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Information on EC 3.4.23.B10 - Rous sarcoma virus retropepsin

for references in articles please use BRENDA:EC3.4.23.B10
preliminary BRENDA-supplied EC number
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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.B10 Rous sarcoma virus retropepsin
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
The cleavage sequence in the natural substrate NC-PR is PPAVS-/-LAMTMRR. The activity can be improved by substitution by Trp, Tyr, Phe, Leu, Arg, Glu, His or Ala in P1, Tyr in P3', and Arg, Phe, Asn or His in P3
Synonyms
viral protease, gag polyprotein, p15 protein, rsv pr, core protein p19, protease p15, rsv protease, rous sarcoma virus protease, capsid protein p27, amv pr, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
The cleavage sequence in the natural substrate NC-PR is PPAVS-/-LAMTMRR. The activity can be improved by substitution by Trp, Tyr, Phe, Leu, Arg, Glu, His or Ala in P1, Tyr in P3', and Arg, Phe, Asn or His in P3
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