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Information on EC 3.4.23.34 - cathepsin E and Organism(s) Mus musculus

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.34 cathepsin E
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This record set is specific for:
Mus musculus
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
similar to cathepsin D, but slightly broader specificity
Synonyms
cathepsin e, cathepsin d-like acid proteinase, cathepsin d-like protease, slow-moving proteinase, slow moving proteinase, cathepsin e-like acid proteinase, non-pepsin proteinase, cathepsin d-like aspartic proteinase, gastric mucosa non-pepsin acid proteinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Cathepsin D-like acid proteinase
-
-
-
-
cathepsin D-like protease
-
-
Cathepsin D-type proteinase
-
-
-
-
cathepsin E
Cathepsin E-like acid proteinase
-
-
-
-
CTSE
-
-
EMAP
-
-
-
-
erythrocyte membrane acid proteinase
-
-
Erythrocyte membrane aspartic proteinase
-
-
-
-
gastric mucosa non-pepsin acid proteinase
-
-
Non-pepsin proteinase
-
-
-
-
slow moving proteinase
-
-
Slow-moving proteinase
-
-
-
-
SMP
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
110910-42-4
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(7-methoxycoumarin-4-yl)acetyl-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(dinitrophenyl)-D-Arg-NH2
(7-methoxycoumarin-4-yl)acetyl-Gly-Lys-Pro-Ile-Leu-Phe + Phe-Arg-Leu-Lys(dinitrophenyl)-D-Arg-NH2
show the reaction diagram
-
-
-
-
?
Bovine serum albumin + H2O
?
show the reaction diagram
-
-
-
-
?
dynorphin A + H2O
hydrolyzed dynorphin A
show the reaction diagram
-
no cleavage at pH 7.4
-
-
?
glucagon + ATP + H2O
hydrolyzed glucagon + ?
show the reaction diagram
-
is digested at pH 4.0 but not at pH 7.4
-
-
?
MOCAc-Gly-Ser-Pro-Ala-Phe-Leu-Ala-Lys(Dnp)-D-Arg-NH2 + H2O
?
show the reaction diagram
-
-
-
-
?
neurotensin + H2O
hydrolyzed neurotensin
show the reaction diagram
-
no cleavage at pH 7.4
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
Bovine serum albumin + H2O
?
show the reaction diagram
-
-
-
-
?
MOCAc-Gly-Ser-Pro-Ala-Phe-Leu-Ala-Lys(Dnp)-D-Arg-NH2 + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Ascaris pepsin inhibitor
-
-
-
PepA-penetratin
-
efficient cell-permeable aspartic protease inhibitor
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pepstatin A
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pepA
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4
-
no cleavage at neutral pH as reported in earlier studies, only cleavage at acidic pH
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
human and rat
Manually annotated by BRENDA team
-
high relative expression of catE in adenomas and carcinomas relative to normal epithelium
Manually annotated by BRENDA team
-
high relative expression of catE in adenomas and carcinomas relative to normal epithelium
Manually annotated by BRENDA team
-
cathepsin E is secreted by activated phagocytes
Manually annotated by BRENDA team
-
of human and rat but not in guinea pig, cattle, goat or pig
Manually annotated by BRENDA team
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rat
Manually annotated by BRENDA team
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rat
Manually annotated by BRENDA team
-
increased catE levels in the urine of APC(Min/+) mice
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
in different cell types such as gastric epithelial cells, Langerhans cells, interdigitating reticulum cell and human M cells
Manually annotated by BRENDA team
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in different cell types such as gastric epithelial cells, Langerhans cells, interdigitating reticulum cell and human M cells
-
Manually annotated by BRENDA team
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Cat E is partially present in lysosomes
Manually annotated by BRENDA team
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cathepsin E is located in mast-cell secretory granules in complex with heparin proteoglycans, and has a role in processing of procarboxypeptidase A into active protease
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
-
enzyme-deficient mice are highly resistant to myelin oligodendrocyte glycoprotein 35-55-induced mechanical allodynia
physiological function
-
cathepsin E in neutrophils contributes to the generation of mechanical allodynia in experimental autoimmune encephalomyelitis. The enzyme is required for the enzymatic activity of elastase in neutrophils after myelin oligodendrocyte glycoprotein 35-55 stimulation
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CATE_MOUSE
397
0
42938
Swiss-Prot
Secretory Pathway (Reliability: 2)
D3Z6T3_MOUSE
364
0
39247
TrEMBL
Secretory Pathway (Reliability: 2)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 42000, SDS-PAGE
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D98A/D283A
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expression in HEK293T cells
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
DEAE-Sephacel chromatography and immunodepletion
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in HEK293T cells of wild-type and mutant form
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme activity is increased in CD4+ cells of lupus-prone mice. Enzyme expression is up-regulated under the treatment of the DNA methylation inhibitor 5-azaC or trichostatin A in EL-4 cells
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MOG35-55 directly binds to toll-like receptor 4, which leads to increased production of the enzyme in neutrophils
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
molecular biology
-
CatE is a potential cancer biomarker
additional information
-
CatE is essential for processing of ovalbumin by murine B-cells, Cat E could play a major role in antigen processing, involvement of CatE in the MHC class II pathway
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Henningsson, F.; Yamamoto, K.; Saftig, P.; Reinheckel, T.; Peters, C.; Knight, S.D.; Pejler, G.
A role for cathepsin E in the processing of mast-cell carboxypeptidase A
J. Cell Sci.
118
2035-2042
2005
Mus musculus
Manually annotated by BRENDA team
Chain, B.M.; Free, P.; Medd, P.; Swetman, C.; Tabor, A.B.; Terrazzini, N.
The expression and function of cathepsin E in dendritic cells
J. Immunol.
174
1791-1800
2005
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Busquets, L.; Guillen, H.; DeFord, M.E.; Suckow, M.A.; Navari, R.M.; Castellino, F.J.; Prorok, M.
Cathepsin E is a specific marker of dysplasia in APC mouse intestine
Tumour Biol.
27
36-42
2006
Mus musculus
Manually annotated by BRENDA team
Zaidi, N.; Herrmann, T.; Voelter, W.; Kalbacher, H.
Recombinant cathepsin E has no proteolytic activity at neutral pH
Biochem. Biophys. Res. Commun.
360
51-55
2007
Mus musculus
Manually annotated by BRENDA team
Zaidi, N.; Kalbacher, H.
Cathepsin E: a mini review
Biochem. Biophys. Res. Commun.
367
517-522
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Kawakubo, T.; Okamoto, K.; Iwata, J.; Shin, M.; Okamoto, Y.; Yasukochi, A.; Nakayama, K.I.; Kadowaki, T.; Tsukuba, T.; Yamamoto, K.
Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface
Cancer Res.
67
10869-10878
2007
Mus musculus
Manually annotated by BRENDA team
Kakehashi, H.; Nishioku, T.; Tsukuba, T.; Kadowaki, T.; Nakamura, S.; Yamamoto, K.
Differential regulation of the nature and functions of dendritic cells and macrophages by cathepsin E
J. Immunol.
179
5728-5737
2007
Mus musculus
Manually annotated by BRENDA team
Tsukuba, T.; Yanagawa, M.; Okamoto, K.; Okamoto, Y.; Yasuda, Y.; Nakayama, K.I.; Kadowaki, T.; Yamamoto, K.
Impaired chemotaxis and cell adhesion due to decrease in several cell-surface receptors in cathepsin E-deficient macrophages
J. Biochem.
145
565-573
2009
Mus musculus (P70269)
Manually annotated by BRENDA team
Shigematsu, N.; Fukuda, T.; Yamamoto, T.; Nishioku, T.; Yamaguchi, T.; Himeno, M.; Nakayama, K.I.; Tsukuba, T.; Kadowaki, T.; Okamoto, K.; Higuchi, S.; Yamamoto, K.
Association of cathepsin E deficiency with the increased territorial aggressive response of mice
J. Neurochem.
105
1394-1404
2008
Mus musculus
Manually annotated by BRENDA team
Harada, Y.; Zhang, J.; Imari, K.; Yamasaki, R.; Ni, J.; Wu, Z.; Yamamoto, K.; Kira, J.I.; Nakanishi, H.; Hayashi, Y.
Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis
Pain
160
2050-2062
2019
Mus musculus
Manually annotated by BRENDA team
Hiramatsu, S.; Watanabe, K.S.; Zeggar, S.; Asano, Y.; Miyawaki, Y.; Yamamura, Y.; Katsuyama, E.; Katsuyama, T.; Watanabe, H.; Takano-Narazaki, M.; Matsumoto, Y.; Kawabata, T.; Sada, K.E.; Wada, J.
Regulation of cathepsin E gene expression by the transcription factor Kaiso in MRL/lpr mice derived CD4+ T cells
Sci. Rep.
9
3054
2019
Mus musculus
Manually annotated by BRENDA team