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(2-aminobenzoyl)-Val-Ala-norLeu-Ser-Tyr(3-NO2)-Asp + H2O
?
-
ADZ 50,059
-
-
?
2-aminobenzoic acid-Val-Ala-Nle-Ser-(3-nitro)-tyrosinyl-aspartamide + H2O
?
-
-
-
-
?
alpha1-antitrypsin + H2O
?
-
recombinant Der p 1 previously activated with L-cysteine or DTT
-
-
?
azocasein + H2O
?
-
-
-
-
?
butyloxycarbonyl-Gln-Ala-Arg-4-methylcoumaryl-7-amide + H2O
butyloxycarbonyl-Gln-Ala-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
butyloxycarbonyl-Gln-Ala-Arg-7-amido-4-methylcoumarin + H2O
?
-
-
-
-
?
butyloxycarbonyl-Gln-Ala-Arg-7-amido-4-methylcoumarin + H2O
butyloxycarbonyl-Gln-Ala-Arg + 7-amino-4-methylcoumarin
butyloxycarbonyl-Gln-Ala-Arg-MCA + H2O
butyloxycarbonyl-Gln-Ala-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
butyloxycarbonyl-Gln-Gly-Arg-MCA + H2O
butyloxycarbonyl-Gln-Gly-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
butyloxycarbonyl-Phe-Ser-Arg-MCA + H2O
butyloxycarbonyl-Phe-Ser-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O
butyloxycarbonyl-Val-Leu-Lys + 7-amino-4-methylcoumarin
butyloxycarbonyl-Val-Leu-Lys-MCA + H2O
butyloxycarbonyl-Val-Leu-Lys + 7-amino-4-methylcoumarin
-
-
-
-
?
chestnut cystatin + H2O
?
-
specific proteolytic cleavage between Gly6 and Val7, giving rise to a noninhibitory processed protein. Not cleaved by Der f 1 from Dermatophygoides farinae
-
-
?
Der p 1 propiece + H2O
?
-
potent competitive inhibitor of Der p 1. The Der p 1 propiece behaves as a substrate and is fully degraded during this interaction. The rapid inactivation of Der p 1 prodomain is a mechanism that may contribute to the potency of this allergen
-
-
?
human alpha1-antitrypsin + H2O
?
-
cleaved by Der f 1-N53Q but not without its activation
-
-
?
lung surfactant protein A + H2O
?
lung surfactant protein D + H2O
?
mas-related G-protein-coupled receptor C11 + H2O
?
mas-related G-protein-coupled receptor X1 + H2O
?
human protein
-
-
?
N-Bz-Phe-Val-Arg-p-nitroanilide + H2O
?
-
-
-
-
?
N-succinyl-Ala-Pro-Ala-7-amido-4-methylcoumarin
N-succinyl-Ala-Pro-Ala + 7-amino-4-methylcoumarin
-
-
-
-
?
N-succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin
N-succinyl-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin
-
more efficiently hydrolyzed than N-succinyl-Ala-Pro-Ala-7-amido-4-methylcoumarin
-
-
?
N-succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
N-succinyl-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin
-
-
-
?
N-tert-butoxycarbonyl-Gln-Ala-Arg-7-amido-4-methylcoumarin + H2O
N-tert-butoxycarbonyl-Gln-Ala-Arg + 7-amino-4-methylcoumarin
pro-Der p 3 + H2O
Der p 3 + Der p 3 propeptide
pro-Der p 6 + H2O
Der p 6 + Der p 6 propeptide
pro-Der p 9 + H2O
Der p 9 + Der p 9 propeptide
succinyl-Leu-Leu-Val-Tyr-MCA + H2O
succinyl-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin
-
-
-
-
?
Z-Phe-Arg-4-methylcoumarin 7-amide + H2O
Z-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
additional information
?
-
Azocoll + H2O
?
-
collagen substrate
-
-
?
Azocoll + H2O
?
-
collagen substrate, Der f 1-N53Q proteolytically active
-
-
?
Azocoll + H2O
?
-
-
-
-
?
butyloxycarbonyl-Gln-Ala-Arg-7-amido-4-methylcoumarin + H2O
butyloxycarbonyl-Gln-Ala-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
butyloxycarbonyl-Gln-Ala-Arg-7-amido-4-methylcoumarin + H2O
butyloxycarbonyl-Gln-Ala-Arg + 7-amino-4-methylcoumarin
-
short synthetic substrate
-
-
?
butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O
butyloxycarbonyl-Val-Leu-Lys + 7-amino-4-methylcoumarin
-
-
-
-
?
butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O
butyloxycarbonyl-Val-Leu-Lys + 7-amino-4-methylcoumarin
-
more efficiently hydrolyzed than N-succinyl-Ala-Pro-Ala-7-amido-4-methylcoumarin
-
-
?
casein + H2O
?
-
-
-
-
?
CD23 + H2O
?
-
-
-
-
?
CD23 + H2O
?
-
CD23 is a calcium-dependent type II integral membrane protein. CD23 from the surface of cultured human B cells is cleaved at two sites: Ser155-Ser156 and Glu298-Ser299 to produce a 17000 Da fragment containing the lectin domain and only part of the C-terminal tail. No such effect is demonstrable with mouse CD23
-
-
?
CD23 + H2O
?
-
cleaves CD23 from the surface of cultured human B cells. The cleavage of the receptor from the B cell sulface is associated with a parallel increase in soluble CD23
-
-
?
CD23 + H2O
?
-
Der p 1 in addition to being highly immunogenic may up-regulate IgE synthesis by virtue of its ability to cleave CD23
-
-
?
CD23 + H2O
?
-
low-affinity IgE receptor
-
-
?
CD25 + H2O
?
-
-
-
-
?
CD25 + H2O
?
-
alpha-subunit of the IL-2 receptor
-
-
?
human CD23 + H2O
?
-
cleaved by Der f 1-N53Q and natural Der f 1 on the cell surface in a time- and dose dependent manner
-
-
?
human CD23 + H2O
?
-
human low-affinity IgE receptor
-
-
?
human CD25 + H2O
?
-
alpha subunit of the human IL-2 receptor
-
-
?
human CD25 + H2O
?
-
cleaved by Der f 1-N53Q and natural Der f 1 on the cell surface in a time- and dose dependent manner
-
-
?
lung surfactant protein A + H2O
?
-
-
-
-
?
lung surfactant protein A + H2O
?
-
degradation of lung surfactant protein A and lung surfactant protein D is associated with diminished binding to carbohydrates and to Dermatophagoides pteronyssinus allergen 1 itself and diminishes capacity to agglutinate bacteria. The degradation and consequent inactivation of lung surfactant protein A and lung surfactant protein D may be a novel mechanism to account for the potent allergenicity of the dust mite allergen
-
-
?
lung surfactant protein D + H2O
?
-
-
-
-
?
lung surfactant protein D + H2O
?
-
degradation of lung surfactant protein A and lung surfactant protein D is associated with diminished binding to carbohydrates and to Dermatophagoides pteronyssinus allergen 1 itself and diminishes capacity to agglutinate bacteria. The degradation and consequent inactivation of lung surfactant protein A and lung surfactant protein D may be a novel mechanism to account for the potent allergenicity of the dust mite allergen
-
-
?
mas-related G-protein-coupled receptor C11 + H2O
?
human protein
-
-
?
mas-related G-protein-coupled receptor C11 + H2O
?
mouse protein
-
-
?
N-tert-butoxycarbonyl-Gln-Ala-Arg-7-amido-4-methylcoumarin + H2O
N-tert-butoxycarbonyl-Gln-Ala-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
N-tert-butoxycarbonyl-Gln-Ala-Arg-7-amido-4-methylcoumarin + H2O
N-tert-butoxycarbonyl-Gln-Ala-Arg + 7-amino-4-methylcoumarin
-
-
-
?
N-tert-butoxycarbonyl-Gln-Ala-Arg-7-amido-4-methylcoumarin + H2O
N-tert-butoxycarbonyl-Gln-Ala-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
pro-Der p 3 + H2O
Der p 3 + Der p 3 propeptide
activation
-
-
?
pro-Der p 3 + H2O
Der p 3 + Der p 3 propeptide
activation, the enzyme Der p 1 cleaves the substrate between the P1 and P'1 positions of the activation site of the zymogen
-
-
?
pro-Der p 6 + H2O
Der p 6 + Der p 6 propeptide
activation
-
-
?
pro-Der p 6 + H2O
Der p 6 + Der p 6 propeptide
pro-Der p 6 zymogen is recombinantly produced in Pichia pastoris, activation mechanism analysis by mite protease Der p 1, overview. The enzyme Der p 1 cleaves the substrate between the P1 and P'1 positions of the activation site of the zymogen. The N-terminal sequence of rDer p 6 is V35IGGDQ. The propeptide of proDer p 6 inhibits the proteolytic activity of protease Der p 6, but once cleaved, it is degraded by the protease
-
-
?
pro-Der p 9 + H2O
Der p 9 + Der p 9 propeptide
activation
-
-
?
pro-Der p 9 + H2O
Der p 9 + Der p 9 propeptide
activation, the enzyme Der p 1 cleaves the substrate between the P1 and P'1 positions of the activation site of the zymogen
-
-
?
additional information
?
-
-
mature recombinant enzyme shows the same IgE binding activity as the native enzyme
-
-
?
additional information
?
-
-
allergen from Dermatophagoides farinae
-
-
?
additional information
?
-
-
recombinant Der f 1 activated with L-cysteine reduces the barrier function of the skin in dose- and time-dependent manners. The reduction is dependent on its proteolytic activity
-
-
?
additional information
?
-
development of a highly sensitive and specific fiber-optic chemifluorescent immunoassay (ELISA) for the detection of airborne enzyme allergen Der f1. The Der f1 concentration is measured on the basis of the intensity of fluorescence amplified by an enzymatic reaction between the labeled enzyme by a detection antibody and a fluorescent substrate 2,2'-azinobis [3-ethylbenzothiazoline-6-sulfonic acid]-diammonium salt of horse radish peroxidase, overview
-
-
?
additional information
?
-
-
development of a highly sensitive and specific fiber-optic chemifluorescent immunoassay (ELISA) for the detection of airborne enzyme allergen Der f1. The Der f1 concentration is measured on the basis of the intensity of fluorescence amplified by an enzymatic reaction between the labeled enzyme by a detection antibody and a fluorescent substrate 2,2'-azinobis [3-ethylbenzothiazoline-6-sulfonic acid]-diammonium salt of horse radish peroxidase, overview
-
-
?
additional information
?
-
-
Der p 1 is the most immunodominant allergen involved in the expression of dust mite-specific immunoglobulin (Ig)E-mediated hypersensitivity. The proteolytic activity of Der p 1 is a major contributor to its allergenicity. Cysteine protease activity of Der p 1 enhances total IgE production
-
-
?
additional information
?
-
-
cysteine protease activity of Der p 1 enhances total IgE production, apart from increasing Der p 1-specific IgE. This allergen may play a central role in destabilizing the micro-environment within target tissues to one that is pro-allergic, and thus aid in the initiation and propagation of the allergic cascade
-
-
?
additional information
?
-
-
the efficient in vivo responses, including production of IgE and IgG against the highly purified rDer p 1, are dependent on the cysteine protease activity in mice. The three types of rDer p 1 differing in function or structure elicit distinctly different immune responses
-
-
?
additional information
?
-
-
the house dust mite allergen Der p 1 stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated receptor-2-independent mechanism
-
-
?
additional information
?
-
-
house dust mite major allergens Der p 1 and Der p 5 activate human airway-derived epithelial cells by protease-dependent and protease-independent mechanisms
-
-
?
additional information
?
-
Der p 7 binds a bacterially-derived lipid product, a common feature of some allergens, ligand binding analysis by NMR analysis
-
-
?
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(3S)-3-([N-[(2S)-3,3-dimethyl-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanoyl]-L-alanyl]amino)-4-methyl-2-oxo-N-(4-sulfamoylbenzyl)pentanamide
-
(3S)-N-benzyl-3-([N-[(2S)-3,3-dimethyl-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanoyl]-L-alanyl]amino)-4-methyl-2-oxopentanamide
-
(3S)-N-[4-[(dimethylamino)methyl]benzyl]-3-([N-[(2S)-3,3-dimethyl-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanoyl]-L-alanyl]amino)-4-methyl-2-oxopentanamide
-
3-methyl-N-(naphthalen-1-ylcarbonyl)-L-valyl-N-[(3S)-1-(cyclohexylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
-
3-methyl-N-(pyridin-4-ylcarbonyl)-L-valyl-N-[(3S)-1-(cyclohexylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
-
3-methyl-N-(quinolin-4-ylcarbonyl)-L-valyl-N-[(3S)-1-(benzylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
-
3-methyl-N-(quinolin-4-ylcarbonyl)-L-valyl-N-[(3S)-1-(cyclohexylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
-
3-methyl-N-(quinolin-4-ylcarbonyl)-L-valyl-N-[(3S)-4-methyl-1,2-dioxo-1-([2-oxo-2-[4-(propan-2-yl)piperazin-1-yl]ethyl]amino)pentan-3-yl]-L-alaninamide
-
3-methyl-N-[(1-methylpiperidin-4-yl)carbonyl]-L-valyl-N-[(3S)-1-(benzylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
-
4-(2-aminoethyl) benzenesulfonyl fluoride
-
4-([[(3S)-3-([N-[(2S)-3,3-dimethyl-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanoyl]-L-alanyl]amino)-4-methyl-2-oxopentanoyl]amino]methyl)-N-methylbenzamide
-
chestnut cystatin
-
inhibits the enzyme and greatly increases the larval mortality
-
Der p 1 allergen
-
ADZ 50,000, irreversible inactivation, active site titrant
-
Der p 1 prodomain
-
PP-02, recombinant, apparently competitive
-
Der p 1 propeptide
the propeptide of 80 amino acids plays an essential role in zymogen folding (as an intramolecular chaperone) and in the inhibition of its own enzymatic activity
-
Der p 1 propiece
-
potent competitive inhibitor of Der p 1. The Der p 1 propiece behaves as a substrate and is fully degraded during this interaction
-
N-(naphthalen-1-ylcarbonyl)-L-phenylalanyl-N-[(3S)-4-methyl-1-[[2-(4-methylpiperazin-1-yl)-2-oxoethyl]amino]-1,2-dioxopentan-3-yl]-L-alaninamide
-
N-benzoyl-3-methyl-L-valyl-N-[(3S)-1-(benzylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
-
N-benzoyl-3-methyl-L-valyl-N-[(3S)-1-(cyclohexylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
-
N-benzoyl-3-methyl-L-valyl-N-[(3S)-1-(cyclopropylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
-
N-benzoyl-3-methyl-L-valyl-N-[(3S)-1-([4-[(dimethylamino)methyl]benzyl]amino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
-
N-benzoyl-3-methyl-L-valyl-N-[(3S)-1-amino-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
-
N-benzoyl-3-methyl-L-valyl-N-[(3S)-4-methyl-1,2-dioxo-1-[(1H-pyrazol-4-ylmethyl)amino]pentan-3-yl]-L-alaninamide
-
N-benzoyl-3-methyl-L-valyl-N-[(3S)-4-methyl-1,2-dioxo-1-[(4-sulfamoylbenzyl)amino]pentan-3-yl]-L-alaninamide
-
N-benzoyl-3-methyl-L-valyl-N-[(3S)-4-methyl-1,2-dioxo-1-[[(1R)-1-phenylethyl]amino]pentan-3-yl]-L-alaninamide
-
N-benzoyl-3-methyl-L-valyl-N-[(3S)-4-methyl-1,2-dioxo-1-[[(1S)-1-phenylethyl]amino]pentan-3-yl]-L-alaninamide
-
N-benzoyl-3-methyl-L-valyl-N-[(3S)-4-methyl-1,2-dioxo-1-[[4-(trifluoromethyl)benzyl]amino]pentan-3-yl]-L-alaninamide
-
N-benzoyl-3-methyl-L-valyl-N-[(3S)-4-methyl-1-(methylamino)-1,2-dioxopentan-3-yl]-L-alaninamide
-
N-benzoyl-3-methyl-L-valyl-N-[(3S)-4-methyl-1-[[2-(4-methylpiperazin-1-yl)-2-oxoethyl]amino]-1,2-dioxopentan-3-yl]-L-alaninamide
-
N-benzoyl-b,b-dimethyl-L-phenylalanyl-N-[(3S)-1-(benzylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
-
N-benzoyl-L-phenylalanyl-N-[(3S)-1,2-dioxo-1-(pyrrolidin-1-yl)heptan-3-yl]-L-alaninamide
-
N-benzoyl-L-phenylalanyl-N-[(3S)-1-(benzylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
-
N-benzoyl-L-phenylalanyl-N-[(3S)-1-(cyclohexylamino)-1,2-dioxoheptan-3-yl]-L-alaninamide
-
N-benzoyl-L-phenylalanyl-N-[(3S)-1-(cyclohexylamino)-4,4-dimethyl-1,2-dioxopentan-3-yl]-L-alaninamide
-
N-benzoyl-L-phenylalanyl-N-[(3S)-1-(cyclohexylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
-
N-benzoyl-L-phenylalanyl-N-[(3S)-1-(cyclohexylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-norvalinamide
-
N-benzoyl-L-phenylalanyl-N-[(3S)-1-[[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]amino]-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
-
N-benzoyl-L-phenylalanyl-N-[(3S)-1-[[2-(4,4-dimethylpiperazin-4-ium-1-yl)-2-oxoethyl]amino]-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
-
N-benzoyl-L-phenylalanyl-N-[(3S)-2-oxo-1-(pyrrolidin-1-yl)heptan-3-yl]-L-alaninamide
-
N-benzoyl-L-phenylalanyl-N-[(3S)-4-methyl-1,2-dioxo-1-(tetrahydro-2H-pyran-4-ylamino)pentan-3-yl]-L-alaninamide
-
N-benzoyl-L-phenylalanyl-N-[(3S)-4-methyl-1,2-dioxo-1-([2-oxo-2-[4-(propan-2-yl)piperazin-1-yl]ethyl]amino)pentan-3-yl]-L-alaninamide
-
N-benzoyl-L-phenylalanyl-N-[(3S)-4-methyl-1,2-dioxo-1-[[2-oxo-2-(piperidin-1-yl)ethyl]amino]pentan-3-yl]-L-alaninamide
-
N-benzoyl-L-phenylalanyl-N-[(3S)-4-methyl-1-[(1-methylpiperidin-4-yl)amino]-1,2-dioxopentan-3-yl]-L-alaninamide
-
N-benzoyl-L-phenylalanyl-N-[(3S)-4-methyl-1-[[(2S)-1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl]amino]-1,2-dioxopentan-3-yl]-L-alaninamide
-
N-benzoyl-L-phenylalanyl-N-[(3S)-4-methyl-1-[[2-(4-methylpiperazin-1-yl)-2-oxoethyl]amino]-1,2-dioxopentan-3-yl]-L-alaninamide
-
N-benzoyl-L-phenylalanyl-N-[(3S)-4-methyl-1-[[2-(morpholin-4-yl)-2-oxoethyl]amino]-1,2-dioxopentan-3-yl]-L-alaninamide
-
N-benzoyl-L-valyl-N-[(3S)-1-(benzoyloxy)-2-oxoheptan-3-yl]-L-alaninamide
irreversible inhibitor
N-[(1,1-dimethylpiperidinium-4-yl)carbonyl]-3-methyl-L-valyl-N-[(3S)-1-(benzylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
-
N-[(1S)-2-[[(2S)-1-[[(3S)-4-methyl-1-[[2-(4-methylpiperazin-1-yl)-2-oxoethyl]amino]-1,2-dioxopentan-3-yl]amino]-1-oxopropan-2-yl]amino]-2-oxo-1-(tricyclo[3.3.1.13,7]dec-1-yl)ethyl]benzamide
-
N-[(3,5-dimethyl-1H-pyrazol-4-yl)carbonyl]-3-methyl-L-valyl-N-[(3S)-1-(benzylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
-
phenylmethanesulfonyl fluoride
-
PTL11028
-
a highly potent and specific inhibitor, being effective against both purified protease and Der p 1 within HDM extract
cystatin A
-
sweat inhibitor, upregulation of IL-8 secretion by stimulation of human keratinocytes by Der f 1 is blocked
-
E-64
-
-
E-64
-
cysteine protease specific inhibitor
E-64
-
irreversible inhibition, cysteine protease-specific
E-64
-
trans-epoxysuccinyl L-leucylamido (4-guanidine) butane, 0.01 mM, complete inhibition of interleukine production in A549 epithelial cells
E-64
-
cysteine protease-specific inhibitor, complete inhibition
E-64
-
cysteine protease-specific inhibitor
E-64
cysteine protease-specific inhibitor, 0.1 mM, complete inhibition
additional information
-
Der f1 from Dermatophagoides farinae is highly susceptible, Der p 1 from Dermatophagoides pteronyssinus is not affected by chestnut cystatin. Der p 1 inactivates chestnut chystatin by a specific proteolytic cleavage between Gly6 and Val7
-
additional information
-
not inhibited by AEBSF
-
additional information
inhibition efficiency in vivo, overview
-
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0.000003
(3S)-3-([N-[(2S)-3,3-dimethyl-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanoyl]-L-alanyl]amino)-4-methyl-2-oxo-N-(4-sulfamoylbenzyl)pentanamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000007
(3S)-N-benzyl-3-([N-[(2S)-3,3-dimethyl-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanoyl]-L-alanyl]amino)-4-methyl-2-oxopentanamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000004
(3S)-N-[4-[(dimethylamino)methyl]benzyl]-3-([N-[(2S)-3,3-dimethyl-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanoyl]-L-alanyl]amino)-4-methyl-2-oxopentanamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.00002
3-methyl-N-(naphthalen-1-ylcarbonyl)-L-valyl-N-[(3S)-1-(cyclohexylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000013
3-methyl-N-(pyridin-4-ylcarbonyl)-L-valyl-N-[(3S)-1-(cyclohexylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000018
3-methyl-N-(quinolin-4-ylcarbonyl)-L-valyl-N-[(3S)-1-(benzylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000013
3-methyl-N-(quinolin-4-ylcarbonyl)-L-valyl-N-[(3S)-1-(cyclohexylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000003
3-methyl-N-(quinolin-4-ylcarbonyl)-L-valyl-N-[(3S)-4-methyl-1,2-dioxo-1-([2-oxo-2-[4-(propan-2-yl)piperazin-1-yl]ethyl]amino)pentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.00019
3-methyl-N-[(1-methylpiperidin-4-yl)carbonyl]-L-valyl-N-[(3S)-1-(benzylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000004
4-([[(3S)-3-([N-[(2S)-3,3-dimethyl-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanoyl]-L-alanyl]amino)-4-methyl-2-oxopentanoyl]amino]methyl)-N-methylbenzamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000051 - 0.0000569
Der p 1 prodomain
-
0.00002
N-(naphthalen-1-ylcarbonyl)-L-phenylalanyl-N-[(3S)-4-methyl-1-[[2-(4-methylpiperazin-1-yl)-2-oxoethyl]amino]-1,2-dioxopentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000009
N-benzoyl-3-methyl-L-valyl-N-[(3S)-1-(benzylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000014
N-benzoyl-3-methyl-L-valyl-N-[(3S)-1-(cyclohexylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000017
N-benzoyl-3-methyl-L-valyl-N-[(3S)-1-(cyclopropylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000008
N-benzoyl-3-methyl-L-valyl-N-[(3S)-1-([4-[(dimethylamino)methyl]benzyl]amino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000006
N-benzoyl-3-methyl-L-valyl-N-[(3S)-1-amino-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000011
N-benzoyl-3-methyl-L-valyl-N-[(3S)-4-methyl-1,2-dioxo-1-[(1H-pyrazol-4-ylmethyl)amino]pentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000006
N-benzoyl-3-methyl-L-valyl-N-[(3S)-4-methyl-1,2-dioxo-1-[(4-sulfamoylbenzyl)amino]pentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000117
N-benzoyl-3-methyl-L-valyl-N-[(3S)-4-methyl-1,2-dioxo-1-[[(1R)-1-phenylethyl]amino]pentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000017
N-benzoyl-3-methyl-L-valyl-N-[(3S)-4-methyl-1,2-dioxo-1-[[(1S)-1-phenylethyl]amino]pentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000047
N-benzoyl-3-methyl-L-valyl-N-[(3S)-4-methyl-1,2-dioxo-1-[[4-(trifluoromethyl)benzyl]amino]pentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000024
N-benzoyl-3-methyl-L-valyl-N-[(3S)-4-methyl-1-(methylamino)-1,2-dioxopentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000014
N-benzoyl-3-methyl-L-valyl-N-[(3S)-4-methyl-1-[[2-(4-methylpiperazin-1-yl)-2-oxoethyl]amino]-1,2-dioxopentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000042
N-benzoyl-b,b-dimethyl-L-phenylalanyl-N-[(3S)-1-(benzylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000997
N-benzoyl-L-phenylalanyl-N-[(3S)-1,2-dioxo-1-(pyrrolidin-1-yl)heptan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000012
N-benzoyl-L-phenylalanyl-N-[(3S)-1-(benzylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000008 - 0.000017
N-benzoyl-L-phenylalanyl-N-[(3S)-1-(cyclohexylamino)-1,2-dioxoheptan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.00917
N-benzoyl-L-phenylalanyl-N-[(3S)-1-(cyclohexylamino)-4,4-dimethyl-1,2-dioxopentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000018
N-benzoyl-L-phenylalanyl-N-[(3S)-1-(cyclohexylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000164
N-benzoyl-L-phenylalanyl-N-[(3S)-1-(cyclohexylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-norvalinamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000006
N-benzoyl-L-phenylalanyl-N-[(3S)-1-[[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]amino]-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000017
N-benzoyl-L-phenylalanyl-N-[(3S)-1-[[2-(4,4-dimethylpiperazin-4-ium-1-yl)-2-oxoethyl]amino]-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000065
N-benzoyl-L-phenylalanyl-N-[(3S)-2-oxo-1-(pyrrolidin-1-yl)heptan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000055
N-benzoyl-L-phenylalanyl-N-[(3S)-4-methyl-1,2-dioxo-1-(tetrahydro-2H-pyran-4-ylamino)pentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000004
N-benzoyl-L-phenylalanyl-N-[(3S)-4-methyl-1,2-dioxo-1-([2-oxo-2-[4-(propan-2-yl)piperazin-1-yl]ethyl]amino)pentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000014
N-benzoyl-L-phenylalanyl-N-[(3S)-4-methyl-1,2-dioxo-1-[[2-oxo-2-(piperidin-1-yl)ethyl]amino]pentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000115
N-benzoyl-L-phenylalanyl-N-[(3S)-4-methyl-1-[(1-methylpiperidin-4-yl)amino]-1,2-dioxopentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.00001
N-benzoyl-L-phenylalanyl-N-[(3S)-4-methyl-1-[[(2S)-1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl]amino]-1,2-dioxopentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000014
N-benzoyl-L-phenylalanyl-N-[(3S)-4-methyl-1-[[2-(4-methylpiperazin-1-yl)-2-oxoethyl]amino]-1,2-dioxopentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000009
N-benzoyl-L-phenylalanyl-N-[(3S)-4-methyl-1-[[2-(morpholin-4-yl)-2-oxoethyl]amino]-1,2-dioxopentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000006
N-[(1,1-dimethylpiperidinium-4-yl)carbonyl]-3-methyl-L-valyl-N-[(3S)-1-(benzylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000005
N-[(1S)-2-[[(2S)-1-[[(3S)-4-methyl-1-[[2-(4-methylpiperazin-1-yl)-2-oxoethyl]amino]-1,2-dioxopentan-3-yl]amino]-1-oxopropan-2-yl]amino]-2-oxo-1-(tricyclo[3.3.1.13,7]dec-1-yl)ethyl]benzamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000067
N-[(3,5-dimethyl-1H-pyrazol-4-yl)carbonyl]-3-methyl-L-valyl-N-[(3S)-1-(benzylamino)-4-methyl-1,2-dioxopentan-3-yl]-L-alaninamide
Dermatophagoides pteronyssinus
pH and temperature not specified in the publication
0.000051
Der p 1 prodomain
Dermatophagoides pteronyssinus
-
recombinant Der p 1, expressed in Pichia pastoris
-
0.0000569
Der p 1 prodomain
Dermatophagoides pteronyssinus
-
Der p 1 purified from Dermatophagoides pteronyssinus
-
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Pernas, M.; Sanchez-Ramos, I.; Sanchez-Monge, R.; Lombardero, M.; Arteaga, C.; Castanera, P.; Salcedo, G.
Der p 1 and Der f 1, the highly related and major allergens from house dust mites, are differentially affected by a plant cystatin
Clin. Exp. Allergy
30
972-978
2000
Dermatophagoides farinae, Dermatophagoides pteronyssinus
brenda
Takai, T.; Mineki, R.; Nakazawa, T.; Takaoka, M.; Yasueda, H.; Murayama, K.; Okumura, K.; Ogawa, H.
Maturation of the activities of recombinant mite allergens Der p 1 and Der f 1, and its implication in the blockade of proteolytic activity
FEBS Lett.
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2002
Dermatophagoides farinae, Dermatophagoides pteronyssinus
brenda
Yasuhara, T.; Takai, T.; Yuuki, T.; Okudaira, H.; Okumura, Y.
Biologically active recombinant forms of a major house dust mite group 1 allergen Der f 1 with full activities of both cysteine protease and IgE binding
Clin. Exp. Allergy
31
116-124
2001
Dermatophagoides farinae
brenda
Shoji, H.; Shibuya, I.; Hirai, M.; Horiuchi, H.; Takagi, M.
Production of recombinant Der f1 with the native IgE-binding activity using a baculovirus expression system
Biosci. Biotechnol. Biochem.
61
1668-1673
1997
Dermatophagoides farinae
brenda
Shoji, H.; Hanawa, M.; Shibuya, I.; Hirai, M.; Yasuhara, T.; Okumura, Y.; Yamakawa, H.
Production of recombinant mite allergen Der f1 in insect cells and characterization of products
Biosci. Biotechnol. Biochem.
60
621-625
1996
Dermatophagoides farinae
brenda
Shoji, H.; Horiuchi, H.; Takagi, M.
Production of recombinant Der f1 (a major mite allergen) by Aspergillus oryzae
Biosci. Biotechnol. Biochem.
63
703-709
1999
Dermatophagoides farinae
brenda
Takahashi, K.; Takai, T.; Yasuhara, T.; Yuuki, T.; Ohtake, Y.; Yokota, T.; Okumura, Y.
Production of enzymatically and immunologically active Der f1 in Escherichia coli
Int. Arch. Allergy Immunol.
122
108-114
2000
Dermatophagoides farinae
brenda
Takahashi, K.; Takai, T.; Yasuhara, T.; Yokota, T.; Okumura, Y.
Effects of site-directed mutagenesis in the cysteine residues and the N-glycosylation motif in recombinant Der f1 on secretion and protease activity
Int. Arch. Allergy Immunol.
124
454-460
2001
Dermatophagoides farinae
brenda
Thomas, W.R.; Stewart, G.A.; Simpson, R.J.; Chua, K.Y.; Plozza, T.M.; Dilworth, R.J.; Nisbet, A.; Turner, K.J.
Cloning and expression of DNA coding for the major house dust mite allergen Der p 1 in Escherichia coli
Int. Arch. Allergy Appl. Immunol.
85
127-129
1988
Dermatophagoides pteronyssinus (P08176)
brenda
Gough, L.; Schulz, O.; Sewell, H.F.; Shakib, F.
The cysteine protease activity of the major dust mite allergen Der p 1 selectively enhances the immunoglobulin E antibody response
J. Exp. Med.
190
1897-1902
1999
Dermatophagoides pteronyssinus
brenda
Schulz, O.; Sutton, B.J.; Beavil, R.L.; Shi, J.; Sewell, H.F.; Gould, H.J.; Laing, P.; Shakib, F.
Cleavage of the low-affinity receptor for human IgE (CD23) by a mite cysteine protease: nature of the cleaved fragment in relation to the structure and function of CD23
Eur. J. Immunol.
27
584-588
1997
Dermatophagoides pteronyssinus
brenda
Schulz, O.; Laing, P.; Sewell, H.F.; Shakib, F.
Der p I, a major allergen of the house dust mite, proteolytically cleaves the low-affinity receptor for human IgE (CD23)
Eur. J. Immunol.
25
3191-3194
1995
Dermatophagoides pteronyssinus
brenda
Shakib, F.; Gough, L.
The proteolytic activity of Der p 1 selectively enhances IgE synthesis: a link between allergenicity and cysteine protease activity
Clin. Exp. Allergy
30
751-752
2000
Dermatophagoides pteronyssinus
brenda
John, R.J.; Rusznak, C.; Ramjee, M.; Lamont, A.G.; Abrahamson, M.; Hewitt, E.L.
Functional effects of the inhibition of the cysteine protease activity of the major house dust mite allergen Der p 1 by a novel peptide-based inhibitor
Clin. Exp. Allergy
30
784-793
2000
Dermatophagoides pteronyssinus
brenda
Takai, T.; Kato, T.; Sakata, Y.; Yasueda, H.; Izuhara, K.; Okumura, K.; Ogawa, H.
Recombinant Der p 1 and Der f 1 exhibit cysteine protease activity but no serine protease activity
Biochem. Biophys. Res. Commun.
328
944-952
2005
Dermatophagoides pteronyssinus
brenda
Kauffman Henk , K.H.; Tamm Michae, T.M.; Timmerman J. Andre , T.J.; Borger Pete, B.P.
House dust mite major allergens Der p 1 and Der p 5 activate human airway-derived epithelial cells by protease-dependent and protease-independent mechanisms
Clin. Mol. Allergy
4
5-5
2006
Dermatophagoides pteronyssinus
brenda
Takai, T.; Kato, T.; Ota, M.; Yasueda, H.; Kuhara, T.; Okumura, K.; Ogawa, H.
Recombinant Der p 1 and Der f 1 with in vitro enzymatic activity to cleave human CD23, CD25 and alpha1-antitrypsin, and in vivo IgE-eliciting activity in mice
Int. Arch. Allergy Immunol.
137
194-200
2005
Dermatophagoides farinae, Dermatophagoides pteronyssinus
brenda
Takai, T.; Mizuuchi, E.; Kikuchi, Y.; Nagamune, T.; Okumura, K.; Ogawa, H.
Glycosylation of recombinant proforms of major house dust mite allergens Der p 1 and Der f 1 decelerates the speed of maturation
Int. Arch. Allergy Immunol.
139
181-187
2006
Dermatophagoides pteronyssinus
brenda
Wong, C.K.; Li, M.L.; Wang, C.B.; Ip, W.K.; Tian, Y.P.; Lam, C.W.
House dust mite allergen Der p 1 elevates the release of inflammatory cytokines and expression of adhesion molecules in co-culture of human eosinophils and bronchial epithelial cells
Int. Immunol.
18
1327-1335
2006
Dermatophagoides pteronyssinus
brenda
Takai, T.; Kato, T.; Yasueda, H.; Okumura, K.; Ogawa, H.
Analysis of the structure and allergenicity of recombinant pro- and mature Der p 1 and Der f 1: Major conformational IgE epitopes blocked by prodomains
J. Allergy Clin. Immunol.
115
555-563
2005
Dermatophagoides farinae, Dermatophagoides pteronyssinus
brenda
Pichavant, M.; Charbonnier, A.; Taront, S.; Brichet, A.; Wallaert, B.; Pestel, J.; Tonnel, A.; Gosset, P.
Asthmatic bronchial epithelium activated by the proteolytic allergen Der p 1 increases selective dendritic cell recruitment
J. Allergy Clin. Immunol.
115
771-778
2005
Dermatophagoides pteronyssinus
brenda
de Halleux, S.; Stura, E.; VanderElst, L.; Carlier, V.; Jacquemin, M.; Saint-Remy, J.
Three-dimensional structure and IgE-binding properties of mature fully active Der p 1, a clinically relevant major allergen
J. Allergy Clin. Immunol.
117
571-576
2006
Dermatophagoides pteronyssinus, Dermatophagoides pteronyssinus (P08176)
brenda
Adam, E.; Hansen, K.K.; Astudillo, O.F.; Coulon, L.; Bex, F.; Duhant, X.; Jaumotte, E.; Hollenberg, M.D.; Jacquet, A.
The house dust mite allergen Der p 1, unlike Der p 3, stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated receptor-2-independent mechanism
J. Biol. Chem.
281
6910-6923
2006
Dermatophagoides pteronyssinus
brenda
Tempels-Pavlica, Z.; Oosting, A.J.; Terreehorst, I.; van Wijk, R.G.; Bruijnzeel-Koomen, C.A.; de Monchy, J.G.; Aalberse, R.C.
Differential effect of mattress covers on the level of Der p 1 and Der f 1 in dust
Clin. Exp. Allergy
34
1444-1447
2004
Dermatophagoides farinae
brenda
Kato, T.; Takai, T.; Mitsuishi, K.; Okumura, K.; Ogawa, H.
Cystatin A inhibits IL-8 production by keratinocytes stimulated with Der p 1 and Der f 1: biochemical skin barrier against mite cysteine proteases
J. Allergy Clin. Immunol.
116
169-176
2005
Dermatophagoides farinae
brenda
Perfetti, L.; Ferrari, M.; Galdi, E.; Pozzi, V.; Cottica, D.; Grignani, E.; Minoia, C.; Moscato, G.
House dust mites (Der p 1, Der f 1), cat (Fel d 1) and cockroach (Bla g 2) allergens in indoor work-places (offices and archives)
Sci. Total Environ.
328
15-21
2004
Dermatophagoides farinae
brenda
Zhang, J.; Hamilton, J.M.; Garrod, D.R.; Robinson, C.
Interactions between mature Der p 1 and its free prodomain indicate membership of a new family of C1 peptidases
Allergy
62
1302-1309
2007
Dermatophagoides pteronyssinus
brenda
Meno Kar, M.K.; Thorsted Peter , T.P.; Ipsen Henri, I.H.; Kristensen Ol, K.O.; Larsen Jorgen , L.J.; Spangfort Michael , S.M.; Gajhede Michae, G.M.; Lund Kaar, L.K.
The metal binding site of the major house dust mite allergen Der p 1
J. Allergy Clin. Immunol.
118
971-971
2006
Dermatophagoides pteronyssinus (P08176)
brenda
Deb, R.; Shakib, F.; Reid, K.; Clark, H.
Major house dust mite allergens Dermatophagoides pteronyssinus 1 and Dermatophagoides farinae 1 degrade and inactivate lung surfactant proteins A and D
J. Biol. Chem.
282
36808-36819
2007
Dermatophagoides pteronyssinus
brenda
Kikuchi, Y.; Takai, T.; Kuhara, T.; Ota, M.; Kato, T.; Hatanaka, H.; Ichikawa, S.; Tokura, T.; Akiba, H.; Mitsuishi, K.; Ikeda, S.; Okumura, K.; Ogawa, H.
Crucial commitment of proteolytic activity of a purified recombinant major house dust mite allergen Der p1 to sensitization toward IgE and IgG responses
J. Immunol.
177
1609-1617
2006
Dermatophagoides pteronyssinus
brenda
Nakamura, T.; Hirasawa, Y.; Takai, T.; Mitsuishi, K.; Okuda, M.; Kato, T.; Okumura, K.; Ikeda, S.; Ogawa, H.
Reduction of skin barrier function by proteolytic activity of a recombinant house dust mite major allergen Der f 1
J. Invest. Dermatol.
126
2719-2723
2006
Dermatophagoides farinae
brenda
Szalai, K.; Fuhrmann, J.; Pavkov, T.; Scheidl, M.; Wallmann, J.; Braemswig, K.H.; Vrtala, S.; Scheiner, O.; Keller, W.; Saint-Remy, J.M.; Neumann, D.; Pali-Schoell, I.; Jensen-Jarolim, E.
Mimotopes identify conformational B-cell epitopes on the two major house dust mite allergens Der p 1 and Der p 2
Mol. Immunol.
45
1308-1317
2008
Dermatophagoides pteronyssinus
brenda
Lienard, D.; Tran Dinh, O.; van Oort, E.; Van Overtvelt, L.; Bonneau, C.; Wambre, E.; Bardor, M.; Cosette, P.; Didier-Laurent, A.; de Borne, F.D.; Delon, R.; van Ree, R.; Moingeon, P.; Faye, L.; Gomord, V.
Suspension-cultured BY-2 tobacco cells produce and mature immunologically active house dust mite allergens
Plant Biotechnol. J.
5
93-108
2007
Dermatophagoides pteronyssinus
brenda
Zhang, J.; Saint-Remy, J.M.; Garrod, D.R.; Robinson, C.
Comparative enzymology of native and recombinant house dust mite allergen Der p 1
Allergy
64
469-477
2009
Dermatophagoides pteronyssinus
brenda
Cui, Y.; Zhou, P.; Peng, J.; Peng, M.; Zhou, Y.; Lin, Y.; Liu, L.
Cloning, sequence analysis, and expression of cDNA coding for the major house dust mite allergen, Der f 1, in Escherichia coli
Braz. J. Med. Biol. Res.
41
380-388
2008
Dermatophagoides farinae (Q58A71), Dermatophagoides farinae
brenda
Walgraffe, D.; Matteotti, C.; El Bakkoury, M.; Garcia, L.; Marchand, C.; Bullens, D.; Vandenbranden, M.; Jacquet, A.
A hypoallergenic variant of Der p 1 as a candidate for mite allergy vaccines
J. Allergy Clin. Immunol.
123
1150-1156
2009
Dermatophagoides pteronyssinus
brenda
Maneechotesuwan, K.; Wamanuttajinda, V.; Kasetsinsombat, K.; Huabprasert, S.; Yaikwawong, M.; Barnes, P.J.; Wongkajornsilp, A.
Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite-sensitive patients with asthma
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Dermatophagoides farinae, Dermatophagoides pteronyssinus
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Major mite allergen Der f 1 concentration is reduced in buildings with improved energy performance
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Dermatophagoides farinae, Dermatophagoides pteronyssinus
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Asturias, J.A.; Ibarrola, I.; Arilla, M.C.; Vidal, C.; Ferrer, A.; Gamboa, P.M.; Vinuela, J.E.; Sanz, M.L.; Andreu, C.; Martinez, A.
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Dermatophagoides pteronyssinus
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Horlock, C.; Shakib, F.; Jones, N.S.; Sewell, H.F.; Ghaemmaghami, A.M.
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Dermatophagoides farinae, Dermatophagoides pteronyssinus
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Dermatophagoides pteronyssinus (P49273), Dermatophagoides pteronyssinus
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Herman, J.; Thelen, N.; Smargiasso, N.; Mailleux, A.C.; Luxen, A.; Cloes, M.; De Pauw, E.; Chevigne, A.; Galleni, M.; Dumez, M.E.
Der p 1 is the primary activator of Der p 3, Der p 6 and Der p 9 the proteolytic allergens produced by the house dust mite Dermatophagoides pteronyssinus
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Dermatophagoides pteronyssinus (P08176), Dermatophagoides pteronyssinus
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Dermatophagoides pteronyssinus (P08176), Dermatophagoides farinae (Q58A71)
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Dermatophagoides pteronyssinus (P08176)
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Newton, G.K.; Perrior, T.R.; Jenkins, K.; Major, M.R.; Key, R.E.; Stewart, M.R.; Firth-Clark, S.; Lloyd, S.M.; Zhang, J.; Francis-Newton, N.J.; Richardson, J.P.; Chen, J.; Lai, P.; Garrod, D.R.; Robinson, C.
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Dermatophagoides pteronyssinus (P08176)
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The glycosylation pattern of common allergens: The recognition and uptake of Der p 1 by epithelial and dendritic cells is carbohydrate dependent
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Dermatophagoides pteronyssinus (P08176)
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Dermatophagoides farinae (P16311)
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Miyajima, K.; Suzuki, Y.; Miki, D.; Arai, M.; Arakawa, T.; Shimomura, H.; Shiba, K.; Mitsubayashi, K.
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Marconi, G.; Albertini, E.; Mari, A.; Palazzo, P.; Porceddu, A.; Raggi, L.; Bolis, L.; Lancioni, H.; Palomba, A.; Lucentini, L.; Lanfaloni, L.; Marcucci, F.; Falcinelli, M.; Panara, F.
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Dermatophagoides pteronyssinus (B5AYU7), Dermatophagoides pteronyssinus
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Reddy, V.B.; Lerner, E.A.
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Dermatophagoides farinae (P16311)
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