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Acute Kidney Injury
Protective role of endothelial calpain knockout in lipopolysaccharide-induced acute kidney injury via attenuation of the p38-iNOS pathway and NO/ROS production.
Adenocarcinoma of Lung
miR-124 suppresses proliferation and invasion of nasopharyngeal carcinoma cells through the Wnt/?-catenin signaling pathway by targeting Capn4.
Breast Neoplasms
The oncoprotein HBXIP enhances migration of breast cancer cells through increasing filopodia formation involving MEKK2/ERK1/2/Capn4 signaling.
Carcinogenesis
Calpain Small Subunit 1 Protein in the Prognosis of Cancer Survivors and Its Clinicopathological Correlation.
Carcinogenesis
Increased Expression of Capn4 is Associated with the Malignancy of Human Glioma.
Carcinoma
Capn4 contributes to tumor invasion and metastasis in clear cell renal cell carcinoma cells via modulating talin-focal adhesion kinase signaling pathway.
Carcinoma
Capn4 Enhances Osteopontin Expression through Activation of the Wnt/?-Catenin Pathway to Promote Epithelial Ovarian Carcinoma Metastasis.
Carcinoma
Capn4 mRNA level is correlated with tumour progression and clinical outcome in clear cell renal cell carcinoma.
Carcinoma
Capn4 promotes esophageal squamous cell carcinoma metastasis by regulating ZEB1 through the Wnt/?-catenin signaling pathway.
Carcinoma
Capn4 regulates migration and invasion of ovarian carcinoma cells via targeting osteopontin-mediated PI3K/AKT signaling pathway.
Carcinoma
High expression of Capn4 is associated with metastasis and poor prognosis in esophageal squamous cell carcinoma.
Carcinoma
MiR-337-3p suppresses the proliferation and metastasis of clear cell renal cell carcinoma cells via modulating Capn4.
Carcinoma, Hepatocellular
Capn4 contributes to tumour growth and metastasis of hepatocellular carcinoma by activation of the FAK-Src signalling pathways.
Carcinoma, Hepatocellular
Capn4 overexpression underlies tumor invasion and metastasis after liver transplantation for hepatocellular carcinoma.
Carcinoma, Hepatocellular
Hepatitis B Virus X Protein Drives Multiple Cross-Talk Cascade Loops Involving NF-?B, 5-LOX, OPN and Capn4 to Promote Cell Migration.
Carcinoma, Hepatocellular
Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kappaB/p65 in hepatoma cells.
Carcinoma, Hepatocellular
Overexpression of Capns1 Predicts Poor Prognosis and Correlates with Tumor Progression in Renal Cell Carcinoma.
Carcinoma, Hepatocellular
Prognostic significance of Capn4 overexpression in intrahepatic cholangiocarcinoma.
Carcinoma, Non-Small-Cell Lung
Capn4 promotes non-small cell lung cancer progression via upregulation of matrix metalloproteinase 2.
Carcinoma, Ovarian Epithelial
Capn4 Enhances Osteopontin Expression through Activation of the Wnt/?-Catenin Pathway to Promote Epithelial Ovarian Carcinoma Metastasis.
Carcinoma, Renal Cell
Capn4 contributes to tumor invasion and metastasis in clear cell renal cell carcinoma cells via modulating talin-focal adhesion kinase signaling pathway.
Carcinoma, Renal Cell
Capn4 mRNA level is correlated with tumour progression and clinical outcome in clear cell renal cell carcinoma.
Carcinoma, Renal Cell
MiR-337-3p suppresses the proliferation and metastasis of clear cell renal cell carcinoma cells via modulating Capn4.
Cholangiocarcinoma
Overexpression of Capns1 Predicts Poor Prognosis and Correlates with Tumor Progression in Renal Cell Carcinoma.
Cholangiocarcinoma
Prognostic significance of Capn4 overexpression in intrahepatic cholangiocarcinoma.
Colorectal Neoplasms
Capn4 promotes colorectal cancer cell proliferation by increasing MAPK7 through activation of the Wnt/?-Catenin pathway.
Colorectal Neoplasms
Suppression of Capn4 by microRNA-1271 impedes the proliferation and invasion of colorectal cancer cells.
Endotoxemia
Deletion of capn4 Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide Generation.
Endotoxemia
Protective role of endothelial calpain knockout in lipopolysaccharide-induced acute kidney injury via attenuation of the p38-iNOS pathway and NO/ROS production.
Esophageal Neoplasms
High expression of Capn4 is associated with metastasis and poor prognosis in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Capn4 promotes esophageal squamous cell carcinoma metastasis by regulating ZEB1 through the Wnt/?-catenin signaling pathway.
Esophageal Squamous Cell Carcinoma
High expression of Capn4 is associated with metastasis and poor prognosis in esophageal squamous cell carcinoma.
Glioblastoma
miR-124 suppresses the migration and invasion of glioma cells in vitro via Capn4.
Glioma
Increased Expression of Capn4 is Associated with the Malignancy of Human Glioma.
Glioma
miR-124 suppresses the migration and invasion of glioma cells in vitro via Capn4.
Heart Failure
Calpain protects the heart from hemodynamic stress.
Hepatitis B
Hepatitis B Virus X Protein Drives Multiple Cross-Talk Cascade Loops Involving NF-?B, 5-LOX, OPN and Capn4 to Promote Cell Migration.
Hepatitis B
Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kappaB/p65 in hepatoma cells.
Kidney Neoplasms
Capn4 induces human renal cancer cell proliferation by activating NF-?B signaling pathway through FAK phosphorylation.
Lung Neoplasms
Capn4 promotes non-small cell lung cancer progression via upregulation of matrix metalloproteinase 2.
Lymphatic Metastasis
Capn4 promotes non-small cell lung cancer progression via upregulation of matrix metalloproteinase 2.
Lymphatic Metastasis
High expression of Capn4 is associated with metastasis and poor prognosis in esophageal squamous cell carcinoma.
Melanoma
Capn4 promotes epithelial-mesenchymal transition in human melanoma cells through activation of the Wnt/?-catenin pathway.
Myocardial Infarction
Deficiency of Capn4 Gene Inhibits Nuclear Factor-?B (NF-?B) Protein Signaling/Inflammation and Reduces Remodeling after Myocardial Infarction.
Nasopharyngeal Carcinoma
Capn4 Is a Marker of Poor Clinical Outcomes and Promotes Nasopharyngeal Carcinoma Metastasis via NF-?B-Induced MMP2 Expression.
Nasopharyngeal Carcinoma
Capn4 is induced by and required for Epstein-Barr virus latent membrane protein 1 promotion of nasopharyngeal carcinoma metastasis through ERK/AP-1 signaling.
Nasopharyngeal Carcinoma
miR-124 suppresses proliferation and invasion of nasopharyngeal carcinoma cells through the Wnt/?-catenin signaling pathway by targeting Capn4.
Neoplasm Metastasis
Capn4 contributes to tumor invasion and metastasis in clear cell renal cell carcinoma cells via modulating talin-focal adhesion kinase signaling pathway.
Neoplasm Metastasis
Capn4 contributes to tumor invasion and metastasis in gastric cancer via activation of the Wnt/?-catenin/MMP9 signalling pathways.
Neoplasm Metastasis
Capn4 contributes to tumour growth and metastasis of hepatocellular carcinoma by activation of the FAK-Src signalling pathways.
Neoplasm Metastasis
Capn4 Enhances Osteopontin Expression through Activation of the Wnt/?-Catenin Pathway to Promote Epithelial Ovarian Carcinoma Metastasis.
Neoplasm Metastasis
Capn4 Is a Marker of Poor Clinical Outcomes and Promotes Nasopharyngeal Carcinoma Metastasis via NF-?B-Induced MMP2 Expression.
Neoplasm Metastasis
Capn4 is induced by and required for Epstein-Barr virus latent membrane protein 1 promotion of nasopharyngeal carcinoma metastasis through ERK/AP-1 signaling.
Neoplasm Metastasis
Capn4 overexpression indicates poor prognosis of ovarian cancer patients.
Neoplasm Metastasis
Capn4 overexpression underlies tumor invasion and metastasis after liver transplantation for hepatocellular carcinoma.
Neoplasm Metastasis
Capn4 promotes esophageal squamous cell carcinoma metastasis by regulating ZEB1 through the Wnt/?-catenin signaling pathway.
Neoplasm Metastasis
Capn4 promotes non-small cell lung cancer progression via upregulation of matrix metalloproteinase 2.
Neoplasm Metastasis
Capn4 regulates migration and invasion of ovarian carcinoma cells via targeting osteopontin-mediated PI3K/AKT signaling pathway.
Neoplasm Metastasis
Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kappaB/p65 in hepatoma cells.
Neoplasm Metastasis
High expression of Capn4 is associated with metastasis and poor prognosis in esophageal squamous cell carcinoma.
Neoplasm Metastasis
miR-124 suppresses proliferation and invasion of nasopharyngeal carcinoma cells through the Wnt/?-catenin signaling pathway by targeting Capn4.
Neoplasm Metastasis
MiR-337-3p suppresses the proliferation and metastasis of clear cell renal cell carcinoma cells via modulating Capn4.
Neoplasm Metastasis
Overexpression of Capns1 Predicts Poor Prognosis and Correlates with Tumor Progression in Renal Cell Carcinoma.
Neoplasms
Calpain Small Subunit 1 Protein in the Prognosis of Cancer Survivors and Its Clinicopathological Correlation.
Neoplasms
Capn4 contributes to tumor invasion and metastasis in clear cell renal cell carcinoma cells via modulating talin-focal adhesion kinase signaling pathway.
Neoplasms
Capn4 contributes to tumor invasion and metastasis in gastric cancer via activation of the Wnt/?-catenin/MMP9 signalling pathways.
Neoplasms
Capn4 contributes to tumour growth and metastasis of hepatocellular carcinoma by activation of the FAK-Src signalling pathways.
Neoplasms
Capn4 Enhances Osteopontin Expression through Activation of the Wnt/?-Catenin Pathway to Promote Epithelial Ovarian Carcinoma Metastasis.
Neoplasms
Capn4 expression is modulated by microRNA-520b and exerts an oncogenic role in prostate cancer cells by promoting Wnt/?-catenin signaling.
Neoplasms
Capn4 induces human renal cancer cell proliferation by activating NF-?B signaling pathway through FAK phosphorylation.
Neoplasms
Capn4 Is a Marker of Poor Clinical Outcomes and Promotes Nasopharyngeal Carcinoma Metastasis via NF-?B-Induced MMP2 Expression.
Neoplasms
Capn4 mRNA level is correlated with tumour progression and clinical outcome in clear cell renal cell carcinoma.
Neoplasms
Capn4 overexpression indicates poor prognosis of ovarian cancer patients.
Neoplasms
Capn4 overexpression underlies tumor invasion and metastasis after liver transplantation for hepatocellular carcinoma.
Neoplasms
Capn4 promotes colorectal cancer cell proliferation by increasing MAPK7 through activation of the Wnt/?-Catenin pathway.
Neoplasms
Capn4 promotes epithelial-mesenchymal transition in human melanoma cells through activation of the Wnt/?-catenin pathway.
Neoplasms
Capn4 promotes esophageal squamous cell carcinoma metastasis by regulating ZEB1 through the Wnt/?-catenin signaling pathway.
Neoplasms
Capn4 promotes non-small cell lung cancer progression via upregulation of matrix metalloproteinase 2.
Neoplasms
Cyclin E in breast tumors is cleaved into its low molecular weight forms by calpain.
Neoplasms
Growth of hepatocellular carcinoma in the regenerating liver.
Neoplasms
High expression of Capn4 is associated with metastasis and poor prognosis in esophageal squamous cell carcinoma.
Neoplasms
Increased Expression of Capn4 is Associated with the Malignancy of Human Glioma.
Neoplasms
Suppression of Capn4 by microRNA-1271 impedes the proliferation and invasion of colorectal cancer cells.
Neoplasms, Squamous Cell
High expression of Capn4 is associated with metastasis and poor prognosis in esophageal squamous cell carcinoma.
Ovarian Neoplasms
Capn4 Enhances Osteopontin Expression through Activation of the Wnt/?-Catenin Pathway to Promote Epithelial Ovarian Carcinoma Metastasis.
Ovarian Neoplasms
Capn4 overexpression indicates poor prognosis of ovarian cancer patients.
Prostatic Neoplasms
Capn4 expression is modulated by microRNA-520b and exerts an oncogenic role in prostate cancer cells by promoting Wnt/?-catenin signaling.
Retinoblastoma
Calpain modulates cyclin-dependent kinase inhibitor 1B (p27(Kip1)) in cells of the osteoblast lineage.
Stomach Neoplasms
Capn4 contributes to tumor invasion and metastasis in gastric cancer via activation of the Wnt/?-catenin/MMP9 signalling pathways.
Stomach Neoplasms
MiR-99a and MiR-491 Regulate Cisplatin Resistance in Human Gastric Cancer Cells by Targeting CAPNS1.
Virus Diseases
Capn4 Is a Marker of Poor Clinical Outcomes and Promotes Nasopharyngeal Carcinoma Metastasis via NF-?B-Induced MMP2 Expression.
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Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Bos taurus (P13135), Homo sapiens (P04632), Mus musculus (O88456), Rattus norvegicus (Q64537), Sus scrofa (P04574)
brenda
Strobl S.; Fernandez-Catalan C.; Braun M.; Huber R.; Masumoto H.; Nakagawa K.; Irie A.; Sorimachi H.; Bourenkow G.; Bartunik H.; Suzuki K.; Bode W.
The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium
Proc. Natl. Acad. Sci. USA
97
588-592
2000
Homo sapiens (P04632)
brenda
Strausberg R.L.; Feingold E.A.; Grouse L.H.; Derge J.G.; et al.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
Proc. Natl. Acad. Sci. USA
99
16899-16903
2002
Homo sapiens (P04632), Mus musculus (O88456)
brenda
Ohno, S.; Emori, Y.; Suzuki, K.
Nucleotide sequence of a cDNA coding for the small subunit of human calcium-dependent protease
Nucleic Acids Res.
14
5559-5559
1986
Homo sapiens (P04632)
brenda
Miyake S.; Emori Y.; Suzuki K.
Gene organization of the small subunit of human calcium-activated neutral protease
Nucleic Acids Res.
14
8805-8817
1986
Homo sapiens (P04632)
brenda
Rosenberger, G.; Gal, A.; Kutsche, K.
AlphaPIX associates with calpain 4, the small subunit of calpain, and has a dual role in integrin-mediated cell spreading
J. Biol. Chem.
280
6879-6889
2005
Homo sapiens
brenda
Carragher, N.O.
Calpain inhibition: a therapeutic strategy targeting multiple disease states
Curr. Pharm. Des.
12
615-638
2006
Homo sapiens, Rattus norvegicus, Sus scrofa
brenda
Bai, D.S.; Dai, Z.; Zhou, J.; Liu, Y.K.; Qiu, S.J.; Tan, C.J.; Shi, Y.H.; Huang, C.; Wang, Z.; He, Y.F.; Fan, J.
Capn4 overexpression underlies tumor invasion and metastasis after liver transplantation for hepatocellular carcinoma
Hepatology
49
460-470
2009
Homo sapiens
brenda
Zhang, F.; Wang, Q.; Ye, L.; Feng, Y.; Zhang, X.
Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kappaB/p65 in hepatoma cells
J. Med. Virol.
82
920-928
2010
Homo sapiens
brenda
Peng, P.; Min, L.; Song, S.; Zhao, J.; Li, L.; Yang, C.; Shao, M.; Zhang, M.; Wu, H.; Zhang, J.; Li, C.; Wang, X.; Wang, H.; Qin, J.; Ruan, Y.; Gu, J.
Elevated expression of calpain-4 predicts poor prognosis in patients with gastric cancer after gastrectomy
Int. J. Mol. Sci.
17
1612
2016
Homo sapiens
brenda
3.4.22.B24 calpain 4
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
