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Information on EC 3.4.22.68 - Ulp1 peptidase and Organism(s) Mus musculus

for references in articles please use BRENDA:EC3.4.22.68
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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.68 Ulp1 peptidase
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This record set is specific for:
Mus musculus
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-/-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein
Synonyms
senp1, senp2, sumo protease, senp6, sumo-specific protease, senp7, smt3ip1, ulp1 protease, sumo protease 1, sumo-specific protease 2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C48.001
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SENP2
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Small ubiquitin-related modifier protein 1 conjugate proteinase
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Smt3-protein conjugate proteinase
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SMT3IP1
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SMT3IP1/SENP3
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SUMO-specific protease
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SUMO-specific protease 2
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Ulp1
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Ulp1 endopeptidase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
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CAS REGISTRY NUMBER
COMMENTARY hide
252852-50-9
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
small ubiquitin-related modifier-Mdm2 + H2O
small ubiquitin-related modifier-protein + Mdm2
show the reaction diagram
small ubiquitin-related modifier-protein + H2O
small ubiquitin-related modifier-protein + protein
show the reaction diagram
-
SUMO-specific proteases, SENPs, reversibly remove small ubiquitin-related modifier-protein, SUMO, from the SUMOylated proteins
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r
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
small ubiquitin-related modifier-Mdm2 + H2O
small ubiquitin-related modifier-protein + Mdm2
show the reaction diagram
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co-localization of SENP2 with SUMO conjugated Mdm2. SUMO conjugation of Mdm2 induces its co-localization and association with SENP2 at the PML bodies
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r
small ubiquitin-related modifier-protein + H2O
small ubiquitin-related modifier-protein + protein
show the reaction diagram
-
SUMO-specific proteases, SENPs, reversibly remove small ubiquitin-related modifier-protein, SUMO, from the SUMOylated proteins
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r
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
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targeted disruption of SENP2 impairs the G-S transition required for mitotic and endoreupliation cell cycles during expansion of trophoblast stem cells and their differentiation into polyploidy cells, respectively. The disruption disturbs the subcellular distribution and SUMO modification of Mdm2, leading to interference with p53 degradation. SUMO conjugated Mdm2 is elevated in the SENP2-null cells
physiological function
additional information
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SUMO conjugation of Mdm2 induces its co-localization and association with SENP2 at the PML bodies
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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a genetic mutation inactivating all three gene products of SENP2 is generated by alternative splicing
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression of FLAG-SMT3IP1 in COS-7 cells, coexpression with His6-ubiquitin. Overexpression of SMT3IP1 in cells results in the accumulation of Mdm2 in the nucleolus and increased stability of the p53 protein
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expression of SENP1 and SENP2 isozymes in HCT-116 cells
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jiang, M.; Chiu, S.Y.; Hsu, W.
SUMO-specific protease 2 in Mdm2-mediated regulation of p53
Cell Death Differ.
18
1005-1015
2011
Mus musculus
Manually annotated by BRENDA team
Nishida, T.; Yamada, Y.
The nucleolar SUMO-specific protease SMT3IP1/SENP3 attenuates Mdm2-mediated p53 ubiquitination and degradation
Biochem. Biophys. Res. Commun.
406
285-291
2011
Mus musculus
Manually annotated by BRENDA team