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Abz-(Xaa)n-Tyr(NO2)-Asp-OH + H2O
?
-
-
-
?
beta-casein + H2O
?
-
-
-
?
beta-conglycinin + H2O
?
-
extensive hydrolysis
-
-
?
Boc-Asn 4-nitrophenyl ester + H2O
Boc-Asn + 4-nitrophenol
-
-
-
?
Bz-Asn-p-nitroanilide + H2O
p-nitroaniline + Bz-Asn
Bz-Phe-Val-Arg-p-nitroanilide + H2O
p-nitroaniline + Bz-Phe-Val-Arg
CBZ-Phe-Arg-7-amido-4-methylcoumarin + H2O
?
-
-
-
?
phaseolin + H2O
?
-
Cleavage of the phaseolin subunits into roughly half-sized fragments at the onset of proteolysis, only 8-10% decrease of protein
-
-
?
Z-Phe-Arg-7-amido-4-methylcoumarin + H2O
?
-
-
-
-
?
additional information
?
-
azocasein + H2O
?
-
-
-
-
?
azocasein + H2O
?
-
-
-
?
Bz-Asn-p-nitroanilide + H2O
p-nitroaniline + Bz-Asn
-
-
-
-
?
Bz-Asn-p-nitroanilide + H2O
p-nitroaniline + Bz-Asn
-
-
-
-
?
Bz-Phe-Val-Arg-p-nitroanilide + H2O
p-nitroaniline + Bz-Phe-Val-Arg
-
-
-
-
?
Bz-Phe-Val-Arg-p-nitroanilide + H2O
p-nitroaniline + Bz-Phe-Val-Arg
-
-
-
-
?
additional information
?
-
neutral amino acid residues with large aliphatic and non-polar or aromatic side-chains at the P2 position are good substrates
-
-
?
additional information
?
-
-
neutral amino acid residues with large aliphatic and non-polar or aromatic side-chains at the P2 position are good substrates
-
-
?
additional information
?
-
-
the enzyme acts to degrade the seed storage protein in protein storage vacuoles
-
-
?
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Dehydration
Expression of cysteine protease genes in pea nodule development and senescence.
Infections
Propagation of the human polyomavirus, JCV, in human neuroblastoma cell lines.
Leukemia
Decreased sensitivity of drug-resistant cells towards T cell cytotoxicity.
Neoplasms
A Pilot Study on the Utility of Serum Metabolomics in Neuroblastoma Patients and Xenograft Models.
Neoplasms
Inhibition of clonogenic tumor growth: a novel function of Smac contributing to its antitumor activity.
Neoplasms
MYC activity is negatively regulated by a C-terminal lysine cluster.
Neoplasms
PHA665752, a small-molecule inhibitor of c-Met, inhibits hepatocyte growth factor-stimulated migration and proliferation of c-Met-positive neuroblastoma cells.
Neuroblastoma
?-Actin regulates cell migration and modulates the ROCK signaling pathway.
Neuroblastoma
A restrictive element 1 (RE-1) in the VIP gene modulates transcription in neuronal and non-neuronal cells in collaboration with an upstream tissue specifier element.
Neuroblastoma
A retroviral expression system based on tetracycline-regulated tricistronic transactivator/repressor vectors for functional analyses of antiproliferative and toxic genes.
Neuroblastoma
ABCC Multidrug Transporters in Childhood Neuroblastoma: Clinical and Biological Effects Independent of Cytotoxic Drug Efflux.
Neuroblastoma
Alterations in gamma-actin and tubulin-targeted drug resistance in childhood leukemia.
Neuroblastoma
Altered expression of the MYCN oncogene modulates MRP gene expression and response to cytotoxic drugs in neuroblastoma cells.
Neuroblastoma
AQP1 Is Up-Regulated by Hypoxia and Leads to Increased Cell Water Permeability, Motility, and Migration in Neuroblastoma.
Neuroblastoma
Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy.
Neuroblastoma
Block Co-polymer Nanoparticles with Degradable Cross-Linked Core and Low-Molecular-Weight PEG Corona for Anti-tumour Drug Delivery.
Neuroblastoma
Cytotoxicity of lymphokine-activated killer cells against human neuroblastoma cells: modulation by neuroblast differentiation.
Neuroblastoma
Decreased sensitivity of drug-resistant cells towards T cell cytotoxicity.
Neuroblastoma
Differences in centromere positioning of cycling and postmitotic human cell types.
Neuroblastoma
Differential regulation of insulin receptor substrate-1 degradation during mannitol and okadaic acid induced apoptosis in human neuroblastoma cells.
Neuroblastoma
Differentiation-related expression of adhesion molecules and receptors on human neuroblastoma tissues, cell lines and variants.
Neuroblastoma
Direct evidence for two distinct G proteins coupling with thrombin receptors in human neuroblastoma SH-EP cells.
Neuroblastoma
Expression of the B cell-associated tyrosine kinase gene Lyn in primary neuroblastoma tumours and its modulation during the differentiation of neuroblastoma cell lines.
Neuroblastoma
Functional vasoactive intestinal polypeptide (VIP) receptors in human neuroblastoma subclones that contain VIP precursor mRNA and release VIP-like substances.
Neuroblastoma
Increased epidermal growth factor receptor in multidrug-resistant human neuroblastoma cells.
Neuroblastoma
Inhibition of clonogenic tumor growth: a novel function of Smac contributing to its antitumor activity.
Neuroblastoma
Insulin receptor substrate (IRS)-2, not IRS-1, protects human neuroblastoma cells against apoptosis.
Neuroblastoma
Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt.
Neuroblastoma
Insulin-like growth factor-II as a paracrine growth factor in human neuroblastoma cells.
Neuroblastoma
LIM-kinase 2, a regulator of actin dynamics, is involved in mitotic spindle integrity and sensitivity to microtubule-destabilizing drugs.
Neuroblastoma
MYC phosphorylation at novel regulatory regions suppresses transforming activity.
Neuroblastoma
N-myc augments death and attenuates protective effects of Bcl-2 in trophically stressed neuroblastoma cells.
Neuroblastoma
Neuroblastoma progression correlates with downregulation of the lymphangiogenesis inhibitor sVEGFR-2.
Neuroblastoma
Neurotoxin-induced pathway perturbation in human neuroblastoma SH-EP cells.
Neuroblastoma
Next-generation RNA sequencing reveals differential expression of MYCN target genes and suggests the mTOR pathway as a promising therapy target in MYCN-amplified neuroblastoma.
Neuroblastoma
Persistent inhibition of FLIP(L) expression by lentiviral small hairpin RNA delivery restores death-receptor-induced apoptosis in neuroblastoma cells.
Neuroblastoma
Sirtuin 5 is Anti-apoptotic and Anti-oxidative in Cultured SH-EP Neuroblastoma Cells.
Neuroblastoma
Surface marker profiling of SH-SY5Y cells enables small molecule screens identifying BMP4 as a modulator of neuroblastoma differentiation.
Neuroblastoma
Targeting Id protein interactions by an engineered HLH domain induces human neuroblastoma cell differentiation.
Neuroblastoma
Taurolidine cooperates with antineoplastic drugs in neuroblastoma cells.
Neuroblastoma
Thrombin is the major serum factor stimulating phosphoinositide turnover, but not DNA synthesis in human neuroblastoma SH-EP cells.
Neuroblastoma
Thrombin stimulates pertussis toxin-sensitive and -insensitive GTPase activities and ADP-ribosylation of G(i) in human neuroblastoma SH-EP.
Neuroblastoma
Tissue-specific expression of the vasoactive intestinal peptide gene requires both an upstream tissue specifier element and the 5' proximal cyclic AMP-responsive element.
Neuroblastoma
TRAIL enhances thymidine kinase/ganciclovir gene therapy of neuroblastoma cells.
Neuroblastoma
Transcription factor activating protein 2 beta (TFAP2B) mediates noradrenergic neuronal differentiation in neuroblastoma.
Neuroblastoma
Transcription factor AP2alpha (TFAP2a) regulates differentiation and proliferation of neuroblastoma cells.
Neuroblastoma
Two separate cis-active elements of the vasoactive intestinal peptide gene mediate constitutive and inducible transcription by binding different sets of AP-1 proteins.
Neuroblastoma
Upstream ORF affects MYCN translation depending on exon 1b alternative splicing.
Whooping Cough
The epithelial phenotype of human neuroblastoma cells express bradykinin, endothelin, and angiotensin II receptors that stimulate phosphoinositide hydrolysis.
Whooping Cough
Thrombin stimulates pertussis toxin-sensitive and -insensitive GTPase activities and ADP-ribosylation of G(i) in human neuroblastoma SH-EP.
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Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Vigna mungo (P12412)
brenda
Akasofu H.; Yamauchi D.; Mitsuhashi W.; Minamikawa T.
Nucleotide sequence of cDNA for sulfhydryl-endopeptidase (SH-EP) from cotyledons of germinating Vigna mungo seeds
Nucleic Acids Res.
17
6733-6733
1989
Vigna mungo (P12412), Vigna mungo
brenda
Akasofu H.; Yamauchi D.; Minamikawa T.
Nucleotide sequence of the gene for the Vigna mungo sulfhydryl-endopeptidase (SH-EP)
Nucleic Acids Res.
18
1892-1892
1990
Vigna mungo (P12412), Vigna mungo
brenda
Okamoto, T.; Minamikawa, T.
Purification of a processing enzyme (VmPE-1) that is involved in post-translational processing of a plant cysteine endopeptidase (SH-EP)
Eur. J. Biochem.
231
300-305
1995
Vigna mungo
brenda
Mitsuhashi, W.; Minamikawa, T.
Synthesis and posttranslational activation of sulfhydryl-endopeptidase in cotyledons of germinating Vigna mungo seeds
Plant Physiol.
89
274-279
1989
Vigna mungo
brenda
Okamoto, T.; Toyooka, K.; Minamikawa, T.
Identification of a membrane-associated cysteine protease with possible dual roles in the endoplasmic reticulum and protein storage vacuole
J. Biol. Chem.
276
742-751
2001
Vigna mungo
brenda
Zakharov, A.; Carchilan, M.; Stepurina, T.; Rotari, V.; Wilson, K.; Vaintraub I.
A comparative study of the role of the major proteinases of germinated common bean (Phaseolus vulgaris L.) and soybean (Glycine max (L.) Merrill) seeds in the degradation of their storage proteins
J. Exp. Bot.
55
2241-2249
2004
Glycine max, Phaseolus vulgaris
brenda
Beyene, G.; Foyer, C.H.; Kunert, K.J.
Two new cysteine proteinases with specific expression patterns in mature and senescent tobacco (Nicotiana tabacum L.) leaves
J. Exp. Bot.
57
1431-1443
2006
Nicotiana tabacum
brenda
Than, M.E.; Helm, M.; Simpson, D.J.; Lottspeich, F.; Huber, R.; Gietl, C.
The 2.0 A crystal structure and substrate specificity of the KDEL-tailed cysteine endopeptidase functioning in programmed cell death of Ricinus communis endosperm
J. Mol. Biol.
336
1103-1116
2004
Ricinus communis (O65039), Ricinus communis
brenda
Sheokand, S.; Dahiya, P.; Vincent, J.L.; Brewin, N.J.
Modified expression of cysteine protease affects seed germination, vegetative growth and nodule development in transgenic lines of Medicago truncatula
Plant Sci.
169
966-975
2005
Medicago truncatula
brenda
Greenwood, J.S.; Helm, M.; Gietl, C.
Ricinosomes and endosperm transfer cell structure in programmed cell death of the nucellus during Ricinus seed development
Proc. Natl. Acad. Sci. USA
102
2238-2243
2005
Ricinus communis
brenda