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Information on EC 3.4.24.19 - procollagen C-endopeptidase and Organism(s) Homo sapiens
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3.4.24.19 procollagen C-endopeptidaseSpecify your search results
Word Map
- 3.4.24.19
- procollagens
- metalloproteinases
- proteinases
- chordin
-
fibril
-
gastrulation
- c-propeptide
- astacins
- metalloprotease
-
fibrillar
- pcpe-1
-
decapentaplegic
- desulfitobacterium
- pentachlorophenol
- urchin
- sialoprotein
- hafniense
- meprin
-
gastrula
-
astacin-like
-
n-proteinase
-
pcolce
- imperfecta
-
dorsoventral
- bmp4
- sialophosphoprotein
-
dechlorination
- prodomains
- noggin
-
metzincins
-
osteoinductive
- medicine
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
cleavage of the C-terminal propeptide at Ala-/-Asp in type I and II procollagens and at Arg-/-Asp in type III
Synonyms
bmp-1, tolloid, procollagen c-proteinase, pcp-2, pcp-1, bone morphogenetic protein 1, bone morphogenetic protein-1, mammalian tolloid, procollagen c-endopeptidase, procollagen peptidase, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
BMP-1
bone morphogenetic protein 1
bone morphogenetic protein-1
Carboxy-terminal endopeptidase
-
-
-
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Carboxyl procollagen peptidase
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-
-
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Carboxyprocollagen peptidase
-
-
-
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Mammalian tolloid protein
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-
-
-
MtlD
PCP
Peptidase, procollagen C-terminal
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-
-
-
Procollagen C-proteinase
Procollagen C-terminal proteinase
-
-
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Procollagen carboxy-terminal proteinase
-
-
-
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Procollagen carboxypeptidase
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-
-
-
Procollagen peptidase
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-
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Proteinase, procollagen C-terminal
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Type I procollagen C-proteinase
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-
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-
MtlD
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-
-
-
PCP
-
-
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Procollagen C-proteinase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of peptide bond
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-
-
-
CAS REGISTRY NUMBER
COMMENTARY
68651-95-6
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-(4'-(dimethylaminophenylazo)-benzoyl)-Arg-Tyr-Tyr-Arg-Ala-Asp-Asp-Ala-Asn-Val-Glu-(EDANS)-NH2 + H2O
?
-
-
-
-
?
bovine lysyl oxidase-like precursor protein + H2O
?
-
cleaved at a Gly-Asp and Ser-Asp bond
-
-
?
Collagen type I + H2O
?
-
affinity of C-terminal CUB/EGF PCP constructs for collagen type I is weaker than that for procollagen type I
-
-
?
lamin 5 + H2O
?
-
gamma2 chain cleaved at a Gly-Asp bond, also cleavage of alpha3 chain
-
-
?
Procollagen type I + H2O
Type I pNcollagen + C-propeptides
-
-
-
-
?
thrombospondin-1 + H2O
?
-
thrombospondin-1 is differently cleaved by both BMP1 and its catalytic domain
-
-
?
truncated procollagen VII + H2O
?
-
the protease domain alone cleaves truncated procollagen VII within the short telopeptide region into fragments of similar size as the full-length enzyme does. The C-terminal domains of BMP1 are important for substrate recognition and for controlling and restricting its proteolytic activity via exosite binding
-
-
?
procollagen C-propeptide + H2O
?
cleaves the C-propeptides of type I procollagen during the synthesis of extracellular matrix collagen fibrils
-
?
procollagen C-propeptide + H2O
?
cleaves the C-propeptides of type I procollagen during the synthesis of extracellular matrix collagen fibrils
-
?
Procollagen type I + H2O
?
-
constructs containing EGF domains bind more strongly than those consisting of CUB domains only
-
-
?
procollagen type I + H2O
collagen type I + collagen type I propeptide
-
-
-
?
procollagen type I + H2O
collagen type I + collagen type I propeptide
usage of chicken embryo fibroblasts tendon procollagen type I labeled biosynthetically with H3-tryptophan
-
-
?
additional information
?
-
-
the protease domain cleaves other matrix proteins such as fibronectin, collagen I and collagen IV, which are left intact by the full-length enzyme
-
-
?
additional information
?
-
-
the enzyme cleaves both pro-collagen and non-collagen substrates involved in forming functional collagen fibrils. Enzyme cleavage sequences in enzyme substrates types I, II, and III collagen indicate a substrate preference for P3 Met or Tyr, for P2 Arg or Tyr, for P1 Ala or Gly, for P1' Asp, for P2' Asp, Glu, or Gln; and for P3' Ala or Pro
-
-
?
additional information
?
-
-
substrate specificity, overview, peptides PYYGD and PYYGAEPM are no sbstrates for the enzyme
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
procollagen type I + H2O
collagen type I + collagen type I propeptide
-
-
-
?
additional information
?
-
-
the enzyme cleaves both pro-collagen and non-collagen substrates involved in forming functional collagen fibrils. Enzyme cleavage sequences in enzyme substrates types I, II, and III collagen indicate a substrate preference for P3 Met or Tyr, for P2 Arg or Tyr, for P1 Ala or Gly, for P1' Asp, for P2' Asp, Glu, or Gln; and for P3' Ala or Pro
-
-
?
procollagen C-propeptide + H2O
?
cleaves the C-propeptides of type I procollagen during the synthesis of extracellular matrix collagen fibrils
-
?
procollagen C-propeptide + H2O
?
cleaves the C-propeptides of type I procollagen during the synthesis of extracellular matrix collagen fibrils
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Zn2+
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(3R)-3-(3-[[acetyl(methyl)amino]methyl]-1,2,4-oxadiazol-5-yl)-6-cyclohexyl-N-hydroxyhexanamide
-
-
(3R)-3-[3-(6-aminopyridin-3-yl)-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
-
-
(3R)-3-[3-(aminomethyl)-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
-
-
(3R)-3-[3-([[(aminooxy)sulfinyl]amino]methyl)-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
-
-
(3R)-3-[3-[(acetylamino)methyl]-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
-
-
(3R)-3-[3-[(carbamoylamino)methyl]-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
-
-
(3R)-3-[3-[(cyclobutylamino)methyl]-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
-
-
(3R)-3-[3-[(tert-butylamino)methyl]-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
-
-
(3R)-6-cyclohexyl-3-(3-[[(cyclopropylsulfonyl)amino]methyl]-1,2,4-oxadiazol-5-yl)-N-hydroxyhexanamide
-
-
(3R)-6-cyclohexyl-3-[3-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
-
-
(3R)-6-cyclohexyl-3-[3-[(cyclopropylamino)methyl]-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
-
-
(3R)-6-cyclohexyl-3-[3-[(dimethylamino)methyl]-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
-
-
(3R)-6-cyclohexyl-3-[3-[(ethylamino)methyl]-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
-
-
(3R)-6-cyclohexyl-3-[3-[6-(dimethylamino)pyridin-3-yl]-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-(3-pyrazin-2-yl-1,2,4-oxadiazol-5-yl)hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-(3-pyridin-4-yl-1,2,4-oxadiazol-5-yl)hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-(3-pyrimidin-2-yl-1,2,4-oxadiazol-5-yl)hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-(3-pyrimidin-5-yl-1,2,4-oxadiazol-5-yl)hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-(3-[2-[(methylsulfinyl)amino]ethyl]-1,2,4-oxadiazol-5-yl)hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-(3-[[(1-methylethyl)amino]methyl]-1,2,4-oxadiazol-5-yl)hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-(3-[[(2-hydroxy-1,1-dimethylethyl)amino]methyl]-1,2,4-oxadiazol-5-yl)hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(1-methyl-1H-imidazol-2-yl)-1,2,4-oxadiazol-5-yl]hexanamide
-
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(3R)-6-cyclohexyl-N-hydroxy-3-[3-(1H-pyrazol-4-yl)-1,2,4-oxadiazol-5-yl]hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(4H-pyrazol-3-yl)-1,2,4-oxadiazol-5-yl]hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(6-methylpyridazin-3-yl)-1,2,4-oxadiazol-5-yl]hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(morpholin-4-ylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(pyridin-2-ylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(pyridin-3-ylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(pyridin-4-ylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(pyrrolidin-1-ylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-[3-[(4-hydroxypiperidin-1-yl)methyl]-1,2,4-oxadiazol-5-yl]hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-[3-[(methylamino)methyl]-1,2,4-oxadiazol-5-yl]hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-[3-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1,2,4-oxadiazol-5-yl]hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-[3-[6-(methylamino)pyridin-3-yl]-1,2,4-oxadiazol-5-yl]hexanamide
-
-
1H-pyrazol-4-yl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
-
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2-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)-N,N-dimethylpyridine-4-carboxamide
-
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2-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)-N-methylpyridine-4-carboxamide
-
-
2-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)pyridine-4-carboxamide
-
-
2-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)pyridine-4-carboxylic acid
-
-
2-(N-((3s,5s,7s)-adamantan-1-yl)-4-methoxyphenylsulfonamido)-N-hydroxyacetamide
-
9-21% inhibition at 0.010 mM
2-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-5-methyl-1,3-oxazole-4-carboxamide
-
-
2-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-N,N-dimethyl-5-methyl-1,3-oxazole-4-carboxamide
-
-
2-[[3-(hydroxyamino)-3-oxopropyl][2-(4-methoxyphenyl)ethyl]sulfamoyl]benzoic acid
-
32% inhibition at 0.010 mM
3-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)benzoic acid
-
-
4-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)benzoic acid
-
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4-[[3-(hydroxyamino)-3-oxopropyl][2-(4-methoxyphenyl)ethyl]sulfamoyl]-N-phenylbenzamide
-
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5-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)pyridine-2-carboxylic acid
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5-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)pyridine-3-carboxylic acid
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5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-N-(phenylsulfonyl)-1,2,4-oxadiazole-3-carboxamide
-
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5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-N-[(3,4-dimethoxyphenyl)sulfonyl]-1,2,4-oxadiazole-3-carboxamide
-
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5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-N-[(4-fluorophenyl)sulfonyl]-1,2,4-oxadiazole-3-carboxamide
-
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5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-N-[(4-methoxyphenyl)sulfonyl]-1,2,4-oxadiazole-3-carboxamide
-
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5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-N-[(4-methylphenyl)sulfonyl]-1,2,4-oxadiazole-3-carboxamide
-
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5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-1,2,4-oxadiazole-3-carboxamide
-
i.e. UK-383,367. Good selectivity over matrix metalloproteinases involved in wound healing, effective in a cell-based model of collagen deposition and in penetrating human skin in vitro
5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-N,N-dimethyl-1,2,4-oxadiazole-3-carboxamide
-
good selectivity over matrix metalloproteinases involved in wound healing
5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-N-isopropyl-1,2,4-oxadiazole-3-carboxamide
-
-
acidic dipeptide hydroxamate derivates
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mimic the location of aspartic acid residues in the P1' and P2' positions of the PCP cleavage site in procollagen
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Asp-Pro-Ile-Val-Cys-Pro-Pro-Leu-Asn-Cys-Ser-Gln-Pro-Val-His-Leu-Pro-Asp-Gln
peptide derived from amino acids 727-745 of chordin
butyl [[2-(hydroxyamino)-2-oxoethyl][(4-methoxyphenyl)sulfonyl]amino]acetate
-
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cyclopropyl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
-
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ethyl 3-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)benzoate
-
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ethyl 4-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)benzoate
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-
ethyl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
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-
methyl 4-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)piperidine-1-sulfinate
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methyl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
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methyl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]methylamidosulfite
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methyl [4-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)phenyl]amidosulfite
-
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methyl [5-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)pyridin-2-yl]amidosulfite
-
-
N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-[4-(trifluoromethyl)benzyl]glycinamide
-
-
N-hydroxy-N2-[2-(4-methoxyphenyl)ethyl]-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
-
-
N-hydroxy-N3-(4-methoxyphenyl)-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
-
-
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-(2-phenylethyl)-beta-alaninamide
-
-
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(4-nitrophenyl)ethyl]-beta-alaninamide
-
-
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(4-sulfamoylphenyl)ethyl]-beta-alaninamide
-
-
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(morpholin-4-yl)ethyl]-beta-alaninamide
-
-
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(pyridin-2-yl)ethyl]-beta-alaninamide
-
-
N-hydroxy-N3-[(4-[[(4-methoxyphenyl)carbamoyl]amino]phenyl)sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
-
N-hydroxy-N3-[2-(2-methoxyphenyl)ethyl]-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
-
45% inhibition at 0.010 mM
N-hydroxy-N3-[2-(3-methoxyphenyl)ethyl]-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
-
-
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-([4-[(methylcarbamoyl)amino]phenyl]sulfonyl)-beta-alaninamide
-
-
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-([4-[(phenoxycarbamoyl)amino]phenyl]sulfonyl)-beta-alaninamide
-
-
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-([4-[(phenylcarbamoyl)amino]phenyl]sulfonyl)-beta-alaninamide
-
-
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
-
-
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[(4-[[(2-phenylethyl)carbamoyl]amino]phenyl)sulfonyl]-beta-alaninamide
-
-
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[[2-(methylsulfonyl)phenyl]sulfonyl]-beta-alaninamide
-
-
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[[4-(methylsulfonyl)phenyl]sulfonyl]-beta-alaninamide
-
-
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[[4-([[4-(trifluoromethyl)phenyl]carbamoyl]amino)phenyl]sulfonyl]-beta-alaninamide
-
-
N-hydroxy-N3-[[2-(N'-hydroxycarbamimidoyl)phenyl]sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
-
N-hydroxy-N3-[[3-(N'-hydroxycarbamimidoyl)phenyl]sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
-
N-hydroxy-N3-[[4-(N'-hydroxycarbamimidoyl)phenyl]sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
-
N-[(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)carbonyl]glycine
-
-
N-[2-(4-methoxyphenyl)ethyl]-4-(methylsulfonyl)-N-(2-sulfanylethyl)benzenesulfonamide
-
-
N-[2-(4-methoxyphenyl)ethyl]-4-(methylsulfonyl)-N-(3-sulfanylpropyl)benzenesulfonamide
-
-
N-[2-[carbamoyl(hydroxy)amino]ethyl]-N-[2-(4-methoxyphenyl)ethyl]-4-(methylsulfonyl)benzenesulfonamide
-
-
N2-[2-(4-methoxyphenyl)ethyl]-N2-[[4-(methylsulfonyl)phenyl]sulfonyl]-N-sulfanylglycinamide
-
-
N2-[2-(carboxymethyl)-4-(hydroxyamino)-4-oxobutanoyl]-N-methyl-L-alpha-glutamine
-
-
N3-(cyclohexylmethyl)-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
-
-
N3-([4-[(biphenyl-4-ylcarbamoyl)amino]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
-
N3-([4-[(diphenoxycarbamoyl)amino]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
-
N3-([4-[(diphenylcarbamoyl)amino]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
-
N3-([4-[amino(phenylsulfonyl)methyl]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
-
N3-[(4-tert-butylphenyl)sulfonyl]-N-hydroxy-N3-(2-phenylethyl)-beta-alaninamide
-
-
N3-[(4-[[(4-chlorophenyl)carbamoyl]amino]phenyl)sulfonyl]-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
-
N3-[2-(3,4-dimethoxyphenyl)ethyl]-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
-
-
N3-[2-(4-methoxyphenyl)ethyl]-N3-[[4-(methylsulfonyl)phenyl]sulfonyl]-N-sulfanyl-beta-alaninamide
-
-
phenyl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
-
-
pyridin-2-yl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
-
-
pyridin-3-yl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
-
-
Cys-Asp-Pro-Ile-Val-Cys
minimal inhibitory peptide, derived from amino acids 726-731 of chordin. Peptide is not cleaved but instead undergoes cyclization by disulfide formation
Cys-Asp-Pro-Ile-Val-Cys
-
inhibits procollagen C-endopeptidase activity in vitro
Gln-Lys-Arg-Thr-Val-Ile-Cys-Asp-Pro-Ile-Val-Cys-Pro-Pro-Leu-Asn
peptide derived from amino acids 720-735 of chordin. Peptide is not cleaved but instead undergoes cyclization by disulfide formation
Gln-Lys-Arg-Thr-Val-Ile-Cys-Asp-Pro-Ile-Val-Cys-Pro-Pro-Leu-Asn
-
inhibits procollagen C-endopeptidase activity in vitro
additional information
-
procollagen C-proteinase enhancer-1 is not an inhibitor of BMP-1
-
additional information
-
the cyclic form AS1.11c (Gln-Lys-Arg-Thr-Val-Ile-Cys-Asp-Pro-Ile-Val-Cys-Pro-Pro-Leu-Asn) does not inhibit procollagen C-endopeptidase activity on procollagen type I
-
additional information
-
design from substrate leads and synthesis of procollagen C-proteinase inhibitors, overview. The compounds are optimized for potency and selectivity, with N-substituted aryl sulfonamide hydroxamates having the best combination of these properties
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
heparin
-
stimulation of BMP-1 activity by procollagen C-proteinase enhancer-1 is further increased by the presence of 0.05 mg/ml heparin
heparin sulfate
-
in the presence of both procollagen C-proteinase enhancer-1 and heparin or heparan sulfate, the activity of BMP-1 is further stimulated
PCPE-1
-
enhances degredation of procollagen type I 5 fold, enhances C-terminal processing of procollagen type III when this substrate is in its native, disulfide-bonded conformation, has no effect on the in vitro BMP-1 processing of procollagen VII, procollagen V N-propeptide, laminin 5 gamma2 chain, osteoglycin, prolysyl oxidase or chordin
-
procollagen C-proteinase enhancer 2
-
specifically activates bone morphogenetic protein-1, the CUB domains CUB1 and CUB2 of procollagen C-proteinase enhancer 1 are capable of enhancing BMP-1 activity and binding to a mini-procollagen substrate with nanomolar affinity
-
procollagen C-proteinase enhancer-2
-
procollagen C-proteinase enhancer-2 (PCPE2) interacts with BMP-1 and pro-apoAI to form a ternary pro-apoAI/BMP-1/PCPE2 complex, PCPE2 enhances the BMP-1 cleavage and maturation of pro-apoAI
-
TGFbeta
-
increases the expression of BMP-1 and Tld in human dermal fibroblasts
-
procollagen C-proteinase enhancer 1
-
enhances full length BMP1 and not truncated versions missing the most COOH-terminal EGF and CUB domains
-
procollagen C-proteinase enhancer 1
-
procollagen C-proteinase enhancer 1 specifically stimulates the PCP activity of bone morphogenic protein 1
-
procollagen C-proteinase enhancer 1
-
specifically activates bone morphogenetic protein-1, the CUB domains CUB1 and CUB2 of procollagen C-proteinase enhancer 1 are capable of enhancing BMP-1 activity and binding to a mini-procollagen substrate with nanomolar affinity
-
procollagen C-proteinase enhancer 1
PCPE-1, CUB (Complement C1r/C1s, Uegf, BMP-1) and netrin-like (NTR) domains fragments of PCPE-1 are generated by limited proteolysis with trypsin and isolated by heparin affinity chromatography
-
procollagen C-proteinase enhancer-1
-
PCPE-1 is an extracellular glycoprotein that increases activity of BMP-1. PCPE-1 enhances proteolysis by binding solely to the procollagen C-propeptides
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
additional information
kinetic constants using Lineweaver-Burk plots and Michaelis-Menten equation
-
0.00009
Procollagen type I
pH and temperature not specified in the publication, recombinant enzyme, in presence of PCPE-1 CUB1/CUB2 domains
0.0001
Procollagen type I
pH and temperature not specified in the publication, recombinant enzyme, in presence of PCPE-1
0.00019
Procollagen type I
pH and temperature not specified in the publication, recombinant enzyme, in presence of PCPE-1 NTR domain
0.00039
Procollagen type I
pH and temperature not specified in the publication, recombinant enzyme
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.013
Procollagen type I
pH and temperature not specified in the publication, recombinant enzyme, in presence of PCPE-1 NTR domain
0.016
Procollagen type I
pH and temperature not specified in the publication, recombinant enzyme
0.053
Procollagen type I
pH and temperature not specified in the publication, recombinant enzyme, in presence of PCPE-1 CUB1/CUB2 domains
0.059
Procollagen type I
pH and temperature not specified in the publication, recombinant enzyme, in presence of PCPE-1
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
41.03
Procollagen type I
pH and temperature not specified in the publication, recombinant enzyme
68.42
Procollagen type I
pH and temperature not specified in the publication, recombinant enzyme, in presence of PCPE-1 NTR domain
588.9
Procollagen type I
pH and temperature not specified in the publication, recombinant enzyme, in presence of PCPE-1 CUB1/CUB2 domains
590
Procollagen type I
pH and temperature not specified in the publication, recombinant enzyme, in presence of PCPE-1
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.000003
(3R)-3-(3-[[acetyl(methyl)amino]methyl]-1,2,4-oxadiazol-5-yl)-6-cyclohexyl-N-hydroxyhexanamide
Homo sapiens
-
-
0.000018
(3R)-3-[3-(6-aminopyridin-3-yl)-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
Homo sapiens
-
-
0.000122
(3R)-3-[3-(aminomethyl)-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
Homo sapiens
-
-
0.000098
(3R)-3-[3-([[(aminooxy)sulfinyl]amino]methyl)-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
Homo sapiens
-
-
0.000019
(3R)-3-[3-[(acetylamino)methyl]-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
Homo sapiens
-
-
0.000324
(3R)-3-[3-[(carbamoylamino)methyl]-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
Homo sapiens
-
-
0.000006
(3R)-3-[3-[(cyclobutylamino)methyl]-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
Homo sapiens
-
-
0.00001
(3R)-3-[3-[(tert-butylamino)methyl]-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
Homo sapiens
-
-
0.000015
(3R)-6-cyclohexyl-3-(3-[[(cyclopropylsulfonyl)amino]methyl]-1,2,4-oxadiazol-5-yl)-N-hydroxyhexanamide
Homo sapiens
-
-
0.00001
(3R)-6-cyclohexyl-3-[3-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
Homo sapiens
-
-
0.000046
(3R)-6-cyclohexyl-3-[3-(2-furyl)-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
Homo sapiens
-
-
0.000006
(3R)-6-cyclohexyl-3-[3-[(cyclopropylamino)methyl]-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
Homo sapiens
-
-
0.000031
(3R)-6-cyclohexyl-3-[3-[(dimethylamino)methyl]-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
Homo sapiens
-
-
0.000021
(3R)-6-cyclohexyl-3-[3-[(ethylamino)methyl]-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
Homo sapiens
-
-
0.000028
(3R)-6-cyclohexyl-3-[3-[6-(dimethylamino)pyridin-3-yl]-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
Homo sapiens
-
-
0.000116
(3R)-6-cyclohexyl-N-hydroxy-3-(3-phenyl-1,2,4-oxadiazol-5-yl)hexanamide
Homo sapiens
-
-
0.000014
(3R)-6-cyclohexyl-N-hydroxy-3-(3-pyrazin-2-yl-1,2,4-oxadiazol-5-yl)hexanamide
Homo sapiens
-
-
0.000025
(3R)-6-cyclohexyl-N-hydroxy-3-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)hexanamide
Homo sapiens
-
-
0.000023
(3R)-6-cyclohexyl-N-hydroxy-3-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)hexanamide
Homo sapiens
-
-
0.000002
(3R)-6-cyclohexyl-N-hydroxy-3-(3-pyridin-4-yl-1,2,4-oxadiazol-5-yl)hexanamide
Homo sapiens
-
-
0.000023
(3R)-6-cyclohexyl-N-hydroxy-3-(3-pyrimidin-2-yl-1,2,4-oxadiazol-5-yl)hexanamide
Homo sapiens
-
-
0.000014
(3R)-6-cyclohexyl-N-hydroxy-3-(3-pyrimidin-5-yl-1,2,4-oxadiazol-5-yl)hexanamide
Homo sapiens
-
-
0.00002
(3R)-6-cyclohexyl-N-hydroxy-3-(3-[2-[(methylsulfinyl)amino]ethyl]-1,2,4-oxadiazol-5-yl)hexanamide
Homo sapiens
-
-
0.000029
(3R)-6-cyclohexyl-N-hydroxy-3-(3-[[(1-methylethyl)amino]methyl]-1,2,4-oxadiazol-5-yl)hexanamide
Homo sapiens
-
-
0.000008
(3R)-6-cyclohexyl-N-hydroxy-3-(3-[[(2-hydroxy-1,1-dimethylethyl)amino]methyl]-1,2,4-oxadiazol-5-yl)hexanamide
Homo sapiens
-
-
0.000092
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(1-methyl-1H-imidazol-2-yl)-1,2,4-oxadiazol-5-yl]hexanamide
Homo sapiens
-
-
0.000039
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(1H-pyrazol-4-yl)-1,2,4-oxadiazol-5-yl]hexanamide
Homo sapiens
-
-
0.000074
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(4H-pyrazol-3-yl)-1,2,4-oxadiazol-5-yl]hexanamide
Homo sapiens
-
-
0.00003
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(6-methylpyridazin-3-yl)-1,2,4-oxadiazol-5-yl]hexanamide
Homo sapiens
-
-
0.000005
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(morpholin-4-ylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
Homo sapiens
-
-
0.000006
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(pyridin-2-ylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
Homo sapiens
-
-
0.000006
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(pyridin-3-ylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
Homo sapiens
-
-
0.000028
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(pyridin-4-ylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
Homo sapiens
-
-
0.000024
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(pyrrolidin-1-ylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
Homo sapiens
-
-
0.000013
(3R)-6-cyclohexyl-N-hydroxy-3-[3-[(4-hydroxypiperidin-1-yl)methyl]-1,2,4-oxadiazol-5-yl]hexanamide
Homo sapiens
-
-
0.000023
(3R)-6-cyclohexyl-N-hydroxy-3-[3-[(methylamino)methyl]-1,2,4-oxadiazol-5-yl]hexanamide
Homo sapiens
-
-
0.000008
(3R)-6-cyclohexyl-N-hydroxy-3-[3-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1,2,4-oxadiazol-5-yl]hexanamide
Homo sapiens
-
-
0.000013
(3R)-6-cyclohexyl-N-hydroxy-3-[3-[6-(methylamino)pyridin-3-yl]-1,2,4-oxadiazol-5-yl]hexanamide
Homo sapiens
-
-
0.042
1-acetyl-L-prolyl-L-tyrosyl-L-tyrosyl-N-hydroxyglycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000088
1H-pyrazol-4-yl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
Homo sapiens
-
-
0.000017
2-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)-N,N-dimethylpyridine-4-carboxamide
Homo sapiens
-
-
0.00003
2-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)-N-methylpyridine-4-carboxamide
Homo sapiens
-
-
0.000017
2-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)pyridine-4-carboxamide
Homo sapiens
-
-
0.000006
2-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)pyridine-4-carboxylic acid
Homo sapiens
-
-
0.000017
2-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-5-methyl-1,3-oxazole-4-carboxamide
Homo sapiens
-
-
0.000017
2-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-N,N-dimethyl-5-methyl-1,3-oxazole-4-carboxamide
Homo sapiens
-
-
0.000006
3-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)benzoic acid
Homo sapiens
-
-
0.000032
4-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)benzoic acid
Homo sapiens
-
-
0.01
4-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-N-hydroxybutanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.001
4-[[3-(hydroxyamino)-3-oxopropyl](2-phenylethyl)sulfamoyl]benzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.00041
4-[[3-(hydroxyamino)-3-oxopropyl][2-(4-methoxyphenyl)ethyl]sulfamoyl]-N-phenylbenzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000059
5-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)pyridine-2-carboxylic acid
Homo sapiens
-
-
0.000017
5-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)pyridine-3-carboxylic acid
Homo sapiens
-
-
0.000007
5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-N-(phenylsulfonyl)-1,2,4-oxadiazole-3-carboxamide
Homo sapiens
-
-
0.0000018
5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-N-[(3,4-dimethoxyphenyl)sulfonyl]-1,2,4-oxadiazole-3-carboxamide
Homo sapiens
-
-
0.000033
5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-N-[(4-fluorophenyl)sulfonyl]-1,2,4-oxadiazole-3-carboxamide
Homo sapiens
-
-
0.000017
5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-N-[(4-methoxyphenyl)sulfonyl]-1,2,4-oxadiazole-3-carboxamide
Homo sapiens
-
-
0.000014
5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-N-[(4-methylphenyl)sulfonyl]-1,2,4-oxadiazole-3-carboxamide
Homo sapiens
-
-
0.000044
5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-1,2,4-oxadiazole-3-carboxamide
Homo sapiens
-
-
0.00001
5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-N,N-dimethyl-1,2,4-oxadiazole-3-carboxamide
Homo sapiens
-
-
0.000021
5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-N-isopropyl-1,2,4-oxadiazole-3-carboxamide
Homo sapiens
-
-
0.167
butyl [[2-(hydroxyamino)-2-oxoethyl][(4-methoxyphenyl)sulfonyl]amino]acetate
Homo sapiens
-
pH and temperature not specified in the publication
0.000021
cyclopropyl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
Homo sapiens
-
-
0.000184
ethyl 3-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)benzoate
Homo sapiens
-
-
0.000154
ethyl 4-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)benzoate
Homo sapiens
-
-
0.000026
ethyl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
Homo sapiens
-
-
0.000003
methyl 4-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)piperidine-1-sulfinate
Homo sapiens
-
-
0.000011
methyl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
Homo sapiens
-
-
0.000038
methyl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]methylamidosulfite
Homo sapiens
-
-
0.000003
methyl [4-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)phenyl]amidosulfite
Homo sapiens
-
-
0.000027
methyl [5-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)pyridin-2-yl]amidosulfite
Homo sapiens
-
-
0.0049
N-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-phenylethyl)amino]butanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.028
N-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](phenyl)amino]butanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.029
N-hydroxy-N2-(4-methoxybenzyl)-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.073
N-hydroxy-N2-(4-methoxyphenyl)-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.01
N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-L-alpha-asparagine
Homo sapiens
-
pH and temperature not specified in the publication
0.018
N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-(2-phenylethyl)glycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.069
N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-phenylglycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.067
N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-[4-(trifluoromethyl)benzyl]glycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.018
N-hydroxy-N2-[2-(4-methoxyphenyl)ethyl]-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0022
N-hydroxy-N3-(2-phenylethyl)-N3-(phenylsulfonyl)-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0017
N-hydroxy-N3-(4-methoxyphenyl)-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.166
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0009
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-(2-phenylethyl)-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.003
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-phenyl-b-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.011
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(4-nitrophenyl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.023
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(4-sulfamoylphenyl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.081
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(morpholin-4-yl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0081
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(pyridin-2-yl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00035
N-hydroxy-N3-[(4-[[(4-methoxyphenyl)carbamoyl]amino]phenyl)sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0023
N-hydroxy-N3-[2-(3-methoxyphenyl)ethyl]-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00006
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-([4-[(methylcarbamoyl)amino]phenyl]sulfonyl)-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00001
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-([4-[(phenoxycarbamoyl)amino]phenyl]sulfonyl)-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000093
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-([4-[(phenylcarbamoyl)amino]phenyl]sulfonyl)-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.001
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00003
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[(4-[[(2-phenylethyl)carbamoyl]amino]phenyl)sulfonyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0091
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[[2-(methylsulfonyl)phenyl]sulfonyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00029
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[[4-(methylsulfonyl)phenyl]sulfonyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000042
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[[4-([[4-(trifluoromethyl)phenyl]carbamoyl]amino)phenyl]sulfonyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0071
N-hydroxy-N3-[[2-(N'-hydroxycarbamimidoyl)phenyl]sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0004
N-hydroxy-N3-[[3-(N'-hydroxycarbamimidoyl)phenyl]sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00008
N-hydroxy-N3-[[4-(N'-hydroxycarbamimidoyl)phenyl]sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000021
N-[(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)carbonyl]glycine
Homo sapiens
-
-
1.5
N-[(hydroxyamino)methyl]-L-alpha-aspartyl-N-methyl-L-alpha-glutamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0094
N-[2-(4-methoxyphenyl)ethyl]-4-(methylsulfonyl)-N-(2-sulfanylethyl)benzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
0.014
N-[2-(4-methoxyphenyl)ethyl]-4-(methylsulfonyl)-N-(3-sulfanylpropyl)benzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
0.1
N-[2-[carbamoyl(hydroxy)amino]ethyl]-N-[2-(4-methoxyphenyl)ethyl]-4-(methylsulfonyl)benzenesulfonamide
Homo sapiens
-
above, pH and temperature not specified in the publication
0.019
N2-(4-chlorobenzyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.034
N2-(4-fluorobenzyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.055
N2-(butylsulfonyl)-N-hydroxy-N2-[2-(4-methoxyphenyl)ethyl]glycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.102
N2-(diphenylmethyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0028
N2-benzyl-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-L-alpha-asparagine
Homo sapiens
-
pH and temperature not specified in the publication
0.016
N2-benzyl-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.112
N2-butan-2-yl-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0047
N2-[2-(4-methoxyphenyl)ethyl]-N2-[[4-(methylsulfonyl)phenyl]sulfonyl]-N-sulfanylglycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.04
N2-[2-(carboxymethyl)-4-(hydroxyamino)-4-oxobutanoyl]-N-methyl-L-alpha-glutamine
Homo sapiens
-
pH and temperature not specified in the publication
0.085
N2-[3-carboxy-2-(sulfanylmethyl)propanoyl]-N-methyl-L-alpha-glutamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0067
N3-(butylsulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.001
N3-(cyclohexylmethyl)-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000073
N3-([4-[(biphenyl-4-ylcarbamoyl)amino]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00038
N3-([4-[(diphenoxycarbamoyl)amino]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00078
N3-([4-[(diphenylcarbamoyl)amino]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00047
N3-([4-[amino(phenylsulfonyl)methyl]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0045
N3-benzyl-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0017
N3-butan-2-yl-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.017
N3-[(4-tert-butylphenyl)sulfonyl]-N-hydroxy-N3-(2-phenylethyl)-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0003
N3-[(4-[[(4-chlorophenyl)carbamoyl]amino]phenyl)sulfonyl]-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.042
N3-[2-(3,4-dimethoxyphenyl)ethyl]-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.013
N3-[2-(4-methoxyphenyl)ethyl]-N3-[[4-(methylsulfonyl)phenyl]sulfonyl]-N-sulfanyl-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000026
phenyl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
Homo sapiens
-
-
0.000107
pyridin-2-yl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
Homo sapiens
-
-
0.000026
pyridin-3-yl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
Homo sapiens
-
-
0.345
[[2-(hydroxyamino)-2-oxoethyl][(4-methoxyphenyl)sulfonyl]amino]acetic acid
Homo sapiens
-
pH and temperature not specified in the publication
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
gastric epithelial adenocarcinoma stimulated with Helicobacter pylori
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
physiological function
malfunction
-
angiogenesis is inhibited by blocking the activity of procollagen C-endopeptidase
malfunction
-
Inhibition of the enzyme is expected to disrupt fibril formation and stability, preventing the excess collagen deposition associated with fibrosis
physiological function
-
BMP-1 is one of two key enzymes crucial for conversion of fibrillar procollagens to self-assembling collagen monomers which plays a crucial role in the formation of new blood vessels, maintenance of their growth, and in the formation of skeletal components during tissue development
physiological function
-
bone morphogenic protein 1 is a multisubstrate enzyme essential to the formation of extracellular matrix, via direct interaction with its substrate procollagen
physiological function
-
types I-III collagens are initially excreted as pro-collagen peptides which contain solubilizing N and C terminal sequences. The enzyme cleaves both pro-collagen and non-collagen substrates involved in forming functional collagen fibrils. Cleavage of the globular C-terminal sequence is necessary to convert soluble pro-collagens into fully formed, insoluble, collagen fibrils. In addition, PCP processes prolysyl oxidase to its active form, which catalyzes the crosslinking of collagens, contributing to the structural stability of collagen fibrils
physiological function
the C-terminal processing of procollagen type I by bone morphogenetic protein 1, BMP-1, the major procollagen C-proteinase, is a reaction stimulated by the connective tissue glycoprotein procollagen C-proteinase enhancer 1 (PCPE-1), kinetic constants
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). BMP1_HUMAN
986
0
111249
Swiss-Prot
Secretory Pathway (Reliability: 2)
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
the most NH2-terminal CUB domain (CUB1) is not required for BMP1 secretion nor is the next CUB domain (CUB2) required for enzymatic activity. Secreted protease domain of BMP1, devoid of CUB or epidermal growth factor-like domains, have procollagen C-proteinase activity and activity for biosynthetic processing of biglycan, the latter with kinetics superior to those of the full-length proteins
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in baculovirus-infected Sf21 insect cells, HT-180 cells, 293-EBNA cells or COS-7 cells
-
recombinant enzyme expression in insect cells using the baculovirus transfection system
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
-
the serum procollagen C-proteinase enhancer 1 glycopattern is associated with the physiological and pathological states of bone
additional information
-
involved in deposition of collagen fibrils in the extracellular matrix following processing of procollagen propeptides, dorsoventral patterning through cleavage of chordin, collagen and elastin cross-linking by processing of inactive precursors of lysyl oxidases, proteoglycan maturation and assembly of the dermal-epidermal junction by processing of laminin 5 chains and cleaving the C-propeptide of type VII procollagen
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Garrigue-Antar, L.; Barker, C.; Kadler, K.E.
Identification of amino acid residues in bone morphogenetic protein-1 important for procollagen C-proteinase activity
J. Biol. Chem.
276
26237-26242
2001
Homo sapiens (P13497)
Hartigan, N.; Garrigue-Antar, L.; Kadler, K.E.
Bone morphogenetic protein-1 (BMP-1). Identification of the minimal domain structure for procollagen C-proteinase activity
J. Biol. Chem.
278
18045-18049
2003
Homo sapiens (P13497)
Hintze, V.; Hoewel, M.; Wermter, C.; Grosse Berkhoff, E.; Becker-Pauly, C.; Beermann, B.; Yiallouros, I.; Stoecker, W.
The interaction of recombinant subdomains of the procollagen C-proteinase with procollagen I provides a quantitative explanation for functional differences between the two splice variants, mammalian tolloid and bone morphogenetic protein 1
Biochemistry
45
6741-6748
2006
Homo sapiens
Kessler, E.
Procollagen C-endopeptidase
Handbook of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press
1
609-617
2004
Gallus gallus, Homo sapiens, Mus musculus, Rattus norvegicus, Strongylocentrotus purpuratus, Xenopus laevis
-
Moali, C.; Font, B.; Ruggiero, F.; Eichenberger, D.; Rousselle, P.; Francois, V.; Oldberg, A.; Bruckner-Tuderman, L.; Hulmes, D.J.
Substrate-specific modulation of a multisubstrate proteinase. C-terminal processing of fibrillar procollagens is the only BMP-1-dependent activity to be enhanced by PCPE-1
J. Biol. Chem.
280
24188-24194
2005
Homo sapiens
Wermter, C.; Hoewel, M.; Hintze, V.; Bombosch, B.; Aufenvenne, K.; Yiallouros, I.; Stoecker, W.
The protease domain of procollagen C-proteinase (BMP1) lacks substrate selectivity, which is conferred by non-proteolytic domains
Biol. Chem.
388
513-521
2007
Homo sapiens
Ge, G.; Zhang, Y.; Steiglitz, B.M.; Greenspan, D.S.
Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains
J. Biol. Chem.
281
10786-10798
2006
Homo sapiens
Fish, P.V.; Allan, G.A.; Bailey, S.; Blagg, J.; Butt, R.; Collis, M.G.; Greiling, D.; James, K.; Kendall, J.; McElroy, A.; McCleverty, D.; Reed, C.; Webster, R.; Whitlock, G.A.
Potent and selective nonpeptidic inhibitors of procollagen C-proteinase
J. Med. Chem.
50
3442-3456
2007
Homo sapiens
Lesiak, M.; Augusciak-Duma, A.; Szydlo, A.; Pruszczynska, K.; Sieron, A.L.
Specific inhibition of procollagen C-endopeptidase activity by synthetic peptide with conservative sequence found in chordin
Acta Biochim. Pol.
55
297-305
2008
Homo sapiens (P13497)
Bailey, S.; Fish, P.V.; Billotte, S.; Bordner, J.; Greiling, D.; James, K.; McElroy, A.; Mills, J.E.; Reed, C.; Webster, R.
Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents
Bioorg. Med. Chem. Lett.
18
6562-6567
2008
Homo sapiens
Mesilaty-Gross, S.; Anikster, Y.; Vilensky, B.; Wolf, I.; Phillip, M.; Gat-Yablonski, G.
Different patterns of human serum procollagen C-proteinase enhancer1 (PCPE1)
Clin. Chim. Acta
403
76-80
2009
Homo sapiens
Kronenberg, D.; Vadon-Le Goff, S.; Bourhis, J.M.; Font, B.; Eichenberger, D.; Hulmes, D.J.; Moali, C.
Strong cooperativity and loose geometry between CUB domains are the basis for procollagen C-proteinase enhancer activity
J. Biol. Chem.
284
33437-33446
2009
Homo sapiens
Bekhouche, M.; Kronenberg, D.; Vadon-Le Goff, S.; Bijakowski, C.; Lim, N.H.; Font, B.; Kessler, E.; Colige, A.; Nagase, H.; Murphy, G.; Hulmes, D.J.; Moali, C.
Role of the netrin-like domain of procollagen C-proteinase enhancer-1 in the control of metalloproteinase activity
J. Biol. Chem.
285
15950-15959
2010
Homo sapiens
Zhu, J.; Gardner, J.; Pullinger, C.R.; Kane, J.P.; Thompson, J.F.; Francone, O.L.
Regulation of apoAI processing by procollagen C-proteinase enhancer-2 and bone morphogenetic protein-1
J. Lipid Res.
50
1330-1339
2009
Homo sapiens
Lesiak, M.; Augusciak-Duma, A.; Szydlo, A.; Sieron, A.L.
Blocking angiogenesis with peptides that inhibit the activity of procollagen C-endopeptidase
Pharmacol. Rep.
61
468-476
2009
Homo sapiens
Vadon-Le Goff, S.; Kronenberg, D.; Bourhis, J.M.; Bijakowski, C.; Raynal, N.; Ruggiero, F.; Farndale, R.W.; Stoecker, W.; Hulmes, D.J.; Moali, C.
Procollagen C-proteinase enhancer stimulates procollagen processing by binding to the C-propeptide region only
J. Biol. Chem.
286
38932-38938
2011
Homo sapiens
Turtle, E.; Chow, N.; Yang, C.; Sosa, S.; Bauer, U.; Brenner, M.; Solow-Cordero, D.; Ho, W.B.
Design and synthesis of procollagen C-proteinase inhibitors
Bioorg. Med. Chem. Lett.
22
7397-7401
2012
Homo sapiens
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