Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Abortion, Spontaneous
The expression of cathepsin D, oestrogen receptor and progestogen receptor in hydatidiform mole--an immunohistochemical study.
Acquired Immunodeficiency Syndrome
Aspartic peptidase inhibitors: implications in drug development.
Acquired Immunodeficiency Syndrome
Trehalose limits opportunistic mycobacterial survival during HIV co-infection by reversing HIV-mediated autophagy block.
Acromegaly
Human nasal septal cartilage: local distribution of different enzyme activities in healthy adults and acromegalic patients.
Acute Coronary Syndrome
Anaphylactic cardiovascular collapse and Kounis syndrome: systemic vasodilation or coronary vasoconstriction?
Acute Coronary Syndrome
Quest for novel cardiovascular biomarkers by proteomic analysis.
Acute Kidney Injury
Lack of Cathepsin D in the Renal Proximal Tubular Cells Resulted in Increased Sensitivity against Renal Ischemia/Reperfusion Injury.
Acute Kidney Injury
Lysosomal protease cathepsin D; a new driver of apoptosis during acute kidney injury.
Adenocarcinoma
Activation of cathepsin B, secreted by a colorectal cancer cell line requires low pH and is mediated by cathepsin D.
Adenocarcinoma
Adenosquamous carcinoma of the gall-bladder with gastric foveolar-type epithelium.
Adenocarcinoma
Cathepsin D activity in colorectal cancer.
Adenocarcinoma
Cathepsin D activity in human ovarian tissues and ovarian carcinoma.
Adenocarcinoma
Cathepsin D as a potential prognostic marker for lung adenocarcinoma.
Adenocarcinoma
Cathepsin D expression in colorectal adenocarcinomas and adenomas.
Adenocarcinoma
Cathepsin D expression in normal, hyperplastic and malignant endometrial tissue: an immunohistochemical analysis.
Adenocarcinoma
CD44 expression in colorectal cancer. An immunohistochemical study including correlation with cathepsin D immunoreactivity and some tumour clinicopathological features.
Adenocarcinoma
Cellular localisation by in situ hybridisation of cathepsin D, stromelysin 3, and urokinase plasminogen activator RNAs in breast cancer.
Adenocarcinoma
Clinicopathological significance of cathepsin D expression in gastric adenocarcinoma.
Adenocarcinoma
Comparative quantitative immunohistochemical and immunoradiometric determinations of cathepsin D in endometrial adenocarcinoma: predictors of tumor aggressiveness.
Adenocarcinoma
Correlation of tumor cytosol cathepsin D with differentiation and invasiveness of endometrial adenocarcinoma.
Adenocarcinoma
DNA and protein content as cellular biochemical parameters. A discussion with two examples: acid phosphatase and cathepsin D in rat liver and hepatoma and acid phosphatase in human breast normal tissue and adenocarcinoma.
Adenocarcinoma
Endometrial adenocarcinoma of endometrioid subtype with squamous differentiation: an immunohistochemical study of MIB-1 (ki-67 paraffin), cathepsin D, and C-erbB-2 protein (p185).
Adenocarcinoma
Evaluation of cathepsin D immunostaining in colorectal adenocarcinoma.
Adenocarcinoma
Expression of cathepsin D and galectin 3 in tubular carcinomas of the breast.
Adenocarcinoma
Expression of cathepsin D in colorectal adenocarcinomas: Correlation with clinicopathologic features.
Adenocarcinoma
Immuno-histochemical evaluation of Cathepsin D in malignant salivary gland carcinomas.
Adenocarcinoma
Immunohistochemical evaluation of cathepsin D expression in colorectal cancer.
Adenocarcinoma
Immunohistochemical evaluation of cathepsin D expression in colorectal tumours: a correlation with extracellular matrix components, p53, pRb, bcl-2, c-erbB-2, EGFR and proliferation indices.
Adenocarcinoma
Immunohistochemical evaluation of tissue-specific proteolytic enzymes in adenomas containing foci of early carcinoma: correlations with cathepsin D expression and other malignant features.
Adenocarcinoma
Intracytoplasmic localization of cathepsin D reflects the invasive potential of gastric carcinoma.
Adenocarcinoma
Ki-67 staining in benign, borderline, malignant primary and metastatic ovarian tumors: correlation with steroid receptors, epidermal-growth-factor receptor and cathepsin D.
Adenocarcinoma
Lipofuscin pigment can be used as a prognostic marker in prostatic adenocarcinoma.
Adenocarcinoma
Low levels of cathepsin D are associated with a poor prognosis in endometrial cancer.
Adenocarcinoma
Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer.
Adenocarcinoma
Proteomic screening of a cell line model of esophageal carcinogenesis identifies cathepsin D and aldo-keto reductase 1C2 and 1B10 dysregulation in Barrett's esophagus and esophageal adenocarcinoma.
Adenocarcinoma
Serum CA19-9, cathepsin D, and matrix metalloproteinase-7 as a diagnostic panel for pancreatic ductal adenocarcinoma.
Adenocarcinoma
Significance of estrogen receptors and cathepsin D tissue detection in gastric adenocarcinoma.
Adenocarcinoma
[Prognostic value of molecular biologogy and immunologic parameters in human pancreatic carcinoma]
Adenocarcinoma of Lung
Cathepsin D as a potential prognostic marker for lung adenocarcinoma.
Adenocarcinoma of Lung
Influence of cathepsin D expression in lung adenocarcinoma on prognosis: possible importance of its expression in tumor cells and stromal cells, and its intracellular polarization in tumor cells.
Adenocarcinoma of Lung
Proteomic study of malignant pleural mesothelioma by laser microdissection and two-dimensional difference gel electrophoresis identified cathepsin D as a novel candidate for a differential diagnosis biomarker.
Adenocarcinoma of Lung
[CYFRA 21.1 cytosol levels in lung adenocarcinomas. Correlation with other clinico-biological parameters]
Adenoma
Cathepsin B and Cathepsin D Expression in Follicular Adenomas and Carcinomas of the Thyroid Gland.
Adenoma
Cathepsin B and cathepsin D expression in the progression of colorectal adenoma to carcinoma.
Adenoma
Cathepsin D expression in colorectal adenocarcinomas and adenomas.
Adenoma
DNA measurement, proliferation markers, and other factors in pituitary adenomas.
Adenoma
Estrogen receptors and cathepsin D in human thyroid tissue.
Adenoma
Expression of hypoxia-inducible factor 1alpha and cathepsin D in pituitary adenomas.
Adenoma
Expression, localization, and thyrotropin regulation of cathepsin D in human thyroid tissues.
Adenoma
Glycoprotein CD44 expression in colorectal neoplasms. An immuno-histochemical study including correlation with cathepsin D, extracellular matrix components, p53, Rb, bcl-2, c-erbB-2, EGFR and proliferation indices.
Adenoma
Immunohistochemical evaluation of cathepsin D expression in colorectal tumours: a correlation with extracellular matrix components, p53, pRb, bcl-2, c-erbB-2, EGFR and proliferation indices.
Adenoma
Immunohistochemical evaluation of tissue-specific proteolytic enzymes in adenomas containing foci of early carcinoma: correlations with cathepsin D expression and other malignant features.
Adenoma
Intracytoplasmic localization of cathepsin D reflects the invasive potential of gastric carcinoma.
Adenoma
Proliferation Markers and EGF in ACTH-Secreting Adenomas and Carcinomas of the Pituitary.
Aggressive Periodontitis
Amplified crevicular leukocyte activity in aggressive periodontal disease.
Alzheimer Disease
A beta-amyloid peptide variant related with familial Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis is poorly eliminated by cathepsin D.
Alzheimer Disease
A genetic variation of cathepsin D is a major risk factor for Alzheimer's disease.
Alzheimer Disease
A high-resolution linkage map for comparative genome analysis and QTL fine mapping in Asian seabass, Lates calcarifer.
Alzheimer Disease
A Novel Approach for Characterization of Cathepsin D Protease and Its Effect on Tau and ?-Amyloid Proteins.
Alzheimer Disease
A Novel Dual Fluorochrome Near-Infrared Imaging Probe for Potential Alzheimer's Enzyme Biomarkers-BACE1 and Cathepsin D.
Alzheimer Disease
A paramagnetic chemical exchange-based MRI probe metabolized by cathepsin D: design, synthesis and cellular uptake studies.
Alzheimer Disease
Abnormal distribution of cathepsins in the brain of patients with Alzheimer's disease.
Alzheimer Disease
ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease.
Alzheimer Disease
Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D.
Alzheimer Disease
An Alzheimer's Disease-Linked Loss-of-Function CLN5 Variant Impairs Cathepsin D Maturation, Consistent with a Retromer Trafficking Defect.
Alzheimer Disease
Aspartic peptidase inhibitors: implications in drug development.
Alzheimer Disease
Association between cathepsin D polymorphism and Alzheimer's disease in a Chinese Han population.
Alzheimer Disease
Association Study of Cathepsin D Gene Polymorphism in Iranian Patients with Sporadic Late-Onset Alzheimer's Disease.
Alzheimer Disease
Candidate gamma-secretases in the generation of the carboxyl terminus of the Alzheimer's disease beta A4 amyloid: possible involvement of cathepsin D.
Alzheimer Disease
Cathepsin D as a therapeutic target in Alzheimer's disease.
Alzheimer Disease
Cathepsin D displays in vitro beta-secretase-like specificity.
Alzheimer Disease
Cathepsin D expression is decreased in Alzheimer's disease fibroblasts.
Alzheimer Disease
Cathepsin D from Alzheimer's-diseased and normal brains.
Alzheimer Disease
Cathepsin D gene and the risk of Alzheimer's disease: A population-based study and meta-analysis.
Alzheimer Disease
Cathepsin D gene exon 2 polymorphism and sporadic Alzheimer's disease.
Alzheimer Disease
Cathepsin D polymorphism in Italian elderly subjects with sporadic late-onset Alzheimer's disease.
Alzheimer Disease
Cathepsin D polymorphism in Italian sporadic and familial Alzheimer's disease.
Alzheimer Disease
Cathepsin D polymorphism not associated with Alzheimer's disease in Japanese.
Alzheimer Disease
Cathepsin D regulates cerebral A?42/40 ratios via differential degradation of A?42 and A?40.
Alzheimer Disease
Cathepsin D SNP associated with increased risk of variant Creutzfeldt-Jakob disease.
Alzheimer Disease
Cathepsin D: A Candidate Link between Amyloid ?-protein and Tauopathy in Alzheimer Disease.
Alzheimer Disease
Cathepsin D: screening for new polymorphisms using single-strand conformation polymorphism analysis.
Alzheimer Disease
Cerebellar dysfunction in a family harboring the PSEN1 mutation co-segregating with a Cathepsin D variant p.A58V.
Alzheimer Disease
Cerebrospinal fluid levels of beta-amyloid(42) in patients with Alzheimer's disease are related to the exon 2 polymorphism of the cathepsin D gene.
Alzheimer Disease
Colocalization of lysosomal hydrolase and beta-amyloid in diffuse plaques of the cerebellum and striatum in Alzheimer's disease and Down's syndrome.
Alzheimer Disease
Comparison of cathepsin protease activities in brain tissue from normal cases and cases with Alzheimer's disease, Lewy body dementia, Parkinson's disease and Huntington's disease.
Alzheimer Disease
Comprehensive Exploration of Target-specific Ligands Using a Graph Convolution Neural Network.
Alzheimer Disease
Contribution of apolipoprotein E and cathepsin D genotypes to the familial aggregation of Alzheimer's disease.
Alzheimer Disease
Cortical cathepsin D activity and immunolocalization in Alzheimer disease, critical coronary artery disease, and aging.
Alzheimer Disease
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Alzheimer Disease
Decreased Expression of Cathepsin D in Monocytes is Related to the Defective Degradation of Amyloid-? in Alzheimer's Disease.
Alzheimer Disease
Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, ?-site amyloid precursor protein cleaving enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation.
Alzheimer Disease
Design of sensitive fluorogenic substrates for human cathepsin D.
Alzheimer Disease
Effect of Temperature and pH on the Secondary Structure and Denaturation Process of Jumbo Squid Hepatopancreas Cathepsin D.
Alzheimer Disease
Electroacupuncture ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer disease via a novel mechanism involving activation of TFEB (transcription factor EB).
Alzheimer Disease
Elevated levels of the endosomal-lysosomal proteinase cathepsin D in cerebrospinal fluid in Alzheimer disease.
Alzheimer Disease
Evaluation of cathepsins D and G and EC 3.4.24.15 as candidate beta-secretase proteases using peptide and amyloid precursor protein substrates.
Alzheimer Disease
Expression and characterization of human beta-secretase candidates metalloendopeptidase MP78 and cathepsin D in beta APP-overexpressing cells.
Alzheimer Disease
Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system.
Alzheimer Disease
Genetic associations between cathepsin D exon 2 C-->T polymorphism and Alzheimer's disease, and pathological correlations with genotype.
Alzheimer Disease
Genetic polymorphism in exon 2 of cathepsin D is not associated with vascular dementia.
Alzheimer Disease
Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease.
Alzheimer Disease
Identification of Cathepsin D as a Plasma Biomarker for Alzheimer's Disease.
Alzheimer Disease
In vitro processing of amyloid precursor protein by cathepsin D.
Alzheimer Disease
Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities.
Alzheimer Disease
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.
Alzheimer Disease
Lack of association between cathepsin D C224T polymorphism and Alzheimer's disease risk: an update meta-analysis.
Alzheimer Disease
Lack of association between cathepsin D genetic polymorphism and Alzheimer disease in a Spanish sample.
Alzheimer Disease
Lack of association of cathepsin D genetic polymorphism with Alzheimer's disease in Koreans.
Alzheimer Disease
Lysosomal cathepsin D is upregulated in Alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration.
Alzheimer Disease
Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.
Alzheimer Disease
Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin.
Alzheimer Disease
Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease.
Alzheimer Disease
Meta-analysis of the association of the cathepsin D Ala224Val gene polymorphism with the risk of Alzheimer's disease: a HuGE gene-disease association review.
Alzheimer Disease
Modulation of disease risk according to a cathepsin D / apolipoprotein E genotype in Parkinson's disease.
Alzheimer Disease
Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes.
Alzheimer Disease
New cathepsin d inhibitors with hydroxyethylamine isosteres: preparation and characterization.
Alzheimer Disease
New insights into the roles of endolysosomal cathepsins in the pathogenesis of Alzheimer's disease: cathepsin inhibitors as potential therapeutics.
Alzheimer Disease
No evidence for genetic association or linkage of the cathepsin D (CTSD) exon 2 polymorphism and Alzheimer disease.
Alzheimer Disease
Non-replication of association between cathepsin D genotype and late onset Alzheimer disease.
Alzheimer Disease
Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus.
Alzheimer Disease
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Alzheimer Disease
Oxidative imbalance and cathepsin D changes as peripheral blood biomarkers of Alzheimer disease: a pilot study.
Alzheimer Disease
PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma.
Alzheimer Disease
Positive Association of the Cathepsin D Ala224Val Gene Polymorphism With the Risk of Alzheimer's Disease.
Alzheimer Disease
Processing of the pre-beta-amyloid protein by cathepsin D is enhanced by a familial Alzheimer's disease mutation.
Alzheimer Disease
Prolonged In Vivo Retention of a Cathepsin D Targeted Optical Contrast Agent in a Mouse Model of Alzheimer's Disease.
Alzheimer Disease
Putative association of polymorphism in the mannose 6-phosphate receptor gene with major depression and Alzheimer's disease.
Alzheimer Disease
Quantitative decrease in synaptophysin message expression and increase in cathepsin D message expression in Alzheimer disease neurons containing neurofibrillary tangles.
Alzheimer Disease
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Alzheimer Disease
Short arm of chromosome 11 and sporadic Alzheimer's disease: catalase and cathepsin D gene polymorphisms.
Alzheimer Disease
Significance of cytosolic cathepsin D in Alzheimer's disease pathology: Protective cellular effects of PLGA nanoparticles against ?-amyloid-toxicity.
Alzheimer Disease
Spatial patterns of mammalian brain aging: distribution of cathepsin D-immunoreactive cell bodies and dystrophic dendrites in aging dogs resembles that in Alzheimer's disease.
Alzheimer Disease
Structure-based subsite specificity mapping of human cathepsin D using statine-based inhibitors.
Alzheimer Disease
Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors.
Alzheimer Disease
The cathepsin D (224C/T) polymorphism confers an increased risk to develop Alzheimer's disease in men.
Alzheimer Disease
The cathepsin D gene exon 2 (C224T) polymorphism and sporadic Alzheimer's disease in European populations.
Alzheimer Disease
The cathepsin D rs17571 polymorphism: effects on CSF tau concentrations in Alzheimer disease.
Alzheimer Disease
The genetic association between Cathepsin D and Alzheimer's disease.
Alzheimer Disease
Uptake and pathogenic effects of amyloid beta peptide 1-42 are enhanced by integrin antagonists and blocked by NMDA receptor antagonists.
Alzheimer Disease
[The C224T polymorphism in the cathepsin D gene is not associated with sporadic Alzheimer's disease in Chinese]
Amyloidosis
A beta-amyloid peptide variant related with familial Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis is poorly eliminated by cathepsin D.
Amyloidosis
Activities of lysosomal enzymes and levels of serum amyloid A (SAA) in blood plasma of hamsters during casein induction of AA-amyloidosis.
Amyloidosis
Haplodeficiency of Cathepsin D does not affect cerebral amyloidosis and autophagy in APP/PS1 transgenic mice.
Amyloidosis
Hereditary cerebral hemorrhage with amyloidosis (Dutch): a model for congophilic plaque formation without neurofibrillary pathology.
Amyloidosis
In vitro degradation of serum amyloid A by cathepsin D and other acid proteases: possible protection against amyloid fibril formation.
Amyloidosis
Proteome analysis of cerebrospinal fluid in Guillain-Barré syndrome (GBS).
Amyloidosis
The effect of beta aminoproprionitrile (BAPN) on experimental amyloidosis.
Amyotrophic Lateral Sclerosis
Lysosomal and nonlysosomal hydrolases of skeletal muscle in neuromuscular diseases.
Amyotrophic Lateral Sclerosis
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Amyotrophic Lateral Sclerosis
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Amyotrophic Lateral Sclerosis
Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43.
Anaphylaxis
Anaphylactic cardiovascular collapse and Kounis syndrome: systemic vasodilation or coronary vasoconstriction?
Anaplasia
Association between high concentrations of Mr 52,000 cathepsin D and poor prognosis in primary human breast cancer.
Anaplasia
Expression of cathepsin D in human astrocytic neoplasias.
Anemia
Antianaemic properties of ayurvedic drugs, raktavardhak, punarnavasav and navayas louh in albino rats during phenylhydrazine induced haemolytic anaemia.
Aneurysm
Activity of enzymes with different subcellular localization in the blood plasma of patients with aortic aneurysm.
Aneurysm
Cathepsin D and cathepsin L activities in aortic aneurysm wall and parietal thrombus.
Angina Pectoris
Beneficial effects of ibuprofen in pacing-induced myocardial ischemia.
Aortic Aneurysm
Activity of enzymes with different subcellular localization in the blood plasma of patients with aortic aneurysm.
Aortic Aneurysm
Cathepsin D and cathepsin L activities in aortic aneurysm wall and parietal thrombus.
Aortic Aneurysm
[Concentration and activity of cathepsin D in the blood plasma and serum of patients with abdominal aortic aneurysm]
Aortic Aneurysm, Abdominal
[Concentration and activity of cathepsin D in the blood plasma and serum of patients with abdominal aortic aneurysm]
Arthritis
Effect of bioflavonoids on lysosomal acid hydrolases and lysosomal stability in adjuvant-induced arthritis.
Arthritis
Experimental arthritis of rabbits caused by intra-articular injection of autologous Fab2 produced by digestion of IgG with cathepsin D.
Arthritis
Experimental arthritis of rabbits caused by intra-articular injection of autologous Fab2 produced by digestion of IgG with cathepsin D. II. Microscopical and immunohistochemical findings in long-term experiments.
Arthritis
The secretion of enzymes into the pericellular environment.
Arthritis
[Role of cathepsin D of synovial fluid of the knee joint in the pathogenesis of traumatic arthritis]
Arthritis, Reactive
[Role of cathepsin D of synovial fluid of the knee joint in the pathogenesis of traumatic arthritis]
Arthritis, Rheumatoid
Anti-inflammatory activity of Jasminum grandiflorum L. subsp. floribundum (Oleaceae) in inflammatory bowel disease and arthritis models.
Arthritis, Rheumatoid
Cathepsin D agglutinators and neutral protease agglutinators in rheumatoid arthritis. II. Production of CDA and NPA by rheumatoid synovium and phagocytosis of CDA by synovial phagocytic cells.
Arthritis, Rheumatoid
Cathepsin D agglutinators in rheumatoid arthritis. I. Increased CDA titers in serum and synovial fluid of patients with seropositive RA.
Arthritis, Rheumatoid
Comparative analysis of cathepsin L, cathepsin D, and collagenase messenger RNA expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis, by in situ hybridization.
Arthritis, Rheumatoid
Comparative analysis of hexosaminidase and cathepsin D expression in synovial fluid of patients with rheumatoid arthritis and traumatized joints.
Arthritis, Rheumatoid
Lysosomal peptidases and glycosidases in rheumatoid arthritis.
Arthus Reaction
Failure of complete in vivo inhibition of cathepsin D to mitigate the pulmonary arthus reaction.
arylsulfatase (type i) deficiency
Enhanced breakdown of arylsulfatase A in multiple sulfatase deficiency.
Astrocytoma
Cathepsin D is a potential serum marker for poor prognosis in glioma patients.
Astrocytoma
Distribution of Lysosome-associated Membrane Proteins-1 and -2, and Cathepsin D in Eosinophilic Granular Bodies: Possible Relationship to Cyst Development in Pilocytic Astrocytomas.
Astrocytoma
Expression of cathepsin D during the progression of human gliomas.
Astrocytoma
Matrix metalloproteinase-9 interplays with the IGFBP2-IGFII complex to promote cell growth and motility in astrocytomas.
Ataxia
Cathepsin D deficiency causes juvenile-onset ataxia and distinctive muscle pathology.
Atherosclerosis
Cancer biomarkers in atherosclerotic plaque: Evidenced from structural and proteomic analyses.
Atherosclerosis
Correlation between cathepsin D serum concentration and carotid intima-media thickness in hemodialysis patients.
Atherosclerosis
Evaluation of serum cathepsin D concentrations in coronary artery disease.
Atherosclerosis
Relation between serum cathepsin D levels and endothelial dysfunction in patients with chronic kidney disease.
Atherosclerosis
Significances of viable synergistic autophagy-associated cathepsin B and cathepsin D (CTSB/CTSD) as potential biomarkers for sudden cardiac death.
Autoimmune Diseases
Cathepsin D-like activity in serum of patients with systemic lupus erythematosus.
Azoospermia
TDRD7 participates in lens development and spermiogenesis by mediating autophagosome maturation.
Bacterial Infections
Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation.
Bacterial Infections
Cloning and expression analysis of cathepsin D in the olive flounder Paralichthys olivaceus.
Bacterial Infections
Molecular characterization and expression analysis of the channel catfish cathepsin D genes.
Bacterial Infections
Molecular cloning, characterization and expression of cathepsin D from grass carp (Ctenopharyngodon idella).
Barrett Esophagus
Proteomic screening of a cell line model of esophageal carcinogenesis identifies cathepsin D and aldo-keto reductase 1C2 and 1B10 dysregulation in Barrett's esophagus and esophageal adenocarcinoma.
Bone Cysts
The role of lysosomes in the pathogenesis of unicameral bone cysts.
Bone Resorption
Attenuation of adjuvant-induced arthritis by dietary sesamol via modulation of inflammatory mediators, extracellular matrix degrading enzymes and antioxidant status.
Bone Resorption
Giant-cell tumors of bone and progesterone receptors.
Bone Resorption
Immunocytochemical localization of cathepsin D in the rat osteoclast.
Bowen's Disease
Cathepsin B and D expression in squamous cell carcinoma.
Brain Edema
Changes of perivascular macrophages in the process of brain edema induced by cold injury.
Brain Injuries
Autophagic neuron death.
Brain Injuries, Traumatic
Immunoblot analyses of the relative contributions of cysteine and aspartic proteases to neurofilament breakdown products following experimental brain injury in rats.
Brain Injuries, Traumatic
PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma.
Brain Neoplasms
Cathepsin D and its prognostic value in neuroepithelial brain tumors.
Breast Cyst
Cathepsin D and epidermal growth factor in human breast cyst fluid.
Breast Cyst
Quantification and molecular analysis of cathepsin D in breast cyst fluids.
Breast Cyst
[Levels of Cathepsin D in breast cyst fluid]
Breast Diseases
A two-site immunoenzymometric assay of 52-kDa pro-cathepsin D, and its use in human breast diseases.
Breast Diseases
Analysis of breast-tissue cathepsin-d isoforms from patients with breast-cancer, benign breast disease and from normal controls.
Breast Diseases
Analysis of cathepsin D in human breast cancer: usefulness of the processed 31 kDa active form of the enzyme as a prognostic indicator in node-negative and node-positive patients.
Breast Diseases
Cathepsin D in breast secretions from women with breast cancer.
Breast Diseases
Cathepsin-D expression in breast lesion: an immunohistochemical study.
Breast Diseases
Dissociated overexpression of cathepsin D and estrogen receptor alpha in preinvasive mammary tumors.
Breast Diseases
Progestin treatment depresses estrogen receptor but not cathepsin D levels in needle aspirates of benign breast disease.
Breast Diseases
Receiver-operating characteristic (ROC) curve analysis of cathepsin D and pS2 in breast disease; results from a prospective study.
Breast Diseases
Western blotting and enzymatic activity analysis of cathepsin D in breast tissue and sera of patients with breast cancer and benign breast disease and of normal controls.
Breast Neoplasms
3,3'4,4'-Tetrachlorobiphenyl exhibits antiestrogenic and antitumorigenic activity in the rodent uterus and mammary cells and in human breast cancer cells.
Breast Neoplasms
A hormone-regulated pro-cathepsin D secreted by human mammary cancer cells.
Breast Neoplasms
A lysosomal pepstatin-insensitive proteinase as a novel biomarker for breast carcinoma.
Breast Neoplasms
A multiparametric study on the prognostic value of epidermal growth factor receptor in operable breast carcinoma.
Breast Neoplasms
A novel aspartic protease gene, ALP56, is up-regulated in human breast cancer independently from the cathepsin D gene.
Breast Neoplasms
A prospective study of the prognostic value of cathepsin D levels in breast cancer cytosol.
Breast Neoplasms
A two-site immunoenzymometric assay of 52-kDa pro-cathepsin D, and its use in human breast diseases.
Breast Neoplasms
Abnormal expression of four novel molecular markers represents a highly aggressive phenotype in breast cancer. Immunohistochemical assay of p53, nm23, erbB-2, and cathepsin D protein.
Breast Neoplasms
Activation of peripheral blood neutrophils and lymphocytes by human procathepsin D and insulin-like growth factor II.
Breast Neoplasms
Activity of cathepsin D and alpha(1)-antitrypsin in the blood serum of patients with mammary carcinoma.
Breast Neoplasms
Age-dependent changes in breast cancer hormone receptors and oxidant stress markers.
Breast Neoplasms
Alteration of cathepsin D trafficking induced by hypoxia and extracellular acidification in MCF-7 breast cancer cells.
Breast Neoplasms
Alterations and role of human cathepsin D in cancer metastasis.
Breast Neoplasms
An immunohistochemical assessment of cathepsin D in gastric carcinoma: its impact on clinical prognosis.
Breast Neoplasms
Analysis of breast-tissue cathepsin-d isoforms from patients with breast-cancer, benign breast disease and from normal controls.
Breast Neoplasms
Analysis of cathepsin D in human breast cancer: usefulness of the processed 31 kDa active form of the enzyme as a prognostic indicator in node-negative and node-positive patients.
Breast Neoplasms
Analysis of the interaction of procathepsin D activation peptide with breast cancer cells.
Breast Neoplasms
Aspartic peptidase inhibitors: implications in drug development.
Breast Neoplasms
Aspects of breast cancers.
Breast Neoplasms
Association between high concentrations of Mr 52,000 cathepsin D and poor prognosis in primary human breast cancer.
Breast Neoplasms
Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study.
Breast Neoplasms
Association of the 323/A3 surface glycoprotein with tumor characteristics and behavior in human breast cancer.
Breast Neoplasms
Autoantibodies to tumor-associated antigens in breast carcinoma.
Breast Neoplasms
Benzophenone-1 and nonylphenol stimulated MCF-7 breast cancer growth by regulating cell cycle and metastasis-related genes via an estrogen receptor ?-dependent pathway.
Breast Neoplasms
Biochemical parameters for prognostic evaluation in patients with breast cancer.
Breast Neoplasms
Biological and clinical relevance of the urokinase-type plasminogen activator (uPA) in breast cancer.
Breast Neoplasms
Biological and clinical significance of cathepsin D in breast cancer metastasis.
Breast Neoplasms
Biological and clinical significance of cathepsin D in breast cancer.
Breast Neoplasms
Biological heterogeneity of ER-positive breast cancers in the post-menopausal population.
Breast Neoplasms
Bisphenol AF-Induced Endogenous Transcription Is Mediated by ER? and ERK1/2 Activation in Human Breast Cancer Cells.
Breast Neoplasms
c-Myb regulates matrix metalloproteinases 1/9, and cathepsin D: implications for matrix-dependent breast cancer cell invasion and metastasis.
Breast Neoplasms
Capillary electrophoretic determination of cathepsin D activity using Oregon Green-labeled hemoglobin.
Breast Neoplasms
Catalytically inactive human cathepsin D triggers fibroblast invasive growth.
Breast Neoplasms
Cathepsin B, a prognostic indicator in lymph node-negative breast carcinoma patients: comparison with cathepsin D, cathepsin L, and other clinical indicators.
Breast Neoplasms
Cathepsin D and breast cancer.
Breast Neoplasms
Cathepsin D and breast cancer: useful?
Breast Neoplasms
Cathepsin D and epidermal growth factor in human breast cyst fluid.
Breast Neoplasms
Cathepsin D and prognosis in breast cancer.
Breast Neoplasms
Cathepsin D and prognosis in breast cancer: one piece of a larger puzzle?
Breast Neoplasms
Cathepsin D as a prognostic indicator for node-negative breast cancer patients using both immunoassays and enzymatic assays.
Breast Neoplasms
Cathepsin D as an indicator of clinical outcome in early breast carcinoma during the first 3 years of follow-up.
Breast Neoplasms
Cathepsin D assay in primary breast cancer and lymph nodes: relationship with c-myc, c-erb-B-2 and int-2 oncogene amplification and node invasiveness.
Breast Neoplasms
Cathepsin D by western blotting and immunohistochemistry: failure to confirm correlations with prognosis in node-negative breast cancer.
Breast Neoplasms
Cathepsin D concentration in breast cancer cytosols: correlation with biochemical, histological, and clinical findings.
Breast Neoplasms
Cathepsin D concentration in breast cancer cytosols: correlation with disease-free interval and overall survival.
Breast Neoplasms
Cathepsin D concentration in tumor cytosols improves the accuracy of prognostic evaluation of primary breast cancer.
Breast Neoplasms
Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling.
Breast Neoplasms
Cathepsin D detected by automated and quantitative immunohistochemistry in breast carcinomas: correlation with overall and disease free survival.
Breast Neoplasms
Cathepsin D enhances breast cancer invasion and metastasis through promoting hepsin ubiquitin-proteasome degradation.
Breast Neoplasms
Cathepsin D expression by cancer and stromal cells in breast cancer: an immunohistochemical study of 1348 cases.
Breast Neoplasms
Cathepsin D expression detected by immunohistochemistry has independent prognostic value in axillary node-negative breast cancer.
Breast Neoplasms
Cathepsin D expression in skin metastasis of breast cancer.
Breast Neoplasms
Cathepsin D expression levels in nongynecological solid tumors: clinical and therapeutic implications.
Breast Neoplasms
Cathepsin D gene is controlled by a mixed promoter, and estrogens stimulate only TATA-dependent transcription in breast cancer cells.
Breast Neoplasms
Cathepsin D gene of human MCF7 cells contains estrogen-responsive sequences in its 5' proximal flanking region.
Breast Neoplasms
Cathepsin D immunocytochemical assays in breast carcinomas: image analysis and correlation to prognostic factors.
Breast Neoplasms
Cathepsin D immunostaining in paraffin-embedded breast cancer cells and macrophages: correlation with cytosolic assay.
Breast Neoplasms
Cathepsin D in breast cancer cells can digest extracellular matrix in large acidic vesicles.
Breast Neoplasms
Cathepsin D in breast cancer tissue.
Breast Neoplasms
Cathepsin D in breast cancer.
Breast Neoplasms
Cathepsin D in breast cancer: a tissue marker associated with metastasis.
Breast Neoplasms
Cathepsin D in breast cancer: from molecular and cellular biology to clinical applications.
Breast Neoplasms
Cathepsin D in breast cancer: mechanisms and clinical applications, a 1999 overview.
Breast Neoplasms
Cathepsin D in breast secretions from women with breast cancer.
Breast Neoplasms
Cathepsin D in cancer metastasis: a protease and a ligand.
Breast Neoplasms
Cathepsin D in host stromal cells is associated with more highly vascular and aggressive invasive breast carcinoma.
Breast Neoplasms
Cathepsin D in host stromal cells, but not in tumor cells, is associated with aggressive behavior in node-negative breast cancer.
Breast Neoplasms
Cathepsin D in invasive ductal NOS breast carcinoma as defined by immunohistochemistry. No correlation with survival at 5 years.
Breast Neoplasms
Cathepsin D in invasive ductal NOS, medullary, lobular and mucinous breast carcinoma. An immunohistochemical study.
Breast Neoplasms
Cathepsin D in primary breast carcinoma: adverse prognosis is associated with expression of cathepsin D in stromal cells.
Breast Neoplasms
Cathepsin D inhibitors as potential therapeutics for breast cancer treatment: Molecular docking and bioevaluation against triple-negative and triple-positive breast cancers.
Breast Neoplasms
Cathepsin D is partly endocytosed by the LRP1 receptor and inhibits LRP1-regulated intramembrane proteolysis.
Breast Neoplasms
Cathepsin D levels in primary breast cancers: relationship with epidermal growth factor receptor, oestrogen receptor and axillary nodal status.
Breast Neoplasms
Cathepsin D may help in discriminating node-negative breast cancer patients at risk for local-regional recurrence.
Breast Neoplasms
Cathepsin D specifically cleaves the chemokines macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, and SLC that are expressed in human breast cancer.
Breast Neoplasms
Cathepsin D stimulates the activities of secreted plasminogen activators in the breast cancer acidic environment.
Breast Neoplasms
Cathepsin D versus other prognostic factors in breast cancer. Results and controversies of a multicenter study on 2575 cases.
Breast Neoplasms
Cathepsin D, both a prognostic factor and a predictive factor for the effect of adjuvant tamoxifen in breast cancer. South Sweden Breast Cancer Group.
Breast Neoplasms
Cathepsin D-related disease-free interval in pT1 primary breast carcinomas: a pilot study.
Breast Neoplasms
Cathepsin D: a protease involved in breast cancer metastasis.
Breast Neoplasms
Cathepsin D: an independent prognostic factor for metastasis of breast cancer.
Breast Neoplasms
Cathepsin D: association between TN-stage and steroid receptor status of breast carcinoma.
Breast Neoplasms
Cathepsin D: newly discovered functions of a long-standing aspartic protease in cancer and apoptosis.
Breast Neoplasms
Cathepsin D: Regulation in mammary gland remodeling, misregulation in breast cancer.
Breast Neoplasms
Cathepsin D: screening for new polymorphisms using single-strand conformation polymorphism analysis.
Breast Neoplasms
Cathepsin-D and c-erb-B 2 have an additive prognostic value for breast cancer patients.
Breast Neoplasms
Cathepsin-D expression in breast lesion: an immunohistochemical study.
Breast Neoplasms
Cathepsin-d in breast carcinomas - the role of the stromal cell component.
Breast Neoplasms
Cathepsin-D, urokinase plasminogen activator and type-1 plasminogen activator inhibitor in early breast cancer: an immunohistochemical study of prognostic value and relations to tenascin-C and other factors.
Breast Neoplasms
Cellular and molecular biology of aryl hydrocarbon (Ah) receptor-mediated gene expression.
Breast Neoplasms
Cellular localisation by in situ hybridisation of cathepsin D, stromelysin 3, and urokinase plasminogen activator RNAs in breast cancer.
Breast Neoplasms
Characterization and enumeration of cells secreting tumor markers in the peripheral blood of breast cancer patients.
Breast Neoplasms
Characterization and properties of two monoclonal antibodies specific for the Mr 52,000 precursor of cathepsin D in human breast cancer cells.
Breast Neoplasms
Characterization of purified cathepsin D from malignant human breast tissue.
Breast Neoplasms
Characterization of the estrogen receptor transfected MCF10A breast cell line 139B6.
Breast Neoplasms
Characterization of the proximal estrogen-responsive element of human cathepsin D gene.
Breast Neoplasms
Characterization of very acidic phagosomes in breast cancer cells and their association with invasion.
Breast Neoplasms
Characterizing the Relapse Potential in Different Luminal Subtypes of Breast Cancers with Functional Proteomics.
Breast Neoplasms
Chromatin structure of the regulatory regions of pS2 and cathepsin D genes in hormone-dependent and -independent breast cancer cell lines.
Breast Neoplasms
Clinical and Biological Significance of Cathepsin D Levels in Breast Cancer Cytosol in Women Over 70 years.
Breast Neoplasms
Clinical relevance of biologic factors in male breast cancer.
Breast Neoplasms
Clinical significance of cathepsin D assay in breast cancer tissues.
Breast Neoplasms
Clinical significance of cathepsin D concentration in tumor cytosol of primary breast cancer.
Breast Neoplasms
Clinicopathological study of the expression of hsp27, pS2, cathepsin D and metallothionein in primary invasive breast cancer.
Breast Neoplasms
Cloning and sequencing of the 52K cathepsin D complementary deoxyribonucleic acid of MCF7 breast cancer cells and mapping on chromosome 11.
Breast Neoplasms
Cloning of a major human retinal pigment epithelial lysosomal aspartic protease and mapping its transcriptional start sites.
Breast Neoplasms
Co-chaperone BAG2 Determines the Pro-oncogenic Role of Cathepsin B in Triple-Negative Breast Cancer Cells.
Breast Neoplasms
Co-Expression of Androgen Receptor and Cathepsin D Defines a Triple-Negative Breast Cancer Subgroup with Poorer Overall Survival.
Breast Neoplasms
Co-expression of thymidine kinase and cathepsin D in 200 primary breast carcinomas.
Breast Neoplasms
Comparative biochemical and immunohistochemical studies on the cathepsin D content of human breast cancer.
Breast Neoplasms
Comparative prognostic value of Cathepsin D and urokinase plasminogen activator, detected by immunohistochemistry, in primary breast carcinoma.
Breast Neoplasms
Comparative proteome analysis of breast cancer and adjacent normal breast tissues in human.
Breast Neoplasms
Comparative quantitative immunohistochemical and immunoradiometric determinations of cathepsin D in endometrial adenocarcinoma: predictors of tumor aggressiveness.
Breast Neoplasms
Comparison of Functional Proteomic Analyses of Human Breast Cancer Cell Lines T47D and MCF7.
Breast Neoplasms
Comparison of hyaluronidase expression, invasiveness and tubule formation promotion in ER (-) and ER (+) breast cancer cell lines in vitro.
Breast Neoplasms
Comparison of the tumor associated proteases cathepsin D (CATH D) and urokinase-type plasminogen activator (uPA) in cytosols of human breast cancer patients.
Breast Neoplasms
Confocal fluorescence microscopy of urokinase plasminogen activator receptor and cathepsin D in human MDA-MB-231 breast cancer cells migrating in reconstituted basement membrane.
Breast Neoplasms
Correlated expression of BCL-2 protein, estrogen receptor, cathepsin D and low growth fraction (PCNA) in intracystic papillary breast carcinoma.
Breast Neoplasms
Correlation between cathepsin D expression and p53 protein nuclear accumulation in oesophageal squamous cell carcinoma.
Breast Neoplasms
Correlation between laminin and cathepsin D expressions in breast carcinoma.
Breast Neoplasms
Correlation between mannose-6-phosphate/IGFII receptor and cathepsin D RNA levels by in situ hybridization in benign and malignant mammary tumors.
Breast Neoplasms
Correlation of cytosolic concentrations of ER, PS2, Cath-D, TPS, TK and cAMP in primary breast carcinomas.
Breast Neoplasms
Correlation of tumor cytosol cathepsin D with differentiation and invasiveness of endometrial adenocarcinoma.
Breast Neoplasms
Correlation of two methods for determination of cathepsin D in breast carcinoma (immunohistochemistry and ELISA in cytosol).
Breast Neoplasms
Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.
Breast Neoplasms
Cyclosporin A potentiates estradiol-induced expression of the cathepsin D gene in MCF7 breast cancer cells.
Breast Neoplasms
Cytosol cathepsin D in Thai women with breast cancer.
Breast Neoplasms
Cytosol cathepsin-D content and proliferative activity of human breast cancer. The Comitato Italiano per il Controllo di Qualita del Laboratorio in Oncologia.
Breast Neoplasms
Decreased secretion of Cathepsin D in breast cancer in vivo by tamoxifen: mediated by the mannose-6-phosphate/IGF-II receptor?
Breast Neoplasms
Depletion of Procathepsin D Gene Expression by RNA Interference: A Potential Therapeutic Target for Breast Cancer.
Breast Neoplasms
Design of sensitive fluorogenic substrates for human cathepsin D.
Breast Neoplasms
Development and characterization of a tamoxifen-resistant breast carcinoma xenograft.
Breast Neoplasms
Development of gel staining techniques for detecting the secretion of procathepsin D (52-kDa protein) in MCF-7 human breast cancer cells.
Breast Neoplasms
Differential effect of forms A and B of human progesterone receptor on estradiol-dependent transcription.
Breast Neoplasms
Differential expression of the mannose 6-phosphate/ insulin-like growth factor-II receptor in human breast cancer cell lines of different invasive potential.
Breast Neoplasms
Differential quantitative proteomics reveals key proteins related to phenotypic changes of breast cancer cells expressing progesterone receptor A.
Breast Neoplasms
Differential regulation of cathepsin D by sex steroids in mammary cancer and uterine cells.
Breast Neoplasms
Dissociated overexpression of cathepsin D and estrogen receptor alpha in preinvasive mammary tumors.
Breast Neoplasms
Effect of cathepsin D and prostate specific antigen on latent transforming growth factor-beta in breast cancer cell lines.
Breast Neoplasms
Effect of steroid receptors, pS2 and cathepsin D on the outcome of elderly breast cancer patients: an exploratory investigation.
Breast Neoplasms
Effects of cathepsin D inhibitor from Vicia sativa L. seed hulls on human skin fibroblasts and breast cancer cells (in vitro studies).
Breast Neoplasms
Effects of Cu/Zn superoxide dismutase on estrogen responsiveness and oxidative stress in human breast cancer cells.
Breast Neoplasms
Elevated levels of pro-cathepsin-d in the plasma of breast-cancer patients.
Breast Neoplasms
Endocytosis of pro-cathepsin D into breast cancer cells is mostly independent of mannose-6-phosphate receptors.
Breast Neoplasms
Enhanced Expression of Rab27A Gene by Breast Cancer Cells Promoting Invasiveness and the Metastasis Potential by Secretion of Insulin-Like Growth Factor-II.
Breast Neoplasms
Enzymatically active cathepsin D sensitizes breast carcinoma cells to TRAIL.
Breast Neoplasms
Enzyme-linked immunosorbent assay of HER-2/neu gene product (p185) in breast cancer: its correlation with sex steroid receptors, cathepsin D and histologic grades.
Breast Neoplasms
Enzymes as prognostic markers and therapeutic indicators in patients with cancer.
Breast Neoplasms
Estradiol stimulates cell growth and secretion of procathepsin D and a 120-kilodalton protein in the human ovarian cancer cell line BG-1.
Breast Neoplasms
Estrogen receptor-Sp1 complexes mediate estrogen-induced cathepsin D gene expression in MCF-7 human breast cancer cells.
Breast Neoplasms
Estrogen-regulated cut-off values of pS2 and cathepsin D expression in breast carcinomas.
Breast Neoplasms
Estrogens and growth factors induce the mRNA of the 52K-pro-cathepsin-D secreted by breast cancer cells.
Breast Neoplasms
Evaluation of cathepsin D as a prognostic factor in breast cancer.
Breast Neoplasms
Evaluation of cathepsin D as prognostic predictor in breast cancer.
Breast Neoplasms
Exploration of subsite binding specificity of human cathepsin D through kinetics and rule-based molecular modeling.
Breast Neoplasms
Exposure to xenobiotic compounds: looking for new biomarkers.
Breast Neoplasms
Expression of cathepsin D and galectin 3 in tubular carcinomas of the breast.
Breast Neoplasms
Expression of cathepsin D and pS2 in imprint smears of breast carcinoma.
Breast Neoplasms
Expression of cathepsin D in head and neck cancer.
Breast Neoplasms
Expression of cathepsin D in primary and metastatic human melanoma and dysplastic nevi.
Breast Neoplasms
Expression of cathepsin D, stromelysin-3, and urokinase by reactive stromal cells on breast carcinoma prognosis.
Breast Neoplasms
Expression of E-cadherin, beta-catenin, cathepsin D, gelatinases and their inhibitors in invasive ductal breast carcinomas.
Breast Neoplasms
Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients.
Breast Neoplasms
Expression of ps2 and cathepsin-d in breast-cancer.
Breast Neoplasms
Expression of pS2, c-erbB-2, and cathepsin D during the menstrual cycle in human breast cancers.
Breast Neoplasms
Fibroblasts capture cathepsin D secreted by breast cancer cells: possible role in the regulation of the invasive process.
Breast Neoplasms
Fluctuation of HER2 expression in breast carcinomas during the menstrual cycle.
Breast Neoplasms
Functional and physical interactions between the estrogen receptor Sp1 and nuclear aryl hydrocarbon receptor complexes.
Breast Neoplasms
Heat shock cognate 70 protein secretion as a new growth arrest signal for cancer cells.
Breast Neoplasms
Heterologous expression and characterization of the aspartic endoprotease Pep4um from Ustilago maydis, a homolog of the human Chatepsin D, an important breast cancer therapeutic target.
Breast Neoplasms
High levels of cathepsin B predict poor outcome in patients with breast cancer.
Breast Neoplasms
Hormonal regulation of cathepsin D following transfection of the estrogen or progesterone receptor into three sex steroid hormone resistant cancer cell lines.
Breast Neoplasms
How to target estrogen receptor-negative breast cancer?
Breast Neoplasms
Human breast cancer: prognostic significance of DNA ploidy compared with c-erbB2 expression, Cathepsin D and silver-binding nucleolar organizer regions (AgNORs).
Breast Neoplasms
Human breast milk contains procathepsin D--detection by specific antibodies.
Breast Neoplasms
Hybrid 2D/3D-quantitative structure-activity relationship and modeling studies perspectives of pepstatin A analogs as cathepsin D inhibitors.
Breast Neoplasms
Identification of a functional imperfect estrogen-responsive element in the 5'-promoter region of the human cathepsin D gene.
Breast Neoplasms
Identification of Sulfamoylbenzamide derivatives as selective Cathepsin D inhibitors.
Breast Neoplasms
IGFs and human cancer: implications regarding the risk of growth hormone therapy.
Breast Neoplasms
Immunoelectron microscopy of the receptor for urokinase plasminogen activator and cathepsin D in the human breast cancer cell line MDA-MB-231.
Breast Neoplasms
Immunoenzymatic assay of Mr 52,000 cathepsin D in 182 breast cancer cytosols: low correlation with other prognostic parameters.
Breast Neoplasms
Immunofluorometric analysis of p53 protein and prostate-specific antigen in breast tumours and their association with other prognostic indicators.
Breast Neoplasms
Immunohistochemical analysis of cathepsins D, B, and L in human breast cancer.
Breast Neoplasms
Immunohistochemical detection of cathepsin D in low grade breast invasive cancer.
Breast Neoplasms
Immunohistochemical detection of cathepsin D in T2N0M0 breast carcinoma.
Breast Neoplasms
Immunohistochemical detection of cathepsin-d expression in prostate-cancer.
Breast Neoplasms
Immunohistochemical evaluation of cathepsin D expression in colorectal cancer.
Breast Neoplasms
Immunohistochemical expression of cathepsin D in correlation with extracellular matrix component, steroid receptor status and proliferative indices in breast cancer.
Breast Neoplasms
Immunohistochemical localization of cathepsin D, proliferating cell nuclear antigen and epidermal growth factor receptor in human breast carcinoma analysed by computer image analyser: correlation with histological grade and metastatic behaviour.
Breast Neoplasms
Immunohistochemical localization of metallothionein in human breast cancer in comparison with cathepsin D, stromelysin-1, CD44, extracellular matrix components, P53, Rb, C-erbB-2, EGFR, steroid receptor content and proliferation.
Breast Neoplasms
Immunohistochemical profile of invasive lobular carcinoma of the breast: predominantly vimentin and p53 protein negative, cathepsin D and oestrogen receptor positive.
Breast Neoplasms
Immunohistochemical visualisation of cathepsin-D expression in breast cancer.
Breast Neoplasms
Immunohistologic analysis of invasive phenotype in breast carcinoma. A clinicopathologic study.
Breast Neoplasms
Immunohistologic evaluation of invasion-associated proteases in breast carcinoma.
Breast Neoplasms
Immunoradiometric assay of pro-cathepsin D in breast cancer cytosol: relative prognostic value versus total cathepsin D.
Breast Neoplasms
Immunoradiometric detection of pS2 and total cathepsin D in primary breast cancer biopsies: their correlation with steroid receptors.
Breast Neoplasms
Immunostaining of cathepsin D in breast cancer: quantification by computerised image analysis and correlation with cytosolic assay.
Breast Neoplasms
Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies.
Breast Neoplasms
Impact of steroid receptors, pS2 and cathepsin D on the outcome of N+ postmenopausal breast cancer patients treated with tamoxifen.
Breast Neoplasms
In Vitro and In Vivo Imaging of Peptide-Encapsulated Polymer Nanoparticles for Cancer Biomarker Activated Drug Delivery.
Breast Neoplasms
In vitro degradation of extracellular matrix with Mr 52,000 cathepsin D secreted by breast cancer cells.
Breast Neoplasms
In vivo stimulation by tamoxifen of cathepsin D RNA level in breast cancer.
Breast Neoplasms
Increased cathepsin D level in the serum of patients with metastatic breast carcinoma detected with a specific pro-cathepsin D immunoassay.
Breast Neoplasms
Increased plasma cathepsin D concentration in hepatic carcinoma and cirrhosis but not in breast cancer.
Breast Neoplasms
Increased secretion, altered processing, and glycosylation of pro-cathepsin D in human mammary cancer cells.
Breast Neoplasms
Inhibiting proteasomal proteolysis sustains estrogen receptor-alpha activation.
Breast Neoplasms
Inhibition of breast cancer growth by suramin.
Breast Neoplasms
Insulin-like growth factor II mediates resveratrol stimulatory effect on cathepsin D in breast cancer cells.
Breast Neoplasms
Insulin-like growth factor II modulates the routing of cathepsin D in MCF-7 breast cancer cells.
Breast Neoplasms
Insulin-like growth factors (IGFs) stimulate the release of alpha 1-antichymotrypsin and soluble IGF-II/mannose 6-phosphate receptor from MCF7 breast cancer cells.
Breast Neoplasms
Interaction of the Tumor Metastasis Suppressor Nonmetastatic Protein 23 Homologue H1 and Estrogen Receptor {alpha} Alters Estrogen-Responsive Gene Expression.
Breast Neoplasms
Is the mannose-6-phosphate/insulin-like growth factor 2 receptor coded by a breast cancer suppressor gene?
Breast Neoplasms
Keeping data continuous when analyzing the prognostic impact of a tumor marker: an example with cathepsin D in breast cancer.
Breast Neoplasms
Lack of prognostic value of cathepsin D levels for predicting short term outcomes of breast cancer patients.
Breast Neoplasms
Long-term follow-up confirms prognostic impact of PAI-1 and cathepsin D and L in primary breast cancer.
Breast Neoplasms
Low cathepsin D and low plasminogen activator type 1 inhibitor in tumor cytosols defines a group of node negative breast cancer patients with low risk of recurrence.
Breast Neoplasms
Low levels of basic fibroblast growth factor (bFGF) are associated with a poor prognosis in human breast carcinoma.
Breast Neoplasms
Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis.
Breast Neoplasms
Mass spectrometry (LC-MS/MS) identified proteomic biosignatures of breast cancer in proximal fluid.
Breast Neoplasms
Matrix metalloproteinase expression in human breast cancer: an immunohistochemical study including correlation with cathepsin D, type IV collagen, laminin, fibronectin, EGFR, c-erbB-2 oncoprotein, p53, steroid receptors status and proliferative indices.
Breast Neoplasms
MCF7 mammary cancer cells respond to bFGF and internalize it following its release from extracellular matrix: a permissive role of cathepsin D.
Breast Neoplasms
Mitogenic activity toward human breast cancer cell line MCF-7 of two bFGFs purified from sera of breast cancer patients: co-operative role of cathepsin D.
Breast Neoplasms
Modulation of cathepsin D routing by IGF-II involves IGF-II binding to IGF-II/M6P receptor in MCF-7 breast cancer cells.
Breast Neoplasms
Modulation of the estrogen-regulated proteins cathepsin D and pS2 by opioid agonists in hormone-sensitive breast cancer cell lines (MCF7 and T47D): evidence for an interaction between the two systems.
Breast Neoplasms
Molecular biomarkers for breast cancer prognosis: coexpression of c-erbB-2 and p53.
Breast Neoplasms
Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in MCF-7 cells.
Breast Neoplasms
Multiparametric prognostic evaluation of biological factors in primary breast cancer.
Breast Neoplasms
Multivariable difference gel electrophoresis and mass spectrometry: a case study on transforming growth factor-beta and ERBB2 signaling.
Breast Neoplasms
Mutual predictive value of c-erbB-2 overexpression and various prognostic factors in ductal invasive breast carcinoma.
Breast Neoplasms
New functional aspects of cathepsin D and cathepsin E.
Breast Neoplasms
Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells.
Breast Neoplasms
Oestrogen receptor, progesterone receptor, pS2, ERD5, HSP27 and cathepsin D in invasive ductal breast carcinomas.
Breast Neoplasms
Oestrogen regulates cathepsin D mRNA levels in oestrogen responsive human breast cancer cells.
Breast Neoplasms
Oestrogen- and anti-oestrogen-regulated genes in human breast cancer.
Breast Neoplasms
Overexpression and hormonal regulation of pro-cathepsin D in mammary and endometrial cancer.
Breast Neoplasms
Overexpression of transfected cathepsin D in transformed cells increases their malignant phenotype and metastatic potency.
Breast Neoplasms
Overview on human breast cancer with focus on prognostic and predictive factors with special attention on the tumour suppressor gene p53.
Breast Neoplasms
p53 associated with cathepsin D in primary breast cancer.
Breast Neoplasms
p53, cathepsin D, Bcl-2 are joint prognostic indicators of breast cancer metastatic spreading.
Breast Neoplasms
Pathophysiological functions of cathepsin D: Targeting its catalytic activity versus its protein binding activity?
Breast Neoplasms
Plasminogen activator inhibitor-1 and prognosis in primary breast cancer.
Breast Neoplasms
Potential markers predicting distant metastasis in axillary node-negative breast carcinoma.
Breast Neoplasms
Prediction of axillary lymph node status of breast cancer patients by tumorbiological factors of the primary tumor.
Breast Neoplasms
Pro-cathepsin D interacts with the extracellular domain of the beta chain of LRP1 and promotes LRP1-dependent fibroblast outgrowth.
Breast Neoplasms
Progesterone receptor synthesis in human meningiomas: relation to the estrogen-induced proteins pS2 and cathepsin-D and influence of epidermal growth factor, Forskolin and phorbol ester in vitro.
Breast Neoplasms
Prognostic evaluation of oestrogen-regulated protein immunoreactivity in ductal invasive (NOS) breast cancer.
Breast Neoplasms
Prognostic impact of cathepsin D and c-erbB-2 oncoprotein in a subgroup of node-negative breast cancer patients with low histological grade tumors.
Breast Neoplasms
Prognostic impact of tumor biological factors on survival in node-negative breast cancer.
Breast Neoplasms
Prognostic indicators for early-stage breast-carcinoma .2. Value of cathepsin-d expression, detected by immunocytochemistry - a multiparametric study.
Breast Neoplasms
Prognostic indicators in node-negative early stage breast cancer.
Breast Neoplasms
Prognostic relevance of cathepsin D detection in micrometastatic cells in the bone marrow of patients with primary breast cancer.
Breast Neoplasms
Prognostic relevance of cathepsin D versus oestrogen receptors in node negative breast cancers.
Breast Neoplasms
Prognostic role of high cathepsin D expression in breast cancer: a systematic review and meta-analysis.
Breast Neoplasms
Prognostic significance of immunohistochemical analysis of cathepsin D in low-stage breast cancer.
Breast Neoplasms
Prognostic significance of the estrogen-regulated protein, cathepsin D, in breast cancer. An immunohistochemical study.
Breast Neoplasms
Prognostic significance of the estrogen-regulated proteins, cathepsin-D and pS2, in breast cancer.
Breast Neoplasms
Prognostic significance of tumor-related proteases as a function of the estrogen receptor status.
Breast Neoplasms
Prognostic value of cathepsin D expression and association with histomorphological subtypes in breast cancer.
Breast Neoplasms
Prognostic value of Cathepsin D expression in breast cancer: immunohistochemical assessment and correlation with radiometric assay.
Breast Neoplasms
Prognostic value of cathepsin D in breast cancer.
Breast Neoplasms
Prognostic value of cathepsin D in breast cancer: comparison of immunohistochemical and immunoradiometric detection methods.
Breast Neoplasms
Prognostic value of PS2 and cathepsin D in 710 human primary breast tumors: multivariate analysis.
Breast Neoplasms
Prognostic value of the quantitative measurement of the oncoprotein p185(Her-2/neu) in a group of patients with breast cancer and positive node involvement.
Breast Neoplasms
Prognostic value of total cathepsin D in breast tumors. A possible role in selection of chemoresistant patients.
Breast Neoplasms
Prospective evaluation of prognostic factors in operable breast cancer.
Breast Neoplasms
Protease levels in breast, ovary, and other gynecological tumor tissues: prognostic importance in breast cancer.
Breast Neoplasms
Proteases as prognostic markers in cancer.
Breast Neoplasms
Proteases associated with gynecological tumors.
Breast Neoplasms
Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment.
Breast Neoplasms
Proteolysis of human prolactin: resistance to cathepsin D and formation of a nonangiostatic, C-terminal 16K fragment by thrombin.
Breast Neoplasms
Proteomic analysis of MCF-7 breast cancer cell line exposed to leptin.
Breast Neoplasms
Proteomic characterization of nipple aspirate fluid: identification of potential biomarkers of breast cancer.
Breast Neoplasms
PS2 in breast cancer--alternative or complementary tool to steroid receptor status? Evaluation of 446 cases.
Breast Neoplasms
Quantification and molecular analysis of cathepsin D in breast cyst fluids.
Breast Neoplasms
Quantitative immunohistochemistry using the CAS 200/486 image analysis system in invasive breast carcinoma: a reproducibility study.
Breast Neoplasms
Receiver-operating characteristic (ROC) curve analysis of cathepsin D and pS2 in breast disease; results from a prospective study.
Breast Neoplasms
Reduced levels of cathepsin D associated with tamoxifen resistance and estrogen independence in the ZR-75-1 human breast cancer cell line.
Breast Neoplasms
Reevaluating cathepsin D as a biomarker for breast cancer: serum activity levels versus histopathology.
Breast Neoplasms
Regulation, clinical and biological significance of cathepsin D in breast cancer.
Breast Neoplasms
Relation between cathepsin D expression and other prognostic factors in breast carcinomas.
Breast Neoplasms
Relation of cathepsin D level to the estrogen receptor in human breast cancer.
Breast Neoplasms
Relationship between cathepsin D and other pathological and biological parameters in 1752 patients with primary breast cancer.
Breast Neoplasms
Relationship between cathepsin D, urokinase, and plasminogen activator inhibitors in malignant vs benign breast tumours.
Breast Neoplasms
Relationship between cathepsin-D and other prognostic factors in human breast cancer.
Breast Neoplasms
Relationship between the expression of various markers and prognostic factors in breast cancer.
Breast Neoplasms
Relationships between oestrogen-inducible proteins, oestradiol and electrolyte ratio in breast cyst fluid.
Breast Neoplasms
Release of the aspartyl protease cathepsin D is associated with and facilitates human breast cancer cell invasion.
Breast Neoplasms
Retinoid regulation of human cathepsin D gene expression.
Breast Neoplasms
Reversal of cathepsin D routing modulation in MCF-7 breast cancer cells expressing antisense insulin-like growth factor II (IGF-II).
Breast Neoplasms
Ribozyme-targeting procathepsin D and its effect on invasion and growth of breast cancer cells: an implication in breast cancer therapy.
Breast Neoplasms
Role of direct interaction in BRCA1 inhibition of estrogen receptor activity.
Breast Neoplasms
Salivary duct carcinoma. Part II. Immunohistochemical evaluation of 13 cases for estrogen and progesterone receptors, cathepsin D, and c-erbB-2 protein.
Breast Neoplasms
Significance of estrogen receptors and cathepsin D tissue detection in gastric adenocarcinoma.
Breast Neoplasms
Significance of the tumor protease Cathepsin D for the biology of breast cancer.
Breast Neoplasms
Simultaneous quantitative analyses of c-erbB-2 protein, epidermal growth factor receptor, cathepsin D, and hormone receptors in breast cancer.
Breast Neoplasms
Specific mannose-6-phosphate receptor-independent sorting of pro-cathepsin D in breast cancer cells.
Breast Neoplasms
Specific oncological contribution of cathepsin D and pS2 in human breast cancer: their relationship with TNM status, estradiol receptors, epidermal growth factor receptor and neu amplification.
Breast Neoplasms
Stable transfection of the estrogen receptor cDNA into Hela cells induces estrogen responsiveness of endogenous cathepsin D gene but not of cell growth.
Breast Neoplasms
Stefins and lysosomal cathepsins B, L and D in human breast carcinoma.
Breast Neoplasms
Steroid receptors, pS2 and cathepsin D in early clinically node-negative breast cancer.
Breast Neoplasms
Stromal cell cathepsin D expression and long-term survival in breast cancer.
Breast Neoplasms
Structure, function, regulation and clinical significance of the 52K pro-cathepsin D secreted by breast cancer cells.
Breast Neoplasms
Structure-based subsite specificity mapping of human cathepsin D using statine-based inhibitors.
Breast Neoplasms
Tamoxifen treatment increases the concentration of 52K-cathepsin D and its precursor in breast cancer tissue.
Breast Neoplasms
The immunohistochemical expression of cathepsin D in colorectal cancer.
Breast Neoplasms
The influence of antiestrogens on pS2 and cathepsin D mRNA induction in MCF-7 breast cancer cells.
Breast Neoplasms
The p160 family coactivators regulate breast cancer cell proliferation and invasion through autocrine/paracrine activity of SDF-1alpha/CXCL12.
Breast Neoplasms
The prognostic importance of cathepsin D and E-cadherin in early breast cancer: A single-institution experience.
Breast Neoplasms
The prognostic value of cathepsin D in breast cancer. A long road to the clinic.
Breast Neoplasms
The prognostic-significance of cathepsin-d in breast carcinomas - an immunohistochemical study.
Breast Neoplasms
The propeptide of cathepsin D increases proliferation, invasion and metastasis of breast cancer cells.
Breast Neoplasms
The relative prognostic significance of total cathepsin D and HER-2/neu oncogene amplification in breast cancer. The South Australian Breast Cancer Study Group.
Breast Neoplasms
The role of cathepsin D and PAI-1 in primary invasive breast cancer as prognosticators and predictors of treatment benefit with adjuvant tamoxifen.
Breast Neoplasms
The role of cathepsin D in the invasiveness of human breast cancer cells.
Breast Neoplasms
Three-dimensional chitosan scaffold-based MCF-7 cell culture for the determination of the cytotoxicity of tamoxifen.
Breast Neoplasms
Thrombospondin-1 and -2 in node-negative breast cancer: correlation with angiogenic factors, p53, cathepsin D, hormone receptors and prognosis.
Breast Neoplasms
Time at surgery during menstrual cycle and menopause affects pS2 but not cathepsin D levels in breast cancer.
Breast Neoplasms
Tissue cathepsins as tumor markers.
Breast Neoplasms
Tissue polypeptide antigen in breast cancer cytosol: a new effective prognostic indicator.
Breast Neoplasms
Tocotrienols Modulate Breast Cancer Secretomes and Affect Cancer-Signaling Pathways in MDA-MB-231 Cells: A Label-Free Quantitative Proteomic Analysis.
Breast Neoplasms
Transcriptional activation of cathepsin D gene expression by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition.
Breast Neoplasms
Transcriptional activation of cathepsin D gene expression by growth factors.
Breast Neoplasms
Transfected cathepsin D stimulates high density cancer cell growth by inactivating secreted growth inhibitors.
Breast Neoplasms
Tumor growth fraction, expression of estrogen and progesterone receptors, p53, bcl-2 and cathepsin D activity in primary ductal invasive breast carcinoma and their axillary lymph node metastases.
Breast Neoplasms
Tumour epidermal growth factor receptor, erbB-2 and cathepsin D in node-negative invasive breast cancer: their impact on the selection of patients for systemic adjuvant therapy.
Breast Neoplasms
Tumour-associated fibrinolysis: the prognostic relevance of plasminogen activators uPA and tPA in human breast cancer.
Breast Neoplasms
Two-site immunoenzymometric assay for the 52-kDa cathepsin D in cytosols of breast cancer tissues.
Breast Neoplasms
Upstream stimulatory factors mediate estrogen receptor activation of the cathepsin D promoter.
Breast Neoplasms
Western blotting and enzymatic activity analysis of cathepsin D in breast tissue and sera of patients with breast cancer and benign breast disease and of normal controls.
Breast Neoplasms
Western immunoblotting and enzymatic activity analysis of cathepsin D in human breast cancer cell lines of different invasive potential. Regulation by 17beta-estradiol, tamoxifen and ICI 182,780.
Breast Neoplasms
[Cathepsin D as a prognostic marker in breast cancer]
Breast Neoplasms
[Cathepsin D expression in primary breast cancer. Comparison of immunohistochemical and biochemical results]
Breast Neoplasms
[Cathepsin D in diagnosis of neoplastic diseases]
Breast Neoplasms
[Cathepsin D in primary breast cancer in correlation with various prognostic factors]
Breast Neoplasms
[Cathepsin D: an independent prognostic factor in cancer of the breast]
Breast Neoplasms
[Cytosolic concentrations of cathepsin D in 88 infiltrating ductal breast carcinomas having negative estrogen and progesterone receptors. Correlation with other clinical and biological parameters]
Breast Neoplasms
[Estrogen-induced genes in breast cancer, and their medical importance]
Breast Neoplasms
[Estrogens, cathepsin D and metastasis in cancers of the breast and ovary: invasion or proliferation?]
Breast Neoplasms
[Evaluation of several biological markers in the prognosis of patients with node-negative breast cancer]
Breast Neoplasms
[Expression of cathepsin D in breast cancer and its clinical and histopathological correlations]
Breast Neoplasms
[Mechanism of the overexpression of the cathepsin D gene in breast cancer and consequences in the metastatic process]
Breast Neoplasms
[Molecular markers in breast cancer: practical aspects and morphologic evaluation]
Breast Neoplasms
[New factors of possible prognostic value in breast cancer]
Breast Neoplasms
[Pro-cathepsin D can activate in vitro pro-cathepsin B secreted by ovarian cancers]
Breast Neoplasms
[Prognostic parameters in localized breast cancer]
Breast Neoplasms
[Prognostic value of a continuous variable and an optimal cutoff point]
Breast Neoplasms
[Proteases and prostatic disease: cytosolic cathepsin D]
Breast Neoplasms
[Significance of cathepsin D in breast cancer]
Breast Neoplasms
[Study of G2M cell fraction by flow cytometry in 200 infiltrating ductal breast carcinomas. Correlation with receptor positivity of the epidermal growth factor, cathepsin D and histological grade 3]
Breast Neoplasms
[The expression of Cath-D, c-erbB-2 and EGFR in breast cancer and its correlation to lymphatic metastasis]
Breast Neoplasms
[The prognostic significance of cathepsin D in primary breast cancer]
Breast Neoplasms
[The prognostic value of cathepsin D concentration in cytosol of primary breast carcinoma]
Breast Neoplasms
[The relationship between prognosis, metastasis and microvessel quantity in invasive breast carcinoma]
Breast Neoplasms
[Value of immunohistochemical determination of receptors, tissue proteases, tumor suppressor proteins and proliferation markers as prognostic indicators in primary breast carcinoma]
Breast Neoplasms, Male
Clinical relevance of biologic factors in male breast cancer.
Breast Neoplasms, Male
Expression of cathepsin D and estrogen receptor in male breast carcinoma.
Carcinogenesis
Aspartic proteinases in disease: a structural perspective.
Carcinogenesis
Cathepsin D acts as an essential mediator to promote malignancy of benign prostatic epithelium.
Carcinogenesis
Cathepsin D serum mass concentrations in patients with hepatocellular carcinoma and/or liver cirrhosis.
Carcinogenesis
Co-chaperone BAG2 Determines the Pro-oncogenic Role of Cathepsin B in Triple-Negative Breast Cancer Cells.
Carcinogenesis
Dissociated overexpression of cathepsin D and estrogen receptor alpha in preinvasive mammary tumors.
Carcinogenesis
Growth and differentiation of the normal mammary gland and its tumours.
Carcinogenesis
Induction of cathepsin D protein during estrogen carcinogenesis: possible role in estrogen-mediated kidney tubular cell damage.
Carcinogenesis
Lowering endogenous cathepsin D abundance results in ROS accumulation and cell senescence.
Carcinogenesis
Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells.
Carcinogenesis
Overexpression and hormonal regulation of pro-cathepsin D in mammary and endometrial cancer.
Carcinogenesis
Progestin treatment depresses estrogen receptor but not cathepsin D levels in needle aspirates of benign breast disease.
Carcinogenesis
Proteomic identification of differentially-expressed proteins in esophageal cancer in three ethnic groups in Xinjiang.
Carcinogenesis
Proteomic screening of a cell line model of esophageal carcinogenesis identifies cathepsin D and aldo-keto reductase 1C2 and 1B10 dysregulation in Barrett's esophagus and esophageal adenocarcinoma.
Carcinoma
A xenograft mouse model coupled with in-depth plasma proteome analysis facilitates identification of novel serum biomarkers for human ovarian cancer.
Carcinoma
Activity of cathepsin D and alpha(1)-antitrypsin in the blood serum of patients with mammary carcinoma.
Carcinoma
An immunohistochemical and prognostic evaluation of cathepsin D expression in 105 bladder carcinomas.
Carcinoma
An immunohistochemical assessment of cathepsin D in gastric carcinoma: its impact on clinical prognosis.
Carcinoma
Angiostatin generation by cathepsin D secreted by human prostate carcinoma cells.
Carcinoma
Antimetastatic activity of adriamycin in combinations with proteinase inhibitors in mice.
Carcinoma
Autoantibodies to tumor-associated antigens in epithelial ovarian carcinoma.
Carcinoma
bcl-2 protein in invasive ductal breast carcinomas.
Carcinoma
Carcinoma of the breast arising in microglandular adenosis.
Carcinoma
Cathepsin B and Cathepsin D Expression in Follicular Adenomas and Carcinomas of the Thyroid Gland.
Carcinoma
Cathepsin B and cathepsin D expression in the progression of colorectal adenoma to carcinoma.
Carcinoma
Cathepsin B and D expression in squamous cell carcinoma.
Carcinoma
Cathepsin D activity in human ovarian tissues and ovarian carcinoma.
Carcinoma
Cathepsin D and chromogranin A as predictors of long term disease specific survival after radical prostatectomy for localized carcinoma of the prostate.
Carcinoma
Cathepsin D and dynamic magnetic resonance imaging gadolinium enhancement in malignant and benign breast lesions.
Carcinoma
Cathepsin D and PAI-1 expression in human head and neck cancer.
Carcinoma
Cathepsin D cytosolic assay and immunohistochemical quantification in human prostate tumors.
Carcinoma
Cathepsin D expression in colorectal adenocarcinomas and adenomas.
Carcinoma
Cathepsin D expression in normal, hyperplastic and malignant endometrial tissue: an immunohistochemical analysis.
Carcinoma
Cathepsin D expression in renal cell cancer-clinical implications.
Carcinoma
Cathepsin D immunoreactivity in ovarian cancer: correlation with prognostic factors.
Carcinoma
Cathepsin D in laryngeal carcinoma. preliminary report.
Carcinoma
Cathepsin D in normal and neoplastic thyroid tissues.
Carcinoma
Cathepsin D in tissue and serum of patients with squamous cell carcinoma of the head and neck.
Carcinoma
Cathepsin D is secreted from M-BE cells: its potential role as a biomarker of lung cancer.
Carcinoma
Cathepsin D serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging.
Carcinoma
Cathepsin D serum levels are not a valid serum marker in renal cell carcinoma.
Carcinoma
Cathepsin expression in oral squamous cell carcinoma: relationship with clinicopathologic factors.
Carcinoma
Cathepsin-D, urokinase plasminogen activator and type-1 plasminogen activator inhibitor in early breast cancer: an immunohistochemical study of prognostic value and relations to tenascin-C and other factors.
Carcinoma
CD44 expression in colorectal cancer. An immunohistochemical study including correlation with cathepsin D immunoreactivity and some tumour clinicopathological features.
Carcinoma
Clinical significance of cathepsin D in primary ovarian cancer.
Carcinoma
Clinicopathological significance of cathepsin D expression in gastric adenocarcinoma.
Carcinoma
Combination of new biologic parameters as a prognostic index in epithelial ovarian carcinoma.
Carcinoma
Comparison of cathepsin D determinations in human carcinomas by enzyme immunoassay and immunoradiometric assay.
Carcinoma
Correlation between cathepsin D expression and p53 protein nuclear accumulation in oesophageal squamous cell carcinoma.
Carcinoma
Correlation between laminin and cathepsin D expressions in breast carcinoma.
Carcinoma
Correlation of mammographic appearance and molecular prognostic factors in high-grade breast carcinomas.
Carcinoma
Correlation of tumor cytosol cathepsin D with differentiation and invasiveness of endometrial adenocarcinoma.
Carcinoma
CORRELATIONSHIP OF CATHEPSIN D AND TOPOISOMERASE II ALPHA WITH NUCLEAR GRADING IN BREAST CANCERS.
Carcinoma
Corrigendum: Overexpression Cathepsin D Contributes to Perineural Invasion of Salivary Adenoid Cystic Carcinoma.
Carcinoma
Detection of oral squamous cell carcinoma metastasis with cathepsin D: An immunohistochemical approach.
Carcinoma
Differential expression levels of urokinase-type plasminogen activator and cathepsin D in locally advanced laryngeal squamous cell carcinoma: clinical implications.
Carcinoma
Dissociated overexpression of cathepsin D and estrogen receptor alpha in preinvasive mammary tumors.
Carcinoma
Drug resistant tumor cells have increased levels of tumor markers for invasion and metastasis.
Carcinoma
Effect of Temperature and pH on the Secondary Structure and Denaturation Process of Jumbo Squid Hepatopancreas Cathepsin D.
Carcinoma
Effect of tumor size on the association between ps2 and cathepsin-d in primary breast-cancer.
Carcinoma
Endogenous cathepsin D-mediated hydrolysis of insulin-like growth factor-binding proteins in cultured human prostatic carcinoma cells.
Carcinoma
Enzyme-linked immunosorbent assay of HER-2/neu gene product (p185) in breast cancer: its correlation with sex steroid receptors, cathepsin D and histologic grades.
Carcinoma
Estrogen receptors and cathepsin D in human thyroid tissue.
Carcinoma
Evaluation of cathepsin D and epidermal growth factor receptor in prostate carcinoma.
Carcinoma
Evaluation of the prognostic significance of cathepsin D, epidermal growth factor receptor, and c-erbB-2 in early cervical squamous cell carcinoma. An immunohistochemical study.
Carcinoma
Evaluation of the prognostic significance of nm23/NDP kinase and cathepsin D in anal carcinomas. An immunohistochemical study.
Carcinoma
Expression and posttranslational fate of cathepsin D in HT-29 tumor cells depend on their enterocytic differentiation state.
Carcinoma
Expression of cathepsin D and B in invasion and metastasis of squamous cell carcinoma.
Carcinoma
Expression of cathepsin D in bladder carcinoma: correlation with pathological features and serum cystatin C levels.
Carcinoma
Expression of cathepsin D in malignant and in the corresponding non-malignant node-negative laryngeal samples: correlation with receptors for androgen, glucocorticoid, oestrogen and progesterone.
Carcinoma
Expression of cathepsin D in transitional cell bladder tumours.
Carcinoma
Expression of cathepsin D in urothelial carcinoma of the urinary bladder: an immunohistochemical study including correlations with extracellular matrix components, CD44, p53, Rb, c-erbB-2 and the proliferation indices.
Carcinoma
Expression of cathepsins B, D and K in thymic epithelial tumours.
Carcinoma
Expression of oestrogen and progesterone receptors, Ki-67, p53 and BCL-2 proteins, cathepsin D, urokinase plasminogen activator and urokinase plasminogen activator-receptors in carcinomas of the female breast in an African population.
Carcinoma
Expression profiling of supraglottic carcinoma: PTEN and thrombospondin 2 are associated with inhibition of lymphatic metastasis.
Carcinoma
Expression, localization, and thyrotropin regulation of cathepsin D in human thyroid tissues.
Carcinoma
Gastric carcinoma: expression of c-erbB-2/neu oncoprotein, epidermal growth factor receptor, cathepsin D, progesterone receptor and tumor associated glycoprotein-72 in different histological types.
Carcinoma
Glycoprotein CD44 expression in colorectal neoplasms. An immuno-histochemical study including correlation with cathepsin D, extracellular matrix components, p53, Rb, bcl-2, c-erbB-2, EGFR and proliferation indices.
Carcinoma
Immuno-histochemical evaluation of Cathepsin D in malignant salivary gland carcinomas.
Carcinoma
Immunocytochemical localization of Cathepsin D and CA 125 in ovarian cancer.
Carcinoma
Immunohistochemical analysis and prognostic value of cathepsin D determination in laryngeal squamous cell carcinoma.
Carcinoma
Immunohistochemical analysis of cathepsin D in prostate carcinoma.
Carcinoma
Immunohistochemical evaluation of tissue-specific proteolytic enzymes in adenomas containing foci of early carcinoma: correlations with cathepsin D expression and other malignant features.
Carcinoma
Immunohistochemical expression of cathepsin D in laryngeal epithelial lesions: correlation with CD44 expression, p53 and Rb status and proliferation associated indices.
Carcinoma
Immunohistochemical Expression of Cathepsin D in Primary and Recurrent Squamous Cell Carcinoma.
Carcinoma
Immunohistochemical markers of prolonged survival in small cell carcinoma of the lung. An immunohistochemical study.
Carcinoma
Immunohistochemical studies of proliferating cell nuclear antigen and cathepsin D in transitional cell carcinoma of the urinary bladder.
Carcinoma
Immunolocalisation of aspartic proteinases in the developing human stomach.
Carcinoma
Immunolocalization of cathepsin D in normal and neoplastic human tissues.
Carcinoma
In vitro activation of pro-cathepsin B by three serine proteinases: leucocyte elastase, cathepsin G, and the urokinase-type plasminogen activator.
Carcinoma
Inactivation of cathepsin D from human gastric mucosa and from stomach carcinoma by diazoacetyl-DL-norleucine methyl ester.
Carcinoma
Increased plasma cathepsin D concentration in hepatic carcinoma and cirrhosis but not in breast cancer.
Carcinoma
Intracytoplasmic localization of cathepsin D reflects the invasive potential of gastric carcinoma.
Carcinoma
MIB1 proliferation index in breast infiltrating carcinoma: comparison with other proliferative markers and association with new biological prognostic factors.
Carcinoma
New functional aspects of cathepsin D and cathepsin E.
Carcinoma
Nm23 and cathepsin D expression in laryngeal carcinomas.
Carcinoma
Overexpression Cathepsin D Contributes to Perineural Invasion of Salivary Adenoid Cystic Carcinoma.
Carcinoma
Pathological and biological features of mammographically detected invasive breast carcinomas.
Carcinoma
Pre-operative urinary cathepsin D is associated with survival in patients with renal cell carcinoma.
Carcinoma
Prognostic significance of angiogenesis and immunoreactivity of cathepsin D and type IV collagen in high-grade stage T1 primary bladder cancer.
Carcinoma
Prognostic significance of the metastasis-inducing protein S100A4 (p9Ka) in human breast cancer.
Carcinoma
Prognostic value of cytosolyc cathepsin D content in resectable gastric cancer.
Carcinoma
Prognostic value of p53 expression in early-stage breast-carcinoma compared with tumor angiogenesis, epidermal growth-factor receptor, C-erbb-2, cathepsin-d, DNA-ploidy, parameters of cell-kinetics and conventional features.
Carcinoma
Proliferation Markers and EGF in ACTH-Secreting Adenomas and Carcinomas of the Pituitary.
Carcinoma
Protease levels in breast, ovary, and other gynecological tumor tissues: prognostic importance in breast cancer.
Carcinoma
Proteases associated with gynecological tumors.
Carcinoma
Quantitative immunohistochemical determination of cathepsin D levels in prostatic carcinoma biopsies. Correlation with tumor grade, stage, PSA level, and DNA ploidy status.
Carcinoma
Regulation of cathepsin D dependent on the phenotype of colon carcinoma cells.
Carcinoma
Relationship of tumoral hyaluronic acid and cathepsin D contents with histological type of gastric carcinoma.
Carcinoma
Salivary duct carcinoma. Part II. Immunohistochemical evaluation of 13 cases for estrogen and progesterone receptors, cathepsin D, and c-erbB-2 protein.
Carcinoma
Significance of estrogen receptors and cathepsin D tissue detection in gastric adenocarcinoma.
Carcinoma
Significance of the tumor protease Cathepsin D for the biology of breast cancer.
Carcinoma
Steroid receptors, pS2 and cathepsin D in early clinically node-negative breast cancer.
Carcinoma
Studies of the activities of lysosomal enzymes in serum and buccal pouch tissue of hamsters during 7,12-dimethylbenz[a]anthracene-induced carcinogenesis.
Carcinoma
Tenascin C and cathepsin d expression in adipocytic tumors: an immunohistochemical investigation of 43 cases.
Carcinoma
The diagnostic value of lysosomal enzyme patterns in bronchial aspirates of patients with suspected bronchial carcinoma.
Carcinoma
The effect of combined therapy on activity of cathepsin D and alpha-1-antitrypsin in the blood serum of women with cervical cancer.
Carcinoma
The pathology of low-grade adenosquamous carcinoma of the breast. An immunohistochemical study.
Carcinoma
The potential prognostic value of cathepsin D protein in serous ovarian cancer.
Carcinoma
The prognostic value of the expression of collagenase IV, cathepsin D and metallothionein in squamous cell carcinomas of the skin determined by immunohistochemistry.
Carcinoma
The state of differentiation of HT-29 colon carcinoma cells alters the secretion of cathepsin D and of plasminogen activator.
Carcinoma
The value of the lysosomal protease cathepsin-d in egyptian bladder-cancer.
Carcinoma
Urokinase-type plasminogen activator, plasminogen activator inhibitor type 1 and cathepsin D: analysis of their prognostic significance in squamous cell carcinoma of the head and neck.
Carcinoma
[A comparism between lysosomal enzyme activity in normal ectocervical squamous epithelium and squamous carcinoma of the ectocervix]
Carcinoma
[Axillary lymph node involvement in hormone-independent breast carcinomas]
Carcinoma
[Cathepsin D activity in human ovarian carcinoma]
Carcinoma
[CYFRA 21.1 cytosol levels in lung adenocarcinomas. Correlation with other clinico-biological parameters]
Carcinoma
[Cytosolic cathepsin D levels in squamous carcinomas of the lung]
Carcinoma
[Expression of Cath-D, P-gp and Her-2 in carcinoma of the cardia]
Carcinoma
[Immunohistochemical study of Cath-D and CD44 in laryngeal squamous cell carcinomas]
Carcinoma
[Study of the cytosolic concentrations of the tissue poly-peptide specific (TPS) antigen in infiltrating ductal carcinomas of the breast. Positive relationship with hormone dependency and negative with cellular proliferation]
Carcinoma
[The function of lymphangiogenesis and the expression of Cathepsin D in laryngeal carcinoma metabasis].
Carcinoma, Adenoid Cystic
Corrigendum: Overexpression Cathepsin D Contributes to Perineural Invasion of Salivary Adenoid Cystic Carcinoma.
Carcinoma, Adenoid Cystic
Immuno-histochemical evaluation of Cathepsin D in malignant salivary gland carcinomas.
Carcinoma, Adenoid Cystic
Overexpression Cathepsin D Contributes to Perineural Invasion of Salivary Adenoid Cystic Carcinoma.
Carcinoma, Ductal
Analysis of cathepsin D in human breast cancer: usefulness of the processed 31 kDa active form of the enzyme as a prognostic indicator in node-negative and node-positive patients.
Carcinoma, Ductal
Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study.
Carcinoma, Ductal
Cathepsin D in host stromal cells, but not in tumor cells, is associated with aggressive behavior in node-negative breast cancer.
Carcinoma, Ductal
Clinical and Biological Significance of Cathepsin D Levels in Breast Cancer Cytosol in Women Over 70 years.
Carcinoma, Ductal
Correlation between laminin and cathepsin D expressions in breast carcinoma.
Carcinoma, Ductal
Effect of tumor size on the association between ps2 and cathepsin-d in primary breast-cancer.
Carcinoma, Ductal
Enzyme-linked immunosorbent assay of HER-2/neu gene product (p185) in breast cancer: its correlation with sex steroid receptors, cathepsin D and histologic grades.
Carcinoma, Ductal
Expression of cathepsin D and galectin 3 in tubular carcinomas of the breast.
Carcinoma, Ductal
Histological grade in breast cancer: association with clinical and biological features in a series of 229 patients.
Carcinoma, Ductal
Immunohistochemical expression of uPA, PAI-1, cathepsin D and apoptotic cells in ductal carcinoma in situ of the breast.
Carcinoma, Ductal
Prognostic significance of immunohistochemical analysis of cathepsin D in low-stage breast cancer.
Carcinoma, Ductal
Prognostic value of cathepsin D expression and association with histomorphological subtypes in breast cancer.
Carcinoma, Ductal
Reduced clinicopathological influence of hormone-dependence on breast carcinomas in women older than 70 years.
Carcinoma, Ductal
Significance of the tumor protease Cathepsin D for the biology of breast cancer.
Carcinoma, Endometrioid
Clinical prognostic factors and expression of cathepsin D in endometrioid adenocarcinoma.
Carcinoma, Hepatocellular
Altered intracellular processing and enhanced secretion of procathepsin D in a highly deviated rat hepatoma.
Carcinoma, Hepatocellular
Antimalarial evaluation of copper(II) nanohybrid solids: inhibition of plasmepsin II, a hemoglobin-degrading malarial aspartic protease from Plasmodium falciparum.
Carcinoma, Hepatocellular
Cathepsin D associates with lysosomal membranous protein.
Carcinoma, Hepatocellular
Cathepsin D serum mass concentrations in patients with hepatocellular carcinoma and/or liver cirrhosis.
Carcinoma, Hepatocellular
Cloning and sequence analysis of cDNA for human cathepsin D.
Carcinoma, Hepatocellular
DNA and protein content as cellular biochemical parameters. A discussion with two examples: acid phosphatase and cathepsin D in rat liver and hepatoma and acid phosphatase in human breast normal tissue and adenocarcinoma.
Carcinoma, Hepatocellular
Elevated activity and increased mannose-6-phosphate in the carbohydrate moiety of cathepsin D from human hepatoma.
Carcinoma, Hepatocellular
Elevated carbohydrate phosphotransferase activity in human hepatoma and phosphorylation of cathepsin D.
Carcinoma, Hepatocellular
Excision of foreign gene product with cathepsin D in chicken hepatoma cell line.
Carcinoma, Hepatocellular
Expressions of chromogranin A and cathepsin D in human primary hepatocellular carcinoma.
Carcinoma, Hepatocellular
Increased plasma cathepsin D concentration in hepatic carcinoma and cirrhosis but not in breast cancer.
Carcinoma, Hepatocellular
Influence of Ukrain and cyclophosphamide administration on HA-1 murine hepatoma and LS lymphoma on aspartic proteinase cathepsin D.
Carcinoma, Hepatocellular
Mannose 6-phosphate-independent targeting of cathepsin D to lysosomes in HepG2 cells.
Carcinoma, Hepatocellular
Proteolytic activation of internalized cholera toxin within hepatic endosomes by cathepsin D.
Carcinoma, Hepatocellular
Proteomic analysis of differential protein expression in a human hepatoma revertant cell line by using an improved two-dimensional electrophoresis procedure combined with matrix assisted laser desorption/ionization-time of flight-mass spectrometry.
Carcinoma, Hepatocellular
Purification and properties of cathepsin D from rat Yoshida ascites hepatoma AH-130.
Carcinoma, Hepatocellular
Small guanosine triphosphatase Rho/Rho-associated kinase as a novel regulator of intracellular redistribution of lysosomes in invasive tumor cells.
Carcinoma, Hepatocellular
Sphingomyelins suppress the targeted disruption of lysosomes/endosomes by the photosensitizer NPe6 during photodynamic therapy.
Carcinoma, Hepatocellular
[Carbohydrate phosphotransferase in human hepatoma and phosphorylation of cathepsin D]
Carcinoma, Hepatocellular
[Cysteine proteinases and their inhibitors in the development of mouse HA-1 hepatoma and antineoplastic therapy]
Carcinoma, Hepatocellular
[Tumor-associated impairment of the processing of hepatoma cathepsin D]
Carcinoma, Intraductal, Noninfiltrating
Analysis of cathepsin D in human breast cancer: usefulness of the processed 31 kDa active form of the enzyme as a prognostic indicator in node-negative and node-positive patients.
Carcinoma, Intraductal, Noninfiltrating
Dissociated overexpression of cathepsin D and estrogen receptor alpha in preinvasive mammary tumors.
Carcinoma, Intraductal, Noninfiltrating
Immunohistochemical expression of uPA, PAI-1, cathepsin D and apoptotic cells in ductal carcinoma in situ of the breast.
Carcinoma, Lewis Lung
Antimetastatic activity of adriamycin in combinations with proteinase inhibitors in mice.
Carcinoma, Lobular
Immunohistochemical profile of invasive lobular carcinoma of the breast: predominantly vimentin and p53 protein negative, cathepsin D and oestrogen receptor positive.
Carcinoma, Lobular
Significance of the tumor protease Cathepsin D for the biology of breast cancer.
Carcinoma, Medullary
Immunohistochemical detection of nm23/NDP kinase and cathepsin D in medullary carcinomas of the thyroid gland.
Carcinoma, Mucoepidermoid
Immuno-histochemical evaluation of Cathepsin D in malignant salivary gland carcinomas.
Carcinoma, Non-Small-Cell Lung
Clinicopathological significance of cathepsin D expression in non-small cell lung cancer is conditional on apoptosis-associated protein phenotype: an immunohistochemistry study.
Carcinoma, Non-Small-Cell Lung
Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Immunostaining of cathepsin-d in nonsmall cell lung-cancer - correlations with morphological and biological parameters.
Carcinoma, Non-Small-Cell Lung
Secretion of a latent, acid activatable cathepsin L precursor by human non-small cell lung cancer cell lines.
Carcinoma, Non-Small-Cell Lung
[Expression and prognostic relation of cathepsin D in non-small cell lung cancer tissues and lymph nodes]
Carcinoma, Ovarian Epithelial
Autoantibodies to tumor-associated antigens in epithelial ovarian carcinoma.
Carcinoma, Ovarian Epithelial
Combination of new biologic parameters as a prognostic index in epithelial ovarian carcinoma.
Carcinoma, Ovarian Epithelial
The Potential Role of the Proteases Cathepsin D and Cathepsin L in the Progression and Metastasis of Epithelial Ovarian Cancer.
Carcinoma, Papillary
Expression, localization, and thyrotropin regulation of cathepsin D in human thyroid tissues.
Carcinoma, Renal Cell
Cathepsin D expression in renal cell cancer-clinical implications.
Carcinoma, Renal Cell
Cathepsin D serum levels are not a valid serum marker in renal cell carcinoma.
Carcinoma, Renal Cell
Pre-operative urinary cathepsin D is associated with survival in patients with renal cell carcinoma.
Carcinoma, Small Cell
Immunohistochemical markers of prolonged survival in small cell carcinoma of the lung. An immunohistochemical study.
Carcinoma, Squamous Cell
Cathepsin B and D expression in squamous cell carcinoma.
Carcinoma, Squamous Cell
Cathepsin D and PAI-1 expression in human head and neck cancer.
Carcinoma, Squamous Cell
Cathepsin D in tissue and serum of patients with squamous cell carcinoma of the head and neck.
Carcinoma, Squamous Cell
Cathepsin D is secreted from M-BE cells: its potential role as a biomarker of lung cancer.
Carcinoma, Squamous Cell
Evaluation of the prognostic significance of cathepsin D, epidermal growth factor receptor, and c-erbB-2 in early cervical squamous cell carcinoma. An immunohistochemical study.
Carcinoma, Squamous Cell
Evaluation of the prognostic significance of nm23/NDP kinase and cathepsin D in anal carcinomas. An immunohistochemical study.
Carcinoma, Squamous Cell
Expression of cathepsin D and B in invasion and metastasis of squamous cell carcinoma.
Carcinoma, Squamous Cell
Expression of cathepsins B, D and K in thymic epithelial tumours.
Carcinoma, Squamous Cell
Immunohistochemical expression of cathepsin D in laryngeal epithelial lesions: correlation with CD44 expression, p53 and Rb status and proliferation associated indices.
Carcinoma, Squamous Cell
Immunohistochemical Expression of Cathepsin D in Primary and Recurrent Squamous Cell Carcinoma.
Carcinoma, Squamous Cell
The prognostic value of the expression of collagenase IV, cathepsin D and metallothionein in squamous cell carcinomas of the skin determined by immunohistochemistry.
Carcinoma, Squamous Cell
Urokinase-type plasminogen activator, plasminogen activator inhibitor type 1 and cathepsin D: analysis of their prognostic significance in squamous cell carcinoma of the head and neck.
Carcinoma, Squamous Cell
[Cytosolic cathepsin D levels in squamous carcinomas of the lung]
Carcinoma, Squamous Cell
[Immunohistochemical study of Cath-D and CD44 in laryngeal squamous cell carcinomas]
Carcinoma, Transitional Cell
Cathepsin D serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging.
Carcinoma, Transitional Cell
Immunohistochemical studies of proliferating cell nuclear antigen and cathepsin D in transitional cell carcinoma of the urinary bladder.
Carcinoma, Transitional Cell
Prognostic significance of angiogenesis and immunoreactivity of cathepsin D and type IV collagen in high-grade stage T1 primary bladder cancer.
Cardiac Tamponade
Pericardial tamponade-induced myocardial ischemic injury.
Cardiomegaly
Increased myocardial cathepsin D activity during regression of thyrotoxic cardiac hypertrophy.
Cardiomegaly
The pathways of protein synthesis and degradation in normal heart and during development and regression of cardiac hypertrophy.
Cardiomyopathies
Biomarkers and Their Relation to Cardiac Function Late After Peripartum Cardiomyopathy.
Cardiomyopathies
Inhibition of the Notch1 pathway induces peripartum cardiomyopathy.
Cardiomyopathies
Is there cardiac risk in panic disorder? An updated systematic review.
Cardiomyopathy, Dilated
Autophagic degeneration and death of cardiomyocytes in heart failure.
Cardiotoxicity
Lysosomal alterations in heart and liver of mice treated with doxorubicin.
Cardiovascular Diseases
High levels of cathepsin D and cystatin B are associated with increased risk of coronary events.
Cardiovascular Diseases
Increased Cathepsin D Correlates with Clinical Parameters in Newly Diagnosed Type 2 Diabetes.
Cardiovascular Diseases
Relation between serum cathepsin D levels and endothelial dysfunction in patients with chronic kidney disease.
Cardiovascular Diseases
[Analysis of Urine Proteome in Patients With Postinfarction Cardiosclerosis Combined With Hypertensive Disease for Assessing Endothelial Dysfunction].
Cataract
Link between neurodegeneration and trabecular meshwork injury in glaucomatous patients.
Cataract
TDRD7 participates in lens development and spermiogenesis by mediating autophagosome maturation.
cathepsin d deficiency
Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation.
cathepsin d deficiency
Cathepsin D deficiency and NCL/Batten disease: there's more to death than apoptosis.
cathepsin d deficiency
Cathepsin D Deficiency and NCL/Batten Disease: There's More to Death than Apoptosis.
cathepsin d deficiency
Cathepsin D deficiency causes juvenile-onset ataxia and distinctive muscle pathology.
cathepsin d deficiency
Cathepsin D deficiency delays central nervous system myelination by inhibiting proteolipid protein trafficking from late endosome/lysosome to plasma membrane.
cathepsin d deficiency
Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling.
cathepsin d deficiency
Cathepsin D deficiency induces cytoskeletal changes and affects cell migration pathways in the brain.
cathepsin d deficiency
Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons.
cathepsin d deficiency
Cathepsin D deficiency induces oxidative damage in brain pericytes and impairs the blood-brain barrier.
cathepsin d deficiency
Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis.
cathepsin d deficiency
Cathepsin D deficiency is associated with a human neurodegenerative disorder.
cathepsin d deficiency
Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis.
cathepsin d deficiency
Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo.
cathepsin d deficiency
Congenital ovine neuronal ceroid lipofuscinosis--a cathepsin D deficiency with increased levels of the inactive enzyme.
cathepsin d deficiency
Genetic modifiers of degeneration in the cathepsin D deficient Drosophila model for neuronal ceroid lipofuscinosis.
cathepsin d deficiency
Haematopoietic development and immunological function in the absence of cathepsin D.
cathepsin d deficiency
Metabolic epilepsies: approaches to a diagnostic challenge.
cathepsin d deficiency
Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression.
cathepsin d deficiency
Murine cathepsin D deficiency is associated with dysmyelination/myelin disruption and accumulation of cholesteryl esters in the brain.
cathepsin d deficiency
Novel mutation and the first prenatal screening of cathepsin D deficiency (CLN10).
cathepsin d deficiency
Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway.
cathepsin d deficiency
Rapid and Progressive Loss of Multiple Retinal Cell Types in Cathepsin D-Deficient Mice-An Animal Model of CLN10 Disease.
cathepsin d deficiency
Single point mutation in Rabenosyn-5 in a female with intractable seizures and evidence of defective endocytotic trafficking.
cathepsin d deficiency
Synaptic changes in the thalamocortical system of cathepsin D-deficient mice: a model of human congenital neuronal ceroid-lipofuscinosis.
cathepsin l deficiency
Epidermal differentiation: the role of proteases and their inhibitors.
Central Nervous System Neoplasms
Immunolocalization of cathepsin D in the human central nervous system and central nervous system neoplasms.
Cerebellar Diseases
Cerebellar dysfunction in a family harboring the PSEN1 mutation co-segregating with a Cathepsin D variant p.A58V.
Cerebral Amyloid Angiopathy, Familial
A beta-amyloid peptide variant related with familial Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis is poorly eliminated by cathepsin D.
Cerebral Amyloid Angiopathy, Familial
Hereditary cerebral hemorrhage with amyloidosis (Dutch): a model for congophilic plaque formation without neurofibrillary pathology.
Cerebral Hemorrhage
A beta-amyloid peptide variant related with familial Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis is poorly eliminated by cathepsin D.
Cerebral Hemorrhage
Hereditary cerebral hemorrhage with amyloidosis (Dutch): a model for congophilic plaque formation without neurofibrillary pathology.
Chemical and Drug Induced Liver Injury
[Structuro-functional changes in dog liver and regional lymph node lysosomes in toxic hepatitis]
Cholera
Comparative responsiveness of HL-60, HL-60R, and HL-60R+ (LRARSN) cells to retinoic acid, calcitriol, 9 cis-retinoic acid, and sodium butyrate.
Cholera
Proteolytic activation of internalized cholera toxin within hepatic endosomes by cathepsin D.
Cholera
Role of receptor-mediated endocytosis, endosomal acidification and cathepsin D in cholera toxin cytotoxicity.
Cholesteatoma
Gene expression analysis of human middle ear cholesteatoma using complementary DNA arrays.
Cholesteatoma
Immunohistochemical investigations of cathepsin D activity in the structures of cholesteatoma.
Chondrosarcoma
Implication of granulocyte-macrophage colony-stimulating factor induced neutrophil gelatinase-associated lipocalin in pathogenesis of rheumatoid arthritis revealed by proteome analysis.
Chondrosarcoma
[Indices of proteolysis in evaluation of resorption in bone tumors]
Choroid Plexus Neoplasms
Immunolocalization of cathepsin D in the human central nervous system and central nervous system neoplasms.
Chronic Periodontitis
Amplified crevicular leukocyte activity in aggressive periodontal disease.
Colitis
Cathepsin D is up-regulated in inflammatory bowel disease macrophages.
Colitis
Sphingomyelin and phosphatidylcholine contrarily affect the induction of apoptosis in intestinal epithelial cells.
Colonic Diseases
Expression of hormone receptors, cathepsin D, and HER-2/neu oncoprotein in normal colon and colonic disease.
Colonic Neoplasms
Cathepsin D and carcino-embryonic antigen in serum, urine and tissues of colon adenocarcinoma patients.
Colonic Neoplasms
Cigarette smoke extracts induced the colon cancer migration via regulating epithelial mesenchymal transition and metastatic genes in human colon cancer cells.
Colonic Neoplasms
Comprehensive proteome analysis of an Apc mouse model uncovers proteins associated with intestinal tumorigenesis.
Colonic Neoplasms
Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells.
Colonic Neoplasms
Increased expression of cathepsin D is required for L1-mediated colon cancer progression.
Colonic Neoplasms
Lysosomal exoglycosidases and cathepsin D in colon adenocarcinoma.
Colonic Neoplasms
New cathepsin d inhibitors with hydroxyethylamine isosteres: preparation and characterization.
Colonic Neoplasms
[Activity of cathepsin D in some neoplasms of the gastrointestinal tract]
Colorectal Neoplasms
Acetate-induced apoptosis in colorectal carcinoma cells involves lysosomal membrane permeabilization and cathepsin D release.
Colorectal Neoplasms
Activation of cathepsin B, secreted by a colorectal cancer cell line requires low pH and is mediated by cathepsin D.
Colorectal Neoplasms
Activity of cathepsin B and D in colorectal cancer: relationships with tumour budding.
Colorectal Neoplasms
Cancer with low cathepsin D levels is susceptible to V-ATPase inhibition.
Colorectal Neoplasms
Cathepsin D activity in colorectal cancer.
Colorectal Neoplasms
Cathepsin D content in colorectal cancer. Correlation with cathepsin D activity and other biological parameters: a preliminary report.
Colorectal Neoplasms
Cathepsin D cytosol content in colorectal cancer.
Colorectal Neoplasms
Cathepsin D expression as a possible predictor of lymph node metastasis in submucosal colorectal cancer.
Colorectal Neoplasms
Cathepsin D expression in colorectal adenocarcinomas and adenomas.
Colorectal Neoplasms
Cathepsin D Expression in Colorectal Cancer: From Proteomic Discovery through Validation Using Western Blotting, Immunohistochemistry, and Tissue Microarrays.
Colorectal Neoplasms
Cathepsin D expression in human colorectal cancer: relationship with tumour type and tissue differentiation grade.
Colorectal Neoplasms
Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagy-independent degradation of damaged mitochondria.
Colorectal Neoplasms
Cathepsin D protein levels in colorectal tumors: divergent expression patterns suggest complex regulation and function.
Colorectal Neoplasms
Cathepsin-d activity levels in colorectal-cancer - correlation with cathepsin-B and cathepsin-L and other biological and clinical-parameters.
Colorectal Neoplasms
CD44 expression in colorectal cancer. An immunohistochemical study including correlation with cathepsin D immunoreactivity and some tumour clinicopathological features.
Colorectal Neoplasms
Direct-S: a directed mass spectrometry method for biomarker verification in native serum.
Colorectal Neoplasms
Evaluation of serum cathepsin B and D in relation to clinicopathological staging of colorectal cancer.
Colorectal Neoplasms
Glycoprotein CD44 expression in colorectal neoplasms. An immuno-histochemical study including correlation with cathepsin D, extracellular matrix components, p53, Rb, bcl-2, c-erbB-2, EGFR and proliferation indices.
Colorectal Neoplasms
Hyperplex-MRM: A Hybrid Multiple Reaction Monitoring Method Using mTRAQ/iTRAQ Labeling for Multiplex Absolute Quantification of Human Colorectal Cancer Biomarker.
Colorectal Neoplasms
Immunohistochemical analysis and prognostic value of cathepsin D determination in laryngeal squamous cell carcinoma.
Colorectal Neoplasms
Immunohistochemical evaluation of cathepsin D expression in colorectal cancer.
Colorectal Neoplasms
Immunohistochemical evaluation of cathepsin D expression in colorectal tumours: a correlation with extracellular matrix components, p53, pRb, bcl-2, c-erbB-2, EGFR and proliferation indices.
Colorectal Neoplasms
Immunohistochemical localization of cathepsin D in colorectal tumors.
Colorectal Neoplasms
Immunohistochemical molecular markers as predictors of curability of endoscopically resected submucosal colorectal cancer.
Colorectal Neoplasms
Immunohistochemical p53 overexpression correlated to c-erbB-2 and cathepsin D proteins in colorectal cancer.
Colorectal Neoplasms
Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells.
Colorectal Neoplasms
MUC1 and cathepsin D expression in early colorectal carcinoma showing V type pit pattern.
Colorectal Neoplasms
Mutational and expressional analysis of cathepsin D in gastric and colorectal cancers with microsatellite instability.
Colorectal Neoplasms
Novel proteomic strategy reveal combined alpha1 antitrypsin and cathepsin D as biomarkers for colorectal cancer early screening.
Colorectal Neoplasms
Prognostic evaluation of metallothionein expression in human colorectal neoplasms.
Colorectal Neoplasms
Prognostic significance of matrix metalloproteinase-2, cathepsin D, and tenascin-C expression in colorectal carcinoma.
Colorectal Neoplasms
Relationship between cathepsin B, cathepsin D expression and biological behaviour in mucinous colorectal carcinoma.
Colorectal Neoplasms
Resveratrol induces cell death in colorectal cancer cells by a novel pathway involving lysosomal cathepsin D.
Colorectal Neoplasms
Serum proteolytic activities and antiproteases in human colorectal carcinoma.
Colorectal Neoplasms
The expression of multiple proteins as prognostic factors in colorectal cancer: cathepsin D, p53, COX-2, epidermal growth factor receptor, C-erbB-2, and Ki-67.
Colorectal Neoplasms
The immunohistochemical expression of cathepsin D in colorectal cancer.
Colorectal Neoplasms
Tumour budding intensity in relation to cathepsin D expression and some clinicopathological features of colorectal cancer.
Coronary Artery Disease
Beneficial effects of ibuprofen in pacing-induced myocardial ischemia.
Coronary Artery Disease
Cardiac allograft rejection late after transplantation is a risk factor for graft coronary artery disease.
Coronary Artery Disease
Cortical cathepsin D activity and immunolocalization in Alzheimer disease, critical coronary artery disease, and aging.
Coronary Artery Disease
Early recurrent arrhythmias after out-of-hospital cardiac arrest associated with obstructive coronary artery disease: Analysis of the PROCAT registry.
Coronary Artery Disease
Evaluation of serum cathepsin D concentrations in coronary artery disease.
Coronary Artery Disease
Prevalence of Subclinical Coronary Artery Disease in Middle-Aged, Male Marathon Runners Detected by Cardiac CT.
Craniopharyngioma
Cathepsin B, D and K expression in adamantinomatous craniopharyngiomas relates to their levels of differentiation as determined by the patterns of retinoic acid receptor expression.
Creutzfeldt-Jakob Syndrome
Cathepsin D (C224T) Polymorphism in Sporadic and Genetic Creutzfeldt-Jakob Disease.
Creutzfeldt-Jakob Syndrome
Cathepsin D SNP associated with increased risk of variant Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Genetic Association of a Cathepsin D Polymorphism and Sporadic Creutzfeldt-Jakob Disease.
Creutzfeldt-Jakob Syndrome
Involvement of the endosomal-lysosomal system correlates with regional pathology in Creutzfeldt-Jakob disease.
Crohn Disease
Cathepsin D is up-regulated in inflammatory bowel disease macrophages.
Cryptorchidism
The effect of cryptorchidism on the quantitative histology, histochemistry and hydrolytic enzyme activity of the rat testis.
Cystadenoma
Ki-67 staining in benign, borderline, malignant primary and metastatic ovarian tumors: correlation with steroid receptors, epidermal-growth-factor receptor and cathepsin D.
Cystic Fibrosis
The activity of cathepsin D in saliva of cystic fibrosis patients.
Cystinosis
Lysosomal enzymuria is a feature of hereditary Fanconi syndrome and is related to elevated CI-mannose-6-P-receptor excretion.
Cysts
Cathepsin D and epidermal growth factor in human breast cyst fluid.
Cysts
Distribution of Lysosome-associated Membrane Proteins-1 and -2, and Cathepsin D in Eosinophilic Granular Bodies: Possible Relationship to Cyst Development in Pilocytic Astrocytomas.
Cysts
Quantification and molecular analysis of cathepsin D in breast cyst fluids.
Cysts
Relationships between oestrogen-inducible proteins, oestradiol and electrolyte ratio in breast cyst fluid.
Cytomegalovirus Infections
[Effects of HCMV on phenotypes of parotid duct epithelial cells and its mechanisms]
Death, Sudden, Cardiac
Myocardial cathepsin D is downregulated in sudden cardiac death.
Death, Sudden, Cardiac
Significances of viable synergistic autophagy-associated cathepsin B and cathepsin D (CTSB/CTSD) as potential biomarkers for sudden cardiac death.
Dementia
Cathepsin D Polymorphism C224T in Childhood-Onset Neurodegenerative Disorders: No Impact for Childhood Dementia.
Dementia
Identification of Cathepsin D as a Plasma Biomarker for Alzheimer's Disease.
Dementia
Immunodetection of cathepsin D in neuritic plaques found in brains of patients with dementia of Alzheimer type.
Dementia
Lysosomal cathepsin D is upregulated in Alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration.
Dementia
New insights into the roles of endolysosomal cathepsins in the pathogenesis of Alzheimer's disease: cathepsin inhibitors as potential therapeutics.
Dementia, Vascular
Genetic polymorphism in exon 2 of cathepsin D is not associated with vascular dementia.
Demyelinating Diseases
Changes induced in astrocyte cathepsin D by cytokines and leupeptin.
Demyelinating Diseases
The use of protease inhibitors in experimental allergic neuritis.
Dent Disease
Lysosomal enzymuria is a feature of hereditary Fanconi syndrome and is related to elevated CI-mannose-6-P-receptor excretion.
Dermatitis, Phototoxic
Lysosome-associated miniSOG as a photosensitizer for mammalian cells.
Diabetes Mellitus
The role of cathepsin D in the pathophysiology of heart failure and its potentially beneficial properties: a translational approach.
Diabetes Mellitus, Type 1
Urine RAS components in mice and people with type 1 diabetes and chronic kidney disease.
Diabetes Mellitus, Type 2
Exendin-4 stimulates autophagy in pancreatic ?-cells via the RAPGEF/EPAC-Ca2+-PPP3/calcineurin-TFEB axis.
Diabetes Mellitus, Type 2
Increased Cathepsin D Correlates with Clinical Parameters in Newly Diagnosed Type 2 Diabetes.
Diabetes Mellitus, Type 2
Plasma Cathepsin D Activity Rather Than Levels Correlates With Metabolic Parameters of Type 2 Diabetes in Male Individuals.
Diabetic Cardiomyopathies
Lysosomal and nonlysosomal proteolytic activities in experimental diabetic cardiomyopathy.
Diabetic Foot
Cathepsin-D, Adiponectin, TNF-?, IL-6 and hsCRP plasma levels in subjects with diabetic foot and possible correlation with clinical variables: A multicentric study.
Diabetic Foot
Meta-analysis for assessing the healing process of ulcers among diabetic patients: Cases of HbA1c, lipid, S. Creatinine, Adiponectin, Cat D, HSP70, HSP47, 25-hydroxy vitamin D.
Diabetic Nephropathies
Urinary cathepsin L is predictive of changes in albuminuria and correlates with glucosepane in patients with type 2 diabetes in a closed-cohort study.
Diabetic Retinopathy
Cathepsin D plays a role in endothelial-pericyte interactions during alteration of the blood-retinal barrier in diabetic retinopathy.
Diabetic Retinopathy
Cathepsin D: an M?-derived factor mediating increased endothelial cell permeability with implications for alteration of the blood-retinal barrier in diabetic retinopathy.
Diffuse Cerebral Sclerosis of Schilder
Metabolic epilepsies: approaches to a diagnostic challenge.
Disorders of Sex Development
Sex differences in autophagy-mediated diseases: toward precision medicine.
Down Syndrome
Colocalization of lysosomal hydrolase and beta-amyloid in diffuse plaques of the cerebellum and striatum in Alzheimer's disease and Down's syndrome.
Drug-Related Side Effects and Adverse Reactions
CHEMOTHERAPY DRUG RESPONSE IN OVARIAN CANCER CELLS STRICTLY DEPENDS ON A CATHEPSIN D - BAX ACTIVATION LOOP.
Dyslipidemias
Evaluation of serum cathepsin D concentrations in coronary artery disease.
Dysplastic Nevus Syndrome
Activity, expression, and transcription rate of the cathepsins B, D, H, and L in cutaneous malignant melanoma.
Dysplastic Nevus Syndrome
Expression of cathepsin D in primary and metastatic human melanoma and dysplastic nevi.
Encephalomyelitis
Astrocytosis and cathepsin D activity in experimental measles encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Mitigation of experimental allergic encephalomyelitis by cathepsin D inhibition.
Encephalomyelitis, Autoimmune, Experimental
Treatment of experimental allergic encephalomyelitis with an inhibitor of cathepsin D (pepstatin).
Endometrial Neoplasms
Cathepsin D expression in normal, hyperplastic and malignant endometrial tissue: an immunohistochemical analysis.
Endometrial Neoplasms
Cathepsin D expression levels in nongynecological solid tumors: clinical and therapeutic implications.
Endometrial Neoplasms
Differential regulation of cathepsin D by sex steroids in mammary cancer and uterine cells.
Endometrial Neoplasms
Epitope recognition by anti-cathepsin D autoantibodies in endometrial cancer patients.
Endometrial Neoplasms
Estrogen and aryl hydrocarbon responsiveness of ECC-1 endometrial cancer cells.
Endometrial Neoplasms
Hormonal regulation of cathepsin D following transfection of the estrogen or progesterone receptor into three sex steroid hormone resistant cancer cell lines.
Endometrial Neoplasms
Immunohistochemical evaluation of cathepsin D in normal, hyperplastic and malignant endometrium: correlation with hormone receptor status c-erbB-2, p53, Rb proteins and proliferation associated indices.
Endometrial Neoplasms
Immunohistochemical studies concerning cathepsin D in endometrial carcinomas.
Endometrial Neoplasms
Insensitivity of cathepsin D gene to estradiol in endometrial cells is determined by the sequence of its estrogen responsive element.
Endometrial Neoplasms
Low levels of cathepsin D are associated with a poor prognosis in endometrial cancer.
Endometrial Neoplasms
Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer.
Endometrial Neoplasms
May cathepsin D immunoreactivity be used as a prognostic factor in endometrial carcinomas? A comparative immunohistochemical study.
Endometrial Neoplasms
Overexpression and hormonal regulation of pro-cathepsin D in mammary and endometrial cancer.
Endometrial Neoplasms
Quantitative analyses of epidermal growth factor receptors, HER-2/neu oncoprotein and cathepsin D in nonmalignant and malignant uteri.
Endometrial Neoplasms
Significance of cathepsin-D expression in uterine tumours.
Endometrial Neoplasms
[The prognostic value of cathepsin D in endometrial carcinoma]
Endometriosis
Increased concentrations of cathepsin D in peritoneal fluid from women with endometriosis.
Endotoxemia
Plasma lysosomal enzymes in experimental and clinical endotoxemia.
Enterocolitis, Necrotizing
Cathepsin D in intestinal ganglion cells. A potential aid to diagnosis in suspected Hirschsprung's disease.
Epilepsy
Metabolic epilepsies: approaches to a diagnostic challenge.
Esophageal Squamous Cell Carcinoma
Correlation between cathepsin D expression and p53 protein nuclear accumulation in oesophageal squamous cell carcinoma.
Fatty Liver
Cathepsin D regulates lipid metabolism in murine steatohepatitis.
Fatty Liver
Increased plasma cathepsin D concentration in hepatic carcinoma and cirrhosis but not in breast cancer.
Fatty Liver
Inhibiting Extracellular Cathepsin D Reduces Hepatic Steatosis in Sprague?Dawley Rats .
Fatty Liver
Inhibition of Extracellular Cathepsin D Reduces Hepatic Lipid Accumulation and Leads to Mild Changes in Inflammationin NASH Mice.
Fatty Liver
Limited applicability of cathepsin D for the diagnosis and monitoring of non-alcoholic steatohepatitis.
Fatty Liver
Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention.
Fibroadenoma
Correlation between laminin and cathepsin D expressions in breast carcinoma.
Fibrocystic Breast Disease
Cytosol cathepsin D in Thai women with breast cancer.
Fibrocystic Breast Disease
Western blotting and enzymatic activity analysis of cathepsin D in breast tissue and sera of patients with breast cancer and benign breast disease and of normal controls.
Fibromatosis, Aggressive
Immunohistochemical analysis of desmoid tumours.
Fibrosarcoma
Endosomal-lysosomal proteolysis mediates death signalling by TNFalpha, not by etoposide, in L929 fibrosarcoma cells: evidence for an active role of cathepsin D.
Foot Ulcer
Cathepsin-D, Adiponectin, TNF-?, IL-6 and hsCRP plasma levels in subjects with diabetic foot and possible correlation with clinical variables: A multicentric study.
Foot-and-Mouth Disease
T cell-stimulatory fragments of foot-and-mouth disease virus released by mild treatment with cathepsin D.
Frontotemporal Dementia
Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease.
Frontotemporal Dementia
Cathepsin d in a murine model of frontotemporal dementia with parkinsonism-linked to chromosome 17.
Frontotemporal Dementia
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Frontotemporal Dementia
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Frontotemporal Dementia
Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43.
Frontotemporal Lobar Degeneration
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Frontotemporal Lobar Degeneration
Regulation of cathepsin D activity by the FTLD protein progranulin.
Frontotemporal Lobar Degeneration
The role of lysosomes and autophagosomes in frontotemporal lobar degeneration.
Ganglioneuroma
Cathepsin D in intestinal ganglion cells. A potential aid to diagnosis in suspected Hirschsprung's disease.
Gaucher Disease
Aberrant progranulin, YKL-40, cathepsin D and cathepsin S in Gaucher disease.
Geographic Atrophy
Progressive age-related changes similar to age-related macular degeneration in a transgenic mouse model.
Gingivitis
Increase of extracellular cathepsin D activity in gingival washings during experimental gingivitis in man.
Glioblastoma
Adhesive and invasive features in gliomas.
Glioblastoma
Autophagy and lysosomal related protein expression patterns in human glioblastoma.
Glioblastoma
Cathepsin D is a potential serum marker for poor prognosis in glioma patients.
Glioblastoma
Expression of adhesion factors and degrading proteins in primary and secondary glioblastomas and their precursor tumors.
Glioblastoma
Expression of cathepsin D during the progression of human gliomas.
Glioblastoma
Inhibition of Cathepsin D (CTSD) enhances radiosensitivity of glioblastoma cells by attenuating autophagy.
Glioblastoma
Overexpression of Lipocalin-2 Inhibits Proliferation and Invasiveness of Human Glioblastoma Multiforme Cells by Activating ERK Targeting Cathepsin D Expression.
Glioblastoma
Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma.
Glioblastoma
WIN55,212-2 induces caspase-independent apoptosis on human glioblastoma cells by regulating HSP70, p53 and Cathepsin D.
Glioma
Adhesive and invasive features in gliomas.
Glioma
Alterations of the posttranslational processing of a lysosomal enzyme in C6 glioma cells.
Glioma
Cathepsin D and its prognostic value in neuroepithelial brain tumors.
Glioma
Cathepsin D is a potential serum marker for poor prognosis in glioma patients.
Glioma
Expression of cathepsin D during the progression of human gliomas.
Glioma
Inhibition of Cathepsin D (CTSD) enhances radiosensitivity of glioblastoma cells by attenuating autophagy.
Glioma
Inhibition of glioma cell lysosome exocytosis inhibits glioma invasion.
Glioma
Lysosomal ceramide mediates gemcitabine-induced death of glioma cells.
Glioma
Protein alterations associated with temozolomide resistance in subclones of human glioblastoma cell lines.
Glomerulonephritis
Changes in lysosome populations in the rat kidney cortex induced by passive Heymann glomerulonephritis.
Glomerulonephritis
The role of cathepsin D in pathogenesis of acute post-streptococcal glomerulonephritis.
glucan 1,4-alpha-glucosidase deficiency
Immunocytochemical studies of cathepsin D in human skeletal muscle.
Glycogen Storage Disease Type II
Biosynthesis of acid alpha-glucosidase in late-onset forms of glycogenosis type II (Pompe's disease).
Glycogen Storage Disease Type II
Immunocytochemical studies of cathepsin D in human skeletal muscle.
Granuloma
A Comparative Study of Cathepsin D Expression in Peripheral and Central Giant Cell Granuloma of the Jaws by Immunohistochemistry Technique.
Granuloma
Effects of phenylbutazone on the activities of cathepsin D, collagenolytic cathepsin and collagen peptidase in turpentine-induced granuloma.
Granuloma
High gene expression of inflammatory markers and IL-17A correlates with severity of injection site reactions of Atlantic salmon vaccinated with oil-adjuvanted vaccines.
Granuloma
[Lysosomal enzymes of phagocytizing cells in the pathogenesis of inflammation]
Granuloma, Giant Cell
A Comparative Study of Cathepsin D Expression in Peripheral and Central Giant Cell Granuloma of the Jaws by Immunohistochemistry Technique.
Graves Disease
Estrogen receptors and cathepsin D in human thyroid tissue.
Graves Disease
Expression, localization, and thyrotropin regulation of cathepsin D in human thyroid tissues.
Head and Neck Neoplasms
Cathepsin D and PAI-1 expression in human head and neck cancer.
Head and Neck Neoplasms
Expression of cathepsin D in head and neck cancer.
Heart Arrest
Benefit of an early and systematic imaging procedure after cardiac arrest: Insights from the PROCAT (Parisian Region Out of Hospital Cardiac Arrest) registry.
Heart Arrest
Gender differences in early invasive strategy after cardiac arrest: Insights from the PROCAT registry.
Heart Arrest
[Cathepsin D activity and myocardial protein degradation in controlled cardiac arrest during operations with extracorporeal circulation]
Heart Arrest
[Characteristics of the activation of lysosomal enzymes in the rat liver after death and during resuscitation]
Heart Failure
Multidisciplinary rounds (MDR): an implementation system for sustained improvement in the American Heart Association's Get With The Guidelines program.
Heart Failure
Myocardial Upregulation of Cathepsin D by Ischemic Heart Disease Promotes Autophagic Flux and Protects Against Cardiac Remodeling and Heart Failure.
Heart Failure
Proteomic exploration of common pathophysiological pathways in diabetes and cardiovascular disease.
Heart Failure
Role of cathepsin D activation in major adverse cardiovascular events and new-onset heart failure after STEMI.
Heart Failure
The role of cathepsin D in the pathophysiology of heart failure and its potentially beneficial properties: a translational approach.
Heart Neoplasms
[Expression of Cath-D, P-gp and Her-2 in carcinoma of the cardia]
Hemangioendothelioma
Bone hemangioendothelioma: an immunohistochemical study related to histological malignancy and proliferative activity (NORs).
Hemangioma
Splenic littoral cell haemangioendothelioma: a new low-grade variant of malignant littoral cell tumour.
Hepatitis
Lysosomal enzyme activities in normals and in patients with chronic liver diseases.
Hepatitis
Molecular forms of beta-hexosaminidase and cathepsin D in serum and urine of healthy subjects and patients with elevated activity of lysosomal enzymes.
Hepatitis
[Change in the state of liver lysosomes and lymphocytes during development of secondary immunodeficiency and in chronic toxic hepatitis]
Hepatitis B
Glucosamine promotes hepatitis B virus replication through its dual effects in suppressing autophagic degradation and inhibiting MTORC1 signaling.
Hepatitis B
Immunohistological investigations of PAS-negative globular intracisternal hyalin in human liver biopsy specimens.
Hepatitis, Chronic
Lysosomal enzyme activities in normals and in patients with chronic liver diseases.
Herpes Simplex
Functional activity of peritoneal macrophages from sensitive and resistant mouse strains during intravaginal infection with herpes simplex virus type 2 and mucosal vaccination.
Herpes Simplex
Intraoral squamous cell carcinoma in human immunodeficiency virus infection. A clinicopathologic study.
Herpes Simplex
Local and Systemic Functional Responses of Mouse Macrophages to Intravaginal Infection with Type 2 Herpes Simplex Virus and Vaccination.
Herpes Zoster
Vitellogenin transport and yolk formation in the quail ovary.
Herpes Zoster
Vitellogenin, zona radiata protein, cathepsin D and heat shock protein 70 as biomarkers of exposure to xenobiotics.
Hirschsprung Disease
Cathepsin D in intestinal ganglion cells. A potential aid to diagnosis in suspected Hirschsprung's disease.
Histiocytic Sarcoma
Immunophenotypic analysis of extranodal non-Hodgkin's lymphomas in the oral cavity.
Histiocytosis
Cathepsin D and E co-expression in sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) and Langerhans' cell histiocytosis: further evidences of a phenotypic overlap between these histiocytic disorders.
Histiocytosis, Sinus
Cathepsin D and E co-expression in sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) and Langerhans' cell histiocytosis: further evidences of a phenotypic overlap between these histiocytic disorders.
Huntington Disease
Comparison of cathepsin protease activities in brain tissue from normal cases and cases with Alzheimer's disease, Lewy body dementia, Parkinson's disease and Huntington's disease.
Huntington Disease
Elevated levels of the endosomal-lysosomal proteinase cathepsin D in cerebrospinal fluid in Alzheimer disease.
Huntington Disease
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Hydatidiform Mole
The expression of cathepsin D, oestrogen receptor and progestogen receptor in hydatidiform mole--an immunohistochemical study.
Hydatidiform Mole
Use of a novel system for defining a gene imprinting region.
Hyperinsulinism
Euglycemic hyperinsulinemia and hyperaminoacidemia decrease skeletal muscle ubiquitin mRNA in goats.
Hyperlipidemias
The influence of lipoic acid on adriamycin-induced hyperlipidemic nephrotoxicity in rats.
Hypersensitivity
Chromatin structure of the regulatory regions of pS2 and cathepsin D genes in hormone-dependent and -independent breast cancer cell lines.
Hypertension
Aspartic peptidase inhibitors: implications in drug development.
Hypertension
Expression of antiangiogenic prolactin fragments in the placentas of women with pregnancy induced hypertension.
Hypertension
High levels of cathepsin D and cystatin B are associated with increased risk of coronary events.
Hypertension
Proteolytic activities in hypertensive cardiomyopathy of rats.
Hypertension
The relation between serum cathepsin D level and carotid intima-media thickness in nondiabetic hypertensive patients.
Hypertension, Pregnancy-Induced
Expression of antiangiogenic prolactin fragments in the placentas of women with pregnancy induced hypertension.
Hypertension, Pulmonary
Pulmonary pressure reduction attenuates expression of proteins identified by lung proteomic profiling in pulmonary hypertensive rats.
Hyperthyroidism
Effect of altered thyroid status on lysosomal enzymes and thymidylate synthetase activity in tumors and livers of host animals.
Hyperthyroidism
[Effect of somatotropin on cathepsin D in the liver of hypo- and hyperthyroid rats]
Hypertriglyceridemia
Single point mutation in Rabenosyn-5 in a female with intractable seizures and evidence of defective endocytotic trafficking.
Hypokinesia
Effect of motor activity on cathepsin D activity in rat muscles.
Hypokinesia
[Influence of delta-sleep-inducing peptide on the activity of proteolytic enzymes in the rat brain under hypokinesia]
Hypoproteinemia
The influence of lipoic acid on adriamycin-induced hyperlipidemic nephrotoxicity in rats.
Hypotension
Beneficial actions of BN 50739, a new PAF receptor antagonist, in murine traumatic shock.
Hypotension
Plasma lysosomal enzymes in experimental and clinical endotoxemia.
Hypotension
Potentiation of the protective effects of a converting enzyme inhibitor and a thromboxane synthetase inhibitor in hemorrhagic shock.
Hypotension
Protective effects of CG-4203, a novel stable prostacyclin analog, in traumatic shock.
Hypotension
Protective effects of KW-3635, a novel thromboxane A2 antagonist, in murine traumatic shock.
Hypothyroidism
Effect of altered thyroid status on lysosomal enzymes and thymidylate synthetase activity in tumors and livers of host animals.
Infarction, Middle Cerebral Artery
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.
Infarction, Middle Cerebral Artery
Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia.
Infarction, Middle Cerebral Artery
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Infections
Acid Sphingomyelinase Contributes to the Control of Mycobacterial Infection via a Signaling Cascade Leading from Reactive Oxygen Species to Cathepsin D.
Infections
Antiviral and metabolic gene expression responses to viral infection in Atlantic salmon (Salmo salar).
Infections
Are tryptase and cathepsin D related to Helicobacter pylori infection and mucosal gastrin in peptic ulcer?
Infections
Aspartic peptidase inhibitors: implications in drug development.
Infections
Birc1e/Naip5 rapidly antagonizes modulation of phagosome maturation by Legionella pneumophila.
Infections
Characterization of cathepsin D from Eriocheir sinensis involved in Spiroplasma eriocheiris infection.
Infections
Cutting Edge: A Novel Nonoxidative Phagosomal Mechanism Exerted by Cathepsin-D Controls Listeria monocytogenes Intracellular Growth.
Infections
Differential expression profiles in the midgut of Triatoma infestans infected with Trypanosoma cruzi.
Infections
Direct delivery of procathepsin D to phagosomes: implications for phagosome biogenesis and parasitism by Mycobacterium.
Infections
Effect of enterotoxigenic Escherichia coli heat stable toxin on intestinal lysosomal enzymes in the suckling rat.
Infections
Elevated levels of activities of beta-hexosaminidase and alpha-mannosidase in human immunodeficiency virus-infected patients.
Infections
Evidence that Dot-dependent and -independent factors isolate the Legionella pneumophila phagosome from the endocytic network in mouse macrophages.
Infections
Expression profiles of seven channel catfish antimicrobial peptides in response to Edwardsiella ictaluri infection.
Infections
Francisella tularensis strain LVS resides in MHC II-positive autophagic vacuoles in macrophages.
Infections
Functional activity of peritoneal macrophages from sensitive and resistant mouse strains during intravaginal infection with herpes simplex virus type 2 and mucosal vaccination.
Infections
Immunocytochemical evaluation of gastric mucosal cathepsin D in peptic ulcer.
Infections
In-vitro anti-inflammatory and immunomodulatory effects of grepafloxacin in zymogen A- or Staphylococcus aureus-stimulated human THP-1 monocytes.
Infections
Infectivity of Trichomonas vaginalis pseudocysts inoculated intra-vaginally in mice.
Infections
Influence of Helicobacter pylori on tryptase and cathepsin D in peptic ulcer.
Infections
Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons.
Infections
Local and Systemic Functional Responses of Mouse Macrophages to Intravaginal Infection with Type 2 Herpes Simplex Virus and Vaccination.
Infections
Molecular characterization and expression analysis of the channel catfish cathepsin D genes.
Infections
Muscovy duck reovirus promotes virus replication by inhibiting autophagy-lysosomal degradation pathway.
Infections
Protein regulation strategies of the mouse spleen in response to Babesia microti infection.
Infections
Proteomic analysis of murine macrophages mitochondria and lysosomes reveal Cathepsin D as a potential broad-spectrum antimicrobial protein.
Infections
Proteotoxic stress induced by Autographa californica nucleopolyhedrovirus infection of Spodoptera frugiperda Sf9 cells.
Infections
Sequential metabolic alterations in the myocardium during influenza and tularemia in mice.
Infections
The autophagic pathway is actively modulated by phase II Coxiella burnetii to efficiently replicate in the host cell.
Infections
The effect of intracellular Chlamydia psittaci on lysosomal enzyme activities in mouse peritoneal macrophages.
Infections
Trypanosoma cruzi: effects of infection on cathepsin D activity in the midgut of Rhodnius prolixus.
Infections
Virulent and avirulent strains of Francisella tularensis prevent acidification and maturation of their phagosomes and escape into the cytoplasm in human macrophages.
Infections
Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells.
Infections
[Cathepsin D activity in splenocytes in relation to Shigella virulence in an experiment]
Inflammatory Bowel Diseases
Cathepsin D is up-regulated in inflammatory bowel disease macrophages.
Influenza, Human
Glucosamine promotes hepatitis B virus replication through its dual effects in suppressing autophagic degradation and inhibiting MTORC1 signaling.
Influenza, Human
Sequential metabolic alterations in the myocardium during influenza and tularemia in mice.
Influenza, Human
[Role of cathepsin D in the appearance of micronuclei in lung cells of mice immunized with influenza vaccine]
Insulin Resistance
Increased Cathepsin D Correlates with Clinical Parameters in Newly Diagnosed Type 2 Diabetes.
Insulin Resistance
Insulin resistance is positively associated with plasma cathepsin D activity in NAFLD patients.
Insulin Resistance
Plasma cathepsin D activity is negatively associated with hepatic insulin sensitivity in overweight and obese humans.
Insulin Resistance
Plasma Cathepsin D Activity Rather Than Levels Correlates With Metabolic Parameters of Type 2 Diabetes in Male Individuals.
Keloid
Expression of Cathepsins B, D and G by the Embryonic Stem Cell-like Population within Human Keloid Tissues and keloid-derived Primary Cell Lines.
Keratosis
Cathepsin B and D expression in squamous cell carcinoma.
Keratosis
Immunohistochemical expression of cathepsin D in laryngeal epithelial lesions: correlation with CD44 expression, p53 and Rb status and proliferation associated indices.
Kidney Neoplasms
Characteristic [3H]glucosamine-labeled glycoproteins in two-dimensional electrophoretograms of human renal cancer cells: identification as cathepsin D.
Kounis Syndrome
Anaphylactic cardiovascular collapse and Kounis syndrome: systemic vasodilation or coronary vasoconstriction?
Laryngeal Neoplasms
Cathepsin D concentration in primary laryngeal cancer: correlation with clinico-pathological parameters, EGFR status and prognosis.
Laryngeal Neoplasms
Cathepsin D in laryngeal carcinoma. preliminary report.
Laryngeal Neoplasms
Cathepsin D in primary squamous laryngeal tumors: correlation with clinico-pathological parameters and receptor status.
Laryngeal Neoplasms
Expression of cathepsin D and E-cadherin in primary laryngeal cancers correlation with neck lymph node involvement.
Laryngeal Neoplasms
Expression of cathepsin D in malignant and in the corresponding non-malignant node-negative laryngeal samples: correlation with receptors for androgen, glucocorticoid, oestrogen and progesterone.
Laryngeal Neoplasms
Immunohistochemical analysis and prognostic value of cathepsin D determination in laryngeal squamous cell carcinoma.
Laryngeal Neoplasms
Immunohistochemical and immunoradiometric evaluations of total cathepsin D in human larynx.
Leiomyoma
Lipid-rich residual bodies and cathepsin D in the human uterus: ultrastructural and quantitative comparison between normal myometrium and leiomyoma.
Leishmaniasis, Cutaneous
P 53 suppressor gene and cathepsin D expression in correlation with cellular and humoral immunity in cutaneous leishmaniasis.
Leukemia
Antimetastatic activity of adriamycin in combinations with proteinase inhibitors in mice.
Leukemia
Involvement of cathepsin D in chemotherapy-induced cytochrome c release, caspase activation, and cell death.
Leukemia
Resveratrol induces autophagic apoptosis via the lysosomal cathepsin D pathway in human drug-resistant K562/ADM leukemia cells.
Leukemia L1210
Cathepsin D of mouse leukemia L1210 cells. Unusual intracellular localization and biochemical properties.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Cold agglutinin disease following allogeneic bone marrow transplantation.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Glucosamine sulfate-induced apoptosis in chronic myelogenous leukemia K562 cells is associated with translocation of cathepsin D and downregulation of Bcl-xL.
Leukemia, Myeloid
Leukotoxin kills rodent WBC by targeting leukocyte function associated antigen 1.
Lewy Body Disease
Lysosomal cathepsin D is upregulated in Alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration.
Liver Cirrhosis
Cathepsin D serum mass concentrations in patients with hepatocellular carcinoma and/or liver cirrhosis.
Liver Cirrhosis
Changes in the catalytic activities of proteoglycan-degrading lysosomal enzymes in parenchymal and non-parenchymal liver cells and in serum during the development of experimental liver fibrosis.
Liver Cirrhosis
Increased plasma cathepsin D concentration in hepatic carcinoma and cirrhosis but not in breast cancer.
Liver Diseases
Increased plasma cathepsin D concentration in hepatic carcinoma and cirrhosis but not in breast cancer.
Liver Diseases
Myosteatosis in NAFLD patients correlates with plasma Cathepsin D.
Liver Diseases
Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention.
Liver Failure
Hepatic retinopathy: morphological features of retinal glial (Müller) cells accompanying hepatic failure.
Liver Failure, Acute
Characterization of the molecular forms of fibronectin in fulminant hepatic failure.
Liver Neoplasms
[Activity of cathepsin D in the blood serum and urine of patients with cancer of the stomach, pancreas and liver]
Liver Neoplasms, Experimental
Altered intracellular processing and enhanced secretion of procathepsin D in a highly deviated rat hepatoma.
Lung Diseases
The expression and activity of cathepsins d, h and k in asthmatic airways.
Lung Diseases, Interstitial
Changes in collagen metabolism and proteinolysis after repeated inhalation exposure to ozone.
Lung Injury
Cathepsins in bleomycin-induced lung injury in rat.
Lung Neoplasms
Activity and tissue localization of cathepsin D in non small cell lung cancer.
Lung Neoplasms
Cathepsin D expression in skin metastasis of breast cancer.
Lung Neoplasms
Cathepsin D is secreted from M-BE cells: its potential role as a biomarker of lung cancer.
Lung Neoplasms
Cathepsin D messenger RNA is downregulated in human lung cancer.
Lung Neoplasms
Clinicopathological significance of cathepsin D expression in non-small cell lung cancer is conditional on apoptosis-associated protein phenotype: an immunohistochemistry study.
Lung Neoplasms
Comparative autoantibody profiling before and after appearance of malignance: Identification of anti-cathepsin D autoantibody as a promising diagnostic marker for lung cancer.
Lung Neoplasms
Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer.
Lung Neoplasms
Immunostaining of cathepsin-d in nonsmall cell lung-cancer - correlations with morphological and biological parameters.
Lung Neoplasms
Proteomic study of malignant pleural mesothelioma by laser microdissection and two-dimensional difference gel electrophoresis identified cathepsin D as a novel candidate for a differential diagnosis biomarker.
Lung Neoplasms
Secretion of a latent, acid activatable cathepsin L precursor by human non-small cell lung cancer cell lines.
Lung Neoplasms
Skeletal muscle mRNA levels for cathepsin B, but not components of the ubiquitin-proteasome pathway, are increased in patients with lung cancer referred for thoracotomy.
Lung Neoplasms
[Expression and prognostic relation of cathepsin D in non-small cell lung cancer tissues and lymph nodes]
Lymphadenitis
Cathepsin D and E co-expression in sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) and Langerhans' cell histiocytosis: further evidences of a phenotypic overlap between these histiocytic disorders.
Lymphadenopathy
Cathepsin D and E co-expression in sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) and Langerhans' cell histiocytosis: further evidences of a phenotypic overlap between these histiocytic disorders.
Lymphadenopathy
Plasma coenzyme Q10 concentrations in breast cancer: prognosis and therapeutic consequences.
Lymphatic Metastasis
Activity and tissue localization of cathepsin D in non small cell lung cancer.
Lymphatic Metastasis
Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study.
Lymphatic Metastasis
Cathepsin D and PAI-1 expression in human head and neck cancer.
Lymphatic Metastasis
Cathepsin D concentration in primary laryngeal cancer: correlation with clinico-pathological parameters, EGFR status and prognosis.
Lymphatic Metastasis
Cathepsin D expression as a possible predictor of lymph node metastasis in submucosal colorectal cancer.
Lymphatic Metastasis
Correlation of tumor cytosol cathepsin D with differentiation and invasiveness of endometrial adenocarcinoma.
Lymphatic Metastasis
Evaluation of the prognostic significance of cathepsin D, epidermal growth factor receptor, and c-erbB-2 in early cervical squamous cell carcinoma. An immunohistochemical study.
Lymphatic Metastasis
Expression of cathepsin D and E-cadherin in primary laryngeal cancers correlation with neck lymph node involvement.
Lymphatic Metastasis
Expression of cathepsin D and pS2 in imprint smears of breast carcinoma.
Lymphatic Metastasis
Expression of cathepsin D in head and neck cancer.
Lymphatic Metastasis
Identificating cathepsin D as a biomarker for differentiation and prognosis of nasopharyngeal carcinoma by laser capture microdissection and proteomic analysis.
Lymphatic Metastasis
Immunohistochemical detection of nm23/NDP kinase and cathepsin D in medullary carcinomas of the thyroid gland.
Lymphatic Metastasis
Immunohistochemical molecular markers as predictors of curability of endoscopically resected submucosal colorectal cancer.
Lymphatic Metastasis
Predictive value of cathepsin D and Ki-67 expression at the deepest penetration site for lymph node metastases in gastric cancer.
Lymphatic Metastasis
Prognostic significance of the estrogen-regulated protein, cathepsin D, in breast cancer. An immunohistochemical study.
Lymphatic Metastasis
Significance of the tumor protease Cathepsin D for the biology of breast cancer.
Lymphatic Metastasis
The prognostic significance of p53, mdm2, c-erbB-2, cathepsin D, and thrombocytosis in stage IB cervical cancer treated by primary radical hysterectomy.
Lymphatic Metastasis
The prognostic-significance of cathepsin-d in breast carcinomas - an immunohistochemical study.
Lymphatic Metastasis
The value of the lysosomal protease cathepsin-d in egyptian bladder-cancer.
Lymphatic Metastasis
Tumor growth fraction, expression of estrogen and progesterone receptors, p53, bcl-2 and cathepsin D activity in primary ductal invasive breast carcinoma and their axillary lymph node metastases.
Lymphatic Metastasis
Tumour budding intensity in relation to cathepsin D expression and some clinicopathological features of colorectal cancer.
Lymphatic Metastasis
[A histopathologic and immunohistochemical study of prognostic factors in esophageal squamous cell carcinoma]
Lymphatic Metastasis
[Expression of Cath-D, P-gp and Her-2 in carcinoma of the cardia]
Lymphatic Metastasis
[Immunohistochemical study of Cath-D and CD44 in laryngeal squamous cell carcinomas]
Lymphatic Metastasis
[Study of cathepsin D levels in invasive bladder cancer and its stroma. Correlation with tumor stage, cytological grade, lymph node metastasis and survival]
Lymphatic Metastasis
[The expression of Cath-D, c-erbB-2 and EGFR in breast cancer and its correlation to lymphatic metastasis]
Lymphoma
Enhanced Autophagy and Reduced Expression of Cathepsin D Are Related to Autophagic Cell Death in Epstein-Barr Virus-Associated Nasal Natural Killer/T-Cell Lymphomas: An Immunohistochemical Analysis of Beclin-1, LC3, Mitochondria (AE-1), and Cathepsin D in Nasopharyngeal Lymphomas.
Lymphoma
High expression of cathepsin D in non-Hodgkin's lymphomas negatively impacts on clinical outcome.
Lymphoma
HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma.
Lymphoma
Human herpesvirus 8 interleukin-6 contributes to primary effusion lymphoma cell viability via suppression of proapoptotic cathepsin D, a cointeraction partner of vitamin K epoxide reductase complex subunit 1 variant 2.
Lymphoma
Influence of Ukrain and cyclophosphamide administration on HA-1 murine hepatoma and LS lymphoma on aspartic proteinase cathepsin D.
Lymphoma
Insulin-Like Growth Factor 2 Receptor Expression Is Promoted by Human Herpesvirus 8-Encoded Interleukin-6 and Contributes to Viral Latency and Productive Replication.
Lymphoma
Promotion of Endoplasmic Reticulum-Associated Degradation of Procathepsin D by Human Herpesvirus 8-Encoded Viral Interleukin-6.
Lymphoma, B-Cell
Enhanced Autophagy and Reduced Expression of Cathepsin D Are Related to Autophagic Cell Death in Epstein-Barr Virus-Associated Nasal Natural Killer/T-Cell Lymphomas: An Immunohistochemical Analysis of Beclin-1, LC3, Mitochondria (AE-1), and Cathepsin D in Nasopharyngeal Lymphomas.
Lymphoma, B-Cell
Glucosamine sulfate-induced apoptosis in chronic myelogenous leukemia K562 cells is associated with translocation of cathepsin D and downregulation of Bcl-xL.
Lymphoma, B-Cell
Immunophenotypic analysis of extranodal non-Hodgkin's lymphomas in the oral cavity.
Lymphoma, Non-Hodgkin
Influence of Ukrain and cyclophosphamide administration on HA-1 murine hepatoma and LS lymphoma on aspartic proteinase cathepsin D.
Lymphoma, Primary Effusion
HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma.
Lymphoma, Primary Effusion
Human herpesvirus 8 interleukin-6 contributes to primary effusion lymphoma cell viability via suppression of proapoptotic cathepsin D, a cointeraction partner of vitamin K epoxide reductase complex subunit 1 variant 2.
Lymphoma, Primary Effusion
Insulin-Like Growth Factor 2 Receptor Expression Is Promoted by Human Herpesvirus 8-Encoded Interleukin-6 and Contributes to Viral Latency and Productive Replication.
Lymphoma, Primary Effusion
Promotion of Endoplasmic Reticulum-Associated Degradation of Procathepsin D by Human Herpesvirus 8-Encoded Viral Interleukin-6.
Lymphoma, T-Cell
Enhanced Autophagy and Reduced Expression of Cathepsin D Are Related to Autophagic Cell Death in Epstein-Barr Virus-Associated Nasal Natural Killer/T-Cell Lymphomas: An Immunohistochemical Analysis of Beclin-1, LC3, Mitochondria (AE-1), and Cathepsin D in Nasopharyngeal Lymphomas.
Lymphoma, T-Cell
Immunophenotypic analysis of extranodal non-Hodgkin's lymphomas in the oral cavity.
Lymphopenia
CNS-expressed cathepsin D prevents lymphopenia in a murine model of congenital neuronal ceroid lipofuscinosis.
Lysosomal Storage Diseases
A mutation in the ovine cathepsin D gene causes a congenital lysosomal storage disease with profound neurodegeneration.
Lysosomal Storage Diseases
Haematopoietic development and immunological function in the absence of cathepsin D.
Lysosomal Storage Diseases
Neuronal and microglial cathepsins in aging and age-related diseases.
Lysosomal Storage Diseases
Presynaptic Endosomal Cathepsin D Regulates the Biogenesis of GABAergic Synaptic Vesicles.
Lysosomal Storage Diseases
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Macular Degeneration
Distribution of cathepsin D in human eyes with or without age-related maculopathy.
Malaria
Aspartic peptidase inhibitors: implications in drug development.
Malaria
Differential requirement for cathepsin D for processing of the full length and C-terminal fragment of the malaria antigen MSP1.
Malaria
Enzymatic Characterization of Recombinant Food Vacuole Plasmepsin 4 from the Rodent Malaria Parasite Plasmodium berghei.
Malaria
Identification of Sulfamoylbenzamide derivatives as selective Cathepsin D inhibitors.
Malaria
Purification of Plasmodium lophurae cathepsin D and its effects on erythrocyte membrane proteins.
Malnutrition
Lack of evidence for elevated breakdown rate of skeletal muscles in weight-losing, tumor-bearing mice.
Mastitis
Peptidomic analysis of healthy and subclinically mastitic bovine milk.
Mastocytoma
[Activity of proteolytic enzymes and their inhibitors during proliferation of P-815 mastocytoma cell proliferation in vitro]
Measles
Astrocytosis and cathepsin D activity in experimental measles encephalomyelitis.
Melanoma
Activity of cathepsin D and ?1-antitrypsin in blood of men with malignant melanoma.
Melanoma
Activity, expression, and transcription rate of the cathepsins B, D, H, and L in cutaneous malignant melanoma.
Melanoma
B16 melanoma secretomes and in vitro invasiveness: syntenin as an invasion modulator.
Melanoma
Biomarker discovery from uveal melanoma secretomes: identification of gp100 and cathepsin D in patient serum.
Melanoma
Cathepsin D expression in early cutaneous malignant melanoma.
Melanoma
Effect of trypan blue on the activity of lysosomal enzymes, tumor growth and cell ultrastructure in B16 melanotic melanoma in mice.
Melanoma
Expression of cathepsin D in primary and metastatic human melanoma and dysplastic nevi.
Melanoma
Function of liver activation-regulated chemokine/CC chemokine ligand 20 is differently affected by cathepsin B and cathepsin D processing.
Melanoma
Gamma-IFN-inducible-lysosomal thiol reductase modulates acidic proteases and HLA class II antigen processing in melanoma.
Melanoma
Influence of quercetin on B16 melanotic melanoma growth in C57BL/6 mice and on activity of some acid hydrolases in melanoma tissue.
Melanoma
Interaction of cationic ultrasmall superparamagnetic iron oxide nanoparticles with human melanoma cells.
Melanoma
Overexpression of cathepsin D in malignant melanoma.
Melanoma
Quantification of cathepsin D in plasma of patients with malignant melanoma.
Melanoma
Targeted Multiple Reaction Monitoring Analysis of CSF Identifies UCHL1 and GPNMB as Candidate Biomarkers for ALS.
Melanoma
Transparent polyamide: a promising new material for microscopic slides.
Melanoma, Amelanotic
Activity of some lysosomal hydrolases in the homogenates of transplantable melanotic and amelanotic melanoma in golden hamster (Mesocricetus auratus, Waterhouse).
Meningioma
Expression of extracellular matrix-degrading proteins in classic, atypical, and anaplastic meningiomas.
Meningioma
Immunohistochemical characterization of brain-invasive meningiomas.
Meningioma
Immunohistochemical expression of cathepsin D in meningiomas.
Meningioma
Influence of preoperative dexamethasone therapy on proliferating cell nuclear antigen (PCNA) expression in comparison to other parameters in meningiomas.
Meningioma
Progesterone receptor synthesis in human meningiomas: relation to the estrogen-induced proteins pS2 and cathepsin-D and influence of epidermal growth factor, Forskolin and phorbol ester in vitro.
Mesothelioma
Proteomic study of malignant pleural mesothelioma by laser microdissection and two-dimensional difference gel electrophoresis identified cathepsin D as a novel candidate for a differential diagnosis biomarker.
Mesothelioma, Malignant
Proteomic study of malignant pleural mesothelioma by laser microdissection and two-dimensional difference gel electrophoresis identified cathepsin D as a novel candidate for a differential diagnosis biomarker.
Metabolic Syndrome
Effect of Curcumin on Serum Cathepsin D in Patients with Metabolic Syndrome.
Metabolic Syndrome
Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells.
Metrorrhagia
Immunohistochemical detection of cathepsin D in endometrium from long-term subdermal levonorgestrel users and during the normal menstrual cycle.
Mouth Neoplasms
Immunohistochemical Expression of Cathepsin D in Primary and Recurrent Squamous Cell Carcinoma.
Mucolipidoses
Impaired phosphorylation of lysosomal enzymes in fibroblasts of patients with mucolipidosis III.
Mucolipidoses
Molecular forms of beta-hexosaminidase and cathepsin D in serum and urine of healthy subjects and patients with elevated activity of lysosomal enzymes.
Mucositis
Beneficial effects of cathepsin inhibition to prevent chemotherapy-induced intestinal mucositis.
Mucositis
Chemotherapy-induced mucositis is associated with changes in proteolytic pathways.
Multiple Sclerosis
Acidic lipids enhance cathepsin D cleavage of the myelin basic protein.
Multiple Sulfatase Deficiency Disease
Enhanced breakdown of arylsulfatase A in multiple sulfatase deficiency.
Muscular Diseases
Immunohistochemical evidence for amyloid beta in rat soleus muscle in chloroquine-induced myopathy.
Muscular Diseases
Knock-down of Cathepsin D in zebrafish fertilized eggs determines congenital myopathy.
Muscular Diseases
The role of proteases in experimental glucocorticoid myopathy.
Muscular Dystrophies
Immunocytochemical studies of cathepsin D in human skeletal muscle.
Muscular Dystrophies
Lysosomal and nonlysosomal hydrolases of skeletal muscle in neuromuscular diseases.
Mycoses
[The histamine-serotonin-monoamine oxidase system in patients with foot mycosis during treatment]
Myocardial Infarction
Admission Value of Serum Cathepsin D Level Can be Useful for Predicting In-Hospital Mortality in Patients with NSTEMI.
Myocardial Infarction
Cathepsin D improves the prediction of undetected diabetes in patients with myocardial infarction.
Myocardial Infarction
Influence of isoproterenol-induced myocardial infarction on certain glycohydrolases and cathepsins in rats.
Myocardial Infarction
Mild hyperhomocysteinemia is associated with a decreased fibrinolytic activity in patients after ST-elevation myocardial infarction.
Myocardial Infarction
Plasma cathepsin D isoforms and their active metabolites increase after myocardial infarction and contribute to plasma renin activity.
Myocardial Infarction
Role of cathepsin D activation in major adverse cardiovascular events and new-onset heart failure after STEMI.
Myocardial Ischemia
An increase of cathepsin D activity in cardiac lymph and pericadial fluid induced by experimental myocardial ischemia in the dog.
Myocardial Ischemia
Biochemical and immunological studies of lysosomal and related proteinases in health and disease.
Myocardial Ischemia
Influence of methylprednisolone of the sequential redistribution of cathepsin D and other lysosomal enzymes during myocardial ischemia in rabbits.
Myocardial Ischemia
Lysosomal hypothesis in evolution of myocardial infarction. Subcellular fractionation and electron microscopic cytochemical study.
Myocardial Ischemia
Myocardial ischemia and reperfusion injury in rats: lysosomal hydrolases and matrix metalloproteinases mediated cellular damage.
Myocardial Ischemia
Myocardial Upregulation of Cathepsin D by Ischemic Heart Disease Promotes Autophagic Flux and Protects Against Cardiac Remodeling and Heart Failure.
Myositis
Immunocytochemical studies of cathepsin D in human skeletal muscle.
Myositis
Ubiquitinated inclusions in inclusion-body myositis patients are immunoreactive for cathepsin D but not beta-amyloid.
Nasal Polyps
Cathepsin D activity in nasal polyps.
Nasal Polyps
SPR Imaging Biosensor for Aspartyl Cathepsins: Sensor Development and Application for Biological Material.
Nasopharyngeal Carcinoma
Identificating cathepsin D as a biomarker for differentiation and prognosis of nasopharyngeal carcinoma by laser capture microdissection and proteomic analysis.
Neoplasm Metastasis
A novel aspartic protease gene, ALP56, is up-regulated in human breast cancer independently from the cathepsin D gene.
Neoplasm Metastasis
Activity and tissue localization of cathepsin D in non small cell lung cancer.
Neoplasm Metastasis
Alterations and role of human cathepsin D in cancer metastasis.
Neoplasm Metastasis
Altered gene expression profiles of NIH3T3 cells regulated by human lung cancer associated gene CT120.
Neoplasm Metastasis
Angiostatin generation by cathepsin D secreted by human prostate carcinoma cells.
Neoplasm Metastasis
Aspartic peptidase inhibitors: implications in drug development.
Neoplasm Metastasis
Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study.
Neoplasm Metastasis
Benzophenone-1 and nonylphenol stimulated MCF-7 breast cancer growth by regulating cell cycle and metastasis-related genes via an estrogen receptor ?-dependent pathway.
Neoplasm Metastasis
Biological and clinical significance of cathepsin D in breast cancer metastasis.
Neoplasm Metastasis
Biological and clinical significance of cathepsin D in breast cancer.
Neoplasm Metastasis
Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure-Activity Relationship and Binding Mode Analysis.
Neoplasm Metastasis
Breast-conserving therapy: proteases as risk factors in relation to survival after local relapse.
Neoplasm Metastasis
Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: The role of hypoxia inducible factor 1 pathway.
Neoplasm Metastasis
c-Myb regulates matrix metalloproteinases 1/9, and cathepsin D: implications for matrix-dependent breast cancer cell invasion and metastasis.
Neoplasm Metastasis
CA 15-3 serum levels in patients with ductal breast carcinoma: relationship with clinicopathological parameters and tumor markers.
Neoplasm Metastasis
Calcium-binding protein S100P and cancer: mechanisms and clinical relevance.
Neoplasm Metastasis
Capillary electrophoretic determination of cathepsin D activity using Oregon Green-labeled hemoglobin.
Neoplasm Metastasis
Cathepsin D and PAI-1 expression in human head and neck cancer.
Neoplasm Metastasis
Cathepsin D concentration in breast cancer cytosols: correlation with disease-free interval and overall survival.
Neoplasm Metastasis
Cathepsin D concentration in primary laryngeal cancer: correlation with clinico-pathological parameters, EGFR status and prognosis.
Neoplasm Metastasis
Cathepsin D enhances breast cancer invasion and metastasis through promoting hepsin ubiquitin-proteasome degradation.
Neoplasm Metastasis
Cathepsin D expression as a possible predictor of lymph node metastasis in submucosal colorectal cancer.
Neoplasm Metastasis
Cathepsin D Expression in Colorectal Cancer: From Proteomic Discovery through Validation Using Western Blotting, Immunohistochemistry, and Tissue Microarrays.
Neoplasm Metastasis
Cathepsin D expression in renal cell cancer-clinical implications.
Neoplasm Metastasis
Cathepsin D expression in skin metastasis of breast cancer.
Neoplasm Metastasis
Cathepsin D immunostaining in paraffin-embedded breast cancer cells and macrophages: correlation with cytosolic assay.
Neoplasm Metastasis
Cathepsin D in breast cancer cells can digest extracellular matrix in large acidic vesicles.
Neoplasm Metastasis
Cathepsin D in breast cancer.
Neoplasm Metastasis
Cathepsin D in breast cancer: a tissue marker associated with metastasis.
Neoplasm Metastasis
Cathepsin D in breast cancer: from molecular and cellular biology to clinical applications.
Neoplasm Metastasis
Cathepsin D in breast cancer: mechanisms and clinical applications, a 1999 overview.
Neoplasm Metastasis
Cathepsin D in cancer metastasis: a protease and a ligand.
Neoplasm Metastasis
Cathepsin D in the malignant progression of neoplastic diseases (review).
Neoplasm Metastasis
Cathepsin D maturation and its stimulatory effect on metastasis are prevented by addition of KDEL retention signal.
Neoplasm Metastasis
Cathepsin D non-proteolytically induces proliferation and migration in human omental microvascular endothelial cells via activation of the ERK1/2 and PI3K/AKT pathways.
Neoplasm Metastasis
Cathepsin D serum levels are not a valid serum marker in renal cell carcinoma.
Neoplasm Metastasis
Cathepsin D specifically cleaves the chemokines macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, and SLC that are expressed in human breast cancer.
Neoplasm Metastasis
Cathepsin D stimulates the activities of secreted plasminogen activators in the breast cancer acidic environment.
Neoplasm Metastasis
Cathepsin D, both a prognostic factor and a predictive factor for the effect of adjuvant tamoxifen in breast cancer. South Sweden Breast Cancer Group.
Neoplasm Metastasis
Cathepsin D-related disease-free interval in pT1 primary breast carcinomas: a pilot study.
Neoplasm Metastasis
Cathepsin D: a protease involved in breast cancer metastasis.
Neoplasm Metastasis
Cathepsin D: an independent prognostic factor for metastasis of breast cancer.
Neoplasm Metastasis
Cathepsin D: newly discovered functions of a long-standing aspartic protease in cancer and apoptosis.
Neoplasm Metastasis
Cathepsin-D and c-erb-B 2 have an additive prognostic value for breast cancer patients.
Neoplasm Metastasis
Cathepsin-D, urokinase plasminogen activator and type-1 plasminogen activator inhibitor in early breast cancer: an immunohistochemical study of prognostic value and relations to tenascin-C and other factors.
Neoplasm Metastasis
CD44 expression in colorectal cancer. An immunohistochemical study including correlation with cathepsin D immunoreactivity and some tumour clinicopathological features.
Neoplasm Metastasis
Cervical lymph node status and survival in laryngeal carcinoma: prognostic factors.
Neoplasm Metastasis
Characterization and enumeration of cells secreting tumor markers in the peripheral blood of breast cancer patients.
Neoplasm Metastasis
Characterization of protease expression in human prostate-cancer cell-lines.
Neoplasm Metastasis
Characterization of the proximal estrogen-responsive element of human cathepsin D gene.
Neoplasm Metastasis
Co-chaperone BAG2 Determines the Pro-oncogenic Role of Cathepsin B in Triple-Negative Breast Cancer Cells.
Neoplasm Metastasis
Comparative biochemical and immunohistochemical studies on the cathepsin D content of human breast cancer.
Neoplasm Metastasis
Correlation of tumor cytosol cathepsin D with differentiation and invasiveness of endometrial adenocarcinoma.
Neoplasm Metastasis
CORRELATIONSHIP OF CATHEPSIN D AND TOPOISOMERASE II ALPHA WITH NUCLEAR GRADING IN BREAST CANCERS.
Neoplasm Metastasis
Cyanobacterial peptides as a prototype for the design of cathepsin D inhibitors.
Neoplasm Metastasis
Decreased secretion of Cathepsin D in breast cancer in vivo by tamoxifen: mediated by the mannose-6-phosphate/IGF-II receptor?
Neoplasm Metastasis
Design, synthesis, and bioactivities of tasiamide B derivatives as cathepsin D inhibitors.
Neoplasm Metastasis
Detection of oral squamous cell carcinoma metastasis with cathepsin D: An immunohistochemical approach.
Neoplasm Metastasis
Detection of protein alterations in male breast cancer using two dimensional gel electrophoresis and mass spectrometry: the involvement of several pathways in tumorigenesis.
Neoplasm Metastasis
Differentiation and cathepsin D expression in human oral tumors.
Neoplasm Metastasis
Distribution of cathepsin D granules in normal and pathologic conditions in human prostate.
Neoplasm Metastasis
Effects of cathepsin D inhibitor from Vicia sativa L. seed hulls on human skin fibroblasts and breast cancer cells (in vitro studies).
Neoplasm Metastasis
Effects of cigarette smoke extracts on cell cycle, cell migration and endocrine activity in human placental cells.
Neoplasm Metastasis
Elevated levels of pro-cathepsin-d in the plasma of breast-cancer patients.
Neoplasm Metastasis
Elucidating the function of secreted maspin: inhibiting cathepsin D-mediated matrix degradation.
Neoplasm Metastasis
Evaluation of cathepsin D and epidermal growth factor receptor in prostate carcinoma.
Neoplasm Metastasis
Evaluation of the prognostic significance of cathepsin D, epidermal growth factor receptor, and c-erbB-2 in early cervical squamous cell carcinoma. An immunohistochemical study.
Neoplasm Metastasis
Exploring targeted therapy of osteosarcoma using proteomics data.
Neoplasm Metastasis
Expression of cathepsin D and B in invasion and metastasis of squamous cell carcinoma.
Neoplasm Metastasis
Expression of cathepsin D and E-cadherin in primary laryngeal cancers correlation with neck lymph node involvement.
Neoplasm Metastasis
Expression of cathepsin D and galectin 3 in tubular carcinomas of the breast.
Neoplasm Metastasis
Expression of cathepsin D and pS2 in imprint smears of breast carcinoma.
Neoplasm Metastasis
Expression of cathepsin D during the progression of human gliomas.
Neoplasm Metastasis
Expression of cathepsin D in head and neck cancer.
Neoplasm Metastasis
Expression of syndecan-1 and cathepsins D and K in advanced esophageal squamous cell carcinoma.
Neoplasm Metastasis
Expression, localization, and thyrotropin regulation of cathepsin D in human thyroid tissues.
Neoplasm Metastasis
Factors associated with bone metastasis in breast cancer: a preliminary study in an indonesian population.
Neoplasm Metastasis
Glycoprotein CD44 expression in colorectal neoplasms. An immuno-histochemical study including correlation with cathepsin D, extracellular matrix components, p53, Rb, bcl-2, c-erbB-2, EGFR and proliferation indices.
Neoplasm Metastasis
Graphene Oxide-Based Targeting of Extracellular Cathepsin D and Cathepsin L As A Novel Anti-Metastatic Enzyme Cancer Therapy.
Neoplasm Metastasis
Growth and differentiation of the normal mammary gland and its tumours.
Neoplasm Metastasis
Identificating cathepsin D as a biomarker for differentiation and prognosis of nasopharyngeal carcinoma by laser capture microdissection and proteomic analysis.
Neoplasm Metastasis
Immunohistochemical analysis and prognostic value of cathepsin D determination in laryngeal squamous cell carcinoma.
Neoplasm Metastasis
Immunohistochemical detection of cathepsin D in low grade breast invasive cancer.
Neoplasm Metastasis
Immunohistochemical detection of nm23/NDP kinase and cathepsin D in medullary carcinomas of the thyroid gland.
Neoplasm Metastasis
Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: their prognostic value and role in tumour invasion and progression.
Neoplasm Metastasis
Immunohistochemical localization of cathepsin D in colorectal tumors.
Neoplasm Metastasis
Immunohistochemical molecular markers as predictors of curability of endoscopically resected submucosal colorectal cancer.
Neoplasm Metastasis
Immunohistochemical visualisation of cathepsin-D expression in breast cancer.
Neoplasm Metastasis
Immunoradiometric assay of pro-cathepsin D in breast cancer cytosol: relative prognostic value versus total cathepsin D.
Neoplasm Metastasis
Increased cathepsin D protein expression is a biomarker for osteosarcomas, pulmonary metastases and other bone malignancies.
Neoplasm Metastasis
Increased plasma cathepsin D concentration in hepatic carcinoma and cirrhosis but not in breast cancer.
Neoplasm Metastasis
Induction of cathepsin D protein during estrogen carcinogenesis: possible role in estrogen-mediated kidney tubular cell damage.
Neoplasm Metastasis
Inhibition of breast cancer growth by suramin.
Neoplasm Metastasis
Micro-lymph node metastasis and its correlation with cathepsin D expression in early gastric cancer.
Neoplasm Metastasis
Missense polymorphism (C/T224) in the human cathepsin D pro-fragment determined by polymerase chain reaction--single strand conformational polymorphism analysis and possible consequences in cancer cells.
Neoplasm Metastasis
Nm23 and cathepsin D expression in laryngeal carcinomas.
Neoplasm Metastasis
Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells.
Neoplasm Metastasis
Oestrogens, proteases and breast cancer. From cell lines to clinical applications.
Neoplasm Metastasis
Olfactomedin 4 Suppresses Prostate Cancer Cell Growth and Metastasis via Negative Interaction with Cathepsin D and SDF-1.
Neoplasm Metastasis
Osteoprotegerin expression in triple-negative breast cancer cells promotes metastasis.
Neoplasm Metastasis
Overexpression of transfected cathepsin D in transformed cells increases their malignant phenotype and metastatic potency.
Neoplasm Metastasis
Pathophysiological functions of cathepsin D: Targeting its catalytic activity versus its protein binding activity?
Neoplasm Metastasis
Potential markers predicting distant metastasis in axillary node-negative breast carcinoma.
Neoplasm Metastasis
Predictive value of cathepsin D and Ki-67 expression at the deepest penetration site for lymph node metastases in gastric cancer.
Neoplasm Metastasis
Prognostic indicators for early-stage breast-carcinoma .2. Value of cathepsin-d expression, detected by immunocytochemistry - a multiparametric study.
Neoplasm Metastasis
Prognostic significance of the estrogen-regulated protein, cathepsin D, in breast cancer. An immunohistochemical study.
Neoplasm Metastasis
Prognostic value of Cathepsin D expression in breast cancer: immunohistochemical assessment and correlation with radiometric assay.
Neoplasm Metastasis
Prognostic value of plasminogen activator inhibitor-1 in head and neck squamous cell carcinoma.
Neoplasm Metastasis
Proliferation Markers and EGF in ACTH-Secreting Adenomas and Carcinomas of the Pituitary.
Neoplasm Metastasis
Quantification of cathepsin D in plasma of patients with malignant melanoma.
Neoplasm Metastasis
Quantitative immunohistochemical determination of cathepsin D levels in prostatic carcinoma biopsies. Correlation with tumor grade, stage, PSA level, and DNA ploidy status.
Neoplasm Metastasis
Regulation, clinical and biological significance of cathepsin D in breast cancer.
Neoplasm Metastasis
Relationship between cathepsin D and other pathological and biological parameters in 1752 patients with primary breast cancer.
Neoplasm Metastasis
Serum levels of Hemorphin-7 peptides in patients with breast cancer.
Neoplasm Metastasis
Significance of the tumor protease Cathepsin D for the biology of breast cancer.
Neoplasm Metastasis
Structure-based subsite specificity mapping of human cathepsin D using statine-based inhibitors.
Neoplasm Metastasis
Tenascin C and cathepsin d expression in adipocytic tumors: an immunohistochemical investigation of 43 cases.
Neoplasm Metastasis
The effect of combined therapy on activity of cathepsin D and alpha-1-antitrypsin in the blood serum of women with cervical cancer.
Neoplasm Metastasis
The immunohistochemical expression of cathepsin D in colorectal cancer.
Neoplasm Metastasis
The Potential Role of the Proteases Cathepsin D and Cathepsin L in the Progression and Metastasis of Epithelial Ovarian Cancer.
Neoplasm Metastasis
The prognostic significance of p53, mdm2, c-erbB-2, cathepsin D, and thrombocytosis in stage IB cervical cancer treated by primary radical hysterectomy.
Neoplasm Metastasis
The prognostic-significance of cathepsin-d in breast carcinomas - an immunohistochemical study.
Neoplasm Metastasis
The propeptide of cathepsin D increases proliferation, invasion and metastasis of breast cancer cells.
Neoplasm Metastasis
The role of cathepsin D in the invasiveness of human breast cancer cells.
Neoplasm Metastasis
The role of proteolytic enzymes in cancer invasion and metastasis.
Neoplasm Metastasis
The value of the lysosomal protease cathepsin-d in egyptian bladder-cancer.
Neoplasm Metastasis
Thrombin up-regulates cathepsin D which enhances angiogenesis, growth, and metastasis.
Neoplasm Metastasis
Transfected cathepsin D stimulates high density cancer cell growth by inactivating secreted growth inhibitors.
Neoplasm Metastasis
Tumor growth fraction, expression of estrogen and progesterone receptors, p53, bcl-2 and cathepsin D activity in primary ductal invasive breast carcinoma and their axillary lymph node metastases.
Neoplasm Metastasis
Tumour budding intensity in relation to cathepsin D expression and some clinicopathological features of colorectal cancer.
Neoplasm Metastasis
Tumour-associated fibrinolysis: the prognostic relevance of plasminogen activators uPA and tPA in human breast cancer.
Neoplasm Metastasis
Variable expression of cathepsin B and D correlates with highly invasive and metastatic phenotype of oral cancer.
Neoplasm Metastasis
Western blotting and enzymatic activity analysis of cathepsin D in breast tissue and sera of patients with breast cancer and benign breast disease and of normal controls.
Neoplasm Metastasis
Western immunoblotting and enzymatic activity analysis of cathepsin D in human breast cancer cell lines of different invasive potential. Regulation by 17beta-estradiol, tamoxifen and ICI 182,780.
Neoplasm Metastasis
[A histopathologic and immunohistochemical study of prognostic factors in esophageal squamous cell carcinoma]
Neoplasm Metastasis
[Activity of cathepsin D in the blood serum and urine of patients with cancer of the stomach, pancreas and liver]
Neoplasm Metastasis
[Cathepsin D in diagnosis of neoplastic diseases]
Neoplasm Metastasis
[Cathepsin D in primary breast cancer in correlation with various prognostic factors]
Neoplasm Metastasis
[Estrogens, cathepsin D and metastasis in cancers of the breast and ovary: invasion or proliferation?]
Neoplasm Metastasis
[Expression of Cath-D, P-gp and Her-2 in carcinoma of the cardia]
Neoplasm Metastasis
[Hormonal regulation in breast cancer from cell lines to patients]
Neoplasm Metastasis
[Immunohistochemical study of Cath-D and CD44 in laryngeal squamous cell carcinomas]
Neoplasm Metastasis
[Involvement of cathepsin D and cathepsin E in the inhibition of tumor growth and metastasis through the production of angiogenetic inhibitors]
Neoplasm Metastasis
[Mechanism of the overexpression of the cathepsin D gene in breast cancer and consequences in the metastatic process]
Neoplasm Metastasis
[Proteolytic enzyme activity in stomach cancer patients with various prognoses]
Neoplasm Metastasis
[Study of cathepsin D levels in invasive bladder cancer and its stroma. Correlation with tumor stage, cytological grade, lymph node metastasis and survival]
Neoplasm Metastasis
[Study of the cytosolic concentrations of the tissue poly-peptide specific (TPS) antigen in infiltrating ductal carcinomas of the breast. Positive relationship with hormone dependency and negative with cellular proliferation]
Neoplasm Metastasis
[The expression of Cath-D, c-erbB-2 and EGFR in breast cancer and its correlation to lymphatic metastasis]
Neoplasm Metastasis
[The expression of cathepsin-D in salivary adenoid cystic carcinoma]
Neoplasm Metastasis
[The prognostic value of cathepsin D concentration in cytosol of primary breast carcinoma]
Neoplasm Metastasis
[The relationship between prognosis, metastasis and microvessel quantity in invasive breast carcinoma]
Neoplasm Micrometastasis
American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer.
Neoplasms
A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment.
Neoplasms
A high-resolution linkage map for comparative genome analysis and QTL fine mapping in Asian seabass, Lates calcarifer.
Neoplasms
A lysosomal pepstatin-insensitive proteinase as a novel biomarker for breast carcinoma.
Neoplasms
A novel aspartic protease gene, ALP56, is up-regulated in human breast cancer independently from the cathepsin D gene.
Neoplasms
A novel bis-aryl urea compound inhibits tumor proliferation via cathepsin D-associated apoptosis.
Neoplasms
A paramagnetic chemical exchange-based MRI probe metabolized by cathepsin D: design, synthesis and cellular uptake studies.
Neoplasms
A prognostic model to predict outcome of patients failing to achieve pathological complete response after anthracycline-containing neoadjuvant chemotherapy for breast cancer.
Neoplasms
A prospective prognostic study of the hormonal milieu at the time of surgery in premenopausal breast carcinoma.
Neoplasms
A two-site immunoenzymometric assay of 52-kDa pro-cathepsin D, and its use in human breast diseases.
Neoplasms
Aberrant cystatin-C expression in blood from patients with breast cancer is a suitable marker for monitoring tumor burden.
Neoplasms
Action of endogenous proteases on the distribution of tyrosinase isozymes in Harding-Passey mouse melanoma.
Neoplasms
Activity and tissue localization of cathepsin D in non small cell lung cancer.
Neoplasms
Activity of cathepsin B and D in colorectal cancer: relationships with tumour budding.
Neoplasms
Activity of some lysosomal enzymes in serum and in tumors of patients with squamous cell lung carcinoma.
Neoplasms
Activity of some lysosomal hydrolases in the homogenates of transplantable melanotic and amelanotic melanoma in golden hamster (Mesocricetus auratus, Waterhouse).
Neoplasms
Adenosquamous carcinoma of the gall-bladder with gastric foveolar-type epithelium.
Neoplasms
Adhesive and invasive features in gliomas.
Neoplasms
Adjuvant therapy of node-negative breast cancer.
Neoplasms
Age-associated biomarker profiles of human breast cancer.
Neoplasms
Age-dependent changes in breast cancer hormone receptors and oxidant stress markers.
Neoplasms
AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D.
Neoplasms
Allylic structures in cancer drugs and body metabolites that control cell life and death.
Neoplasms
Aloe vera and Honey Solution and Their Ethanolic Extraction Solution Could Act on Metastasis-Regulating Processes in Walker 256 Tumor Tissues In Vivo?
Neoplasms
Alpha1-antichymotrypsin and kallistatin hydrolysis by human cathepsin D.
Neoplasms
Alterations and role of human cathepsin D in cancer metastasis.
Neoplasms
Altered gene expression profiles of NIH3T3 cells regulated by human lung cancer associated gene CT120.
Neoplasms
American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer.
Neoplasms
An aggressive desmoid tumor in a patient with familial adenomatous polyposis: immunohistochemical findings.
Neoplasms
An immunohistochemical and prognostic evaluation of cathepsin D expression in 105 bladder carcinomas.
Neoplasms
An immunohistochemical assessment of cathepsin D in gastric carcinoma: its impact on clinical prognosis.
Neoplasms
Analysis of C-myc amplification by the differential polymerase chain-reaction (d-PCR), study in breast-cancer.
Neoplasms
Angiostatin generation by cathepsin D secreted by human prostate carcinoma cells.
Neoplasms
Anti-cathepsin D chicken IgY antibodies: characterisation, cross-species reactivity and application in immunogold labelling of human splenic neutrophils and fibroblasts.
Neoplasms
Association between high concentrations of Mr 52,000 cathepsin D and poor prognosis in primary human breast cancer.
Neoplasms
Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study.
Neoplasms
Association of the 323/A3 surface glycoprotein with tumor characteristics and behavior in human breast cancer.
Neoplasms
Atypical teratoid/rhabdoid tumor of the CNS: cytopathology and immunohistochemistry of insulin-like growth factor-II, insulin-like growth factor receptor type 1, cathepsin D, and Ki-67.
Neoplasms
Basement membrane derived fibulin-1 and fibulin-5 function as angiogenesis inhibitors and suppress tumor growth.
Neoplasms
Bcl-2 protein expression and long-term survival in breast cancer.
Neoplasms
Benzophenone-1 and nonylphenol stimulated MCF-7 breast cancer growth by regulating cell cycle and metastasis-related genes via an estrogen receptor ?-dependent pathway.
Neoplasms
Berberine ameliorates intrahippocampal kainate-induced status epilepticus and consequent epileptogenic process in the rat: Underlying mechanisms.
Neoplasms
Biological and clinical relevance of the urokinase-type plasminogen activator (uPA) in breast cancer.
Neoplasms
Biological and clinical significance of cathepsin D in breast cancer metastasis.
Neoplasms
Biological and clinical significance of cathepsin D in breast cancer.
Neoplasms
Biological heterogeneity of ER-positive breast cancers in the post-menopausal population.
Neoplasms
Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure-Activity Relationship and Binding Mode Analysis.
Neoplasms
Bone hemangioendothelioma: an immunohistochemical study related to histological malignancy and proliferative activity (NORs).
Neoplasms
Breast-conserving therapy: proteases as risk factors in relation to survival after local relapse.
Neoplasms
CA 15-3 serum levels in patients with ductal breast carcinoma: relationship with clinicopathological parameters and tumor markers.
Neoplasms
Calcium-binding protein S100P and cancer: mechanisms and clinical relevance.
Neoplasms
Cancer biomarkers in atherosclerotic plaque: Evidenced from structural and proteomic analyses.
Neoplasms
Cancer with low cathepsin D levels is susceptible to V-ATPase inhibition.
Neoplasms
Capillary electrophoretic determination of cathepsin D activity using Oregon Green-labeled hemoglobin.
Neoplasms
Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes.
Neoplasms
Catalytically inactive human cathepsin D triggers fibroblast invasive growth.
Neoplasms
Cathepsin B activity in B16 melanoma cells: a possible marker for metastatic potential.
Neoplasms
Cathepsin B and Cathepsin D Expression in Follicular Adenomas and Carcinomas of the Thyroid Gland.
Neoplasms
Cathepsin B and cathepsin D expression in the progression of colorectal adenoma to carcinoma.
Neoplasms
Cathepsin B and D expression in squamous cell carcinoma.
Neoplasms
Cathepsin D activity and selectivity in the acidic conditions of a tumor microenvironment: Utilization in the development of a novel Cathepsin D substrate for simultaneous cancer diagnosis and therapy.
Neoplasms
Cathepsin D activity in colorectal cancer.
Neoplasms
Cathepsin D activity in human ovarian tissues and ovarian carcinoma.
Neoplasms
Cathepsin D acts as an essential mediator to promote malignancy of benign prostatic epithelium.
Neoplasms
Cathepsin D and chromogranin A as predictors of long term disease specific survival after radical prostatectomy for localized carcinoma of the prostate.
Neoplasms
Cathepsin D and epidermal growth factor receptor immunohistochemistry does not predict recurrence of prostate cancer in patients undergoing radical prostatectomy.
Neoplasms
Cathepsin D and its prognostic value in neuroepithelial brain tumors.
Neoplasms
Cathepsin D and PAI-1 expression in human head and neck cancer.
Neoplasms
Cathepsin D and prognosis in breast cancer.
Neoplasms
Cathepsin D as a potential prognostic marker for lung adenocarcinoma.
Neoplasms
Cathepsin D as a promising target for the discovery of novel anticancer agents.
Neoplasms
Cathepsin D assay in ovarian cancer: correlation with pathological features and receptors for oestrogen, progesterone and epidermal growth factor.
Neoplasms
Cathepsin D assay in primary breast cancer and lymph nodes: relationship with c-myc, c-erb-B-2 and int-2 oncogene amplification and node invasiveness.
Neoplasms
Cathepsin D concentration in breast cancer cytosols: correlation with disease-free interval and overall survival.
Neoplasms
Cathepsin D concentration in primary laryngeal cancer: correlation with clinico-pathological parameters, EGFR status and prognosis.
Neoplasms
Cathepsin D concentration in tumor cytosols improves the accuracy of prognostic evaluation of primary breast cancer.
Neoplasms
Cathepsin D content in colorectal cancer. Correlation with cathepsin D activity and other biological parameters: a preliminary report.
Neoplasms
Cathepsin D content in malignant tumours of corpus uteri.
Neoplasms
Cathepsin D cytosolic assay and immunohistochemical quantification in human prostate tumors.
Neoplasms
Cathepsin D detected by automated and quantitative immunohistochemistry in breast carcinomas: correlation with overall and disease free survival.
Neoplasms
Cathepsin D expression as a possible predictor of lymph node metastasis in submucosal colorectal cancer.
Neoplasms
Cathepsin D expression by cancer and stromal cells in breast cancer: an immunohistochemical study of 1348 cases.
Neoplasms
Cathepsin D expression in colorectal adenocarcinomas and adenomas.
Neoplasms
Cathepsin D Expression in Colorectal Cancer: From Proteomic Discovery through Validation Using Western Blotting, Immunohistochemistry, and Tissue Microarrays.
Neoplasms
Cathepsin D expression in early cutaneous malignant melanoma.
Neoplasms
Cathepsin D expression in human colorectal cancer: relationship with tumour type and tissue differentiation grade.
Neoplasms
Cathepsin D expression in renal cell cancer-clinical implications.
Neoplasms
Cathepsin D expression in skin metastasis of breast cancer.
Neoplasms
Cathepsin D expression levels in nongynecological solid tumors: clinical and therapeutic implications.
Neoplasms
Cathepsin D gene is controlled by a mixed promoter, and estrogens stimulate only TATA-dependent transcription in breast cancer cells.
Neoplasms
Cathepsin D immobilized capillary reactors for on-flow screening assays.
Neoplasms
Cathepsin D immunocytochemical assays in breast carcinomas: image analysis and correlation to prognostic factors.
Neoplasms
Cathepsin D immunoreactivity in ovarian cancer: correlation with prognostic factors.
Neoplasms
Cathepsin D immunostaining in paraffin-embedded breast cancer cells and macrophages: correlation with cytosolic assay.
Neoplasms
Cathepsin D in breast cancer tissue.
Neoplasms
Cathepsin D in breast cancer: from molecular and cellular biology to clinical applications.
Neoplasms
Cathepsin D in breast cancer: mechanisms and clinical applications, a 1999 overview.
Neoplasms
Cathepsin D in breast secretions from women with breast cancer.
Neoplasms
Cathepsin D in cancer metastasis: a protease and a ligand.
Neoplasms
Cathepsin D in host stromal cells is associated with more highly vascular and aggressive invasive breast carcinoma.
Neoplasms
Cathepsin D in host stromal cells, but not in tumor cells, is associated with aggressive behavior in node-negative breast cancer.
Neoplasms
Cathepsin D in invasive ductal NOS breast carcinoma as defined by immunohistochemistry. No correlation with survival at 5 years.
Neoplasms
Cathepsin D in invasive ductal NOS, medullary, lobular and mucinous breast carcinoma. An immunohistochemical study.
Neoplasms
Cathepsin D in laryngeal carcinoma. preliminary report.
Neoplasms
Cathepsin D in normal and neoplastic thyroid tissues.
Neoplasms
Cathepsin D in ovarian cancer: prognostic value and correlation with p53 expression and microvessel density.
Neoplasms
Cathepsin D in primary breast carcinoma: adverse prognosis is associated with expression of cathepsin D in stromal cells.
Neoplasms
Cathepsin D in primary squamous laryngeal tumors: correlation with clinico-pathological parameters and receptor status.
Neoplasms
Cathepsin D in the malignant progression of neoplastic diseases (review).
Neoplasms
Cathepsin D in the Tumor Microenvironment of Breast and Ovarian Cancers.
Neoplasms
Cathepsin D in tissue and serum of patients with squamous cell carcinoma of the head and neck.
Neoplasms
Cathepsin D inhibitors as potential therapeutics for breast cancer treatment: Molecular docking and bioevaluation against triple-negative and triple-positive breast cancers.
Neoplasms
Cathepsin D inhibits oxidative stress-induced cell death via activation of autophagy in cancer cells.
Neoplasms
Cathepsin D is a potential serum marker for poor prognosis in glioma patients.
Neoplasms
Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation.
Neoplasms
Cathepsin D levels in primary breast cancers: relationship with epidermal growth factor receptor, oestrogen receptor and axillary nodal status.
Neoplasms
Cathepsin D maturation and its stimulatory effect on metastasis are prevented by addition of KDEL retention signal.
Neoplasms
Cathepsin D non-proteolytically induces proliferation and migration in human omental microvascular endothelial cells via activation of the ERK1/2 and PI3K/AKT pathways.
Neoplasms
Cathepsin D overexpressed by cancer cells can enhance apoptosis-dependent chemo-sensitivity independently of its catalytic activity.
Neoplasms
Cathepsin D protein levels in colorectal tumors: divergent expression patterns suggest complex regulation and function.
Neoplasms
Cathepsin D serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging.
Neoplasms
Cathepsin D serum levels are not a valid serum marker in renal cell carcinoma.
Neoplasms
Cathepsin D serum mass concentrations in patients with hepatocellular carcinoma and/or liver cirrhosis.
Neoplasms
Cathepsin D specifically cleaves the chemokines macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, and SLC that are expressed in human breast cancer.
Neoplasms
Cathepsin D test helps identify breast cancers likely to recur.
Neoplasms
Cathepsin D versus other prognostic factors in breast cancer. Results and controversies of a multicenter study on 2575 cases.
Neoplasms
Cathepsin D, both a prognostic factor and a predictive factor for the effect of adjuvant tamoxifen in breast cancer. South Sweden Breast Cancer Group.
Neoplasms
Cathepsin D-related disease-free interval in pT1 primary breast carcinomas: a pilot study.
Neoplasms
Cathepsin D: an independent prognostic factor for metastasis of breast cancer.
Neoplasms
Cathepsin D: association between TN-stage and steroid receptor status of breast carcinoma.
Neoplasms
Cathepsin D: Autoantibody profiling as a diagnostic marker for cancers.
Neoplasms
Cathepsin D: newly discovered functions of a long-standing aspartic protease in cancer and apoptosis.
Neoplasms
Cathepsin-d activity levels in colorectal-cancer - correlation with cathepsin-B and cathepsin-L and other biological and clinical-parameters.
Neoplasms
Cathepsin-D and c-erb-B 2 have an additive prognostic value for breast cancer patients.
Neoplasms
Cathepsin-d in breast carcinomas - the role of the stromal cell component.
Neoplasms
Cathepsin-D, urokinase plasminogen activator and type-1 plasminogen activator inhibitor in early breast cancer: an immunohistochemical study of prognostic value and relations to tenascin-C and other factors.
Neoplasms
Cathepsins D, B, and L in malignant human lung tissue.
Neoplasms
Cathepsins in basal cell carcinomas: activity, immunoreactivity and mRNA staining of cathepsins B, D, H and L.
Neoplasms
CD31 quantitative immunocytochemical assays in breast carcinomas. Correlation with current prognostic factors.
Neoplasms
CD44 expression in colorectal cancer. An immunohistochemical study including correlation with cathepsin D immunoreactivity and some tumour clinicopathological features.
Neoplasms
Cells producing cathepsins D, B, and L in human breast carcinoma and their association with prognosis.
Neoplasms
Cellular distribution of cathepsin D in childhood tumors.
Neoplasms
Cellular localisation by in situ hybridisation of cathepsin D, stromelysin 3, and urokinase plasminogen activator RNAs in breast cancer.
Neoplasms
Cervical lymph node status and survival in laryngeal carcinoma: prognostic factors.
Neoplasms
Changes induced in astrocyte cathepsin D by cytokines and leupeptin.
Neoplasms
Characterization of purified cathepsin D from malignant human breast tissue.
Neoplasms
Characterization of very acidic phagosomes in breast cancer cells and their association with invasion.
Neoplasms
Clinical prognostic factors and expression of cathepsin D in endometrioid adenocarcinoma.
Neoplasms
Clinical relevance of biologic factors in male breast cancer.
Neoplasms
Clinical relevance of urokinase-type plasminogen activator, its receptor and inhibitor type 1 in ovarian cancer.
Neoplasms
Clinical significance of cathepsin D assay in breast cancer tissues.
Neoplasms
Clinical significance of cathepsin D concentration in tumor cytosol of primary breast cancer.
Neoplasms
Clinical significance of cathepsin D in primary ovarian cancer.
Neoplasms
Clinicopathological correlation between expression of PTHrP receptor and various prognostic factors in breast cancer without axillary lymph node metastasis.
Neoplasms
Clinicopathological significance of cathepsin D expression in gastric adenocarcinoma.
Neoplasms
Clinicopathological significance of cathepsin D expression in non-small cell lung cancer is conditional on apoptosis-associated protein phenotype: an immunohistochemistry study.
Neoplasms
Clinicopathological study of the expression of hsp27, pS2, cathepsin D and metallothionein in primary invasive breast cancer.
Neoplasms
Co-expression of thymidine kinase and cathepsin D in 200 primary breast carcinomas.
Neoplasms
Collagen-based co-culture for invasive study on cancer cells-fibroblasts interaction.
Neoplasms
Comparative autoantibody profiling before and after appearance of malignance: Identification of anti-cathepsin D autoantibody as a promising diagnostic marker for lung cancer.
Neoplasms
Comparative biochemical and immunohistochemical studies on the cathepsin D content of human breast cancer.
Neoplasms
Comparative quantitative immunohistochemical and immunoradiometric determinations of cathepsin D in endometrial adenocarcinoma: predictors of tumor aggressiveness.
Neoplasms
Comparative transcriptional analysis reveals distinct expression patterns of channel catfish genes after the first infection and re-infection with Aeromonas hydrophila.
Neoplasms
Comparison of hepatic cathepsin D activity in response to tumor growth and to caloric restriction in mice.
Neoplasms
Comparison of proteinase activities in squamous cell carcinoma, basal cell epithelioma, and seborrheic keratosis.
Neoplasms
Comparison of the metastasis-inducing protein S100A4 (p9ka) with other prognostic markers in human breast cancer.
Neoplasms
Comparison of the tumor associated proteases cathepsin D (CATH D) and urokinase-type plasminogen activator (uPA) in cytosols of human breast cancer patients.
Neoplasms
Complex modulation of peptidolytic activity of cathepsin D by sphingolipids.
Neoplasms
Controversies in the treatment of ductal carcinoma in situ.
Neoplasms
Correlation between cathepsin D expression and p53 protein nuclear accumulation in oesophageal squamous cell carcinoma.
Neoplasms
Correlation between laminin and cathepsin D expressions in breast carcinoma.
Neoplasms
Correlation between mannose-6-phosphate/IGFII receptor and cathepsin D RNA levels by in situ hybridization in benign and malignant mammary tumors.
Neoplasms
Correlation between pS2 protein positivity, steroid receptor status and other prognostic factors in breast cancer.
Neoplasms
Correlation of cytosolic concentrations of ER, PS2, Cath-D, TPS, TK and cAMP in primary breast carcinomas.
Neoplasms
Correlation of tumor cytosol cathepsin D with differentiation and invasiveness of endometrial adenocarcinoma.
Neoplasms
CORRELATIONSHIP OF CATHEPSIN D AND TOPOISOMERASE II ALPHA WITH NUCLEAR GRADING IN BREAST CANCERS.
Neoplasms
Cyanobacterial peptides as a prototype for the design of cathepsin D inhibitors.
Neoplasms
Cyclin D1 in human neuroblastic tumors recapitulates its developmental expression: An immunohistochemical study.
Neoplasms
Cytosol cathepsin D in Thai women with breast cancer.
Neoplasms
Cytosol cathepsin-D content and proliferative activity of human breast cancer. The Comitato Italiano per il Controllo di Qualita del Laboratorio in Oncologia.
Neoplasms
Decreased secretion of Cathepsin D in breast cancer in vivo by tamoxifen: mediated by the mannose-6-phosphate/IGF-II receptor?
Neoplasms
Defective acidification of intracellular organelles results in aberrant secretion of cathepsin D in cancer cells.
Neoplasms
Depletion of Procathepsin D Gene Expression by RNA Interference: A Potential Therapeutic Target for Breast Cancer.
Neoplasms
Design, synthesis, and bioactivities of tasiamide B derivatives as cathepsin D inhibitors.
Neoplasms
Detection of isolated tumor cells in bone marrow is an independent prognostic factor in breast cancer.
Neoplasms
Detection of oral squamous cell carcinoma metastasis with cathepsin D: An immunohistochemical approach.
Neoplasms
Development and characterization of a tamoxifen-resistant breast carcinoma xenograft.
Neoplasms
Diagnostic values of serum cathepsin B and D in patients with nasopharyngeal carcinoma.
Neoplasms
Differential expression levels of urokinase-type plasminogen activator and cathepsin D in locally advanced laryngeal squamous cell carcinoma: clinical implications.
Neoplasms
Differentiation and cathepsin D expression in human oral tumors.
Neoplasms
Digital image-analysis of nuclear morphometry, DNA-ploidy and AgNORs in breast-carcinoma cell imprints.
Neoplasms
Dipeptide mimic oligomer transporter mediates intracellular delivery of Cathepsin D inhibitors: A potential target for cancer therapy.
Neoplasms
Dissociated overexpression of cathepsin D and estrogen receptor alpha in preinvasive mammary tumors.
Neoplasms
Distant metastasis after radical treatment of breast cancer: risk factors and their prognostic relevance in 378 consecutive patients.
Neoplasms
Do American oncologists know how to use prognostic variables for patients with newly diagnosed primary breast cancer?
Neoplasms
Down-regulation of LAPTM5 in human cancer cells.
Neoplasms
Effect of altered thyroid status on lysosomal enzymes and thymidylate synthetase activity in tumors and livers of host animals.
Neoplasms
Effect of fenhexamid and cyprodinil on the expression of cell cycle- and metastasis-related genes via an estrogen receptor-dependent pathway in cellular and xenografted ovarian cancer models.
Neoplasms
Effect of procathepsin D and its activation peptide on prostate cancer cells.
Neoplasms
Effect of tumor size on the association between ps2 and cathepsin-d in primary breast-cancer.
Neoplasms
Effects of cathepsin D inhibitor from Vicia sativa L. seed hulls on human skin fibroblasts and breast cancer cells (in vitro studies).
Neoplasms
Elevated activity and increased mannose-6-phosphate in the carbohydrate moiety of cathepsin D from human hepatoma.
Neoplasms
Elevated levels of pro-cathepsin-d in the plasma of breast-cancer patients.
Neoplasms
Elucidating the function of secreted maspin: inhibiting cathepsin D-mediated matrix degradation.
Neoplasms
Endocytosis of pro-cathepsin D into breast cancer cells is mostly independent of mannose-6-phosphate receptors.
Neoplasms
Endometrial adenocarcinoma of endometrioid subtype with squamous differentiation: an immunohistochemical study of MIB-1 (ki-67 paraffin), cathepsin D, and C-erbB-2 protein (p185).
Neoplasms
Endosomal proteolysis of insulin-like growth factor-I at its C-terminal D-domain by cathepsin B.
Neoplasms
Enzymatically active cathepsin D sensitizes breast carcinoma cells to TRAIL.
Neoplasms
Enzyme-linked immunosorbent assay of HER-2/neu gene product (p185) in breast cancer: its correlation with sex steroid receptors, cathepsin D and histologic grades.
Neoplasms
Estrogen receptors and cathepsin D in human thyroid tissue.
Neoplasms
Estrogen regulated proteases and antiproteases in ovarian and breast cancer cells.
Neoplasms
Evaluation of cathepsin D and epidermal growth factor receptor in prostate carcinoma.
Neoplasms
Evaluation of cathepsin D as prognostic predictor in breast cancer.
Neoplasms
Evaluation of prognostic factors in male breast cancer.
Neoplasms
Evaluation of the prognostic significance of cathepsin D, epidermal growth factor receptor, and c-erbB-2 in early cervical squamous cell carcinoma. An immunohistochemical study.
Neoplasms
Evaluation of the prognostic significance of nm23/NDP kinase and cathepsin D in anal carcinomas. An immunohistochemical study.
Neoplasms
Expression and Localization of Cathepsins B, D and G in Cancer Stem Cells in Liver Metastasis From Colon Adenocarcinoma.
Neoplasms
Expression and posttranslational fate of cathepsin D in HT-29 tumor cells depend on their enterocytic differentiation state.
Neoplasms
Expression and prognostic significance of apolipoprotein D in breast cancer.
Neoplasms
Expression of adhesion factors and degrading proteins in primary and secondary glioblastomas and their precursor tumors.
Neoplasms
Expression of cathepsin D and B in invasion and metastasis of squamous cell carcinoma.
Neoplasms
Expression of cathepsin D and E-cadherin in primary laryngeal cancers correlation with neck lymph node involvement.
Neoplasms
Expression of cathepsin D and pS2 in imprint smears of breast carcinoma.
Neoplasms
Expression of cathepsin D during the progression of human gliomas.
Neoplasms
Expression of cathepsin D in bladder carcinoma: correlation with pathological features and serum cystatin C levels.
Neoplasms
Expression of cathepsin D in head and neck cancer.
Neoplasms
Expression of cathepsin D in human astrocytic neoplasias.
Neoplasms
Expression of cathepsin D in malignant and in the corresponding non-malignant node-negative laryngeal samples: correlation with receptors for androgen, glucocorticoid, oestrogen and progesterone.
Neoplasms
Expression of cathepsin D in primary and metastatic human melanoma and dysplastic nevi.
Neoplasms
Expression of cathepsin D in transitional cell bladder tumours.
Neoplasms
Expression of cathepsin D in urothelial carcinoma of the urinary bladder: an immunohistochemical study including correlations with extracellular matrix components, CD44, p53, Rb, c-erbB-2 and the proliferation indices.
Neoplasms
Expression of E-cadherin, beta-catenin, cathepsin D, gelatinases and their inhibitors in invasive ductal breast carcinomas.
Neoplasms
Expression of extracellular matrix-degrading proteins in classic, atypical, and anaplastic meningiomas.
Neoplasms
Expression of genes that contribute to proliferative and metastatic ability in breast cancer resected during various menstrual phases.
Neoplasms
Expression of human mammaglobin as a marker of bone marrow micrometastasis in breast cancer.
Neoplasms
Expression of hypoxia-inducible factor 1alpha and cathepsin D in pituitary adenomas.
Neoplasms
Expression of ps2 and cathepsin-d in breast-cancer.
Neoplasms
Expression of pS2, c-erbB-2, and cathepsin D during the menstrual cycle in human breast cancers.
Neoplasms
Expression of syndecan-1 and cathepsins D and K in advanced esophageal squamous cell carcinoma.
Neoplasms
Expression, localization, and thyrotropin regulation of cathepsin D in human thyroid tissues.
Neoplasms
Expressions of chromogranin A and cathepsin D in human primary hepatocellular carcinoma.
Neoplasms
Fatty acid synthase (FAS) predictive strength in poorly differentiated early breast carcinomas.
Neoplasms
Fibroblasts capture cathepsin D secreted by breast cancer cells: possible role in the regulation of the invasive process.
Neoplasms
Flow cytometry analysis of apoptotic progression and expression analysis of four apoptosis-related genes in Penaeus vannamei in response to white spot syndrome virus infection.
Neoplasms
Fluctuation of HER2 expression in breast carcinomas during the menstrual cycle.
Neoplasms
Gastric carcinoma: expression of c-erbB-2/neu oncoprotein, epidermal growth factor receptor, cathepsin D, progesterone receptor and tumor associated glycoprotein-72 in different histological types.
Neoplasms
Genes associated with the tumour microenvironment are differentially expressed in cured versus primary chemotherapy-refractory diffuse large B-cell lymphoma.
Neoplasms
Giant-cell tumors of bone and progesterone receptors.
Neoplasms
Glycoprotein CD44 expression in colorectal neoplasms. An immuno-histochemical study including correlation with cathepsin D, extracellular matrix components, p53, Rb, bcl-2, c-erbB-2, EGFR and proliferation indices.
Neoplasms
Glycoproteomic analysis of bronchoalveolar lavage (BAL) fluid identifies tumor-associated glycoproteins from lung adenocarcinoma.
Neoplasms
Graphene Oxide-Based Targeting of Extracellular Cathepsin D and Cathepsin L As A Novel Anti-Metastatic Enzyme Cancer Therapy.
Neoplasms
Heat shock cognate 70 protein secretion as a new growth arrest signal for cancer cells.
Neoplasms
High expression of the trefoil protein TFF1 in interval breast cancers.
Neoplasms
High levels of cathepsin B predict poor outcome in patients with breast cancer.
Neoplasms
High levels of cathepsin D and cystatin B are associated with increased risk of coronary events.
Neoplasms
High throughput screening of meningioma biomarkers using a tissue microarray.
Neoplasms
High yield synthesis and characterization of phosphorylated recombinant human procathepsin D expressed in mammalian cells.
Neoplasms
Histologic grade and p53 immunoreaction as indicators of early recurrence of node-negative breast cancer.
Neoplasms
Hormonal regulation of cathepsin D following transfection of the estrogen or progesterone receptor into three sex steroid hormone resistant cancer cell lines.
Neoplasms
Host cathepsin D response to tumor in the normal and pepstatin-treated mouse.
Neoplasms
How to target estrogen receptor-negative breast cancer?
Neoplasms
Human giant cell tumors of the bone (osteoclastomas) are estrogen target cells.
Neoplasms
Human telomerase reverse transcriptase (hTERT) promotes cancer invasion by modulating cathepsin D via early growth response (EGR)-1.
Neoplasms
Identification and structure-activity relationship studies of small molecule inhibitors of the human cathepsin D.
Neoplasms
Identification of a novel aspartic-like protease differentially expressed in human breast cancer cell lines.
Neoplasms
Identification of a novel estrogen receptor-alpha variant and its upstream splicing regulator.
Neoplasms
Identification of breast cancer metastasis-associated proteins in an isogenic tumor metastasis model using two-dimensional gel electrophoresis and liquid chromatography-ion trap-mass spectrometry.
Neoplasms
Immuno-histochemical evaluation of Cathepsin D in malignant salivary gland carcinomas.
Neoplasms
Immunocytochemical localization of Cathepsin D and CA 125 in ovarian cancer.
Neoplasms
Immunohistochemical analysis and prognostic value of cathepsin D determination in laryngeal squamous cell carcinoma.
Neoplasms
Immunohistochemical analysis of cathepsin D in prostate carcinoma.
Neoplasms
Immunohistochemical analysis of cathepsins D, B, and L in human breast cancer.
Neoplasms
Immunohistochemical analysis of desmoid tumours.
Neoplasms
Immunohistochemical and immunoradiometric evaluations of total cathepsin D in human larynx.
Neoplasms
Immunohistochemical and other features of breast carcinomas presenting clinically compared with those detected by cancer screening.
Neoplasms
Immunohistochemical detection of cathepsin D in low grade breast invasive cancer.
Neoplasms
Immunohistochemical detection of cathepsin D in T2N0M0 breast carcinoma.
Neoplasms
Immunohistochemical detection of cathepsin-d expression in prostate-cancer.
Neoplasms
Immunohistochemical detection of nm23/NDP kinase and cathepsin D in medullary carcinomas of the thyroid gland.
Neoplasms
Immunohistochemical evaluation of cathepsin D expression in colorectal cancer.
Neoplasms
Immunohistochemical evaluation of cathepsin D expression in colorectal tumours: a correlation with extracellular matrix components, p53, pRb, bcl-2, c-erbB-2, EGFR and proliferation indices.
Neoplasms
Immunohistochemical evaluation of tissue-specific proteolytic enzymes in adenomas containing foci of early carcinoma: correlations with cathepsin D expression and other malignant features.
Neoplasms
Immunohistochemical expression of cathepsin D in laryngeal epithelial lesions: correlation with CD44 expression, p53 and Rb status and proliferation associated indices.
Neoplasms
Immunohistochemical expression of cathepsin D in meningiomas.
Neoplasms
Immunohistochemical Expression of Cathepsin D in Primary and Recurrent Squamous Cell Carcinoma.
Neoplasms
Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: their prognostic value and role in tumour invasion and progression.
Neoplasms
Immunohistochemical localization of cathepsin D in colorectal tumors.
Neoplasms
Immunohistochemical markers of prolonged survival in small cell carcinoma of the lung. An immunohistochemical study.
Neoplasms
Immunohistochemical molecular markers as predictors of curability of endoscopically resected submucosal colorectal cancer.
Neoplasms
Immunohistochemical p53 overexpression correlated to c-erbB-2 and cathepsin D proteins in colorectal cancer.
Neoplasms
Immunohistochemical studies of proliferating cell nuclear antigen and cathepsin D in transitional cell carcinoma of the urinary bladder.
Neoplasms
Immunohistochemical visualisation of cathepsin-D expression in breast cancer.
Neoplasms
Immunolocalization of cathepsin D in normal and neoplastic human tissues.
Neoplasms
Immunolocalization of cathepsin D in the human central nervous system and central nervous system neoplasms.
Neoplasms
Immunoradiometric and immunohistochemical analysis of Cathepsin D in ovarian cancer: lack of association with clinical outcome.
Neoplasms
Immunoradiometric assay of pro-cathepsin D in breast cancer cytosol: relative prognostic value versus total cathepsin D.
Neoplasms
Immunoradiometric detection of pS2 and total cathepsin D in primary breast cancer biopsies: their correlation with steroid receptors.
Neoplasms
Immunostaining of cathepsin D in breast cancer: quantification by computerised image analysis and correlation with cytosolic assay.
Neoplasms
Immunostaining of cathepsin-d in nonsmall cell lung-cancer - correlations with morphological and biological parameters.
Neoplasms
Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies.
Neoplasms
In vivo stimulation by tamoxifen of cathepsin D RNA level in breast cancer.
Neoplasms
Incorporation of histone derived recombinant protein for enhanced disassembly of core-membrane structured liposomal nanoparticles for efficient siRNA delivery.
Neoplasms
Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells.
Neoplasms
Increased apoptosis in cancer cells in vitro and in vivo by ceramides in transferrin-modified liposomes.
Neoplasms
Increased cathepsin D protein expression is a biomarker for osteosarcomas, pulmonary metastases and other bone malignancies.
Neoplasms
Increased secretion, altered processing, and glycosylation of pro-cathepsin D in human mammary cancer cells.
Neoplasms
Induction of cathepsin D protein during estrogen carcinogenesis: possible role in estrogen-mediated kidney tubular cell damage.
Neoplasms
Inflammatory cytokines increase extracellular procathepsin D in permanent and primary endothelial cell cultures.
Neoplasms
Influence of cathepsin D expression in lung adenocarcinoma on prognosis: possible importance of its expression in tumor cells and stromal cells, and its intracellular polarization in tumor cells.
Neoplasms
Influence of quercetin on B16 melanotic melanoma growth in C57BL/6 mice and on activity of some acid hydrolases in melanoma tissue.
Neoplasms
Influence of Ukrain and cyclophosphamide administration on HA-1 murine hepatoma and LS lymphoma on aspartic proteinase cathepsin D.
Neoplasms
Inhibition of breast cancer growth by suramin.
Neoplasms
Inhibition of Cathepsin D (CTSD) enhances radiosensitivity of glioblastoma cells by attenuating autophagy.
Neoplasms
Inhibitors of proteases as anticancer drugs.
Neoplasms
Inhibitory Effects of ?- and ?-Tocopherols on Estrogen-Stimulated Breast Cancer In Vitro and In Vivo.
Neoplasms
Insulin-like growth factor binding protein (IGFBP) proteases: functional regulators of cell growth.
Neoplasms
Invasion marker PAI-1 remains a strong prognostic factor after long-term follow-up both for primary breast cancer and following first relapse.
Neoplasms
Invasion of ras-transformed breast epithelial cells depends on the proteolytic activity of cysteine and aspartic proteinases.
Neoplasms
Involvement of cathepsin D in chemotherapy-induced cytochrome c release, caspase activation, and cell death.
Neoplasms
Keeping data continuous when analyzing the prognostic impact of a tumor marker: an example with cathepsin D in breast cancer.
Neoplasms
Ki-67 staining in benign, borderline, malignant primary and metastatic ovarian tumors: correlation with steroid receptors, epidermal-growth-factor receptor and cathepsin D.
Neoplasms
Lack of prognostic value of cathepsin D levels for predicting short term outcomes of breast cancer patients.
Neoplasms
Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease.
Neoplasms
Localization of nuclear cathepsin L and its association with disease progression and poor outcome in colorectal cancer.
Neoplasms
Long-term follow-up confirms prognostic impact of PAI-1 and cathepsin D and L in primary breast cancer.
Neoplasms
Low cathepsin D and low plasminogen activator type 1 inhibitor in tumor cytosols defines a group of node negative breast cancer patients with low risk of recurrence.
Neoplasms
Low levels of basic fibroblast growth factor (bFGF) are associated with a poor prognosis in human breast carcinoma.
Neoplasms
Lowering endogenous cathepsin D abundance results in ROS accumulation and cell senescence.
Neoplasms
Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis.
Neoplasms
Lysosome-mitochondria-mediated apoptosis specifically evoked in cancer cells induced by gold nanorods.
Neoplasms
Male breast cancer: clinico-pathological features, immunocytochemical characteristics and prognosis.
Neoplasms
Mammary serum antigen (MSA), Ca 549, CA 15-3 and CEA in breast cancer preoperative sensitivity and correlation to prognostic factors.
Neoplasms
Markers of function and proliferation in non-invasive and invasive bi- and plurihormonal adenomas of patients with acromegaly: an immunohistochemical study.
Neoplasms
Matrix metalloproteinase expression in human breast cancer: an immunohistochemical study including correlation with cathepsin D, type IV collagen, laminin, fibronectin, EGFR, c-erbB-2 oncoprotein, p53, steroid receptors status and proliferative indices.
Neoplasms
Matrix metalloproteinase-9 interplays with the IGFBP2-IGFII complex to promote cell growth and motility in astrocytomas.
Neoplasms
May cathepsin D immunoreactivity be used as a prognostic factor in endometrial carcinomas? A comparative immunohistochemical study.
Neoplasms
Mechanisms and kinetics of procathepsin D activation.
Neoplasms
Melatonin improves periodontitis-induced kidney damages by decreasing inflammatory stress and apoptosis in rats.
Neoplasms
Mesenchymal stem cell homing towards cancer cells is increased by enzyme activity of cathepsin D.
Neoplasms
Micro-lymph node metastasis and its correlation with cathepsin D expression in early gastric cancer.
Neoplasms
Mis-sorting of procathepsin D in metastogenic tumor cells is not due to impaired synthesis of the phosphomannosyl signal.
Neoplasms
Missense polymorphism (C/T224) in the human cathepsin D pro-fragment determined by polymerase chain reaction--single strand conformational polymorphism analysis and possible consequences in cancer cells.
Neoplasms
Mitogenic function of human procathepsin D: the role of the propeptide.
Neoplasms
Modulation of inflammatory markers by the ethanolic extract of Leucas aspera in adjuvant arthritis.
Neoplasms
Modulation of proliferation and chemosensitivity by procathepsin D and its peptides in ovarian cancer.
Neoplasms
MUC1 and cathepsin D expression in early colorectal carcinoma showing V type pit pattern.
Neoplasms
Multiparametric prognostic evaluation of biological factors in primary breast cancer.
Neoplasms
Mutual predictive value of c-erbB-2 overexpression and various prognostic factors in ductal invasive breast carcinoma.
Neoplasms
Neither creatinine nor cystatin C-estimated glomerular filtration rate is optimal in oncology patients treated with targeted agents.
Neoplasms
New cathepsin d inhibitors with hydroxyethylamine isosteres: preparation and characterization.
Neoplasms
Nm23 and cathepsin D expression in laryngeal carcinomas.
Neoplasms
nm23--relationship to the metastatic potential of breast carcinoma cell lines, primary human xenografts, and lymph node negative breast carcinoma patients.
Neoplasms
Node negative breast carcinoma: hyperprolactinemia and/or overexpression of p53 as an independent predictor of poor prognosis compared to newer and established prognosticators.
Neoplasms
Novel blood biomarkers of human urinary bladder cancer.
Neoplasms
Novel proteomic strategy reveal combined alpha1 antitrypsin and cathepsin D as biomarkers for colorectal cancer early screening.
Neoplasms
Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells.
Neoplasms
Oestrogens, proteases and breast cancer. From cell lines to clinical applications.
Neoplasms
Olfactomedin 4 Suppresses Prostate Cancer Cell Growth and Metastasis via Negative Interaction with Cathepsin D and SDF-1.
Neoplasms
Oral granular cell myoblastoma: an immunohistochemical study.
Neoplasms
Overexpression and hormonal regulation of pro-cathepsin D in mammary and endometrial cancer.
Neoplasms
Overexpression Cathepsin D Contributes to Perineural Invasion of Salivary Adenoid Cystic Carcinoma.
Neoplasms
Overexpression in colorectal carcinoma of two lysosomal enzymes, CLN2 and CLN1, involved in neuronal ceroid lipofuscinosis.
Neoplasms
Overexpression of both catalytically active and -inactive cathepsin D by cancer cells enhances apoptosis-dependent chemo-sensitivity.
Neoplasms
Overexpression of cathepsin D in malignant melanoma.
Neoplasms
Overview on human breast cancer with focus on prognostic and predictive factors with special attention on the tumour suppressor gene p53.
Neoplasms
P53 and cathepsin-d are independent of established prognostic factors in breast-cancer.
Neoplasms
p53 associated with cathepsin D in primary breast cancer.
Neoplasms
p53 quantitative immunocytochemical analysis in breast carcinomas.
Neoplasms
Pathophysiological functions of cathepsin D: Targeting its catalytic activity versus its protein binding activity?
Neoplasms
Pepstatin, an inhibitor of acid kininogenases and ascites retardant in neoplastic disease.
Neoplasms
Periodontitis exacerbates the renal degenerative effects of obesity in rats.
Neoplasms
Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity.
Neoplasms
Predicting response to neoadjuvant chemotherapy in patients with cervical carcinoma: can we do without any longer?
Neoplasms
Prediction of the extent of prostate cancer by the combined use of systematic biopsy and serum level of cathepsin D.
Neoplasms
Preparation of a cathepsin D sensitive near-infrared fluorescence probe for imaging.
Neoplasms
Probing the cathepsin D using a BODIPY FL-pepstatin A: applications in fluorescence polarization and microscopy.
Neoplasms
Procathepsin d as a tumor marker, anti-cancer drug or screening agent.
Neoplasms
Prognostic evaluation of metallothionein expression in human colorectal neoplasms.
Neoplasms
Prognostic evaluation of oestrogen-regulated protein immunoreactivity in ductal invasive (NOS) breast cancer.
Neoplasms
Prognostic impact of cathepsin D and c-erbB-2 oncoprotein in a subgroup of node-negative breast cancer patients with low histological grade tumors.
Neoplasms
Prognostic impact of tumor biological factors on survival in node-negative breast cancer.
Neoplasms
Prognostic indicators for early-stage breast-carcinoma .2. Value of cathepsin-d expression, detected by immunocytochemistry - a multiparametric study.
Neoplasms
Prognostic indicators in node-negative early stage breast cancer.
Neoplasms
Prognostic markers in pheochromocytoma.
Neoplasms
Prognostic molecular markers in early breast cancer.
Neoplasms
Prognostic relevance of cathepsin D detection in micrometastatic cells in the bone marrow of patients with primary breast cancer.
Neoplasms
Prognostic relevance of cathepsin D versus oestrogen receptors in node negative breast cancers.
Neoplasms
Prognostic significance of angiogenesis and immunoreactivity of cathepsin D and type IV collagen in high-grade stage T1 primary bladder cancer.
Neoplasms
Prognostic significance of immunohistochemical analysis of cathepsin D in low-stage breast cancer.
Neoplasms
Prognostic significance of the estrogen-regulated protein, cathepsin D, in breast cancer. An immunohistochemical study.
Neoplasms
Prognostic significance of the metastasis-inducing protein S100A4 (p9Ka) in human breast cancer.
Neoplasms
Prognostic value of cathepsin D expression and association with histomorphological subtypes in breast cancer.
Neoplasms
Prognostic value of Cathepsin D expression in breast cancer: immunohistochemical assessment and correlation with radiometric assay.
Neoplasms
Prognostic value of cathepsin D in breast cancer: comparison of immunohistochemical and immunoradiometric detection methods.
Neoplasms
Prognostic value of cytosolyc cathepsin D content in resectable gastric cancer.
Neoplasms
Prognostic value of p53 expression in early-stage breast-carcinoma compared with tumor angiogenesis, epidermal growth-factor receptor, C-erbb-2, cathepsin-d, DNA-ploidy, parameters of cell-kinetics and conventional features.
Neoplasms
Prognostic value of plasminogen activator inhibitor-1 in head and neck squamous cell carcinoma.
Neoplasms
Prognostic value of PS2 and cathepsin D in 710 human primary breast tumors: multivariate analysis.
Neoplasms
Prognostic value of the quantitative measurement of the oncoprotein p185(Her-2/neu) in a group of patients with breast cancer and positive node involvement.
Neoplasms
Prognostic value of total cathepsin D in breast tumors. A possible role in selection of chemoresistant patients.
Neoplasms
Prospective evaluation of prognostic factors in operable breast cancer.
Neoplasms
Proteases associated with gynecological tumors.
Neoplasms
Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry.
Neoplasms
Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment.
Neoplasms
Proteomic analysis of differential protein expression in a human hepatoma revertant cell line by using an improved two-dimensional electrophoresis procedure combined with matrix assisted laser desorption/ionization-time of flight-mass spectrometry.
Neoplasms
Proteomic approach toward molecular backgrounds of drug resistance of osteosarcoma cells in spheroid culture system.
Neoplasms
Proteomic characterization of nipple aspirate fluid: identification of potential biomarkers of breast cancer.
Neoplasms
Proteomic profiling of cancer of the gingivo-buccal complex: Identification of new differentially expressed markers.
Neoplasms
Proteomic study of malignant pleural mesothelioma by laser microdissection and two-dimensional difference gel electrophoresis identified cathepsin D as a novel candidate for a differential diagnosis biomarker.
Neoplasms
Proteomic-based biosignatures in breast cancer classification and prediction of therapeutic response.
Neoplasms
Proteomics-based Strategy to Delineate the Molecular Mechanisms of RhoGDI2-induced Metastasis and Drug Resistance in Gastric Cancer.
Neoplasms
Purification and properties of cathepsin D from rat Yoshida ascites hepatoma AH-130.
Neoplasms
Quantification of cathepsin D in plasma of patients with malignant melanoma.
Neoplasms
Quantitative analyses of epidermal growth factor receptors, HER-2/neu oncoprotein and cathepsin D in nonmalignant and malignant uteri.
Neoplasms
Quantitative analysis of p185(HER-2/neu) protein in breast cancer and its association with other prognostic factors.
Neoplasms
Quantitative immunocytochemical assays of P-glycoprotein in breast carcinomas: correlation to messenger RNA expression and to immunohistochemical prognostic indicators.
Neoplasms
Quantitative immunohistochemical determination of cathepsin D levels in prostatic carcinoma biopsies. Correlation with tumor grade, stage, PSA level, and DNA ploidy status.
Neoplasms
Quantitative immunohistochemical determination of cathepsin-D and its relation with other variables.
Neoplasms
Quantitative Proteomics Reveals Cellular Off-Targets of a DDR1 Inhibitor.
Neoplasms
Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma.
Neoplasms
Reevaluating cathepsin D as a biomarker for breast cancer: serum activity levels versus histopathology.
Neoplasms
Regulation of metastasis-related gene expression by p53: a potential clinical implication.
Neoplasms
Regulation, clinical and biological significance of cathepsin D in breast cancer.
Neoplasms
Relation between cathepsin D expression and other prognostic factors in breast carcinomas.
Neoplasms
Relation of cathepsin D level to the estrogen receptor in human breast cancer.
Neoplasms
Relationship between cathepsin D and other pathological and biological parameters in 1752 patients with primary breast cancer.
Neoplasms
Relationship between cathepsin D, urokinase, and plasminogen activator inhibitors in malignant vs benign breast tumours.
Neoplasms
Relationship between cathepsin-D and other prognostic factors in human breast cancer.
Neoplasms
Relationship of tumoral hyaluronic acid and cathepsin D contents with histological type of gastric carcinoma.
Neoplasms
Release of the aspartyl protease cathepsin D is associated with and facilitates human breast cancer cell invasion.
Neoplasms
Ribozyme-targeting procathepsin D and its effect on invasion and growth of breast cancer cells: an implication in breast cancer therapy.
Neoplasms
Risk-group discrimination in node-negative breast cancer using invasion and proliferation markers: 6-year median follow-up.
Neoplasms
Role for HER2/neu and HER3 in fulvestrant-resistant breast cancer.
Neoplasms
Secretion of a latent, acid activatable cathepsin L precursor by human non-small cell lung cancer cell lines.
Neoplasms
Serum levels of Hemorphin-7 peptides in patients with breast cancer.
Neoplasms
Significance of cathepsin-D expression in uterine tumours.
Neoplasms
Significance of estrogen receptors and cathepsin D tissue detection in gastric adenocarcinoma.
Neoplasms
Significance of the tumor protease Cathepsin D for the biology of breast cancer.
Neoplasms
Similarities and differences in the biogenesis, processing and lysosomal targeting between zebrafish and human pro-Cathepsin D: functional implications.
Neoplasms
Single- and double-headed chemical probes for detection of active cathepsin D in a cancer cell proteome.
Neoplasms
Skeletal muscle mRNA levels for cathepsin B, but not components of the ubiquitin-proteasome pathway, are increased in patients with lung cancer referred for thoracotomy.
Neoplasms
Specific oncological contribution of cathepsin D and pS2 in human breast cancer: their relationship with TNM status, estradiol receptors, epidermal growth factor receptor and neu amplification.
Neoplasms
Splenic littoral cell haemangioendothelioma: a new low-grade variant of malignant littoral cell tumour.
Neoplasms
Squamous cell carcinoma of the vulva. Expression of tumor proteases cathepsin-D and pro-cathepsin-L.
Neoplasms
Stefins and lysosomal cathepsins B, L and D in human breast carcinoma.
Neoplasms
Steroid receptors, pS2 and cathepsin D in early clinically node-negative breast cancer.
Neoplasms
Stromal cell cathepsin D expression and long-term survival in breast cancer.
Neoplasms
Structural differences in the cell binding region of human fibronectin molecules isolated from cultured normal and tumor-derived human cells.
Neoplasms
Structure-Activity Relationships of JMV4463, a Vectorized Cathepsin?D Inhibitor with Antiproliferative Properties: The Unique Role of the AMPA-Based Vector.
Neoplasms
Study of the frequencies of CYP1A1 gene polymorphisms and glutathione S-transferase mu1 gene in primary breast cancers: an update with an additional 114 cases.
Neoplasms
Tamoxifen treatment increases the concentration of 52K-cathepsin D and its precursor in breast cancer tissue.
Neoplasms
Telmisartan prevents aneurysm progression in the rat by inhibiting proteolysis, apoptosis and inflammation.
Neoplasms
Tenascin C and cathepsin d expression in adipocytic tumors: an immunohistochemical investigation of 43 cases.
Neoplasms
The clinical value of cathepsin-D and TNF-alpha in bladder cancer patients.
Neoplasms
The diagnostic value of lysosomal enzyme patterns in bronchial aspirates of patients with suspected bronchial carcinoma.
Neoplasms
The dilemma: Does tissue expression of cathepsin D reflect tumor malignancy? The question: Does the assay truly mirror cathepsin D mis-function in the tumor?
Neoplasms
The effect of hormone replacement therapy on prognostic indices in women with breast cancer.
Neoplasms
The Expression of Lysosomal Proteinases and Their Inhibitors in Breast Cancer: Possible Relationship to Prognosis of the Disease.
Neoplasms
The fibrinolytic system in neoplasia.
Neoplasms
The human breast cancer cell line IIB-BR-G has amplified c-myc and c-fos oncogenes in vitro and is spontaneously metastatic in vivo.
Neoplasms
The immunohistochemical expression of cathepsin D in colorectal cancer.
Neoplasms
The pathological and biological nature of screen-detected breast carcinomas: a morphological and immunohistochemical study.
Neoplasms
The pathology of low-grade adenosquamous carcinoma of the breast. An immunohistochemical study.
Neoplasms
The potential prognostic value of cathepsin D protein in serous ovarian cancer.
Neoplasms
The prognostic value of the expression of collagenase IV, cathepsin D and metallothionein in squamous cell carcinomas of the skin determined by immunohistochemistry.
Neoplasms
The prognostic-significance of cathepsin-d in breast carcinomas - an immunohistochemical study.
Neoplasms
The relative prognostic significance of total cathepsin D and HER-2/neu oncogene amplification in breast cancer. The South Australian Breast Cancer Study Group.
Neoplasms
The role of cathepsin D in the invasiveness of human breast cancer cells.
Neoplasms
The value of the lysosomal protease cathepsin-d in egyptian bladder-cancer.
Neoplasms
Three-dimensional chitosan scaffold-based MCF-7 cell culture for the determination of the cytotoxicity of tamoxifen.
Neoplasms
Three-dimensional type I collagen gel system containing MG-63 osteoblasts-like cells as a model for studying local bone reaction caused by metastatic cancer cells.
Neoplasms
Thrombin up-regulates cathepsin D which enhances angiogenesis, growth, and metastasis.
Neoplasms
Thrombospondin 1 and cathepsin D improve prostate cancer diagnosis by avoiding potentially unneeded prostate biopsies.
Neoplasms
Thrombospondin-1 and -2 in node-negative breast cancer: correlation with angiogenic factors, p53, cathepsin D, hormone receptors and prognosis.
Neoplasms
Thymidine phoshorylase expression in breast cancer: the prognostic significance and its association with other angiogenesis related proteins and extracellular matrix components.
Neoplasms
Time at surgery during menstrual cycle and menopause affects pS2 but not cathepsin D levels in breast cancer.
Neoplasms
Tissue cathepsins as tumor markers.
Neoplasms
Tissue polypeptide antigen in breast cancer cytosol: a new effective prognostic indicator.
Neoplasms
Transcriptionally active non-ligand binding oestrogen receptors in breast cancer.
Neoplasms
Transfected cathepsin D stimulates high density cancer cell growth by inactivating secreted growth inhibitors.
Neoplasms
Transformation by oncogenic ras-p21 alters the processing and subcellular localization of the lysosomal protease cathepsin D.
Neoplasms
Tumor characteristics involved in the metastatic behaviour as an improvement in primary cutaneous melanoma prognostics.
Neoplasms
Tumor growth fraction, expression of estrogen and progesterone receptors, p53, bcl-2 and cathepsin D activity in primary ductal invasive breast carcinoma and their axillary lymph node metastases.
Neoplasms
Tumor oxygenation correlates with molecular growth determinants in breast cancer.
Neoplasms
Tumor-associated proteases and inhibitors in gastric cancer: analysis of prognostic impact and individual risk protease patterns.
Neoplasms
Tumour budding intensity in relation to cathepsin D expression and some clinicopathological features of colorectal cancer.
Neoplasms
Tumour epidermal growth factor receptor, erbB-2 and cathepsin D in node-negative invasive breast cancer: their impact on the selection of patients for systemic adjuvant therapy.
Neoplasms
Tumour-associated fibrinolysis: the prognostic relevance of plasminogen activators uPA and tPA in human breast cancer.
Neoplasms
Two-dimensional gel electrophoresis of Caenorhabditis elegans homogenates and identification of protein spots by microsequencing.
Neoplasms
Urokinase-type plasminogen activator, plasminogen activator inhibitor type 1 and cathepsin D: analysis of their prognostic significance in squamous cell carcinoma of the head and neck.
Neoplasms
Variable expression of cathepsin B and D correlates with highly invasive and metastatic phenotype of oral cancer.
Neoplasms
Vorinostat and hydroxychloroquine improve immunity and inhibit autophagy in metastatic colorectal cancer.
Neoplasms
Well-differentiated adenocarcinoma, gastric foveolar type, of the extrahepatic bile ducts: A previously unrecognized and distinctive morphologic variant of bile duct carcinoma.
Neoplasms
Western blotting and isoform analysis of cathepsin D from normal and malignant human breast cell lines.
Neoplasms
Yeast as a tool to explore cathepsin D function.
Neoplasms
Zn-alpha 2-glycoprotein levels in breast cancer cytosols and correlation with clinical, histological and biochemical parameters.
Neoplasms
[A histopathologic and immunohistochemical study of prognostic factors in esophageal squamous cell carcinoma]
Neoplasms
[Activity of cathepsin D in some neoplasms of the gastrointestinal tract]
Neoplasms
[Activity of cathepsin D in the blood serum and urine of patients with cancer of the stomach, pancreas and liver]
Neoplasms
[Axillary lymph node involvement in hormone-independent breast carcinomas]
Neoplasms
[Cancer procoagulant and cathepsin D activity in blood serum in patients with bladder cancer]
Neoplasms
[Cathepsin D activity in gastric cancer]
Neoplasms
[Cathepsin D activity in human ovarian carcinoma]
Neoplasms
[Cathepsin D and B activity in the serum of patients with urothelial bladder cancer].
Neoplasms
[Cathepsin D expression in primary breast cancer. Comparison of immunohistochemical and biochemical results]
Neoplasms
[Cathepsin D in diagnosis of neoplastic diseases]
Neoplasms
[Cathepsin D in primary breast cancer in correlation with various prognostic factors]
Neoplasms
[Cathepsin D: an independent prognostic factor in cancer of the breast]
Neoplasms
[Clinical and prognostic significance of tumor-associated proteases in gynecologic oncology]
Neoplasms
[Clinico-pathological features of ER+/PR+ and ER+/PR- breast tumors: a comparative study of 5211 cases]
Neoplasms
[Cytosolic cathepsin D levels in squamous carcinomas of the lung]
Neoplasms
[Cytosolic pS2 levels and cellular proliferation in ER-positive and PgR-positive infiltrating ductal carcinomas of the breast]
Neoplasms
[Estrogens, cathepsin D and metastasis in cancers of the breast and ovary: invasion or proliferation?]
Neoplasms
[Expression of cathepsin D in breast cancer and its clinical and histopathological correlations]
Neoplasms
[Glutathione S-transferase mu 1 (GSTM1): susceptibility gene of breast cancer]
Neoplasms
[Granular cell tumor of the breast]
Neoplasms
[Immunohistochemical study of Cath-D and CD44 in laryngeal squamous cell carcinomas]
Neoplasms
[Indices of proteolysis in evaluation of resorption in bone tumors]
Neoplasms
[Involvement of cathepsin D and cathepsin E in the inhibition of tumor growth and metastasis through the production of angiogenetic inhibitors]
Neoplasms
[Mechanism of the overexpression of the cathepsin D gene in breast cancer and consequences in the metastatic process]
Neoplasms
[Modern prospects for molecular-biochemical methods for evaluating biological "behavior" of breast neoplasms]
Neoplasms
[Neoadjuvant chemotherapy, with mitoxantrone, cyclophosphamide and fluorouracil, in operable breast cancer of intermediate stage: first results of a phase II study in 40 patients]
Neoplasms
[Over-expression of Hypoxia-inducible factor 1alpha increases invasive potency of LNCaP cells in vitro]
Neoplasms
[Prognostic factors in breast cancer with contralateral supraclavicular or axillary lymphatic metastases]
Neoplasms
[Prognostic implications of biologic markers in intracranial meningiomas: 120 cases]
Neoplasms
[Prognostic significance of determining cathepsin B activity in malignant ovarian tumors]
Neoplasms
[Proteolytic enzyme activity in stomach cancer patients with various prognoses]
Neoplasms
[Proteolytic lysosomal enzymes in ovarian cancer]
Neoplasms
[Study of cathepsin D levels in invasive bladder cancer and its stroma. Correlation with tumor stage, cytological grade, lymph node metastasis and survival]
Neoplasms
[Study of the cytosolic concentrations of the tissue poly-peptide specific (TPS) antigen in infiltrating ductal carcinomas of the breast. Positive relationship with hormone dependency and negative with cellular proliferation]
Neoplasms
[The expression of cathepsin-D in salivary adenoid cystic carcinoma]
Neoplasms
[The lysosomal cathepsins B, L and D in development of murine experimental leukemias]
Neoplasms
[The prognostic significance of cathepsin D in primary breast cancer]
Neoplasms
[The prognostic value of cathepsin D concentration in cytosol of primary breast carcinoma]
Neoplasms
[The prognostic value of cathepsin D in endometrial carcinoma]
Neoplasms
[The role of cathepsin D in progression of neoplasms]
Neoplasms
[Value of immunohistochemical determination of receptors, tissue proteases, tumor suppressor proteins and proliferation markers as prognostic indicators in primary breast carcinoma]
Neoplasms, Connective Tissue
Immunolocalization of cathepsin D in normal and neoplastic human tissues.
Neoplastic Cells, Circulating
American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer.
Nephritis
Role of monocytes in cryoglobulinemia-associated nephritis.
Nephritis
[Pathogenetic significance of lipid peroxidation in damage of the proximal segment of the nephron in acute Masugi's nephritis]
Nephrotic Syndrome
Increased cathepsin D-like activity in cortex, tubules, and glomeruli isolated from rats with experimental nephrotic syndrome.
Nephrotic Syndrome
Molecular forms of beta-hexosaminidase and cathepsin D in serum and urine of healthy subjects and patients with elevated activity of lysosomal enzymes.
Nervous System Diseases
In vivo MRI reveals the dynamics of pathological changes in the brains of cathepsin D-deficient mice and correlates changes in manganese-enhanced MRI with microglial activation.
Nervous System Diseases
New insights into the roles of endolysosomal cathepsins in the pathogenesis of Alzheimer's disease: cathepsin inhibitors as potential therapeutics.
Netherton Syndrome
Epidermal differentiation: the role of proteases and their inhibitors.
Neurilemmoma
Immunohistochemical localization of lysosomal cathepsin D in schwannomas.
Neuroblastoma
Cathepsin D and its newly identified transport receptor SEZ6L2 can modulate neurite outgrowth.
Neuroblastoma
Cathepsin D protects human neuroblastoma cells from doxorubicin-induced cell death.
Neuroblastoma
Cellular distribution of cathepsin D in childhood tumors.
Neuroblastoma
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Neuroblastoma
Down-regulation of natural resistance-associated macrophage protein-1 (Nramp1) is associated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)/1-methyl-4-phenylpyridinium (MPP+ )-induced ?-synuclein accumulation and neurotoxicity.
Neuroblastoma
Limited proteolytic processing of the mature form of cathepsin D in human and mouse brain: postmortem stability of enzyme structure and activity.
Neuroblastoma
Neurotoxicity of microglial cathepsin D revealed by secretome analysis.
Neuroblastoma
The pro-survival role of autophagy depends on Bcl-2 under nutrition stress conditions.
Neurodegenerative Diseases
Altered regulation of phosphatidylinositol 3-kinase signaling in cathepsin D-deficient brain.
Neurodegenerative Diseases
Cathepsin D deficiency and NCL/Batten disease: there's more to death than apoptosis.
Neurodegenerative Diseases
Cathepsin D Deficiency and NCL/Batten Disease: There's More to Death than Apoptosis.
Neurodegenerative Diseases
Cathepsin D deficiency induces cytoskeletal changes and affects cell migration pathways in the brain.
Neurodegenerative Diseases
Cathepsin D deficiency is associated with a human neurodegenerative disorder.
Neurodegenerative Diseases
Cathepsin D Polymorphism C224T in Childhood-Onset Neurodegenerative Disorders: No Impact for Childhood Dementia.
Neurodegenerative Diseases
Cathepsin D Variants Associated With Neurodegenerative Diseases Show Dysregulated Functionality and Modified ?-Synuclein Degradation Properties.
Neurodegenerative Diseases
Cathepsin D-Managing the Delicate Balance.
Neurodegenerative Diseases
Corrigendum: Cathepsin D Variants Associated With Neurodegenerative Diseases Show Dysregulated Functionality and Modified ?-Synuclein Degradation Properties.
Neurodegenerative Diseases
Elevated levels of the endosomal-lysosomal proteinase cathepsin D in cerebrospinal fluid in Alzheimer disease.
Neurodegenerative Diseases
Knockdown of cathepsin D protects dopaminergic neurons against neuroinflammation-mediated neurotoxicity through inhibition of NF-?B signalling pathway in Parkinson's disease model.
Neurodegenerative Diseases
Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression.
Neurodegenerative Diseases
Morphologic and functional correlates of synaptic pathology in the cathepsin D knockout mouse model of congenital neuronal ceroid lipofuscinosis.
Neurodegenerative Diseases
Multi-Granulin Domain Peptides Bind to Pro-Cathepsin D and Stimulate Its Enzymatic Activity More Effectively Than Progranulin in Vitro.
Neurodegenerative Diseases
Neurotoxicity of microglial cathepsin D revealed by secretome analysis.
Neurodegenerative Diseases
Role of Apolipoprotein E, Cathepsin D, and Brain-Derived Neurotrophic Factor in Parkinson's Disease: A Study from Eastern India.
Neurodegenerative Diseases
Role of cathepsin D in U18666A-induced neuronal cell death: potential implication in Niemann-Pick type C disease pathogenesis.
Neurodegenerative Diseases
Similarities and differences in the biogenesis, processing and lysosomal targeting between zebrafish and human pro-Cathepsin D: functional implications.
Neurodegenerative Diseases
The Role of Cathepsin D in the Pathogenesis of Human Neurodegenerative Disorders.
Neuroinflammatory Diseases
Knockdown of cathepsin D protects dopaminergic neurons against neuroinflammation-mediated neurotoxicity through inhibition of NF-?B signalling pathway in Parkinson's disease model.
Neuromuscular Diseases
Lysosomal and nonlysosomal hydrolases of skeletal muscle in neuromuscular diseases.
Neuronal Ceroid-Lipofuscinoses
A mutation in the cathepsin D gene (CTSD) in American Bulldogs with neuronal ceroid lipofuscinosis.
Neuronal Ceroid-Lipofuscinoses
A novel cathepsin D mutation in 2 siblings with late infantile neuronal ceroid lipofuscinosis.
Neuronal Ceroid-Lipofuscinoses
A replacement of the active-site aspartic acid residue 293 in mouse cathepsin D affects its intracellular stability, processing and transport in HEK-293 cells.
Neuronal Ceroid-Lipofuscinoses
Accumulation of bis(monoacylglycero)phosphate and gangliosides in mouse models of neuronal ceroid lipofuscinosis.
Neuronal Ceroid-Lipofuscinoses
An Alzheimer's Disease-Linked Loss-of-Function CLN5 Variant Impairs Cathepsin D Maturation, Consistent with a Retromer Trafficking Defect.
Neuronal Ceroid-Lipofuscinoses
Cathepsin D deficiency and NCL/Batten disease: there's more to death than apoptosis.
Neuronal Ceroid-Lipofuscinoses
Cathepsin D Deficiency and NCL/Batten Disease: There's More to Death than Apoptosis.
Neuronal Ceroid-Lipofuscinoses
Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis.
Neuronal Ceroid-Lipofuscinoses
Cathepsin D-Managing the Delicate Balance.
Neuronal Ceroid-Lipofuscinoses
CNS-expressed cathepsin D prevents lymphopenia in a murine model of congenital neuronal ceroid lipofuscinosis.
Neuronal Ceroid-Lipofuscinoses
Congenital ovine neuronal ceroid lipofuscinosis--a cathepsin D deficiency with increased levels of the inactive enzyme.
Neuronal Ceroid-Lipofuscinoses
Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis.
Neuronal Ceroid-Lipofuscinoses
Genetic modifiers of degeneration in the cathepsin D deficient Drosophila model for neuronal ceroid lipofuscinosis.
Neuronal Ceroid-Lipofuscinoses
Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of ?-synuclein aggregates.
Neuronal Ceroid-Lipofuscinoses
Metabolic epilepsies: approaches to a diagnostic challenge.
Neuronal Ceroid-Lipofuscinoses
Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression.
Neuronal Ceroid-Lipofuscinoses
Morphologic and functional correlates of synaptic pathology in the cathepsin D knockout mouse model of congenital neuronal ceroid lipofuscinosis.
Neuronal Ceroid-Lipofuscinoses
Neuroectoderm-specific deletion of cathepsin D in mice models human inherited neuronal ceroid lipofuscinosis type 10.
Neuronal Ceroid-Lipofuscinoses
Purkinje Cells Are More Vulnerable to the Specific Depletion of Cathepsin D Than to That of Atg7.
Neuronal Ceroid-Lipofuscinoses
Synaptic changes in the thalamocortical system of cathepsin D-deficient mice: a model of human congenital neuronal ceroid-lipofuscinosis.
Nevus
Expression of cathepsin D in primary and metastatic human melanoma and dysplastic nevi.
Nevus
Overexpression of cathepsin D in malignant melanoma.
Newcastle Disease
Autophagy in farm animals: current knowledge and future challenges.
Niemann-Pick Disease, Type C
Role of cathepsin D in U18666A-induced neuronal cell death: potential implication in Niemann-Pick type C disease pathogenesis.
Non-alcoholic Fatty Liver Disease
Insulin resistance is positively associated with plasma cathepsin D activity in NAFLD patients.
Non-alcoholic Fatty Liver Disease
Limited applicability of cathepsin D for the diagnosis and monitoring of non-alcoholic steatohepatitis.
Non-alcoholic Fatty Liver Disease
Myosteatosis in NAFLD patients correlates with plasma Cathepsin D.
Non-alcoholic Fatty Liver Disease
Plasma cathepsin d levels: a novel tool to predict pediatric hepatic inflammation.
Non-alcoholic Fatty Liver Disease
Severity of coronary artery disease is associated with non-alcoholic fatty liver dis-ease: A single-blinded prospective mono-center study.
Non-ST Elevated Myocardial Infarction
Admission Value of Serum Cathepsin D Level Can be Useful for Predicting In-Hospital Mortality in Patients with NSTEMI.
Obesity
Cathepsin-D, a key protease in breast cancer, is up-regulated in obese mouse and human adipose tissue, and controls adipogenesis.
Obesity
Clinical prognostic factors and expression of cathepsin D in endometrioid adenocarcinoma.
Oculocerebrorenal Syndrome
Lysosomal enzymuria is a feature of hereditary Fanconi syndrome and is related to elevated CI-mannose-6-P-receptor excretion.
Oligodendroglioma
Adhesive and invasive features in gliomas.
Oligospermia
Identification and purification of an aspartic proteinase from human semen.
Osteoarthritis
Biochemical and histological changes in osteoarthritic synovial membrane.
Osteoarthritis
Comparative analysis of cathepsin L, cathepsin D, and collagenase messenger RNA expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis, by in situ hybridization.
Osteoarthritis
Identification and structure-activity relationship studies of small molecule inhibitors of the human cathepsin D.
Osteoarthritis
Structure-based optimization of non-peptidic Cathepsin D inhibitors.
Osteoarthritis
Sustained and distinctive patterns of gene activation in synovial fibroblasts and whole synovial tissue obtained from inflammatory synovitis.
Osteoarthritis
The activity of cathepsin D and alpha-1 antitrypsin in hip and knee osteoarthritis.
Osteoarthritis, Knee
Lysosomal enzymes in serum and synovial fluid in patients with osteoarthritis.
Osteoarthritis, Knee
The activity of cathepsin D and alpha-1 antitrypsin in hip and knee osteoarthritis.
Osteoarthritis, Knee
[Activity of cathepsin D and alpha-1 antitrypsin in patients with hip or knee osteoarthritis].
Osteochondritis Dissecans
Autophagy in farm animals: current knowledge and future challenges.
Osteosarcoma
Effects of Cu/Zn superoxide dismutase on estrogen responsiveness and oxidative stress in human breast cancer cells.
Osteosarcoma
Increased cathepsin D protein expression is a biomarker for osteosarcomas, pulmonary metastases and other bone malignancies.
Osteosarcoma
Proteomic approach toward molecular backgrounds of drug resistance of osteosarcoma cells in spheroid culture system.
Out-of-Hospital Cardiac Arrest
Early recurrent arrhythmias after out-of-hospital cardiac arrest associated with obstructive coronary artery disease: Analysis of the PROCAT registry.
Out-of-Hospital Cardiac Arrest
Immediate percutaneous coronary intervention is associated with better survival after out-of-hospital cardiac arrest: insights from the PROCAT (Parisian Region Out of hospital Cardiac ArresT) registry.
Ovarian Diseases
Patient-derived tumor-reactive antibodies as diagnostic markers for ovarian cancer.
Ovarian Neoplasms
Analysis of potential prognostic factors in 111 patients with ovarian cancer.
Ovarian Neoplasms
Cathepsin D antigenic epitopes identified by the humoral responses of ovarian cancer patients.
Ovarian Neoplasms
Cathepsin D assay in ovarian cancer: correlation with pathological features and receptors for oestrogen, progesterone and epidermal growth factor.
Ovarian Neoplasms
Cathepsin D immunoreactivity in ovarian cancer: correlation with prognostic factors.
Ovarian Neoplasms
Cathepsin D in ovarian cancer: prognostic value and correlation with p53 expression and microvessel density.
Ovarian Neoplasms
Cathepsin D in the Tumor Microenvironment of Breast and Ovarian Cancers.
Ovarian Neoplasms
Cathepsin D non-proteolytically induces proliferation and migration in human omental microvascular endothelial cells via activation of the ERK1/2 and PI3K/AKT pathways.
Ovarian Neoplasms
CHEMOTHERAPY DRUG RESPONSE IN OVARIAN CANCER CELLS STRICTLY DEPENDS ON A CATHEPSIN D - BAX ACTIVATION LOOP.
Ovarian Neoplasms
Clinical significance of cathepsin D in primary ovarian cancer.
Ovarian Neoplasms
Effect of fenhexamid and cyprodinil on the expression of cell cycle- and metastasis-related genes via an estrogen receptor-dependent pathway in cellular and xenografted ovarian cancer models.
Ovarian Neoplasms
Estradiol stimulates cell growth and secretion of procathepsin D and a 120-kilodalton protein in the human ovarian cancer cell line BG-1.
Ovarian Neoplasms
Expression of high molecular weight cysteine proteinase inhibitor in ovarian cancer tissues: regulation of cathepsin B expression by placental CPI.
Ovarian Neoplasms
Humoral immune responses to cathepsin D and glucose-regulated protein 78 in ovarian cancer patients.
Ovarian Neoplasms
Immunocytochemical localization of Cathepsin D and CA 125 in ovarian cancer.
Ovarian Neoplasms
Immunoradiometric and immunohistochemical analysis of Cathepsin D in ovarian cancer: lack of association with clinical outcome.
Ovarian Neoplasms
In vitro invasion assays.
Ovarian Neoplasms
Interactions of a low molecular weight inhibitor from Streptomyces sp. MBR04 with human cathepsin D: implications in mechanism of inactivation.
Ovarian Neoplasms
Modulation of proliferation and chemosensitivity by procathepsin D and its peptides in ovarian cancer.
Ovarian Neoplasms
New cathepsin d inhibitors with hydroxyethylamine isosteres: preparation and characterization.
Ovarian Neoplasms
Patient-derived tumor-reactive antibodies as diagnostic markers for ovarian cancer.
Ovarian Neoplasms
Protease levels in breast, ovary, and other gynecological tumor tissues: prognostic importance in breast cancer.
Ovarian Neoplasms
Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors.
Ovarian Neoplasms
The potential prognostic value of cathepsin D protein in serous ovarian cancer.
Ovarian Neoplasms
[Estrogens, cathepsin D and metastasis in cancers of the breast and ovary: invasion or proliferation?]
Ovarian Neoplasms
[Pro-cathepsin D can activate in vitro pro-cathepsin B secreted by ovarian cancers]
Overweight
Insulin resistance is positively associated with plasma cathepsin D activity in NAFLD patients.
Overweight
Plasma cathepsin D activity is negatively associated with hepatic insulin sensitivity in overweight and obese humans.
Pancreatic Neoplasms
Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach.
Pancreatic Neoplasms
Cathepsin D Expression and Gemcitabine Resistance in Pancreatic Cancer.
Pancreatic Neoplasms
Quantitative proteomics analysis reveals that proteins differentially expressed in chronic pancreatitis are also frequently involved in pancreatic cancer.
Pancreatic Neoplasms
The role of S100P in the invasion of pancreatic cancer cells is mediated through cytoskeletal changes and regulation of cathepsin D.
Pancreatic Neoplasms
[Activity of cathepsin D in the blood serum and urine of patients with cancer of the stomach, pancreas and liver]
Pancreatitis
Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis.
Pancreatitis
Hormonal and cholinergic effects on amylase and lysosomal enzyme activities in pancreatic tissue and ascites of rats with acute experimental pancreatitis.
Pancreatitis
Presence of cathepsin B in the human pancreatic secretory pathway and its role in trypsinogen activation during hereditary pancreatitis.
Pancreatitis
Protective effects of PGE2 on diet-induced acute pancreatitis in mice.
Pancreatitis
Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry.
Pancreatitis
Transgenic expression of GFP-LC3 perturbs autophagy in exocrine pancreas and acute pancreatitis responses in mice.
Pancreatitis, Chronic
Quantitative proteomics analysis reveals that proteins differentially expressed in chronic pancreatitis are also frequently involved in pancreatic cancer.
Papilloma
Immunohistochemical expression of cathepsin D in laryngeal epithelial lesions: correlation with CD44 expression, p53 and Rb status and proliferation associated indices.
Papillon-Lefevre Disease
Epidermal differentiation: the role of proteases and their inhibitors.
Paralysis
Proteolytic enzymes in ordinary, hyperacute, monocytic and passive transfer forms of experimental allergic encephalomyelitis.
Parkinson Disease
Comprehensive proteome analysis of an Apc mouse model uncovers proteins associated with intestinal tumorigenesis.
Parkinson Disease
Effect of Temperature and pH on the Secondary Structure and Denaturation Process of Jumbo Squid Hepatopancreas Cathepsin D.
Parkinson Disease
Identification of BAG2 and Cathepsin D as Plasma Biomarkers for Parkinson's Disease.
Parkinson Disease
Knockdown of cathepsin D protects dopaminergic neurons against neuroinflammation-mediated neurotoxicity through inhibition of NF-?B signalling pathway in Parkinson's disease model.
Parkinson Disease
Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease.
Parkinson Disease
Modulation of disease risk according to a cathepsin D / apolipoprotein E genotype in Parkinson's disease.
Parkinson Disease
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Parkinson Disease
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Parkinson Disease
Role of Apolipoprotein E, Cathepsin D, and Brain-Derived Neurotrophic Factor in Parkinson's Disease: A Study from Eastern India.
Parkinsonian Disorders
Pro-cathepsin D, Prosaposin, and Progranulin: Lysosomal Networks in Parkinsonism.
Parkinsonian Disorders
Sex differences in autophagy-mediated diseases: toward precision medicine.
Parkinsonian Disorders
Upregulation of cathepsin D in the caudate nucleus of primates with experimental parkinsonism.
Peptic Ulcer
Are tryptase and cathepsin D related to Helicobacter pylori infection and mucosal gastrin in peptic ulcer?
Peptic Ulcer
Aspartic proteinases in disease: a structural perspective.
Peptic Ulcer
Immunocytochemical evaluation of gastric mucosal cathepsin D in peptic ulcer.
Peptic Ulcer
Influence of Helicobacter pylori on tryptase and cathepsin D in peptic ulcer.
Periodontal Diseases
[Collagenase, dipeptidylpeptidase IV, and cathepsin D activities in gingival fluid and whole saliva from patients with periodontal disease (author's transl)]
Periodontitis
Possible role of lysosomal enzymes in the pathogenesis of periodontitis: a study on cathepsin D in human gingival fluid.
Periodontitis
[The proteinase inhibitors of mixed saliva in periodontitis]
Peripheral Arterial Disease
Activity of cathepsin D and alpha-glucosidase in muscle from patients with peripheral arterial disease.
Peritonitis
[Blood proteinase inhibitors and cathepsin D in diffuse peritonitis]
Peste-des-Petits-Ruminants
Autophagy in farm animals: current knowledge and future challenges.
Pheochromocytoma
Prognostic markers in pheochromocytoma.
Pituitary Neoplasms
DNA measurement, proliferation markers, and other factors in pituitary adenomas.
Pituitary Neoplasms
Expression of hypoxia-inducible factor 1alpha and cathepsin D in pituitary adenomas.
Pituitary Neoplasms
Proliferation Markers and EGF in ACTH-Secreting Adenomas and Carcinomas of the Pituitary.
Pleural Effusion
Pro-cathepsin D as a diagnostic marker in differentiating malignant from benign pleural effusion: a retrospective cohort study.
Pneumococcal Infections
A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.
Poliomyelitis
[Action of human leukocyte interferon on poliomyelitis virus reproduction in resistant MIO(r) cells]
Poliomyelitis
[Cathepsin D activity in cells differing in their sensitivity to the poliomyelitis virus]
Polycystic Kidney, Autosomal Dominant
Functional defects in lysosomal enzymes in autosomal dominant polycystic kidney disease (ADPKD): abnormalities in synthesis, molecular processing, polarity, and secretion.
Polycystic Ovary Syndrome
[Cathepsin D expression in ovaries from polycystic ovarian syndrome patients]
Pre-Eclampsia
Cathepsin D levels are reduced in patients with preeclampsia in Korean population.
Pre-Eclampsia
Elevated vasoinhibin derived from prolactin and cathepsin D activities in sera of patients with preeclampsia.
Pre-Eclampsia
Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia.
Pre-Eclampsia
Preeclampsia-associated reduction of cathepsin D activity in the umbilical cord.
Pregnancy, Ectopic
Proteinase and proteinase inhibitor localization in the human placenta.
Prion Diseases
Genetic Association of a Cathepsin D Polymorphism and Sporadic Creutzfeldt-Jakob Disease.
Prostatic Diseases
[Proteases and prostatic disease: cytosolic cathepsin D]
Prostatic Hyperplasia
Cathepsin D cytosolic assay and immunohistochemical quantification in human prostate tumors.
Prostatic Hyperplasia
Potential biomarkers for differentiation of benign prostatic hyperplasia and prostate cancer.
Prostatic Neoplasms
Analysis of cathepsin D forms and their clinical implications in human prostate cancer.
Prostatic Neoplasms
Analytical performance of thrombospondin-1 and cathepsin D immunoassays part of a novel CE-IVD marked test as an aid in the diagnosis of prostate cancer.
Prostatic Neoplasms
Camalexin-induced apoptosis in prostate cancer cells involves alterations of expression and activity of lysosomal protease cathepsin d.
Prostatic Neoplasms
Cathepsin D and epidermal growth factor receptor immunohistochemistry does not predict recurrence of prostate cancer in patients undergoing radical prostatectomy.
Prostatic Neoplasms
Cathepsin D cytosolic assay and immunohistochemical quantification in human prostate tumors.
Prostatic Neoplasms
Characterization of protease expression in human prostate-cancer cell-lines.
Prostatic Neoplasms
Distribution of cathepsin D granules in normal and pathologic conditions in human prostate.
Prostatic Neoplasms
Endogenous cathepsin D-mediated hydrolysis of insulin-like growth factor-binding proteins in cultured human prostatic carcinoma cells.
Prostatic Neoplasms
High-throughput detection of low abundance sialylated glycoproteins in human serum by TiO2 enrichment and targeted LC-MS/MS analysis: application to a prostate cancer sample set.
Prostatic Neoplasms
Hydrolysis of androgen receptor by cathepsin D: its biological significance in human prostate cancer.
Prostatic Neoplasms
Immunohistochemical analysis of cathepsin D in prostate carcinoma.
Prostatic Neoplasms
Immunohistochemical detection of cathepsin-d expression in prostate-cancer.
Prostatic Neoplasms
New cathepsin d inhibitors with hydroxyethylamine isosteres: preparation and characterization.
Prostatic Neoplasms
Olfactomedin 4 Suppresses Prostate Cancer Cell Growth and Metastasis via Negative Interaction with Cathepsin D and SDF-1.
Prostatic Neoplasms
Over-expression of hypoxia-inducible factor-1alpha increases the invasive potency of LNCaP cells in vitro.
Prostatic Neoplasms
Potential biomarkers for differentiation of benign prostatic hyperplasia and prostate cancer.
Prostatic Neoplasms
Prediction of the extent of prostate cancer by the combined use of systematic biopsy and serum level of cathepsin D.
Prostatic Neoplasms
Quantitative immunohistochemical determination of cathepsin D levels in prostatic carcinoma biopsies. Correlation with tumor grade, stage, PSA level, and DNA ploidy status.
Prostatic Neoplasms
Role of cathepsin D in prostatic cancer cell growth and its regulation by brefeldin A.
Prostatic Neoplasms
Serum cathepsin D and its density in men with prostate cancer as new predictors of disease progression.
Prostatic Neoplasms
Thrombospondin 1 and cathepsin D improve prostate cancer diagnosis by avoiding potentially unneeded prostate biopsies.
Prostatic Neoplasms
[Over-expression of Hypoxia-inducible factor 1alpha increases invasive potency of LNCaP cells in vitro]
Prostatic Neoplasms
[Proteases and prostatic disease: cytosolic cathepsin D]
Protein Deficiency
Activation of protease activity in rat peritoneal macrophages in protein deficiency: characterization of cathepsin D.
Protein Deficiency
Dietary control of cardiac lysosomal enzyme activities.
Proteinuria
Cathepsin D in Podocytes Is Important in the Pathogenesis of Proteinuria and CKD.
Proteinuria
Changes in lysosome populations in the rat kidney cortex induced by experimental proteinuria.
Proteinuria
The influence of lipoic acid on adriamycin-induced hyperlipidemic nephrotoxicity in rats.
Psoriasis
Cathepsin D expression in chronic plaque psoriasis: an immunohistochemical study.
Psoriasis
Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation.
Pulmonary Disease, Chronic Obstructive
Activity of ?1-antitrypsin and some lysosomal enzymes in the blood serum of patients with chronic obstructive pulmonary disease after smoking cessation.
Pulmonary Disease, Chronic Obstructive
Impact of cathepsin D activity and C224T polymorphism (rs17571) on chronic obstructive pulmonary disease: correlations with oxidative and inflammatory markers.
Pulmonary Disease, Chronic Obstructive
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Pulmonary Fibrosis
Altered surfactant homeostasis and alveolar epithelial cell stress in amiodarone-induced lung fibrosis.
Pulmonary Fibrosis
Immunolocalization of cathepsin D in pneumocytes of normal human lung and in pulmonary fibrosis.
Renal Insufficiency
The role of cathepsin D in the pathophysiology of heart failure and its potentially beneficial properties: a translational approach.
Renal Insufficiency, Chronic
Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease.
Renal Insufficiency, Chronic
Morin hydrate attenuates adenine-induced renal fibrosis via targeting cathepsin D signaling.
Renal Insufficiency, Chronic
Relation between serum cathepsin D levels and endothelial dysfunction in patients with chronic kidney disease.
Retinal Degeneration
Cathepsin proteases mediate photoreceptor cell degeneration in Drosophila.
Retinal Degeneration
Light induced retinal degeneration activates a caspase-independent pathway involving cathepsin D.
Retinal Degeneration
Practical considerations of recombinant adeno-associated virus-mediated gene transfer for treatment of retinal degenerations.
Retinal Degeneration
Rapid and Progressive Loss of Multiple Retinal Cell Types in Cathepsin D-Deficient Mice-An Animal Model of CLN10 Disease.
Retinal Diseases
Loss of melanoregulin (MREG) enhances cathepsin-D secretion by the retinal pigment epithelium.
Retinal Dystrophies
Rapid and Progressive Loss of Multiple Retinal Cell Types in Cathepsin D-Deficient Mice-An Animal Model of CLN10 Disease.
Retinitis Pigmentosa
Identification of proteins in retinas and IPM from eyes with retinitis pigmentosa.
Retinoblastoma
The pathological and biological nature of screen-detected breast carcinomas: a morphological and immunohistochemical study.
Rhabdomyolysis
Immunocytochemical studies of cathepsin D in human skeletal muscle.
Rheumatic Diseases
Cathepsin D agglutinators in rheumatoid arthritis. I. Increased CDA titers in serum and synovial fluid of patients with seropositive RA.
Rheumatic Diseases
Proceedings: Incidence of cathepsin D agglutinators in sera, synovial fluids, and exudate cells and synovial tissue of patients with RA and other rheumatic diseases.
Sarcoma
Proteomic expression analysis of colorectal cancer by two-dimensional differential gel electrophoresis.
Schistosomiasis
Cathepsin D immobilized capillary reactors for on-flow screening assays.
Schistosomiasis
Lipid core peptide targeting the cathepsin D hemoglobinase of Schistosoma mansoni as a component of a schistosomiasis vaccine.
Scrapie
Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes.
Scrapie
Ubiquitin immunocytochemistry in human spongiform encephalopathies.
Seizures
Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis.
Seizures
Elevated cathepsin D expression in kainate-evoked rat brain neurodegeneration.
Seizures
Picrotoxin-induced convulsions and lysosomal function in the rat brain.
Seizures
Zinc and 4-hydroxy-2-nonenal mediate lysosomal membrane permeabilization induced by H2O2 in cultured hippocampal neurons.
Shock, Septic
Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation.
Shock, Septic
Divergent results induced by different types of septic shock in transglutaminase 2 knockout mice.
Shock, Septic
Plasma lysosomal enzymes in experimental and clinical endotoxemia.
Small Cell Lung Carcinoma
Activity and tissue localization of cathepsin D in non small cell lung cancer.
Small Cell Lung Carcinoma
Secretion of a latent, acid activatable cathepsin L precursor by human non-small cell lung cancer cell lines.
Spermatic Cord Torsion
Immunohistochemical study of flotillin-1 in rat testis with ischemia/reperfusion injury.
Spinal Cord Injuries
Gene expression profiling of cathepsin D, metallothioneins-1 and -2, osteopontin, and tenascin-C in a mouse spinal cord injury model by cDNA microarray analysis.
Spinal Cord Injuries
Immunohistochemical study of cathepsin D in the spinal cords of rats with clip compression injury.
Squamous Cell Carcinoma of Head and Neck
Cathepsin D in laryngeal carcinoma. preliminary report.
Squamous Cell Carcinoma of Head and Neck
Detection of oral squamous cell carcinoma metastasis with cathepsin D: An immunohistochemical approach.
Squamous Cell Carcinoma of Head and Neck
Differential expression levels of urokinase-type plasminogen activator and cathepsin D in locally advanced laryngeal squamous cell carcinoma: clinical implications.
Squamous Cell Carcinoma of Head and Neck
Immunohistochemical analysis and prognostic value of cathepsin D determination in laryngeal squamous cell carcinoma.
ST Elevation Myocardial Infarction
Correlation between electrocardiographic changes and coronary findings in patients with acute myocardial infarction and single-vessel disease.
ST Elevation Myocardial Infarction
Role of cathepsin D activation in major adverse cardiovascular events and new-onset heart failure after STEMI.
Starvation
Aspartic Cathepsin D Endopeptidase Contributes to Extracellular Digestion in Clawed Lobsters Homarus americanus and Homarus gammarus.
Starvation
Autophagy maintains cardiac function in the starved adult.
Starvation
Cancer with low cathepsin D levels is susceptible to V-ATPase inhibition.
Starvation
Dietary control of cardiac lysosomal enzyme activities.
Starvation
Effect of starvation on global gene expression and proteolysis in rainbow trout (Oncorhynchus mykiss).
Starvation
Effects of brief starvation on brain protease activity.
Starvation
Functional significance and morphological characterization of starvation-induced autophagy in the adult heart.
Starvation
Hormonal and nutritional substrate control of cardiac lysosomal enzyme activities.
Starvation
In Vivo Evidence for Lysosome Depletion and Impaired Autophagic Clearance in Hereditary Spastic Paraplegia Type SPG11.
Starvation
Increased resistance of lipofuscin-loaded prematurely senescent fibroblasts to starvation-induced programmed cell death.
Starvation
Influence of starvation on the activities and localization of cathepsin D and other lysosomal enzymes in hearts of rabbits and mice.
Starvation
Metabolic priorities during starvation: enzyme sparing in liver and white muscle of Atlantic cod, Gadus morhua L.
Starvation
Prior starvation mitigates acute doxorubicin cardiotoxicity through restoration of autophagy in affected cardiomyocytes.
Starvation
Rabbit cardiac immunoreactive cathepsin D content during starvation-induced atrophy.
Starvation
Regulation of proteinase levels in the nematode Caenorhabditis elegans. Preferential depression by acute or chronic starvation.
Starvation
Salmon spawning migration and muscle protein metabolism: the August Krogh principle at work.
Stomach Diseases
[Activity of cathepsin D in the blood in various stomach diseases]
Stomach Neoplasms
FOXM1 facilitates gastric cancer cell migration and invasion by inducing Cathepsin D.
Stomach Neoplasms
Intracytoplasmic localization of cathepsin D reflects the invasive potential of gastric carcinoma.
Stomach Neoplasms
Micro-lymph node metastasis and its correlation with cathepsin D expression in early gastric cancer.
Stomach Neoplasms
Predictive value of cathepsin D and Ki-67 expression at the deepest penetration site for lymph node metastases in gastric cancer.
Stomach Neoplasms
Prognostic value of cytosolyc cathepsin D content in resectable gastric cancer.
Stomach Neoplasms
Proteomics-based Strategy to Delineate the Molecular Mechanisms of RhoGDI2-induced Metastasis and Drug Resistance in Gastric Cancer.
Stomach Neoplasms
Relationship of tumoral hyaluronic acid and cathepsin D contents with histological type of gastric carcinoma.
Stomach Neoplasms
Significance of Elevated Levels of Collagen Type IV and Hyaluronic Acid in Gastric Juice and Serum in Gastric Cancer and Precancerous Lesion.
Stomach Neoplasms
Tumor-associated proteases and inhibitors in gastric cancer: analysis of prognostic impact and individual risk protease patterns.
Stomach Neoplasms
VPS52 induces apoptosis via cathepsin D in gastric cancer.
Stomach Neoplasms
[Activity of cathepsin D in some neoplasms of the gastrointestinal tract]
Stomach Neoplasms
[Activity of cathepsin D in the blood serum and urine of patients with cancer of the stomach, pancreas and liver]
Stomach Neoplasms
[Cathepsin D activity in gastric cancer]
Stroke
7A.10: METABOLIC SYNDROME PREDICTS INDEPENDENTLY FROM ITS COMPONENTS ADVERSE EVENTS IN ESSENTIAL HYPERTENSIVE SUBJECTS.
Stroke
Multidisciplinary rounds (MDR): an implementation system for sustained improvement in the American Heart Association's Get With The Guidelines program.
Synovitis
Experimental arthritis of rabbits caused by intra-articular injection of autologous Fab2 produced by digestion of IgG with cathepsin D.
Synovitis
Ultrastructural studies of rabbit synovitis induced by autologous IgG fragments. II. Infiltrating cells in the sublining layer.
Synucleinopathies
Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species.
Synucleinopathies
Lysosomal enzyme activities as possible CSF biomarkers of synucleinopathies.
Tauopathies
Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy.
Tauopathies
Cathepsin D: A Candidate Link between Amyloid ?-protein and Tauopathy in Alzheimer Disease.
Tauopathies
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Tauopathies
Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.
Teratocarcinoma
Protease activity associated with loss of adhesiveness in mouse teratocarcinoma.
Teratoma
Use of a novel system for defining a gene imprinting region.
Tetanus
Application of a novel highly sensitive activity-based probe for detection of cathepsin G.
Tetanus
Natural processing sites for human cathepsin E and cathepsin D in tetanus toxin: implications for T cell epitope generation.
Thrombocytosis
The prognostic significance of p53, mdm2, c-erbB-2, cathepsin D, and thrombocytosis in stage IB cervical cancer treated by primary radical hysterectomy.
Thrombosis
Anaphylactic cardiovascular collapse and Kounis syndrome: systemic vasodilation or coronary vasoconstriction?
Thrombosis
Cathepsin D and cathepsin L activities in aortic aneurysm wall and parietal thrombus.
Thrombosis
Hemorphin 7 reflects hemoglobin proteolysis in abdominal aortic aneurysm.
Thymoma
Cell quality control mechanisms maintain stemness and differentiation potential of P19 embryonic carcinoma cells.
Thymoma
Electroacupuncture ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer disease via a novel mechanism involving activation of TFEB (transcription factor EB).
Thyroid Neoplasms
Cathepsin D in normal and neoplastic thyroid tissues.
Thyroid Neoplasms
Estrogen receptors and cathepsin D in human thyroid tissue.
Thyroid Neoplasms
Expression, localization, and thyrotropin regulation of cathepsin D in human thyroid tissues.
Thyroid Neoplasms
Lipid-rich residual bodies in the human thyroid gland: ultrastructural, histochemical, and morphometric study.
Thyrotoxicosis
Thyroid hormones and cathepsin D activity in the rat liver, kidney and brain.
Toxic Optic Neuropathy
Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of ?-secretase inhibitors.
Triple Negative Breast Neoplasms
A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment.
Triple Negative Breast Neoplasms
Cathepsin D inhibitors as potential therapeutics for breast cancer treatment: Molecular docking and bioevaluation against triple-negative and triple-positive breast cancers.
Triple Negative Breast Neoplasms
Co-Expression of Androgen Receptor and Cathepsin D Defines a Triple-Negative Breast Cancer Subgroup with Poorer Overall Survival.
Triple Negative Breast Neoplasms
Inhibition of Triple-Negative Breast Cancer Cell Aggressiveness by Cathepsin D Blockage: Role of Annexin A1.
Tuberculosis
Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited.
Tuberculosis
Differential trafficking of live and dead Mycobacterium marinum organisms in macrophages.
Tuberculosis
Lysophosphatidic acid enhances antimycobacterial activity both in vitro and ex vivo.
Tuberculosis
The role of cathepsin D in the pathogenesis of tuberculosis. A histochemical study employing unlabeled antibodies and the peroxidase-antiperoxidase complex.
Tuberculosis
Trehalose limits opportunistic mycobacterial survival during HIV co-infection by reversing HIV-mediated autophagy block.
Tuberculosis
[Comparative characteristics of the activity of proteolytic enzymes and their inhibitors in the lung tissue of guinea pigs during development of generalized and destructive tuberculosis]
Tularemia
Sequential metabolic alterations in the myocardium during influenza and tularemia in mice.
Urinary Bladder Neoplasms
An immunohistochemical and prognostic evaluation of cathepsin D expression in 105 bladder carcinomas.
Urinary Bladder Neoplasms
Cathepsin D serum and urine concentration in superficial and invasive transitional bladder cancer as determined by surface plasmon resonance imaging.
Urinary Bladder Neoplasms
Chromosomal and proteome analysis of a new T24-based cell line model for aggressive bladder cancer.
Urinary Bladder Neoplasms
Expression of cathepsin D in bladder carcinoma: correlation with pathological features and serum cystatin C levels.
Urinary Bladder Neoplasms
Expression of cathepsin D in transitional cell bladder tumours.
Urinary Bladder Neoplasms
Expression of cathepsin D in urothelial carcinoma of the urinary bladder: an immunohistochemical study including correlations with extracellular matrix components, CD44, p53, Rb, c-erbB-2 and the proliferation indices.
Urinary Bladder Neoplasms
Immunohistochemical studies of proliferating cell nuclear antigen and cathepsin D in transitional cell carcinoma of the urinary bladder.
Urinary Bladder Neoplasms
Novel blood biomarkers of human urinary bladder cancer.
Urinary Bladder Neoplasms
Prognostic significance of angiogenesis and immunoreactivity of cathepsin D and type IV collagen in high-grade stage T1 primary bladder cancer.
Urinary Bladder Neoplasms
The value of the lysosomal protease cathepsin-d in egyptian bladder-cancer.
Urinary Bladder Neoplasms
[Cancer procoagulant and cathepsin D activity in blood serum in patients with bladder cancer]
Urinary Bladder Neoplasms
[Cathepsin D and B activity in the serum of patients with urothelial bladder cancer].
Urinary Bladder Neoplasms
[Study of cathepsin D levels in invasive bladder cancer and its stroma. Correlation with tumor stage, cytological grade, lymph node metastasis and survival]
Uterine Cervical Neoplasms
Significance of cathepsin-D expression in uterine tumours.
Uterine Cervical Neoplasms
Stable transfection of the estrogen receptor cDNA into Hela cells induces estrogen responsiveness of endogenous cathepsin D gene but not of cell growth.
Uterine Cervical Neoplasms
The effect of combined therapy on activity of cathepsin D and alpha-1-antitrypsin in the blood serum of women with cervical cancer.
Uterine Cervical Neoplasms
The prognostic significance of p53, mdm2, c-erbB-2, cathepsin D, and thrombocytosis in stage IB cervical cancer treated by primary radical hysterectomy.
Uterine Hemorrhage
Clinical prognostic factors and expression of cathepsin D in endometrioid adenocarcinoma.
Uterine Neoplasms
New cathepsin d inhibitors with hydroxyethylamine isosteres: preparation and characterization.
Vaccinia
High yield synthesis and characterization of phosphorylated recombinant human procathepsin D expressed in mammalian cells.
Varicose Veins
Cathepsin D activity and protein degradation products content in the walls of varicose veins of the lower limbs.
Vesicular Stomatitis
Glucosamine promotes hepatitis B virus replication through its dual effects in suppressing autophagic degradation and inhibiting MTORC1 signaling.
Vesicular Stomatitis
Physical properties of a soluble form of the glycoprotein of vesicular stomatitis virus at neutral and acidic pH.
Virus Diseases
Astrocytosis and cathepsin D activity in experimental measles encephalomyelitis.
Virus Diseases
Peripartum cardiomyopathy. An update.
Virus Diseases
[Role of age-related serum factors in the mechanism of interferon production]
Wasting Syndrome
Muscle aspartyl protease (cathepsin D) activity: detection using a chromophoric substrate and relation to wasting in DBA/2 mice implanted with leukemic L1210 tumor cells.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3.4.23.5 cathepsin D
more
top
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
