor progression.
An in vivo model for screening peptidomimetic inhibitors of gelatinase A.
An insight to conserved water molecular dynamics of catalytic and structural Zn(+2) ions in matrix metalloproteinase 13 of human.
An NCIC CTG phase I/pharmacokinetic study of the matrix metalloproteinase and angiogenesis inhibitor BAY 12-9566 in combination with 5-fluorouracil/leucovorin.
An NCIC-CTG phase I dose escalation pharmacokinetic study of the matrix metalloproteinase inhibitor BAY 12-9566 in combination with doxorubicin.
An Overview of Matrix Metalloproteinase 9 Polymorphism and Gastric Cancer Risk.
An Unusually Stable G-Quadruplex within the 5'-UTR of the MT3 Matrix Metalloproteinase mRNA Represses Translation in Eukaryotic Cells.
Analysis of ALK, IDH1, IDH2 and MMP8 somatic mutations in differentiated thyroid cancers.
Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer.
Analysis of intra-uterine cytokine concentration and matrix-metalloproteinase activity in women with recurrent failed embryo transfer.
Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma.
Angiogenesis and tumor growth inhibition by a matrix metalloproteinase inhibitor targeting radiation-induced invasion.
Angiogenesis for tumor vascular normalization of Endostar on hepatoma 22 tumor-bearing mice is involved in the immune response.
Angiogenesis inhibition by vascular endothelial growth factor receptor-2 blockade reduces stromal matrix metalloproteinase expression, normalizes stromal tissue, and reverts epithelial tumor phenotype in surface heterotransplants.
Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinases.
Angiopoietin 2 displays a vascular endothelial growth factor dependent synergistic effect in hepatocellular carcinoma development in mice.
Anserine and glucosamine supplementation attenuates the levels of inflammatory markers in rats with rheumatoid arthritis.
Anti-angiogenic effects of somatostatin receptor subtype 2 on human pancreatic cancer xenografts.
Anti-apolipoprotein A-1 IgG in patients with myocardial infarction promotes inflammation through TLR2/CD14 complex.
Anti-Apoptotic and Anti-Inflammatory Activities of Edible Fresh Water Algae Prasiola japonica in UVB-Irradiated Skin Keratinocytes.
Anti-EMMPRIN antibody treatment of head and neck squamous cell carcinoma in an ex-vivo model.
Anti-IL-20 monoclonal antibody inhibited tumor growth in hepatocellular carcinoma.
Anti-inflammatory and Anti-apoptotic Effect of Valproic Acid and Doxycycline Independent from MMP Inhibition in Early Radiation Damage.
Anti-inflammatory and anti-nociceptive effect of Betula platyphylla var. japonica in human interleukin-1?-stimulated fibroblast-like synoviocytes and in experimental animal models.
Anti-invasive activity of anthocyanins isolated from Vitis coignetiae in human hepatocarcinoma cells.
Anti-Osteoarthritic Effects of a Mixture of Dried Pomegranate Concentrate Powder, Eucommiae Cortex, and Achyranthis Radix 5:4:1 (g/g) in a Surgically Induced Osteoarthritic Rabbit Model.
Anti-Vascular Endothelial Growth Factor (VEGF) Antibody Ameliorates Cartilage Degradation in a Rat Model of Chronic Sports Arthritic Injury.
Anticancer and antimetastatic effects of cordycepin, an active component of Cordyceps sinensis.
Antihypertensive and Antifibrosis Effects of Acupuncture at PC6 Acupoints in Spontaneously Hypertensive Rats and the Underlying Mechanisms.
Antimetastatic activity of polyphenol-rich extract of Ecklonia cava through the inhibition of the Akt pathway in A549 human lung cancer cells.
Antineoplastic effects of nutrient mixture on raji and jurkat t cells: the two highly aggressive non hodgkin's lymphoma cell lines.
Antisense E1AF transfection restrains oral cancer invasion by reducing matrix metalloproteinase activities.
Antitumor activity of targeting SRC kinases in endothelial and myeloid cell compartments of the tumor microenvironment.
Antitumor effect of ascorbic acid, lysine, proline, arginine, and green tea extract on bladder cancer cell line T-24.
Antitumor effects of recombinant human adenovirus-p53 against human cutaneous squamous cell carcinoma in mice.
Arg kinase mediates CXCL12/CXCR4-induced invadopodia formation and invasion of glioma cells.
Arsenic enhances matrix metalloproteinase-14 expression in fibroblasts.
Arylsulfonamides and selectivity of matrix metalloproteinase-2: An overview.
Arylsulphonyl hydroxamic acids: potent and selective matrix metalloproteinase inhibitors.
Assay of matrix metalloproteases types 8 and 9 by ELISA in human breast cancer.
Assessment of CMKLR1 level in colorectal cancer and its correlation with angiogenic markers.
ASSESSMENT OF GELATINASE AND TUMOR NECROSIS FACTOR-? LEVEL IN THE VITREOUS AND SERUM OF PATIENTS WITH EALES DISEASE: Role of Inflammation-Mediated Angiogenesis in the Pathogenesis of Eales Disease.
Assessment of MicroRNA (miR)-365 Effects on Oral Squamous Carcinoma Cell Line Phenotypes.
Assignments, secondary structure and dynamics of the inhibitor-free catalytic fragment of human fibroblast collagenase.
Association between Inflammatory Biomarkers and Progression of Intracranial Large Artery Stenosis after Ischemic Stroke.
Association of a haplotype of matrix metalloproteinase (MMP)-1 and MMP-3 polymorphisms with renal cell carcinoma.
Association of BCSC-1 and MMP-14 with human breast cancer.
Association of CD44 V3-containing isoforms with tumor cell growth, migration, matrix metalloproteinase expression, and lymph node metastasis in head and neck cancer.
Association of ets-related transcriptional factor E1AF expression with tumour progression and overexpression of MMP-1 and matrilysin in human colorectal cancer.
Association of functional polymorphisms of matrix metalloproteinase (MMP)-1 and MMP-3 genes with colorectal cancer.
Association of matrilysin expression with progression and poor prognosis in human pancreatic adenocarcinoma.
Association of matrilysin mRNA expression with K-ras mutations and progression in pancreatic ductal adenocarcinomas.
Association of matrilysin-2 (MMP-26) expression with tumor progression and activation of MMP-9 in esophageal squamous cell carcinoma.
Association of matrix metalloproteinase (MMP)-2 and -9 expression with extra-gastrointestinal stromal tumor metastasis.
Association of matrix metalloproteinases 3 and 9 single nucleotide polymorphisms with breast cancer risk: A case-control study.
Atorvastatin attenuates atherosclerotic plaque destabilization by inhibiting endoplasmic reticulum stress in hyperhomocysteinemic mice.
Atorvastatin May Delay Cardiac Aging by Upregulating Peroxisome Proliferator-Activated Receptors in Rats.
Attenuated expression and function of the RECK tumor suppressor under hypoxic conditions is mediated by the MAPK signaling pathways.
Auraptene Inhibits Migration and Invasion of Cervical and Ovarian Cancer Cells by Repression of Matrix Metalloproteinasas 2 and 9 Activity.
Autoantigen-pulsed dendritic cells constitute a beneficial cytokine and growth factor network in ameliorating experimental allergic encephalomyelitis.
Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates matrix metalloproteinase-2 and CD44 in cyclooxygenase-2-dependent invasion.
Autofluorescent gelatin nanoparticles as imaging probes to monitor matrix metalloproteinase metabolism of cancer cells.
Autologous Adipose-Derived Mesenchymal Stem Cells Combined with Shockwave Therapy Synergistically Ameliorates the Osteoarthritic Pathological Factors in Knee Joint.
Autotaxin levels in serum and bronchoalveolar lavage fluid are associated with inflammatory and fibrotic biomarkers and the clinical outcome in patients with acute respiratory distress syndrome.
Basement membrane remodeling is essential for Drosophila disc eversion and tumor invasion.
Basigin (murine EMMPRIN) stimulates matrix metalloproteinase production by fibroblasts.
Basigin-2 is a cell surface receptor for soluble basigin ligand.
Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding.
Batimastat, a synthetic inhibitor of matrix metalloproteinases, potentiates the antitumor activity of cisplatin in ovarian carcinoma xenografts.
Beneficial effects of treatment with transglutaminase inhibitor cystamine on macrophage response in NZB/W F1 mice.
Berberine reverses epithelial-mesenchymal transition and modulates histone methylation in osteosarcoma cells.
Bio-inspired polymer envelopes around adenoviral vectors to reduce immunogenicity and improve in vivo kinetics.
Biochemical and spectroscopic characterization of the catalytic domain of MMP16 (cdMMP16).
Biodegradable interstitial release polymer loading a novel small molecule targeting Axl receptor tyrosine kinase and reducing brain tumour migration and invasion.
Biological activity and clinical implications of the matrix metalloproteinases.
Biological Characteristics of Cluster of Differentiation 147 and Its Relationship with Tumour.
Biological strategies for osteoarthritis: from early diagnosis to treatment.
Biomarkers in dysplasia of the oral cavity: A systematic review.
Bioprinting of patient-derived in vitro intrahepatic cholangiocarcinoma tumor model: establishment, evaluation and anti-cancer drug testing.
Bismaleimide cross-linked anthrax toxin forms functional octamers with high specificity in tumor targeting.
Bisphosphonates and cancer.
Black tea theaflavins attenuate Porphyromonas gingivalis virulence properties, modulate gingival keratinocyte tight junction integrity and exert anti-inflammatory activity.
Blockade of Asparagine Endopeptidase Inhibits Cancer Metastasis.
Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy.
Blockade of Rho/Rho-associated coiled coil-forming kinase signaling can prevent progression of hepatocellular carcinoma in matrix metalloproteinase-dependent manner.
Blocking HOTAIR protects human chondrocytes against IL-1?-induced cell apoptosis, ECM degradation, inflammatory response and oxidative stress via regulating miR-222-3p/ADAM10 axis.
Blood Droplet-Based Cancer Diagnosis via Proteolytic Activity Measurement in Cancer Progression.
Blood-brain barrier function in cerebral malaria and CNS infections in Vietnam.
BMS-275291. Bristol-Myers Squibb.
Bone marrow-derived cells and epithelial tumours: more than just an inflammatory relationship.
Bone-Seeking Matrix Metalloproteinase Inhibitors for the Treatment of Skeletal Malignancy.
Bortezomib attenuates murine collagen-induced arthritis.
Caffeic acid phenethyl ester inhibits invasion and expression of matrix metalloproteinase in SK-Hep1 human hepatocellular carcinoma cells by targeting nuclear factor kappa B.
Caffeoyl pyrrolidine derivative LY52 inhibits tumor invasion and metastasis via suppression of matrix metalloproteinase activity.
Can matrix metalloproteinase inhibitors provide a realistic therapy in cardiovascular medicine?
Cancer biology: extracellular proteinases in malignancy.
Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors.
Cancer stem-like cells of glioblastoma characteristically express MMP-13 and display highly invasive activity.
Cancer-derived matrix metalloproteinase-9 contributes to tumor tolerance.
Canine spontaneous head and neck squamous cell carcinomas represent their human counterparts at the molecular level.
Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression.
Carnosine Prevents Type 2 Diabetes-Induced Osteoarthritis Through the ROS/NF-?B Pathway.
Carvacrol Ameliorates Ligation-Induced Periodontitis in Rats.
Case of primary malignant hemangiopericytoma of the heart expressing basement membrane-degradable enzymes.
Cathepsin B-degradable, NIR-responsive nanoparticulate platform for target-specific cancer therapy.
Caveolin-1 regulating the invasion and expression of matrix metalloproteinase (MMPs) in pancreatic carcinoma cells.
Caveolin-1 up-regulates CD147 glycosylation and the invasive capability of murine hepatocarcinoma cell lines.
CCR5 silencing reduces inflammatory response, inhibits viability, and promotes apoptosis of synovial cells in rat models of rheumatoid arthritis through the MAPK signaling pathway.
CD147 (EMMPRIN/Basigin) in kidney diseases: from an inflammation and immune system viewpoint.
CD147 deficiency blocks IL-8 secretion and inhibits lung cancer-induced osteoclastogenesis.
CD147 depletion down-regulates matrix metalloproteinase-11, vascular endothelial growth factor-A expression and the lymphatic metastasis potential of murine hepatocarcinoma Hca-F cells.
CD147 expression correlates with lymph node metastasis in T1-T2 squamous cell carcinoma of the tongue.
CD147 Expression Indicates Unfavourable Prognosis in Prostate Cancer.
CD147 induces up-regulation of vascular endothelial growth factor in U937-derived foam cells through PI3K/AKT pathway.
CD147 overexpression is a prognostic factor and a potential therapeutic target in bladder cancer.
CD147 regulates vascular endothelial growth factor-A expression, tumorigenicity, and chemosensitivity to curcumin in hepatocellular carcinoma.
CD147/basigin promotes progression of malignant melanoma and other cancers.
CD147/EMMPRIN and CD44 are Potential Therapeutic Targets for Metastatic Prostate Cancer.
CD147/EMMPRIN overexpression and prognosis in cancer: A systematic review and meta-analysis.
CD24 suppresses malignant phenotype by downregulation of SHH transcription through STAT1 inhibition in breast cancer cells.
CD40 plays a crucial role in lipopolysaccharide-induced acute lung injury.
CD44(+) gastric cancer cells with stemness properties are chemoradioresistant and highly invasive.
CD44v(3,8-10) is involved in cytoskeleton-mediated tumor cell migration and matrix metalloproteinase (MMP-9) association in metastatic breast cancer cells.
CD44v6 increases gastric cancer malignant phenotype by modulating adipose stromal cell-mediated ECM remodeling.
CD73 complexes with emmprin to regulate MMP-2 production from co-cultured sarcoma cells and fibroblasts.
Celastrol Inhibits Breast Cancer Cell Invasion via Suppression of NF-?B-mediated Matrix Metalloproteinase-9 Expression.
Cell Specific Matrix Metalloproteinase-1 Regulates Lung Metastasis Synergistically with Smoke Exposure.
Cell surface association of matrix metalloproteinase-9 (gelatinase B).
Cell surface remodeling by plasmin: a new function for an old enzyme.
Cell-based gene therapy modifies matrix remodeling after a myocardial infarction in tissue inhibitor of matrix metalloproteinase-3-deficient mice.
Cell-based identification of natural substrates and cleavage sites for extracellular proteases by SILAC proteomics.
Cells behaving badly: a theoretical model for the Fas/FasL system in tumour immunology.
Cellular localization of EMMPRIN predicts prognosis of patients with operable lung adenocarcinoma independent from MMP-2 and MMP-9.
Changes in biochemical parameters after anterior cruciate ligament injury.
Changes in Inflammatory Cytokines in Saliva after Non-Surgical Periodontal Therapy: A Systematic Review and Meta-Analysis.
Changes of gene expression after bone marrow cell transfusion in rats with monocrotaline-induced pulmonary hypertension.
Changes of synovial fluid biomarker levels after opening wedge high tibial osteotomy in patients with knee osteoarthritis.
Characterisation of tumour-derived microvesicles in cancer patients' blood and correlation with clinical outcome.
Characterization of matrix metalloproteinase inhibitors: angiogenesis and tumor models.
Characterization of structural determinants and molecular mechanisms involved in pro-stromelysin-3 activation by 4-aminophenylmercuric acetate and furin-type convertases.
Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases.
Chemical biology for understanding matrix metalloproteinase function.
Chemotherapy based on "Domino-effect" combined with immunotherapy amplifying the efficacy of an anti-metastatic treatment.
Chemotherapy-Enriched THBS2-Deficient Cancer Stem Cells Drive Hepatocarcinogenesis through Matrix Softness Induced Histone H3 Modifications.
Chimeric anti-IL-17 full-length monoclonal antibody is a novel potential candidate for the treatment of rheumatoid arthritis.
Chlamydia pneumoniae enhances cytokine-stimulated human monocyte matrix metalloproteinases through a prostaglandin E2-dependent mechanism.
Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression.
Chlorotoxin modified morusin-PLGA nanoparticles for targeted glioblastoma therapy.
Chronic Exposure of Renal Stem Cells to Inorganic Arsenic Induces a Cancer Phenotype.
Chymase inhibition attenuates lipopolysaccharide/ d-galactosamine-induced acute liver failure in hamsters.
Circulating MMP2 and MMP9 in breast cancer -- potential role in classification of patients into low risk, high risk, benign disease and breast cancer categories.
Citrus auraptene targets translation of MMP-7 (matrilysin) via ERK1/2-dependent and mTOR-independent mechanism.
Clinical and experimental role of ring finger protein 180 on lymph node metastasis and survival in gastric cancer.
Clinical and immunological peri-implant parameters among cigarette and electronic smoking patients treated with photochemotherapy: A randomized controlled clinical trial.
Clinical implications and prognostic value of EMMPRIN/CD147 and MMP2 expression in pediatric gliomas.
Clinical significance of tissue inhibitor of metalloproteinase expression in gastric carcinoma.
Clinical study of systemic chemotherapy combined with bronchoscopic interventional cryotherapy in the treatment of lung cancer.
Clinical trials of a low molecular weight matrix metalloproteinase inhibitor in cancer.
Clinicopathological significance of human macrophage metalloelastase expression in esophageal squamous cell carcinoma.
Clonal variation in phenotype and life span of human embryonic fibroblasts (MRC-5) transduced with the catalytic component of telomerase (hTERT).
COBRA™: a highly potent conditionally active T cell engager engineered for the treatment of solid tumors.
Codelivery of Anti-PD-1 Antibody and Paclitaxel with Matrix Metalloproteinase and pH Dual-Sensitive Micelles for Enhanced Tumor Chemoimmunotherapy.
Cold-inducible RNA-binding protein plays a central role in the pathogenesis of abdominal aortic aneurysm in a murine experimental model.
Collagenase-3 (MMP-13) expression in chondrosarcoma cells and its regulation by basic fibroblast growth factor.
Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas.
Collagenases (MMP-1, -8 and -13) and trypsinogen-2 in fluid from benign and malignant ovarian cysts.
Colorectal Cancer and Mitochondrial Dysfunctions of the Adjunct Adipose Tissues: A Case Study.
Colorectal cancer or colon and rectal cancer? Clinicopathological comparison between colonic and rectal carcinomas.
Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice.
Combination therapy including a gelatinase inhibitor and cytotoxic agent reduces local invasion and metastasis of murine Lewis lung carcinoma.
Combined analysis of studies of the effects of the matrix metalloproteinase inhibitor marimastat on serum tumor markers in advanced cancer: selection of a biologically active and tolerable dose for longer-term studies.
Combined effects of tumor necrosis factor-? and interleukin-1? on lysyl oxidase and matrix metalloproteinase expression in human knee synovial fibroblasts
Combined inhibition of EMMPRIN and epidermal growth factor receptor prevents the growth and migration of head and neck squamous cell carcinoma cells.
Comparative expression of matrix metalloproteinases in internal malignancies and paired cutaneous metastatic lesions.
Comparative Profiling of Metastatic 4T1- vs. Non-metastatic Py230-Based Mammary Tumors in an Intraductal Model for Triple-Negative Breast Cancer.
Comparative Role of Matrixins in Diagnostics of Parotid Gland Tumors.
Comparative studies of potential cancer biomarkers carbon-11 labeled MMP inhibitors (S)-2-(4'-[11C]methoxybiphenyl-4-sulfonylamino)-3-methylbutyric acid and N-hydroxy-(R)-2-[[(4'-[11C]methoxyphenyl)sulfonyl]benzylamino]-3-methylbutanamide.
Comparison of biomarkers in serum and induced sputum of patients with occupational asthma and chronic obstructive pulmonary disease.
Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group.
Comparison of gene expression between metastatic derivatives and their poorly metastatic parental cells implicates crucial tumor-environment interaction in metastasis of head and neck squamous cell carcinoma.
Comparison of matrix metalloproteinase expression between primary tumors with or without liver metastasis in pancreatic and colorectal carcinomas.
Comparison of p38MAPK (mitogene activated protein kinase), p65 NFkappaB (nuclear factor kappa b) and EMMPRIN (extracellular matrix metalloproteinase inducer) expressions with tumor grade and stage of superficial and invasive bladder tumors.
Comparison of Serum and Cervical Cytokine Levels throughout Pregnancy between Preterm and Term Births.
Comparison of the Effects of Matrix Metalloproteinase Inhibitors on TNF-? Release from Activated Microglia and TNF-? Converting Enzyme Activity.
Complex regulation of pulmonary inflammation and fibrosis by CCL18.
Complex Regulation of the Pericellular Proteolytic Microenvironment during Tumor Progression and Wound Repair: Functional Interactions between the Serine Protease and Matrix Metalloproteinase Cascades.
Computational insights into the identification of a potent matrix metalloproteinase inhibitor from Indigofera aspalathoides to control cancer metastasis.
Contributions of Thyroid Hormone to Cancer Metastasis.
Control of matrix metalloproteinase activity in cancer.
Controlling tumor angiogenesis and metastasis of C26 murine colon adenocarcinoma by a new matrix metalloproteinase inhibitor, KB-R7785, in two tumor models.
Correlation among 16 biological factors [p53, p21(waf1), MIB-1 (Ki-67), p16(INK4A), cyclin D1, E-cadherin, Bcl-2, TNF-?, NF-?B, TGF-?, MMP-7, COX-2, EGFR, HER2/neu, ER, and HIF-1?] and clinical outcomes following curative chemoradiation therapy in 10 patients with esophageal squamous cell carcinoma.
Correlation and prognostic significance of MMP-2 and TFPI-2 differential expression in pancreatic carcinoma.
Correlation between plasma angiopoietin-1, angiopoietin-2 and matrix metalloproteinase-2 in coronary heart disease.
Correlation of Synovial Fluid Biomarkers With Cartilage Pathology and Associated Outcomes in Knee Arthroscopy.
Correlation of Vascular Endothelial Growth Factor Expression With Tumor Recurrence and Poor Prognosis in Patients With pN0 Gastric Cancer.
COX-2, MMP-9, and Noguchi classification provide additional prognostic information about adenocarcinoma of the lung. A study of 117 patients from Brazil.
Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment.
Critical role and its underlying molecular events of the plasminogen receptor, S100A10 in malignant tumor and non-tumor diseases.
CRN2 binds to TIMP4 and MMP14 and promotes perivascular invasion of glioblastoma cells.
Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene.
Crosstalk between mast cells and pancreatic cancer cells contributes to pancreatic tumor progression.
Crosstalk between TGF-? signaling and miRNAs in breast cancer metastasis.
CRP2, a new invadopodia actin bundling factor critically promotes breast cancer cell invasion and metastasis.
Crystal structure of full-length human collagenase 3 (MMP-13) with peptides in the active site defines exosites in the catalytic domain.
CTHRC1 induces non-small cell lung cancer (NSCLC) invasion through upregulating MMP-7/MMP-9.
Culture of human fibrosarcoma HT-1080 cells in presence of fibronectin activates MMP-2.
Curcumin ameliorates left ventricular function in rabbits with pressure overload: inhibition of the remodeling of the left ventricular collagen network associated with suppression of myocardial tumor necrosis factor-alpha and matrix metalloproteinase-2 expression.
Curcumin and tetrahydrocurcumin both prevent osteoarthritis symptoms and decrease the expressions of pro-inflammatory cytokines in estrogen-deficient rats.
Curcumin inhibits adverse psychological stress-induced proliferation and invasion of glioma cells via down-regulating the ERK/MAPK pathway.
Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products.
Curcumin suppresses tumor necrosis factor-?-induced matrix metalloproteinase-2 expression and activity in rat vascular smooth muscle cells via the NF-?B pathway.
Curcumin: a potential candidate for matrix metalloproteinase inhibitors.
Current concepts in the pathogenesis of meningitis caused by Streptococcus pneumoniae.
Current status and future prospects of transforming growth factor-? as a potential prognostic and therapeutic target in the treatment of breast cancer.
CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide.
Cyclin-dependent kinase 9 is required for tumor necrosis factor-alpha-stimulated matrix metalloproteinase-9 expression in human lung adenocarcinoma cells.
Cyclooxygenase Inhibition Limits Blood-Brain Barrier Disruption following Intracerebral Injection of Tumor Necrosis Factor-{alpha} in the Rat.
Cypermethrin Induces the Activation of Rat Primary Microglia and Expression of Inflammatory Proteins.
Cytokine profile in the gingival crevicular fluid of rheumatoid arthritis patients with chronic periodontitis.
Cytokine regulation of the matrix metalloproteinases and their inhibitors in human papillomavirus-18 transformed human prostatic tumor cell lines.
Cytokine Signaling and Matrix Remodeling Pathways Associated with Cardiac Sarcoidosis Disease Activity Defined Using FDG PET Imaging.
Cytokine-regulated expression of collagenase-2 (MMP-8) is involved in the progression of ovarian cancer.
Cytokines, Angiogenesis, and Extracellular Matrix Degradation are Augmented by Oxidative Stress in Endometriosis.
Cytokines, matrix metalloproteases, angiogenic and growth factors in tears of normal subjects and vernal keratoconjunctivitis patients.
Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells.
Cytoskeletal Alteration Is an Early Cellular Response in Pulmonary Epithelium Infected with Aspergillus fumigatus Rather than Scedosporium apiospermum.
DAPT suppresses proliferation and migration of hepatocellular carcinoma by regulating the extracellular matrix and inhibiting the Hes1/PTEN/AKT/mTOR signaling pathway.
DDR2 inhibition reduces migration and invasion of murine metastatic melanoma cells by suppressing MMP2/9 expression through ERK/NF-?B pathway.
Decreased expression of carbonyl reductase 1 promotes ovarian cancer growth and proliferation.
Decursinol angelate blocks transmigration and inflammatory activation of cancer cells through inhibition of PI3K, ERK and NF-kappaB activation.
Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models.
Degradation and Remodeling of Epitaxially Grown Collagen Fibrils.
Deguelin targets multiple oncogenic signaling pathways to combat human malignancies.
Demonstration in vivo that stromelysin-3 functions through its proteolytic activity.
Des-?-carboxyl prothrombin induces matrix metalloproteinase activity in hepatocellular carcinoma cells by involving the ERK1/2 MAPK signalling pathway.
Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3).
Detection of Cancer-Specific Proteases Using Magnetic Relaxation of Peptide-Conjugated Nanoparticles in Biological Environment.
Determination of PNU-248686A, a novel matrix metalloproteinase inhibitor, in human plasma by liquid chromatography-tandem mass spectrometry, following protein precipitation in the 96-well plate format.
Development of a Novel PET Tracer [18F]AlF-NOTA-C6 Targeting MMP2 for Tumor Imaging.
Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid.
Development of matrix metalloproteinase inhibitors in cancer therapy.
Development of putrescine anchored nano-crystalsomes bearing doxorubicin and oleanolic acid: deciphering their role in inhibiting metastatic breast cancer.
Dexamethasone prevents alteration of tight junction-associated proteins and barrier function in porcine choroid plexus epithelial cells after infection with Streptococcus suis in vitro.
Dexamethasone Reduces Cell Adhesion and Migration of T47D Breast Cancer Cell Line.
Diagnostic value of neutrophil gelatinase-associated lipocalin/matrix metalloproteinase-9 pathway in transitional cell carcinoma of the bladder.
Dieckol from Ecklonia cava Regulates Invasion of Human Fibrosarcoma Cells and Modulates MMP-2 and MMP-9 Expression via NF-?B Pathway.
Different effects of commonly prescribed statins on abdominal aortic aneurysm wall biology.
Different expression patterns of MMP-2 and MMP-9 in breast cancer.
Differential effect of the expression of TGF-? pathway inhibitors, Smad-7 and Ski, on invasive breast carcinomas: relation to biologic behavior.
Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: role in epithelio-stromal interactions and matrix metalloproteinase induction.
Differential expression of matrix metalloproteinase (MMP)-2, MMP-9 and tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 in non-melanoma skin cancer: implications for tumour progression.
Differential expression of matrix metalloproteinase (MMP)-2, MMP-9, and membrane type 1-MMP in hepatocellular and pancreatic adenocarcinoma: implications for tumor progression and clinical prognosis.
Differential expression patterns of MMPs and their role in the invasion of epithelial premalignant tumors and invasive cutaneous squamous cell carcinoma.
Differential inductions of matrix metalloproteinase-2 and -9 in host tissues during the growth of ascitic sarcoma 180 cells in mice.
Differential patterns of stromelysin-2 (MMP-10) and MT1-MMP (MMP-14) expression in epithelial skin cancers.
Differential regulation of gastric tumor growth by cytokines that signal exclusively through the coreceptor gp130.
Differential regulation of matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2 expression in co-cultures of prostate cancer and stromal cells.
Differential regulation of matrix metalloproteinases in human cancer cells by exogenous factors.
Differing effects of endogenous and synthetic inhibitors of metalloproteinases on intestinal tumorigenesis.
Direct Activation of Emmprin and Associated Pathogenesis by an Oncogenic Herpesvirus.
Direct and indirect markers of cartilage metabolism in synovial fluid obtained from dogs with hip dysplasia and correlation with clinical and radiographic variables.
Direct anti-metastatic efficacy by the DNA enzyme Dz13 and downregulated MMP-2, MMP-9 and MT1-MMP in tumours.
Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells.
Direct production of functional matrix metalloproteinase--14 without refolding or activation and its application for in vitro inhibition assays.
Discovery of selective hydroxamic acid inhibitors of tumor necrosis factor-alpha converting enzyme.
Distribution and clinical significance of circulating tumor cells in nasopharyngeal carcinoma.
Distribution of stromelysin-3 mRNA transcripts and microvessels in human breast carcinomas.
Diverse Functions of Plasma PAF-AH in Tumorigenesis.
Diverse matrix metalloproteinase functions regulate cancer amoeboid migration.
Do the levels of tumor makers or proinflammatory cytokines in mid-trimester cervical fluid predict early-stage cervical shortening?
Dose-dependent increases in circulating TGF-alpha and other EGFR ligands act as pharmacodynamic markers for optimal biological dosing of cetuximab and are tumor independent.
Downregulation of Extracellular Matrix Metalloproteinase Inducer by scFv-M6-1B9 Intrabody Suppresses Cervical Cancer Invasion Through Inhibition of Urokinase-Type Plasminogen Activator.
Downregulation of Integrins in Cancer Cells and Anti-Platelet Properties Are Involved in Holothurian Glycosaminoglycan-Mediated Disruption of the Interaction of Cancer Cells and Platelets in Hematogenous Metastasis.
Downregulation of LGI1 promotes tumor metastasis in esophageal squamous cell carcinoma.
Downregulation of matrix metalloprotease-9 and urokinase plasminogen activator by TX-1877 results in decreased tumor growth and metastasis on xenograft model of rectal cancer.
Doxorubicin conjugates for selective delivery to tumors.
Doxycycline decreases tumor burden in a bone metastasis model of human breast cancer.
Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development.
Drug-induced apoptosis by a matrix metalloproteinase inhibitor, SI-27 on human malignant glioma cell lines; in vitro study.
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors.
Dual functional matrix metalloproteinase-responsive curcumin-loaded nanoparticles for tumor-targeted treatment.
Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals.
Dual role of the arginine methyltransferase CARM1 in the regulation of c-Fos target genes.
Dual targeting of integrin ?v?3 and matrix metalloproteinase-2 for optical imaging of tumors and chemotherapeutic delivery.
Dysregulation of adenosine kinase isoforms in breast cancer.
Dysregulation of FURIN by prostaglandin-endoperoxide synthase 2 in lung epithelial NCI-H292 cells.
Dystroglycan complex in cancer.
E1AF, an ets-oncogene family transcription factor.
Early short-term vagal nerve stimulation attenuates cardiac remodeling after reperfused myocardial infarction.
Ecto-5'-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis.
Effect of 4-[3,5-bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) on the liver metastasis of colon 26-L5 carcinoma cells.
Effect of ?-anhydroicaritin on the expression levels of tumor necrosis factor-? and matrix metalloproteinase-3 in periodontal tissue of diabetic rats.
Effect of a matrix metalloproteinase inhibitor (ONO-4817) on lung metastasis of murine renal cell carcinoma.
Effect of a matrix metalloproteinase inhibitor on host resistance against Listeria monocytogenes infection.
Effect of a nutrient mixture on matrix metalloproteinase-9 dimers in various human cancer cell lines.
Effect of CO2 pneumoperitoneum on the proliferation of human ovarian cancer cell line SKOV-3 and the expression of NM23-H1 and MMP-2.
Effect of cold plasma on periodontal wound healing-an in vitro study.
Effect of cyclosporin A intervention on the immunological mechanisms of coronary heart disease and restenosis.
Effect of Environmental Conditions on the Concentration of Tear Inflammatory Mediators During Contact Lens Wear.
Effect of Gastrodia elata on tumor necrosis factor-alpha-induced matrix metalloproteinase activity in endothelial cells.
Effect of GCSB-5, a Herbal Formulation, on Monosodium Iodoacetate-Induced Osteoarthritis in Rats.
Effect of matrix metalloproteinase inhibition on pancreatic cancer invasion and metastasis: an additive strategy for cancer control.
Effect of matrix metalloproteinase inhibitors on tumor growth and spontaneous metastasis.
Effect of phorbol ester and cytokines on matrix metalloproteinase and tissue inhibitor of metalloproteinase expression in tumor and normal cell lines.
Effect of photodynamic therapy and laser alone as adjunct to scaling and root planing on gingival crevicular fluid inflammatory proteins in periodontal disease: A systematic review.
Effect of Repeated Freezing and Thawing on Biomarker Stability in Plasma and Serum Samples.
Effect of specific silencing of EMMPRIN on the growth and cell cycle distribution of MCF-7 breast cancer cells.
Effect of traditional Chinese medicine Shu-Mai-Tang on attenuating TNFalpha-induced myocardial fibrosis in myocardial ischemia rats.
Effect of tranexamic acid in improving the lifespan of naturally aging mice.
Effect of Ulinastatin Combined With Dexmedetomidine on Postoperative Cognitive Dysfunction in Patients Who Underwent Cardiac Surgery.
Effects and Mechanism of Noninvasive Positive-Pressure Ventilation in a Rat Model of Heart Failure Due to Myocardial Infarction.
Effects of a High-Fat or High-Sucrose Diet on Ultraviolet B Irradiation-Induced Carcinogenesis and Tumor Growth in Melanin-Possessing Hairless Mice.
Effects of a nutrient mixture on immunohistochemical localization of cancer markers in human cervical cancer HeLa cell tumor xenografts in female nude mice.
Effects of a selective cyclooxygenase-2 inhibitor on cancer cells in vitro.
Effects of antioxidant enzyme overexpression on the invasive phenotype of hamster cheek pouch carcinoma cells.
Effects of bromopride on expression of metalloproteinases and interleukins in left colonic anastomoses: an experimental study.
Effects of Calendula officinalis on human gingival fibroblasts.
Effects of chitin and sepia ink hybrid sponge on the healing of burning wound rats and its impact on macrophages in vitro.
Effects of cytokines on matrix metalloproteinase expression in oral squamous cell carcinoma in vitro.
Effects of Edaravone, a Free Radical Scavenger, on Serum Levels of Inflammatory Biomarkers in Acute Brain Infarction.
Effects of Enzymatic Activation on the Distribution of Fluorescently Tagged MMP-2 Cleavable Peptides in Cancer Cells and Spheroids.
Effects of GGCX overexpression on anterior cruciate ligament transection-induced osteoarthritis in rabbits.
Effects of HAb18G/CD147 Knockout on Hepatocellular Carcinoma Cells In Vitro Using a Novel Zinc-Finger Nuclease-Targeted Gene Knockout Approach.
Effects of Hesperidin on H?O?-Treated Chondrocytes and Cartilage in a Rat Osteoarthritis Model.
Effects of inhaled air pollution on markers of integrity, inflammation, and microbiota profiles of the intestines in Apolipoprotein E knockout mice.
Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis-associated properties in A431 cells overexpressing epidermal growth factor receptor.
Effects of LY294002 on the invasiveness of human gastric cancer in vivo in nude mice.
Effects of nanocrystalline silver (NPI 32101) in a rat model of ulcerative colitis.
Effects of Photodynamic Therapy on the Clinical and Gingival Crevicular Fluid Inflammatory Biomarkers in Chronic Periodontitis: A Split-Mouth Randomized Clinical Trial.
Effects of resveratrol and genistein on nuclear factor??B, tumor necrosis factor?? and matrix metalloproteinase?9 in patients with chronic obstructive pulmonary disease.
EGCG inhibited bladder cancer SW780 cell proliferation and migration both in vitro and in vivo via down-regulation of NF-?B and MMP-9.
Elastin-elastases and inflamm-aging.
Elevated activities of MMP-2 in the non-tumorous lung tissues of curatively resected stage I NSCLC patients are associated with tumor recurrence and a poor survival.
Elevated expression levels of androgen receptors and matrix metalloproteinase-2 and -9 in 30 cases of hepatocellular carcinoma compared with adjacent tissues as predictors of cancer invasion and staging.
Elevated expression of both MDR1 and MMP-2 genes in metastasized lymph node of invasive ductal breast cancer.
Elevated expression of hypoxia-inducible factor-2alpha regulated catabolic factors during intervertebral disc degeneration.
Elevated interleukin-12 in pseudosynovial fluid in patients with aseptic loosening of hip prosthesis.
Elevated level of circulating matrix metalloproteinase-9 in patients with lung cancer.
Elevated levels of circulating matrix metalloproteinase-9 in non-small cell lung cancer patients.
Elevated levels of circulating plasma matrix metalloproteinase 9 in non-small cell lung cancer patients.
Elevated levels of Mr 92,000 type IV collagenase during tumor growth in vivo.
Elevated matrix metalloproteinase 7 expression promotes the proliferation, motility and metastasis of tongue squamous cell carcinoma.
Elevated plasma and synovial fluid interleukin-8 and interleukin-18 may be associated with the pathogenesis of knee osteoarthritis.
Emerging Novel Therapeutic Agents in the Treatment of Patients with Gastroesophageal and Gastric Adenocarcinoma.
EMMPRIN (basigin/CD147) expression is not correlated with MMP activity during adult mouse mammary gland development.
Emmprin (basigin/CD147): matrix metalloproteinase modulator and multifunctional cell recognition molecule that plays a critical role in cancer progression.
EMMPRIN (CD147) expression and differentiation of papillary thyroid carcinoma: implications for immunocytochemistry in FNA cytology.
EMMPRIN (CD147), an inducer of matrix metalloproteinase synthesis, also binds interstitial collagenase to the tumor cell surface.
EMMPRIN co-expressed with matrix metalloproteinases predicts poor prognosis in patients with osteosarcoma.
EMMPRIN contributes to the in vitro invasion of human salivary adenoid cystic carcinoma cells.
EMMPRIN Down-regulating miR-106a/b Modifies Breast Cancer Stem-like Cell Properties via Interaction with Fibroblasts Through STAT3 and HIF-1?.
EMMPRIN expression as a prognostic factor in radiotherapy of cervical cancer.
EMMPRIN expression in oral squamous cell carcinomas: correlation with tumor proliferation and patient survival.
EMMPRIN in gynecologic cancers: pathologic and therapeutic aspects.
EMMPRIN Is an Independent Negative Prognostic Factor for Patients with Astrocytic Glioma.
EMMPRIN is associated with S100A4 and predicts patient outcome in colorectal cancer.
EMMPRIN modulates migration and deposition of TN-C in oral squamous carcinoma.
Emmprin promotes anchorage-independent growth in human mammary carcinoma cells by stimulating hyaluronan production.
EMMPRIN reduction via scFv-M6-1B9 intrabody affects ?3?1-integrin and MCT1 functions and results in suppression of progressive phenotype in the colorectal cancer cell line Caco-2.
EMMPRIN silencing inhibits proliferation and perineural invasion of human salivary adenoid cystic carcinoma cells in vitro and in vivo.
EMMPRIN/CD147 deficiency disturbs ameloblast-odontoblast cross-talk and delays enamel mineralization.
EMMPRIN: a novel regulator of leukocyte transmigration into the CNS in multiple sclerosis and experimental autoimmune encephalomyelitis.
Emodin inhibits tumor necrosis factor-?-induced migration and inflammatory responses in rat aortic smooth muscle cells.
Endocrine gland-derived vascular endothelial growth factor strengthens cell invasion ability via prokineticin receptor 2 in colon cancer cell lines.
Endogenous modulators for drug dependence.
Endometrial tumor invasiveness is related to metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 expressions.
Endoneurial remodeling by TNFalph- and TNFalpha-releasing proteases. A spatial and temporal co-localization study in painful neuropathy.
Endostatin binds to the catalytic domain of matrix metalloproteinase-2.
Endostatin inhibits endothelial and tumor cellular invasion by blocking the activation and catalytic activity of matrix metalloproteinase.
Endothelin-1 receptor antagonists prevent the development of pulmonary emphysema in rats.
Endurance Training Depletes Antioxidant System but Does Not Affect Endothelial Functions in Women with Abdominal Obesity: A Randomized Trial with a Comparison to Endurance-Strength Training.
Engineering Cellular Microenvironments with Photo- and Enzymatically Responsive Hydrogels: Toward Biomimetic 3D Cell Culture Models.
Enhanced expression of mRNA for nuclear factor kappaB1 (p50) in CD34+ cells of the bone marrow in rheumatoid arthritis.
Enhanced inhibitory effect of the matrix metalloproteinase inhibitor Ro 28-2653 in combination with estramustine and etoposide on the prostate carcinoma in the rat Dunning orthotopic tumor model.
Enhanced matrix metalloproteinase activity in skeletal muscles of rats with congestive heart failure.
Enhanced production of matrix metalloproteinase-2 in human head and neck carcinomas is correlated with lymph node metastasis.
Enhanced secretion and activation of matrilysin during malignant conversion of human colorectal epithelium and its relationship with invasive potential of colon cancer cells.
Environmental arsenic exposure and serum matrix metalloproteinase-9.
Enzymatic activatable self-assembled peptide nanowire for targeted therapy and fluorescence imaging of tumors.
Enzyme-directed assembly of nanoparticles in tumors monitored by in vivo whole animal imaging and ex vivo super-resolution fluorescence imaging.
Enzyme-Induced Matrix Softening Regulates Hepatocarcinoma Cancer Cell Phenotypes.
EphA2 overexpression is associated with angiogenesis in ovarian cancer.
Epidermal growth factor promotes invasiveness of pancreatic cancer cells through NF-kappaB-mediated proteinase productions.
Epidermal growth factor receptor tyrosine kinase inhibitors and bone metastases: different mechanisms of action for a novel therapeutic application?
Epigallocatechin-3-gallate Increases RXR?-mediated Pro-apoptotic and Anti-invasive Effects in Gastrointestinal Cancer Cell Lines.
Epigallocatechin-3-gallate inhibits photocarcinogenesis through inhibition of angiogenic factors and activation of CD8+ T cells in tumors.
Epigallocatechin-3-gallate inhibits the invasion of human oral cancer cells and decreases the productions of matrix metalloproteinases and urokinase-plasminogen activator.
Epithelial expression of extracellular matrix metalloproteinase inducer/CD147 and matrix metalloproteinase-2 in neoplasms and precursor lesions derived from cutaneous squamous cells: An immunohistochemical study.
Epithelial to mesenchymal transition inducing transcription factors and metastatic cancer.
ERK1/2 and p38 MAP kinase control MMP-2, MT1-MMP, and TIMP action and affect cell migration: A comparison between mesothelioma and mesothelial cells.
ERK1/2 regulate exocytosis through direct phosphorylation of the exocyst component Exo70.
Erythropoietin attenuates ischemia-reperfusion induced lung injury by inhibiting tumor necrosis factor-alpha and matrix metalloproteinase-9 expression.
Estrogen inhibits apoptosis and promotes CC motif chemokine ligand 13 expression on synovial fibroblasts in rheumatoid arthritis.
Etodolac, a selective cyclooxygenase-2 inhibitor, inhibits liver metastasis of colorectal cancer cells via the suppression of MMP-9 activity.
Ets-related protein E1A-F can activate three different matrix metalloproteinase gene promoters.
Eupatilin with PPAR? agonistic effects inhibits TNF?-induced MMP signaling in HaCaT cells.
Euphorbia humifusa Willd exerts inhibition of breast cancer cell invasion and metastasis through inhibition of TNF?-induced MMP-9 expression.
Euterpe oleracea extract inhibits tumorigenesis effect of the chemical carcinogen DMBA in breast experimental cancer.
Evaluation of heparanase and matrix metalloproteinase-9 in patients with cutaneous malignant melanoma.
Evaluation of Local Injection of Bevacizumab against Triple-Negative Breast Cancer Xenograft Tumors.
Evaluation of matrix metalloproteinase type IV-collagenases in serum of patients with tumors of the central nervous system.
Evaluation of matrix metalloproteinase-2 and -9 in the cerebrospinal fluid of dogs with intracranial tumors.
Evaluation of MMP-1, MMP-8, MMP-9 serum levels in patients with adrenal tumors prior to and after surgery.
Evaluation of MMP-9 and MMP-2 and their suppressor TIMP-1 and TIMP-2 in adenocarcinoma of esophagogastric junction.
Exenatide ameliorates inflammatory response in human rheumatoid arthritis fibroblast-like synoviocytes.
Exosomal Tumor MicroRNA Modulates Premetastatic Organ Cells.
Exosomes Derived from miR-143-Overexpressing MSCs Inhibit Cell Migration and Invasion in Human Prostate Cancer by Downregulating TFF3.
Experimental and clinical studies on the use of matrix metalloproteinase inhibitors for the treatment of cancer.
Experimental periodontitis in mice selected for maximal or minimal inflammatory reactions: increased inflammatory immune responsiveness drives increased alveolar bone loss without enhancing the control of periodontal infection.
Expression and Clinical Significance of CD147 in Genitourinary Carcinomas.
Expression and clinical significance of extracellular matrix metalloproteinase inducer, EMMPRIN/CD147, in human osteosarcoma.
Expression and clinical significance of matrix metalloproteinase (MMP)-26 protein in non-small cell lung cancer.
Expression and correlation of Twist and gelatinases in breast cancer.
Expression and function of the chemokine receptor CCR7 in thyroid carcinomas.
Expression and induction of collagenases (MMP-8 and -13) in plasma cells associated with bone-destructive lesions.
Expression and localization of 72 kDa type IV collagenase (MMP-2) in human malignant gliomas in vivo.
Expression and localization of extracellular matrix metalloproteinase inducer in giant cell tumor of bone.
Expression and regulation of collagenase-2 (MMP-8) in head and neck squamous cell carcinomas.
Expression and role of metalloproteinase-2 and endogenous tissue regulator in ameloblastoma.
Expression of adhesion factors and degrading proteins in primary and secondary glioblastomas and their precursor tumors.
Expression of CD147 is associated with prostate cancer progression.
Expression of E1AF, an ets-oncogene transcription factor, highly correlates with malignant phenotype of malignant melanoma through up-regulation of the membrane-type-1 matrix metalloproteinase gene.
Expression of emmprin (CD147), a cell surface inducer of matrix metalloproteinases, in normal human brain and gliomas.
Expression of EMMPRIN and matriptase in esophageal squamous cell carcinoma: correlation with clinicopathological parameters.
Expression of emmprin by oral squamous cell carcinoma.
Expression of EMMPRIN in adenoid cystic carcinoma of salivary glands: correlation with tumor progression and patients' prognosis.
Expression of ets-related transcriptional factor E1AF is associated with tumor progression and over-expression of matrilysin in human gastric cancer.
Expression of extracellular matrix metalloproteinase (MMP-9), E-cadherin and proliferation-associated antigen Ki-67 and their reciprocal correlation in canine mammary adenocarcinomas.
Expression of extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) in pancreatic neoplasm and pancreatic stellate cells.
Expression of extracellular matrix metalloproteinase inducer and enhancement of the production of matrix metalloproteinase-1 in tongue squamous cell carcinoma.
Expression of extracellular matrix metalloproteinase inducer and fascin in urinary bladder cancer: Correlation with clinicopathological characteristics.
Expression of extracellular matrix metalloproteinase inducer in human placenta and fetal membranes at term labor.
Expression of FLJ10540 is correlated with aggressiveness of oral cavity squamous cell carcinoma by stimulating cell migration and invasion through increased FOXM1 and MMP-2 activity.
Expression of human macrophage metalloelastase gene in hepatocellular carcinoma: correlation with angiostatin generation and its clinical significance.
Expression of inducible nitric oxide synthase in mast cells contributes to the regulation of inflammatory cytokines in irritable bowel syndrome with diarrhea.
Expression of KAI1 and tenascin, and microvessel density are closely correlated with liver metastasis of gastrointestinal adenocarcinoma.
Expression of LOXs and MMP-1, 2, 3 by ACL Fibroblasts and Synoviocytes Impact of Coculture and TNF-?.
Expression of matrilysin (matrix metalloproteinase-7) in primary cutaneous and metastatic melanoma.
Expression of matrix metalloproteinase (MMP)-2, MMP-9, MMP-13, and MT1-MMP in skin tumors of human papillomavirus type 8 transgenic mice.
Expression of matrix metalloproteinase (MMP)-7 and MMP-13 and loss of MMP-19 and p16 are associated with malignant progression in chronic wounds.
Expression of Matrix Metalloproteinase 2 and Extracellular Matrix Metalloproteinase Inducer are Unfavorable Postoperative Prognostic Factors in Intrahepatic Cholangiocarcinoma.
Expression of matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) induced by tumour necrosis factor alpha correlates with metastatic ability in a human osteosarcoma cell line.
Expression of matrix metalloproteinase matrilysin (MMP-7) was induced by activated Ki-ras via AP-1 activation in SW1417 colon cancer cells.
Expression of matrix metalloproteinase regulator, RECK, and its clinical significance in osteosarcoma.
Expression of matrix metalloproteinase, tissue inhibitors of metalloproteinase and adhesion molecules in silicotic mice with lung tumor metastasis.
Expression of matrix metalloproteinase-1, -2 and -3 in squamous cell carcinoma and actinic keratosis.
Expression of matrix metalloproteinase-10 in renal cell carcinoma and its prognostic role.
Expression of Matrix Metalloproteinase-13 and Ki-67 in Nonmelanoma Skin Cancer in Xeroderma Pigmentosum and Non-xeroderma Pigmentosum.
Expression of matrix metalloproteinase-2 and -9 and membrane-type 1 matrix metalloproteinase in melanocytic tumors of dogs and canine melanoma cell lines.
Expression of matrix metalloproteinase-2 and -9 and tissue inhibitor of metalloproteinase-1 and -2 in intraductal and nonintraductal growth type of cholangiocarcinoma.
Expression of matrix metalloproteinase-2 and -9 in human ligamentum flavum cells treated with tumor necrosis factor-? and interleukin-1?.
Expression of matrix metalloproteinase-2 in serous borderline ovarian tumors is associated with noninvasive implant formation.
Expression of matrix metalloproteinase-9 in high-grade salivary gland carcinomas is associated with their metastatic potential.
Expression of matrix metalloproteinases (MMPs) in primary human breast cancer and breast cancer cell lines: New findings and review of the literature.
Expression of matrix metalloproteinases in feline vaccine site-associated sarcomas.
Expression of matrix metalloproteinases in supraglottic carcinoma and its clinical implication for estimating lymph node metastases.
Expression of matrix metalloproteinases-2, -8, -13, -26, and tissue inhibitors of metalloproteinase-1 in human osteosarcoma.
Expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) mRNA in trophoblast and endometrial epithelial cell populations of the synepitheliochorial placenta of goats (Capra hircus).
Expression of membrane-type 1, 2, and 3 matrix metalloproteinases messenger RNA in ovarian carcinoma cells in serous effusions.
Expression of membrane-type matrix metalloproteinase-1 in human pancreatic adenocarcinomas.
Expression of metalloproteinases and their tissue inhibitors in squamous cell laryngeal carcinoma.
Expression of MMP-10 in lung cancer.
Expression of MMP-13 is associated with invasion and metastasis of papillary thyroid carcinoma.
Expression of MMP-2, MMP-7, MMP-9, MMP-10 and MMP-11 in human astrocytic and oligodendroglial gliomas.
Expression of MMP-9, MMP-10 and TNF-alpha and lack of epithelial MMP-1 and MMP-26 characterize pyoderma gangrenosum.
Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response.
Expression of MTAP inhibits tumor-related phenotypes in HT1080 cells via a mechanism unrelated to its enzymatic function.
Expression of neutrophil collagenase (matrix metalloproteinase-8) in human atheroma: a novel collagenolytic pathway suggested by transcriptional profiling.
Expression of Receptors for Pituitary-Type Growth Hormone-Releasing Hormone (pGHRH-R) in Human Papillary Thyroid Cancer Cells: Effects of GHRH Antagonists on Matrix Metalloproteinase-2.
Expression of the reversion-inducing cysteine-rich protein with Kazal motifs and matrix metalloproteinase-14 in neuroblastoma and the role in tumour metastasis.
Expression of transforming growth factor-beta 1 and growth in soft agar differentiate prostate carcinoma-associated fibroblasts from normal prostate fibroblasts.
Expression of type IV collagenase correlates with the expression of vascular endothelial growth factor in primary non-small cell lung cancer.
Expression of urokinase plasminogen activator and its receptor in advanced epithelial ovarian cancer patients.
Expression patterns of emmprin and monocarboxylate transporter-1 in ovarian epithelial tumors.
Expression profile of lipoxygenases in gingival tissues of human periodontitis.
Expression profiles associated with aggressive behavior in Merkel cell carcinoma.
Expression profiling of murine intestinal adenomas reveals early deregulation of multiple matrix metalloproteinase (Mmp) genes.
Expressions of CD147, MMP-2 and MMP-9 in Laryngeal Carcinoma and its Correlation with Poor Prognosis.
Expressions of E-cadherin, Cortactin and MMP-9 in Pseudoepitheliomatous Hyperplasia and Squamous Cell Carcinoma of the Head and Neck: Their Relationships with Clinicopathologic Factors and Prognostic Implication.
Expressions of matrix metalloproteinases in early-stage oral squamous cell carcinoma as predictive indicators for tumor metastases and prognosis.
Extracellular matrix (ECM) stiffness and degradation as cancer drivers.
Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim.
Extracellular matrix metalloproteinase inducer (EMMPRIN) is induced upon monocyte differentiation and is expressed in human atheroma.
Extracellular matrix metalloproteinase inducer and matrix metalloproteinase-2 overexpression is associated with loss of hormone receptor expression and poor prognosis in endometrial cancer.
Extracellular matrix metalloproteinase inducer expression has an impact on survival in human bladder cancer.
Extracellular matrix metalloproteinase inducer expression in histological grades of oral squamous cell carcinoma - An immunohistochemical study.
Extracellular matrix metalloproteinase inducer expression in salivary gland tumors: a correlation with microvessel density.
Extracellular Matrix Metalloproteinase Inducer is a Negative Prognostic Factor of Pediatric Medulloblastoma.
Extracellular matrix metalloproteinase inducer stimulates tumor angiogenesis by elevating vascular endothelial cell growth factor and matrix metalloproteinases.
Extracellular matrix metalloproteinase inducer up-regulates the urokinase-type plasminogen activator system promoting tumor cell invasion.
Extracellular matrix metalloproteinase inducer/CD147 promotes myofibroblast differentiation by inducing alpha-smooth muscle actin expression and collagen gel contraction: implications in tissue remodeling.
Extracellular matrix metalloproteinase inducer: a novel poor prognostic marker for human seminomas.
Extracellular matrix remodeling as a regulator of stromal-epithelial interactions during mammary gland development, involution and carcinogenesis.
Factors involved in the pharmacokinetics of COL-3, a matrix metalloproteinase inhibitor, in patients with refractory metastatic cancer: clinical and experimental studies.
Failure of matrix metalloproteinase-9 dimer induction by phorbol 12-myristate 13-acetate in normal human cell lines.
Fe3O4-solamargine induces apoptosis and inhibits metastasis of pancreatic cancer cells.
Features of bilirubin-induced reactive microglia: from phagocytosis to inflammation.
Fenofibrate inhibits tumor necrosis factor-alpha-induced expression of CD40 and matrix metalloproteinase in human vascular endothelial cells.
Fibronectin and cytokines increase JNK, ERK, AP-1 activity, and transin gene expression in rat hepatic stellate cells.
Fibronectin-bound TNF-alpha stimulates monocyte matrix metalloproteinase-9 expression and regulates chemotaxis.
Fibrotic injury after experimental deep vein thrombosis is determined by the mechanism of thrombogenesis.
Fisetin regulates TPA-induced breast cell invasion by suppressing matrix metalloproteinase-9 activation via the PKC/ROS/MAPK pathways.
Flavonoid components in Scutellaria baicalensis inhibit nicotine-induced proliferation, metastasis and lung cancer-associated inflammation in vitro.
FlexPro MD®, a Combination of Krill Oil, Astaxanthin and Hyaluronic Acid, Reduces Pain Behavior and Inhibits Inflammatory Response in Monosodium Iodoacetate-Induced Osteoarthritis in Rats.
Fourteenth Annual Pezcoller Symposium: the novel dichotomy of immune interactions with tumors.
Fullerol nanoparticles suppress inflammatory response and adipogenesis of vertebral bone marrow stromal cells-a potential novel treatment for intervertebral disc degeneration.
Function of alpha3beta1-tetraspanin protein complexes in tumor cell invasion. Evidence for the role of the complexes in production of matrix metalloproteinase 2 (MMP-2).
Functional proteomics study reveals that N-Acetylglucosaminyltransferase V reinforces the invasive/metastatic potential of colon cancer through aberrant glycosylation on tissue inhibitor of metalloproteinase-1.
Functional role of matrix metalloproteinases in ovarian tumor cell plasticity.
Furin-dependent intracellular activation of the human stromelysin-3 zymogen.
Gadolinium metallofullerenol nanoparticles inhibit cancer metastasis through matrix metalloproteinase inhibition: imprisoning instead of poisoning cancer cells.
Galectin-1-mediated tumor invasion and metastasis, up-regulated matrix metalloproteinase expression, and reorganized actin cytoskeletons.
Galectin-3 cleavage: a novel surrogate marker for matrix metalloproteinase activity in growing breast cancers.
Galloyl cyclic-imide derivative CH1104I inhibits tumor invasion through suppressing matrix metalloproteinase activity.
Gamma-aminobutyric acid as a promoting factor of cancer metastasis; induction of matrix metalloproteinase production is potentially its underlying mechanism.
Gastroesophageal cancer, palmar fasciitis and a matrix metalloproteinase inhibitor.
Gefitinib decreases the synthesis of matrix metalloproteinase and the adhesion to extracellular matrix proteins of colon cancer cells.
Gelatin-Encapsulated Magnetic Nanoparticles for pH, Redox, and Enzyme Multiple Stimuli-Responsive Drug Delivery and Magnetic Resonance Imaging.
Gelatinase A activation is regulated by the organization of the polymerized actin cytoskeleton.
Gelatinases and their inhibitors in tumor metastasis: from biological research to medical applications.
Gelatinolytic activity of matrix metalloproteinase in lung cancer studied using film in situ zymography stamp method.
Gelatinolytic activity of matrix metalloproteinase in tumor tissues correlates with the invasiveness of oral cancer.
Gene expression of angiogenic factors correlates with metastatic potential of prostate cancer cells.
Gene therapy of human bladder cancer with adenovirus-mediated antisense basic fibroblast growth factor.
Generation of antitumor peptides by connection of matrix metalloproteinase-9 peptide inhibitor to an endostatin fragment.
Genetic Polymorphism of MMP2 Gene and Susceptibility to Prostate Cancer.
Genetic polymorphisms in chronic obstructive pulmonary disease.
Genetic polymorphisms of matrix metalloproteinases: susceptibility and prognostic implications for prostate cancer.
Genipin inhibits MMP-1 and MMP-3 release from TNF-a-stimulated human periodontal ligament cells.
Genome-wide mRNA and miRNA expression profiling reveal multiple regulatory networks in colorectal cancer.
Ghrelin and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma motility.
Gingival Fluid Inflammatory Biomarkers and Hypertension in African Americans.
Ginkgolide B attenuates collagen-induced rheumatoid arthritis and regulates fibroblast-like synoviocytes-mediated apoptosis and inflammation.
Glioma cell extracellular matrix metalloproteinase inducer (EMMPRIN) (CD147) stimulates production of membrane-type matrix metalloproteinases and activated gelatinase A in co-cultures with brain-derived fibroblasts.
Glycosylation of natural human neutrophil gelatinase B and neutrophil gelatinase B-associated lipocalin.
GM-CSF-transduced B16 melanoma cells are highly susceptible to lysis by normal murine macrophages and poorly tumorigenic in immune-compromised mice.
GM6001 Increases Anastomotic Leakage following Colonic Obstruction Possibly by Impeding Epithelialization.
Gonadotropin-releasing hormone-II increases membrane type I metalloproteinase production via beta-catenin signaling in ovarian cancer cells.
GPDPLQ1237-A Type II Collagen Neo-Epitope Biomarker of Osteoclast- and Inflammation-Derived Cartilage Degradation in vitro.
Group IB secretory phospholipase A2 promotes matrix metalloproteinase-2-mediated cell migration via the phosphatidylinositol 3-kinase and Akt pathway.
Halofuginone suppresses the lung metastasis of chemically induced hepatocellular carcinoma in rats through MMP inhibition.
Ham-Wasserman lecture: role of the plasminogen system in fibrin-homeostasis and tissue remodeling.
Helicobacter pylori strain-selective induction of matrix metalloproteinase-7 in vitro and within gastric mucosa.
Heme oxygenase-1 mediates protective effects on inflammatory, catabolic and senescence responses induced by interleukin-1? in osteoarthritic osteoblasts.
Heparinoids Activate a Protease, Secreted by Mucosa and Tumors, via Tethering Supplemented by Allostery.
Hepatic integrity dependent on matrix metalloproteinase inhibition, not tumor necrosis factor alpha or different bleeding rates.
Hepatocyte growth factor and HER2/neu downregulate expression of apoptosis-inducing factor in non-small cell lung cancer.
Hepatocyte growth factor receptor, matrix metalloproteinase-11, tissue inhibitor of metalloproteinase-1, and fibronectin are up-regulated in papillary thyroid carcinoma: a cDNA and tissue microarray study.
HER-2/neu Represses the Metastasis Suppressor RECK via ERK and Sp Transcription Factors to Promote Cell Invasion.
Herniated and spondylotic intervertebral discs of the human cervical spine: histological and immunohistological findings in 500 en bloc surgical samples. Laboratory investigation.
Heterogeneous activation of MMP-9 due to prostate cancer-bone interaction.
High cancer cell death in syngeneic tumors developed in host mice deficient for the stromelysin-3 matrix metalloproteinase.
High Expression of MMP-9 in Primary Tumors and High Preoperative MPO in Serum Predict Improved Prognosis in Colorectal Cancer with Operable Liver Metastases.
High expression of MMP28 indicates unfavorable prognosis in pancreatic cancer.
High extracellular matrix metalloproteinase inducer/CD147 expression is strongly and independently associated with poor prognosis in colorectal cancer.
High incidence of EMMPRIN expression in human tumors.
High incidence of extracellular matrix metalloproteinase inducer expression in non-small cell lung cancers. Association with clinicopathological parameters.
High levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) in the serum are associated with poor prognosis in HPV-negative squamous cell oropharyngeal cancer.
High Matrix Metalloproteinase 28 Expression is Associated with Poor Prognosis in Pancreatic Adenocarcinoma.
High MMP-21 expression in metastatic lymph nodes predicts unfavorable overall survival for oral squamous cell carcinoma patients with lymphatic metastasis.
High MMP-26 expression in glioma is correlated with poor clinical outcome of patients.
High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis.
High tissue MMP14 expression predicts worse survival in gastric cancer, particularly with a low PROX1.
High-Level Expression and Prognostic Significance of Matrix Metalloprotease-19 and Matrix Metalloprotease-20 in Human Pancreatic Ductal Adenocarcinoma.
High-serum MMP-8 levels are associated with decreased survival and systemic inflammation in colorectal cancer.
Higher risk of matrix metalloproteinase (MMP-2, 7, 9) and tissue inhibitor of metalloproteinase (TIMP-2) genetic variants to gallbladder cancer.
Highly expressed tumoral emmprin and stromal CD73 predict a poor prognosis for external auditory canal carcinoma.
High Glucose and Hypoxia-Mediated Damage to Human Brain Microvessel Endothelial Cells Induces an Altered, Pro-Inflammatory Phenotype in BV-2 Microglia In Vitro.
Hijacking a Morphogenesis Proteinase for Cancer Cell Invasion.
Hinokitiol Exerts Anticancer Activity through Downregulation of MMPs 9/2 and Enhancement of Catalase and SOD Enzymes: In Vivo Augmentation of Lung Histoarchitecture.
Histone Deacetylase (HDAC) 10 Suppresses Cervical Cancer Metastasis through Inhibition of Matrix Metalloproteinase (MMP) 2 and 9 Expression.
Histone deacetylase inhibitors upregulate MMP11 gene expression through Sp1/Smad complexes in human colon adenocarcinoma cells.
HIV Protease Inhibitors Block HPV16-Induced Murine Cervical Carcinoma and Promote Vessel Normalization in Association with MMP-9 Inhibition and TIMP-3 Induction.
Honokiol inhibits non-small cell lung cancer cell migration by targeting PGE?-mediated activation of ?-catenin signaling.
Host CD147 blockade by small interfering RNAs suppresses growth of human colon cancer xenografts.
How molecular imaging is speeding up antiangiogenic drug development.
How the matrix metalloproteinase MMP14 contributes to the progression of colorectal cancer.
HRCT and histopathological evaluation of fibrosis and tissue destruction in IPF associated with pulmonary emphysema.
Human cervical tumor cell (SiHa) surface alphavbeta3 integrin receptor has associated matrix metalloproteinase (MMP-2) activity.
Human keratinocytes express EMMPRIN, an extracellular matrix metalloproteinase inducer.
Hyaluronan-CD44 interaction promotes oncogenic signaling, microRNA functions, chemoresistance, and radiation resistance in cancer stem cells leading to tumor progression.
Hyaluronan-CD44s signaling regulates matrix metalloproteinase-2 secretion in a human lung carcinoma cell line QG90.
Hydrolysis of triple-helical collagen peptide models by matrix metalloproteinases.
Hydroquinone-induced malignant transformation of TK6 cells by facilitating SIRT1-mediated p53 degradation and up-regulating KRAS.
Hypoxia-inducible factor-1 alpha in non small cell lung cancer: relation to growth factor, protease and apoptosis pathways.
Identification and role of the homodimerization interface of the glycosylphosphatidylinositol-anchored membrane type 6 matrix metalloproteinase (MMP25).
Identification of ADAM12 as a Novel Basigin Sheddase.
Identification of an active site of EMMPRIN for the augmentation of matrix metalloproteinase-1 and -3 expression in a co-culture of human uterine cervical carcinoma cells and fibroblasts.
Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues.
Identification of genes showing differential expression in antisense K-ras-transduced pancreatic cancer cells with suppressed tumorigenicity.
Identification of highly selective MMP-14 inhibitory Fabs by deep sequencing.
Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma.
Identification of Proteolytic Cleavage Sites of EphA2 by Membrane Type 1 Matrix Metalloproteinase on the Surface of Cancer Cells.
Iguratimod ameliorates bleomycin-induced alveolar inflammation and pulmonary fibrosis in mice by suppressing expression of matrix metalloproteinase-9.
IL-6 regulates MMP-10 expression via JAK2/STAT3 signaling pathway in a human lung adenocarcinoma cell line.
Imaging matrix metalloproteinase expression in tumors.
Immune complexes containing scleroderma-specific autoantibodies induce a profibrotic and proinflammatory phenotype in skin fibroblasts.
Immunoexpression of MMPs-1, -2, and -9 in ameloblastoma and odontogenic adenomatoid tumor.
Immunohistochemical analysis of matrix metalloproteinase-1, -3, and -13 in naturally occurring cartilaginous tumors of dogs.
Immunohistochemical detection of MT1-MMP, RECK, and EMMPRIN in ameloblastic tumors.
Immunohistochemical expression of epidermal growth factor receptor, E-cadherin, and matrix metalloproteinase-9 in ovarian epithelial cancer and relation to patient deaths.
Immunohistochemical expression of matrix metalloproteinase-2 and -9 in melanocytic nevi is altered by ultraviolet B.
Immunohistochemical levels of cyclo-oxygenase-2, matrix metalloproteinase-9 and vascular endothelial growth factor in papillary thyroid carcinoma and their clinicopathological correlations.
Immunohistochemical Study of Laminin-332 ?2 Chain and MMP-9 in High Risk of Malignant Transformation Oral Lesions and OSCC.
Immunohistochemical study of MT-MMP tissue status in gastric carcinoma and correlation with survival analyzed by univariate and multivariate analysis.
Immunohistochemical study of tumor necrosis factor-alpha, matrix metalloproteinase-12, and tissue inhibitor of metalloproteinase-2 on alveolar macrophages of BALB/c mice exposed to short-term cigarette smoke.
Immunolocalization of MMP-2 and MMP-9 in human rheumatoid synovium.
Immunological and microbiological periodontal profiles in isolated growth hormone deficiency.
Immunological characterization of cell-surface and soluble forms of membrane type 1 matrix metalloproteinase in human breast cancer cells and in fibroblasts.
Immunomodulators plus antibiotics delay preterm delivery after experimental intraamniotic infection in a nonhuman primate model.
Immunomodulatory glc/man-directed Dolichos lablab lectin (DLL) evokes anti-tumour response in vivo by counteracting angiogenic gene expressions.
Immunopathologic characteristics of nasal polyps in adult Koreans: A single-center study.
Immunoscreening of a cutaneous T-cell lymphoma library for plasma membrane proteins.
Impact of a chronic smoking habit on the osteo-immunoinflammatory mediators in the peri-implant fluid of clinically healthy dental implants.
Impact of Bevacizumab on Liver Damage After Massive Hepatectomy in Rats.
Impact of calorie restriction and intermittent fasting on periodontal health.
Impact of Flavonoids on Matrix Metalloproteinase Secretion and Invadopodia Formation in Highly Invasive A431-III Cancer Cells.
Impact of Matrix Metalloproteinase-11 Gene Polymorphisms on Biochemical Recurrence and Clinicopathological Characteristics of Prostate Cancer.
Important immunoregulatory role of interleukin-11 in the inflammatory process in rheumatoid arthritis.
Improvement of liver fibrosis by infusion of cultured cells derived from human bone marrow.
In Situ Protease Secretion Visualization and Metastatic Lymph Nodes Imaging via a Cell Membrane-Anchored Upconversion Nanoprobe.
In vitro analysis of the anticancer properties of scorpion venom in colorectal and breast cancer cell lines.
In vitro and in vivo investigation of matrix metalloproteinase expression in metastatic tumor models.
In Vitro and In Vivo Study on the Toxic Effects of Propiconazole Fungicide in the Pathogenesis of Liver Fibrosis.
In vitro effects of Apixaban on 5 different cancer cell lines.
In vitro inhibition of matrix metalloproteinases, invasion and growth of Fanconi anemia human FANCA and FANCC lymphoblasts by nutrient mixture.
In vitro modulation of MMP-2 and MMP-9 in adult human sarcoma cell lines by cytokines, inducers and inhibitors.
In vitro modulation of MMP-2 and MMP-9 in pediatric human sarcoma cell lines by cytokines, inducers and inhibitors.
In vivo evaluation of matrix metalloproteinase responsive silk-elastinlike protein polymers for cancer gene therapy.
In vivo optical molecular imaging of matrix metalloproteinase activity following celecoxib therapy for colorectal cancer.
In vivo relationship between collagenase-2 and interleukin-8 but not tumour necrosis factor-alpha in chronic rhinosinusitis with nasal polyposis.
In-Silico Characterization and in-Vivo Validation of Albiziasaponin-A, Iso-Orientin, and Salvadorin Using a Rat Model of Alzheimer's Disease.
Inactivation of the tissue inhibitor of metalloproteinases-2 gene by promoter hypermethylation in lymphoid malignancies.
Inclusion complex from cyclodextrin-grafted hyaluronic acid and pseudo protein as biodegradable nano-delivery vehicle for gambogic acid.
Increase of anti-metastatic efficacy by selectivity- but not affinity-optimization of synthetic serine protease inhibitors.
Increased CD40 expression on articular chondrocytes from patients with rheumatoid arthritis: contribution to production of cytokines and matrix metalloproteinases.
Increased expression of Fcgamma receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor alpha and matrix metalloproteinase.
Increased expression of matrix metalloproteinase-2 (MMP-2) predicts tumour recurrence and unfavourable outcome in non-small cell lung cancer.
Increased expression of membrane-type matrix metalloproteinase-1 is correlated with poor prognosis in patients with osteosarcoma.
Increased matrix metalloproteinase-2 expression and reduced tissue factor pathway inhibitor-2 expression correlate with angiogenesis and early postoperative recurrence of pancreatic carcinoma.
Increased peritoneal and endometrial gene expression of biologically relevant cytokines and growth factors during the menstrual phase in women with endometriosis.
Increased precision of orthotopic and metastatic breast cancer surgery guided by matrix metalloproteinase-activatable near-infrared fluorescence probes.
Increased serum TWEAK levels in Psoriatic arthritis: relationship with disease activity and matrix metalloproteinase-3 serum levels.
Increasing production of matrix metalloproteinases, tumor necrosis factor-?, vascular endothelial growth factor and prostaglandin E2 in rheumatoid arthritis synovial fibroblasts by different adiponectin isoforms in a concentration-dependent manner.
Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1.
Induction of matrix metalloproteinases-14 and -2 by cyclical mechanical stretch is mediated by tumor necrosis factor-alpha in cultured human umbilical vein endothelial cells.
Induction of MMP-13 expression by soluble human glucocorticoid-induced tumor necrosis factor receptor in fibroblast-like synovial cells.
Induction of MMP-9 in normal human bronchial epithelial cells by TNF-alpha via NF-kappa B-mediated pathway.
Induction of tumour cell apoptosis by matrix metalloproteinase inhibitors: new tricks from a (not so) old drug.
Inflammation and diabetic retinopathy.
Inflammation and oxidative stress in corneal tissue in experimental keratitis due to Fusarium solani: Amelioration following topical therapy with voriconazole and epigallocatechin gallate.
Inflammatory response to contact lenses in patients with keratoconus compared with myopic subjects.
Inhibiting effects of common trivalent metal ions on transmembrane-type 2 matrix metalloproteinase.
Inhibition activity of sulfated polysaccharide of Sepiella maindroni ink on matrix metalloproteinase (MMP)-2.
Inhibition of ADAM17 reduces hypoxia-induced brain tumor cell invasiveness.
Inhibition of AGS human gastric cancer cell invasion and proliferation by Capsosiphon fulvescens glycoprotein.
Inhibition of angiogenesis and metastasis in two murine models by the matrix metalloproteinase inhibitor, BMS-275291.
Inhibition of angiogenesis and murine hemangioma growth by batimastat, a synthetic inhibitor of matrix metalloproteinases.
Inhibition of arachidonic acid metabolism decreases tumor cell invasion and matrix metalloproteinase expression.
Inhibition of Basigin Expression in Glioblastoma Cell Line via Antisense RNA Reduces Tumor Cell Invasion and Angiogenesis.
Inhibition of breast cancer cell extracellular matrix degradative activity by chemically modified tetracyclines.
Inhibition of CD147 Expression Reduces Tumor Cell Invasion in Human Prostate Cancer Cell Line via RNA Interference.
Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to cisplatin in laryngeal carcinoma Hep2 cells.
Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to paclitaxel in HO-8910pm cells.
Inhibition of CD44 induces apoptosis, inflammation, and matrix metalloproteinase expression in tendinopathy.
Inhibition of cyclo-oxygenase 2 reduces tumor metastasis and inflammatory signaling during blockade of vascular endothelial growth factor.
Inhibition of gelatinase A (MMP-2) by batimastat and captopril reduces tumor growth and lung metastases in mice bearing Lewis lung carcinoma.
Inhibition of gelatinolytic activity in tumor tissues by synthetic matrix metalloproteinase inhibitor: application of film in situ zymography.
Inhibition of HuR and MMP-9 expression in macrophage-differentiated HL-60 myeloid leukemia cells by green tea polyphenol EGCg.
Inhibition of integrin ?1 decreases the malignancy of ovarian cancer cells and potentiates anticancer therapy via the FAK/STAT1 signaling pathway.
Inhibition of invasion and MMPs by a nutrient mixture in human cancer cell lines: a correlation study.
Inhibition of lethal endotoxin shock with an L-pyridylalanine containing metalloproteinase inhibitor selected by high-throughput screening of a new peptide library.
Inhibition of lymphangiogenesis-related properties of murine lymphatic endothelial cells and lymph node metastasis of lung cancer by the matrix metalloproteinase inhibitor MMI270.
Inhibition of matrix metalloproteinase 9 activation by a specific monoclonal antibody.
Inhibition of matrix metalloproteinase activity prevents increases in myocardial tumor necrosis factor-alpha.
Inhibition of matrix metalloproteinase expression by menatetrenone, a vitamin K2 analogue.
Inhibition of matrix metalloproteinase-14 in osteosarcoma cells by clodronate.
Inhibition of matrix metalloproteinase-2 secretion and invasion by human ovarian cancer cell line SK-OV-3 with lysine, proline, arginine, ascorbic acid and green tea extract.
Inhibition of matrix metalloproteinase-9 activity improves coronary outcome in an animal model of Kawasaki disease.
Inhibition of matrix metalloproteinases expression in human dental pulp cells by all-trans retinoic acid.
Inhibition of matrix metalloproteinases-2/-9 transiently reduces pre-oligodendrocyte loss during lipopolysaccharide- but not tumour necrosis factor-alpha-induced inflammation in fetal ovine glial culture.
Inhibition of metalloproteinase and proteasome activities in colon cancer cells by citrus peel extracts.
Inhibition of MMP-9 transcription and suppression of tumor metastasis by pyrrole-imidazole polyamide.
Inhibition of organ invasion by the matrix metalloproteinase inhibitor batimastat (BB-94) in two human colon carcinoma metastasis models.
Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bisphosphonate ibandronate and tissue inhibitor of the matrix metalloproteinase-2.
Inhibition of SOX9 Promotes Inflammatory and Immune Responses of Dental Pulp.
Inhibition of Stat3 Signaling Pathway by Natural Product Pectolinarigenin Attenuates Breast Cancer Metastasis.
Inhibition of the metastatic spread and growth of B16-BL6 murine melanoma by a synthetic matrix metalloproteinase inhibitor.
Inhibition of tumor cell invasion by a highly conserved peptide sequence from the matrix metalloproteinase enzyme prosegment.
Inhibition of vacuolar ATPase subunit in tumor cells delays tumor growth by decreasing the essential macrophage population in the tumor microenvironment.
Inhibitive effect of celecoxib on the adhesion and invasion of human tongue squamous carcinoma cells to extracellular matrix via down regulation of MMP-2 expression.
Inhibitory effect of ?-solanine on esophageal carcinoma in vitro.
Inhibitory effect of a matrix metalloproteinase inhibitor on growth and spread of human pancreatic ductal adenocarcinoma evaluated in an orthotopic severe combined immunodeficient (SCID) mouse model.
Inhibitory effect of caffeic acid phenethyl ester on mice bearing tumor involving angiostatic and apoptotic activities.
Inhibitory effect of Ginkgol C17:1 on the biological behavior of tumor cells.
Inhibitory effect of methanol extract of Euonymus alatus on matrix metalloproteinase-9.
Inhibitory effect of shRNA targeting GPR48 on invasion and metastasis of human cervical carcinoma cell line HeLa.
Inhibitory effects of a benz[f]indole-4,9-dione analog on cancer cell metastasis mediated by the down-regulation of matrix metalloproteinase expression in human HT1080 fibrosarcoma cells.
Inhibitory effects of brusatol delivered using glycosaminoglycan?placental chondroitin sulfate A?modified nanoparticles on the proliferation, migration and invasion of cancer cells.
Inhibitory effects of caffeic acid phenethyl ester on cancer cell metastasis mediated by the down-regulation of matrix metalloproteinase expression in human HT1080 fibrosarcoma cells.
Inhibitory effects of Chanling Gao on the proliferation and liver metastasis of transplanted colorectal cancer in nude mice.
Inhibitory effects of EGb761 on the expression of matrix metalloproteinases (MMPs) and cartilage matrix destruction.
Inotilone from Inonotus linteus suppresses lung cancer metastasis in vitro and in vivo through ROS-mediated PI3K/AKT/MAPK signaling pathways.
Insight into the role of Wnt5a-induced signaling in normal and cancer cells.
Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment.
Intake of grape-derived polyphenols reduces C26 tumor growth by inhibiting angiogenesis and inducing apoptosis.
Intelligently targeted drug delivery and enhanced antitumor effect by gelatinase-responsive nanoparticles.
Interaction between CD147 and P-glycoprotein and their regulation by ubiquitination in breast cancer cells.
Interaction between stromal cells and tumor cells induces chemoresistance and matrix metalloproteinase secretion.
Interactions of tachykinin receptor antagonists with lipopolysaccharide-induced airway inflammation in mice.
Interference with the complement system by tumor cell membrane type-1 matrix metalloproteinase plays a significant role in promoting metastasis in mice.
Interferon-? and celecoxib inhibit lung-tumor growth through modulating M2/M1 macrophage ratio in the tumor microenvironment.
Interferon-beta induces metalloproteinase mRNA expression in human fibroblasts. Role of activator protein-1.
Interleukin 1beta enhances invasive ability of gastric carcinoma through nuclear factor-kappaB activation.
Interleukin-1 alpha promotes tumor growth and cachexia in MCF-7 xenograft model of breast cancer.
Interleukin-11 induces the expression of matrix metalloproteinase 13 in gastric cancer SCH cells partly via the PI3K-AKT and JAK-STAT3 pathways.
Interleukin-17 potently increases non-small cell lung cancer growth.
Interleukin-18 among atrial fibrillation patients in the absence of structural heart disease.
Interleukin-1beta and tumor necrosis factor-alpha decrease collagen synthesis and increase matrix metalloproteinase activity in cardiac fibroblasts in vitro.
Interleukin-1beta and tumor necrosis factor-alpha induce chemokine and matrix metalloproteinase gene expression in human colonic subepithelial myofibroblasts.
Interleukin-1beta induced activation of nuclear factor-kappab can be inhibited by novel pharmacological agents in osteoarthritis.
Interleukin-32 stimulates osteosarcoma cell invasion and motility via AKT pathway-mediated MMP-13 expression.
Interleukin-8 synthesis and the onset of labor.
Interplay between epidermal growth factor receptor and Janus kinase 3 regulates polychlorinated biphenyl-induced matrix metalloproteinase-3 expression and transendothelial migration of tumor cells.
Interstitial Score and Concentrations of IL-4R?, PAR-2, and MMP-7 in Bronchoalveolar Lavage Fluid Could Be Useful Markers for Distinguishing Idiopathic Interstitial Pneumonias.
Intervention of human breast cell carcinogenesis chronically induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Intra-articular lentivirus-mediated insertion of the fat-1 gene ameliorates osteoarthritis.
Intracellular Acidosis Promotes Mitochondrial Apoptosis Pathway: Role of EMMPRIN Down-regulation via Specific Single-chain Fv Intrabody.
Intracellular matrix metalloproteinase-2 (MMP-2) regulates human platelet activation via hydrolysis of talin.
Involvement of histone deacetylation in ras-induced down-regulation of the metastasis suppressor RECK.
Involvement of inactive GSK3beta overexpression in tumorigenesis and progression of gastric carcinomas.
Involvement of matrix metalloproteinase activity in hormone-induced mammary tumor regression.
Involvement of plasmin-mediated extracellular activation of progalanin in angiogenesis.
Involvement of specific matrix metalloproteinases during tumor necrosis factor/IFNgamma-based cancer therapy in mice.
Involvement of the NF-kappa B/matrix metalloproteinase pathway in cardiac fibrosis of mice lacking guanylyl cyclase/natriuretic peptide receptor A.
Involvement of TNF-alpha in enhancement of invasion and metastasis of colon 26-L5 carcinoma cells in mice by social isolation stress.
Irradiation of normal mouse tissue increases the invasiveness of mammary cancer cells.
Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression.
Isolation and characterization of novel RECK tumor suppressor gene splice variants.
Isolation, characterization, and expression of feline stromelysin-1 in naturally developing tumors in cats.
Isoliquiritin Apioside Suppresses in vitro Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells.
Isoorientin induces apoptosis, decreases invasiveness, and downregulates VEGF secretion by activating AMPK signaling in pancreatic cancer cells.
Japan-China Joint Medical Workshop on Drug Discoveries and Therapeutics 2008: The need of Asian pharmaceutical researchers' cooperation.
JNP3, a new compound, suppresses PMA-induced tumor cell invasion via NF-?B down regulation in MCF-7 breast cancer cells.
Kaempferitrin inhibits proliferation, induces apoptosis, and ameliorates inflammation in human rheumatoid arthritis fibroblast-like synoviocytes.
Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKC{delta}-mediated signaling in MCF-7 human breast cancer cells.
KB-R7785, a novel matrix metalloproteinase inhibitor, exerts its antidiabetic effect by inhibiting tumor necrosis factor-alpha production.
Keratoconus: an inflammatory disorder?
Key roles for GRB2-associated-binding protein 1, phosphatidylinositol-3-kinase, cyclooxygenase 2, prostaglandin E2 and transforming growth factor alpha in linoleic acid-induced upregulation of lung and breast cancer cell growth.
KI-67 AND hTERT expression can aid in the distinction between malignant and benign pheochromocytoma and paraganglioma.
Knockdown of EMMPRIN (OX47) in MRMT-1 Carcinoma Cells Inhibits Tumor Growth and Decreases Cancer-induced Bone Destruction and Pain.
Knockdown of Matrix Metallopeptidase 9 Inhibits Metastasis of Oral Squamous Cell Carcinoma Cells in a Zebrafish Xenograft Model.
Knockout of MMP3 Weakens Solid Tumor Organoids and Cancer Extracellular Vesicles.
KSHV activation of VEGF secretion and invasion for endothelial cells is mediated through viral upregulation of emmprin-induced signal transduction.
LABAZ1: A metastatic tumor model for renal cell carcinoma expressing the carbonic anhydrase type 9 tumor antigen.
Latanoprost-induced changes in rat intraocular pressure: direct or indirect?
Lentivirus mediated RNA interference of EMMPRIN (CD147) gene inhibits the proliferation, matrigel invasion and tumor formation of breast cancer cells.
Lentivirus-induced knockdown of LRP1 induces osteoarthritic-like effects and increases susceptibility to apoptosis in chondrocytes via the nuclear factor-?B pathway.
Let-7b-mediated suppression of basigin expression and metastasis in mouse melanoma cells.
Likelihood ratios for the prediction of preterm delivery with biomarkers.
LncRNA DANCR promotes the proliferation, migration, and invasion of tongue squamous cell carcinoma cells through miR-135a-5p/KLF8 axis.
LncRNA ODRUL Contributes to Osteosarcoma Progression through the miR-3182/MMP2 Axis.
Local activity of matrix metalloproteinases in a case of botryoid sarcoma.
Localization of a mutant p53 response element on the tissue inhibitor of metalloproteinase-3 promoter: mutant p53 activities are distinct from wild-type.
Localization of mRNAs representing collagenase and TIMP in sections of healing human burn wounds.
Localized Affinity-Based Delivery of Prinomastat for Cancer Treatment.
Long Non-Coding RNA HOXA-AS2 Regulates Malignant Glioma Behaviors and Vasculogenic Mimicry Formation via the MiR-373/EGFR Axis.
Long non-coding RNA SNHG5 affects the invasion and apoptosis of renal cell carcinoma by regulating the miR-363-3p-Twist1 interaction.
Long-term effects of silver nanoparticles in caco-2 cells.
Lonidamine causes inhibition of angiogenesis-related endothelial cell functions.
Loss of BRCA2 promotes prostate cancer cell invasion through up-regulation of matrix metalloproteinase-9.
Loss of collagenase-2 confers increased skin tumor susceptibility to male mice.
Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function.
Low density lipoprotein receptor-related protein mediates endocytic clearance of pro-MMP-2.TIMP-2 complex through a thrombospondin-independent mechanism.
Low expression of reversion-inducing cysteine-rich protein with Kazal motifs (RECK) indicates a shorter survival after resection in patients with adenocarcinoma of the lung.
Low molecular weight fucoidan attenuates experimental abdominal aortic aneurysm through interfering the leukocyte-endothelial cells interaction.
Luteolin inhibits IL-1?-induced in?ammation in rat chondrocytes and attenuates osteoarthritis progression in a rat model.
Luteolin-7-O-Glucoside Inhibits Oral Cancer Cell Migration and Invasion by Regulating Matrix Metalloproteinase-2 Expression and Extracellular Signal-Regulated Kinase Pathway.
Lycopene inhibits experimental metastasis of human hepatoma SK-Hep-1 cells in athymic nude mice.
Lycopene inhibits matrix metalloproteinase-9 expression and down-regulates the binding activity of nuclear factor-kappa B and stimulatory protein-1.
Macrophage ABHD5 suppresses NF-?B-dependent matrix metalloproteinase expression and cancer metastasis.
Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2/anti-CD40 immunotherapy.
Macrophages Polarized by Expression of ToxoGRA15II Inhibit Growth of Hepatic Carcinoma.
Macrophages regulate tumor necrosis factor-alpha expression in adipocytes through the secretion of matrix metalloproteinase-3.
Macrophages stimulate gastric and colorectal cancer invasion through EGFR Y(1086), c-Src, Erk1/2 and Akt phosphorylation and smallGTPase activity.
Macroscopic portal vein tumor thrombi of liver metastasis from colorectal cancer.
Major surface protein complex of Treponema denticola induces the production of tumor necrosis factor alpha, interleukin-1beta, interleukin-6 and matrix metalloproteinase 9 by primary human peripheral blood monocytes.
MALDI-TOF MS characterization of proanthocyanidins from cranberry fruit (Vaccinium macrocarpon) that inhibit tumor cell growth and matrix metalloproteinase expression in vitro
Management of cardiac fibrosis in diabetic rats; the role of peroxisome proliferator activated receptor gamma (PPAR-gamma) and calcium channel blockers (CCBs).
Mangiferin: a natural miracle bioactive compound against lifestyle related disorders.
Mapping of the metalloproteinase gene matrilysin (MMP7) to human chromosome 11q21-->q22.
Marimastat as maintenance therapy for patients with advanced gastric cancer: a randomised trial.
Marked inhibition of tumor growth in a malignant glioma tumor model by a novel synthetic matrix metalloproteinase inhibitor AG3340.
Markers of squamocolumnar junction cells in normal tonsils and oropharyngeal cancer with and without HPV infection.
Mast cell activation and its relation to proinflammatory cytokine production in the rheumatoid lesion.
Mast cell infiltration in acute coronary syndromes: implications for plaque rupture.
Matrilysin (matrix metalloproteinase-7) selects for apoptosis-resistant mammary cells in vivo.
Matrilysin in early stage intestinal tumorigenesis.
Matrilysin [MMP-7] expression selects for cells with reduced sensitivity to apoptosis.
Matrilysin-2, a new matrix metalloproteinase expressed in human tumors and showing the minimal domain organization required for secretion, latency, and activity.
Matrilysin-specific antisense oligonucleotide inhibits liver metastasis of human colon cancer cells in a nude mouse model.
Matrix architecture dictates three-dimensional migration modes of human macrophages: differential involvement of proteases and podosome-like structures.
Matrix metalloproteinase (MMP)-1, -9 and -13 as prognostic factors in salivary gland cancer.
Matrix metalloproteinase (MMP)-2 and MMP-9 Expression in Tumor Infiltrating CD3 Lymphocytes From Women With Endometrial Cancer.
Matrix metalloproteinase (MMP)-7 in salivary gland cancer.
Matrix metalloproteinase (MMP)-9 in cancer-associated fibroblasts (CAFs) is suppressed by omega-3 polyunsaturated fatty acids in vitro and in vivo.
Matrix metalloproteinase (MMP-2 and MMP-9) and steroid receptor expressions in feline mammary tumors.
Matrix metalloproteinase 13 is induced in fibroblasts in polyomavirus middle T antigen-driven mammary carcinoma without influencing tumor progression.
Matrix metalloproteinase 2 and 9 expression correlated with cavernous sinus invasion of pituitary adenomas.
Matrix metalloproteinase 3 is present in the cell nucleus and is involved in apoptosis.
Matrix metalloproteinase 7 and perlecan in oral epithelial dysplasia and carcinoma in situ: an aid for histopathologic recognition of their cell proliferation centers.
Matrix metalloproteinase 9 expression and prognosis in colorectal cancer: a meta-analysis.
Matrix metalloproteinase 9 inhibits the motility of highly aggressive HSC-3 oral squamous cell carcinoma cells.
Matrix metalloproteinase 9 is induced by the Epstein-Barr virus BZLF1 transactivator.
Matrix metalloproteinase 9-mediated shedding of syndecan 4 in response to tumor necrosis factor ?: a contributor to endothelial cell glycocalyx dysfunction.
Matrix metalloproteinase activity and osteoclasts in experimental prostate cancer bone metastasis tissue.
Matrix Metalloproteinase Activity in the Stromal Cell of Giant Cell Tumor of Bone.
Matrix metalloproteinase activity in tumor, stromal tissue, and serum from cats with malignancies.
Matrix metalloproteinase activity modulates tumor size, cell motility, and cell invasiveness in murine aggressive fibromatosis.
Matrix metalloproteinase activity, bone matrix turnover, and tumor cell proliferation in prostate cancer bone metastasis.
Matrix metalloproteinase and G protein coupled receptors: Co-conspirators in the pathogenesis of autoimmune disease and cancer.
Matrix Metalloproteinase Cleavable Nanoparticles for Tumor Microenvironment and Tumor Cell Dual-Targeting Drug Delivery.
Matrix metalloproteinase contribution in management of cancer proliferation, metastasis and drug targeting.
Matrix metalloproteinase digestion of aggrecan in human cartilage tumours.
Matrix metalloproteinase expression during experimental autoimmune encephalomyelitis and effects of a combined matrix metalloproteinase and tumour necrosis factor-alpha inhibitor.
Matrix metalloproteinase expression in high grade soft tissue sarcomas.
Matrix metalloproteinase expression in normal skin associated with basal cell carcinoma and in distal skin from the same patients.
Matrix metalloproteinase expression is related to angiogenesis and histologic grade in spindle cell soft tissue neoplasms of the extremities.
Matrix metalloproteinase gene polymorphisms and oral cancer.
Matrix metalloproteinase induction in the tumor stroma does not depend on CD147 expression in murine B16 melanoma.
Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice.
Matrix metalloproteinase inhibitor COL-3 in the treatment of AIDS-related Kaposi's sarcoma: a phase I AIDS malignancy consortium study.
Matrix metalloproteinase inhibitor RECK expression in canine tumors.
Matrix metalloproteinase inhibitor Ro 28-2653 in combination with estramustine: tumor-reducing effects on hormone-sensitive prostate cancer in rats.
Matrix metalloproteinase inhibitors and cancer: trials and tribulations.
Matrix metalloproteinase inhibitors for cancer therapy:the current situation and future prospects.
Matrix Metalloproteinase Inhibitors in Cancer Therapy: Turning Past Failures Into Future Successes.
Matrix metalloproteinase inhibitors in cancer: an update.
Matrix metalloproteinase inhibitors in the treatment of cancer.
Matrix metalloproteinase inhibitors--an emphasis on gastrointestinal malignancies.
Matrix metalloproteinase inhibitors: a novel class of anticancer agents.
Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses.
Matrix metalloproteinase MMP9 maintains epithelial barrier function and preserves mucosal lining in colitis associated cancer.
Matrix metalloproteinase production by cultured human endometrial stromal cells: identification of interstitial collagenase, gelatinase-A, gelatinase-B, and stromelysin-1 and their differential regulation by interleukin-1 alpha and tumor necrosis factor-alpha.
Matrix Metalloproteinase Sensitive Gold Nanorod for Simultaneous Bioimaging and Photothermal Therapy of Cancer.
Matrix metalloproteinase triggered size-shrinkable gelatin-gold fabricated nanoparticles for tumor microenvironment sensitive penetration and diagnosis of glioma.
Matrix metalloproteinase type 2 expression in malignant adrenocortical tumors: Diagnostic and prognostic significance in a series of 50 adrenocortical carcinomas.
Matrix metalloproteinase-1 and cytokines in patients with acute pancreatitis.
Matrix metalloproteinase-1 is a crucial bone metastasis factor in a human breast cancer-derived highly invasive cell line.
Matrix metalloproteinase-13 is a target gene of high-mobility group box-containing protein 1 in modulating oral cancer cell invasion.
Matrix metalloproteinase-2 and -9 and tissue inhibitor of metalloproteinase-1 and -2 in sera and urine of patients with renal carcinoma.
Matrix metalloproteinase-2 and -9 expression in astrocytic tumors.
Matrix metalloproteinase-2 and -9 secreted by leukemic cells increase the permeability of blood-brain barrier by disrupting tight junction proteins.
Matrix metalloproteinase-2 status in stromal fibroblasts, not in tumor cells, is a significant prognostic factor in non-small-cell lung cancer.
Matrix metalloproteinase-2-targeted superparamagnetic Fe3O4-PEG-G5-MMP2@Ce6 nanoprobes for dual-mode imaging and photodynamic therapy.
Matrix metalloproteinase-3 secretion from human colonic subepithelial myofibroblasts: role of interleukin-17.
Matrix metalloproteinase-7, -8, -9, -15, and -25 in minor salivary gland adenoid cystic carcinoma.
Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion.
Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells. Regulation by tumor necrosis factor-alpha and doxycycline.
Matrix metalloproteinase-8 promoter gene polymorphisms in Mexican women with ovarian cancer.
Matrix metalloproteinase-8: cleavage can be decisive.
Matrix metalloproteinase-9 expression in mammary gland tumors in dogs and its relationship with prognostic factors and patient outcome.
Matrix metalloproteinase-9 overexpression is closely related to poor prognosis in patients with colon cancer.
Matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 and tumour necrosis factor alpha release during cardiopulmonary bypass.
Matrix metalloproteinase-dependent microsomal prostaglandin E synthase-1 expression in macrophages: role of TNF-? and the EP4 prostanoid receptor.
Matrix metalloproteinase-mediation of tumor targeting human recombinant tumor necrosis factor-? fusion protein.
Matrix metalloproteinases 21 and 26 are differentially expressed in esophageal squamous cell cancer.
Matrix metalloproteinases and inhibitors in dentistry.
Matrix metalloproteinases and matrix metalloproteinase inhibitors in lung cancer.
Matrix metalloproteinases and metastatic cancer.
Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases Are Essential for the Inflammatory Response in Cancer Cells.
Matrix metalloproteinases and tumor invasion: from correlation and causality to the clinic.
Matrix metalloproteinases as breast cancer drivers and therapeutic targets.
Matrix metalloproteinases contribute to brain damage in experimental pneumococcal meningitis.
Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies.
Matrix metalloproteinases in human melanoma cell lines and xenografts: increased expression of activated matrix metalloproteinase-2 (MMP-2) correlates with melanoma progression.
Matrix metalloproteinases in human melanoma.
Matrix metalloproteinases of vascular wall cells are increased in balloon-injured rat carotid artery.
Matrix metalloproteinases, angiogenesis, and cancer: commentary re: A. C. Lockhart et al., Reduction of wound angiogenesis in patients treated with BMS-275291, a broad spectrum matrix metalloproteinase inhibitor. Clin. Cancer Res., 9: 00-00, 2003.
Matrix metalloproteinases, tissue inhibitors of matrix metalloproteinases and angiogenic cytokines in peripheral blood of patients with thyroid cancer.
Matrix metalloproteinases-1 and -8 improve the distribution and efficacy of an oncolytic virus.
Matrix metalloproteinases-2/9-sensitive peptide-conjugated polymer micelles for site-specific release of drugs and enhancing tumor accumulation: preparation and in vitro and in vivo evaluation.
Matrix metalloproteinases-7, -8, -9 and TIMP-1 in the follow-up of diisocyanate-induced asthma.
Matrix metalloproteinases: new directions toward inhibition in the fight against cancers.
Matrix metalloproteinases: roles in cancer and metastasis.
Matrix-directed regulation of pericellular proteolysis and tumor progression.
MBP-1 inhibits breast cancer growth and metastasis in immunocompetent mice.
Mechanical impact induces cartilage degradation via mitogen activated protein kinases.
Mechanisms of KE298, 2-acetylthiomethyl-3-(4-methylbenzoyl) propionic acid, to suppress abnormal synovial cell functions in patients with rheumatoid arthritis.
Mechanisms of matrix metalloproteinase-9 upregulation and tissue destruction in various organs in influenza A virus infection.
Mechanistic Insights into Side Effects of Troglitazone and Rosiglitazone Using a Novel Inverse Molecular Docking Protocol.
Mechanistic investigations of matrix metalloproteinase-8 inhibition by metal abstraction peptide.
Mediators of glioblastoma resistance and invasion during antivascular endothelial growth factor therapy.
Medical treatment of endometriosis.
Melanoma-mediated dissolution of extracellular matrix: contribution of urokinase-dependent and metalloproteinase-dependent proteolytic pathways.
Melatonin improves periodontitis-induced kidney damages by decreasing inflammatory stress and apoptosis in rats.
Membrane type (MT) 1-matrix metalloproteinase (MMP) and MMP-2 expression in ligature-induced periodontitis in the rat.
Membrane type 1 matrix metalloproteinase (MT1-MMP/MMP-14) cleaves and releases a 22-kDa extracellular matrix metalloproteinase inducer (EMMPRIN) fragment from tumor cells.
Membrane type 1 matrix metalloproteinase regulates cellular invasiveness and survival in cutaneous epidermal cells.
Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-alpha convertase activity but does not activate pro-MMP2.
Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix.
Membrane-type matrix metalloproteinase-1(MT1-MTP) gene is overexpressed in highly invasive hepatocellular carcinomas.
Membrane-type-1 matrix metalloproteinase, matrix metalloproteinase 2, and tissue inhibitor of matrix proteinase 2 in prostate cancer: identification of patients with poor prognosis by immunohistochemistry.
Mesothelin overexpression promotes mesothelioma cell invasion and MMP-9 secretion in an orthotopic mouse model and in epithelioid pleural mesothelioma patients.
Met inactivation by S-allylcysteine suppresses the migration and invasion of nasopharyngeal cancer cells induced by hepatocyte growth factor.
Metalloproteinases and their roles in human cancer.
Metalloproteinases and tumor necrosis factor-alpha activities in synovial fluids of horses: correlation with articular cartilage alterations.
Metalloproteinases in Ovarian Cancer.
Metastatic ability of MXT mouse mammary subpopulations correlates with clonal expression and/or membrane-association of gelatinase A.
Methylarsonous acid causes oxidative DNA damage in cells independent of the ability to biomethylate inorganic arsenic.
Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers.
Methylsulfonylmethane is effective against gastric mucosal injury.
Microarray-based transcriptional and epigenetic profiling of matrix metalloproteinases, collagens and related genes in cancer.
Micronutrient synergy--a new tool in effective control of metastasis and other key mechanisms of cancer.
MicroRNA let-7i-3p affects osteoblast differentiation in ankylosing spondylitis via targeting PDK1.
MicroRNA-155-5p inhibits the invasion and migration of prostate cancer cells by targeting SPOCK1.
microRNA-9 targets matrix metalloproteinase 14 to inhibit invasion, metastasis, and angiogenesis of neuroblastoma cells.
MicroRNA?15a?5p induces pulmonary artery smooth muscle cell apoptosis in a pulmonary arterial hypertension model via the VEGF/p38/MMP?2 signaling pathway.
Mid-trimester amniotic fluid pro-inflammatory biomarkers predict the risk of spontaneous preterm delivery in twins: a retrospective cohort study.
Minimally invasive colorectal resection is associated with significantly elevated levels of plasma matrix metalloproteinase 3 (MMP-3) during the first month after surgery which may promote the growth of residual metastases.
Minocycline impedes African trypanosome invasion of the brain in a murine model.
miR-1307-5p regulates proliferation and apoptosis of chondrocytes in osteoarthritis by specifically inhibiting transforming growth factor beta-induced gene.
miR-181a-5p Inhibits Cancer Cell Migration and Angiogenesis via Downregulation of Matrix Metalloproteinase-14.
miR-195 suppresses abdominal aortic aneurysm through the TNF-?/NF-?B and VEGF/PI3K/Akt pathway.
MiR-26b Mimic Inhibits Glioma Proliferation In Vitro and In Vivo Suppressing COX-2 Expression.
miR-410-3p Suppresses Cytokine Release from Fibroblast-Like Synoviocytes by Regulating NF-?B Signaling in Rheumatoid Arthritis.
Missing the target: matrix metalloproteinase antitargets in inflammation and cancer.
Mithramycin downregulates proinflammatory cytokine-induced matrix metalloproteinase gene expression in articular chondrocytes.
Mitochondrial-Targeting Antioxidant SS-31 Suppresses Airway Inflammation and Oxidative Stress Induced by Cigarette Smoke.
Mitogen-activated protein kinase (MAPK) regulates the expression of progelatinase B (MMP-9) in breast epithelial cells.
MMI-166, a selective matrix metalloproteinase inhibitor, promotes apoptosis in human pancreatic cancer.
MMP-10 is overexpressed, proteolytically active, and a potential target for therapeutic intervention in human lung carcinomas.
MMP-11 as a biomarker for metastatic breast cancer by immunohistochemical-assisted imaging mass spectrometry.
MMP-2 activation and stepwise progression of pulmonary adenocarcinoma: analysis of MMP-2 and MMP-9 with gelatin zymography.
MMP-2 release and activation in ovarian carcinoma: the role of fibroblasts.
MMP-2, TNF-? and NLRP1 polymorphisms in Chinese patients with ankylosing spondylitis and rheumatoid arthritis.
MMP-2/TIMP-2/TIMP-4 versus MMP-9/TIMP-3 in transition from compensatory hypertrophy and angiogenesis to decompensatory heart failure.
MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors.
MMP-7 (-181A>G) promoter polymorphisms and risk for cervical cancer.
MMP-8 C-799?T, Lys460Thr, and Lys87Glu variants are not related to risk of cancer.
MMP-9 mRNA as a therapeutic marker in acute and chronic stages of arthritis induced by type II collagen antibody.
MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis.
MMP13 is a potential prognostic marker for colorectal cancer.
MMP16 promotes tumor metastasis and indicates poor prognosis in hepatocellular carcinoma.
MMP9 polymorphisms and breast cancer risk: a report from the Shanghai Breast Cancer Genetics Study.
Modulation of matrix metalloproteinase-9 secretion from tumor-associated macrophage-like cells by proteolytically processed laminin-332 (laminin-5).
Modulation of MMP-2 and -9 secretion by cytokines, inducers and inhibitors in human melanoma A-2058 cells.
Modulation of MMP-2 and MMP-9 secretion by cytokines, inducers and inhibitors in human glioblastoma T-98G cells.
Modulation of u-PA, MMPs and their inhibitors by a novel nutrient mixture in adult human sarcoma cell lines.
Modulation of u-PA, MMPs and their inhibitors by a novel nutrient mixture in human lung cancer and mesothelioma cell lines.
Modulation of u-PA, MMPs and their inhibitors by a novel nutrient mixture in pediatric human sarcoma cell lines.
Modulation of uPA, MMPs and their inhibitors by a novel nutrient mixture in human colorectal, pancreatic and hepatic carcinoma cell lines.
Modulation of uPA, MMPs and their inhibitors by a novel nutrient mixture in human glioblastoma cell lines.
Molecular docking and inhibition of matrix metalloproteinase-2 by novel difluorinatedbenzylidene curcumin analog.
Molecular Link Mechanisms between Inflammation and Cancer.
Molecular mechanism of force induced stabilization of collagen against enzymatic breakdown.
Molecular mechanism of transcriptional activation of human gelatinase B by proximal promoter.
Molecular mechanisms of anticancer activity of deoxyelephantopin in cancer cells.
Molecular mechanisms of therapeutic hypothermia on neurological function in a swine model of cardiopulmonary resuscitation.
Molecular profiling of angiogenesis with targeted ultrasound imaging: early assessment of antiangiogenic therapy effects.
Molecular prognosticators of complex karyotype soft tissue sarcoma outcome: a tissue microarray-based study.
Molecularly engineered PEG hydrogels: a novel model system for proteolytically mediated cell migration.
Monascus purpureus-fermented rice inhibits tumor necrosis factor-?-induced upregulation of matrix metalloproteinase 2 and 9 in human aortic smooth muscle cells.
Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231.
Monoclonal anti?MUC1 antibody with novel octahydropyrazino[2,1?a:5,4?a']diisoquinoline derivative as a potential multi?targeted strategy in MCF?7 breast cancer cells.
Mouse keratinocytes immortalized with large T antigen acquire alpha3beta1 integrin-dependent secretion of MMP-9/gelatinase B.
MT-LOOP-dependent localization of membrane type I matrix metalloproteinase (MT1-MMP) to the cell adhesion complexes promotes cancer cell invasion.
MT1-MMP modulates melanoma cell dissemination and metastasis through activation of MMP2 and RAC1.
MT1-mmp: a collagenase essential for tumor cell invasive growth.
MT1G is Silenced by DNA Methylation and Contributes to the Pathogenesis of Hepatocellular Carcinoma.
MUC1 protein induces urokinase-type plasminogen activator (uPA) by forming a complex with NF-?B p65 transcription factor and binding to the uPA promoter, leading to enhanced invasiveness of cancer cells.
Multi-analyte profiling in human carotid atherosclerosis uncovers pro-inflammatory macrophage programming in plaques.
Multidrug-Resistant Pseudomonas aeruginosa Evokes Differential Inflammatory Responses in Human Microglial and Retinal Pigment Epithelial Cells.
Multifunctional Mesoporous Silica Nanoparticles with Thermal-Responsive Gatekeeper for NIR Light-Triggered Chemo/Photothermal-Therapy.
Multiplex Cytokine Profiling Identifies Interleukin-27 as a Novel Biomarker for Neonatal Early Onset Sepsis.
Mutational analysis of the GNA11, MMP27, FGD1, TRRAP and GRM3 genes in thyroid cancer.
Mutations in two matrix metalloproteinase genes, MMP-2 and MT1-MMP, are synthetic lethal in mice.
Mycobacterium indicus pranii (Mw) inhibits invasion by reducing matrix metalloproteinase (MMP-9) via AKT/ERK-1/2 and PKC? signalling: a potential candidate in melanoma cancer therapy.
Myeloperoxidase is increased in human cerebral aneurysms and increases formation and rupture of cerebral aneurysms in mice.
N-cadherin haploinsufficiency increases survival in a mouse model of pancreatic cancer.
Nafamostat Mesilate Enhances the Radiosensitivity and Reduces the Radiation-Induced Invasive Ability of Colorectal Cancer Cells.
NanoVelcro-captured CTC number concomitant with enhanced serum levels of MMP7 and MMP9 enables accurate prediction of metastasis and poor prognosis in patients with lung adenocarcinoma.
Natural history of markers of collagen turnover in patients with early diastolic dysfunction and impact of eplerenone.
Near-infrared optical proteolytic beacons for in vivo imaging of matrix metalloproteinase activity.
NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis.
Neoadjuvant radiochemotherapy increases matrix metalloproteinase activity in healthy tissue in esophageal cancer patients.
Neuroendocrine Modulation of Signal Transducer and Activator of Transcription-3 in Ovarian Cancer.
Neuroinflammation Induces Neurodegeneration.
Neurotransmitter Substance P Mediates Pancreatic Cancer Perineural Invasion via NK-1R in Cancer Cells.
Neutrophil Gelatinase-Associated Lipocalin (NGAL), Pro-Matrix Metalloproteinase-9 (pro-MMP-9) and Their Complex Pro-MMP-9/NGAL in Leukaemias.
New approaches to selectively target cancer-associated matrix metalloproteinase activity.
New HIV-drug inhibits in vitro bladder cancer migration and invasion.
New hope for matrix metalloproteinase inhibitors in cancer therapy.
New medical treatments for endometriosis.
New radioiodinated carboxylic and hydroxamic matrix metalloproteinase inhibitor tracers as potential tumor imaging agents.
Nifuroxazide induces apoptosis and impairs pulmonary metastasis in breast cancer model.
Nitric Oxide Synthase-2-Derived Nitric Oxide Drives Multiple Pathways of Breast Cancer Progression.
Non-small cell lung cancer invasion and metastasis promoted by MMP-26.
Noncanonical Activation of Notch1 Protein by Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Controls Melanoma Cell Proliferation.
Nonselective matrix metalloproteinase but not tumor necrosis factor-? inhibition effectively preserves the early critical colon anastomotic integrity.
Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells.
Novel 3-galloylamido-N'-substituted-2,6-piperidinedione-N-acetamide peptidomimetics as metalloproteinase inhibitors.
Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: complete regression of hepatoma growth and metastasis by dual mechanism.
Novel approach to analysis of in vitro tumor angiogenesis with a variable-pressure scanning electron microscope: suppression by matrix metalloproteinase inhibitor SI-27.
Novel approaches to target pancreatic cancer.
Novel inhibitors of urokinase-type plasminogen activator and matrix metalloproteinase expression in metastatic cancer cell lines.
Novel matrix metalloproteinase inhibitor [18F]marimastat-aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer.
Novel matrix metalloproteinase inhibitors: an updated patent review (2014 - 2020).
Novel Potent Proline-Based Metalloproteinase Inhibitors: Design, (Radio)Synthesis, and First in Vivo Evaluation as Radiotracers for Positron Emission Tomography.
Novel retinoic acid derivative ABPN has potent inhibitory activity on cell growth and apoptosis in cancer cells.
Nrf2-peroxiredoxin I axis in polymorphous adenocarcinoma is associated with low matrix metalloproteinase 2 level.
O-glycan analysis of natural human neutrophil gelatinase B using a combination of normal phase-HPLC and online tandem mass spectrometry: implications for the domain organization of the enzyme.
Obesity-associated Adipose Stromal Cells Promote Breast Cancer Invasion Through Direct Cell Contact and ECM Remodeling.
Oleuropein induces anti-metastatic effects in breast cancer.
Olfactomedin 4 suppresses tumor growth and metastasis of mouse melanoma cells through downregulation of integrin and MMP genes.
Oncostatin M in combination with tumor necrosis factor alpha induces cartilage damage and matrix metalloproteinase expression in vitro and in vivo.
Optical imaging of cancer-related proteases using near-infrared fluorescence matrix metalloproteinase-sensitive and cathepsin B-sensitive probes.
Optical proteolytic beacons for in vivo detection of matrix metalloproteinase activity.
Oral and ocular administration of crocetin prevents retinal edema in a murine retinal vein occlusion model.
Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo.
Orally active MMP-1 sparing ?-tetrahydropyranyl and ?-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease.
Organelle Specific O-Glycosylation Drives MMP14 Activation, Tumor Growth, and Metastasis.
Osteoactivin Regulates Head and Neck Squamous Cell Carcinoma Invasion by Modulating Matrix Metalloproteases.
Osthole inhibits the invasive ability of human lung adenocarcinoma cells via suppression of NF-?B-mediated matrix metalloproteinase-9 expression.
Ovariectomy Exacerbates Apical Periodontitis in Rats with an Increase in Expression of Proinflammatory Cytokines and Matrix Metalloproteinases.
Overexpression of B7-H4 promotes renal cell carcinoma progression by recruiting tumor-associated neutrophils via upregulation of CXCL8.
Overexpression of CD147 in ovarian cancer is initiated by the hypoxic microenvironment.
Overexpression of collagenase 1 (MMP-1) is mediated by the ERK pathway in invasive melanoma cells: role of BRAF mutation and fibroblast growth factor signaling.
Overexpression of EMMPRIN Isoform 2 Is Associated with Head and Neck Cancer Metastasis.
Overexpression of EphA2, MMP-9, and MVD-CD34 in hepatocellular carcinoma: Implications for tumor progression and prognosis.
Overexpression of extracellular matrix metalloproteinase inducer in multidrug resistant cancer cells.
Overexpression of membrane-type 2 matrix metalloproteinase induced by hypoxia-inducible factor-1? in pancreatic cancer: Implications for tumor progression and prognosis.
Overexpression of MMP21 and MMP28 is associated with gastric cancer progression and poor prognosis.
Overexpression of REIC/Dkk-3 suppresses the expression of CD147 and inhibits the proliferation of human bladder cancer cells.
Overexpression of SMYD3 and matrix metalloproteinase-9 are associated with poor prognosis of patients with gastric cancer.
Overexpression of tissue inhibitors of metalloproteinase 2 up-regulates NF-kappaB activity in melanoma cells.
Overexpression of twist and matrix metalloproteinase-9 with metastasis and prognosis in gastric cancer.
Overweight, hypertension and renal dysfunction in adulthood of neonatally overfed rats.
Oxidized LDL inhibit hepatocyte growth factor synthesis in coronary smooth muscle cells.
Palmatine inhibits TRIF-dependent NF-?B pathway against inflammation induced by LPS in goat endometrial epithelial cells.
Pancreatic cancer associated with obesity and diabetes: an alternative approach for its targeting.
Pancreatic stellate cells are an important source of MMP-2 in human pancreatic cancer and accelerate tumor progression in a murine xenograft model and CAM assay.
Pancreatic stellate cells-role in pancreas cancer.
Parallel in vivo and in vitro selection using phage display identifies protease-dependent tumor-targeting peptides.
Parthenolide inhibits pro-inflammatory cytokine production and exhibits protective effects on progression of collagen-induced arthritis in a rat model.
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Patients with hepatic breast cancer metastases demonstrate highly specific profiles of matrix metalloproteinases MMP-2 and MMP-9 after SIRT treatment as compared to other primary and secondary liver tumours.
PD-1 Blockade for Improving the Antitumor Efficiency of Polymer-Doxorubicin Nanoprodrug.
PEA3 is necessary for optimal epidermal growth factor receptor-stimulated matrix metalloproteinase expression and invasion of ovarian tumor cells.
Pediatric adrenocortical tumors: morphological diagnostic criteria and immunohistochemical expression of matrix metalloproteinase type 2 and human leucocyte-associated antigen (HLA) class II antigens Results from the Italian Pediatric Rare Tumor (TREP) Study project.
Peptidoglycan from sterile human spleen induces T-cell proliferation and inflammatory mediators in rheumatoid arthritis patients and healthy subjects.
Peptidomic analysis of pilose antler and its inhibitory effect on triple-negative breast cancer at multiple sites.
Perinatal Ureaplasma Exposure Is Associated With Increased Risk of Late Onset Sepsis and Imbalanced Inflammation in Preterm Infants and May Add to Lung Injury.
Periodontal treatment down-regulates protease-activated receptor-2 in human gingival crevicular fluid cells.
Periodontitis and Endothelial Dysfunction: Periodontal Clinical Parameters and Levels of Salivary Markers Interleukin-1?, Tumor Necrosis Factor-?, Matrix Metalloproteinase-2, Tissue Inhibitor of Metalloproteinases-2 Complex, and Nitric Oxide.
Periodontitis exacerbates the renal degenerative effects of obesity in rats.
Perspectives on the value of biomarkers in acute cardiac care and implications for strategic management.
Pharmacodynamic considerations in the use of matrix metalloproteinase inhibitors in cancer treatment.
Pharmacologic therapies in endometriosis: a systematic review.
Pharmacological inhibition of gelatinase B induction and tumor cell invasion.
Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding.
Phase I and pharmacologic study of the specific matrix metalloproteinase inhibitor BAY 12-9566 on a protracted oral daily dosing schedule in patients with solid malignancies.
Phase I and pharmacological study of the oral matrix metalloproteinase inhibitor, MMI270 (CGS27023A), in patients with advanced solid cancer.
Phase I clinical trial of oral COL-3, a matrix metalloproteinase inhibitor, in patients with refractory metastatic cancer.
Phase I trial of a novel matrix metalloproteinase inhibitor batimastat (BB-94) in patients with advanced cancer.
Phase I trial of the matrix metalloproteinase inhibitor BAY12-9566 in patients with advanced solid tumors.
Phase I/II trial of batimastat, a matrix metalloproteinase inhibitor, in patients with malignant ascites.
Phase II study of marimastat (BB-2516) in malignant melanoma: a clinical and tumor biopsy study of the National Cancer Institute of Canada Clinical Trials Group.
Phase II trial of temozolomide plus marimastat for recurrent anaplastic gliomas: A relationship among efficacy, joint toxicity and anticonvulsant status.
Phenotypes correlating to metastatic properties of pancreas adenocarcinoma in vivo: the importance of surface sialyl Lewis(a) antigen.
Phosphodiesterase 4 inhibitor cilomilast inhibits fibroblast-mediated collagen gel degradation induced by tumor necrosis factor-alpha and neutrophil elastase.
Phyllanthus spp. Exerts Anti-Angiogenic and Anti-Metastatic Effects Through Inhibition on Matrix Metalloproteinase Enzymes.
Piceatannol-3-O-?-D-glucopyranoside (PG) exhibits in vitro anti-metastatic and anti-angiogenic activities in HT1080 malignant fibrosarcoma cells.
Pigment epithelium-derived factor as a natural matrix metalloproteinase inhibitor: a comparison with classical matrix metalloproteinase inhibitors used for cancer treatment.
Piperine inhibit inflammation, alveolar bone loss and collagen fibers breakdown in a rat periodontitis model.
PKM2 enhances cancer invasion via ETS-1-dependent induction of matrix metalloproteinase in oral squamous cell carcinoma cells.
Placental growth factor promotes metastases of ovarian cancer through MiR-543-regulated MMP7.
Plasma concentration of tissue inhibitor of matrix metalloproteinase 1 in patients with colorectal carcinoma.
Plasma level of tissue inhibitor of matrix metalloproteinase-1 but not that of matrix metalloproteinase-8 predicts survival in head and neck squamous cell cancer.
Plasma Levels of Matrix Metalloproteinase (MMP)-2, MMP-9 and Tumor Necrosis Factor-? in Chronic Hepatitis C Virus Patients.
Plasma membrane-dependent activation of gelatinase A in human vascular endothelial cells.
Plasmatic level of neuroinflammatory markers predict the extent of diffusion-weighted image lesions in hyperacute stroke.
Plasminogen activator activities in short-term tissue cultures of benign prostatic hyperplasia and prostatic carcinoma.
Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis.
Pleiotropic effects of angiotensin II receptor blocker in hypertensive patients.
Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice.
Pleural biomarkers in diagnostics of malignant pleural effusion: a narrative review.
Pleural fluid tests to identify complicated parapneumonic effusions.
Pneumoperitoneum augmented tumor invasiveness is abolished by matrix metalloproteinase blockade.
Polymorphisms in the matrix metalloproteinase-1, 3, and 9 promoters and susceptibility to adult astrocytoma in northern China.
Polymorphisms in the promoter regions of matrix metalloproteinases 1 and 3 and cancer risk: a meta-analysis of 50 case-control studies.
Polymorphisms of matrix metalloproteinases 1, 2, 3 and 9 and susceptibility to lung, breast and colorectal cancer in over 30,000 subjects.
Polymorphisms of the matrix metalloproteinases associated with prostate cancer.
Possible correction of abnormal rheumatoid arthritis synovial cell function by jun D transfection in vitro.
Possible mechanisms of the crosstalk between Langerhans cells and regulatory T cells in extramammary Paget's disease by receptor activator of nuclear factor kappa-B ligand (RANKL)/ RANK pathways.
Possible role of matrix metalloproteinases (MMPs) in hyperostosis of intracranial meningiomas.
Potentiation of tumor cell invasion by co-culture with monocytes accompanying enhanced production of matrix metalloproteinase and fibronectin.
Preclinical and clinical studies of MMP inhibitors in cancer.
Preconditioning of Adipose-Derived Mesenchymal Stem-Like Cells with Eugenol Potentiates Their Migration and Proliferation In Vitro and Therapeutic Abilities in Rat Hepatic Fibrosis.
Predictive value of lymph node and tumor matrix metalloproteinase expression in the analysis of metastatic periampullary tumors.
Presence of active gelatinases in endometrial carcinoma and correlation of matrix metalloproteinase expression with increasing tumor grade and invasion.
Prevalence of vascular-endothelial growth factor, matrix metalloproteinases and tissue inhibitors of metalloproteinases in primary breast cancer.
Preventive and therapeutic effect of anti-IL-17 in an experimental model of elastase-induced lung injury in C57Bl6 mice.
Primary ductal adenocarcinoma of the lacrimal gland: case report.
Pro-addictive and anti-addictive factors for drug dependence.
Probes for non-invasive matrix metalloproteinase-targeted imaging with PET and SPECT.
Prodrug-Like, PEGylated Protein Toxin Trichosanthin for Reversal of Chemoresistance.
Profiling the evolution of human metastatic bladder cancer.
Progesterone-induced blocking factor differentially regulates trophoblast and tumor invasion by altering matrix metalloproteinase activity.
Prognostic Markers for Chorioamnionitis: IL-6, TNF-?, and MMP-8 in Vaginally Obtained Amniotic Fluid.
Prognostic Role of Matrix Metalloproteinases 2, 7, 8, 9 and Their Type 1 Tissue Inhibitor in Blood Serum of Patients with Kidney Cancer.
Prognostic significance of abnormal matrix collagen remodeling in colorectal cancer based on histologic and bioinformatics analysis.
Prognostic significance of matrix metalloproteinases type I expression and tumor front parameters in the presence of lymph node micrometastases in carcinoma of the larynx.
Prognostic significance of reversion-inducing cysteine-rich protein with Kazal motifs expression in resected pathologic stage IIIA N2 non-small-cell lung cancer.
Proinflammatory cytokines and lipopolysaccharides up regulate MMP-3 and MMP-13 production in Asian elephant (Elephas maximus) chondrocytes: attenuation by anti-arthritic agents.
Promoter polymorphisms in matrix metallopeptidase 1 and risk of cutaneous melanoma.
Prostaglandin E2 receptor EP1 phosphorylate CREB and mediates MMP2 expression in human cholangiocarcinoma cells.
Protease Nexin-1 affects the migration and invasion of C6 glioma cells through the regulation of urokinase Plasminogen Activator and Matrix Metalloproteinase-9/2.
Protease Responsive Nanogels for Transcytosis across the Blood-Brain Barrier and Intracellular Delivery of Radiopharmaceuticals to Brain Tumor Cells.
Proteases as drug targets.
Proteases in invasion: matrix metalloproteinases.
Protective effect of MAAs extracted from Porphyra tenera against UV irradiation-induced photoaging in mouse skin.
Protective effects of intratracheally administered quercetin on lipopolysaccharide-induced acute lung injury.
Protein expression of matrix metalloproteinase (MMP-1, -2, -3, -9 and -14) in Ewing family tumors and medulloblastomas of pediatric patients.
Proteolytic activity of human lymphoid tumor cells. Correlation with tumor progression.
Proteolytic mechanisms in the ovulatory folliculo-luteal transformation.
Proto-oncogene ACTR/AIB1 promotes cancer cell invasion by up-regulating specific matrix metalloproteinase expression.
Protocatechuic acid attenuates cerebral aneurysm formation and progression by inhibiting TNF-alpha/Nrf-2/NF-kB-mediated inflammatory mechanisms in experimental rats.
Pulmonary vascular destabilization in the premetastatic phase facilitates lung metastasis.
Purification of active matrix metalloproteinase catalytic domains and its use for screening of specific stromelysin-3 inhibitors.
PYGB siRNA inhibits the cell proliferation of human osteosarcoma cell lines.
Quantitative analysis of glioma cell invasion by confocal laser scanning microscopy in a novel brain slice model.
Quercetin prevent proteoglycan destruction by inhibits matrix metalloproteinase-9, matrix metalloproteinase-13, a disintegrin and metalloproteinase with thrombospondin motifs-5 expressions on osteoarthritis model rats.
Rac1 mediates type I collagen-dependent MMP-2 activation. role in cell invasion across collagen barrier.
Raf kinase inhibitor protein suppresses nuclear factor-?B-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression.
Randomized phase II feasibility study of combining the matrix metalloproteinase inhibitor BMS-275291 with paclitaxel plus carboplatin in advanced non-small cell lung cancer.
Randomized phase II trial of matrix metalloproteinase inhibitor COL-3 in AIDS-related Kaposi's sarcoma: an AIDS Malignancy Consortium Study.
Randomized phase III study of matrix metalloproteinase inhibitor BMS-275291 in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: National Cancer Institute of Canada-Clinical Trials Group Study BR.18.
Rap2a is a novel target gene of p53 and regulates cancer cell migration and invasion.
Rationally designed peptide-conjugated gold/platinum nanosystem with active tumor-targeting for enhancing tumor photothermal-immunotherapy.
Real-time quantitative PCR to detect changes in synovial gene expression in rheumatoid arthritis after corticosteroid treatment.
Recanalization of arterial thrombus, and inhibition with beta-radiation in a new murine carotid occlusion model: MRNA expression of angiopoietins, metalloproteinases, and their inhibitors.
Recent insights into natural product inhibitors of matrix metalloproteinases.
Recent opportunities in matrix metalloproteinase inhibitor drug design for cancer.
RECK impedes DNA repair by inhibiting the erbB/JAB1/Rad51 signaling axis and enhances chemosensitivity of breast cancer cells.
Recklessness as a hallmark of aggressive cancer.
Recombinant fimbriae protein of Porphyromonas gingivalis induces an inflammatory response via the TLR4/NF??B signaling pathway in human peripheral blood mononuclear cells.
Recombinant TIMP-1-GPI inhibits growth of fibrosarcoma and enhances tumor sensitivity to doxorubicin.
Recombinant viral protein promotes apoptosis and suppresses invasion of ovarian adenocarcinoma cells by targeting ?5?1 integrin to downregulate Akt and MMP-2.
Redirecting extracellular proteases to molecularly guide radiosensitizing drugs to tumors.
Redox state of adipose tissue for patients with gastric cancer and its connection with the body mass index and distance from the tumor.
Reduced levels of VEGF-A and MMP-2 and MMP-9 activity and increased TNF-alpha in menstrual endometrium and effluent in women with menorrhagia.
Reducing bleeding complications after thrombolytic therapy for stroke: clinical potential of metalloproteinase inhibitors and spin trap agents.
Reduction by dietary matrix metalloproteinase inhibitor BAY 12-9566N of neoplastic development induced by diethylnitrosamine, N-nitrosodimethylamine, or 7,12-dimethylbenz(a)anthracene in rats.
Reduction in glial immunity and neuropathology by a PAF antagonist and an MMP and TNFalpha inhibitor in SCID mice with HIV-1 encephalitis.
Reduction of alachlor-induced olfactory mucosal neoplasms by the matrix metalloproteinase inhibitor Ro 28-2653.
Reduction of hyaluronan-CD44-mediated growth, migration, and cisplatin resistance in head and neck cancer due to inhibition of Rho kinase and PI-3 kinase signaling.
Reduction of in vivo tumor growth by MMI-166, a selective matrix metalloproteinase inhibitor, through inhibition of tumor angiogenesis in squamous cell carcinoma cell lines of head and neck.
Reduction of Membrane Protein CRIM1 Decreases E-Cadherin and Increases Claudin-1 and MMPs, Enhancing the Migration and Invasion of Renal Carcinoma Cells.
Regorafenib diminishes the expression and secretion of angiogenesis and metastasis associated proteins and inhibits cell invasion via NF-?B inactivation in SK-Hep1 cells.
Regulation of apoptosis and inflammatory responses by IGFBP-3 in fibroblast-like synoviocytes and experimental animal models of rheumatoid arthritis.
Regulation of matrix metalloproteinase expression by tumor necrosis factor in a murine model of retinal neovascularization.
Regulation of matrix metalloproteinase expression in human vein and microvascular endothelial cells. Effects of tumour necrosis factor alpha, interleukin 1 and phorbol ester.
Regulation of matrix metalloproteinase expression in tumor invasion.
Regulation of matrix metalloproteinase production and tumor cell invasion by four monoclonal antibodies against different epitopes of HAb18G/CD147 extracellular domain.
Regulation of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in MCF-7 cells: comparison with regulatory mechanisms of pS2 expression.
Regulation of membrane-type 4 matrix metalloproteinase by SLUG contributes to hypoxia-mediated metastasis.
Regulation of metastasis-related gene expression by p53: a potential clinical implication.
Regulation of MMP-1 expression in response to hypoxia is dependent on the intracellular redox status of metastatic bladder cancer cells.
Regulation of MMP-9 by p53 in first trimester cytotrophoblastic cells.
Regulation of vascular endothelial growth factor expression by EMMPRIN via the PI3K-Akt signaling pathway.
Relation of matrilysin messenger RNA expression with invasive activity in human gastric cancer.
Relationship between matrix metalloproteinase expression and tumor angiogenesis in human breast carcinoma.
Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis.
Relaxed specificity of matrix metalloproteinases (MMPS) and TIMP insensitivity of tumor necrosis factor-alpha (TNF-alpha) production suggest the major TNF-alpha converting enzyme is not an MMP.
Remitted depression and cognition in HIV: The role of cortisol and inflammation.
Remodeling of collagen matrix by human tumor cells requires activation and cell surface association of matrix metalloproteinase-2.
Remodeling of the extracellular matrix by endothelial cell-targeting siRNA improves the EPR-based delivery of 100 nm particles.
Remodeling of the Tumor Microenvironment Predicts Increased Risk of Cancer in Postmenopausal Women: The Prospective Epidemiologic Risk Factor (PERF I) Study.
Renal cell neoplasias: reversion-inducing cysteine-rich protein with Kazal motifs discriminates tumor subtypes, while extracellular matrix metalloproteinase inducer indicates prognosis.
Reoxygenation using a novel CO2 therapy decreases the metastatic potential of osteosarcoma cells.
Replication study for reported SNP associations with breast cancer survival.
Repressing CD147 is a novel therapeutic strategy for malignant melanoma.
Repression of matrix metalloproteinases and inhibition of cell invasion by a nutrient mixture, containing ascorbic acid, lysine, proline, and green tea extract on human fanconi anemia fibroblast cell lines.
Requirement of arsenic biomethylation for oxidative DNA damage.
Rethinking Brain Cancer Therapy: Tumor Enzyme Activatable Theranostic Nanoparticles.
Retinoid-mediated suppression of tumor invasion and matrix metalloproteinase synthesis.
Reverse transcription-polymerase chain reaction phenotyping of metalloproteinases and inhibitors involved in tumor matrix invasion.
RHCG suppresses cervical cancer progression through inhibiting migration and inducing apoptosis regulated by TGF-?1.
Rheumatoid arthritis and salivary biomarkers of periodontal disease.
RNA interference targeting carbohydrate sulfotransferase 3 diminishes macrophage accumulation, inhibits MMP-9 expression and promotes lung recovery in murine pulmonary emphysema.
RNAi-mediated abrogation of cathepsin B and MMP-9 gene expression in a malignant meningioma cell line leads to decreased tumor growth, invasion and angiogenesis.
Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion.
Role of cancer cell-stroma interaction in invasive growth of cancer cells.
Role of lipocalin 2 and its complex with matrix metalloproteinase-9 in oral cancer.
Role of matrix metalloproteinase, tissue inhibitor of metalloproteinase and tumor necrosis factor-alpha single nucleotide gene polymorphisms in inflammatory bowel disease.
Role of matrix metalloproteinase-9 in progression of mouse skin carcinogenesis.
Role of matrix metalloproteinase-9 in transforming growth factor-?1-induced epithelial-mesenchymal transition in esophageal squamous cell carcinoma.
Role of matrix metalloproteinases and their inhibitors in pancreatic cancer.
Role of membrane type 1-matrix metalloproteinase and gelatinase A in head and neck squamous cell carcinoma invasion in vitro.
Role of serum vascular endothelial growth factor in the prediction of angiogenesis and prognosis for non-small cell lung cancer.
Role of the conserved histidine and aspartic acid residues in activity and stabilization of human gelatinase B: an example of matrix metalloproteinases.
Role of the matrix metalloproteinase and tissue inhibitors of metalloproteinase families in noninvasive and invasive tumors transplanted in mice with severe combined immunodeficiency.
Role of the V1G1 subunit of V-ATPase in breast cancer cell migration.
Role of thymosin beta4 in tumor metastasis and angiogenesis.
Roles of low-density lipoprotein receptor-related protein 1 in tumors.
Roles of the multifunctional glycoprotein, emmprin (basigin; CD147), in tumour progression.
Roles of the ovarian surface epithelium in ovulation and carcinogenesis.
Rotational stress-induced increase in epinephrine levels delays cutaneous wound healing in mice.
RSPO1-mutated fibroblasts from non-tumoural areas of palmoplantar keratoderma display a cancer-associated phenotype.
S-adenosylmethionine, a methyl donor, up regulates tissue inhibitor of metalloproteinase-2 in colorectal cancer.
Salvianolic Acid B Slows the Progression of Breast Cancer Cell Growth via Enhancement of Apoptosis and Reduction of Oxidative Stress, Inflammation, and Angiogenesis.
Secretion and Expression of Matrix Metalloproteinase-2 and 9 from Bone Marrow Mononuclear Cells in Myelodysplastic Syndrome and Acute Myeloid Leukemia.
Secretions of MMP-9 by soluble glucocorticoid-induced tumor necrosis factor receptor (sGITR) mediated by protein kinase C (PKC)delta and phospholipase D (PLD) in murine macrophage.
Secretory Leukoprotease Inhibitor: A Native Antimicrobial Protein in the Innate Immune Response in a Rat Model of S. aureus Keratitis.
Selection of peptide inhibitor to matrix metalloproteinase-2 using phage display and its effects on pancreatic cancer cell lines PANC-1 and CFPAC-1.
Selective hydrolysis of triple-helical substrates by matrix metalloproteinase-2 and -9.
Selective matrix metalloproteinase (MMP) inhibitors in cancer therapy: ready for prime time?
Selective Matrix Metalloproteinase Inhibitors for Cancer.
Selective modulation of matrix metalloproteinase 9 (MMP-9) functions via exosite inhibition.
Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion.
Sensitive detection of CD147/EMMPRIN and its expression on cancer cells with electrochemical technique.
Sensitivity of human cord blood cells to tetrachloroethylene: cellular and molecular endpoints.
Sequential activation of anticancer therapy triggered by tumor microenvironment-selective imaging.
Serum angiopoietin-like 4 is over-expressed in COPD patients: association with pulmonary function and inflammation.
Serum biomarkers differentiating Kawasaki disease from febrile infections: A pilot case-control study.
Serum matrix metalloproteinase-8 is associated with ulceration and vascular invasion of malignant melanoma.
Serum MMP-8 levels increase in colorectal cancer and correlate with disease course and inflammatory properties of primary tumors.
Serum soluble bone turnover biomarkers in psoriatic arthritis and psoriatic spondyloarthropathy.
Shape-Defined microPlates for the Sustained Intra-articular Release of Dexamethasone in the Management of Overload-Induced Osteoarthritis.
Shedding of the transferrin receptor is mediated constitutively by an integral membrane metalloprotease sensitive to tumor necrosis factor alpha protease inhibitor-2.
Shifts in biochemical markers associated with wound healing in laryngeal secretions following phonotrauma: a preliminary study.
Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells.
Significance of alternatively activated macrophages in patients with intrahepatic cholangiocarcinoma.
Significance of lymphatic invasion and cancer invasion-related proteins on lymph node metastasis in gastric cancer.
Significance of matrix metalloproteinases and tissue inhibitors of metalloproteinase expression in the recurrence of superficial transitional cell carcinoma of the bladder.
Significance of semaphorin-3A and MMP-14 protein expression in non-small cell lung cancer.
Significant correlation between matrix metalloproteinase activity and tumor necrosis factor-alpha in salivary extravasation mucoceles.
Significant correlation of matrix metalloproteinase and macrophage colony-stimulating factor serum concentrations in patients with head and neck cancer.
Significant differences in the matrix metalloproteinase expression profiles of spontaneous medulloblastomas/primitive neuroectodermal tumors as compared with their xenografted, established tumor cell line derived counterparts.
Silencing CD147 inhibits tumor progression and increases chemosensitivity in murine lymphoid neoplasm P388D1 cells.
Silencing of TGF-?1 in tumor cells impacts MMP-9 in tumor microenvironment.
Silencing of the Metastasis Suppressor RECK by RAS Oncogene Is Mediated by DNA Methyltransferase 3b-Induced Promoter Methylation.
Simultaneous Inhibition of Tumor Necrosis Factor Receptor 1 and Matrix Metalloproteinase 8 Completely Protects Against Acute Inflammation and Sepsis.
Single Nucleotide Polymorphisms and Haplotypes of MMP-14 are Associated with the Risk and Pathological Development of Oral Cancer.
Single nucleotide polymorphisms in MMP1 and MMP3 gene promoters as risk factor in head and neck squamous cell carcinoma.
Small-molecule anticancer compounds selectively target the hemopexin domain of matrix metalloproteinase-9.
Smoking modulates interleukin-6:interleukin-10 and RANKL:osteoprotegerin ratios in the periodontal tissues.
Smoking-induced changes in cancer-related factors in patients with upper tract urothelial cancer.
SMYD3 promotes cancer invasion by epigenetic upregulation of the metalloproteinase MMP-9.
Snail levels control the migration mechanism of mesenchymal tumor cells.
Soluble aminopeptidase N/CD13 in malignant and nonmalignant effusions and intratumoral fluid.
Solution structure and backbone dynamics of the catalytic domain of matrix metalloproteinase-2 complexed with a hydroxamic acid inhibitor.
Solution structure of the catalytic domain of human stromelysin complexed with a hydrophobic inhibitor.
SPA0355, a thiourea analog, suppresses inflammatory responses and joint destruction in cultured fibroblast-like synoviocytes and collagen-induced arthritic mice.
Specific Inhibitor of Matrix Metalloproteinase Decreases Tumor Invasiveness After Radiofrequency Ablation in Liver Tumor Animal Model.
Sphingosine-1-phosphate reduces adhesion of malignant mammary tumor cells MDA-MB-231 to microvessel walls by protecting endothelial surface glycocalyx.
SPIONs embedded in polyamino acid nanogels to synergistically treat tumor microenvironment and breast cancer cells.
Sputum and salivary protein biomarkers and point-of-care biosensors for the management of COPD.
Squamous cell carcinoma growth in mice and in culture is regulated by c-Jun and its control of matrix metalloproteinase-2 and -9 expression.
Src-dependent phosphorylation of membrane type I matrix metalloproteinase on cytoplasmic tyrosine 573: role in endothelial and tumor cell migration.
Stage-IIB osteosarcomas around the knee. A study of MMP-9 in surviving tumour cells.
Status of research on matrix metalloproteinases (MMPs) in India.
Stimulation of matrix metalloproteinase production by recombinant extracellular matrix metalloproteinase inducer from transfected Chinese hamster ovary cells.
Stimulatory effects of EGF and TGF-alpha on invasive activity and 5'-deoxy-5-fluorouridine sensitivity in uterine cervical-carcinoma SKG-IIIb cells.
Strobilanthes crispus inhibits migration, invasion and metastasis in breast cancer.
Stroma-derived matrix metalloproteinase (MMP)-2 promotes membrane type 1-MMP-dependent tumor growth in mice.
Stromelysin 3, Ets-1, and vascular endothelial growth factor expression in oral precancerous and cancerous lesions: correlation with microvessel density, progression, and prognosis.
Stromelysin-1 (MMP-3) is inducible in T lymphoma cells and accelerates the growth of lymphoid tumors in vivo.
Stromelysin-1 promoter mutations impair gelatinase B activation in high microsatellite instability sporadic colorectal tumors.
Stromelysin-3 (ST-3): immunohistochemical characterization of the matrix metalloproteinase (MMP)-11 in benign and malignant skin tumours and other skin disorders.
Stromelysin-3 expression promotes tumor take in nude mice.
Structural characterization of the catalytic active site in the latent and active natural gelatinase B from human neutrophils.
Structural insights into the binding of MMP9 inhibitors.
Studies of a cobalt(III) complex of the MMP inhibitor marimastat: a potential hypoxia-activated prodrug.
Study of cardioprotective activity of the methanolic extract of the aerial parts of Bauhinia madagascariensis compared to Bauhinia purpurea against adrenaline-induced myocardial toxicity in rats.
Sublethal irradiation promotes the metastatic potential of hepatocellular carcinoma cells.
Subverting sterols: rerouting an oxysterol-signaling pathway to promote tumor growth.
Sudachitin Inhibits Matrix Metalloproteinase-1 and -3 Production in Tumor Necrosis Factor-?-Stimulated Human Periodontal Ligament Cells.
Sulphonamides: Deserving class as MMP inhibitors?
Superoxide- and NO-dependent mechanisms of antitumor and antimetastatic effect of L-arginine hydrochloride and coenzyme Q10.
Supervillin promotes tumor angiogenesis in liver cancer.
Suppression of liver tumor growth and metastasis by adiponectin in nude mice through inhibition of tumor angiogenesis and downregulation of Rho kinase/IFN-inducible protein 10/matrix metalloproteinase 9 signaling.
Suppression of matrilysin inhibits colon cancer cell invasion in vitro.
Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by bergamottin via the inhibition of protein kinase Cdelta/p38 mitogen-activated protein kinase and JNK/nuclear factor-kappaB-dependent matrix metalloproteinase-9 expression.
Suppressions of Migration and Invasion by Cantharidin in TSGH-8301 Human Bladder Carcinoma Cells through the Inhibitions of Matrix Metalloproteinase-2/-9 Signaling.
Suppressive effect of calcipotriol on the induction of matrix metalloproteinase (MMP)-9 and MMP-13 in a human squamous cell carcinoma cell line.
Supramolecular gelatin nanoparticles as matrix metalloproteinase responsive cancer cell imaging probes.
Synergistic Anticancer Effects of Vorinostat and Epigallocatechin-3-Gallate against HuCC-T1 Human Cholangiocarcinoma Cells.
Synergistic tumor suppression by adenovirus-mediated inhibitor of growth 4 and interleukin-24 gene cotransfer in hepatocarcinoma cells.
Synovial fluid gelatinase concentrations and matrix metalloproteinase and cytokine expression in naturally occurring joint disease in horses.
Synovial fluid levels of tumor necrosis factor-alpha in the inflamed rat knee: modulation by dexamethasone and inhibitors of matrix metalloproteinase and phosphodiesterase.
Synthesis and characterization of dextran-peptide-methotrexate conjugates for tumor targeting via mediation by matrix metalloproteinase II and matrix metalloproteinase IX.
Synthesis and Evaluation of a Novel Hydroxamate Based Fluorescent Photoprobe for Imaging of Matrix Metalloproteinases.
Synthesis and preliminary biological evaluation of new radioiodinated MMP inhibitors for imaging MMP activity in vivo.
Synthesis and preliminary evaluation in tumor bearing mice of new (18)f-labeled arylsulfone matrix metalloproteinase inhibitors as tracers for positron emission tomography.
Synthesis and structure-activity relationships of 4-alkynyloxy phenyl sulfanyl, sulfinyl, and sulfonyl alkyl hydroxamates as tumor necrosis factor-alpha converting enzyme and matrix metalloproteinase inhibitors.
Synthesis of radiolabeled biphenylsulfonamide matrix metalloproteinase inhibitors as new potential PET cancer imaging agents.
Synthesis, biodistribution and micro-PET imaging of a potential cancer biomarker carbon-11 labeled MMP inhibitor (2R)-2-[[4-(6-fluorohex-1-ynyl)phenyl]sulfonylamino]-3-methylbutyric acid [11C]methyl ester.
Synthesis, radiosynthesis, in vitro and preliminary in vivo evaluation of biphenyl carboxylic and hydroxamic matrix metalloproteinase (MMP) inhibitors as potential tumor imaging agents.
Synthetic matrix metalloproteinase inhibitors and tissue inhibitor of metalloproteinase (TIMP)-2, but not TIMP-1, inhibit shedding of tumor necrosis factor-alpha receptors in a human colon adenocarcinoma (Colo 205) cell line.
Synthetic peptides containing ITIM-like sequences of IREM-1 (CD300F) differentially regulate MyD88 and TRIF-mediated TLR signalling through activation of SHP and/or PI3K.
Systemic induction of the angiogenesis switch by the tetraspanin D6.1A/CO-029.
Systemic Th17-like cytokine pattern in gangrenous appendicitis but not in phlegmonous appendicitis.
Systems Biology-Derived Biomarkers to Predict Progression of Renal Function Decline in Type 2 Diabetes.
TAK1-TAB2 Signaling Contributes to Bone Destruction by Breast Carcinoma Cells.
Tangeretin, a citrus pentamethoxyflavone, exerts cytostatic effect via p53/p21 up-regulation and suppresses metastasis in 7,12-dimethylbenz(?)anthracene-induced rat mammary carcinoma.
Targeted blockade of JAK/STAT3 signaling inhibits ovarian carcinoma growth.
Targeted Disruption of the CXCL12/CXCR4 Axis Inhibits Osteolysis in a Murine Model of Myeloma-Associated Bone Loss.
Targeting CCR2 with its antagonist suppresses viability, motility and invasion by downregulating MMP-9 expression in non-small cell lung cancer cells.
Targeting CD147 is a novel strategy for antitumor therapy.
Targeting invadopodia-mediated breast cancer metastasis by using ABL kinase inhibitors.
Targeting L1 cell adhesion molecule expression using liposome-encapsulated siRNA suppresses prostate cancer bone metastasis and growth.
Targeting matrix metalloproteinase MMP3 greatly enhances oncolytic virus mediated tumor therapy.
Targeting neutrophil collagenase/matrix metalloproteinase-8 and gelatinase B/matrix metalloproteinase-9 with a peptidomimetic inhibitor protects against endotoxin shock.
Targeting of an antecedent proteinase by an activatable probe with deep tissue penetration facilitates early visualization and dynamic malignancy evaluation of orthotopic pancreatic ductal adenocarcinoma (PDAC).
Tenocyte activation and regulation of complement factors in response to in vitro cell injury.
Terminalia Chebulanin Attenuates Psoriatic Skin Lesion via Regulation of Heme Oxygenase-1.
Tetraspanin CD9 promotes the invasive phenotype of human fibrosarcoma cells via upregulation of matrix metalloproteinase-9.
TGF-?1 facilitates MT1-MMP-mediated proMMP-9 activation and invasion in oral squamous cell carcinoma cells.
The 2G allele of promoter region of Matrix metalloproteinase-1 as an essential pre-condition for the early onset of oral squamous cell carcinoma.
The altered glucose metabolism in tumor and a tumor acidic microenvironment associated with extracellular matrix metalloproteinase inducer and monocarboxylate transporters.
The angiogenic switch of human colon cancer occurs simultaneous to initiation of invasion.
The anti-metastatic activity of collagenase-2 in breast cancer cells is mediated by a signaling pathway involving decorin and miR-21.
The association between individual SNPs or haplotypes of matrix metalloproteinase 1 and gastric cancer susceptibility, progression and prognosis.
The association of genotype polymorphisms with vascular access patency in hemodialysis patients.
The beneficial effect of cold atmospheric plasma on parameters of molecules and cell function involved in wound healing in human osteoblast-like cells in vitro.
The C-terminal region of membrane type matrix metalloproteinase is a functional transmembrane domain required for pro-gelatinase A activation.
The C-terminus of ephrin-B1 regulates metalloproteinase secretion and invasion of cancer cells.
The chemopreventive properties of chlorogenic acid reveal a potential new role for the microsomal glucose-6-phosphate translocase in brain tumor progression.
The clinicopathological significance and prognostic value of EMMPRIN overexpression in cancers: evidence from 39 cohort studies.
The combined effects of celecoxib and minocycline hydrochloride on inhibiting the osseous metastasis of breast cancer in nude mice.
The Contribution of Matrix Metalloproteinase-7 Promoter Genotypes in Breast Cancer in Taiwan.
The Contribution of MMP-7 Promoter Polymorphisms in Renal Cell Carcinoma.
The Contribution of MMP-8 Promoter Genotypes to Childhood Leukemia.
The detection of Helicobacter pylori cag pathogenicity islands (PAIs) and expression of matrix metalloproteinase-7 (MMP-7) in gastric epithelial dysplasia and intramucosal cancer.
The Dynamics of CD147 in Alzheimer's Disease Development and Pathology.
The effect of a single episode of antimicrobial photodynamic therapy in the treatment of experimental periodontitis. Microbiological profile and cytokine pattern in the dog mandible.
The effect of diabetes on vitreous levels of adiponectin and inflammatory cytokines in experimental rat model.
The effect of dietary supplementation with limonene or myo-inositol on the induction of neoplasia and matrix metalloproteinase and plasminogen activator activities in accessory sex organs of male Lobund-Wistar rats.
The effect of tomatine on metastasis related matrix metalloproteinase (MMP) activities in breast cancer cell model.
The effects of interleukin-18 on rat articular chondrocytes: a study of mRNA expression and protein synthesis of proinflammatory substances.
The Elastin Receptor Complex: A Unique Matricellular Receptor with High Anti-tumoral Potential.
The expression of apoptotic proteins and matrix metalloproteinases in odontogenic myxomas.
The expression of matrix metalloproteinases in intrahepatic cholangiocarcinoma, hilar (Klatskin tumor), middle and distal extrahepatic cholangiocarcinoma, gallbladder cancer, and ampullary carcinoma: role of matrix metalloproteinases in tumor progression and prognosis.
The Ezh2 polycomb group protein drives an aggressive phenotype in melanoma cancer stem cells and is a target of diet derived sulforaphane.
The FAM3C locus that encodes interleukin-like EMT inducer (ILEI) is frequently co-amplified in MET-amplified cancers and contributes to invasiveness.
The glycocalyx and its significance in human medicine.
The Goal of Cancer Treatment.
The high molecular weight urinary matrix metalloproteinase (MMP) activity is a complex of gelatinase B/MMP-9 and neutrophil gelatinase-associated lipocalin (NGAL). Modulation of MMP-9 activity by NGAL.
The HIV protease inhibitor indinavir down-regulates the expression of the pro-angiogenic MT1-MMP by human endothelial cells.
The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily.
The IGF-I Receptor Can Alter the Matrix Metalloproteinase Repertoire of Tumor Cells through Transcriptional Regulation of PKC-{alpha}
The Impact of Matrix Metalloproteinase-9 on the Sequential Steps of the Metastatic Process.
The indirect antiangiogenic effect of IL-37 in the tumor microenvironment.
The influence of repeated arthrocentesis and exercise on matrix metalloproteinase and tumour necrosis factor alpha activities in normal equine joints.
The influence of transforming growth factor-?, cyclooxygenase-2, matrix metalloproteinase (MMP)-7, MMP-9 and CXCR4 proteins involved in epithelial-mesenchymal transition on overall survival of patients with gastric cancer.
The insulin-like growth factor-1 elevates urokinase-type plasminogen activator-1 in human breast cancer cells: a new avenue for breast cancer therapy.
The integrin cytoplasmic-tail motif EKQKVDLSTDC is sufficient to promote tumor cell invasion mediated by matrix metalloproteinase (MMP)-2 or MMP-9.
The interplay of matrix metalloproteinase-8, transforming growth factor-?1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma.
The intranuclear PEX domain of MMP involves proliferation, migration, and metastasis of aggressive adenocarcinoma cells.
The Kazal motifs of RECK protein inhibit MMP-9 secretion and activity and reduce metastasis of lung cancer cells in vitro and in vivo.
The many faces of EMMPRIN-Roles in neuroinflammation.
The matrix metalloproteinase inhibitor batimastat (BB-94) retards human breast cancer solid tumor growth but not ascites formation in nude mice.
The matrix metalloproteinase inhibitor batimastat inhibits the lung colonisation of orthotopically implanted malignant pancreatic tumor cells in SCID mice.
The matrix metalloproteinase inhibitor prinomastat enhances photodynamic therapy responsiveness in a mouse tumor model.
The matrix metalloproteinase matrilysin influences early-stage mammary tumorigenesis.
The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter.
The matrix metalloproteinase system in oral squamous cell carcinoma.
The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers.
The membrane-anchored metalloproteinase regulator RECK stabilizes focal adhesions and anterior-posterior polarity in fibroblasts.
The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors.
The metastasis-associated metalloproteinase stromelysin-3 is induced by transforming growth factor-beta in osteoblasts and fibroblasts.
The microtubule stabilizer patupilone counteracts ionizing radiation-induced matrix metalloproteinase activity and tumor cell invasion.
The microvesicle as a vehicle for EMMPRIN in tumor-stromal interactions.
The MMP-8 rs11225395 Promoter Polymorphism Increases Cancer Risk of Non-Asian Populations: Evidence from a Meta-Analysis.
The new synthetic matrix metalloproteinase inhibitor (Roche 28-2653) reduces tumor growth and prolongs survival in a prostate cancer standard rat model.
The novel non-immunological role and underlying mechanisms of B7-H3 in tumorigenesis.
The novel relationship between polycystic ovary syndrome and temporomandibular joint disorders.
The other side of MMPs: protective roles in tumor progression.
The overexpression and predictive significance of MMP-12 in esophageal squamous cell carcinoma.
The Pathological Significance and Prognostic Roles of Thrombospondin-1, and -2, and 4N1K-peptide in Bladder Cancer.
The PEA3 subfamily of Ets transcription factors synergizes with beta-catenin-LEF-1 to activate matrilysin transcription in intestinal tumors.
The phosphorylation of CD147 by Fyn plays a critical role for melanoma cells growth and metastasis.
The planar cell polarity protein Van Gogh-Like 2 regulates tumor cell migration and matrix metalloproteinase-dependent invasion.
The plasminogen activator and matrix metalloproteinase systems in colorectal cancer: relationship to tumour pathology.
The possible role of matrix metalloproteinase (MMP)-2 and MMP-9 in cancer, e.g. acute leukemia.
The preventive and curative effects of melatonin against abdominal aortic aneurysm in rats.
The prognostic role of tissue and serum MMP-1 and TIMP-1 expression in patients with non-small cell lung cancer.
The role of a single nucleotide polymorphism of the matrix metalloproteinase-1 gene promoter region in invasion and prognosis of meningiomas.
The role of EMMPRIN expression in ovarian epithelial carcinomas.
The role of exogenous Fibrinogen in cardiac surgery: stop bleeding or induce cardiovascular disease.
The role of extracellular matrix metalloproteinase inducer protein in prostate cancer progression.
The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis.
The role of matrix metalloproteinases in tumor invasion, metastasis, and angiogenesis.
The role of p300 histone acetyltransferase in UV-induced histone modifications and MMP-1 gene transcription.
The role of proteolytic enzymes in the pathology of epithelial ovarian carcinoma.
The Role of Smoking and Gingival Crevicular Fluid Markers on Coronally Advanced Flap Outcomes.
The role of SPARC in the TRAMP model of prostate carcinogenesis and progression.
The Role of the exocyst in matrix metalloproteinase secretion and actin dynamics during tumor cell invadopodia formation.
The Role of the Mediators of Inflammation in Cancer Development.
The significance of focal myoepithelial cell layer disruptions in human breast tumor invasion: a paradigm shift from the "protease-centered" hypothesis.
The silencing of ApoC3 suppresses oxidative stress and inflammatory responses in placenta cells from mice with preeclampsia via inhibition of the NF-?B signaling pathway.
The SOX2OT/miR-194-5p axis regulates cell proliferation and mobility of gastric cancer through suppressing epithelial-mesenchymal transition.
The Stromal Overexpression of CD10 in Invasive Breast Cancer and its Association with Clincophathologic Factors.
The synthesis and preliminary activity assay in vitro of peptide-like derivatives as APN inhibitors.
The targeted transduction of MMP-overexpressing tumor cells by ACPP-HPMA copolymer-coated adenovirus conjugates.
The tumor microenvironment promotes cancer progression and cell migration.
The tumor suppressor RECK interferes with HER-2/Neu dimerization and attenuates its oncogenic signaling.
The ubiquitin-proteasome system and inflammatory activity in diabetic atherosclerotic plaques: effects of rosiglitazone treatment.
The use of predictive or prognostic genetic biomarkers in endometrial and other hormone-related cancers: justification for extensive candidate gene single nucleotide polymorphism studies of the matrix metalloproteinase family and their inhibitors.
Therapeutic Angiogenesis of Human Early Endothelial Progenitor Cells Is Enhanced by Thrombomodulin.
Therapeutic effects of blocking ?-catenin against hepatocellular carcinoma-induced activation of inflammation, fibrosis and tumor invasion.
Therapeutic Effects of Three Human-derived Materials in a Mouse Corneal Alkali Burn Model.
Therapeutic Hypothermia Reduces the Inflammatory Response Following Ischemia/Reperfusion Injury in Rat Hearts.
Therapeutic Potential of Luteolin on Impaired Wound Healing in Streptozotocin-Induced Rats.
Thermoresponsive and Protease-Cleavable Interferon-Polypeptide Conjugates with Spatiotemporally Programmed Two-Step Release Kinetics for Tumor Therapy.
Thioredoxin fusion construct enables high-yield production of soluble, active matrix metalloproteinase-8 (MMP-8) in Escherichia coli.
Three Tiaobu Feishen formulae reduces cigarette smoke-induced inflammation in human airway epithelial cells.
Three-dimensional printing of Hela cells for cervical tumor model in vitro.
Thrombin generation and the pathogenesis of cancer.
Thrombin-thrombomodulin activation of protein C facilitates the activation of progelatinase A.
Thrombospondin-1-derived 4N1K peptide expression is negatively associated with malignant aggressiveness and prognosis in urothelial carcinoma of the upper urinary tract.
Thrombospondin-2 inhibits tumor cell invasion through the modulation of MMP-9 and uPA in pancreatic cancer cells.
Thrombospondin-4 promotes bladder cancer cell migration and invasion via MMP2 production.
Thuja orientalis reduces airway inflammation in ovalbumin-induced allergic asthma.
Thymidine phosphorylase promotes metastasis and serves as a marker of poor prognosis in hepatocellular carcinoma.
Thymoquinone inhibits IL-7-induced tumor progression and metastatic invasion in prostate cancer cells by attenuating matrix metalloproteinase activity and Akt/NF-?B signaling.
Time Course of the Phenotype of Blood and Bone Marrow Monocytes and Macrophages in the Lung after Cigarette Smoke Exposure In Vivo.
TIMP-1 Overexpression in Lung Carcinoma Enhances Tumor Kinetics and Angiogenesis in Brain Metastasis.
TIMP-2 (tissue inhibitor of metalloproteinase-2) regulates MMP-2 (matrix metalloproteinase-2) activity in the extracellular environment after pro-MMP-2 activation by MT1 (membrane type 1)-MMP.
TIMP1 and adverse prognosis in non-small cell lung cancer.
TIMP3 expression associates with prognosis in colorectal cancer and its novel arylsulfonamide inducer, MPT0B390, inhibits tumor growth, metastasis and angiogenesis.
Tissue inhibitor of matrix metalloproteinase-2 in nasopharyngeal carcinoma.
Tissue inhibitor of matrix metalloproteinase-3 levels in the extracellular matrix of lung, kidney, and eye increase with age.
Tissue inhibitor of metalloproteinase 3 suppresses tumor angiogenesis in matrix metalloproteinase 2-down-regulated lung cancer.
Tissue inhibitor of metalloproteinases-1 (TIMP-1) inhibits tumor growth and angiogenesis in the TIMP-1 transgenic mouse model.
Tissue inhibitor of metalloproteinases-4 inhibits but does not support the activation of gelatinase A via efficient inhibition of membrane type 1-matrix metalloproteinase.
Tissue inhibitors of metalloproteinase expression in human breast cancer: TIMP-3 is associated with adjuvant endocrine therapy success.
Tissue levels of active matrix metalloproteinase-2 and -9 in colorectal cancer.
TLR4-mediated hippocampal MMP/TIMP imbalance contributes to the aggravation of perioperative neurocognitive disorder in db/db mice.
TNF-alpha up-regulates matrix metalloproteinase-9 expression and activity in alveolar macrophages from patients with chronic obstructive pulmonary disease.
Toll-like receptor-4 agonist inhibits motility and invasion of hepatoblastoma HepG2 cells in vitro.
Topical imiquimod in the treatment of infantile hemangiomas: a retrospective study.
Towards third generation matrix metalloproteinase inhibitors for cancer therapy.
Toxicodendron vernicifluum Stokes extract inhibits solid tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice.
Transcriptional regulation of alcohol induced liver fibrosis in a translational porcine hepatocellular carcinoma model.
Transcriptional regulation of MMP-9 expression in stromal cells of human giant cell tumor of bone by tumor necrosis factor-alpha.
Transcriptional regulation of stromelysin-1 gene expression is altered during progression of mouse mammary epithelial cells from functionally normal to malignant.
Transformation-specific matrix metalloproteinases, MMP-7 and MMP-13, are present in epithelial cells of keratoacanthomas.
Transformed MDCK cells secrete elevated MMP1 that generates LAMA5 fragments promoting endothelial cell angiogenesis.
Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation.
Transforming growth factor beta1 acts as an inducer of matrix metalloproteinase expression and activity in human bone-metastasizing cancer cells.
Transgenic TIMP-1 inhibits simian virus 40 T antigen-induced hepatocarcinogenesis by impairment of hepatocellular proliferation and tumor angiogenesis.
Transinactivation of the epidermal growth factor receptor tyrosine kinase and focal adhesion kinase phosphorylation by dietary flavonoids: effect on invasive potential of human carcinoma cells.
Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin ?1.
Transplantation of fibroblasts that overexpress matrix metalloproteinase-3 into the site of spinal cord injury in rats.
Treatment of periodontitis reduces systemic inflammation in type 2 diabetes.
Treatment of Sorsby fundus dystrophy with anti-tumor necrosis factor-alpha medication.
Trefoil Factor 1 Suppresses Epithelial-mesenchymal Transition through Inhibition of TGF-beta Signaling in Gastric Cancer Cells.
Tryptophane-based biphenylsulfonamide matrix metalloproteinase inhibitors as tumor imaging agents.
Tumor and salivary matrix metalloproteinase levels are strong diagnostic markers of oral squamous cell carcinoma.
Tumor associated proteases -- prognostic markers of colorectal cancer.
Tumor cell surface-associated binding site for the M(r) 72,000 type IV collagenase.
Tumor marker potential of serum matrix metalloproteinases in patients with head and neck cancer.
Tumor Microenvironment-Associated Extracellular Matrix Components Regulate NK Cell Function.
Tumor necrosis factor receptor deficiency alters matrix metalloproteinase 13/tissue inhibitor of metalloproteinase 1 expression in murine silicosis.
Tumor necrosis factor receptor-associated factor 6 (TRAF6) inhibition modulates bone loss and matrix metalloproteinase expression levels in collagen-induced rheumatoid arthritis rat.
Tumor necrosis factor-?-accelerated degradation of type I collagen in human skin is associated with elevated matrix metalloproteinase (MMP)-1 and MMP-3 ex vivo.
Tumor necrosis factor-alpha and its receptors, p55 and p75, in gingiva of adult periodontitis.
Tumor necrosis factor-alpha G(-308)A promoter polymorphism, matrix metalloproteinase (MMP)-3 5A/6A gene variation, MMP-9 C(-1562)T promoter polymorphism and risk and extent of ischemic heart disease.
Tumor necrosis factor-alpha neutralization reduced cerebral edema through inhibition of matrix metalloproteinase production after transient focal cerebral ischemia.
Tumor necrosis factor-alpha-induced matrix proteolytic enzyme production and basement membrane remodeling by human ovarian surface epithelial cells: molecular basis linking ovulation and cancer risk.
Tumor progression: defining the soil round the tumor seed.
Tumor regression and curability of preclinical neuroblastoma models by PEGylated SN38 (EZN-2208), a novel topoisomerase I inhibitor.
Tumor suppression by control of matrix metalloproteinase recycling.
Tumor targeting with a selective gelatinase inhibitor.
Tumor vesicle-associated CD147 modulates the angiogenic capability of endothelial cells.
Tumor-derived death receptor 6 modulates dendritic cell development.
Tumor-derived EMMPRIN (extracellular matrix metalloproteinase inducer) stimulates collagenase transcription through MAPK p38.
Tumor-fibroblast interactions stimulate tumor vascularization by enhancing cytokine-driven production of MMP9 by tumor cells.
Tumor-recruited M2 macrophages promote gastric and breast cancer metastasis via M2 macrophage-secreted CHI3L1 protein.
Tumor-stroma interaction: positive feedback regulation of extracellular matrix metalloproteinase inducer (EMMPRIN) expression and matrix metalloproteinase-dependent generation of soluble EMMPRIN.
Tumor-stromal interactions of the bone microenvironment: in vitro findings and potential in vivo relevance in metastatic lung cancer models.
Tumorigenic potential of extracellular matrix metalloproteinase inducer.
Tumour metastasis to the liver, and the roles of proteinases and adhesion molecules: new concepts from in vivo videomicroscopy.
Tumour necrosis factor-alpha provokes upregulation of alpha2beta1 and alpha5beta1 integrins, and cell migration in OST osteosarcoma cells.
Tuning Liposome Membrane Permeability by Competitive Peptide Dimerization and Partitioning-Folding Interactions Regulated by Proteolytic Activity.
Two-photon laser-generated microtracks in 3D collagen lattices: principles of MMP-dependent and -independent collective cancer cell invasion.
Type I and III collagen degradation products in serum predict patient survival in head and neck squamous cell carcinoma.
Type IV collagenases in tumor invasion and metastasis.
Ultrasound-guided intratumoral administration of collagenase-2 improved liposome drug accumulation in solid tumor xenografts.
Ultrastructural and cytobiological studies on possible interactions between PTHrP-secreting tumor cells, stromal cells, and bone cells.
Unique proliferation response in odontoblastic cells derived from human skeletal muscle stem cells by cytokine-induced matrix metalloproteinase-3.
Up-regulated DERL3 in fibroblast-like synoviocytes exacerbates inflammation of rheumatoid arthritis.
Up-regulated EMMPRIN/CD147 protein expression might play a role in colorectal carcinogenesis and its subsequent progression without an alteration of its glycosylation and mRNA level.
Up-regulated gene expression of angiogenesis factors in post-chemotherapeutic lung cancer tissues determined by cDNA macroarray.
Up-regulated p27Kip1 reduces matrix metalloproteinase-9 and inhibits invasion of human breast cancer cells.
Up-regulation of fibronectin and tissue transglutaminase promotes cell invasion involving increased association with integrin and MMP expression in A431 cells.
Up-regulation of matrix metalloproteinase family gene involvement in ursolic acid-induced human lung non-small carcinoma cell apoptosis.
Up-regulation of matrix metalloproteinase-8 by betel quid extract and arecoline and its role in 2D motility.
Up-regulation of vascular endothelial growth factor by membrane-type 1 matrix metalloproteinase stimulates human glioma xenograft growth and angiogenesis.
Update analysis of studies on the MMP-9 -1562 C>T polymorphism and cancer risk.
Update meta-analysis on MMP-7 -181A>G polymorphism and cancer risk: evidence from 25 studies.
Upregulated Expression of ADAM17 Is a Prognostic Marker for Patients With Gastric Cancer.
Upregulated matrix metalloproteinase-2 and downregulated tissue factor pathway inhibitor-2 are risk factors for lymph node metastasis and perineural invasion in pancreatic carcinoma.
Upregulation of circulating cytokeratin 20, urokinase plasminogen activator and C-reactive protein is associated with poor prognosis in gastric cancer.
Upregulation of discoidin domain receptor 2 in nasopharyngeal carcinoma.
Upregulation of extracellular matrix metalloproteinase inducer promotes hypoxia-induced epithelial-mesenchymal transition in esophageal cancer.
Upregulation of human heme oxygenase gene expression by Ets-family proteins.
Upregulation of RECK gene expression by small double-stranded RNA targeting the promoter region.
Urinary matrix metalloproteinases-2/9 in healthy infants and haemangioma patients prior to and during propranolol therapy.
Urinary VEGF and MMP levels as predictive markers of 1-year progression-free survival in cancer patients treated with radiation therapy: a longitudinal study of protein kinetics throughout tumor progression and therapy.
Ursolic acid alleviates early brain injury after experimental subarachnoid hemorrhage by suppressing TLR4-mediated inflammatory pathway.
Ursolic acid and its esters: occurrence in cranberries and other Vaccinium fruit and effects on matrix metalloproteinase activity in DU145 prostate tumor cells
Ursolic acid and its esters: occurrence in cranberries and other Vaccinium fruit and effects on matrix metalloproteinase activity in DU145 prostate tumor cells.
Use of Edman degradation sequence analysis and matrix-assisted laser desorption/ionization mass spectrometry in designing substrates for matrix metalloproteinases.
Use of IL-1 ?, IL-6, TNF-?, and MMP-8 biomarkers to distinguish peri-implant diseases: A systematic review and meta-analysis.
Use of tetracycline as an inhibitor of matrix metalloproteinase activity secreted by human bone-metastasizing cancer cells.
Vaccinia virus-mediated intra-tumoral expression of matrix metalloproteinase 9 enhances oncolysis of PC-3 xenograft tumors.
Valine-based biphenylsulphonamide matrix metalloproteinase inhibitors as tumor imaging agents.
Variability in C-reactive protein is associated with cognitive impairment in women living with and without HIV: a longitudinal study.
Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas.
Vascular endothelial growth factor (VEGF) induces matrix metalloproteinase expression in immortalized chondrocytes.
Vascular endothelial growth factor activating matrix metalloproteinase in ascitic fluid during peritoneal dissemination of ovarian cancer.
Vascular endothelial growth factor expression in the basal subtype of breast carcinoma.
Vascular endothelial growth factor expression, angiogenesis, and necrosis in renal cell carcinomas.
Vascular repair and anti-inflammatory effects of soluble epoxide hydrolase inhibitor.
Vasculogenic mimicry is associated with high tumor grade, invasion and metastasis, and short survival in patients with hepatocellular carcinoma.
Violacein inhibits matrix metalloproteinase mediated CXCR4 expression: potential anti-tumor effect in cancer invasion and metastasis.
Wild-type p53 gene transfer inhibits invasion and reduces matrix metalloproteinase-2 levels in p53-mutated human melanoma cells.
Within-subject variability in repeated measures of salivary analytes in healthy adults.
Zebrafish Xenograft: An Evolutionary Experiment in Tumour Biology.
Zingiber mioga (Thunb.) Roscoe attenuates allergic asthma induced by ovalbumin challenge.
ZKSCAN3 promotes bladder cancer cell proliferation, migration, and invasion.
Zn(II)-Chlorido complexes of phytohormone kinetin and its derivatives modulate expression of inflammatory mediators in THP-1 cells.
[A Simple Medical Research Microdevice for Analyzing Three-dimensional Migration of Tumor Cells in Vitro].
[Antiangiogenic and antitumor effect of BPHA, an orally-active matrix metalloproteinase inhibitor, in in vivo murine and human tumor model]
[Assay of matrix metalloproteinase levels and their endogenous inhibitors in patients with laryngeal carcinoma]
[Collagenase-3 (MMP-13) expression in epithelial cancers of the eyelids]
[Construction and Anti-tumor Effect Evaluation of a Dual-Responsive Hyaluronic Acid Carbon Quantum Dot-Gelatin Nano-Drug Delivery System].
[Correlation between expressions of matrix metalloproteinase-2 & 9 and vasculogenic mimicry in gastrointestinal stromal tumors]
[Correlation of membrane type I matrix metalloproteinase (MT1-MMP) expression with clinicomorphological features of tumor front in squamous cell carcinoma of the larynx]
[Current data on metalloproteinases, obligatory partners of tumor progression]
[Detection of stromelysin mRNA expression in human hepatocellular carcinoma by in situ hybridization]
[Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid]
[Effect of Gancao Fuzi Decoction on osteoarthritis and proteomics of articular cartilage in rats].
[Effect of short-hairpin RNA expression vector-mediated osteopontin RNA interference on proliferation and invasion of prostate cancer PC-3 cells]
[Effects of alprostadil and ulinastatin on inflammatory response and lung injury after cardiopulmonary bypass in pediatric patients with congenital heart diseases]
[Effects of tamoxifen on apoptosis and matrix metalloproteinase-7 expression in estrogen receptor beta-positive colorectal cancer cell line HT-29]
[EMMPRIN (CD147). A prognostic and potentially therapeutic marker in urothelial cancer].
[Expression and clinical significance of CD147 and MMP-2 ?in squamous cell carcinoma and adenocarcinoma of the lungs].
[Expression and clinical significance of matrix metalloproteinase in gastric stromal tumor]
[Expression and clinicopathologic significance of OPN, CD44v6 and MMP-2 in squamous cell carcinoma and adenocarcinoma of the lung].
[Expression of dishevelled-2 in cartilage of rheumatoid arthritis and its effect on cartilage destruction].
[Expression of extracellular matrix metalloproteinase inducer in human bladder transitional cell carcinoma]
[Expression of matrix metalloproteinases in patients with malignant tumors]
[Expression of miR-146b in peripheral blood serum and aortic tissues in patients with acute type Stanford A aortic dissection and its clinical significance].
[Inflammatory-destructive biomarkers of atherosclerotic plaques instability. Study of arterial wall and blood].
[Intervention of Qingshen Granule for Immune Inflammation of Chronic Renal Failure Patients with Damp-heat Syndrome].
[Matrix metalloproteinase 2 and 9 as the factor of head and neck tumor metastasis]
[Matrix metalloproteinase inhibitors for therapy of cancer]
[Morphological tumor front grading and matrix metalloproteinases type I expression as a prognostic parameter of the presence of lymph node micrometastases in laryngeal carcinoma]
[Non-specific immunotherapy inhibits angiogenesis - results of the monitoring of serum levels of vascular endothelial growth factor and matrix metalloproteinase 8 in patients with malignant melanoma receiving adjuvant high-dose interferon therapy].
[Pathological features of lymph node metastasis. 2) From morphological aspects]
[Phenotypic and functional characteristics of endothelial cells derived from human liver cancer]
[Recent progress of matrix metalloproteinase (MMP) research and its clinical application for cancer therapy]
[Regulation of Ruxolitinib on matrix metalloproteinase in JAK2V617F positive myeloroliferative neoplasms cells].
[Relationship between expression of matrix metalloproteinase (MMP-9) and tumor angiogenesis, cancer cell proliferation, invasion, and metastasis in invasive carcinoma of cervix]
[Role of a latent soluble TNF receptor type I (hsTNFRI) fusion protein in targeted treatment of endometriosis]
[Role of cytokine-matrix metalloproteinase axis on promoting vascular neointima hyperplasia in mice].
[Study on expression of matrix metalloproteinases and their inhibitors in parotid gland tumors]
[The basement membrane and metastasis]
[The expressions of TNF-alpha and MMP-9 in serum and MMP-1 mRNA in the bone tissue in chronic obstructive pulmonary disease patients of cold dryness syndrome in northwest China].
[The matrix metalloproteinase in oral and oropharyngeol cancer - literature review].
[The role of metalloproteinases in modification of extracellular matrix in invasive tumor growth, metastasis and angiogenesis].
[The role of stromal mast cells in the modification of CD4+CD25+Foxp³ regulatory T cells, Th17 lymphocytes and cytotoxic lymphocytes Tc1 in the development and progression of tumor].
[Tumor metastasis and MMP inhibitor.]
[Urothelial tumors and the extracellular matrix]
ß-1,3-galactosyl-O-glycosyl-glycoprotein ß-1,6-N-acetylglucosaminyltransferase 3 Increases MCAM Stability, Which Enhances S100A8/A9-Mediated Cancer Motility.
Neoplasms, Squamous Cell
Plasma level of tissue inhibitor of matrix metalloproteinase-1 but not that of matrix metalloproteinase-8 predicts survival in head and neck squamous cell cancer.
Neoplastic Cells, Circulating
NanoVelcro-captured CTC number concomitant with enhanced serum levels of MMP7 and MMP9 enables accurate prediction of metastasis and poor prognosis in patients with lung adenocarcinoma.
Pulmonary vascular destabilization in the premetastatic phase facilitates lung metastasis.
Nephritis
A unique hybrid renal mononuclear phagocyte activation phenotype in murine systemic lupus erythematosus nephritis.
Decrease in cell proliferation by an matrix metalloproteinase inhibitor, doxycycline, in a model of immune-complex nephritis.
Participation of the matrix metalloproteinase inhibitor in Thy-1 nephritis.
Renoprotective action of a matrix metalloproteinase inhibitor in progressive mesangioproliferative nephritis.
The gene expression profile of matrix metalloproteinases and their inhibitors in children with Henoch-Schönlein purpura.
Nephritis, Hereditary
Biomechanical strain causes maladaptive gene regulation, contributing to Alport glomerular disease.
Matrix metalloproteinase dysregulation in the stria vascularis of mice with Alport syndrome: implications for capillary basement membrane pathology.
Nervous System Diseases
Marine pharmacology: therapeutic targeting of matrix metalloproteinases in neuroinflammation.
Matrix metalloproteinases in the cerebrospinal fluid of patients with Lyme neuroborreliosis.
Neuralgia
Biomarker Analysis of Orally Dosed, Dual Active, Matrix Metalloproteinase (MMP)-2 and MMP-9 Inhibitor, AQU-118, in the Spinal Nerve Ligation (SNL) Rat Model of Neuropathic Pain.
N-acetyl-cysteine attenuates neuropathic pain by suppressing matrix metalloproteinases.
Paeoniflorin attenuates postoperative pain by suppressing Matrix Metalloproteinase-9/2 in mice.
Procyanidins attenuate neuropathic pain by suppressing matrix metalloproteinase-9/2.
Spatial and temporal analysis of nociception-related spinal cord matrix metalloproteinase expression in a murine neuropathic pain model.
Neuritis
A combined inhibitor of matrix metalloproteinase activity and tumour necrosis factor-alpha processing attenuates experimental autoimmune neuritis.
Matrix metalloproteinase expression during experimental autoimmune neuritis.
MMP-mediated cleavage of beta-dystroglycan in myelin sheath is involved in autoimmune neuritis.
Neuritis, Autoimmune, Experimental
A combined inhibitor of matrix metalloproteinase activity and tumour necrosis factor-alpha processing attenuates experimental autoimmune neuritis.
Matrix metalloproteinase expression during experimental autoimmune neuritis.
Neuroblastoma
All-trans-retinoic acid induces nuclear factor kappaB activation and matrix metalloproteinase-9 expression and enhances basement membrane invasivity of differentiation-resistant human SK-N-BE 9N neuroblastoma Cells.
Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk.
Induction of matrix metalloproteinase MMP-9 (92-kDa gelatinase) by retinoic acid in human neuroblastoma SKNBE cells: relevance to neuronal differentiation.
Rapid Unperturbed-Tissue Analysis for Intraoperative Cancer Diagnosis Using an Enzyme-Activated NIR-II Nanoprobe.
Tissue inhibitor of metalloproteinase-2 (TIMP-2) expression is regulated by multiple neural differentiation signals.
Neurocysticercosis
Doxycycline treatment decreases morbidity and mortality of murine neurocysticercosis: evidence for reduction of apoptosis and matrix metalloproteinase activity.
Neurodegenerative Diseases
Chemical biology for understanding matrix metalloproteinase function.
Exploring the Association Between Rosacea and Parkinson Disease: A Danish Nationwide Cohort Study.
Mechanistic Insights into Side Effects of Troglitazone and Rosiglitazone Using a Novel Inverse Molecular Docking Protocol.
Molecular Targets for PET Imaging of Activated Microglia: The Current Situation and Future Expectations.
Recent insights into natural product inhibitors of matrix metalloproteinases.
Neuroectodermal Tumors
Matrix metalloproteinase expression in childhood medulloblastomas/primitive neuroectodermal tumors.
Significant differences in the matrix metalloproteinase expression profiles of spontaneous medulloblastomas/primitive neuroectodermal tumors as compared with their xenografted, established tumor cell line derived counterparts.
Neuroinflammatory Diseases
Anti-inflammatory and anti-oxidant mechanisms of an MMP-8 inhibitor in lipoteichoic acid-stimulated rat primary astrocytes: involvement of NF-?B, Nrf2, and PPAR-? signaling pathways.
Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-alpha, releasing matrix metalloproteinase-9 and migrating in vitro.
Evaluation of matrix metalloproteinase-9 plasma levels in untreated new Relapsing-remitting multiple sclerosis patients and their first-degree family.
Flavonoids targeting of I?B phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells.
Fluorometric immunocapture assay for the specific measurement of matrix metalloproteinase-9 activity in biological samples: application to brain and plasma from rats with ischemic stroke.
Galangin Inhibits Thrombin-Induced MMP-9 Expression in SK-N-SH Cells via Protein Kinase-Dependent NF-?B Phosphorylation.
High Serum Tissue Inhibitor of Matrix Metalloproteinase-1 Levels and Mortality in Patients with Spontaneous Intracerebral Hemorrhage.
Intercellular Adhesion Molecule-1-Induced Posttraumatic Brain Injury Neuropathology in the Prefrontal Cortex and Hippocampus Leads to Sensorimotor Function Deficits and Psychological Stress.
Ligation of the jugular veins does not result in brain inflammation or demyelination in mice.
Matrix metalloproteinase inhibitors attenuate neuroinflammation following focal cerebral ischemia in mice.
Matrix Metalloproteinase-8 Inhibition Prevents Disruption of Blood-Spinal Cord Barrier and Attenuates Inflammation in Rat Model of Spinal Cord Injury.
Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF-? activation.
Multimodal Molecular Imaging Demonstrates Myeloperoxidase Regulation of Matrix Metalloproteinase Activity in Neuroinflammation.
Paeoniflorin attenuates postoperative pain by suppressing Matrix Metalloproteinase-9/2 in mice.
Regulation of neuroinflammation by matrix metalloproteinase-8 inhibitor derivatives in activated microglia and astrocytes.
Suppression of neuroinflammation by matrix metalloproteinase-8 inhibitor in aged normal and LRRK2 G2019S Parkinson's disease model mice challenged with lipopolysaccharide.
Neurologic Manifestations
Simvastatin in traumatic brain injury: Effect on brain edema mechanisms.
Neuroma, Acoustic
Cystic vestibular schwannomas: a possible role of matrix metalloproteinase-2 in cyst development and unfavorable surgical outcome.
Neuromyelitis Optica
MMP-2 -1575G/A polymorphism modifies the onset of optic neuritis as a first presenting symptom in MS?
neutrophil collagenase deficiency
Collagenase-2 deficiency or inhibition impairs experimental autoimmune encephalomyelitis in mice.
Matrix metalloproteinase 8 deficiency in mice exacerbates inflammatory arthritis through delayed neutrophil apoptosis and reduced caspase 11 expression.
Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response.
Matrix metalloproteinase deficiencies do not impair cell-associated fibrinolytic activity.
Matrix metalloproteinase-8 deficiency increases joint inflammation and bone erosion in the K/BxN serum-transfer arthritis model.
Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation.
MMP-8 deficiency increases TLR/RAGE ligands S100A8 and S100A9 and exacerbates lung inflammation during endotoxemia.
Nevus
TGF-? signaling, activated stromal fibroblasts, and cysteine cathepsins B and L drive the invasive growth of human melanoma cells.
Nevus, Pigmented
Prognostic significance of phosphorylated signal transducer and activator of transcription 3 and suppressor of cytokine signaling 3 expression in human cutaneous melanoma.
Newcastle Disease
Assay of extracellular matrix degradation and transmigration of chicken peripheral blood mononuclear cells after infection with genotype VII Newcastle disease virus in vitro.
Matrix metalloproteinase-14 regulates collagen degradation and migration of mononuclear cells during infection with genotype VII Newcastle disease virus.
Non-alcoholic Fatty Liver Disease
Interactions of central obesity with rs3918242 on risk of non-alcoholic fat liver disease: a preliminary case-control study.
Obesity
A case of 14q11.2 microdeletion with autistic features, severe obesity and facial dysmorphisms suggestive of Wolf-Hirschhorn syndrome.
Association of MMP-8 with obesity, smoking and insulin resistance.
Diet-induced Obesity and Matrix Metalloproteinase Gene Expression at the Onset of Skeletal Muscle Regeneration: 2078 Board #230 June 2, 2: 00 PM - 3: 30 PM.
Diet-induced obesity and reduced skin cancer susceptibility in matrix metalloproteinase 19-deficient mice.
Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women.
Effect of gelatinase inhibition on adipogenesis and adipose tissue development.
Evaluation of plasmatic MMP-8, MMP-9, TIMP-1 and MPO levels in obese and lean women.
Genetic variants associated with circulating MMP1 levels near matrix metalloproteinase genes on chromosome 11q21-22 in Taiwanese: interaction with obesity.
Hydrogen Sulfide Depletion Contributes to Microvascular Remodeling in Obesity.
Kidney osteoclast factors and matrix metalloproteinase expression in a mice model of diet-induced obesity and diabetes.
Korean red ginseng (Panax ginseng) prevents obesity by inhibiting angiogenesis in high fat diet-induced obese C57BL/6J mice.
Leptin-induced matrix metalloproteinase-2 secretion is suppressed by trans-10,cis-12 conjugated linoleic acid.
Matrix metalloproteinase-1 promoter is associated with body mass index in Korean population with aged greater or equal to 50 years.
Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3-like protein 1.
Obesity and vascular risk.
Pam3CSK4 Induces MMP-9 Expression in Human Monocytic THP-1 Cells.
Tissue-specific differences in inflammatory infiltrate and matrix metalloproteinase expression in adipose tissue and liver of mice with diet-induced obesity.
Obesity, Abdominal
Interactions of central obesity with rs3918242 on risk of non-alcoholic fat liver disease: a preliminary case-control study.
Obesity, Maternal
Cellular inhibitors of apoptosis (cIAP) 1 and 2 are increased in placenta from obese pregnant women.
Obstetric Labor, Premature
Amniotic fluid matrix metalloproteinase-8 in preterm labor with intact membranes.
Amniotic fluid matrix metalloproteinase-8 indicates intra-amniotic infection.
An elevated amniotic fluid prostaglandin F2? concentration is associated with intra-amniotic inflammation/infection, and clinical and histologic chorioamnionitis, as well as impending preterm delivery in patients with preterm labor and intact membranes.
Changes in matrix metalloproteinase (MMP)-2 and MMP-9 in the fetal amnion and chorion during gestation and at term and preterm labor.
Clinical significance of oligohydramnios in patients with preterm labor and intact membranes*,**.
Comparison of rapid MMP-8 and interleukin-6 point-of-care tests to identify intra-amniotic inflammation/infection and impending preterm delivery in patients with preterm labor and intact membranes().
Human neutrophil collagenase (matrix metalloproteinase 8) in parturition, premature rupture of the membranes, and intrauterine infection.
Hyaluronidase Impairs Neutrophil Function and Promotes Group B Streptococcus Invasion and Preterm Labor in Nonhuman Primates.
Low maternal serum matrix metalloproteinase (MMP)-2 concentrations are associated with preterm labor and fetal inflammatory response.
Matrix metalloproteinases in the cervical mucus plug in relation to gestational age, plug compartment, and preterm labor.
Performance characteristics of putative tests for subclinical chorioamnionitis.
Progestin inhibits and thrombin stimulates the plasminogen activator/inhibitor system in term decidual stromal cells: implications for parturition.
Recombinant human lactoferrin inhibits matrix metalloproteinase (MMP-2, MMP-3, and MMP-9) activity in a rabbit preterm delivery model.
The frequency and clinical significance of intra-amniotic inflammation defined as an elevated amniotic fluid matrix metalloproteinase-8 in patients with preterm labor and low amniotic fluid white blood cell counts.
The frequency and clinical significance of intra-uterine infection and inflammation in patients with placenta previa and preterm labor and intact membranes.
[Extracellular matrix metalloproteases profile identification in chorioamniotic membranes of term and preterm pregnancies through soluble microarrays]
Ocular Hypertension
Bimatoprost, latanoprost, and tafluprost induce differential expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases.
Odontogenic Cysts
Expression and induction of collagenases (MMP-8 and -13) in plasma cells associated with bone-destructive lesions.
Expression of extracellular matrix metalloproteinase inducer in odontogenic cysts.
Intracystic negative pressure may promote bone formation around jaw cysts.
MMP-13 expression in keratocyst odontogenic tumour associated with NBCCS and sporadic keratocysts.
[Correlations of extrocellular matrix metalloproteinase inducer and microvessel density to invasiveness of ameloblastoma]
Odontogenic Tumors
Comparative analysis of the immunohistochemical expression of collagen IV, MMP-9, and TIMP-2 in odontogenic cysts and tumors.
Immunohistochemical detection of MT1-MMP, RECK, and EMMPRIN in ameloblastic tumors.
Matrix metalloproteinase expression in keratocystic odontogenic tumors and primary cells.
Oligohydramnios
Clinical significance of oligohydramnios in patients with preterm labor and intact membranes*,**.
Oncogene Addiction
Emerging Novel Therapeutic Agents in the Treatment of Patients with Gastroesophageal and Gastric Adenocarcinoma.
Oral Submucous Fibrosis
Matrix metalloproteinase (MMP)-2 and MMP-9 polymorphisms and haplotypes as disease biomarkers.
Osteoarthritis
A Mixture Containing Fermented Achyranthes japonica Nakai Ameliorates Osteoarthritis in Knee Joints of Monoiodoacetate-Injected Rats.
A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 8 (neutrophil collagenase) using monoclonal antibodies.
A Systematic Review of Basic Science and Animal Studies on the Use of Doxycycline to Reduce the Risk of Posttraumatic Osteoarthritis After Anterior Cruciate Ligament Rupture/Transection.
Aggravation of ADAMTS and Matrix Metalloproteinase Production and Role of ERK1/2 Pathway in the Interaction of Osteoarthritic Subchondral Bone Osteoblasts and Articular Cartilage Chondrocytes -- Possible Pathogenic Role in Osteoarthritis.
An insight to conserved water molecular dynamics of catalytic and structural Zn(+2) ions in matrix metalloproteinase 13 of human.
Analysis of the trajectory of osteoarthritis development in a mouse model by serial near-infrared fluorescence imaging of matrix metalloproteinase activities.
Assessment of the effects of age and joint disease on hydroxyproline and glycosaminoglycan concentrations in synovial fluid from the metacarpophalangeal joint of horses.
Biologic basis of osteoarthritis: state of the evidence.
cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis.
Chemical biology for understanding matrix metalloproteinase function.
Chicken collagen type II reduces articular cartilage destruction in a model of osteoarthritis in rats.
Chondrocyte matrix metalloproteinase-8: up-regulation of neutrophil collagenase by interleukin-1 beta in human cartilage from knee and ankle joints.
CITED2 mediates the cross-talk between mechanical loading and IL-4 to promote chondroprotection.
Clinical trials of a stromelysin inhibitor. Osteoarthritis, matrix metalloproteinase inhibition, cartilage loss, surrogate markers, and clinical implications.
Clinical validation of an immunoaffinity LC-MS/MS assay for the quantification of a collagen type II neoepitope peptide: A biomarker of matrix metalloproteinase activity and osteoarthritis in human urine.
Comparison of Northern blot hybridization and a reverse transcriptase-polymerase chain reaction technique for measurement of mRNA expression of metalloproteinases and matrix components in articular cartilage and synovial membrane from horses with osteoarthritis.
Comparison of the pharmacology of hydroxamate- and carboxylate-based matrix metalloproteinase inhibitors (MMPIs) for the treatment of osteoarthritis.
Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification.
Curcumin and tetrahydrocurcumin both prevent osteoarthritis symptoms and decrease the expressions of pro-inflammatory cytokines in estrogen-deficient rats.
Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model.
Cystatin C in Cerebrospinal Fluid is Upregulated in Elderly Patients With Chronic Osteoarthritis Pain and Modulated Through Matrix Metalloproteinase 9-Specific Pathway.
Dark quenched matrix metalloproteinase fluorogenic probe for imaging osteoarthritis development in vivo.
Discovery of Potent, Selective, and Orally Active Carboxylic Acid Based Inhibitors of Matrix Metalloproteinase-13 (dagger).
DNA methylation of the RUNX2 P1 promoter mediates MMP13 transcription in chondrocytes.
Effect of an inhibitor of matrix metalloproteinases on spontaneous osteoarthritis in guinea pigs.
Effect of estrogen on the expression of matrix metalloproteinase (MMP)-1, MMP-3, and MMP-13 and tissue inhibitor of metalloproternase-1 in osteoarthritis chondrocytes.
Effect of inhibition of matrix metalloproteinases on cartilage loss in vitro and in a guinea pig model of osteoarthritis.
Effects of a metalloproteinase inhibitor on osteochondral angiogenesis, chondropathy and pain behavior in a rat model of osteoarthritis.
Effects of celecoxib on human chondrocytes--enhanced production of chemokines.
Effects of estradiol on reduction of osteoarthritis in rabbits through effect on matrix metalloproteinase proteins.
Evaluation of a magnetic resonance biomarker of osteoarthritis disease progression: doxycycline slows tibial cartilage loss in the Dunkin Hartley guinea pig.
Evaluation of the effect of oral administration of collagen peptides on an experimental rat osteoarthritis model.
Expression and correlation of matrix metalloproteinase-7 and interleukin-15 in human osteoarthritis.
Expression of collagenases (matrix metalloproteinase-1, 8, 13) and tissue inhibitor of metalloproteinase-1 of retrodiscal tissue in temporomandibular joint disorder patients.
Expression of matrix metalloproteinase 9 (96-kd gelatinase B) in human rheumatoid arthritis.
Expression of membrane type 1 matrix metalloproteinase in human articular cartilage.
Expression of membrane-type matrix metalloproteinases in synovial tissue from patients with rheumatoid arthritis or osteoarthritis.
Expression profiling of metalloproteinases and their inhibitors in cartilage.
Ferulic acid suppresses interleukin-1?-induced degeneration of chondrocytes isolated from patients with osteoarthritis through the SIRT1/AMPK/PGC-1? signaling pathway.
Heparan sulfate deficiency leads to hypertrophic chondrocytes by increasing bone morphogenetic protein signaling.
Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments.
Hyaluronan inhibits matrix metalloproteinase-13 in human arthritic chondrocytes via CD44 and P38.
Hyaluronan Suppresses IL-1beta-induced Metalloproteinase Activity from Synovial Tissue.
Hyaluronan suppresses IL-1beta-induced metalloproteinase activity from synovial tissue.
Immobilization of matrix metalloproteinase 8 (MMP-8) for online drug screening.
Increased expression of extracellular matrix metalloproteinase inducer in rheumatoid synovium.
Induction of Matrix Metalloproteinase Expression by Synovial Wnt Signaling and Association With Disease Progression in Early Symptomatic Osteoarthritis.
Induction of matrix metalloproteinase-8 in human fibroblasts by basic calcium phosphate and calcium pyrophosphate dihydrate crystals: effect of phosphocitrate.
Induction of osteoarthritis in the rat by surgical tear of the meniscus: Inhibition of joint damage by a matrix metalloproteinase inhibitor.
Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage.
Inhibitory effects of EGb761 on the expression of matrix metalloproteinases (MMPs) and cartilage matrix destruction.
Intact pericellular matrix of articular cartilage is required for unactivated discoidin domain receptor 2 in the mouse model.
Interferonregulatoryfactor-8(IRF-8) regulates the expression of matrix metalloproteinase-13 (MMP-13) in chondrocytes.
Interleukin-1beta induced activation of nuclear factor-kappab can be inhibited by novel pharmacological agents in osteoarthritis.
Intra-articular lentivirus-mediated insertion of the fat-1 gene ameliorates osteoarthritis.
Leptin enhances MMP-1, MMP-3 and MMP-13 production in human osteoarthritic cartilage and correlates with MMP-1 and MMP-3 in synovial fluid from OA patients.
Lipooxygenase inhibition in osteoarthritis: a potential symptomatic and disease modifying effect?
Matrix metalloproteinase 28/epilysin expression in cartilage from patients with rheumatoid arthritis and osteoarthritis: comment on the article by Kevorkian et al.
Matrix metalloproteinase activity in equine synovial fluid: influence of age, osteoarthritis, and osteochondrosis.
Matrix metalloproteinase and its inhibitor in temporomandibular joint osteoarthrosis after indirect trauma in young goats.
Matrix Metalloproteinase Inhibition With Doxycycline Affects the Progression of Posttraumatic Osteoarthritis After Anterior Cruciate Ligament Rupture: Evaluation in a New Nonsurgical Murine ACL Rupture Model.
Matrix metalloproteinase inhibitors in rheumatic diseases.
Matrix metalloproteinases and inhibitors in cartilage tissue engineering.
Measurement of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in patients with knee osteoarthritis: comparison with generalized osteoarthritis.
Mechanical strain attenuates cytokine-induced ADAMTS9 expression via transient receptor potential vanilloid type 1.
MiRNA-140 is a negative feedback regulator of MMP-13 in IL-1?-stimulated human articular chondrocyte C28/I2 cells.
MMP-3 and -8 expression is found in the condylar surface of temporomandibular joints with internal derangement.
Moderation of iodoacetate-induced experimental osteoarthritis in rats by matrix metalloproteinase inhibitors.
Molecular changes in human osteoarthritic cartilage after 3 weeks of oral administration of BAY 12-9566, a matrix metalloproteinase inhibitor.
NAD(P)H Oxidase Activity of Nox4 in Chondrocytes Is Both Inducible and Involved in Collagenase Expression.
Optimization of matrix metalloproteinase fluorogenic probes for osteoarthritis imaging.
Oral administration of a matrix metalloproteinase inhibitor, CGS 27023A, protects the cartilage proteoglycan matrix in a partial meniscectomy model of osteoarthritis in rabbits.
Osteoarthritic lesions: involvement of three different collagenases.
Osteoblasts Regulate the Expression of ADAMTS and MMPs in Chondrocytes through ERK Signaling Pathway.
Overexpression of HMGB1 A-box reduced IL-1?-induced MMP expression and the production of inflammatory mediators in human chondrocytes.
Plain radiography as an outcome measure in clinical trials involving patients with knee osteoarthritis.
Platelets Contribute to the Accumulation of Matrix Metalloproteinase Type 2 in Synovial Fluid in Osteoarthritis.
Polysaccharide from Angelica sinensis protects chondrocytes from H2O2-induced apoptosis through its antioxidant effects in vitro.
Potent and selective 2-naphthylsulfonamide substituted hydroxamic acid inhibitors of matrix metalloproteinase-13.
Prospects for treating osteoarthritis: enzyme-protein interactions regulating matrix metalloproteinase activity.
Prostaglandin EP2 receptor signalling inhibits the expression of matrix metalloproteinase 13 in human osteoarthritic chondrocytes.
Protective Effect of Withania somnifera and Cardiospermum halicacabum Extracts Against Collagenolytic Degradation of Collagen.
Pyrrolidine dithiocarbamate, a NF-kappaB inhibitor, upregulates MMP-1 and MMP-13 in IL-1beta-stimulated rheumatoid arthritis fibroblast-like synoviocytes.
Quantitative pre-clinical screening of therapeutics for joint diseases using contrast enhanced micro-computed tomography.
Rac1 is required for matrix metalloproteinase-13 production by chondrocytes in response to fibronectin fragments.
Randomized controlled studies on the efficacy of antiarthritic agents in inhibiting cartilage degeneration and pain associated with progression of osteoarthritis in the rat.
Relationship Between Magnetic Resonance T2-Mapping and Matrix Metalloproteinase 1,3 in Knee Osteoarthritis.
Role of PPAR? in down-regulating AGE-induced TGF-? and MMP-9 expressions in chondrocytes.
S100A4 is expressed at site of invasion in rheumatoid arthritis synovium and modulates production of matrix metalloproteinases.
Simvastatin, an HMG-CoA reductase inhibitor, reduced the expression of matrix metalloproteinase-9 (Gelatinase B) in osteoblastic cells and HT1080 fibrosarcoma cells.
Standardized butanol fraction of WIN-34B suppresses cartilage destruction via inhibited production of matrix metalloproteinase and inflammatory mediator in osteoarthritis human cartilage explants culture and chondrocytes.
Synovial matrix metalloproteinase-2 in different stages of sheep temporomandibular joint osteoarthrosis.
Synthesis and structure-activity relationship of alpha-sulfonylhydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis.
Synthesis and structure-activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis.
Targeted designed variants of alpha-2-macroglobulin (A2M) attenuate cartilage degeneration in a rat model of osteoarthritis induced by anterior cruciate ligament transection.
Tetracycline use in treating osteoarthritis: a systematic review.
The effect of non-steroidal anti-inflammatory drugs on matrix metalloproteinases levels in patients with osteoarthritis.
The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants.
The NAD-Dependent Deacetylase Sirtuin-1 Regulates the Expression of Osteogenic Transcriptional Activator Runt-Related Transcription Factor 2 (Runx2) and Production of Matrix Metalloproteinase (MMP)-13 in Chondrocytes in Osteoarthritis.
Thymoquinone inhibits matrix metalloproteinase expression in rabbit chondrocytes and cartilage in experimental osteoarthritis.
TNF-? increases the expression of inflammatory factors in synovial fibroblasts by inhibiting the PI3K/AKT pathway in a rat model of monosodium iodoacetate-induced osteoarthritis.
Transcriptional activation of human MMP-13 gene expression by c-Maf in osteoarthritic chondrocyte.
Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors.
Up-regulated DERL3 in fibroblast-like synoviocytes exacerbates inflammation of rheumatoid arthritis.
[Effect of acupotomy lysis on serum matrix metalloproteinase (MMP)-3 and MMP-13 contents in osteoarthritis rabbits]
[Effects of intra-articular injection of p38 mitogen-activated protein kinase inhibitor on matrix metalloproteinase in articular cartilage of a rat model of osteoarthritis]
Osteoarthritis, Knee
Associations between knee structural measures, circulating inflammatory factors and MMP13 in patients with knee osteoarthritis.
Development of musculoskeletal toxicity without clear benefit after administration of PG 116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12 month, double-blind, placebo-controlled study.
Effects of Exercise Training Alone and in Combination With Kinesio Taping on Pain, Functionality, and Biomarkers Related to the Cartilage Metabolism in Knee Osteoarthritis.
Effects of l-Carnitine Supplementation on Serum Inflammatory Factors and Matrix Metalloproteinase Enzymes in Females with Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Pilot Study.
Increased serum ADAMTS-4 in knee osteoarthritis: a potential indicator for the diagnosis of osteoarthritis in early stages.
Measurement of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in patients with knee osteoarthritis: comparison with generalized osteoarthritis.
Plain radiography as an outcome measure in clinical trials involving patients with knee osteoarthritis.
Relationship Between Magnetic Resonance T2-Mapping and Matrix Metalloproteinase 1,3 in Knee Osteoarthritis.
Serum levels of matrix metalloproteinase-3 as a prognostic marker for progression of cartilage injury in patients with knee osteoarthritis.
Osteochondritis Dissecans
Microscopic localization of active gelatinases in equine osteochondritis dissecans (OCD) cartilage.
Osteochondrodysplasias
Differential expression of extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) in avian tibial dyschondroplasia.
Matrix metalloproteinase activities in avian tibial dyschondroplasia.
Osteochondrosis
Matrix metalloproteinase activity in equine synovial fluid: influence of age, osteoarthritis, and osteochondrosis.
Osteolysis
Characterization of Normal Murine Carpal Bone Development Prompts Re-Evaluation of Pathologic Osteolysis as the Cause of Human Carpal-Tarsal Osteolysis Disorders.
Matrix metalloproteinase (MMP)-13 regulates mammary tumor-induced osteolysis by activating MMP9 and transforming growth factor-beta signaling at the tumor-bone interface.
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in loose artificial hip joints.
Possible role of matrix metalloproteinase in osteolytic intracranial meningiomas.
[Influence and role of expression of extracellular matrix metalloproteinase inducer and matrix metalloproteinase 9 in aseptic loosening of prosthesis].
Osteonecrosis
Association of MMP-8 rs2012390 and rs11225394 polymorphisms with osteonecrosis of the femoral head risks: Evidence from a meta-analysis.
MMP-3 and MMP-8 single-nucleotide polymorphisms are related to alcohol-induced osteonecrosis of the femoral head in Chinese males.
Osteophyte
Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development.
Osteoporosis
Dynamic expression of matrix metalloproteinases 2, 9 and 13 in ovariectomy-induced osteoporosis rats.
Effects of alendronate and hormone replacement therapy, alone and in combination, on saliva, periodontal conditions and gingival crevicular fluid matrix metalloproteinase-8 levels in women with osteoporosis.
EVALUATION OF BONE RESORPTIVE POTENTIAL IN THE TREATMENT OF GENERALIZED PERIODONTITIS.
Immunolocalization of MMP 2, 9 and 13 in prednisolone induced osteoporosis in mice.
Osteosarcoma
Actopaxin (?-Parvin) phosphorylation is required for matrix degradation and cancer cell invasion.
Antagonism of chemokine receptor CXCR3 inhibits osteosarcoma metastasis to lungs.
AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element.
Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells.
Doxorubicin and BAY 12-9566 for the treatment of osteosarcoma in dogs: a randomized, double-blind, placebo-controlled study.
Expression and clinical significance of extracellular matrix metalloproteinase inducer, EMMPRIN/CD147, in human osteosarcoma.
Expression of matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) induced by tumour necrosis factor alpha correlates with metastatic ability in a human osteosarcoma cell line.
Expression of matrix metalloproteinase regulator, RECK, and its clinical significance in osteosarcoma.
Glucosamine sulfate suppresses the expression of matrix metalloproteinase-3 in osteosarcoma cells in vitro.
Inhibition of spontaneous rat osteosarcoma lung metastasis by 3S-[4-(N-hydroxyamino)-2R-isobutylsuccinyl]amino-1-methoxy-3,4-dihydroc arbostyril, a novel matrix metalloproteinase inhibitor.
MicroRNA-2682-3p inhibits osteosarcoma cell proliferation by targeting CCND2, MMP8 and Myd88.
MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), amplified on chromosome 9, collaborate with p53 deficiency in mouse osteosarcoma progression.
Monocyte Chemoattractant Protein-1 promotes cancer cell migration via c-Raf/MAPK/AP-1 pathway and MMP-9 production in osteosarcoma.
Oridonin inhibits the proliferation, migration and invasion of human osteosarcoma cells via suppression of matrix metalloproteinase expression and STAT3 signalling pathway.
Overexpression of matrix metalloproteinase (MMP)-9 correlates with metastatic potency of spontaneous and 4-hydroxyaminoquinoline 1-oxide (4-HAQO)-induced transplantable osteosarcomas in rats.
Phosphorylated c-Jun and Fra-1 induce matrix metalloproteinase-1 and thereby regulate invasion activity of 143B osteosarcoma cells.
Ras activation mediates WISP-1-induced increases in cell motility and matrix metalloproteinase expression in human osteosarcoma.
Reoxygenation using a novel CO2 therapy decreases the metastatic potential of osteosarcoma cells.
S100A7 promotes the migration and invasion of osteosarcoma cells via the receptor for advanced glycation end products.
Stage-IIB osteosarcomas around the knee. A study of MMP-9 in surviving tumour cells.
STK39, overexpressed in osteosarcoma, regulates osteosarcoma cell invasion and proliferation.
Upregulation of miR-328 and inhibition of CREB-DNA-binding activity are critical for resveratrol-mediated suppression of matrix metalloproteinase-2 and subsequent metastatic ability in human osteosarcomas.
VEGF and EMMPRIN expression correlates with survival of patients with osteosarcoma.
Otitis Media
Expression of matrix metalloproteinase in cholesteatoma epithelium of patients with cholesteatoma otitis media.
Matrix metalloproteinase-8/collagenase-2 in childhood otitis media with effusion.
Selected cytokines in hypertrophic adenoids in children suffering from otitis media with effusion.
Otitis Media with Effusion
Matrix metalloproteinase-8/collagenase-2 in childhood otitis media with effusion.
Selected cytokines in hypertrophic adenoids in children suffering from otitis media with effusion.
Ovarian Cysts
Collagenases (MMP-1, -8 and -13) and trypsinogen-2 in fluid from benign and malignant ovarian cysts.
Study on matrix metalloproteinase 1 and 2 gene expression and NO in dairy cows with ovarian cysts.
Ovarian Neoplasms
CD147 in ovarian and other cancers.
Characterization of extracellular matrix-degrading proteinase and its inhibitor in gynecologic cancer tissues with clinically different metastatic form.
Cytokine-regulated expression of collagenase-2 (MMP-8) is involved in the progression of ovarian cancer.
Editor's Note: The Clinical Relevance of Stromal Matrix Metalloproteinase Expression in Ovarian Cancer.
Effect of CO2 pneumoperitoneum on the proliferation of human ovarian cancer cell line SKOV-3 and the expression of NM23-H1 and MMP-2.
EGF-receptor regulation of matrix metalloproteinases in epithelial ovarian carcinoma.
Epidermal growth factor receptor signaling and the invasive phenotype of ovarian carcinoma cells.
Extracellular matrix metalloproteinase inducer (EMMPRIN) expression correlates positively with active angiogenesis and negatively with basic fibroblast growth factor expression in epithelial ovarian cancer.
Fibroblasts stimulate human ovarian cancer cell invasion and expression of 72-kDa gelatinase A (MMP-2).
Fibronectin activates matrix metalloproteinase-9 secretion via the MEK1-MAPK and the PI3K-Akt pathways in ovarian cancer cells.
Functional role of matrix metalloproteinases in ovarian tumor cell plasticity.
Genetic variants in matrix metalloproteinase genes as disposition factors for ovarian cancer risk, survival, and clinical outcome.
Gonadotropin-releasing hormone promotes ovarian cancer cell invasiveness through c-Jun NH2-terminal kinase-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9.
Inactivation of von Hippel-Lindau increases ovarian cancer cell aggressiveness through the HIF1?/miR-210/VMP1 signaling pathway.
Increased expression of matrix metalloproteinases (MMP)-2, MMP-9, and the urokinase-type plasminogen activator is associated with progression from benign to advanced ovarian cancer.
Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration.
Inhibition of integrin ?1 decreases the malignancy of ovarian cancer cells and potentiates anticancer therapy via the FAK/STAT1 signaling pathway.
Inhibition of matrix metalloproteinase-2 secretion and invasion by human ovarian cancer cell line SK-OV-3 with lysine, proline, arginine, ascorbic acid and green tea extract.
Lysophosphatidic acid promotes matrix metalloproteinase (MMP) activation and MMP-dependent invasion in ovarian cancer cells.
Matrix Metalloproteinase Expressions Play Important role in Prediction of Ovarian Cancer Outcome.
Matrix metalloproteinase-8 promoter gene polymorphisms in Mexican women with ovarian cancer.
Mixed lineage kinase 3 is required for matrix metalloproteinase expression and invasion in ovarian cancer cells.
Novel functions for 2-phenylbenzimidazole-5-sulphonic acid: Inhibition of ovarian cancer cell responses and tumour angiogenesis.
Optical imaging of ovarian cancer using a matrix metalloproteinase-3-sensitive near-infrared fluorescent probe.
Oridonin effectively reverses cisplatin drug resistance in human ovarian cancer cells via induction of cell apoptosis and inhibition of matrix metalloproteinase expression.
Ovarian cancers overexpress the antimicrobial protein hCAP-18 and its derivative LL-37 increases ovarian cancer cell proliferation and invasion.
Overexpression of CD147 in ovarian cancer is initiated by the hypoxic microenvironment.
Phosphatidylinositol 3-kinase activity in epidermal growth factor-stimulated matrix metalloproteinase-9 production and cell surface association.
Sorafenib controls the epithelial?mesenchymal transition of ovarian cancer cells via EGF and the CD44?HA signaling pathway in a cell type?dependent manner.
The clinical relevance of stromal matrix metalloproteinase expression in ovarian cancer.
The role of proteolytic enzymes in the pathology of epithelial ovarian carcinoma.
The role of SDF-1/CXCR4 axis in ovarian cancer metastasis.
Tumor-associated macrophages promote invasion via Toll-like receptors signaling in patients with ovarian cancer.
Vacuolar ATPase 'a2' isoform exhibits distinct cell surface accumulation and modulates matrix metalloproteinase activity in ovarian cancer.
Vascular endothelial growth factor activating matrix metalloproteinase in ascitic fluid during peritoneal dissemination of ovarian cancer.
[Association of single nucleotide polymorphism in matrix metalloproteinases promoter with susceptibility to ovarian cancer]
Overnutrition
Postnatal early overnutrition dysregulates the intrarenal renin-angiotensin system and extracellular matrix-linked molecules in juvenile male rats.
Overweight
Association of MMP-8 with obesity, smoking and insulin resistance.
Early pregnancy serum IGFBP-1 relates to lipid profile in overweight and obese women.
Level of Adiponectin, Leptin and Selected Matrix Metalloproteinases in Female Overweight Patients with Primary Gonarthrosis.
Paget Disease, Extramammary
Possible mechanisms of the crosstalk between Langerhans cells and regulatory T cells in extramammary Paget's disease by receptor activator of nuclear factor kappa-B ligand (RANKL)/ RANK pathways.
Pancreatic Neoplasms
?-Mangostin suppresses lipopolysaccharide-induced invasion by inhibiting matrix metalloproteinase-2/9 and increasing E-cadherin expression through extracellular signal-regulated kinase signaling in pancreatic cancer cells.
A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer.
A phase II trial of marimastat in advanced pancreatic cancer.
Addition of matrix metalloproteinase inhibition to conventional cytotoxic therapy reduces tumor implantation and prolongs survival in a murine model of human pancreatic cancer.
Antitumor effect of a new selective matrix metalloproteinase inhibitor, MMI-166, on experimental pancreatic cancer.
Biological approaches to therapy of pancreatic cancer.
Bone morphogenetic proteins induce pancreatic cancer cell invasiveness through a Smad1-dependent mechanism that involves matrix metalloproteinase-2.
Cellular contractility and extracellular matrix stiffness regulate matrix metalloproteinase activity in pancreatic cancer cells.
Characterisation of a novel matrix metalloproteinase inhibitor on pancreatic adenocarcinoma cells in vitro and in an orthotopic pancreatic cancer model in vivo.
Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group.
Comprehensive analysis of matrix metalloproteinase and tissue inhibitor expression in pancreatic cancer: increased expression of matrix metalloproteinase-7 predicts poor survival.
Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products.
Detection of matrix metalloproteinase activity in human pancreatic cancer.
Effect of matrix metalloproteinase inhibition on pancreatic cancer invasion and metastasis: an additive strategy for cancer control.
Effects of 5-aza-2'-deoxycytidine on matrix metalloproteinase expression and pancreatic cancer cell invasiveness.
Elevated systemic levels of the matrix metalloproteinase inhibitor TIMP-1 correlate with clinical markers of cachexia in patients with chronic pancreatitis and pancreatic cancer.
Evaluation of vascular endothelial growth factor blockade and matrix metalloproteinase inhibition as a combination therapy for experimental human pancreatic cancer.
Expression of extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) in pancreatic neoplasm and pancreatic stellate cells.
Extracelluar matrix metalloproteinase as a novel target for pancreatic cancer therapy.
Gamma-Irradiation Enhances RECK Protein Levels in Panc-1 Pancreatic Cancer Cells.
Gli1 contributes to the invasiveness of pancreatic cancer through matrix metalloproteinase-9 activation.
High expression of MMP28 indicates unfavorable prognosis in pancreatic cancer.
In vitro and in vivo matrix metalloproteinase production by pancreatic cancer cells and by distant organs.
Luteolin decreases invasiveness, deactivates STAT3 signaling, and reverses interleukin-6 induced epithelial-mesenchymal transition and matrix metalloproteinase secretion of pancreatic cancer cells.
Matrix metalloproteinase (MMP) inhibition selectively decreases type II MMP activity in a murine model of pancreatic cancer.
Matrix metalloproteinase inhibition attenuates human pancreatic cancer growth in vitro and decreases mortality and tumorigenesis in vivo.
Matrix metalloproteinase inhibition improves survival in an orthotopic model of human pancreatic cancer.
Matrix metalloproteinase inhibition of pancreatic cancer: matching mechanism of action to clinical trial design.
Matrix metalloproteinase inhibitor RO 28-2653 decreases liver metastasis by reduction of MMP-2 and MMP-9 concentration in BOP-induced ductal pancreatic cancer in Syrian Hamsters: inhibition of matrix metalloproteinases in pancreatic cancer.
MMI-166, a selective matrix metalloproteinase inhibitor, promotes apoptosis in human pancreatic cancer.
Modification and Biological Evaluation of a Series of 1,5-Diaryl-1,2,4-triazole Compounds as Novel Agents against Pancreatic Cancer Metastasis through Targeting Myoferlin.
Neurotransmitter Substance P Mediates Pancreatic Cancer Perineural Invasion via NK-1R in Cancer Cells.
New target therapies in advanced pancreatic cancer.
Novel approaches to target pancreatic cancer.
Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo.
Overexpression of membrane-type 2 matrix metalloproteinase induced by hypoxia-inducible factor-1? in pancreatic cancer: Implications for tumor progression and prognosis.
Pancreatic cancer: what the oncologist can offer for palliation.
Pancreaticobiliary cancer: the future aspects of medical oncology.
Peroxisome proliferator-activated receptor gamma ligand inhibits cell growth and invasion of human pancreatic cancer cells.
Prevention of early liver metastasis after pancreatectomy by perioperative administration of a nuclear factor-?B inhibitor in mice.
Profile of MMP and TIMP Expression in Human Pancreatic Stellate Cells: Regulation by IL-1? and TGF? and Implications for Migration of Pancreatic Cancer Cells.
Radiation-induced increase in invasive potential of human pancreatic cancer cells and its blockade by a matrix metalloproteinase inhibitor, CGS27023.
Role of matrix metalloproteinases and their inhibitors in pancreatic cancer.
Rosmarinic inhibits cell proliferation, invasion and migration via up-regulating miR-506 and suppressing MMP2/16 expression in pancreatic cancer.
Significance of combination therapy of zoledronic acid and gemcitabine on pancreatic cancer.
Stromal metalloproteinase-9 is essential to angiogenesis and progressive growth of orthotopic human pancreatic cancer in parabiont nude mice.
The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer.
Thrombospondin-2 inhibits tumor cell invasion through the modulation of MMP-9 and uPA in pancreatic cancer cells.
Pancreatitis
Activated matrix metalloproteinase 8 in serum predicts severity of acute pancreatitis.
Associations of MMP-2 and MMP-9 gene polymorphism with ulinastatin efficacy in patients with severe acute pancreatitis.
Increased matrix metalloproteinase expression and activation following experimental acute pancreatitis.
Inhibition of Matrix Metalloproteinase with BB-94 Protects against Caerulein-Induced Pancreatitis via Modulating Neutrophil and Macrophage Activation.
Matrix metalloproteinase levels in acute aortic dissection, acute pancreatitis and other abdominal pain.
Role of TGF-beta1, extracellular matrix, and matrix metalloproteinase in the healing process of the pancreas after induction of acute necrotizing pancreatitis using arginine in rats.
Pancreatitis, Acute Necrotizing
Role of TGF-beta1, extracellular matrix, and matrix metalloproteinase in the healing process of the pancreas after induction of acute necrotizing pancreatitis using arginine in rats.
Pancreatitis, Chronic
Elevated systemic levels of the matrix metalloproteinase inhibitor TIMP-1 correlate with clinical markers of cachexia in patients with chronic pancreatitis and pancreatic cancer.
Role of matrix metalloproteinase 3 gene promoter polymorphism in chronic pancreatitis.
Papilloma
Increased expression of matrix metalloproteinase-2 and 9 and human papilloma virus infection are associated with malignant transformation of sinonasal inverted papilloma.
Influence of beta1 integrins on epidermal squamous cell carcinoma formation in a transgenic mouse model: alpha3beta1, but not alpha2beta1, suppresses malignant conversion.
Serum matrix metalloproteinase 8 and tissue inhibitor of metalloproteinase 1: Potential markers for malignant transformation of recurrent respiratory papillomatosis and for prognosis of laryngeal cancer.
Papilloma, Inverted
Increased expression of matrix metalloproteinase-2 and 9 and human papilloma virus infection are associated with malignant transformation of sinonasal inverted papilloma.
Papillomavirus Infections
Markers of squamocolumnar junction cells in normal tonsils and oropharyngeal cancer with and without HPV infection.
Persistent Oral Human Papillomavirus (HPV) Infection is Associated with Low Salivary Levels of Matrix Metalloproteinase 8 (MMP-8).
Paralysis
Localization of near-infrared labeled antibodies to the central nervous system in experimental autoimmune encephalomyelitis.
Mitochondrial dysfunction causes Ca2+ overload and ECM degradation-mediated muscle damage in C. elegans.
Paraparesis, Tropical Spastic
Selective matrix metalloproteinase inhibitor, N-biphenyl sulfonyl phenylalanine hydroxamic acid, inhibits the migration of CD4+ T lymphocytes in patients with HTLV-I-associated myelopathy.
Parasitic Diseases
Ecological Factors Mediate Immunity and Parasitic Co-Infection in Sea Fan Octocorals.
Parathyroid Neoplasms
Expression of matrix metalloproteinase gelatinase A messenger ribonucleic acid in parathyroid carcinomas.
Parkinson Disease
Exploring the Association Between Rosacea and Parkinson Disease: A Danish Nationwide Cohort Study.
Matrix Metalloproteinase-8 Inhibitor Ameliorates Inflammatory Responses and Behavioral Deficits in LRRK2 G2019S Parkinson's Disease Model Mice.
Suppression of neuroinflammation by matrix metalloproteinase-8 inhibitor in aged normal and LRRK2 G2019S Parkinson's disease model mice challenged with lipopolysaccharide.
Parotitis
Decreased salivary matrix metalloproteinase-8 reflecting a defensive potential in juvenile parotitis.
Pediatric Obesity
Assessment of matrix metalloproteinase (MMP)-2, MMP-8, MMP-9, and their inhibitors, the tissue inhibitors of metalloproteinase (TIMP)-1 and TIMP-2 in obese children and adolescents.
Pemphigoid, Benign Mucous Membrane
Neutrophil Collagenase, Gelatinase, and Myeloperoxidase in Tears of Patients with Stevens-Johnson Syndrome and Ocular Cicatricial Pemphigoid.
Pemphigoid, Bullous
Limbal Fibroblasts Maintain Normal Phenotype in 3D RAFT Tissue Equivalents Suggesting Potential for Safe Clinical Use in Treatment of Ocular Surface Failure.
Profibrotic phenotype of conjunctival fibroblasts from mucous membrane pemphigoid.
Respective contribution of neutrophil elastase and matrix metalloproteinase 9 in the degradation of BP180 (type XVII collagen) in human bullous pemphigoid.
Penile Induration
Differential calcium independent regulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases by interleukin-1beta and transforming growth factor-beta in Peyronie's plaque fibroblasts.
Fibroproliferative disorders and diabetes: Understanding the pathophysiologic relationship between Peyronie's disease, Dupuytren disease and diabetes.
Peptic Ulcer
Functionally significant polymorphisms of the MMP-9 gene are associated with peptic ulcer disease in the Caucasian population of Central Russia.
Peri-Implantitis
aMMP-8 Point-of-Care/Chairside Oral Fluid Technology as a Rapid, Non-Invasive Tool for Periodontitis and Peri-Implantitis Screening in a Medical Care Setting.
An Unexplored Pharmacologic/Diagnostic Strategy for Peri-Implantitis: A Protocol Proposal.
Analysis of matrix metalloproteinases, especially MMP-8, in gingival creviclular fluid, mouthrinse and saliva for monitoring periodontal diseases.
Assessment of matrix metalloproteinase-8 and -9 levels in the peri-implant sulcular fluid among waterpipe (narghile) smokers and never-smokers with peri-implantitis.
Biomarker levels in peri-implant crevicular fluid of healthy implants, untreated and non-surgically treated implants with peri-implantitis.
Characteristics of collagenase-2 from gingival crevicular fluid and peri-implant sulcular fluid in periodontitis and peri-implantitis patients: pilot study.
Collagenase-2 (MMP-8) as a point-of-care biomarker in periodontitis and cardiovascular diseases. Therapeutic response to non-antimicrobial properties of tetracyclines.
Cytokine and matrix metalloproteinase expression in fibroblasts from peri-implantitis lesions in response to viable Porphyromonas gingivalis.
Early intervention of peri-implantitis and periodontitis utilizing a mouse model.
Evaluation of Metalloproteinase-8 Levels in Crevicular Fluid of Patients with Healthy Implants or Periodontitis.
Histological evaluation of peri-implant mucosal and gingival tissues in peri-implantitis, peri-implant mucositis and periodontitis patients: a cross-sectional clinical study.
Host-Modulation Therapy and Chair-Side Diagnostics in the Treatment of Peri-Implantitis.
Laminin-5 gamma2-chain and collagenase-2 (MMP-8) in human peri-implant sulcular fluid.
Levels and molecular forms of MMP-7 (matrilysin-1) and MMP-8 (collagenase-2) in diseased human peri-implant sulcular fluid.
Matrix Metalloproteinase-8 as an Inflammatory and Prevention Biomarker in Periodontal and Peri-Implant Diseases.
Matrix metalloproteinase-8 is the major potential collagenase in active peri-implantitis.
Matrix metalloproteinase-8 levels in peri-implant sulcus fluid adjacent to titanium and zirconium nitride surfaces.
Matrix metalloproteinases (MMPs) in oral diseases.
MMP-8-Responsive Polyethylene Glycol Hydrogel for Intraoral Drug Delivery.
Peri-Implant Sulcus Fluid (PISF) Matrix Metalloproteinase (MMP) -8 Levels in Peri-Implantitis.
Periodontitis and peri-implantitis tissue levels of Treponema denticola-CTLP and its MMP-8 activating ability.
Salivary Diagnostics-Point-of-Care diagnostics of MMP-8 in dentistry and medicine.
Scientific basis of a matrix metalloproteinase-8 specific chair-side test for monitoring periodontal and peri-implant health and disease.
Tissue inhibitor of metalloproteinases-1, matrix metalloproteinases-1 and -8, and collagenase activity levels in peri-implant crevicular fluid after implantation.
Use of IL-1 ?, IL-6, TNF-?, and MMP-8 biomarkers to distinguish peri-implant diseases: A systematic review and meta-analysis.
Periapical Diseases
Sonic extracts from a bacterium related to periapical disease activate gelatinase A and inactivate tissue inhibitor of metalloproteinases TIMP-1 and TIMP-2.
Periapical Granuloma
Expression and induction of collagenases (MMP-8 and -13) in plasma cells associated with bone-destructive lesions.
Expression of matrix metalloproteinase-8 and matrix metalloproteinase-13 in mast cells of human periapical lesions.
High matrix metalloproteinase activity is a hallmark of periapical granulomas.
Matrix metalloproteinase-8 (MMP-8) in pulpal and periapical inflammation and periapical root-canal exudates.
Periapical Periodontitis
Clinical Investigation of Matrix Metalloproteinases, Tissue Inhibitors of Matrix Metalloproteinases, and Matrix Metalloproteinase/Tissue Inhibitors of Matrix Metalloproteinase Complexes and Their Networks in Apical Periodontitis.
Expression Levels of Matrix Metalloproteinase-9 and Gram-negative Bacteria in Symptomatic and Asymptomatic Periapical Lesions.
Expression of Interleukin-1? and Matrix Metalloproteinase-8 in Cytolytic and Noncytolytic Enterococcus faecalis-induced Persistent Apical Periodontitis: A Comparative Study in the Rat.
Expression of matrix metalloproteinase-8 and matrix metalloproteinase-13 in mast cells of human periapical lesions.
Expression of Matrix Metalloproteinases and Tissue Inhibitor of Matrix Metalloproteinases during Apical Periodontitis Development.
Matrix metalloproteinase expression in teeth with apical periodontitis is differentially modulated by the modality of root canal treatment.
The Expression of Semaphorin 7A in Human Periapical Lesions.
Pericardial Effusion
Lesions of the pericardium and their significance in the aetiology of heart failure in broiler chickens.
Perinatal Death
Gastric fluid versus amniotic fluid analysis for the identification of intra-amniotic infection due to Ureaplasma species.
Periodontal Attachment Loss
Association of gingival crevicular fluid biomarkers during periodontal maintenance with subsequent progressive periodontitis.
Collagenolytic enzymes in gingival crevicular fluid as diagnostic indicators of periodontitis.
Periodontal Diseases
A novel chemically modified curcumin reduces inflammation-mediated connective tissue breakdown in a rat model of diabetes: periodontal and systemic effects.
A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 8 (neutrophil collagenase) using monoclonal antibodies.
A Prototype Antibody-based Biosensor for Measurement of Salivary MMP-8 in Periodontitis using Surface Acoustic Wave Technology.
Analysis of matrix metalloproteinases, especially MMP-8, in gingival creviclular fluid, mouthrinse and saliva for monitoring periodontal diseases.
Anti-rheumatic medication and salivary MMP-8, a biomarker for periodontal disease.
Application of quantitative proteomic analysis using tandem mass tags for discovery and identification of novel biomarkers in periodontal disease.
Areca nut extract represses migration and differentiation while activating matrix metalloproteinase-9 of normal gingival epithelial cells.
Assessment of a novel screening test for neutrophil collagenase activity in the diagnosis of periodontal diseases.
Association between isotretinoin (Roaccutanne) use and changes in periodontal clinical parameters and MMP-8 and MMP-9 salivary levels.
Association between serum and oral matrix metalloproteinase-8 levels and periodontal health status.
Associations of oral fluid MMP-8 with periodontitis in Swiss adult subjects.
Biomarkers of periodontitis in oral fluids.
Changes in Inflammatory Cytokines in Saliva after Non-Surgical Periodontal Therapy: A Systematic Review and Meta-Analysis.
Circulating matrix metalloproteinase-8 (MMP-8) and MMP-9 are increased in chronic periodontal disease and decrease after non-surgical periodontal therapy.
Circulating Porphyromonas gingivalis lipopolysaccharide resets cardiac homeostasis in mice through a matrix metalloproteinase-9-dependent mechanism.
Clinical trials of a matrix metalloproteinase inhibitor in human periodontal disease. SDD Clinical Research Team.
Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3).
Diagnostic sensitivity and specificity of host-derived salivary biomarkers in periodontal disease amongst adults: Systematic review.
Differential regulation of MMP-13 by chemical modified tetracyclines in osteoblasts.
Effect of smoking on periodontal health.
Effect of systemic matrix metalloproteinase inhibition on periodontal wound repair: a proof of concept trial.
Effects of Cigarette Smoke Condensate and Nicotine on Human Gingival Fibroblast-Mediated Collagen Degradation.
Effects of therapy with two combinations of antibiotics on the imbalance of MMP-2÷TIMP-2 in chronic periodontitis.
Epithelial barrier and oral bacterial infection.
Evaluation of active matrix metalloproteinase-8 (aMMP-8) chair-side test as a diagnostic biomarker in the staging of periodontal diseases.
Evaluation of gingival crevicular fluid cyclophilin a and extracellular matrix metalloproteinase inducer levels in different periodontal diseases.
Evaluation of immunoassay-based MMP-8 detection in gingival crevicular fluid on a point-of-care platform.
Evaluation of salivary biomarkers for the diagnosis of periodontitis.
Functional polymorphisms in the matrix metalloproteinase-9 gene in relation to severity of chronic periodontitis.
Gingival crevicular fluid matrix metalloproteinase (MMP)-7, extracellular MMP inducer, and tissue inhibitor of MMP-1 levels in periodontal disease.
Gingival crevicular fluid MMP-8 and -13 and TIMP-1 levels in patients with rheumatoid arthritis and inflammatory periodontal disease.
Gingival crevicular fluid semaphorin 4D and peptidylarginine deiminase-2 levels in periodontal health and disease.
Identification of pathogen and host-response markers correlated with periodontal disease.
Identification of polymorphonuclear leukocyte collagenase and gelatinase activities in mouthrinse samples: correlation with periodontal disease activity in adult and juvenile periodontitis.
Increased local matrix metalloproteinase-8 expression in the periodontal connective tissues of smokers with periodontal disease.
Inhibition of alveolar bone loss by matrix metalloproteinase inhibitors in experimental periodontal disease.
Inhibitory effect of flavonoid baicalin on degranulation of human polymorphonuclear leukocytes induced by interleukin-8: potential role in periodontal diseases.
Levels of gingival crevicular metalloproteinases-8 and -9 in periodontitis.
Longitudinal analysis of metalloproteinases, tissue inhibitors of metalloproteinases and clinical parameters in gingival crevicular fluid from periodontitis-affected patients.
Matrix metalloproteinase 8 (MMP8) gene polymorphisms in chronic periodontitis.
Matrix metalloproteinase-8 activity in gingival crevicular fluid: development of a novel assay.
Matrix metalloproteinase-8 analysis in patients with periodontal disease with prediabetes or type 2 diabetes mellitus: A systematic review.
Matrix metalloproteinase-8 concentration in shallow crevices associated with the extent of periodontal disease.
Matrix metalloproteinase-8 expression in periodontal tissues surgically removed from diabetic and non-diabetic patients with periodontal disease.
Matrix metalloproteinase-8 levels in periodontal disease patients: A systematic review.
Matrix metalloproteinases-1 and -8 and TIMP-1 mRNA levels in normal and diseased human gingivae.
Microfluidic immunoassays as rapid saliva-based clinical diagnostics.
MMP-8, TRAP-5, and OPG Levels in GCF Diagnostic Potential to Discriminate between Healthy Patients', Mild and Severe Periodontitis Sites.
Monitoring periodontal disease status in smokers and nonsmokers using a gingival crevicular fluid matrix metalloproteinase-8-specific chair-side test.
Neutrophil elastase activity, levels of prostaglandin E2, and matrix metalloproteinase-8 in refractory periodontitis sites in smokers and non-smokers.
Non-proteolytic activation of latent human neutrophil collagenase and its role in matrix destruction in periodontal diseases.
Peri-Implantitis Diagnosis and Prognosis Using Biomarkers in Peri-Implant Crevicular Fluid: A Narrative Review.
Perioceutics: Matrix metalloproteinase inhibitors as an adjunctive therapy for inflammatory periodontal disease.
Periodontal Disease and Adverse Pregnancy Outcomes: A Prospective Study in a Low-Risk Population.
Porphyromonas gingivalis-mediated shedding of extracellular matrix metalloproteinase inducer (EMMPRIN) by oral epithelial cells: a potential role in inflammatory periodontal disease.
Pre-exposure to high glucose augments lipopolysaccharide-stimulated matrix metalloproteinase-1 expression by human U937 histiocytes.
Prediabetes/Diabetes Can Be Screened at the Dental Office by a Low-Cost and Fast Chair-Side/Point-of-Care aMMP-8 Immunotest.
Rapid assessment of salivary MMP-8 and periodontal disease using lateral flow immunoassay.
Relationship between TNF-?, MMP-8, and MMP-9 levels in gingival crevicular fluid and the subgingival microbiota in periodontal disease.
Rheumatoid arthritis and salivary biomarkers of periodontal disease.
Salivary biomarkers of existing periodontal disease: a cross-sectional study.
Salivary biomarkers: Relationship between oxidative stress and alveolar bone loss in chronic periodontitis.
Salivary IgA, Interleukin-1? and MMP-8 as Salivary Biomarkers in Chronic Periodontitis Patients.
Salivary matrix metalloproteinase (MMP-8) levels and gelatinase (MMP-9) activities in patients with type 2 diabetes mellitus.
Salivary Matrix Metalloproteinase-8 and -9 and Myeloperoxidase in Relation to Coronary Heart and Periodontal Diseases: A Subgroup Report from the PAROKRANK Study (Periodontitis and Its Relation to Coronary Artery Disease).
Salivary matrix metalloproteinase-8 in patients with and without coronary heart disease may indicate an increased susceptibility to periodontal disease.
Simvastatin suppresses LPS-induced MMP-1 expression in U937 mononuclear cells by inhibiting protein isoprenylation-mediated ERK activation.
Study of the participation of MMP-7, EMMPRIN and cyclophilin A in the pathogenesis of periodontal disease.
The analysis of matrix metalloproteinase-8 in gingival crevicular fluid and periodontal diseases.
The effects of periodontal therapy on gingival crevicular fluid matrix metalloproteinase-8, interleukin-6 and prostaglandin E2 levels in patients with rheumatoid arthritis.
The influence of type 2 diabetes mellitus on salivary matrix metalloproteinase-8 levels and periodontal parameters: A study in an Indian population.
The influence of type I diabetes mellitus on the expression and activity of gelatinases (matrix metalloproteinases-2 and -9) in induced periodontal disease.
Use of a fluorogenic septapeptide matrix metalloproteinase assay to assess responses to periodontal treatment.
[Purification of human neutrophil collagenase, establishment of its monoclonal antibodies and application to gingival crevicular neutrophils]
Periodontal Pocket
Chlamydia pneumoniae together with collagenase-2 (MMP-8) in periodontal lesions.
Clinical Correlates of A Lateral Flow Immunoassay Oral Risk Indicator.
Collagenase activity in gingival crevicular fluid of patients with juvenile periodontitis.
Is the progression rate of periodontitis related to subgingival biofilm composition or gingival crevicular fluid IL-1? and MMP-8 concentrations?
Origin of MMP-8 and Lactoferrin levels from gingival crevicular fluid, salivary glands and whole saliva.
Periodontal Inflammatory Burden and Salivary Matrix Metalloproteinase-8 Concentration Among Patients With Chronic Kidney Disease at the Predialysis Stage.
Relationship of collagenase and cathepsin G activity in gingival crevicular fluid.
Salivary MMP-8, TIMP-1, and ICTP as markers of advanced periodontitis.
The potential of salivary biomarkers for predicting the sensitivity and monitoring the response to nonsurgical periodontal therapy: A preliminary assessment.
Periodontitis
A novel chemically modified curcumin reduces inflammation-mediated connective tissue breakdown in a rat model of diabetes: periodontal and systemic effects.
A Prototype Antibody-based Biosensor for Measurement of Salivary MMP-8 in Periodontitis using Surface Acoustic Wave Technology.
A Systems Biology Approach to Reveal Putative Host-Derived Biomarkers of Periodontitis by Network Topology Characterization of MMP-REDOX/NO and Apoptosis Integrated Pathways.
Activation of neutrophil collagenase in periodontitis.
Active Matrix Metalloproteinase-8 Point-of-Care (PoC)/Chairside Mouthrinse Test vs. Bleeding on Probing in Diagnosing Subclinical Periodontitis in Adolescents.
Active MMP-8 (aMMP-8) as a Grading and Staging Biomarker in the Periodontitis Classification.
Active MMP-8 Quantitative Test as an Adjunctive Tool for Early Diagnosis of Periodontitis.
aMMP-8 Point-of-Care/Chairside Oral Fluid Technology as a Rapid, Non-Invasive Tool for Periodontitis and Peri-Implantitis Screening in a Medical Care Setting.
An aMMP-8 Point-of-Care and Questionnaire Based Real-Time Diagnostic Toolkit for Medical Practitioners.
An Unexplored Pharmacologic/Diagnostic Strategy for Peri-Implantitis: A Protocol Proposal.
Analysis of matrix metalloproteinase (MMP-8 and MMP-2) activity in gingival crevicular fluid from children with Down's syndrome.
Analysis of matrix metalloproteinases, especially MMP-8, in gingival creviclular fluid, mouthrinse and saliva for monitoring periodontal diseases.
Assessment of a novel screening test for neutrophil collagenase activity in the diagnosis of periodontal diseases.
Assessment of MMP-1, MMP-8 and TIMP-2 in experimental periodontitis treated with kaempferol.
Association between isotretinoin (Roaccutanne) use and changes in periodontal clinical parameters and MMP-8 and MMP-9 salivary levels.
Association between serum and oral matrix metalloproteinase-8 levels and periodontal health status.
Association of Common Variants in MMPs with Periodontitis Risk.
Associations between matrix metalloproteinase-8 and -14 and myeloperoxidase in gingival crevicular fluid from subjects with progressive chronic periodontitis: a longitudinal study.
Associations of oral fluid MMP-8 with periodontitis in Swiss adult subjects.
Associations of periodontal microorganisms with salivary proteins and MMP-8 in gingival crevicular fluid.
Biomarkers of periodontitis in oral fluids.
Bisphosfonate matrix metalloproteinase inhibitors for the treatment of periodontitis: An in vitro study.
Changes in Inflammatory Cytokines in Saliva after Non-Surgical Periodontal Therapy: A Systematic Review and Meta-Analysis.
Characteristics of collagenase-2 from gingival crevicular fluid and peri-implant sulcular fluid in periodontitis and peri-implantitis patients: pilot study.
Clinical Correlates of A Lateral Flow Immunoassay Oral Risk Indicator.
Collagenase-2 (MMP-8) and collagenase-3 (MMP-13) in adult periodontitis: molecular forms and levels in gingival crevicular fluid and immunolocalisation in gingival tissue.
Collagenase-2 (MMP-8) as a point-of-care biomarker in periodontitis and cardiovascular diseases. Therapeutic response to non-antimicrobial properties of tetracyclines.
Comparing periodontitis biomarkers in saliva, oral rinse and gingival crevicular fluid: A pilot study.
Concentration of MMP-8 and IL-1? in gingival crevicular fluid in patients with chronic and aggressive periodontitis.
Content of matrix metalloproteinase-8 and matrix metalloproteinase-9 in oral fluid of patients with chronic generalized periodontitis.
Core-Shell poly-(D,l-Lactide-co-Glycolide)-chitosan Nanospheres with simvastatin-doxycycline for periodontal and osseous repair.
Cross-sectional analysis of risk factors for subclinical periodontitis; active matrix metalloproteinase-8 as a potential indicator in initial periodontitis in adolescents.
Cytokine-induced endogenous procollagenase stored in the extracellular matrix of soft connective tissue results in a burst of collagen breakdown following its activation.
Detection of gingival crevicular fluid MMP-8 levels with different laboratory and chair-side methods.
Diagnostic Ability of Salivary Matrix Metalloproteinase-9 Lateral-Flow-Test Point-of-Care Test for Periodontitis.
Diagnostic accuracy of a point-of-care aMMP-8 test in the discrimination of periodontal health and disease.
Diagnostic and Prognostic ability of salivary MMP-9 and S100A8 for periodontitis.
Diagnostic sensitivity and specificity of host-derived salivary biomarkers in periodontal disease amongst adults: Systematic review.
Does Chemically Modified Curcumin Control the Progression of Periodontitis? A Systematic Review.
Early intervention of peri-implantitis and periodontitis utilizing a mouse model.
Early pregnancy levels of gingival crevicular fluid matrix metalloproteinases-8 and -9 are associated with the severity of periodontitis and the development of gestational diabetes mellitus.
Efficacy test of horse chestnut leaf extract (ALH-L1005) as matrix metalloproteinase inhibitors in ligature-induced periodontitis in canine model.
EMMPRIN-CypA contributes to the inflammatory processes in human periodontitis through infiltrating CD68+ inflammatory cells.
EVALUATION OF BONE RESORPTIVE POTENTIAL IN THE TREATMENT OF GENERALIZED PERIODONTITIS.
Evaluation of Metalloproteinase-8 Levels in Crevicular Fluid of Patients with Healthy Implants or Periodontitis.
Evaluation of salivary biomarkers for the diagnosis of periodontitis.
Evidence of a direct relationship between neutrophil collagenase activity and periodontal tissue destruction in vivo: role of active enzyme in human periodontitis.
Expression of mRNA for matrix metalloproteinases and tissue inhibitors of metalloproteinases in periodontitis-affected human gingival tissue.
Expression profile of lipoxygenases in gingival tissues of human periodontitis.
Extracellular ?-NAD(+) Inhibits Interleukin-1-Induced Matrix Metalloproteinase-1 and -3 Expression on Human Gingival Fibroblasts.
Full-mouth profile of active MMP-8 in periodontitis patients.
Genetic Factors and the Risk of Periodontitis Development: Findings from a Systematic Review Composed of 13 Studies of Meta-Analysis with 71,531 Participants.
Gingival crevicular fluid collagenase-2 (MMP-8) test stick for chair-side monitoring of periodontitis.
Gingival crevicular fluid levels of matrix metalloproteinases cross-sectionally related to periodontitis and metabolic syndrome in community Koreans.
Gingival crevicular fluid MMP-8 and -13 and TIMP-1 levels in patients with rheumatoid arthritis and inflammatory periodontal disease.
Gingival Tissue and Crevicular Fluid Co-operation in Adult Periodontitis.
Gingival Tissue Inflammation Promotes Increased Matrix Metalloproteinase-12 Production by CD200R
Granulocyte elastase, matrix metalloproteinase-8 and prostaglandin E2 in gingival crevicular fluid in matched clinical sites in smokers and non-smokers with persistent periodontitis.
Histological evaluation of peri-implant mucosal and gingival tissues in peri-implantitis, peri-implant mucositis and periodontitis patients: a cross-sectional clinical study.
Host-Modulation Therapy and Chair-Side Diagnostics in the Treatment of Peri-Implantitis.
Human leukocyte antigens are associated with salivary level of active MMP-8.
Identification of a cytokine-induced repressor of interleukin-1 stimulated expression of stromelysin 1 (MMP-3).
Identification of pathogen and host-response markers correlated with periodontal disease.
Implant-safe test in patients with peri-implantitis.
Importance of MMP-8 in Salivary and Gingival Crevicular Fluids of Periodontitis Patients.
Increased expression of extracellular matrix metalloproteinase inducer is associated with matrix metalloproteinase-1 and -2 in gingival tissues from patients with periodontitis.
Increased local matrix metalloproteinase-8 expression in the periodontal connective tissues of smokers with periodontal disease.
Inhibition of matrix metalloproteinase-mediated periodontal bone loss in rats: a comparison of 6 chemically modified tetracyclines.
Interaction between the Wnt/?-catenin signaling pathway and the EMMPRIN/MMP-2, 9 route in periodontitis.
Is the progression rate of periodontitis related to subgingival biofilm composition or gingival crevicular fluid IL-1? and MMP-8 concentrations?
Lab-on-a-chip methods for point-of-care measurements of salivary biomarkers of periodontitis.
Langerhans cells express matrix metalloproteinases 9 and 2 and tissue inhibitors of metalloproteinases 1 and 2 in healthy human gingival tissue and in periodontitis.
Levels and molecular forms of MMP-7 (matrilysin-1) and MMP-8 (collagenase-2) in diseased human peri-implant sulcular fluid.
Levels of gingival crevicular metalloproteinases-8 and -9 in periodontitis.
Levels of myeloid-related proteins in saliva for screening and monitoring of periodontal disease.
Local administration of Tiludronic Acid downregulates important mediators involved in periodontal tissue destruction in experimental periodontitis in rats.
Local and systemic levels of aMMP-8 in gingivitis and stage 3 grade C periodontitis.
Local and systemic responses in matrix metalloproteinase 8-deficient mice during Porphyromonas gingivalis-induced periodontitis.
Longitudinal evaluation of clinical, spectral and tissue degradation biomarkers in progression of periodontitis among cigarette and electronic cigarette smokers.
Matrix metalloproteinase -7, -8, -9 and -13 in gingival tissue of patients with type 1 diabetes and periodontitis.
Matrix metalloproteinase gene polymorphisms and periodontitis susceptibility: a meta-analysis involving 6,162 individuals.
Matrix metalloproteinase-1 and -3 gene promoter polymorphisms in Japanese patients with periodontitis.
Matrix metalloproteinase-1 and -8 in gingival crevicular fluid during orthodontic tooth movement: a pilot study during 1 month of follow-up after fixed appliance activation.
Matrix metalloproteinase-8 levels in oral samples as a biomarker for periodontitis in the Chinese population: an observational study.
Matrix metalloproteinases (MMPs) in oral diseases.
Matrix metalloproteinases and inflammatory cytokines in oral fluid of patients with chronic generalized periodontitis and various construction materials.
Matrix metalloproteinases and inflammatory cytokines in the oral fluid of patients with chronic generalized periodontitis various structural materials restoration of teeth and dentition.
Matrix metalloproteinases and inhibitors in dentistry.
Matrix metalloproteinases and myeloperoxidase in gingival crevicular fluid provide site-specific diagnostic value for chronic periodontitis.
Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients.
Matrix metalloproteinases and their inhibitors in gingival mast cells in persons with and without human immunodeficiency virus infection.
Matrix Metalloproteinases, Tissue Inhibitor of Matrix Metalloproteinase-1, and Laminin-5 ?2 Chain Immunolocalization in Gingival Tissue of Endotoxin-Induced Periodontitis in Rats: Effects of Low-Dose Doxycycline and Alendronate.
Matrix metalloproteinases, tissue inhibitor of matrix metalloproteinase-1, and laminin-5 gamma2 chain immunolocalization in gingival tissue of endotoxin-induced periodontitis in rats: effects of low-dose doxycycline and alendronate.
Meta-analysis of the association between serum and gingival crevicular fluid matrix metalloproteinase-9 and periodontitis.
Microarray and quantitative RT-PCR analyses in calcium-channel blockers induced gingival overgrowth tissues of periodontitis patients.
MMP-2, MMP-9 and TIMP-2 gene polymorphisms in Chinese patients with generalized aggressive periodontitis.
MMP-8 -799 C>T genetic polymorphism is associated with the susceptibility to chronic and aggressive periodontitis in Taiwanese.
MMP-8, TRAP-5, and OPG Levels in GCF Diagnostic Potential to Discriminate between Healthy Patients', Mild and Severe Periodontitis Sites.
MMP-8-Responsive Polyethylene Glycol Hydrogel for Intraoral Drug Delivery.
Modulation of matrix metalloproteinase activities in periodontitis as a treatment strategy.
Modulation of Matrix Metalloproteinase and Cytokine Production by Licorice Isolates Licoricidin and Licorisoflavan A: Potential Therapeutic Approach for Periodontitis.
Molecular forms and fragments of salivary MMP-8 in relation to periodontitis.
Morphometric and histopathological evaluation of the effect of grape seed proanthocyanidin on alveolar bone loss in experimental diabetes and periodontitis.
Myricetin suppresses LPS-induced MMP expression in human gingival fibroblasts and inhibits osteoclastogenesis by downregulating NFATc1 in RANKL-induced RAW 264.7 cells.
Neutrophil elastase activity, levels of prostaglandin E2, and matrix metalloproteinase-8 in refractory periodontitis sites in smokers and non-smokers.
Non-Surgical Periodontal Therapy Reduces Saliva Adipokines and Matrix Metalloproteinases Levels in Periodontitis.
Origin of MMP-8 and Lactoferrin levels from gingival crevicular fluid, salivary glands and whole saliva.
Patterns of Salivary Analytes Provide Diagnostic Capacity for Distinguishing Chronic Adult Periodontitis from Health.
Peri-Implant Sulcus Fluid (PISF) Matrix Metalloproteinase (MMP) -8 Levels in Peri-Implantitis.
Periodontitis and Endothelial Dysfunction: Periodontal Clinical Parameters and Levels of Salivary Markers Interleukin-1?, Tumor Necrosis Factor-?, Matrix Metalloproteinase-2, Tissue Inhibitor of Metalloproteinases-2 Complex, and Nitric Oxide.
Periodontitis and peri-implantitis tissue levels of Treponema denticola-CTLP and its MMP-8 activating ability.
Pilot Study on Oral Health Status as Assessed by an Active Matrix Metalloproteinase-8 Chairside Mouthrinse Test in Adolescents.
Pilot Study on the Genetic Background of an Active Matrix Metalloproteinase-8 Test in Finnish Adolescents.
Porphyromonas gingivalis-mediated shedding of extracellular matrix metalloproteinase inducer (EMMPRIN) by oral epithelial cells: a potential role in inflammatory periodontal disease.
Possible relationship between periodontitis and dementia in a North Indian old age population: a pilot study.
Predictive Periodontitis: The Most Promising Salivary Biomarkers for Early Diagnosis of Periodontitis.
Proteinase-activated receptor-2 (PAR2) agonist causes periodontitis in rats.
Reduced expression of lipopolysaccharide-induced CXC chemokine in Porphyromonas gingivalis-induced experimental periodontitis in matrix metalloproteinase-8 null mice.
Release and activation of matrix metalloproteinase 8 from human neutrophils triggered by the leukotoxin of Actinobacillus actinomycetemcomitans.
Runt-related gene 2 is involved in the inhibition of matrix metalloproteinase-13 expression by roxithromycin in human gingival epithelial cell cultures.
Saliva and serum biomarkers in periodontitis and coronary artery disease.
Salivary biomarker combination prediction model for the diagnosis of periodontitis in a Taiwanese population.
Salivary biomarkers for discriminating periodontitis in the presence of diabetes.
Salivary biomarkers of existing periodontal disease: a cross-sectional study.
Salivary Colony Stimulating Factor-1 and Interleukin-34 in Periodontal Disease.
Salivary Diagnostics-Point-of-Care diagnostics of MMP-8 in dentistry and medicine.
Salivary interleukin-6, matrix metalloproteinase-8, and osteoprotegerin in patients with periodontitis and diabetes.
Salivary matrix metalloproteinase (MMP)-8 as a biomarker for periodontitis: A PRISMA-compliant systematic review and meta-analysis.
Salivary matrix metalloproteinase (MMP-8) levels and gelatinase (MMP-9) activities in patients with type 2 diabetes mellitus.
Salivary Matrix Metalloproteinase-8 and -9 and Myeloperoxidase in Relation to Coronary Heart and Periodontal Diseases: A Subgroup Report from the PAROKRANK Study (Periodontitis and Its Relation to Coronary Artery Disease).
Salivary matrix metalloproteinase-8 in patients with and without coronary heart disease may indicate an increased susceptibility to periodontal disease.
Salivary MMP-13 gender differences in periodontitis: A cross-sectional study from Sweden.
Salivary MMP-8, TIMP-1, and ICTP as markers of advanced periodontitis.
Scientific basis of a matrix metalloproteinase-8 specific chair-side test for monitoring periodontal and peri-implant health and disease.
Simvastatin, an HMG-CoA reductase inhibitor, reduced the expression of matrix metalloproteinase-9 (Gelatinase B) in osteoblastic cells and HT1080 fibrosarcoma cells.
Smoking affects diagnostic salivary periodontal disease biomarker levels in adolescents.
Smoking confounds the periodontal diagnostics using saliva biomarkers.
Smoking modulates interleukin-6:interleukin-10 and RANKL:osteoprotegerin ratios in the periodontal tissues.
Statin intake is associated with MMP-1 level in gingival crevicular fluid of patients with periodontitis.
Targeted salivary biomarkers for discrimination of periodontal health and disease(s).
Temporal expression of metalloproteinase-8 and -13 and their relationships with extracellular matrix metalloproteinase inducer in the development of ligature-induced periodontitis in rats.
The analysis of matrix metalloproteinase-8 in gingival crevicular fluid and periodontal diseases.
The Association of Matrix Metalloproteinase Gene Polymorphisms and Periodontitis: An Overview.
The effect of smoking on the mRNA expression of MMPs and TIMP-1 in untreated chronic periodontitis patients: a cross-sectional study.
The effect of subgingival controlled-release delivery of chlorhexidine chip on clinical parameters and matrix metalloproteinase-8 levels in gingival crevicular fluid.
The effects of periodontal therapy on gingival crevicular fluid matrix metalloproteinase-8, interleukin-6 and prostaglandin E2 levels in patients with rheumatoid arthritis.
The Effects of Selective COX-2 Inhibitor/Celecoxib and Omega-3 Fatty Acid on Matrix Metalloproteinases, TIMP-1, and Laminin-5gamma2-Chain Immunolocalization in Experimental Periodontitis.
The modulation of the TREM-1/PGLYRP1/MMP-8 axis in peri-implant diseases.
The potential of salivary biomarkers for predicting the sensitivity and monitoring the response to nonsurgical periodontal therapy: A preliminary assessment.
The role of extracellular matrix metalloproteinase inducer glycosylation in regulating matrix metalloproteinases in periodontitis.
The Short-Term Effectiveness of Non-Surgical Treatment in Reducing Levels of Interleukin-1? and Proteases in Gingival Crevicular Fluid From Patients With Type 2 Diabetes Mellitus and Chronic Periodontitis.
The short-term effectiveness of non-surgical treatment in reducing levels of interleukin-1beta and proteases in gingival crevicular fluid from patients with type 2 diabetes mellitus and chronic periodontitis.
The temporal expression and localization of extracellular matrix metalloproteinase inducer (EMMPRIN) during the development of perio-dontitis in an animal model.
Tissue inhibitor of metalloproteinases-1, matrix metalloproteinases-1 and -8, and collagenase activity levels in peri-implant crevicular fluid after implantation.
Toll-like receptor (TLR) and matrix metalloproteinase (MMP) polymorphisms and periodontitis susceptibility: a meta-analysis.
Use of a fluorogenic septapeptide matrix metalloproteinase assay to assess responses to periodontal treatment.
Use of host- and bacteria-derived salivary markers in detection of periodontitis: a cumulative approach.
Validation of Periodontitis Screening Model Using Socio-Demographic, Systemic and Molecular Information in a Korean Population.
[Detection and significance of IL-1beta and MMP-8 in patients with periodontitis of whole unstimulated saliva]
Peripheral Arterial Disease
Matrix metalloproteinase-2 dysregulation in type 1 diabetes.
Peripheral Nerve Injuries
Acute- and late-phase matrix metalloproteinase (MMP)-9 activity is comparable in female and male rats after peripheral nerve injury.
Endoneurial remodeling by TNFalph- and TNFalpha-releasing proteases. A spatial and temporal co-localization study in painful neuropathy.
Peritoneal Fibrosis
Inhibitory effects of matrix metalloproteinase inhibitor ONO-4817 on morphological alterations in chlorhexidine gluconate-induced peritoneal sclerosis rats.
Peritoneal Neoplasms
Matrix metalloproteinase inhibition prevents colon cancer peritoneal carcinomatosis development and prolongs survival in rats.
Peritonitis
Collagenase 2/matrix metalloproteinase 8 in critically ill patients with secondary peritonitis.
Colonic anastomotic strength and matrix metalloproteinase activity in an experimental model of bacterial peritonitis.
Early diagnosis of CAPD peritonitis using a new test kit for detection of matrix metalloproteinase (MMP)-9.
In vivo processing of CXCL5 (LIX) by matrix metalloproteinase (MMP)-2 and MMP-9 promotes early neutrophil recruitment in IL-1?-induced peritonitis.
Intestine-Derived Matrix Metalloproteinase-8 Is a Critical Mediator of Polymicrobial Peritonitis.
Measurement of innate immune response biomarkers in peritoneal dialysis effluent using a rapid diagnostic point-of-care device as a diagnostic indicator of peritonitis.
Pheochromocytoma
A novel nerve growth factor-responsive element in the stromelysin-1 (transin) gene that is necessary and sufficient for gene expression in PC12 cells.
KI-67 AND hTERT expression can aid in the distinction between malignant and benign pheochromocytoma and paraganglioma.
The metalloproteinase stromelysin-1 (transin) mediates PC12 cell growth cone invasiveness through basal laminae.
Pituitary Neoplasms
Inhibition of estrogen-induced pituitary tumor growth and angiogenesis in Fischer 344 rats by the matrix metalloproteinase inhibitor batimastat.
Regulating effect of MMP-9 and TIMP-1 in pituitary adenoma invasion.
Regulation of pituitary hormones and cell proliferation by components of the extracellular matrix.
The relationship between MRI invasive features and expression of EMMPRIN, galectin-3, and microvessel density in pituitary adenoma.
Placenta Accreta
Differential expression of growth-, angiogenesis- and invasion-related factors in the development of placenta accreta.
Placenta Previa
The frequency and clinical significance of intra-uterine infection and inflammation in patients with placenta previa and preterm labor and intact membranes.
Plasmacytoma
Expression and induction of collagenases (MMP-8 and -13) in plasma cells associated with bone-destructive lesions.
Pleural Effusion
Expression of matrix metalloproteinase-9 in pleural effusions of tuberculosis and lung cancer.
Matrix metalloproteinase levels in the differentiation of parapneumonic pleural effusions.
Occurrence of matrix metalloproteinases and tissue inhibitors of metalloproteinases in tuberculous pleuritis.
Pleural fluid analysis of lung cancer vs benign inflammatory disease patients.
[Matrix metalloproteinases and their inhibitors in lung cancer with malignant pleural effusion]
Pleural Effusion, Malignant
Phase I study of intrapleural batimastat (BB-94), a matrix metalloproteinase inhibitor, in the treatment of malignant pleural effusions.
Pleurisy
Occurrence of matrix metalloproteinases and tissue inhibitors of metalloproteinases in tuberculous pleuritis.
Pneumoconiosis
[Serum levels of matrix metalloproteinase 9 and 19 in the patients with pneumoconiosis].
Pneumonia
A critical role for ABC transporters in persistent lung inflammation in the development of emphysema after smoke exposure.
Activated protein C protection from lung inflammation in endotoxin-induced injury.
Complex regulation of pulmonary inflammation and fibrosis by CCL18.
Hospital acquired pneumonia with high-risk bacteria is associated with increased pulmonary matrix metalloproteinase activity.
Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation.
Matrix metalloproteinase-8 inactivates macrophage inflammatory protein-1 alpha to reduce acute lung inflammation and injury in mice.
Matrix metalloproteinase-8: a useful biomarker to refine the diagnosis of community-acquired pneumonia upon intensive care unit admission?
Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase.
Metalloelastase (MMP-12) induced inflammatory response in mice airways: effects of dexamethasone, rolipram and marimastat.
MMP-8 deficiency increases TLR/RAGE ligands S100A8 and S100A9 and exacerbates lung inflammation during endotoxemia.
Nitrative stress in inflammatory lung diseases.
Pretreatment of a matrix metalloproteases inhibitor and aprotinin attenuated the development of acute pancreatitis-induced lung injury in rat model.
Pulmonary delivery of the broad-spectrum matrix metalloproteinase inhibitor marimastat diminishes multiwalled carbon nanotube-induced circulating bioactivity without reducing pulmonary inflammation.
Pulmonary matrix metalloproteinase excess in hospital-acquired pneumonia.
Sequential targeted deficiency of SP-A and -D leads to progressive alveolar lipoproteinosis and emphysema.
Pneumoperitoneum
Effect of CO2 pneumoperitoneum on the proliferation of human ovarian cancer cell line SKOV-3 and the expression of NM23-H1 and MMP-2.
Pneumoperitoneum augmented tumor invasiveness is abolished by matrix metalloproteinase blockade.
Polycystic Kidney Diseases
A possible role for metalloproteinases in renal cyst development.
Matrix metalloproteinase activity in human intrahepatic biliary epithelial cell lines from patients with autosomal dominant polycystic kidney disease.
Polycystic Kidney, Autosomal Dominant
Identification of MMP1 as a novel risk factor for intracranial aneurysms in ADPKD using iPSC models.
Matrix metalloproteinase activity in human intrahepatic biliary epithelial cell lines from patients with autosomal dominant polycystic kidney disease.
Polycystic Ovary Syndrome
Elevated matrix metalloproteinase-8 in saliva and serum in polycystic ovary syndrome and association with gingival inflammation.
Increased Prolidase Activity and Oxidative Stress in PCOS.
Matrix metalloproteinases 2 and 9 and their tissue inhibitors in the follicular fluid of patients with polycystic ovaries undergoing in vitro fertilisation.
Polyneuropathies
Collagen synthesis and degradation in polyneuropathy and myopathies.
Matrix metalloproteinase upregulation in chronic inflammatory demyelinating polyneuropathy and nonsystemic vasculitic neuropathy.
Porcine Reproductive and Respiratory Syndrome
Clarithromycin and dexamethasone show similar anti-inflammatory effects on distinct phenotypic chronic rhinosinusitis: an explant model study.
Pouchitis
Expression of cytokines, inducible nitric oxide synthase, and matrix metalloproteinases in pouchitis: effects of probiotic treatment.
Pre-Eclampsia
Association between matrix metalloproteinase (MMP)-2 polymorphisms and MMP-2 levels in hypertensive disorders of pregnancy.
Comparative assessment of matrix metalloproteinase (MMP)-2 and MMP-9, and their inhibitors, tissue inhibitors of metalloproteinase (TIMP)-1 and TIMP-2 in preeclampsia and gestational hypertension.
Effects of Matrix Metalloproteinase (MMP)-2 Polymorphisms on Responsiveness to Antihypertensive Therapy of Women with Hypertensive Disorders of Pregnancy.
Elevated hyaluronan and extracellular matrix metalloproteinase inducer levels in women with preeclampsia.
Gelatinase matrix metalloproteinase (MMP)-2 and MMP-9 of the umbilical cord blood in preeclampsia.
In vitro migration of cytotrophoblasts through a decidual endothelial cell monolayer: the role of matrix metalloproteinases.
Interaction of cocultured decidual endothelial cells and cytotrophoblasts in preeclampsia.
Interleukin-4 -590 (C>T), toll-like receptor-2 +2258 (G>A) and matrix metalloproteinase-9 -1562 (C>T) polymorphisms in pre-eclampsia.
Loss of Thrombomodulin in Placental Dysfunction in Preeclampsia.
Matrix metalloproteinase (MMP)-9 genotypes and haplotypes in preeclampsia and gestational hypertension.
Matrix metalloproteinase multiplex screening identifies increased MMP-2 urine concentrations in women predicted to develop preeclampsia.
Matrix metalloproteinase-2 C-735T and its interaction with matrix metalloproteinase-7 A-181G polymorphism are associated with the risk of preeclampsia: influence on total antioxidant capacity and blood pressure.
MMP-2 levels are elevated in the plasma of women who subsequently develop preeclampsia.
MMP-8 C-799T and MMP-8 C+17G polymorphisms in mild and severe preeclampsia: Association between MMP-8 C-799T with susceptibility to severe preeclampsia.
Modulation of matrix metalloproteinase secretion by adenosine A3 receptor in preeclamptic villous explants.
Preeclampsia associates with RECK-dependent decrease in human trophoblasts migration and invasion.
RNA interference-mediated silencing of laminin receptor 1 (LR1) suppresses migration and invasion and down-regulates matrix metalloproteinase (MMP)-2 and MMP-9 in trophoblast cells: implication in the pathogenesis of preeclampsia.
The effect of serum from women with preeclampsia on JAR (trophoblast-like) cell line.
[Clinical significance of KiSS-1 and matrix metalloproteinase-9 expression in trophoblasts of women with preeclampsia and their relation to perinatal outcome of neonates]
[Differences between the expression of matrix metalloproteinase-2, 9 in preeclampsia and normal placental tissues]
[Differential expression of extracellular matrix metalloproteinase inducer in normal placenta and preeclampsia placenta]
[Expression of trophoblast invasion related genes mRNA and protein in human placenta in preeclampsia]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Expression of matrix metalloproteinase (MMP) and tissue inhibitor of MMP (TIMP) genes in blasts of infant acute lymphoblastic leukemia with organ involvement.
The Contribution of MMP-8 Promoter Genotypes to Childhood Leukemia.
Prediabetic State
Matrix metalloproteinase-8 analysis in patients with periodontal disease with prediabetes or type 2 diabetes mellitus: A systematic review.
Whole Salivary Interleukin-6 and Matrix Metalloproteinase-8 Levels in Chronic Periodontitis Patients With and Without Prediabetes.
Pregnancy Complications
Mapping themes trends and knowledge structure of trophoblastic invasion, a bibliometric analysis from 2012-2021.
Matrix metalloproteinase and tissue inhibitors of metalloproteinases gene polymorphisms in disorders that influence fertility and pregnancy complications: A systematic review and meta-analysis.
Prehypertension
Effects of androgen on vascular and inflammatory biomarkers in a female hypertensive population.
Premature Birth
About one-half of early spontaneous preterm deliveries can be identified by a rapid matrix metalloproteinase-8 (MMP-8) bedside test at the time of mid-trimester genetic amniocentesis.
Changes in matrix metalloproteinase (MMP)-2 and MMP-9 in the fetal amnion and chorion during gestation and at term and preterm labor.
Class I to III Histone Deacetylases Differentially Regulate Inflammation-Induced Matrix Metalloproteinase 9 Expression in Primary Amnion Cells.
Detection of ureaplasmas by the polymerase chain reaction in the amniotic fluid of patients with cervical insufficiency.
Effect of clindamycin treatment on vaginal inflammatory markers in pregnant women with bacterial vaginosis and a positive fetal fibronectin test.
Midtrimester amniotic fluid matrix metalloproteinase-8 (MMP-8) levels above the 90th percentile are a marker for subsequent preterm premature rupture of membranes.
Role of MMP-1, MMP-8 and MMP-9 gene polymorphisms in preterm birth.
The Relationship Between Matrix Metalloproteinase-8 in After Birth Oral Fluid and Acute Histologic Chorioamnionitis in Preterm Delivery.
Presbyopia
Enhancing trabecular outflow by disrupting the actin cytoskeleton, increasing uveoscleral outflow with prostaglandins, and understanding the pathophysiology of presbyopia interrogating Mother Nature: asking why, asking how, recognizing the signs, following the trail.
Pressure Ulcer
Involvement of proteolytic enzymes--plasminogen activators and matrix metalloproteinases--in the pathophysiology of pressure ulcers.
Wound fluids from human pressure ulcers contain elevated matrix metalloproteinase levels and activity compared to surgical wound fluids.
Primary Myelofibrosis
Plasma matrix metalloproteinase and tissue inhibitor of metalloproteinase in patients with agnogenic myeloid metaplasia or idiopathic primary myelofibrosis.
Prion Diseases
Tau Protein Phosphorylated at Threonine-231 is Expressed Abundantly in the Cerebellum in Prion Encephalopathies.
Proctitis
Clinical significance of increased gelatinolytic activity in the rectal mucosa during external beam radiation therapy of prostate cancer.
Prolactinoma
Matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-2: Prognostic biological markers in invasive prolactinomas.
Prostatic Hyperplasia
Gamma-aminobutyric acid as a promoting factor of cancer metastasis; induction of matrix metalloproteinase production is potentially its underlying mechanism.
Matrix metalloproteinase 9 expression in primary human prostatic adenocarcinoma and benign prostatic hyperplasia.
Plasminogen activator activities in short-term tissue cultures of benign prostatic hyperplasia and prostatic carcinoma.
Prostatic Neoplasms
A prostate secretory protein94-derived synthetic peptide PCK3145 inhibits VEGF signalling in endothelial cells: Implication in tumor angiogenesis.
A Randomized Phase II Trial of the Matrix Metalloproteinase Inhibitor BMS-275291 in Hormone-Refractory Prostate Cancer Patients with Bone Metastases.
Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasion.
Anti-invasive activity of diallyl disulfide through tightening of tight junctions and inhibition of matrix metalloproteinase activities in LNCaP prostate cancer cells.
Anti-vascular endothelial growth factor receptor 2 antibody reduces tumorigenicity and metastasis in orthotopic prostate cancer xenografts via induction of endothelial cell apoptosis and reduction of endothelial cell matrix metalloproteinase type 9 production.
Blueberry flavonoids inhibit matrix metalloproteinase activity in DU145 human prostate cancer cells.
Butein suppresses the expression of nuclear factor-kappa B-mediated matrix metalloproteinase-9 and vascular endothelial growth factor in prostate cancer cells.
Cleavage of the Perlecan-Semaphorin 3A-Plexin A1-Neuropilin-1 (PSPN) Complex by Matrix Metalloproteinase 7/Matrilysin Triggers Prostate Cancer Cell Dyscohesion and Migration.
Clinical significance of increased gelatinolytic activity in the rectal mucosa during external beam radiation therapy of prostate cancer.
Differential regulation of matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2 expression in co-cultures of prostate cancer and stromal cells.
EMMPRIN regulates cytoskeleton reorganization and cell adhesion in prostate cancer.
Expression and functional role of CCR9 in prostate cancer cell migration and invasion.
Genistein inhibits matrix metalloproteinase type 2 activation and prostate cancer cell invasion by blocking the transforming growth factor beta-mediated activation of mitogen-activated protein kinase-activated protein kinase 2-27-kDa heat shock protein pathway.
Growth factor regulation of secreted matrix metalloproteinase and plasminogen activators in prostate cancer cells, normal prostate fibroblasts and normal osteoblasts.
Heterogeneous activation of MMP-9 due to prostate cancer-bone interaction.
High matrix metalloproteinase-to-E-cadherin ratio measured by bicolor fluorescent in situ hybridization is associated with lymphangiogenesis and lymph node metastasis in prostate cancer.
Id-1 and Id-2 proteins as molecular markers for human prostate cancer progression.
Immunocytochemical detection of matrix metalloproteinase expression in prostate cancer.
Influence of genistein isoflavone on matrix metalloproteinase-2 expression in prostate cancer cells.
Inhibition of angiogenesis and invasion by 3,3'-diindolylmethane is mediated by the nuclear factor-kappaB downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancer.
Inhibition of matrix metalloproteinase activity in DU145 human prostate cancer cells by flavonoids from lowbush blueberry (Vaccinium angustifolium): possible roles for protein kinase C and mitogen-activated protein-kinase-mediated events.
MAPKAPK2 and HSP27 are downstream effectors of p38 MAP kinase-mediated matrix metalloproteinase type 2 activation and cell invasion in human prostate cancer.
Matrilysin expression in the involuting rat ventral prostate.
Matrix metalloproteinase 9 and prostate-cancer risk : a meta-analysis of 1,059 participants.
Matrix metalloproteinase activity and osteoclasts in experimental prostate cancer bone metastasis tissue.
Matrix metalloproteinase activity, bone matrix turnover, and tumor cell proliferation in prostate cancer bone metastasis.
Matrix metalloproteinase and heparin-stimulated serine proteinase activities in post-prostate massage urine of men with prostate cancer.
Matrix metalloproteinase inhibitor Ro 28-2653 in combination with estramustine: tumor-reducing effects on hormone-sensitive prostate cancer in rats.
Membranous type matrix metalloproteinase 16 induces human prostate cancer metastasis.
miR-21 may acts as an oncomir by targeting RECK, a matrix metalloproteinase regulator, in prostate cancer.
Modulation of prostate cancer growth in bone microenvironments.
National Cancer Institute intramural approach to advanced prostate cancer.
Over-expression of extracellular matrix metalloproteinase inducer in prostate cancer is associated with high risk of prostate-specific antigen relapse after radical prostatectomy.
Penta-O-galloyl-beta-D-glucose suppresses prostate cancer bone metastasis by transcriptionally repressing EGF-induced MMP-9 expression.
Pharmacological inhibition of FGF receptor signaling inhibits LNCaP prostate tumor growth, promatrilysin, and PSA expression.
Phenotypic Characterization of Prostate Cancer LNCaP Cells Cultured within a Bioengineered Microenvironment.
Plasminogen activator and matrix metalloproteinase production and extracellular matrix degradation by rat prostate cancer cells in vitro: correlation with metastatic behavior in vivo.
Proanthocyanidins from the American Cranberry (Vaccinium macrocarpon) inhibit matrix metalloproteinase-2 and matrix metalloproteinase-9 activity in human prostate cancer cells via alterations in multiple cellular signalling pathways.
Prostate cancer metastasis and soy isoflavones: a dogfight over a bone.
Reduced CD147 expression is linked to ERG fusion-positive prostate cancers but lacks substantial impact on PSA recurrence in patients treated by radical prostatectomy.
Rho kinase and matrix metalloproteinase inhibitors cooperate to inhibit angiogenesis and growth of human prostate cancer xenotransplants.
RNA interference mediated suppression of TRPV6 inhibits the progression of prostate cancer in vitro by modulating cathepsin B and MMP9 expression.
RNase L Suppresses Androgen Receptor Signaling, Cell Migration and Matrix Metalloproteinase Activity in Prostate Cancer Cells.
Roles of matrix metalloproteinases and their natural inhibitors in prostate cancer progression.
Serum biomarkers reflecting specific tumor tissue remodeling processes are valuable diagnostic tools for lung cancer.
Significance of MMP-2 expression in prostate cancer: an immunohistochemical study.
Suppression of prostate cancer invasive potential and matrix metalloproteinase activity by E-cadherin transfection.
The new synthetic matrix metalloproteinase inhibitor (Roche 28-2653) reduces tumor growth and prolongs survival in a prostate cancer standard rat model.
The ratio of matrix metalloproteinase to E-cadherin expression: a pilot study to assess mRNA and protein expression among African American prostate cancer patients.
The relative mRNA expression levels of matrix metalloproteinase to E-cadherin in prostate biopsy specimens distinguishes organ-confined from advanced prostate cancer at radical prostatectomy.
The role of extracellular matrix metalloproteinase inducer protein in prostate cancer progression.
The role of the androgen receptor in prostate cancer-induced platelet aggregation and platelet-induced invasion.
Thymoquinone inhibits IL-7-induced tumor progression and metastatic invasion in prostate cancer cells by attenuating matrix metalloproteinase activity and Akt/NF-?B signaling.
Unripe Rubus coreanus Miquel suppresses migration and invasion of human prostate cancer cells by reducing matrix metalloproteinase expression.
Proteinuria
Comparison of renal and vascular protective effects between telmisartan and amlodipine in hypertensive patients with chronic kidney disease with mild renal insufficiency.
Ureic clearance granule, alleviates renal dysfunction and tubulointerstitial fibrosis by promoting extracellular matrix degradation in renal failure rats, compared with enalapril.
Pruritus
Evaluation of Association Between the Serum Levels of MMP-9 and MMP-9/TIMPs With Soluble Forms of Selectins and Itching Induced by Sulfur Mustard.
Matrix Metalloproteinase-8 Is Involved in Dermal Nerve Growth: Implications for Possible Application to Pruritus from In Vitro Models.
Pseudomonas Infections
Extracellular matrix metalloproteinase inducer enhances host resistance against pseudomonas aeruginosa infection through MAPK signaling pathway.
Psoriasis
Interleukin-17A enhances the production of CD147/extracellular matrix metalloproteinase inducer by monocytes from patients with psoriasis.
Plasma TGF-beta(1), TIMP-1, MMP-1 and IL-18 as a combined biomarker of psoriasis activity.
Plasma TGF-beta1, TIMP-1, MMP-1 and IL-18 as a combined biomarker of psoriasis activity.
Psoriasis and Diabetes, a Dangerous Association: Evaluation of Insulin Resistance, Lipid Abnormalities, and Cardiovascular Risk Biomarkers.
Serum of Patients with Psoriasis Modulates the Production of MMP-9 and TIMP-1 in Cells of Monocytic Lineage.
Targeting miR-21 to treat psoriasis.
[Expression of genes for metalloproteinases (MMP-1, MMP-2, MMP-9, and MMP-12) associated with psoriasis].
Pterygium
Continuous exposure of nicotine and cotinine retards human primary pterygium cell proliferation and migration.
Cyclosporine A Downregulates MMP-3 and MMP-13 Expression in Cultured Pterygium Fibroblasts.
Detection and comparison of matrix metalloproteinase in primary and recurrent pterygium fibroblasts.
Inhibition of Pterygium Fibroblast Migration and Outgrowth by Bevacizumab and Cyclosporine A Involves Down-Regulation of Matrix Metalloproteinases-3 and -13.
Matrix metalloproteinase-9 expression in pterygium.
The Association of MMP-8 Genotypes with Pterygium.
Pulmonary Disease, Chronic Obstructive
Activity of matrix metalloproteinase in airway epithelial cells of COPD patients.
Association between the interleukin-13 gene and development of chronic obstructive pulmonary disease in southern Chinese Han population: a case-control study.
Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population.
Cigarette smoke-induced epithelial expression of WNT-5B: implications for COPD.
Determination of enzyme matrix metalloproteinases-9 and immune status as indicators of development of the environmental diseases.
Effect of Liuweibuqi capsules on the balance between MMP-9 and TIMP1 and viability of alveolar macrophages in COPD.
Effects of resveratrol and genistein on nuclear factor??B, tumor necrosis factor?? and matrix metalloproteinase?9 in patients with chronic obstructive pulmonary disease.
EMMPRIN (CD147) REGULATION OF MMP-9 IN BRONCHIAL EPITHELIAL CELLS IN COPD.
Evaluation of collagenase activity, matrix metalloproteinase-8, and matrix metalloproteinase-13 in horses with chronic obstructive pulmonary disease.
Expression and localization of the MMP inhibitor RECK in a rat model of COPD: its involvement in the development of COPD.
Expression of Matrix Metalloproteinase-2, Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1, and Changes in Alveolar Septa in Patients with Chronic Obstructive Pulmonary Disease.
Gene expression profiling in lung tissues from mice exposed to cigarette smoke, lipopolysaccharide, or smoke plus lipopolysaccharide by inhalation.
Gene-environment interaction between the MMP9 C-1562T promoter variant and cigarette smoke in the pathogenesis of chronic obstructive pulmonary disease.
Genetic Polymorphism of Matrix Metalloproteinase Family and Chronic Obstructive Pulmonary Disease Susceptibility: a Meta-analysis.
Genetic polymorphisms in chronic obstructive pulmonary disease.
Genetic polymorphisms of cytochrome p450 and matrix metalloproteinase in chronic obstructive pulmonary disease.
Genetic polymorphisms of matrix metalloproteinases: functional importance in the development of chronic obstructive pulmonary disease?
Glucocorticosteroids Differentially Regulate MMP-9 and Neutrophil Elastase in COPD.
Human Rhinovirus Infection Upregulates MMP-9 Production in Airway Epithelial Cells via NF-{kappa}B.
Impact of tobacco smoking on cytokine signaling via interleukin-17A in the peripheral airways.
Increase in the expression of matrix metalloproteinase-12 in the airways of rats with allergic bronchial asthma.
Increased activity of matrix metalloproteinase-8 and matrix metalloproteinase-9 in induced sputum from patients with COPD.
Increased matrix metalloproteinase-9 to tissue inhibitor of metalloproteinase-1 ratio in smokers with airway hyperresponsiveness and accelerated lung function decline.
Macrophages and the pathogenesis of COPD.
Matrix metalloproteinase gene polymorphisms: lack of association with chronic obstructive pulmonary disease in a Brazilian population.
Matrix metalloproteinase-12 is a therapeutic target for asthma in children and young adults.
Matrix metalloproteinase-9 -1562C/T promoter polymorphism confers risk for COPD: a meta-analysis.
Matrix metalloproteinase-9 in lung remodeling.
Matrix metalloproteinases -8 and -9 in the Airways, Blood and Urine During Exacerbations of COPD.
Matrix metalloproteinases -8, -9 and -12 in smokers and patients with stage 0 COPD.
Metalloelastase (MMP-12) induced inflammatory response in mice airways: effects of dexamethasone, rolipram and marimastat.
MMP-2 (-1306 C/T) Polymorphism Affects Serum Matrix Metalloproteinase (MMP)-2 Levels and Correlates with Chronic Obstructive Pulmonary Disease Severity: A Case-Control Study of MMP-1 and -2 in a Tunisian Population.
MMP-3 (-1171 5A/6A; Lys45Glu) variants affect serum levels of matrix metalloproteinase (MMP)-3 and correlate with severity of COPD: A study of MMP-3, MMP-7 and MMP-12 in a Tunisian population.
MMP-8, MMP-9 and Neutrophil Elastase in Peripheral Blood and Exhaled Breath Condensate in COPD.
MMP-9 genetic polymorphism may confer susceptibility to COPD.
Nitrative stress in inflammatory lung diseases.
Non-small cell lung cancer is characterised by a distinct inflammatory signature in serum compared with chronic obstructive pulmonary disease.
Pathogenesis of cigarette smoke-induced chronic obstructive pulmonary disease and therapeutic effects of glucocorticoids and N-acetylcysteine in rats.
Periodontal health and serum, saliva matrix metalloproteinases in patients with mild chronic obstructive pulmonary disease.
Polymorphisms in Matrix Metalloproteinase-1, -9 and -12 Genes and the Risk of Chronic Obstructive Pulmonary Disease in a Korean Population.
Proteomic Analysis in Lung Tissue of Smokers and COPD Patients.
Quantitative proteomic characterization of the lung extracellular matrix in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis.
Relationship between expression of matrix metalloproteinase-9 and adenylyl cyclase-associated protein 1 in chronic obstructive pulmonary disease.
Relationship between plasma matrix metalloproteinase levels, pulmonary function, bronchodilator response, and emphysema severity.
Rhinovirus-induces progression of lung disease in a mouse model of COPD via IL-33/ST2 signaling axis.
SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung.
Serological investigation of the collagen degradation profile of patients with chronic obstructive pulmonary disease or idiopathic pulmonary fibrosis.
Serum angiopoietin-like 4 is over-expressed in COPD patients: association with pulmonary function and inflammation.
Serum biomarkers reflecting specific tumor tissue remodeling processes are valuable diagnostic tools for lung cancer.
Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: Relationship to disease severity.
Sulphonamides: Deserving class as MMP inhibitors?
The effect of phosphatidylinositol-3 kinase inhibition on matrix metalloproteinase-9 and reactive oxygen species release from chronic obstructive pulmonary disease neutrophils.
The effect of selective phosphodiesterase isoenzyme inhibition on neutrophil function in vitro.
Tissue Inhibitor of Metalloproteinase-1 Promotes Polymorphonuclear Neutrophil (PMN) Pericellular Proteolysis by Anchoring Matrix Metalloproteinase-8 and -9 to PMN Surfaces.
TNF-alpha up-regulates matrix metalloproteinase-9 expression and activity in alveolar macrophages from patients with chronic obstructive pulmonary disease.
Transgenic expression of matrix metalloproteinase-9 causes adult-onset emphysema in mice associated with the loss of alveolar elastin.
Transient elevation of neutrophil proteinases in induced sputum during COPD exacerbation.
Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD.
[Influence of N-acetylcysteine on the cytokines and matrix metalloproteinases in chronic obstructive pulmonary disease rat models]
[Markers of airway remodeling in induced sputum from healthy smokers]
[Study on effect of anemoside B4 in improving COPD rats by regulating IL-12/STAT4 and IL-4/STAT6 signaling pathways].
[The expressions of TNF-alpha and MMP-9 in serum and MMP-1 mRNA in the bone tissue in chronic obstructive pulmonary disease patients of cold dryness syndrome in northwest China].
Pulmonary Edema
Caspase-1 Inhibitor Prevents Neurogenic Pulmonary Edema After Subarachnoid Hemorrhage in Mice.
Pulmonary Embolism
Antioxidant treatment protects against matrix metalloproteinase activation and cardiomyocyte injury during acute pulmonary thromboembolism.
Hemodynamic benefits of matrix metalloproteinase-9 inhibition by doxycycline during experimental acute pulmonary embolism.
L-arginine attenuates acute pulmonary embolism-induced increases in lung matrix metalloproteinase-2 and matrix metalloproteinase-9.
Matrix metalloproteinase inhibition attenuates right ventricular dysfunction and improves responses to dobutamine during acute pulmonary thromboembolism.
Metalloproteinase inhibition protects against cardiomyocyte injury during experimental acute pulmonary thromboembolism.
Pulmonary Emphysema
Liver growth factor treatment reverses emphysema previously established in a cigarette smoke exposure mouse model.
Loss of skin elasticity is associated with pulmonary emphysema, biomarkers of inflammation, and matrix metalloproteinase activity in smokers.
Neutrophil granule proteins in bronchoalveolar lavage fluid from subjects with subclinical emphysema.
Pulmonary emphysema and tumor microenvironment in primary lung cancer.
Surfactant protein D regulates NF-kappa B and matrix metalloproteinase production in alveolar macrophages via oxidant-sensitive pathways.
Pulmonary Fibrosis
An alternative therapy for idiopathic pulmonary fibrosis by doxycycline through matrix metalloproteinase inhibition.
Artesunate modulates expression of matrix metalloproteinases and their inhibitors as well as collagen-IV to attenuate pulmonary fibrosis in rats.
Discovery of Sulfated Small Molecule Inhibitors of Matrix Metalloproteinase-8.
Gene expressions and roles of matrix metalloproteinases-8 and tissue inhibitor of metalloproteinases-1 in hyperoxia-induced pulmonary fibrosis in neonatal rats.
Increased extracellular matrix metalloproteinase inducer (EMMPRIN) expression in pulmonary fibrosis.
Inhibition of bleomycin-induced pulmonary fibrosis in mice by the matrix metalloproteinase inhibitor batimastat.
Matrix metalloproteinases and tissue inhibitor of metalloproteinase-1 in sarcoidosis and IPF.
Upregulated miR-29c suppresses silica-induced lung fibrosis through the Wnt/?-catenin pathway in mice.
[Effect of atorvastatin on MMP-9 and TIMP-1 levels in bronchoalvcolar lavage fluid and serum of rats with bleomycin-induced pulmonary fibrosis].
[Feature changes of MMP-2/9 activities and TIMP-1/2 protein expressions during the progression of pulmonary fibrosis in rats]
Pulpitis
ASH1L Suppresses Matrix Metalloproteinase through Mitogen-activated Protein Kinase Signaling Pathway in Pulpitis.
Comparison of Neurokinin A, Substance P, Interleukin 8, and Matrix Metalloproteinase-8 Changes in Pulp tissue and Gingival Crevicular Fluid Samples of Healthy and Symptomatic Irreversible Pulpitis Teeth.
Erratum to Comparison of Neurokinin A, Substance P, Interleukin 8, and Matrix Metalloproteinase-8 Changes in Pulp tissue and Gingival Crevicular Fluid Samples of Healthy and Symptomatic Irreversible Pulpitis Teeth [J Endod 46 (2020) 1428-1437].
Levels of matrix metalloproteinase-8 and cold test in reversible and irreversible pulpitis.
Pyelonephritis
Association of mRNA Levels of IL6, MMP-8, GSS in Saliva and Pyelonephritis in Children.
Radicular Cyst
Comparative analysis of the immunohistochemical expression of collagen IV, MMP-9, and TIMP-2 in odontogenic cysts and tumors.
Expression of matrix metalloproteinase-8 and matrix metalloproteinase-13 in mast cells of human periapical lesions.
Modulation of Matrix Metalloproteinase 14, Tissue Inhibitor of Metalloproteinase 3, Tissue Inhibitor of Metalloproteinase 4, and Inducible Nitric Oxide Synthase in the Development of Periapical Lesions.
Rectal Neoplasms
Colorectal cancer or colon and rectal cancer? Clinicopathological comparison between colonic and rectal carcinomas.
Effect of Conjugated Linoleic Acid Supplementation on Inflammatory Factors and Matrix Metalloproteinase Enzymes in Rectal Cancer Patients Undergoing Chemoradiotherapy.
Effects of two conventional preoperative radiation schedules on anastomotic healing in the rat colon.
Refractive Errors
Association of matrix metalloproteinase gene polymorphisms with refractive error in Amish and Ashkenazi families.
Renal Insufficiency
Application of antibody array technology in the analysis of urinary cytokine profiles in patients with chronic kidney disease.
Biomechanical strain causes maladaptive gene regulation, contributing to Alport glomerular disease.
Renal Insufficiency, Chronic
Matrix metalloproteinase -2, -9 and arterial stiffness in children and adolescents: The role of chronic kidney disease, diabetes, and hypertension.
Nitric oxide stimulates the activity of a 72-kDa neutral matrix metalloproteinase in cultured rat mesangial cells.
Periodontal Inflammatory Burden and Salivary Matrix Metalloproteinase-8 Concentration Among Patients With Chronic Kidney Disease at the Predialysis Stage.
Progression of kidney disease in non-diabetic patients with coronary artery disease: predictive role of circulating matrix metalloproteinase-2, -3, and -9.
Reperfusion Injury
Apelin-13 attenuates injury following ischemic stroke by targeting matrix metalloproteinases (MMP), endothelin- B receptor, occludin/claudin-5 and oxidative stress.
Effects of Novel Semiselective Matrix Metalloproteinase Inhibitors on Ex Vivo Cardiac Structure-Function.
Evaluation of matrix metalloproteinase, myeloperoxidase, and oxidative damage in mesenteric ischemia-reperfusion injury.
Japan-China Joint Medical Workshop on Drug Discoveries and Therapeutics 2008: The need of Asian pharmaceutical researchers' cooperation.
Matrix metalloproteinase activation is an early event in doxorubicin-induced cardiotoxicity.
Matrix metalloproteinase inhibition decreases ischemia-reperfusion injury after lung transplantation.
Matrix metalloproteinase inhibition protects rat livers from prolonged cold ischemia-warm reperfusion injury.
Matrix metalloproteinase inhibitor (ONO-4817) attenuates ischemia-reperfusion injury in rat lung.
Matrix metalloproteinase-2 degrades the cytoskeletal protein alpha-actinin in peroxynitrite mediated myocardial injury.
Renal matrix metalloproteinase activity is unaffected by experimental ischemia-reperfusion injury and matrix metalloproteinase inhibition does not alter outcome of renal function.
Serum matrix metalloproteinase MMP-2 and MMP-9 in the late phase of ischemia and reperfusion injury in human orthotopic liver transplantation.
The role of matrix metalloproteinase inhibitors in ischemia-reperfusion injury in the liver.
[The impact of different duration of EA-pretreatment on expression of MMP-9 and VEGF in blood-brain barrier in rats with cerebral ischemia-reperfusion injury].
Reproductive Tract Infections
Influence of vaginal bacteria and D- and L-lactic acid isomers on vaginal extracellular matrix metalloproteinase inducer: implications for protection against upper genital tract infections.
Respiratory Distress Syndrome
Early Plasma Matrix Metalloproteinase Profiles Offer New Insight into the Biology and Prognosis of Pediatric Acute Respiratory Distress Syndrome.
Early Plasma Matrix Metalloproteinase Profiles: A Novel Pathway in Pediatric Acute Respiratory Distress Syndrome.
Matrix metalloproteinases and matrix metalloproteinase inhibitors in acute lung injury.
Matrix metalloproteinases-2, -8, and -9 and TIMP-2 in tracheal aspirates from preterm infants with respiratory distress.
Respiratory Insufficiency
Implications for matrix metalloproteinases as modulators of pediatric lung disease.
Serum MMP-8 and TIMP-1 in Critically Ill Patients with Acute Respiratory Failure: TIMP-1 Is Associated with Increased 90-Day Mortality.
Respiratory Tract Infections
Downregulation of miR?29b?3p promotes ??tubulin deacetylation by targeting the interaction of matrix metalloproteinase?9 with integrin ?1 in nasal polyps.
Use of MMP-8 and MMP-9 to assess disease severity in children with viral lower respiratory tract infections.
Retinal Detachment
Correlation of matrix metalloproteinase levels with the grade of proliferative vitreoretinopathy in the subretinal fluid and vitreous during rhegmatogenous retinal detachment.
Correlation of the extent and duration of rhegmatogenous retinal detachment with the expression of matrix metalloproteinases in the vitreous.
Expression of matrix metalloproteinases in the subretinal fluid correlates with the extent of rhegmatogenous retinal detachment.
The role and function of matrix metalloproteinase-8 in rhegmatogenous retinal detachment.
Retinal Diseases
The role and function of matrix metalloproteinase-8 in rhegmatogenous retinal detachment.
Retinal Hemorrhage
Insulin increases retinal hemorrhage in mild oxygen-induced retinopathy in the rat: inhibition by riluzole.
Retinal Neovascularization
ASSESSMENT OF GELATINASE AND TUMOR NECROSIS FACTOR-? LEVEL IN THE VITREOUS AND SERUM OF PATIENTS WITH EALES DISEASE: Role of Inflammation-Mediated Angiogenesis in the Pathogenesis of Eales Disease.
Connective tissue growth factor regulates retinal neovascularization through p53 protein-dependent transactivation of the matrix metalloproteinase (MMP)-2 gene.
Pharmacologic and genetic manipulation of MMP-2 and -9 affects retinal neovascularization in rodent models of OIR.
Regulation of matrix metalloproteinase expression by tumor necrosis factor in a murine model of retinal neovascularization.
Retinal neovascularization is suppressed with a matrix metalloproteinase inhibitor.
Synergism effect of swimming exercise and genistein on the inflammation, oxidative stress, and VEGF expression in the retina of diabetic-ovariectomized rats.
Retinal Vein Occlusion
Association of MMP2-1306C/T and TIMP2G-418C polymorphisms in retinal vein occlusion.
Retinoblastoma
Differential roles of matrix metalloproteinase-9 and -2, depending on proliferation or differentiation of retinoblastoma cells.
[Analysis of angiogenesis associated factors of retinoblastoma cell line and tumor tissues]
[Anti-sense nucleic acid of CyclinD1 induces apoptosis of lung adenocarcinoma cancer cell A549.]
Retinopathy of Prematurity
An interplay of microglia and matrix metalloproteinase MMP9 under hypoxic stress regulates the opticin expression in retina.
Pharmacologic and genetic manipulation of MMP-2 and -9 affects retinal neovascularization in rodent models of OIR.
Rhabdomyosarcoma
Fibronectin-induced COX-2 mediates MMP-2 expression and invasiveness of rhabdomyosarcoma.
Rheumatic Diseases
Association between Serum Matrix Metalloproteinase- (MMP-) 3 Levels and Systemic Lupus Erythematosus: A Meta-analysis.
Matrix metalloproteinase inhibitors in rheumatic diseases.
Matrix metalloproteinase knockout studies and the potential use of matrix metalloproteinase inhibitors in the rheumatic diseases.
Rheumatic Heart Disease
[Expression and significance of matrix metalloproteinase-1,9, tissue inhibitor of metalloproteinase-4 and extracellular matrix metalloproteinase inducer in the myocardium of congestive heart failure in patients with rheumatic heart diseases.]
[Role of anti-angiogenic factor chondromodulin-I for maintaining cardiac valvular function]
Rhinitis, Allergic
Nonasthmatic nasal polyposis patients with allergy exhibit greater epithelial MMP positivity.
Root Resorption
Expression of matrix metalloproteinases 2 and 9 in replanted teeth with external root resorption: A cross-sectional study.
Rosacea
Association of Rosacea With Risk for Glioma in a Danish Nationwide Cohort Study.
Elevated Expression and Activation of Matrix Metalloproteinase 8 in Tear Fluid in Atopic Blepharoconjunctivitis.
Exploring the Association Between Rosacea and Parkinson Disease: A Danish Nationwide Cohort Study.
Mast Cells Are Key Mediators of Cathelicidin-Initiated Skin Inflammation in Rosacea.
Salivary Gland Neoplasms
Matrix metalloproteinase (MMP)-1, -9 and -13 as prognostic factors in salivary gland cancer.
Matrix metalloproteinase (MMP)-7 in salivary gland cancer.
Sarcoidosis
Cytokine Signaling and Matrix Remodeling Pathways Associated with Cardiac Sarcoidosis Disease Activity Defined Using FDG PET Imaging.
Matrix metalloproteinases and tissue inhibitor of metalloproteinase-1 in sarcoidosis and IPF.
Sarcoma
A phase II and pharmacological study of the matrix metalloproteinase inhibitor (MMPI) COL-3 in patients with advanced soft tissue sarcomas.
Anticancer effects of a specific mixture of nutrients in the multidrug-resistant human uterine sarcoma MES-SA/Dx5 and the drug-sensitive MES-SA cell lines.
Clinicopathologic significance of fascin, extracellular matrix metalloproteinase inducer, and ezrin expressions in colorectal adenocarcinoma.
Effect of combined cyclooxygenase-2 and matrix metalloproteinase inhibition on human sarcoma xenografts.
Effects of genistein on invasion and matrix metalloproteinase activities of HT1080 human fibrosarcoma cells.
Expression of matrix metalloproteinases in feline vaccine site-associated sarcomas.
In vitro modulation of MMP-2 and MMP-9 in adult human sarcoma cell lines by cytokines, inducers and inhibitors.
In vitro modulation of MMP-2 and MMP-9 in pediatric human sarcoma cell lines by cytokines, inducers and inhibitors.
Local activity of matrix metalloproteinases in a case of botryoid sarcoma.
Matrix metalloproteinase expression in high grade soft tissue sarcomas.
Matrix metalloproteinases-1 and -8 improve the distribution and efficacy of an oncolytic virus.
Modulation of u-PA, MMPs and their inhibitors by a novel nutrient mixture in adult human sarcoma cell lines.
Modulation of u-PA, MMPs and their inhibitors by a novel nutrient mixture in pediatric human sarcoma cell lines.
Role of matrix metalloproteinase (MMP) 2 and MMP-9 in soft tissue sarcoma.
Sarcoma, Avian
Molecularly targeted therapy for gastrointestinal cancer.
Resolution of TIMP-free and TIMP-complexed 70kDa progelatinase from culture medium of Rous sarcoma virus-transformed chicken embryo fibroblasts.
Sarcoma, Ewing
Lack of matrix metalloproteinase (MMP)-1 and -3 expression in Ewing sarcoma may be due to loss of accessibility of the MMP regulatory element to the specific fusion protein in vivo.
Sarcoma, Kaposi
Matrix metalloproteinase inhibitor COL-3 in the treatment of AIDS-related Kaposi's sarcoma: a phase I AIDS malignancy consortium study.
Randomized phase II trial of matrix metalloproteinase inhibitor COL-3 in AIDS-related Kaposi's sarcoma: an AIDS Malignancy Consortium Study.
Scleroderma, Localized
Keratinocyte-derived cytokines after photodynamic therapy and their paracrine induction of matrix metalloproteinases in fibroblasts.
Scleroderma, Systemic
Domain 1 of the urokinase-type plasminogen activator receptor is required for its morphologic and functional, beta2 integrin-mediated connection with actin cytoskeleton in human microvascular endothelial cells: failure of association in systemic sclerosis endothelial cells.
Matrix metalloproteinase 12-dependent cleavage of urokinase receptor in systemic sclerosis microvascular endothelial cells results in impaired angiogenesis.
Matrix metalloproteinase gene polymorphisms and susceptibility to systemic sclerosis.
Scoliosis
Lack of Association Between the Promoter Polymorphisms of MMP-3 and IL-6 Genes and Adolescent Idiopathic Scoliosis: A Case-Control Study in a Chinese Han Population.
Seizures
Doxycycline could aggravate the absence-like epileptic seizures of WAG/Rij rats via matrix metalloproteinase inhibition.
Matrix metalloproteinase-7 regulates cleavage of pro-nerve growth factor and is neuroprotective following kainic acid-induced seizures.
The matrix metalloproteinase inhibitor marimastat inhibits seizures in a model of kainic acid-induced status epilepticus.
Seminoma
Extracellular matrix metalloproteinase inducer: a novel poor prognostic marker for human seminomas.
Sepsis
A novel role for matrix metalloproteinase-8 in sepsis.
Data-Independent Acquisition-Based Quantitative Proteomic Analysis Reveals Differences in Host Immune Response of Peripheral Blood Mononuclear Cells to Sepsis.
Discovery of Sulfated Small Molecule Inhibitors of Matrix Metalloproteinase-8.
Effects of bromopride on expression of metalloproteinases and interleukins in left colonic anastomoses: an experimental study.
Elevated plasma matrix metalloproteinases and their tissue inhibitors in patients with severe sepsis.
Infiltration of inflammatory cells plays an important role in matrix metalloproteinase expression and activation in the heart during sepsis.
Intestine-Derived Matrix Metalloproteinase-8 Is a Critical Mediator of Polymicrobial Peritonitis.
LL-37 Exacerbates Local Inflammation in Sepsis-Induced Acute Lung Injury by Preventing Mitochondrial DNA (mtDNA) Degradation-Induced Autophagy.
Loss of matrix metalloproteinase-8 is associated with worsened recovery after ischemic kidney injury.
Matrix metalloproteinase MMP-8, TIMP-1 and MMP-8/TIMP-1 ratio in plasma in methicillin-sensitive Staphylococcus aureus bacteremia.
Matrix Metalloproteinase-2 and Metalloproteinase-9 Activities are Associated with Blood-Brain Barrier Dysfunction in an Animal Model of Severe Sepsis.
Matrix metalloproteinase-8 as a potential drug target for the therapy of sepsis.
Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile Sepsis Model.
Matrix metalloproteinases -8 and -9 and tissue inhibitor of metalloproteinase-1 in burn patients. A prospective observational study.
Matrix metalloproteinases and their inhibitors: promising novel biomarkers in severe sepsis?
Platelet shedding of CD40L is regulated by matrix metalloproteinase-9 in abdominal sepsis.
Role of plasma matrix-metalloproteases (MMPs) and their polymorphisms (SNPs) in sepsis development and outcome in ICU patients.
Second Generation Triple-Helical Peptide Inhibitors of Matrix Metalloproteinases.
Serum MMP-8, -9 and TIMP-1 in sepsis: High serum levels of MMP-8 and TIMP-1 are associated with fatal outcome in a multicentre, prospective cohort study. Hypothetical impact of tetracyclines.
Simultaneous Inhibition of Tumor Necrosis Factor Receptor 1 and Matrix Metalloproteinase 8 Completely Protects Against Acute Inflammation and Sepsis.
Systemic matrix metalloproteinase-8 and tissue inhibitor of metalloproteinases-1 levels in severe sepsis-associated coagulopathy.
Targeting matrix metalloproteinases with intravenous doxycycline in severe sepsis--A randomised placebo-controlled pilot trial.
Zinc dyshomeostasis during polymicrobial sepsis in mice involves zinc transporter Zip14 and can be overcome by zinc supplementation.
Severe Combined Immunodeficiency
Expression of MTAP inhibits tumor-related phenotypes in HT1080 cells via a mechanism unrelated to its enzymatic function.
Role of the matrix metalloproteinase and tissue inhibitors of metalloproteinase families in noninvasive and invasive tumors transplanted in mice with severe combined immunodeficiency.
Shock, Cardiogenic
High serum matrix metalloproteinase-9 level predict increased risk of in-hospital cardiac events in patients with type 2 diabetes and ST segment elevation myocardial infarction.
Shock, Septic
A novel role for matrix metalloproteinase-8 in sepsis.
Effect of a matrix metalloproteinase inhibitor on host resistance against Listeria monocytogenes infection.
Inhibition of Neutrophil Collagenase/MMP-8 and Gelatinase B/MMP-9 and Protection against Endotoxin Shock.
Targeting matrix metalloproteinases with intravenous doxycycline in severe sepsis--A randomised placebo-controlled pilot trial.
Targeting neutrophil collagenase/matrix metalloproteinase-8 and gelatinase B/matrix metalloproteinase-9 with a peptidomimetic inhibitor protects against endotoxin shock.
Silicosis
Tumor necrosis factor receptor deficiency alters matrix metalloproteinase 13/tissue inhibitor of metalloproteinase 1 expression in murine silicosis.
Sinus Thrombosis, Intracranial
Polymorphism in dural arteriovenous fistula: matrix metalloproteinase-2-1306 C/T as a potential risk factor for sinus thrombosis.
Skin Neoplasms
Diet-induced obesity and reduced skin cancer susceptibility in matrix metalloproteinase 19-deficient mice.
Differential expression of matrix metalloproteinase (MMP)-2, MMP-9 and tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 in non-melanoma skin cancer: implications for tumour progression.
Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8).
Matrilysin-1 (MMP-7) and MMP-19 are expressed by Paget's cells in extramammary Paget's disease.
Matrix metalloproteinase-2 and -9 expression increases in Mycoplasma-infected airways but is not required for microvascular remodeling.
Missense polymorphisms in matrix metalloproteinase genes and skin cancer risk.
[Expression and significance of matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase in non-melanoma skin cancer].
Sleep Apnea, Obstructive
Matrix metalloproteinase 9 (MMP9) level and MMP9 -1562C>T in patients with obstructive sleep apnea: a systematic review and meta-analysis of case-control studies.
Small Cell Lung Carcinoma
Redox regulation of matrix metalloproteinase gene family in small cell lung cancer cells.
Small cell lung cancer and targeted therapies.
Strategies to eradicate minimal residual disease in small cell lung cancer: high-dose chemotherapy with autologous bone marrow transplantation, matrix metalloproteinase inhibitors, and BEC2 plus BCG vaccination.
Transition from suspension to adherent growth is accompanied by tissue factor expression and matrix metalloproteinase secretion in a small cell lung cancer cell line.
Soft Tissue Neoplasms
Matrix metalloproteinase expression is related to angiogenesis and histologic grade in spindle cell soft tissue neoplasms of the extremities.
Spinal Cord Injuries
CB1 cannabinoid receptor agonist inhibits matrix metalloproteinase activity in spinal cord injury: A possible mechanism of improved recovery.
Efficacy of a metalloproteinase inhibitor in spinal cord injured dogs.
Exploratory study to suggest the possibility of MMP-8 and MMP-9 serum levels as early markers for remission after traumatic spinal cord injury.
Expression of MMP-8 in Pressure Injuries in Spinal Cord Injury Patients Managed by Negative Pressure Wound Therapy or Conventional Wound Care: A Randomized Controlled Trial.
Glucocorticoid receptor-mediated suppression of activator protein-1 activation and matrix metalloproteinase expression after spinal cord injury.
Matrix Metalloproteinase-8 Inhibition Prevents Disruption of Blood-Spinal Cord Barrier and Attenuates Inflammation in Rat Model of Spinal Cord Injury.
Multiplex array proteomics detects increased MMP-8 in CSF after spinal cord injury.
Selective Inhibition of MMP-2 Does Not Alter Neurological Recovery after Spinal Cord Injury.
Type IV collagen and its degradation in paralyzed human muscle: effect of functional electrical stimulation.
Spondylarthropathies
Matrix metalloproteinase expression in the spondyloarthropathies.
Spondylitis, Ankylosing
Association of cytokine and matrix metalloproteinase profiles with disease activity and function in ankylosing spondylitis.
Investigation of two novel biochemical markers of inflammation, matrix metalloproteinase and cathepsin generated fragments of C-reactive protein, in patients with ankylosing spondylitis.
MicroRNA let-7i-3p affects osteoblast differentiation in ankylosing spondylitis via targeting PDK1.
MMP-2 silencing reduces the osteogenic transformation of fibroblasts by inhibiting the activation of the BMP/Smad pathway in ankylosing spondylitis.
MMP-8 single-nucleotide polymorphisms are related to ankylosing spondylitis in Chinese Han population.
Spondylosis
[Effects of Chiropractics on Intervertebral Disk Extracell Matrix and Metabolic Enzymes in Rats with Cervical Spondylosis].
Squamous Cell Carcinoma of Head and Neck
A circular RNA derived from MMP9 facilitates oral squamous cell carcinoma metastasis through regulation of MMP9 mRNA stability.
Acid-electrolyzed functional water induces extracellular matrix metalloproteinase inducer, a possible novel alarmin, secretion from oral squamous cell carcinoma cell lines.
ADAM17-mediated CD44 cleavage promotes orasphere formation or stemness and tumorigenesis in HNSCC.
Alpha-mangostin suppresses MMP-2 and MMP-9 expression in head and neck squamous carcinoma cells.
Anticancer Efficacy of Polyphenols and Their Combinations.
Association of CD44 V3-containing isoforms with tumor cell growth, migration, matrix metalloproteinase expression, and lymph node metastasis in head and neck cancer.
Association of matrix metalloproteinase (MMP)-1 promoter polymorphism with head and neck squamous cell carcinoma.
Circulating 92-kilodalton matrix metalloproteinase (MMP-9) activity is enhanced in the euglobulin plasma fraction of head and neck squamous cell carcinoma.
Correlation of matrix metalloproteinase-2, -9, tissue inhibitor-1 of matrix metalloproteinase and CD44 variant 6 in head and neck cancer metastasis.
DSPP-MMP20 gene silencing downregulates cancer stem cell markers in human oral cancer cells.
Effects of cytokines on matrix metalloproteinase expression in oral squamous cell carcinoma in vitro.
EMMPRIN expression in oral SCC is regulated by FYN kinase.
EMMPRIN expression in oral squamous cell carcinomas: correlation with tumor proliferation and patient survival.
Estimation of serum and salivary matrix metalloproteinase levels in oral squamous cell carcinoma patients: a systematic review and meta-analysis.
Expression and regulation of collagenase-2 (MMP-8) in head and neck squamous cell carcinomas.
Expression of FLJ10540 is correlated with aggressiveness of oral cavity squamous cell carcinoma by stimulating cell migration and invasion through increased FOXM1 and MMP-2 activity.
Expression of invasion markers CD44v6/v3, NM23 and MMP2 in laryngeal and hypopharyngeal carcinoma.
Expression of matrix metalloproteinase 1, matrix metalloproteinase 2, and matrix metalloproteinase 9 in carcinoma of the head and neck.
Extracellular matrix metalloproteinase inducer expression in histological grades of oral squamous cell carcinoma - An immunohistochemical study.
Fusobacteria modulate oral carcinogenesis and promote cancer progression.
Hepatocyte growth factor upregulates E1AF that induces oral squamous cell carcinoma cell invasion by activating matrix metalloproteinase genes.
High expression levels of nuclear factor kappa B and gelatinases in the tumorigenesis of oral squamous cell carcinoma.
Human neutrophil peptide-1 affects matrix metalloproteinase-2, -8 and -9 secretions of oral squamous cell carcinoma cell lines in vitro.
IFN-induced transmembrane protein 1 promotes invasion at early stage of head and neck cancer progression.
Imatinib-associated matrix metalloproteinase suppression in p16-positive squamous cell carcinoma compared to HPV-negative HNSCC cells in vitro.
Immunohistochemical expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma.
Immunohistochemical expression of MMP-2 and MMP-8 in oral squamous cell carcinoma.
Increased stromelysin 3 gene expression is associated with increased local invasiveness in head and neck squamous cell carcinomas.
Matrix metalloproteinase (MMP) and immunosuppressive biomarker profiles of seven head and neck squamous cell carcinoma (HNSCC) cell lines.
Matrix metalloproteinase (MMP)-2 and MMP-9 polymorphisms and haplotypes as disease biomarkers.
Matrix metalloproteinase-2 and -9 activities correlate with the disease-free survival of oral squamous cell carcinoma patients.
Membrane type I-matrix metalloproteinase-mediated degradation of type I collagen by oral squamous cell carcinoma cells.
MMPs, TIMP-2, and TGF-beta1 in the cancerization of oral lichen planus.
Molecular docking of alkaloid compounds with the matrix metalloproteinase 2.
MT4-MMP promotes invadopodia formation and cell motility in FaDu head and neck cancer cells.
PKM2 enhances cancer invasion via ETS-1-dependent induction of matrix metalloproteinase in oral squamous cell carcinoma cells.
Plasma level of tissue inhibitor of matrix metalloproteinase-1 but not that of matrix metalloproteinase-8 predicts survival in head and neck squamous cell cancer.
Prognostic significance of matrix metalloproteinase-20 overexpression in laryngeal squamous cell carcinoma.
Rap1GAP promotes invasion via induction of matrix metalloproteinase 9 secretion, which is associated with poor survival in low N-stage squamous cell carcinoma.
Reduction of hyaluronan-CD44-mediated growth, migration, and cisplatin resistance in head and neck cancer due to inhibition of Rho kinase and PI-3 kinase signaling.
Relationship between the Expression of Matrix Metalloproteinase and Clinicopathologic Features in Oral Squamous Cell Carcinoma.
Serum matrix metalloproteinase 8 and tissue inhibitor of metalloproteinase 1: Potential markers for malignant transformation of recurrent respiratory papillomatosis and for prognosis of laryngeal cancer.
The effect of hypoxic microenvironment on matrix metalloproteinase expression in xenografts of human oral squamous cell carcinoma.
The immunohistochemical characterization of MMP-2, MMP-10, TIMP-1, TIMP-2, and podoplanin in oral squamous cell carcinoma.
The interplay of matrix metalloproteinase-8, transforming growth factor-?1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma.
The matrix metalloproteinase system in oral squamous cell carcinoma.
Tight junction protein claudin-1 enhances the invasive activity of oral squamous cell carcinoma cells by promoting cleavage of laminin-5 gamma2 chain via matrix metalloproteinase (MMP)-2 and membrane-type MMP-1.
Tumor and salivary matrix metalloproteinase levels are strong diagnostic markers of oral squamous cell carcinoma.
Ultrasound-guided intratumoral administration of collagenase-2 improved liposome drug accumulation in solid tumor xenografts.
[Correlation of membrane type I matrix metalloproteinase (MT1-MMP) expression with clinicomorphological features of tumor front in squamous cell carcinoma of the larynx]
[Expression of extracellular matrix metalloproteinase inducer in laryngeal squamous cell carcinoma]
[Relationship between expression of MMP-2 and prognosis in human laryngeal squamous cell carcinoma].
ST Elevation Myocardial Infarction
Relation of nocturnal melatonin levels to serum matrix metalloproteinase-9 concentrations in patients with myocardial infarction.
Status Asthmaticus
Contribution of 92 kDa gelatinase/type IV collagenase in bronchial inflammation during status asthmaticus.
Status Epilepticus
Increased metalloproteinase activity in the hippocampus following status epilepticus.
The matrix metalloproteinase inhibitor marimastat inhibits seizures in a model of kainic acid-induced status epilepticus.
Stevens-Johnson Syndrome
Neutrophil Collagenase, Gelatinase, and Myeloperoxidase in Tears of Patients with Stevens-Johnson Syndrome and Ocular Cicatricial Pemphigoid.
Stomach Neoplasms
A pilot study of the safety and effects of the matrix metalloproteinase inhibitor marimastat in gastric cancer.
Apoptosis-promoting and migration-suppressing effect of alantolactone on gastric cancer cell lines BGC-823 and SGC-7901 via regulating p38MAPK and NF-?B pathways.
Baicalein inhibits the invasion of gastric cancer cells by suppressing the activity of the p38 signaling pathway.
beta-Catenin/Wnt signaling regulates expression of the membrane type 3 matrix metalloproteinase in gastric cancer.
Clinical and experimental role of ring finger protein 180 on lymph node metastasis and survival in gastric cancer.
Clinical Impact of MMP and TIMP Gene Polymorphisms in Gastric Cancer.
Effect and prognostic significance of the KAI1 gene in human gastric carcinoma.
Effect of a matrix metalloproteinase inhibitor on a lymph node metastatic model of gastric cancer cells passaged by orthotopic implantation.
Effect of BRMS1 expression on proliferation, migration and adhesion of mouse forestomach carcinoma.
Effect of glutamine-enriched nutritional support on intestinal mucosal barrier function, MMP-2, MMP-9 and immune function in patients with advanced gastric cancer during perioperative chemotherapy.
Eicosapentaenoic acid and docosahexaenoic acid inhibit macrophage-induced gastric cancer cell migration by attenuating the expression of matrix metalloproteinase 10.
Expression and clinical significance of matrix metalloproteinase-17 and -25 in gastric cancer.
Expression of activated signal transducer and activator of transcription 3 predicts poor clinical outcome in gastric adenocarcinoma.
Expression of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) as a prognostic indicator in gastric cancer.
HOXC6 promotes gastric cancer cell invasion by upregulating the expression of MMP9.
Inhibition of MMP activity can restore NKG2D ligand expression in gastric cancer, leading to improved NK cell susceptibility.
Matrix metalloproteinase expression and molecular interaction network analysis in gastric cancer.
Matrix metalloproteinase gene expressions might be oxidative stress targets in gastric cancer cell lines.
Matrix metalloproteinase-2 is a consistent prognostic factor in gastric cancer.
Metastatic function of BMP-2 in gastric cancer cells: the role of PI3K/AKT, MAPK, the NF-?B pathway, and MMP-9 expression.
miRNA-145 Targets v-ets Erythroblastosis Virus E26 Oncogene Homolog 1 to Suppress the Invasion, Metastasis, and Angiogenesis of Gastric Cancer Cells.
MMP-2 as a putative biomarker for carcinomatosis in gastric cancer.
p75 neurotrophin receptor inhibits invasion and metastasis of gastric cancer.
Paclitaxel combined with harmine inhibits the migration and invasion of gastric cancer cells through downregulation of cyclooxygenase-2 expression.
Paeonol exerts potential activities to inhibit the growth, migration and invasion of human gastric cancer BGC823 cells via downregulating MMP?2 and MMP?9.
Preventive effect of matrix metalloproteinase inhibitor, R-94138, in combination with mitomycin C or cisplatin on peritoneal dissemination of human gastric cancer cell line TMK-1 in nude mice.
Redox state of adipose tissue for patients with gastric cancer and its connection with the body mass index and distance from the tumor.
Reduced angiogenesis in peritoneal dissemination of gastric cancer through gelatinase inhibition.
Role of serum matrix metalloproteinase in the diagnosis of gastric cancer.
Serpin peptidase inhibitor clade A member 1 is a biomarker of poor prognosis in gastric cancer.
Serum MMP-8 and TIMP-1 as prognostic biomarkers in gastric cancer.
SPARC is associated with gastric cancer progression and poor survival of patients.
The influence of transforming growth factor-?, cyclooxygenase-2, matrix metalloproteinase (MMP)-7, MMP-9 and CXCR4 proteins involved in epithelial-mesenchymal transition on overall survival of patients with gastric cancer.
Tissue inhibitor of metalloproteinase 1 is a negative regulator of the metastatic ability of a human gastric cancer cell line, KKLS, in the chick embryo.
Upregulated Expression of ADAM17 Is a Prognostic Marker for Patients With Gastric Cancer.
Upregulation of circulating cytokeratin 20, urokinase plasminogen activator and C-reactive protein is associated with poor prognosis in gastric cancer.
[Antitumor effect of a matrix metalloproteinase inhibitor, TA-2516 (Marimastat), on a nude mouse model of intraperitoneal seeding of stomach cancer]
[Therapeutic effect of matrix metalloproteinase inhibitor (R-94138) for peritoneal metastasis of stomach neoplasm models]
Stomach Ulcer
Genetic variants in matrix metalloproteinase genes are associated with development of gastric ulcer in H. Pylori infection.
Increased expression of matrix metalloproteinase-9 associated with gastric ulcer recurrence.
Matrix metalloproteinase gene expression in chronic gastric ulcer: a potential role of eosinophils in perforation.
Stomatitis, Aphthous
Clinical assessment of the effect of a matrix metalloproteinase inhibitor on aphthous ulcers.
Effect of tetracyclines on collagenase activity in patients with recurrent aphthous ulcers.
Stroke
A Lipoxin A(4) Analog Ameliorates Blood-Brain Barrier Dysfunction and Reduces MMP-9 Expression in a Rat Model of Focal Cerebral Ischemia-Reperfusion Injury.
A matrix metalloproteinase protein array reveals a strong relation between MMP-9 and MMP-13 with diffusion-weighted image lesion increase in human stroke.
Annexin A2 Plus Low-Dose Tissue Plasminogen Activator Combination Attenuates Cerebrovascular Dysfunction After Focal Embolic Stroke of Rats.
Anti-arrhythmic and anti-heart failure effects of low-level electrical stimulation on aortic root ventricular ganglionated plexi.
Apolipoprotein A-I and Paraoxonase-1 Are Potential Blood Biomarkers for Ischemic Stroke Diagnosis.
Association of tumor necrosis factor-? and matrix metalloproteinase-3 gene variants with stroke.
Atorvastatin downregulates tissue plasminogen activator-aggravated genes mediating coagulation and vascular permeability in single cerebral endothelial cells captured by laser microdissection.
Biomarkers of periodontitis and inflammation in ischemic stroke: A case-control study.
Candesartan reduces the hemorrhage associated with delayed tissue plasminogen activator treatment in rat embolic stroke.
Carotid atherosclerotic plaques in patients with transient ischemic attacks and stroke have unstable characteristics compared with plaques in asymptomatic and amaurosis fugax patients.
Causal associations of serum matrix metalloproteinase-8 level with ischaemic stroke and ischaemic stroke subtypes: a Mendelian randomization study.
Chronic systemic infection exacerbates ischemic brain damage via a CCL5 (regulated on activation, normal T-cell expressed and secreted)-mediated proinflammatory response in mice.
Circulating biomarkers of extracellular matrix remodeling and risk of atherosclerotic events.
Combination of endothelial progenitor cells and BB-94 significantly alleviates brain damage in a mouse model of diabetic ischemic stroke.
Connective Tissue Growth Factor Is Associated With a Stable Atherosclerotic Plaque Phenotype and Is Involved in Plaque Stabilization After Stroke.
Delayed Gelatinase Inhibition Induces Reticulon 4 Receptor Expression in the Peri-Infarct Cortex.
Delayed matrix metalloproteinase inhibition reduces intracerebral hemorrhage after embolic stroke in rats.
Differential matrix metalloproteinase expression in cases of multiple sclerosis and stroke.
Dipyridamole decreases inflammatory metalloproteinase-9 expression and release by human monocytes.
Early beneficial effect of matrix metalloproteinase inhibition on blood-brain barrier permeability as measured by magnetic resonance imaging countered by impaired long-term recovery after stroke in rat brain.
Endothelium-targeted pharmacotherapeutics for the treatment of stroke.
Fisetin Prolongs Therapy Window of Brain Ischemic Stroke Using Tissue Plasminogen Activator: A Double-Blind Randomized Placebo-Controlled Clinical Trial.
Ginsenoside Represses Symptomatic Intracerebral Hemorrhage after Recombinant Tissue Plasminogen Activator Therapy by Promoting Transforming Growth Factor-?1.
Increased plasma and tissue MMP levels are associated with BCSFB and BBB disruption evident on post-contrast FLAIR after experimental stroke.
Inhibition of Gelatinases (MMP-2 and MMP-9) by Withania somnifera Phytochemicals Confers Neuroprotection in Stroke: An In Silico Analysis.
Involvement of matrix metalloproteinase in neuroblast cell migration from the subventricular zone after stroke.
Matrix metalloproteinase (MMP) induction and inhibition at different doses of recombinant tissue plasminogen activator following experimental stroke.
Matrix metalloproteinase and cytokine profiles in monocytes over the course of stroke.
Matrix metalloproteinase inhibition counteracts impairment of cortical experience-dependent plasticity after photothrombotic stroke.
Matrix metalloproteinase inhibition in atherosclerosis and stroke.
Matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 predict incident cardiovascular disease events and all-cause mortality in a population-based cohort.
Matrix metalloproteinases and atherosclerotic plaque instability.
Mechanisms of hemorrhagic transformation after tissue plasminogen activator reperfusion therapy for ischemic stroke.
Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke.
Pre-ischemic exercise reduces matrix metalloproteinase-9 expression and ameliorates blood-brain barrier dysfunction in stroke.
Reduced brain edema and matrix metalloproteinase (MMP) expression by pre-reperfusion infusion into ischemic territory in rat.
Reperfusion and Neurovascular Dysfunction in Stroke: from Basic Mechanisms to Potential Strategies for Neuroprotection.
Selective MMP-inhibition with Ro 28-2653 in acute experimental stroke - a magnetic resonance imaging efficacy study.
Serum matrix metalloproteinase-8, tissue inhibitor of metalloproteinase and myeloperoxidase in ischemic stroke.
Serum tissue-degrading proteinases and incident cardiovascular disease events.
Sonographic monitoring of mass effect in stroke patients treated with hypothermia. Correlation with intracranial pressure and matrix metalloproteinase 2 and 9 expression.
Stroke Induces Mesenchymal Stem Cell Migration to Infarcted Brain Areas Via CXCR4 and C-Met Signaling.
The expression of matrix metalloproteinase-13 is increased in vessels with blood-brain barrier impairment in a stroke-prone hypertensive model.
The URICO-ICTUS study, a phase 3 study of combined treatment with uric acid and rtPA administered intravenously in acute ischaemic stroke patients within the first 4.5 h of onset of symptoms.
Translating Koch's postulates to identify matrix metalloproteinase roles in postmyocardial infarction remodeling: cardiac metalloproteinase actions (CarMA) postulates.
True Effects or Bias? MMP-2 and MMP-9 Serum Concentrations after Acute Stroke.
Tumor necrosis factor-alpha neutralization reduced cerebral edema through inhibition of matrix metalloproteinase production after transient focal cerebral ischemia.
White Matter Hyperintensity Volume Correlates with Matrix Metalloproteinase-2 in Acute Ischemic Stroke.
stromelysin 1 deficiency
Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response.
Subarachnoid Hemorrhage
Effects of recombinant osteopontin on blood-brain barrier disruption after subarachnoid hemorrhage in rats.
Subdural Effusion
[Role of matrix metalloproteinase in transformation of subdural effusion into chronic subdural hematoma]
Suppuration
Biological response to peri-implantitis treatment.
Synovitis
Changes in MMP-2 and -9 activity and MMP-8 reactivity after amphotericin B induced synovitis and treatment with bufexamac.
Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction.
Effects of knockout of the receptor for advanced glycation end-products on bone mineral density and synovitis in mice with intra-articular fractures.
In vivo effects of meloxicam on inflammatory mediators, MMP activity and cartilage biomarkers in equine joints with acute synovitis.
In vivo effects of phenylbutazone on inflammation and cartilage-derived biomarkers in equine joints with acute synovitis.
Pathological features of established osteoarthritis with hydrathrosis are similar to rheumatoid arthritis.
Synovitis, Pigmented Villonodular
Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction.
Syphilis
Expression of matrix metalloproteinases and their tissue inhibitors in the serum and cerebrospinal fluid of patients with HIV-1 infection and syphilis or neurosyphilis.
Telangiectasia, Hereditary Hemorrhagic
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Telangiectasis
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Temporomandibular Joint Disorders
Expression of collagenases (matrix metalloproteinase-1, 8, 13) and tissue inhibitor of metalloproteinase-1 of retrodiscal tissue in temporomandibular joint disorder patients.
Matrix metalloproteinase and tissue inhibitor of metalloproteinase in serum and lavage synovial fluid of patients with temporomandibular joint disorders.
Tendinopathy
Active expression of matrix metalloproteinase-13 mRNA in the granulation tissue of equine superficial digital flexor tendinitis.
Association of MMP-8 polymorphisms with tendinopathy of the primary posterior tibial tendon: a pilot study.
Efficacy of Combining PRP and MMP Inhibitors in Treating Moderately Damaged Tendons Ex Vivo.
Further characterisation of an experimental model of tendinopathy in the horse.
High-molecular-weight hyaluronic acid attenuated matrix metalloproteinase-1 and -3 expression via CD44 in tendinopathy.
Inhibition of CD44 induces apoptosis, inflammation, and matrix metalloproteinase expression in tendinopathy.
Matrix metalloproteinase inhibitors prevent a decrease in the mechanical properties of stress-deprived tendons: an in vitro experimental study.
MMP-8 polymorphism is genetic marker to tendinopathy primary posterior tibial tendon.
Photobiomodulation therapy on collagen type I and III, vascular endothelial growth factor, and metalloproteinase in experimentally induced tendinopathy in aged rats.
Preclinical and clinical studies of MMP inhibitors in cancer.
Statin treatment increases the clinical risk of tendinopathy through matrix metalloproteinase release - a cohort study design combined with an experimental study.
Successful management of tendinopathy with injections of the MMP-inhibitor aprotinin.
Tendinosis: pathophysiology and nonoperative treatment.
TOL19-001 reduces inflammation and MMP expression in monolayer cultures of tendon cells.
Teratoma
Tissue inhibitor of metalloproteinase proteins inhibit teratoma growth in mice transplanted with pluripotent stem cells.
Thrombocytosis
Platelets prevent the development of monocrotaline-induced liver injury in mice.
Thrombosis
Breaking symmetry in protein dimers: designs and functions.
Crucial Involvement of IL-6 in Thrombus Resolution in Mice via Macrophage Recruitment and the Induction of Proteolytic Enzymes.
Edoxaban improves venous thrombosis via increasing hydrogen sulfide and homocysteine in rat model.
Enhanced matrix-degrading proteolytic activity within the thin thrombus-covered wall of human abdominal aortic aneurysms.
Enhanced T-cell expression of RANK ligand in acute coronary syndrome: possible role in plaque destabilization.
Expression changes and roles of matrix metalloproteinases in a rat model of traumatic deep vein thrombosis.
Granulocytes in coronary thrombus evolution after myocardial infarction - time-dependent changes in expression of matrix metalloproteinases.
Matrix metalloproteinase-10 effectively reduces infarct size in experimental stroke by enhancing fibrinolysis via a thrombin-activatable fibrinolysis inhibitor-mediated mechanism.
Matrix Metalloproteinase-13 Predominates Over Matrix Metalloproteinase-8 as the Functional Interstitial Collagenase in Mouse Atheromata.
Plasminogen activator-1 overexpression decreases experimental postthrombotic vein wall fibrosis by a non-vitronectin-dependent mechanism.
Recanalization and flow regulate venous thrombus resolution and matrix metalloproteinase expression in vivo.
Rivaroxaban attenuates thrombosis by targeting the NF-?B signaling pathway in a rat model of deep venous thrombus.
Specialized regulatory T cells control venous blood clot resolution through SPARC.
Thrombosed arteriovenous fistula for hemodialysis access is characterized by a marked inflammatory activity.
Thymoma
Activation of matrix metalloproteinase-2 is correlated with invasiveness in thymic epithelial tumors.
Analysis of salivary microRNA expression profiles and identification of novel biomarkers in esophageal cancer.
Clinical significance of tissue inhibitor of metalloproteinase and matrix metalloproteinase mRNA expression in thymoma.
Thyroid Cancer, Papillary
Clinical value of matrix metalloproteinase-2 and -9 in ultrasound-guided radiofrequency ablation treatment for papillary thyroid carcinoma.
EMMPRIN (CD147) expression and differentiation of papillary thyroid carcinoma: implications for immunocytochemistry in FNA cytology.
Immunohistochemical levels of cyclo-oxygenase-2, matrix metalloproteinase-9 and vascular endothelial growth factor in papillary thyroid carcinoma and their clinicopathological correlations.
Immunohistochemical levels of matrix metalloproteinase-2 and CD44 variant 6 protein in the diagnosis and lateral cervical lymph node metastasis of papillary thyroid carcinoma.
Study on extracellular matrix metalloproteinase inducer and human epidermal growth factor receptor-2 protein expression in papillary thyroid carcinoma using a quantum dot-based immunofluorescence technique.
Thyroid Carcinoma, Anaplastic
Combining a matrix metalloproteinase inhibitor, a farnesyltransferase inhibitor, and a taxane improves survival in an anaplastic thyroid cancer model.
Thyroid Neoplasms
Analysis of ALK, IDH1, IDH2 and MMP8 somatic mutations in differentiated thyroid cancers.
Comparative analysis of protein expression in differentiated thyroid tumours: a multicentre study.
Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A.
Human thyroid carcinoma cell lines and normal thyrocytes: expression and regulation of matrix metalloproteinase-1 and tissue matrix metalloproteinase inhibitor-1 messenger-RNA and protein.
Matrix metalloproteinase (MMP) expression by differentiated thyroid carcinoma of children and adolescents.
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in thyroid C-cells and medullary thyroid carcinomas.
Modulation of matrix metalloproteinase activity in human thyroid cancer cell lines using demethylating agents and histone deacetylase inhibitors.
Mutational analysis of the GNA11, MMP27, FGD1, TRRAP and GRM3 genes in thyroid cancer.
[Clinical significance of functional variants of matrix metalloproteinase genes in thyroid cancer]
Tongue Neoplasms
Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer.
Plasma level of tissue inhibitor of matrix metalloproteinase-1 but not that of matrix metalloproteinase-8 predicts survival in head and neck squamous cell cancer.
The interplay of matrix metalloproteinase-8, transforming growth factor-?1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma.
Tonsillitis
Systemic matrix metalloproteinase-8 response in chronic tonsillitis.
Tooth Mobility
Periodontal disease may induce liver fibrosis in an experimental study on Wistar rats.
Tooth, Nonvital
Matrix metalloproteinase-8 and substance P levels in gingival crevicular fluid during endodontic treatment of painful, nonvital teeth.
Toxocariasis
Matrix metalloproteinase-2 and matrix metalloproteinase-9 in mice with ocular toxocariasis.
Toxoplasmosis
Induction of matrix metalloproteinase-2 and -9 via Erk1/2-NF-?B pathway in human astroglia infected with Toxoplasma gondii.
Trichiasis
Conjunctival expression of matrix metalloproteinase and pro-inflammatory cytokine genes following trichiasis surgery.
Doxycycline prevents matrix remodeling and contraction by trichiasis-derived conjunctival fibroblasts.
Trichinellosis
Matrix metalloproteinase (MMP)-9: A realiable marker for inflammation in early human trichinellosis.
Triple Negative Breast Neoplasms
A novel regulatory function of CDKN1A/p21 in TNF?-induced matrix metalloproteinase 9-dependent migration and invasion of triple-negative breast cancer cells.
c-Abl inhibits breast cancer tumorigenesis through reactivation of p53-mediated p21 expression.
Corrigendum to 'A novel regulatory function of CDKN1A/p21 in TNF?-induced matrix metalloproteinase 9-dependent migration and invasion of triple-negative breast cancer cells' cellular signalling, volume 47, July 2018, Pages 27-36.
Docosahexaenoic acid suppresses migration of triple-negative breast cancer cell through targeting metastasis-related genes and microRNA under normoxic and hypoxic conditions.
Predictive and prognostic value of Matrix metalloproteinase (MMP) - 9 in neoadjuvant chemotherapy for triple-negative breast cancer patients.
Tuberculoma
DTI derived indices correlate with immunohistochemistry obtained matrix metalloproteinase (MMP-9) expression in cellular fraction of brain tuberculoma.
Tuberculosis
A matrix metalloproteinase inhibitor promotes granuloma formation during the early phase of Mycobacterium tuberculosis pulmonary infection.
Adjunct antibody administration with standard treatment reduces relapse rates in a murine tuberculosis model of necrotic granulomas.
Alternative activation deprives macrophages of a coordinated defense program to Mycobacterium tuberculosis.
Batimastat reduces Mycobacterium tuberculosis-induced apoptosis in macrophages.
Biomarkers of Tuberculosis Severity and Treatment Effect: A Directed Screen of 70 Host Markers in a Randomized Clinical Trial.
Differential regulation of MMP-1/9 and TIMP-1 secretion in human monocytic cells in response to Mycobacterium tuberculosis.
Doxycycline and HIV Infection Suppress Tuberculosis-induced Matrix Metalloproteinases.
Host gene-encoded severe lung TB: from genes to the potential pathways.
In an in vitro model of human tuberculosis, monocyte-microglial networks regulate matrix metalloproteinase-1 and -3 gene expression and secretion via a p38 mitogen activated protein kinase-dependent pathway.
Matrix Metalloproteinase Inhibition in a Murine Model of Cavitary Tuberculosis Paradoxically Worsens Pathology.
Matrix metalloproteinase inhibitors enhance the efficacy of frontline drugs against Mycobacterium tuberculosis.
Matrix metalloproteinase proteolysis of the mycobacterial HSP65 protein as a potential source of immunogenic peptides in human tuberculosis.
Monocyte-astrocyte networks regulate matrix metalloproteinase gene expression and secretion in central nervous system tuberculosis in vitro and in vivo.
Procollagen III N-terminal Propeptide and Desmosine are Released by Matrix Destruction in Pulmonary Tuberculosis.
Regulation of matrix metalloproteinase-1, -3, and -9 in Mycobacterium tuberculosis-dependent respiratory networks by the rapamycin-sensitive PI3K/p70S6K cascade.
Unopposed matrix metalloproteinase-9 expression in human tuberculous granuloma and the role of TNF-alpha-dependent monocyte networks.
[The system of matrix metalloproteinases and their role in patients with pulmonary tuberculosis].
Tuberculosis, Central Nervous System
Monocyte-astrocyte networks regulate matrix metalloproteinase gene expression and secretion in central nervous system tuberculosis in vitro and in vivo.
Tuberculosis, Meningeal
Cerebrospinal fluid cytokines and matrix metalloproteinases in human immunodeficiency seropositive and seronegative patients of tuberculous meningitis.
Dexamethasone, cerebrospinal fluid matrix metalloproteinase concentrations and clinical outcomes in tuberculous meningitis.
Elevated Matrix Metalloproteinase Concentrations Offer Novel Insight Into Their Role in Pediatric Tuberculous Meningitis.
Persistent increase of matrix metalloproteinases in cerebrospinal fluid of tuberculous meningitis.
Title: role of matrix metalloproteinase -9 in progression of tuberculous meningitis: a pilot study in patients at different stages of the disease.
Tuberculosis, Pulmonary
Association of Plasma Matrix Metalloproteinase and Tissue Inhibitors of Matrix Metalloproteinase Levels With Adverse Treatment Outcomes Among Patients With Pulmonary Tuberculosis.
Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis.
Interleukin-17 regulates matrix metalloproteinase activity in human pulmonary tuberculosis.
MMP-1(-1607G) polymorphism as a risk factor for fibrosis after pulmonary tuberculosis in Taiwan.
Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis.
Tuberous Sclerosis
Expression of matrix metalloproteinases and their endogenous tissue inhibitors in skin lesions from patients with tuberous sclerosis.
Ureteral Obstruction
Changes in matrix metalloproteinases during the evolution of interstitial renal fibrosis in a rat experimental model.
Selective inhibition of class IIa histone deacetylases alleviates renal fibrosis.
TLR4 promotes fibrosis but attenuates tubular damage in progressive renal injury.
Urinary Bladder Neck Obstruction
Effects of doxycycline on voiding behaviour of rats with bladder outlet obstruction.
Urinary Bladder Neoplasms
Alteration in urinary matrix metalloproteinase-9 to tissue inhibitor of metalloproteinase-1 ratio predicts recurrence in nonmuscle-invasive bladder cancer.
Antitumor effect of ascorbic acid, lysine, proline, arginine, and green tea extract on bladder cancer cell line T-24.
Antitumor effects of curcumin in human bladder cancer in vitro.
Association of Matrix Metalloproteinase-8 Genotypes with the Risk of Bladder Cancer.
Bacillus Calmette-Guérin enhances production and secretion of type IV collagenases in peripheral blood mononuclear cells.
Clinical significance and prognostic value of S100A4 and matrix metalloproteinase-14 in patients with organ-confined bladder cancer.
Comparison of p38MAPK (mitogene activated protein kinase), p65 NFkappaB (nuclear factor kappa b) and EMMPRIN (extracellular matrix metalloproteinase inducer) expressions with tumor grade and stage of superficial and invasive bladder tumors.
Diagnostic value of neutrophil gelatinase-associated lipocalin/matrix metalloproteinase-9 pathway in transitional cell carcinoma of the bladder.
Editorial Comment from Dr Miyata to Functional polymorphisms in the matrix metalloproteinase genes and their association with bladder cancer risk and recurrence: A mini-review.
Editorial Comment from Dr Szarvas to Functional polymorphisms in the matrix metalloproteinase genes and their association with bladder cancer risk and recurrence: A mini-review.
Evaluation of MMP-2, MMP-9, TIMP-1, TIMP-2, NGAL and MMP-9/NGAL complex in urine and sera from patients with bladder cancer.
Expression of extracellular matrix metalloproteinase inducer and fascin in urinary bladder cancer: Correlation with clinicopathological characteristics.
Extracellular matrix metalloproteinase inducer expression has an impact on survival in human bladder cancer.
Functional polymorphisms in the matrix metalloproteinase genes and their association with bladder cancer risk and recurrence: A mini-review.
Inhibition of TGF-beta receptor I by siRNA suppresses the motility and invasiveness of T24 bladder cancer cells via modulation of integrins and matrix metalloproteinase.
Inhibitory effects of resveratrol on the adhesion, migration and invasion of human bladder cancer cells.
Interleukin-20 Promotes Migration of Bladder Cancer Cells through Extracellular Signal-regulated Kinase (ERK)-mediated MMP-9 Protein Expression Leading to Nuclear Factor (NF-?B) Activation by Inducing the Up-regulation of p21WAF1 Protein Expression.
Loss of GATA3 in bladder cancer promotes cell migration and invasion.
Matrix metalloproteinase polymorphisms and bladder cancer risk.
Matrix metalloproteinase polymorphisms are associated with bladder cancer invasiveness.
MMP-8 C-799?T, Lys460Thr, and Lys87Glu variants are not related to risk of cancer.
Prognostic value of membrane type 1 and 2 matrix metalloproteinase expression and gelatinase A activity in bladder cancer.
RhoGDI? promotes Sp1/MMP-2 expression and bladder cancer invasion through perturbing miR-200c-targeted JNK2 protein translation.
Suppression of CD81 promotes bladder cancer cell invasion through increased matrix metalloproteinase expression via extracellular signal-regulated kinase phosphorylation.
The MMP-1, MMP-2, and MMP-9 gene polymorphisms and susceptibility to bladder cancer: a meta-analysis.
The role of matrix metalloproteinase MMP-9 and TIMP-2 tissue inhibitor of metalloproteinasas as serum markers of bladder cancer.
Urinary matrix metalloproteinase-7 level is associated with the presence of metastasis in bladder cancer.
Urine: beyond cytology for detection of malignancy.
Urinary Incontinence
Effect of suburethral prolene mesh for suburethral function and histology in a stress urinary incontinence mouse model.
Elastin metabolism in pelvic tissues: is it modulated by reproductive hormones?
Signs of herniosis in women with vaginal prolapse and/or stress incontinence.
The role of neutrophil elastase in elastin metabolism of pelvic tissues from women with stress urinary incontinence.
[MMP-1 and MMP-3 gene encoding polymorphism and the risk of the development of pelvic organ prolapse and stress urinary incontinence].
Urinary Tract Infections
Urinary NGAL Measured after the First Year Post Kidney Transplantation Predicts Changes in Glomerular Filtration over One-Year Follow-Up.
Uterine Cervical Neoplasms
Association between expression of MMP-7 and MMP-9 and pelvic lymph node and para-aortic lymph node metastasis in early cervical cancer.
Ataxin-1 regulates epithelial-mesenchymal transition of cervical cancer cells.
Baicalin Inhibits Human Cervical Cancer Cells by Suppressing Protein Kinase C/Signal Transducer and Activator of Transcription (PKC/STAT3) Signaling Pathway.
Characterization of extracellular matrix-degrading proteinase and its inhibitor in gynecologic cancer tissues with clinically different metastatic form.
Downregulation of Extracellular Matrix Metalloproteinase Inducer by scFv-M6-1B9 Intrabody Suppresses Cervical Cancer Invasion Through Inhibition of Urokinase-Type Plasminogen Activator.
Extracellular matrix metalloproteinase inducer (CD147/BSG/EMMPRIN)-induced radioresistance in cervical cancer by regulating the percentage of the cells in the G2/m phase of the cell cycle and the repair of DNA Double-strand Breaks (DSBs).
Extracellular matrix metalloproteinase inducer (EMMPRIN) remodels the extracellular matrix through enhancing matrix metalloproteinases (MMPs) and inhibiting tissue inhibitors of MMPs expression in HPV-positive cervical cancer cells.
Histone Deacetylase (HDAC) 10 Suppresses Cervical Cancer Metastasis through Inhibition of Matrix Metalloproteinase (MMP) 2 and 9 Expression.
Inhibition of BAP31 expression inhibits cervical cancer progression by suppressing metastasis and inducing intrinsic and extrinsic apoptosis.
Inhibition of lncRNA DCST1-AS1 suppresses proliferation, migration and invasion of cervical cancer cells by increasing miR-874-3p expression.
Metastatic Inhibitory and Radical Scavenging Efficacies of Saponins Extracted from the Brittle Star (Ophiocoma erinaceus).
No Association of Matrix Metalloproteinase [MMP]-2 (-735C > T) and Tissue Inhibitor of Metalloproteinase [TIMP]-2 (-418G > C) Gene Polymorphisms with Cervical Cancer Susceptibility.
Phloretin suppresses metastasis by targeting protease and inhibits cancer stemness and angiogenesis in human cervical cancer cells.
Promoter polymorphism in the matrix metalloproteinase-1 and risk of cervical cancer in Korean women.
RHCG suppresses cervical cancer progression through inhibiting migration and inducing apoptosis regulated by TGF-?1.
RNA interference targeting extracellular matrix metalloproteinase inducer (CD147) inhibits growth and increases chemosensitivity in human cervical cancer cells.
Silencing of long non-coding RNA NCK1-AS1 inhibits cell proliferation and migration via inhibition of microRNA-134 in cervical cancer.
The emerging role of KCl cotransport in tumor biology.
[The Role and Mechanism of CXCR4 and Its Ligand SDF-1 in the Development of Cervical Cancer Metastasis.]
Uterine Hemorrhage
Expression of matrix metalloproteinase enzymes in endometrium of women with abnormal uterine bleeding.
Uveitis
Changes in Matrix Metalloproteinase Network in a Spontaneous Autoimmune Uveitis Model.
Elevated Expression and Activation of Matrix Metalloproteinase 8 in Tear Fluid in Atopic Blepharoconjunctivitis.
Vaginosis, Bacterial
Effect of clindamycin treatment on vaginal inflammatory markers in pregnant women with bacterial vaginosis and a positive fetal fibronectin test.
Factors affecting matrix metalloproteinase-8 levels in the vaginal and cervical fluids in the first and second trimester of pregnancy.
Vaginal matrix metalloproteinase levels in pregnant women with bacterial vaginosis.
Varicocele
Impact of micronised purified flavonoid fraction on increased malondialdehyde and decreased metalloproteinase-2 and metalloproteinase-9 levels in varicocele: outcome of an experimentally induced varicocele.
Varicose Ulcer
Matrix metalloproteinase (MMP)-1 and MMP-2, but not COX-2 serve as additional predictors for chronic venous ulcer healing.
Matrix Metalloproteinase Profiles in Chronic Venous Ulcer Wound Fluid of Inflammatory and Granulating Venous Leg Ulcers.
Role of matrix metalloproteinases in non-healing venous ulcers.
Venous ulcer: what is new?
Varicose Veins
Decreased production of collagen Type III in cultured smooth muscle cells from varicose vein patients is due to a degradation by MMPs: possible implication of MMP-3.
Effect of a Peptide Construct on Differentiated Macrophage MMP-2 and MMP-9 Levels of Varicose Patients.
Inhibitory Effect of TIMP Influences the Morphology of Varicose Veins.
Matrix metalloproteinase 2-induced venous dilation via hyperpolarization and activation of K+ channels: relevance to varicose vein formation.
Polymorphism of matrix metalloproteinase genes (MMP1 and MMP3) in patients with varicose veins.
Polymorphism of Matrix Metalloproteinases Genes MMP1, MMP2, MMP3, and MMP7 and the Risk of Varicose Veins of Lower Extremities.
[Lower extremity varicose veins in childhood and at a young age: Mechanism of development and specific features].
Vascular Calcification
Elastin-derived peptides and TGF-beta1 induce osteogenic responses in smooth muscle cells.
Recombinant Human Thrombomodulin Suppresses Experimental Abdominal Aortic Aneurysms Induced by Calcium Chloride in Mice.
Vascular Diseases
Can proteomics yield insight into aging aorta?
Causal associations of serum matrix metalloproteinase-8 level with ischaemic stroke and ischaemic stroke subtypes: a Mendelian randomization study.
Chemical biology for understanding matrix metalloproteinase function.
Elastase and matrix metalloproteinase activities are associated with pulmonary vascular disease in the nitrofen rat model of congenital diaphragmatic hernia.
Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease.
Genetic studies on the role of proteinases and growth factors in atherosclerosis and aneurysm formation.
Genetic variation in the matrix metalloproteinase genes and diabetic nephropathy in type 1 diabetes.
Increased tissue microarray matrix metalloproteinase expression favors proteolysis in thoracic aortic aneurysms and dissections.
Lack of an association between matrix metalloproteinase polymorphisms and coronary heart disease in a Han Chinese population.
Matrix metalloproteinase inhibition therapy for vascular diseases.
Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease.
Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases.
Matrix metalloproteinases and atherosclerotic plaque instability.
Role of matrix metalloproteinases in early hypertensive vascular remodeling.
Structural and functional characterization of tissue factor pathway inhibitor following degradation by matrix metalloproteinase-8.
The role of matrix metalloproteinases in vascular disease.
Vascular System Injuries
Accelerated neointima formation after vascular injury in mice with stromelysin-3 (MMP-11) gene inactivation.
Carvedilol, a pharmacological antioxidant, inhibits neointimal matrix metalloproteinase-2 and -9 in experimental atherosclerosis.
Cisatracurium attenuates LPS-induced modulation of MMP3 and junctional protein expression in human microvascular endothelial cells.
Effect of hormone replacement therapy in matrix metalloproteinase expression and intimal hyperplasia development after vascular injury.
Function of the plasminogen/plasmin and matrix metalloproteinase systems after vascular injury in mice with targeted inactivation of fibrinolytic system genes.
Gene transfer of the urokinase-type plasminogen activator receptor-targeted matrix metalloproteinase inhibitor TIMP-1.ATF suppresses neointima formation more efficiently than tissue inhibitor of metalloproteinase-1.
Metalloproteinase inhibition by batimastat does not reduce neointimal thickening in stented atherosclerotic porcine femoral arteries.
NPY promotes macrophage migration by upregulating matrix metalloproteinase-8 expression.
Regulation of MMP-9 expression by the A2b adenosine receptor and its dependency on TNF-? signaling.
Role of the fibrinolytic and matrix metalloproteinase systems in arterial neointima formation after vascular injury.
Temporal and topographic matrix metalloproteinase expression after vascular injury in mice.
Vascular Imaging of Matrix Metalloproteinase Activity as an Informative Preclinical Biomarker of Drug-induced Vascular Injury.
Vasculitis
Association between matrix metalloproteinase 9 promoter polymorphisms and Behçet's disease.
Molecular imaging reveals time course of matrix metalloproteinase activity in acute cutaneous vasculitis in vivo.
Venous Thrombosis
Plasmin and matrix metalloproteinase system in deep venous thrombosis resolution.
Plasmin inhibition increases MMP-9 activity and decreases vein wall stiffness during venous thrombosis resolution.
Ventilator-Induced Lung Injury
Absence or Inhibition of Matrix Metalloproteinase-8 Decreases Ventilator-induced Lung Injury.
Ventilator-induced lung injury upregulates and activates gelatinases and EMMPRIN: attenuation by the synthetic matrix metalloproteinase inhibitor, Prinomastat (AG3340).
Ventricular Dysfunction
Investigation of association of genetic variant rs3918242 of matrix metalloproteinase-9 with hypertension, myocardial infarction and progression of ventricular dysfunction in Irish Caucasian patients with diabetes: a report from the STOP-HF follow-up programme.
Ventricular Dysfunction, Left
Fibrosis of the left atria during progression of heart failure is associated with increased matrix metalloproteinases in the rat.
Immunomodulation by interleukin-4 suppresses matrix metalloproteinases and improves cardiac function in murine myocarditis.
Selective matrix metalloproteinase inhibition attenuates progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure.
Ventricular Dysfunction, Right
Matrix metalloproteinase inhibition attenuates right ventricular dysfunction and improves responses to dobutamine during acute pulmonary thromboembolism.
Virus Diseases
Ablation of matrix metalloproteinase-9 increases severity of viral myocarditis in mice.
Association between matrix metalloproteinase (MMP)-2, MMP-9 and total antioxidant status of patients with asymptomatic hepatitis C virus infection.
Matrix metalloproteinase expression correlates with virulence following neurotropic mouse hepatitis virus infection.
Mononuclear phagocyte differentiation, activation, and viral infection regulate matrix metalloproteinase expression: implications for human immunodeficiency virus type 1-associated dementia.
Serum matrix metalloproteinase levels correlate with brain injury in human immunodeficiency virus infection.
Targeting the Host Response: Can We Manipulate Extracellular Matrix Metalloproteinase Activity to Improve Influenza Virus Infection Outcomes?
The role of Smad1/5 in mantle immunity of the pearl oyster Pinctada fucata martensii.
Vitamin A Deficiency
Vitamin A deficiency disturbs collagen IV and laminin composition and decreases matrix metalloproteinase concentrations in rat lung. Partial reversibility by retinoic acid.
Vitamin D Deficiency
Circulating MMP9, vitamin D and variation in the TIMP-1 response with VDR genotype: mechanisms for inflammatory damage in chronic disorders?
Vitamin D Inhibits Activities of Metalloproteinase-9/-13 in Articular Cartilage In Vivo and In Vitro.
Vitiligo
Matrix metalloproteinase in acral and non-acral vitiligo.
Vitreoretinopathy, Proliferative
Comparison of interleukin-6 and matrix metalloproteinase expression in the subretinal fluid and the vitreous during proliferative vitreoretinopathy: Correlations with extent, duration of RRD and PVR grade.
Correlation of matrix metalloproteinase levels with the grade of proliferative vitreoretinopathy in the subretinal fluid and vitreous during rhegmatogenous retinal detachment.
Interleukin-6 and matrix metalloproteinase expression in the subretinal fluid during proliferative vitreoretinopathy: correlation with extent, duration of RRD and PVR grade.
Interleukin-6 and the matrix metalloproteinase response in the vitreous during proliferative vitreoretinopathy.
The effect of prinomastat (AG3340), a potent inhibitor of matrix metalloproteinases, on a subacute model of proliferative vitreoretinopathy.
[Progress in studies on effects of extracellular matrix in occurrence of proliferative vitreoretinopathy]
Waldenstrom Macroglobulinemia
Matrix Metalloproteinase-8 Is Overexpressed in Waldenström's Macroglobulinemia Cells, and Specific Inhibition of this Metalloproteinase Blocks Release of Soluble CD27.
Whooping Cough
Effect of cholera toxin and pertussis toxin on prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinase production by human monocytes.
Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1.
Lysophosphatidic acid transactivates both c-Met and epidermal growth factor receptor, and induces cyclooxygenase-2 expression in human colon cancer LoVo cells.
Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9.
Thymoquinone-induced Neu4 sialidase activates NF?B in macrophage cells and pro-inflammatory cytokines in vivo.
Wilms Tumor
A carcinogenic trigger to study the function of tumor suppressor genes in Schmidtea mediterranea.
Wound Infection
Nanocrystalline silver dressings in wound management: a review.
Xanthomatosis
Verruciform xanthoma of the oral cavity: clinicopathological study relating to pathogenesis. Report of three cases.
Xerophthalmia
The role and function of matrix metalloproteinase-8 in rhegmatogenous retinal detachment.