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26S protease regulatory subunit 4 + H2O
?
-
SwissProt: P62192 M
-
-
?
26S protease regulatory subunit 7 + H2O
?
-
SwissProt: P35998
-
-
?
26S proteasome subunit + H2O
?
-
during apoptosis, the activated caspase-7 directly cleaves certain subunits of 26S proteasomes, which then result in a decline in the proteasomal activity
-
-
?
Ac-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin + H2O
Ac-Asp-Glu-Val-Asp + 7-amino-4-methylcoumarin
-
a caspase-3 substrate
-
-
?
Ac-DEVD-4-nitroanilide + H2O
Ac-DEVD + 4-nitroaniline
-
-
-
-
?
Ac-DEVD-7-amido-4-methylcoumarin + H2O
Ac-DEVD + 7-amino-4-methylcoumarin
Ac-DEVD-p-nitroanilide + H2O
p-nitroaniline + Ac-DEVD
-
-
-
-
?
Ac-DQTD-7-amido-4-methylcoumarin + H2O
Ac-DQTD + 7-amino-4-methylcoumarin
-
-
-
-
?
Ac-DVAD-p-nitroanilide + H2O
p-nitroaniline + Ac-DVAD
-
-
-
-
?
Ac-LDVAD-p-nitroanilide + H2O
p-nitroaniline + Ac-LDVAD
-
-
-
-
?
Ac-VDVAD-p-nitroanilide + H2O
p-nitroaniline + Ac-VDVAD
-
-
-
-
?
Ac-VEID-7-amido-4-methylcoumarin + H2O
Ac-VEID + 7-amino-4-methylcoumarin
-
-
-
?
acetyl-Asp-Glu-Val-Asp-p-nitroanilide + H2O
acetyl-Asp-Glu-Val-Asp + p-nitroaniline
-
-
-
-
?
acetyl-DEVD-4-nitroanilide + H2O
acetyl-DEVD + 4-nitroaniline
-
-
-
-
?
acetyl-DEVD-7-amido-4-fluoromethylcoumarin + H2O
acetyl-DEVD + 7-amino-4-fluoromethylcoumarin
-
-
-
-
?
acetyl-DEVD-7-amido-4-methylcoumarin + H2O
acetyl-DEVD + 7-amino-4-methylcoumarin
-
iDEVD s the optimal tetrapeptide recognition motif
-
-
?
acetyl-DQMD-4-nitroanilide + H2O
acetyl-DQMD + 4-nitroaniline
-
-
-
-
?
acetyl-VDQQD-4-nitroanilide + H2O
acetyl-VDQQD + 4-nitroaniline
-
-
-
-
?
acetyl-VDQVDGW-amide + H2O
?
-
preferred peptide substrate
-
-
?
acetyl-VDVAD-4-nitroanilide + H2O
acetyl-VAVAD + 4-nitroaniline
-
-
-
-
?
acetyl-VEID-4-nitroanilide + H2O
acetyl-VEID + 4-nitroaniline
-
-
-
-
?
acetyl-VQVD-4-nitroanilide + H2O
acetyl-VQVD + 4-nitroaniline
-
-
-
-
?
acetyl-VQVDGW-amide + H2O
?
-
preferred peptide substrate
-
-
?
acetyl-YEID-4-nitroanilide + H2O
acetyl-YEID + 4-nitroaniline
-
-
-
-
?
acetyl-YEVD-4-nitroanilide + H2O
acetyl-YEVD + 4-nitroaniline
-
-
-
-
?
acetyl-YQVD-4-nitroanilide + H2O
acetyl-YQVD + 4-nitroaniline
-
-
-
-
?
acid sphingomyelinase + H2O
?
actin-related protein 2/3 complex subunit 3 + H2O
?
-
-
-
-
?
caspase-7 biosensor vDEVDc + H2O
?
claspin + H2O
?
-
cleaved by caspase-7 during the initiation of apoptosis, cleavage at a single aspartate residue into a large N-terminal fragment and a smaller C-terminal fragment that contain different functional domains
-
-
?
DEVD-4-nitroanilide + H2O
DEVD + 4-nitroaniline
-
-
-
?
DEVD-7-amido-4-methylcoumarin + H2O
DEVD + 7-amino-4-methylcoumarin
-
-
-
?
DEVD-7-amido-4-trifluoromethylcoumarin + H2O
DEVD + 7-amino-4-methylcoumarin
-
-
-
-
?
epidermal growth factor receptor + H2O
?
far upstream element binding protein 1 + H2O
?
-
-
-
-
?
FK506-binding protein 4 + H2O
?
-
-
-
-
?
fructose-bisphosphate aldolase A + H2O
?
-
-
-
-
?
gamma-actin + H2O
?
-
-
-
-
?
human telomerase + H2O
?
-
caspase-7 cleaves human telomerase, hTERT, at residues E286 and D628, generation of three major proteolytic fragments, cleavage site determination using caspase-7 resistant substrate mutants D129A, D637A, and D129A/D637A, overview
-
-
?
inhibitor of caspase-actived DNase + H2O
?
-
human caspase-7 is less efficient than caspase-3 at cleaving
-
-
?
Kaposi sarcoma-associated herpesvirus ORF57 + H2O
?
lamin B2 + H2O
?
-
-
-
-
?
mammalian sterile 20-like kinase 1 + H2O
?
N-acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin + H2O
N-acetyl-Asp-Glu-Val-Asp + 7-amino-4-methylcoumarin
-
-
-
-
?
N-acetyl-Asp-Glu-Val-Asp-p-nitroanilide + H2O
N-acetyl-Asp-Glu-Val-Asp + p-nitroaniline
-
-
-
-
?
N-acetyl-DEVD-7-amido-4-fluoromethylcoumarin + H2O
N-acetyl-DEVD + 7-amino-4-fluoromethylcoumarin
-
-
-
?
N-acetyl-DEVD-7-amido-4-methylcoumarin + H2O
N-acetyl-DEVD + 7-amino-4-methylcoumarin
-
-
-
-
?
N-acetyl-DEVD-7-amido-4-trifluoromethylcoumarin + H2O
acetyl-DEVD + 7-amino-4-trifluoromethylcoumarin
-
-
-
?
N-acetyl-PEVD-7-amido-4-trifluoromethylcoumarin + H2O
acetyl-PEVD + 7-amino-4-trifluoromethylcoumarin
-
-
-
?
nucleoside diphosphate kinase B + H2O
?
-
-
-
-
?
pLyn-yellow-fluorescent protein-DEVD-DEVD-C fluorescent protein + H2O
pLyn-yellow-fluorescent protein-DEVD + DEVD-cyan fluorescent protein
-
-
-
-
?
poly(ADP ribose) polymerase 1 + H2O
?
better substrate for caspase-7 than caspase-3, PARP-1 is cleaved at the canonical caspase-3/7 site DEVD*G
-
-
?
poly(ADP-ribose) polymerase + H2O
?
poly(ADP-ribose)polymerase + H2O
?
-
-
-
-
?
poly-ADPribose polymerase 1 + H2O
poly-ADPribose polymerase 1 peptide fragments
proteasome activator complex subunit 1 + H2O
?
-
SwissProt: Q06323
-
-
?
proteasome subunit alpha type-1 + H2O
?
-
SwissProt: P25786
-
-
?
proteasome subunit alpha type-2 + H2O
?
proteasome subunit alpha type-3 + H2O
?
-
SwissProt: P25788
-
-
?
proteasome subunit alpha type-6 + H2O
?
-
SwissProt: P60900
-
-
?
septin 5 + H2O
?
-
i.e. peanut-like protein 1
-
-
?
serine/threonine-protein kinase PAK2 + H2O
?
-
-
-
-
?
TAR DNA binding protein 43 + H2O
?
-
-
-
-
?
thioredoxin peroxidase 1 + H2O
?
-
-
-
-
?
tumor necrosis factor receptor-I + H2O
?
-
mutation E260Q of tumor necrosis factor receptor-I is sufficient to prevent cleavage
-
-
?
valosin-containing protein + H2O
?
VDVAD-7-amido-4-methylcoumarin + H2O
VDVAD + 7-amino-4-methylcoumarin
-
-
-
-
?
vimentin + H2O
?
-
-
-
-
?
viral nucleocapsid protein of transmissible gastroenteritis coronovirus + H2O
?
additional information
?
-
Ac-DEVD-7-amido-4-methylcoumarin + H2O
Ac-DEVD + 7-amino-4-methylcoumarin
-
-
-
-
?
Ac-DEVD-7-amido-4-methylcoumarin + H2O
Ac-DEVD + 7-amino-4-methylcoumarin
-
-
-
?
acid sphingomyelinase + H2O
?
-
caspase-7 activates acid sphingomyelinase induced by TNF, overview. Generation of the active 57 kDa fragment of endogenous A-SMase in wild-type HeLa cells. Direct association of caspase-7 and A-SMase within TNF receptosomes
-
-
?
acid sphingomyelinase + H2O
?
-
A-SMase, caspase-7 activates acid sphingomyelinase induced by TNF, overview
-
-
?
acid sphingomyelinase + H2O
?
-
acid sphingomyelinase, i.e. A-SMase, free or as fusion protein A-SMase-EGFP, a glycosylated protein, caspase-7 activates A-SMase induced by TNF, overview
-
-
?
ataxin-7 + H2O
?
-
ataxin-7 is cleaved by caspase-7, cleavage sites to Asp residues at positions 266 and 344 of the ataxin-7 protein. Proteolytic processing of ataxin-7 by caspase-7 may contribute to SCA7 disease pathogenesis
-
-
?
ataxin-7 + H2O
?
-
ataxin-7 is cleaved by caspase-7, cleavage sites to Asp residues at positions 266 and 344 of the ataxin-7 protein
-
-
?
caspase-7 biosensor vDEVDc + H2O
?
-
wild-type caspase-7 binds to caspase-7 biosensor vDEVDc, but does not cleave it, while an mutant isozymes of caspase-7 with the 24 or 56 N-terminal residues truncated, i.e. 24casp7 and 57casp7, respectively, cleave vDEVDc at the recognition sequence
-
-
?
caspase-7 biosensor vDEVDc + H2O
?
-
wild-type caspase-7 binds to caspase-7 biosensor vDEVDc, but does not cleave it, while an mutant isozymes of caspase-7 with the 24 or 56 N-terminal residues truncated, i.e. 24casp7 and 57casp7, respectively, cleave vDEVDc at the recognition sequence. Computational modeling of the vDEVDc biosensor, overview
-
-
?
epidermal growth factor receptor + H2O
?
-
-
-
-
?
epidermal growth factor receptor + H2O
?
-
cleavage during apoptosis
-
-
?
Kaposi sarcoma-associated herpesvirus ORF57 + H2O
?
-
a viral early protein essential for KSHV multiplication. Cleavage of wild-type or mutant D33A ORF57 by valproate-induced BCBL-1 cell extracts containing active caspases
-
-
?
Kaposi sarcoma-associated herpesvirus ORF57 + H2O
?
-
a viral early protein essential for KSHV multiplication, caspase-7 cleavage site is 30DETD33
-
-
?
kinectin + H2O
?
-
proteolytic cleavage of the 160000 Da enzyme form to a 120000 Da fragment
-
-
?
kinectin + H2O
?
-
kinectin is cleaved by caspase 7 during apoptosis induced by different stimuli. Kinectin functions as a membrane anchor for kinesin and may be relevant to the disruption of vesicle trafficking during apoptosis
-
-
?
mammalian sterile 20-like kinase 1 + H2O
?
-
i.e. Mst1. Caspase 7 preferentially activates c-Jun NH2-terminal kinase and p38 preferentially through 40000 Da cleaved forms of Mst1. The 40000 Da form of Mst1 selectively phosphorylates c-Jun NH2-terminal kinase and p38
-
-
?
mammalian sterile 20-like kinase 1 + H2O
?
-
i.e. Mst1
-
-
?
p23 + H2O
?
better substrate for caspase-7 than caspase-3. p23 is cleaved at site PEVD*G
-
-
?
p23 + H2O
?
i.e. Hsp90 cochaperone p23. Residues 36-45 of caspase-7 participate in p23 recognition. The caspase-7 N-terminal domain binds close to the cleavage site in the C-terminal tail of p23, and cleavage occurs at residues PEVD142-G bearing a P4 Pro residue
-
-
?
PARP + H2O
?
-
-
-
-
?
PARP + H2O
?
-
cleaved by caspase-7 during the initiation of apoptosis, cleavage at a single aspartate residue into a large N-terminal fragment and a smaller C-terminal fragment that contains different functional domains
-
-
?
poly(ADP-ribose) polymerase + H2O
?
-
-
-
-
?
poly(ADP-ribose) polymerase + H2O
?
-
-
-
?
poly(ADP-ribose) polymerase + H2O
?
-
whereas caspase-7 can cleave poly(ADP-ribose) polymerase in vivo, a collaborating caspase facilitates access to poly(ADP-ribose) polymerase, possibly by enhancing nucear entry
-
-
?
poly(ADP-ribose) polymerase + H2O
?
-
whereas caspase-7 can cleave poly(ADP-ribose) polymerase in vivo, a collaborating caspase facilitates access to poly(ADP-ribose) polymerase, possibly by enhancing nuclear entry
-
-
?
poly(ADP-ribose) polymerase + H2O
?
the cleavage of poly(ADP-ribose) polymerase observed during apoptosis cannot solely be attributed to CPP32 but can also be an activity of Mch2alpha
-
-
?
poly-ADPribose polymerase 1 + H2O
poly-ADPribose polymerase 1 peptide fragments
-
-
i.e. c-PARP, frgaments of 24 and 89 kDa
-
?
poly-ADPribose polymerase 1 + H2O
poly-ADPribose polymerase 1 peptide fragments
-
i.e. PARP-1
i.e. c-PARP, frgaments of 24 and 89 kDa
-
?
proteasome subunit alpha type-2 + H2O
?
-
-
-
-
?
proteasome subunit alpha type-2 + H2O
?
-
SwissProt: P25787
-
-
?
valosin-containing protein + H2O
?
-
cleavage by caspase-7 during apoptosis
-
-
?
valosin-containing protein + H2O
?
-
i.e. VCP or transitional endoplasmic reticulum ATPase, recombinant His-tagged substrate expressed in MCF-7 cells, cleavage at both DELD307 and DELD580, no activity with substrate mutant D307A/D580A
-
-
?
viral nucleocapsid protein of transmissible gastroenteritis coronovirus + H2O
?
-
cleavage site VVPD359-/-
-
-
?
viral nucleocapsid protein of transmissible gastroenteritis coronovirus + H2O
?
-
cleavage site VVPD359-/-. Destruction of viral protein by the host cell death machinery
-
-
?
additional information
?
-
-
the preferred cleavage sequence is DEVD-/-
-
-
?
additional information
?
-
-
the preferred cleavage sequence is DEVD-/-
-
-
?
additional information
?
-
no cleavage of YVAD-7-amido-4-methylcoumarin
-
-
?
additional information
?
-
no cleavage of interleukin 1beta precursor
-
-
?
additional information
?
-
-
caspase-7 is the most downstream caspase, overexpression does not lead to the activation of other caspases
-
-
?
additional information
?
-
-
the enzyme is activated during Fas- and tumor necrosis factor-induced apoptosis
-
-
?
additional information
?
-
the enzyme is activated during Fas- and tumor necrosis factor-induced apoptosis
-
-
?
additional information
?
-
-
caspase-7 is an executioner protease in cellular apoptosis
-
-
?
additional information
?
-
-
caspase-7 is an important executioner caspase capable of conducting most of apoptotic program in cells
-
-
?
additional information
?
-
-
caspase-7 is involved in apoptosis and glioblastoma, regulation, overview
-
-
?
additional information
?
-
-
caspase-7 is involved in apoptosis in cancer cells
-
-
?
additional information
?
-
-
caspase-7 is involved in apoptosis. Follistatin-like 1, FSTL1, induces apoptosis in cancer cells and leads to activation of caspase-7 when transfected to ovarian or endometrial cancer or healthy cells, regulation, overview
-
-
?
additional information
?
-
-
functions of caspase-7 during apoptosis, overview
-
-
?
additional information
?
-
-
hypertonicity-induced cation channels, HICC, inhibition by flufenamate and silencing of alpha-ENaC increases the rate of apoptosis in HepG2 cells via activation of caspase-7 or caspase-3
-
-
?
additional information
?
-
-
inhibition of executioner caspase enzymatic activity by TLCK and TPCK in dying HL-60 cells is important in prevention of cell death
-
-
?
additional information
?
-
-
members of the caspase family of cysteine proteases play central roles in coordinating the stereotypical events that occur during apoptosis, the major executioner caspases are caspase-3 and caspase-7, which show overlapping substrate specificities, overview
-
-
?
additional information
?
-
-
possible involvement of caspase-7 in cell cycle progression at mitosis, caspases including caspase-3, caspase-7, caspase-8 and caspase-9, are activated during mitosis and are potentially involved in the regulation at M phase. Chemically synthesized caspase inhibitors delay mitotic progression and induce accumulation of mitotic cells, which exhibits abnormal chromatin condensation and incomplete chromosome segregation
-
-
?
additional information
?
-
-
tyrosine kinase TrkA overexpression induces substantial cell death even in the absence of NGF, by stimulating ERK phosphorylation and caspase-7 activation leading to PARP cleavage, mechanism, overview
-
-
?
additional information
?
-
-
caspase-7, like caspase-3, shows substrate specificity with special preference for the DEVD motif, peptide products, overview
-
-
?
additional information
?
-
-
no activity of mutant 57casp7 isozyme with control biosensor v4Gc
-
-
?
additional information
?
-
the enzyme does not cleave ICAD
-
-
?
additional information
?
-
no activity with N-acetyl-PEVD-7-amido-4-fluoromethylcoumarin
-
-
?
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Adenocarcinoma
Potentially Functional Polymorphisms in the CASP7 Gene Contribute to Gastric Adenocarcinoma Susceptibility in an Eastern Chinese Population.
Adenocarcinoma
Protein and phosphoprotein levels in glioma and adenocarcinoma cell lines grown in normoxia and hypoxia in monolayer and three-dimensional cultures.
Adenocarcinoma
Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells.
Adenocarcinoma
Variant TP53BP1 rs560191 G>C is associated with risk of gastric cardia adenocarcinoma in a Chinese Han population.
Adenocarcinoma of Lung
Stable silencing of ROR1 regulates cell cycle, apoptosis, and autophagy in a lung adenocarcinoma cell line.
Alzheimer Disease
A loss of function variant in CASP7 protects against Alzheimer's disease in homozygous APOE ?4 allele carriers.
Alzheimer Disease
A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease.
Alzheimer Disease
Genome-wide haplotype association study identify TNFRSF1A, CASP7, LRP1B, CDH1 and TG genes associated with Alzheimer's disease in Caribbean Hispanic individuals.
Arthritis
Chondroitin-4-sulphate inhibits NF-kB translocation and caspase activation in collagen-induced arthritis in mice.
Arthritis, Rheumatoid
Caspase 7 influences susceptibility to rheumatoid arthritis.
Arthritis, Rheumatoid
Genetic and expression analysis of CASP7 gene in a European Caucasian population with rheumatoid arthritis.
Ataxia
Case control analysis of repeat expansion size in ataxia.
Ataxia
Late-onset SCA2: 33 CAG repeats are sufficient to cause disease.
Ataxia
Mutation at the SCA17 locus is not a common cause of parkinsonism.
Ataxia
Overwhelming genetic heterogeneity and exhausting molecular diagnostic process in chronic and progressive ataxias: facing it up with an algorithm, a gene, a panel at a time.
Ataxia
Spastic paraplegia, ataxia, mental retardation (SPAR): a novel genetic disorder.
Ataxia
Synapses in the hereditary ataxias.
Ataxia Telangiectasia
Epigenetic inactivation of BCL6B, a novel functional tumour suppressor for gastric cancer, is associated with poor survival of gastric cancer.
Ataxia Telangiectasia
JS-K, a nitric oxide prodrug, induces DNA damage and apoptosis in HBV-positive hepatocellular carcinoma HepG2.2.15 cell.
Brain Injuries
Caspase 7: increased expression and activation after traumatic brain injury in rats.
Brain Injuries
Necroptotic-Apoptotic Regulation in an Endothelin-1 Model of Cerebral Ischemia.
Brain Injuries, Traumatic
Caspase 7: increased expression and activation after traumatic brain injury in rats.
Brain Injuries, Traumatic
Proteolysis consistent with activation of caspase-7 after severe traumatic brain injury in humans.
Brain Ischemia
[Mechanism of Chuanxiong Rhizoma-Paeoniae Radix Rubra drug pair on intervention of cerebral ischemia based on network pharmacology-molecular docking].
Breast Neoplasms
2-aryl benzimidazole conjugate induced apoptosis in human breast cancer MCF-7 cells through caspase independent pathway.
Breast Neoplasms
Anti-miR-203 Upregulates SOCS3 Expression in Breast Cancer Cells and Enhances Cisplatin Chemosensitivity.
Breast Neoplasms
Anticancer Potential of Silibinin Loaded Polymeric Nanoparticles against Breast Cancer Cells: Insight into the Apoptotic Genes Targets.
Breast Neoplasms
Apoptosis induction in human breast cancer (MCF-7) cells by a novel venom L-amino acid oxidase (Rusvinoxidase) is independent of its enzymatic activity and is accompanied by caspase-7 activation and reactive oxygen species production.
Breast Neoplasms
Biochemical pathways mediated by KLK6 protease in breast cancer.
Breast Neoplasms
Biphasic dose-dependent effect of lithium chloride on survival of human hormone-dependent breast cancer cells (mcf-7).
Breast Neoplasms
Blockade of GRP78 sensitizes breast cancer cells to microtubules-interfering agents that induce the unfolded protein response.
Breast Neoplasms
Efficacy of sulforaphane is mediated by p38 MAP kinase and caspase-7 activations in ER-positive and COX-2-expressed human breast cancer cells.
Breast Neoplasms
Gamma-tocotrienol induced apoptosis is associated with unfolded protein response in human breast cancer cells.
Breast Neoplasms
ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis.
Breast Neoplasms
Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047.
Breast Neoplasms
Limonoids and their anti-proliferative and anti-aromatase properties in human breast cancer cells.
Breast Neoplasms
Low cleaved caspase-7 levels indicate unfavourable outcome across all breast cancers.
Breast Neoplasms
New Alkoxy Flavone Derivatives Targeting Caspases: Synthesis and Antitumor Activity Evaluation.
Breast Neoplasms
Optical nanobiosensor for monitoring an apoptotic signaling process in a single living cell following photodynamic therapy.
Breast Neoplasms
Overexpression of caspase 7 is ER? dependent to affect proliferation and cell growth in breast cancer cells by targeting p21(Cip).
Breast Neoplasms
Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines.
Breast Neoplasms
PPAR?-inactive ?2-troglitazone independently triggers ER stress and apoptosis in breast cancer cells.
Breast Neoplasms
Prioritizing disease biomarkers using functional module based network analysis: A multilayer consensus driven scheme.
Breast Neoplasms
Traumatic acid toxicity mechanisms in human breast cancer MCF-7?cells.
Breast Neoplasms
Up-regulation of gamma-synuclein contributes to cancer cell survival under endoplasmic reticulum stress.
Breast Neoplasms
YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells.
Bulbo-Spinal Atrophy, X-Linked
Cerebellar allografts survive and transiently alleviate ataxia in a transgenic model of spinocerebellar ataxia type-1.
Bulbo-Spinal Atrophy, X-Linked
Transglutaminase-dependent formation of protein aggregates as possible biochemical mechanism for polyglutamine diseases.
Carcinogenesis
Caspase expression in oral squamous cell carcinoma.
Carcinogenesis
Genetic ablation of caspase-7 promotes solar-simulated light-induced mouse skin carcinogenesis: the involvement of keratin-17.
Carcinogenesis
miR-224 Is Significantly Upregulated and Targets Caspase-3 and Caspase-7 During Colorectal Carcinogenesis.
Carcinogenesis
Prediction and Analysis of Skin Cancer Progression using Genomics Profiles of Patients.
Carcinogenesis
[Expression of survivin and caspase-3 in non-Hodgkin's lymphoma and their clinical significance]
Carcinogenesis
[Expressions of survivin and caspase-3 in human non-small cell lung cancer and their relationship with cell apoptosis.]
Carcinoma
A compound isolated from Schisandra chinensis induces apoptosis.
Carcinoma
Assessment of apoptosis by immunohistochemistry to active caspase-3, active caspase-7, or cleaved PARP in monolayer cells and spheroid and subcutaneous xenografts of human carcinoma.
Carcinoma
Caspase 7 downregulation as an immunohistochemical marker of colonic carcinoma.
Carcinoma
Combination of Pitavastatin and melatonin shows partial antineoplastic effects in a rat breast carcinoma model.
Carcinoma
Cytochrome c is involved in Fas-mediated apoptosis of prostatic carcinoma cell lines.
Carcinoma
Expression and Prognostic Significance of Livin, Caspase-3, and Ki-67 in the Progression of Human Ampullary Carcinoma.
Carcinoma
Fas-mediated apoptosis in human prostatic carcinoma cell lines occurs via activation of caspase-8 and caspase-7.
Carcinoma
Genetic ablation of caspase-7 promotes solar-simulated light-induced mouse skin carcinogenesis: the involvement of keratin-17.
Carcinoma
Inactivating mutations of CASPASE-7 gene in human cancers.
Carcinoma
Inhibition of human pancreatic cell line MIA PaCa2 proliferation by HA-But, a hyaluronic butyric ester: a preliminary report.
Carcinoma
Investigating cytokinesis failure as a strategy in cancer therapy.
Carcinoma
Loss of caspase 7 expression is associated with poor prognosis in renal cell carcinoma clear cell subtype.
Carcinoma
Melatonin potentiates the anti-tumour effect of pravastatin in rat mammary gland carcinoma model.
Carcinoma
Role of IRF-1 and caspase-7 in IFN-gamma enhancement of Fas-mediated apoptosis in ACHN renal cell carcinoma cells.
Carcinoma, Basal Cell
Genetic ablation of caspase-7 promotes solar-simulated light-induced mouse skin carcinogenesis: the involvement of keratin-17.
Carcinoma, Ductal
Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines.
Carcinoma, Hepatocellular
Functional characterization of hepatoma-specific stem cell antigen-2.
Carcinoma, Hepatocellular
Identification of components of grape powder with anti-apoptotic effects.
Carcinoma, Hepatocellular
The anti-cancer flavonoid chrysin induces the unfolded protein response in hepatoma cells.
Carcinoma, Non-Small-Cell Lung
Association of CASP7 Polymorphisms and Survival of Non-Small-Cell Lung Cancer Patients with Platinum-Based Chemotherapy Treatment.
Carcinoma, Non-Small-Cell Lung
Prognostic assessment of apoptotic gene polymorphisms in non-small cell lung cancer in Chinese.
Carcinoma, Renal Cell
Loss of caspase 7 expression is associated with poor prognosis in renal cell carcinoma clear cell subtype.
Carcinoma, Renal Cell
Role of IRF-1 and caspase-7 in IFN-gamma enhancement of Fas-mediated apoptosis in ACHN renal cell carcinoma cells.
Cardiomyopathies
A novel compound DT-010 protects against doxorubicin-induced cardiotoxicity in zebrafish and H9c2 cells by inhibiting reactive oxygen species-mediated apoptotic and autophagic pathways.
Cardiomyopathies
Apoptotic versus autophagic cell death in heart failure.
caspase-7 deficiency
Caspase 7 downregulation as an immunohistochemical marker of colonic carcinoma.
caspase-7 deficiency
Caspase-7 deficiency in Chinese hamster ovary cells reduces cell proliferation and viability.
caspase-7 deficiency
Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival.
caspase-7 deficiency
NLRP3 Inflammasome Deficiency Protects Against Microbial Sepsis via Increased Lipoxin B4 Synthesis.
caspase-7 deficiency
Non-apoptotic role for caspase-7 in hair follicles and the surrounding tissue.
Chondrosarcoma
MLN4924, a Protein Neddylation Inhibitor, Suppresses the Growth of Human Chondrosarcoma through Inhibiting Cell Proliferation and Inducing Endoplasmic Reticulum Stress-Related Apoptosis.
Coinfection
bta-miR-29b attenuates apoptosis by directly targeting caspase-7 and NAIF1 and suppresses bovine viral diarrhea virus replication in MDBK cells.
Colonic Neoplasms
2'-Hydroxycinnamaldehyde induces apoptosis through HSF1-mediated BAG3 expression.
Colonic Neoplasms
Antioxidants decrease the apoptotic effect of 5-Fu in colon cancer by regulating Src-dependent caspase-7 phosphorylation.
Colonic Neoplasms
Caspase 7 downregulation as an immunohistochemical marker of colonic carcinoma.
Colonic Neoplasms
Evidence of cell damage induced by major components of a diet-compatible mixture of oxysterols in human colon cancer CaCo-2 cell line.
Colonic Neoplasms
Immune-Related Prognostic Model in Colon Cancer: A Gene Expression-Based Study.
Colonic Neoplasms
Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth.
Colonic Neoplasms
Regulation of caspase expression and apoptosis by adenomatous polyposis coli.
Colonic Neoplasms
Short-chain fatty acids induced autophagy serves as an adaptive strategy for retarding mitochondria-mediated apoptotic cell death.
Colonic Neoplasms
Tissue factor-factor VIIa regulates interleukin-8, tissue factor and caspase-7 expression in SW620 cells through protease-activated receptor-2 activation.
Colorectal Neoplasms
miR-224 Is Significantly Upregulated and Targets Caspase-3 and Caspase-7 During Colorectal Carcinogenesis.
Colorectal Neoplasms
RIPK1 and CASP7 polymorphism as prognostic markers for survival in patients with colorectal cancer after complete resection.
Colorectal Neoplasms
Targeting SREBP1 chemosensitizes colorectal cancer cells to gemcitabine by caspase-7 upregulation.
Congenital Abnormalities
Calcium Alleviates Fluoride-Induced Bone Damage by Inhibiting Endoplasmic Reticulum Stress and Mitochondrial Dysfunction.
Dementia
Mutation at the SCA17 locus is not a common cause of parkinsonism.
Diabetes Mellitus, Type 1
Caspase 7 is a positional candidate gene for IDDM 17 in a Bedouin Arab family.
Dystonia
Mutation at the SCA17 locus is not a common cause of parkinsonism.
Endometrial Hyperplasia
Autophagy in the physiological endometrium and cancer.
Endometrial Neoplasms
Autophagy in the physiological endometrium and cancer.
Endometrial Neoplasms
Polymorphisms and haplotypes in the caspase-3, caspase-7, and caspase-8 genes and risk for endometrial cancer: a population-based, case-control study in a Chinese population.
Endotoxemia
Caspase-7: A protease involved in apoptosis and inflammation.
Fibrosarcoma
Effect of TERT on the growth of fibrosarcoma via caspase-3, survivin and PKB.
Fibrosarcoma
Kringle 5 of human plasminogen induces apoptosis of endothelial and tumor cells through surface-expressed glucose-regulated protein 78.
Glaucoma
Caspase-7: a critical mediator of optic nerve injury-induced retinal ganglion cell death.
Glioblastoma
Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma.
Glioblastoma
The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.
Glioma
Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma.
Glioma
GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis.
Glioma
Pre-treatment or Post-treatment of Human Glioma Cells With BIX01294, the Inhibitor of Histone Methyltransferase G9a, Sensitizes Cells to Temozolomide.
Glioma
Protein and phosphoprotein levels in glioma and adenocarcinoma cell lines grown in normoxia and hypoxia in monolayer and three-dimensional cultures.
Glioma
Tumor therapy mediated by lentiviral expression of shBcl-2 and S-TRAIL.
Glioma
Two different mechanisms of apoptosis resistance observed in interferon-beta induced apoptosis of human glioma cells.
Hearing Loss, Noise-Induced
Role of CASP7 polymorphisms in noise-induced hearing loss risk in Han Chinese population.
Hepatitis B
Hepatitis B vaccine induces apoptotic death in Hepa1-6 cells.
Huntington Disease
Cerebellar allografts survive and transiently alleviate ataxia in a transgenic model of spinocerebellar ataxia type-1.
Huntington Disease
DNA damage induced by polyglutamine-expanded proteins.
Huntington Disease
Increased caspase-2, calpain activations and decreased mitochondrial complex II activity in cells expressing exogenous huntingtin exon 1 containing CAG repeat in the pathogenic range.
Huntington Disease
Transglutaminase-dependent formation of protein aggregates as possible biochemical mechanism for polyglutamine diseases.
Infections
Caspase-3-like proteases are activated by infection but are not required for replication of vesicular stomatitis virus.
Infections
Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection.
Infections
Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression.
Infections
Caspase-Mediated Cleavage of Human Cortactin during Influenza A Virus Infection Occurs in Its Actin-Binding Domains and Is Associated with Released Virus Titres.
Infections
Enterovirus 71 induces apoptosis of SH?SY5Y human neuroblastoma cells through stimulation of endogenous microRNA let-7b expression.
Infections
Exoenzyme Y induces extracellular active caspase-7 accumulation independent from apoptosis: modulation of transmissible cytotoxicity.
Infections
HCV Induces Telomerase Reverse Transcriptase, Increases Its Catalytic Activity, and Promotes Caspase Degradation in Infected Human Hepatocytes.
Infections
Membrane damage during Listeria monocytogenes infection triggers a caspase-7 dependent cytoprotective response.
Infections
Selenium Plays a Protective Role in Staphylococcus aureus-Induced Endometritis in the Uterine Tissue of Rats.
Infections
The Acinetobacter trimeric autotransporter adhesin Ata controls key virulence traits of Acinetobacter baumannii.
Infections
The JAK/STAT3 signaling pathway mediates inhibition of host cell apoptosis by Chlamydia psittaci infection.
Inflammatory Bowel Diseases
miR-224 Is Significantly Upregulated and Targets Caspase-3 and Caspase-7 During Colorectal Carcinogenesis.
Influenza, Human
Influenza virus induces apoptosis via BAD-mediated mitochondrial dysregulation.
Influenza, Human
Interaction of influenza A virus M1 matrix protein with caspases.
Ischemic Stroke
Association of genetic polymorphisms in CASP7 with risk of ischaemic stroke.
Legionnaires' Disease
Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection.
Leukemia
Anticancer activity of a synthetic peptide derived from harmoniasin, an antibacterial peptide from the ladybug Harmonia axyridis.
Leukemia
Association between CASP7 and CASP14 genetic polymorphisms and the risk of childhood leukemia.
Leukemia
Bifidobacterium breve - HT-29 cell line interaction: modulation of TNF-? induced gene expression.
Leukoplakia
Sequence and expression variations in 23 genes involved in mitochondrial and non-mitochondrial apoptotic pathways and risk of oral leukoplakia and cancer.
Lung Neoplasms
A literature-based systematic HuGE review and meta-analysis show that CASP gene family polymorphisms are associated with risk of lung cancer.
Lung Neoplasms
Albanol B from Mulberries Exerts Anti-Cancer Effect through Mitochondria ROS Production in Lung Cancer Cells and Suppresses In Vivo Tumor Growth.
Lung Neoplasms
ASH1 gene is a specific therapeutic target for lung cancers with neuroendocrine features.
Lung Neoplasms
Association of CASP7 Polymorphisms and Survival of Non-Small-Cell Lung Cancer Patients with Platinum-Based Chemotherapy Treatment.
Lung Neoplasms
MicroRNA-224 is implicated in lung cancer pathogenesis through targeting caspase-3 and caspase-7.
Lung Neoplasms
Polymorphisms in the caspase genes and the risk of lung cancer.
Lung Neoplasms
Polymorphisms in the Caspase7 gene and the risk of lung cancer.
Lung Neoplasms
Prognostic assessment of apoptotic gene polymorphisms in non-small cell lung cancer in Chinese.
Lymphoma
Absence of CASP7 and CASP8 mutation in gastrointestinal lymphomas.
Lymphoma
Anti-CD20 antibody (IDEC-C2B8, rituximab) enhances efficacy of cytotoxic drugs on neoplastic lymphocytes in vitro: role of cytokines, complement, and caspases.
Lymphoma
Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression.
Lymphoma
Endoplasmic Reticulum Stress and Neurodegeneration in Experimental Cerebral Malaria.
Lymphoma
Implication of calpain in caspase activation during B cell clonal deletion.
Lymphoma
Mitochondria-dependent caspase-9 activation is necessary for antigen receptor-mediated effector caspase activation and apoptosis in WEHI 231 lymphoma cells.
Lymphoma
Synergistic anticancer effects of bufalin and sorafenib by regulating apoptosis associated proteins.
Lymphoma, B-Cell
Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression.
Lymphoma, B-Cell
Deficiency of dietary pyridoxine disturbed the intestinal physical barrier function of young grass carp (Ctenopharyngodon idella).
Lymphoma, B-Cell
Endoplasmic Reticulum Stress and Neurodegeneration in Experimental Cerebral Malaria.
Lymphoma, B-Cell
Implication of calpain in caspase activation during B cell clonal deletion.
Lymphoma, B-Cell
MicroRNA-181a suppresses norethisterone-promoted tumorigenesis of breast epithelial MCF10A cells through the PGRMC1/EGFR-PI3K/Akt/mTOR signaling pathway.
Lymphoma, B-Cell
Naringin inhibits ovarian tumor growth by promoting apoptosis: An in vivo study.
Lymphoma, B-Cell
Suppression of tumor cell proliferation and migration by human umbilical cord mesenchymal stem cells: A possible role for apoptosis and Wnt signaling.
Lymphoma, B-Cell
The Inhibitory Effect of Cordycepin on the Proliferation of MCF-7 Breast Cancer Cells, and its Mechanism: An Investigation Using Network Pharmacology-Based Analysis.
Machado-Joseph Disease
Transglutaminase-dependent formation of protein aggregates as possible biochemical mechanism for polyglutamine diseases.
Medulloblastoma
Cleaved caspase-3, caspase-7 and poly (ADP-ribose) polymerase are complementarily but differentially expressed in human medulloblastomas.
Medulloblastoma
The alkylphospholipid perifosine induces apoptosis and p21-mediated cell cycle arrest in medulloblastoma.
Melanoma
Cisplatin-induced apoptosis in melanoma cells: role of caspase-3 and caspase-7 in Apaf-1 proteolytic cleavage and in execution of the degradative phases.
Melanoma
Livin/melanoma inhibitor of apoptosis protein as a potential therapeutic target for the treatment of malignancy.
Melanoma
Prediction and Analysis of Skin Cancer Progression using Genomics Profiles of Patients.
Mouth Neoplasms
MicroRNA-205 suppresses the oral carcinoma oncogenic activity via down-regulation of Axin-2 in KB human oral cancer cell.
Mouth Neoplasms
Sequence and expression variations in 23 genes involved in mitochondrial and non-mitochondrial apoptotic pathways and risk of oral leukoplakia and cancer.
Multiple System Atrophy
Structural and immunocytochemical features of olivopontocerebellar atrophy caused by the spinocerebellar ataxia type 1 (SCA-1) mutation define a unique phenotype.
Myoclonic Epilepsies, Progressive
Cerebellar allografts survive and transiently alleviate ataxia in a transgenic model of spinocerebellar ataxia type-1.
Neoplasm Metastasis
Biochemical pathways mediated by KLK6 protease in breast cancer.
Neoplasm Metastasis
Gene signature based on degradome-related genes can predict distal metastasis in cervical cancer patients.
Neoplasms
A Combined ULBP2 and SEMA5A Expression Signature as a Prognostic and Predictive Biomarker for Colon Cancer.
Neoplasms
A novel diterpene suppresses CWR22Rv1 tumor growth in vivo through antiproliferation and proapoptosis.
Neoplasms
A single amino acid substitution confers B-cell clonogenic activity to the HIV-1 matrix protein p17.
Neoplasms
Active caspases and cleaved cytokeratins are sequestered into cytoplasmic inclusions in TRAIL-induced apoptosis.
Neoplasms
Anti-neoplastic activity of Amblyomma sculptum, Amblyomma parvum and Rhipicephalus sanguineus tick saliva on breast tumor cell lines.
Neoplasms
Antineoplastic effects of Chlorella pyrenoidosa in the breast cancer model.
Neoplasms
Antitumoral Effects of Melissa officinalis on Breast Cancer in Vitro and in Vivo.
Neoplasms
Autophagy in the physiological endometrium and cancer.
Neoplasms
Black tea polyphenols restrict benzopyrene-induced mouse lung cancer progression through inhibition of Cox-2 and induction of caspase-3 expression.
Neoplasms
Calpain-1 cleaves and activates caspase-7.
Neoplasms
Canavanine augments proapoptotic effects of arginine deprivation in cultured human cancer cells.
Neoplasms
Capsaicin-induced inactivation of sensory neurons promotes a more aggressive gene expression phenotype in breast cancer cells.
Neoplasms
Caspase 7 can cleave tumor necrosis factor receptor-I (p60) at a non-consensus motif, in vitro.
Neoplasms
Caspase 7 downregulation as an immunohistochemical marker of colonic carcinoma.
Neoplasms
Caspase polymorphisms and prognosis of hepatocellular carcinoma.
Neoplasms
Caspase-7: A protease involved in apoptosis and inflammation.
Neoplasms
Chondroitin-4-sulphate reduced oxidative injury in caerulein-induced pancreatitis in mice: the involvement of NF-kappaB translocation and apoptosis activation.
Neoplasms
Cleaved caspase-3, caspase-7 and poly (ADP-ribose) polymerase are complementarily but differentially expressed in human medulloblastomas.
Neoplasms
Compound 21 and Telmisartan combination mitigates type 2 diabetic nephropathy through amelioration of caspase mediated apoptosis.
Neoplasms
Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells.
Neoplasms
Design and Synthesis of New CDK2 Inhibitors Containing Thiazolone and Thiazolthione Scafold with Apoptotic Activity.
Neoplasms
Design, synthesis and biological evaluation of cinnamic acyl shikonin derivatives.
Neoplasms
Development and therapeutic options for the treatment of raloxifene-stimulated breast cancer in athymic mice.
Neoplasms
Discovery of New H2S Releasing Phosphordithioates and 2,3-Dihydro-2-phenyl-2-sulfanylenebenzo[d][1,3,2]oxazaphospholes with Improved Antiproliferative Activity.
Neoplasms
Effects of chlorella on activities of protein tyrosine phosphatases, matrix metalloproteinases, caspases, cytokine release, B and T cell proliferations, and phorbol ester receptor binding.
Neoplasms
Effects of matrine in combination with cisplatin on liver cancer.
Neoplasms
Effects of short-term finasteride on apoptotic factors and androgen receptors in prostate cancer cells.
Neoplasms
Epigenetic inactivation of BCL6B, a novel functional tumour suppressor for gastric cancer, is associated with poor survival of gastric cancer.
Neoplasms
Estrone-salicylaldehyde N-methylated thiosemicarbazone hybrids and their copper complexes: solution structure, stability and anticancer activity in tumour spheroids.
Neoplasms
Expression of caspase-3 and -7 does not correlate with the extent of apoptosis in primary breast carcinomas.
Neoplasms
Failure of activation of caspase-9 induces a higher threshold for apoptosis and cisplatin resistance in testicular cancer.
Neoplasms
Features of the Copy Number Variation of Certain Genes in Tumor Cells in Patients with Serous Ovarian Adenocarcinoma.
Neoplasms
Fish oil administration mediates apoptosis of Walker 256 tumor cells by modulation of p53, Bcl-2, caspase-7 and caspase-3 protein expression.
Neoplasms
Functional characterization of hepatoma-specific stem cell antigen-2.
Neoplasms
Gedunin Inactivates the Co-chaperone p23 Protein Causing Cancer Cell Death by Apoptosis.
Neoplasms
Genetic ablation of caspase-7 promotes solar-simulated light-induced mouse skin carcinogenesis: the involvement of keratin-17.
Neoplasms
Germacrone Inhibits Cell Proliferation and Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cells.
Neoplasms
Green tea and quercetin sensitize PC-3 xenograft prostate tumors to docetaxel chemotherapy.
Neoplasms
Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors.
Neoplasms
Heat shock protein 70-2 (HSP70-2) a novel cancer testis antigen that promotes growth of ovarian cancer.
Neoplasms
HuGE systematic review and meta-analysis demonstrate association of CASP-3 and CASP-7 genetic polymorphisms with cancer risk.
Neoplasms
ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis.
Neoplasms
Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening.
Neoplasms
Immunoreactivity to caspase-3, caspase-7, caspase-8, and caspase-9 forms is frequently lost in human prostate tumors.
Neoplasms
Implication of calpain in caspase activation during B cell clonal deletion.
Neoplasms
Improving Topical Non-Melanoma Skin Cancer Treatment: In vitro Efficacy of a Novel Guanosine-Analog Phosphonate.
Neoplasms
Inactivated Sendai Virus Strain Tianjin Induces Apoptosis in Breast Cancer MCF-7 Cells by Promoting Caspase Activation and Fas/FasL Expression.
Neoplasms
Inactivating mutations of CASPASE-7 gene in human cancers.
Neoplasms
Influence of Canine Macrophage-derived Extracellular Vesicles on Apoptosis in Canine Melanoma and Osteosarcoma Cell Lines.
Neoplasms
Inhibitory role of peroxisome proliferator-activated receptor gamma in hepatocarcinogenesis in mice and in vitro.
Neoplasms
Integrative in silico and in vitro transcriptomics analysis revealed new lncRNAs related to intrinsic apoptotic genes in colorectal cancer.
Neoplasms
Investigating cytokinesis failure as a strategy in cancer therapy.
Neoplasms
Ketoconazole Treatment Decreases the Viability of Immortalized Pituitary Cell Lines Associated with an Increased Expression of Apoptosis-Related Genes and Cell Cycle Inhibitors.
Neoplasms
Large-scale expression in Escherichia coli and efficient purification of precursor and active caspase-7 by introduction of thrombin cleavage sites.
Neoplasms
Low cleaved caspase-7 levels indicate unfavourable outcome across all breast cancers.
Neoplasms
MicroRNA-106b-25 cluster expression is associated with early disease recurrence and targets caspase-7 and focal adhesion in human prostate cancer.
Neoplasms
MicroRNA-23a is involved in tumor necrosis factor-? induced apoptosis in mesenchymal stem cells and myocardial infarction.
Neoplasms
MicroRNA-519a-3p mediates apoptosis resistance in breast cancer cells and their escape from recognition by natural killer cells.
Neoplasms
miR-224 Is Significantly Upregulated and Targets Caspase-3 and Caspase-7 During Colorectal Carcinogenesis.
Neoplasms
Modulation of effector caspase cleavage determines response of breast and lung tumor cell lines to chemotherapy.
Neoplasms
Nitrogen Permease Regulator-Like-2 Exhibited Anti-Tumor Effects And Enhanced The Sensitivity Of Colorectal Cancer Cells To Oxaliplatin And 5-Fluorouracil.
Neoplasms
Overexpression of caspase 7 is ER? dependent to affect proliferation and cell growth in breast cancer cells by targeting p21(Cip).
Neoplasms
Plasminogen kringle 5 suppresses gastric cancer via regulating HIF-1? and GRP78.
Neoplasms
Pogostone Induces Autophagy and Apoptosis Involving PI3K/Akt/mTOR Axis in Human Colorectal Carcinoma HCT116 cells.
Neoplasms
Polymorphisms and haplotypes in the caspase-3, caspase-7, and caspase-8 genes and risk for endometrial cancer: a population-based, case-control study in a Chinese population.
Neoplasms
Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis.
Neoplasms
Potential small-molecule activators of caspase-7 identified using yeast-based caspase-3 and -7 screening assays.
Neoplasms
Potentially Functional Polymorphisms in the CASP7 Gene Contribute to Gastric Adenocarcinoma Susceptibility in an Eastern Chinese Population.
Neoplasms
Selenopheno quinolinones and coumarins promote cancer cell apoptosis by ROS depletion and caspase-7 activation.
Neoplasms
Sequence and expression variations in 23 genes involved in mitochondrial and non-mitochondrial apoptotic pathways and risk of oral leukoplakia and cancer.
Neoplasms
Stable silencing of ROR1 regulates cell cycle, apoptosis, and autophagy in a lung adenocarcinoma cell line.
Neoplasms
Suppression of tumor cell proliferation and migration by human umbilical cord mesenchymal stem cells: A possible role for apoptosis and Wnt signaling.
Neoplasms
Synergistic effects of 7-O-geranylquercetin and siRNAs on the treatment of human breast cancer.
Neoplasms
Synthesis of D-ring annulated pyridosteroids from ?-formyl enamides and their biological evaluations.
Neoplasms
Synthesis, Characterization, and In Vivo Anti-Cancer Activity of New Metal Complexes Derived from Isatin-N(4)antipyrinethiosemicarbazone Ligand Against Ehrlich Ascites Carcinoma Cells.
Neoplasms
Targeted apoptotic effects of thymoquinone and tamoxifen on XIAP mediated Akt regulation in breast cancer.
Neoplasms
Targeting the XIAP/caspase-7 complex selectively kills caspase-3-deficient malignancies.
Neoplasms
The Caspase-3/PKC?/Akt/VEGF-A Signaling Pathway Mediates Tumor Repopulation during Radiotherapy.
Neoplasms
The combination effects of Shen-Ling-Bai-Zhu on promoting apoptosis of transplanted H22 hepatocellular carcinoma in mice receiving chemotherapy.
Neoplasms
The novel camptothecin derivative, CPT211, induces cell cycle arrest and apoptosis in models of human breast cancer.
Neoplasms
Therapeutic targeting of Id2 reduces growth of human colorectal carcinoma in the murine liver.
Neoplasms
Transduction motif analysis of gastric cancer based on a human signaling network.
Neoplasms
Trifluridine selectively inhibits cell growth and induces cell apoptosis of triple-negative breast cancer.
Neoplasms
Unshackling caspase-7 for cancer therapy.
Neoplasms
[Expression of survivin and its correlation to angiogenesis in oral squamous cell carcinoma]
Neoplasms
[Investigation of the mechanisms of coagulation factor VIIa-induced colon cancer SW620 cell proliferation and migration]
Neoplasms
[Study on Apoptosis of Oral Squamous Carcinoma Cell line KB and KBv200 induced by Survivin RNAi.]
Neoplasms, Germ Cell and Embryonal
Failure of activation of caspase-9 induces a higher threshold for apoptosis and cisplatin resistance in testicular cancer.
Neuroblastoma
Identification of genes associated with paraquat-induced toxicity in SH-SY5Y cells by PCR array focused on apoptotic pathways.
Neuroblastoma
Synergistic induction of apoptosis in neuroblastoma cells using a combination of cytostatic drugs with interferon-gamma and TRAIL.
Neurodegenerative Diseases
Calpain-1 cleaves and activates caspase-7.
Neurodegenerative Diseases
Caspase-7: a critical mediator of optic nerve injury-induced retinal ganglion cell death.
Neurodegenerative Diseases
Cerebellar allografts survive and transiently alleviate ataxia in a transgenic model of spinocerebellar ataxia type-1.
Non-alcoholic Fatty Liver Disease
Adipose tissue remodelling in obese subjects is a determinant of presence and severity of fatty liver disease.
Olivopontocerebellar Atrophies
The hereditary ataxias.
Osteosarcoma
Interferon-? Sensitises Human Osteosarcoma Cells to Trail-mediated Apoptosis.
Osteosarcoma
Serine/Threonine Kinase 35, a Target Gene of STAT3, Regulates the Proliferation and Apoptosis of Osteosarcoma Cells.
Osteosarcoma
Targeted inhibition of mTORC2 prevents osteosarcoma cell migration and promotes apoptosis.
Ovarian Neoplasms
HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells.
Pancreatitis
Genetic Susceptibility in Acute Pancreatitis: Genotyping of GSTM1, GSTT1, GSTP1, CASP7, CASP8, CASP9, CASP10, LTA, TNFRSF1B, and TP53 Gene Variants.
Parkinson Disease
Analysis of SCA-2 and SCA-3 repeats in Parkinsonism: evidence of SCA-2 expansion in a family with autosomal dominant Parkinson's disease.
Parkinson Disease
Mutation at the SCA17 locus is not a common cause of parkinsonism.
Parkinsonian Disorders
Analysis of SCA-2 and SCA-3 repeats in Parkinsonism: evidence of SCA-2 expansion in a family with autosomal dominant Parkinson's disease.
Parkinsonian Disorders
Mutation at the SCA17 locus is not a common cause of parkinsonism.
Parkinsonian Disorders
SCA-2 presenting as parkinsonism in an Alberta family: clinical, genetic, and PET findings.
Periodontitis
Caspase activation is involved in chronic periodontitis.
Prostatic Neoplasms
Apoptotic activity and mechanism of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic-acid and related synthetic triterpenoids in prostate cancer.
Prostatic Neoplasms
Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP.
Prostatic Neoplasms
Endoplasmic reticulum stress signal mediators are targets of selenium action.
Prostatic Neoplasms
MicroRNA-106b-25 cluster expression is associated with early disease recurrence and targets caspase-7 and focal adhesion in human prostate cancer.
Prostatic Neoplasms
Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy.
Prostatic Neoplasms
Signaling pathway activated during apoptosis of the prostate cancer cell line LNCaP: overexpression of caspase-7 as a new gene therapy strategy for prostate cancer.
Pulmonary Disease, Chronic Obstructive
Elevated serum matrix metalloprotease (MMP-2) as a candidate biomarker for stable COPD.
Rectal Neoplasms
[Genetic variations in apoptosis genes are associated with acute adverse events in postoperative rectal cancer patients receiving concurrent chemoradiotherapy].
Reflex, Abnormal
Late-onset SCA2: 33 CAG repeats are sufficient to cause disease.
Retinal Degeneration
Caspase-7 ablation modulates UPR, reprograms TRAF2-JNK apoptosis and protects T17M rhodopsin mice from severe retinal degeneration.
Retinal Degeneration
Modulation of the Rate of Retinal Degeneration in T17M RHO Mice by Reprogramming the Unfolded Protein Response.
Salmonella Infections
Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes.
Sarcoma, Ewing
IFN-beta induces serine phosphorylation of Stat-1 in Ewing's sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7.
Seizures
Expression and differential processing of caspases 6 and 7 in relation to specific epileptiform EEG patterns following limbic seizures.
Sepsis
NLRP3 Inflammasome Deficiency Protects Against Microbial Sepsis via Increased Lipoxin B4 Synthesis.
Skin Neoplasms
Genetic ablation of caspase-7 promotes solar-simulated light-induced mouse skin carcinogenesis: the involvement of keratin-17.
Spastic Paraplegia, Hereditary
Spastic paraplegia, ataxia, mental retardation (SPAR): a novel genetic disorder.
Spinocerebellar Ataxias
An interrupted 34-CAG repeat SCA-2 allele in patients with sporadic spinocerebellar ataxia.
Spinocerebellar Ataxias
Cerebellar allografts survive and transiently alleviate ataxia in a transgenic model of spinocerebellar ataxia type-1.
Spinocerebellar Ataxias
Confirmation of the SCA-2 locus as an alternative locus for dominantly inherited spinocerebellar ataxias and refinement of the candidate region.
Spinocerebellar Ataxias
Damage to the reticulotegmental nucleus of the pons in spinocerebellar ataxia type 1, 2, and 3.
Spinocerebellar Ataxias
Genetic analysis of ten common degenerative hereditary ataxia loci in patients with essential tremor.
Spinocerebellar Ataxias
Structural and immunocytochemical features of olivopontocerebellar atrophy caused by the spinocerebellar ataxia type 1 (SCA-1) mutation define a unique phenotype.
Spinocerebellar Ataxias
Synapses in the hereditary ataxias.
Spinocerebellar Ataxias
Transglutaminase-dependent formation of protein aggregates as possible biochemical mechanism for polyglutamine diseases.
Starvation
Canavanine augments proapoptotic effects of arginine deprivation in cultured human cancer cells.
Stomach Neoplasms
Potentially Functional Polymorphisms in the CASP7 Gene Contribute to Gastric Adenocarcinoma Susceptibility in an Eastern Chinese Population.
Stomach Neoplasms
Prognostic significance of mRNA expression of CASPs in gastric cancer.
Stomach Neoplasms
Sine Oculis Homeobox Homolog 1 Regulates Mitochondrial Apoptosis Pathway Via Caspase-7 In Gastric Cancer Cells.
Uterine Cervical Neoplasms
CASP7 variants modify susceptibility to cervical cancer in Chinese women.
Vesicular Stomatitis
Requirement of caspase-3 for efficient apoptosis induction and caspase-7 activation but not viral replication or cell rounding in cells infected with vesicular stomatitis virus.
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Strausberg R.L.; Feingold E.A.; Grouse L.H.; Derge J.G.; et al.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
Proc. Natl. Acad. Sci. USA
99
16899-16903
2002
Homo sapiens (P55210), Mus musculus (P97864)
brenda
Garcia-Calvo, M.; Peterson, E.P.; Leiting, B.; Ruel, R.; Nicholson, D.W.; Thornberry, N.A.
Inhibition of human caspases by peptide-based and macromolecular inhibitors
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Homo sapiens
brenda
Garcia-Calvo, M.; Peterson, E.P.; Rasper, D.M.; Vaillancourt, J.P.; Zamboni, R.; Nicholson, D.W.; Thornberry, N.A.
Purification and catalytic properties of human caspase family members
Cell Death Differ.
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1999
Homo sapiens
brenda
Chang, H.Y.; Yang, X.
Proteases from cell suicide: functions and regulation of caspases
Microbiol. Mol. Biol. Rev.
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2000
Homo sapiens
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Thornberry, N.A.; Rano, T.A.; Peterson, E.P.; et al.
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
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Homo sapiens
brenda
Fernandes-Alnemri, T.; Armstrong, R.C.; Krebs, J.F.; Srinivasula, S.M.; Wang, L.; Bullrich, F.; Fritz, L.C.; Trapani, J.A.; Tomaselli, K.J.; Litwack, G.; Alnemri, E.S.
In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains
Proc. Natl. Acad. Sci. USA
93
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1996
Homo sapiens (P55210)
brenda
Eleouet, J.F.; Slee, E.A.; Saurini, F.; Castagne, N.; Poncet, D.; Garrido, C.; Solary, E.; Martin, S.J.
The viral nucleocapsid protein of transmissible gastroenteritis coronavirus (TGEV) is cleaved by caspase-6 and -7 during TGEV-induced apoptosis
J. Virol.
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2000
Homo sapiens
brenda
Talanian, R.V.; Quinlan, C.; Trautz, S.; Hackett, M.C.; Mankovich, J.A.; Banach, D.; Ghayur, T.; Brady, K.D.; Wong, W.W.
Substrate specificities of caspase family proteases
J. Biol. Chem.
272
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1997
Homo sapiens
brenda
Margolin, N.; Raybuck, S.A.; Wilson, K.P.; Chen, W.; Fox, T.; Gu, Y.; Livingston, D.J.
Substrate and inhibitor specificity of interleukin-1beta-converting enzyme and related caspases
J. Biol. Chem.
272
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1997
Homo sapiens
brenda
Bae, S.S.; Choi, J.H.; Oh, Y.S.; Perry, D.K.; Ryu, S.H.; Suh, P.G.
Proteolytic cleavage of epidermal growth factor receptor by caspases
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491
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2001
Homo sapiens
brenda
Kisselev, A.F.; Garcia-Calvo, M.; Overkleeft, H.S.; Peterson, E.; Pennington, M.W.; Ploegh, H.L.; Thornberry, N.A.; Goldberg, A.L.
the caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites
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2003
Homo sapiens
brenda
Lippke, J.A.; Gu, Y.; Sarnecki, C.; Caron, P.R.; Su, M.S.S.
Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32
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1996
Homo sapiens (P55210)
brenda
Fernandes-Alnemri, T.; Takahashi, A.; Armstrong, R.C.; Krebs, J.; Fritz, L.C.; Tomaselli, K.J.; Wang, L.; Yu, Z.; Croce, C.M.; Salveson, G.; Earnshaw, W.C.; Litwack, G.; Alnemri, E.S.
Mch3, a novel human apoptotic cysteine protease highly related to CPP32
Cancer Res.
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1995
Homo sapiens (P55210)
brenda
Juan, T.S.C.; McNiece, I.K.; Argento, J.M.; Jenkins, N.A.; Gilbert, D.J.; Copeland, N.G.; Fletcher, F.A.
Identification and mapping of Casp7, a cysteine protease resembling CPP32 beta, interleukin-1 beta converting enzyme, and CED-3
Genomics
40
86-93
1997
Homo sapiens (P55210), Homo sapiens, Mus musculus (P97864), Mus musculus
brenda
Machleidt, T.; Geller, P.; Schwandner, R.; Scherer, G.; Kronke, M.
Caspase 7-induced cleavage of kinectin in apoptotic cells
FEBS Lett.
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1998
Homo sapiens
brenda
Ethell, D.W.; Bossy-Wetzel, E.; Bredesen, D.E.
Caspase 7 can cleave tumor necrosis factor receptor-I (p60) at a non-consensus motif, in vitro
Biochim. Biophys. Acta
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2001
Homo sapiens
brenda
Riedl, S.J.; Fuentes-Prior, P.; Renatus, M.; Kairies, N.; Krapp, S.; Huber, R.; Salvesen, G.S.; Bode, W.
Structural basis for the activation of human procaspase-7
Proc. Natl. Acad. Sci. USA
98
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2001
Homo sapiens (P55210), Homo sapiens
brenda
Denault, J.B.; Salvesen, G.S.
Human caspase-7 activity and regulation by its N-terminal peptide
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2003
Homo sapiens
brenda
Duan, H.; Chinnaiyan, A.M.; Hudson, P.L.; Wing, J.P.; He, W.W.; Dixit, V.M.
ICE-LAP-3, a novel mammalian homologue at the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis
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271
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1996
Homo sapiens (P55210)
brenda
Chiu, C.C.; Lin, C.H.; Fang, K.
Etoposide (VP-16) sensitizes p53-deficient human non-small cell lung cancer cells to caspase-7-mediated apoptosis
Apoptosis
10
643-650
2005
Homo sapiens
brenda
Ohara, M.; Hayashi, T.; Kusunoki, Y.; Miyauchi, M.; Takata, T.; Sugai, M.
Caspase-2 and caspase-7 are involved in cytolethal distending toxin-induced apoptosis in Jurkat and MOLT-4 T-cell lines
Infect. Immun.
72
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2004
Homo sapiens
brenda
Sironi, J.J.; Ouchi, T.
STAT1-induced apoptosis is mediated by caspases 2, 3, and 7
J. Biol. Chem.
279
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2004
Homo sapiens
brenda
Clarke, C.A; Bennett, L.N.; Clarke, P.R.
Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway
J. Biol. Chem.
280
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2005
Homo sapiens, Xenopus laevis
brenda
Twiddy, D.; Cohen, G.M.; Macfarlane, M.; Cain, K.
Caspase-7 is directly activated by the approximately 700-kDa apoptosome complex and is released as a stable XIAP-caspase-7 approximately 200-kDa complex
J. Biol. Chem.
281
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2006
Homo sapiens
brenda
Fang, B.; Boross, P.I.; Tozser, J.; Weber, I.T.
Structural and kinetic analysis of caspase-3 reveals role for S5 binding site in substrate recognition
J. Mol. Biol.
360
654-666
2006
Homo sapiens
brenda
Houde, C.; Banks, K.G.; Coulombe, N.; Rasper, D.; Grimm, E.; Roy, S.; Simpson, E.M.; Nicholson, D.W.
Caspase-7 expanded function and intrinsic expression level underlies strain-specific brain phenotype of caspase-3-null mice
J. Neurosci.
24
9977-9984
2004
Homo sapiens, Mus musculus
brenda
Hayashi, N.; Shirakura, H.; Uehara, T.; Nomura, Y.
Relationship between SUMO-1 modification of caspase-7 and its nuclear localization in human neuronal cells
Neurosci. Lett.
397
5-9
2006
Homo sapiens
brenda
Goode, D.R.; Sharma, A.K.; Hergenrother, P.J.
Using peptidic inhibitors to systematically probe the S1 site of caspase-3 and caspase-7
Org. Lett.
7
3529-3532
2005
Homo sapiens
brenda
Chen, D.; Texada, D.E.; Duggan, C.; Deng, Y.; Redens, T.B.; Langford, M.P.
Caspase-3 and -7 mediate apoptosis of human Chang's conjunctival cells induced by enterovirus 70
Virology
347
307-322
2006
Homo sapiens
brenda
Jang, M.; Park, B.C.; Lee, A.Y.; Na, K.S.; Kang, S.; Bae, K.H.; Myung, P.K.; Chung, B.C.; Cho, S.; Lee, d.o.H.; Park, S.G.
Caspase-7 mediated cleavage of proteasome subunits during apoptosis
Biochem. Biophys. Res. Commun.
363
388-394
2007
Homo sapiens
brenda
Song, J.J.; Lee, Y.J.
Differential cleavage of Mst1 by caspase-7/-3 is responsible for TRAIL-induced activation of the MAPK superfamily
Cell. Signal.
20
892-906
2008
Homo sapiens
brenda
Agniswamy, J.; Fang, B.; Weber, I.T.
Plasticity of S2-S4 specificity pockets of executioner caspase-7 revealed by structural and kinetic analysis
FEBS J.
274
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2007
Homo sapiens
brenda
Young, J.E.; Gouw, L.; Propp, S.; Sopher, B.L.; Taylor, J.; Lin, A.; Hermel, E.; Logvinova, A.; Chen, S.F.; Chen, S.; Bredesen, D.E.; Truant, R.; Ptacek, L.J.; La Spada, A.R.; Ellerby, L.M.
Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation
J. Biol. Chem.
282
30150-30160
2007
Homo sapiens
brenda
Schweigreiter, R.; Stasyk, T.; Contarini, I.; Frauscher, S.; Oertle, T.; Klimaschewski, L.; Huber, L.A.; Bandtlow, C.E.
Phosphorylation-regulated cleavage of the reticulon protein Nogo-B by caspase-7 at a noncanonical recognition site
Proteomics
7
4457-4467
2007
Homo sapiens
brenda
Garcia-Lozano, J.R.; Torres, B.; Fernandez, O.; Orozco, G.; Alvarez-Marquez, A.; Garcia, A.; Gonzalez-Gay, M.A.; Garcia, A.; Nunez-Roldan, A.; Martin, J.; Gonzalez-Escribano, M.F.
Caspase 7 influences susceptibility to rheumatoid arthritis
Rheumatology
46
1243-1247
2007
Homo sapiens
brenda
Li, I.T.; Pham, E.; Chiang, J.J.; Truong, K.
FRET evidence that an isoform of caspase-7 binds but does not cleave its substrate
Biochem. Biophys. Res. Commun.
373
325-329
2008
Homo sapiens
brenda
Podichetty, A.K.; Faust, A.; Kopka, K.; Wagner, S.; Schober, O.; Schaefers, M.; Haufe, G.
Fluorinated isatin derivatives. Part 1: synthesis of new N-substituted (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatins as potent caspase-3 and -7 inhibitors
Bioorg. Med. Chem.
17
2680-2688
2009
Homo sapiens
brenda
Chan, Q.K.; Ngan, H.Y.; Ip, P.P.; Liu, V.W.; Xue, W.C.; Cheung, A.N.
Tumor suppressor effect of follistatin-like 1 in ovarian and endometrial carcinogenesis: a differential expression and functional analysis
Carcinogenesis
30
114-121
2009
Homo sapiens
brenda
Hashimoto, T.; Yamauchi, L.; Hunter, T.; Kikkawa, U.; Kamada, S.
Possible involvement of caspase-7 in cell cycle progression at mitosis
Genes Cells
13
609-621
2008
Homo sapiens
brenda
Frydrych, I.; Mlejnek, P.
Serine protease inhibitors N-alpha-tosyl-L-lysinyl-chloromethylketone (TLCK) and N-tosyl-L-phenylalaninyl-chloromethylketone (TPCK) do not inhibit caspase-3 and caspase-7 processing in cells exposed to pro-apoptotic inducing stimuli
J. Cell. Biochem.
105
1501-1506
2008
Homo sapiens
brenda
Bressenot, A.; Marchal, S.; Bezdetnaya, L.; Garrier, J.; Guillemin, F.; Plenat, F.
Assessment of apoptosis by immunohistochemistry to active caspase-3, active caspase-7, or cleaved PARP in monolayer cells and spheroid and subcutaneous xenografts of human carcinoma
J. Histochem. Cytochem.
57
289-300
2009
Homo sapiens
brenda
Jung, E.J.; Kim, D.R.
Apoptotic cell death in TrkA-overexpressing cells: kinetic regulation of ERK phosphorylation and caspase-7 activation
Mol. Cells
26
12-17
2008
Homo sapiens
brenda
Jang, M.; Park, B.C.; Kang, S.; Lee, d.o..H.; Cho, S.; Lee, S.C.; Bae, K.H.; Park, S.G.
Mining of caspase-7 substrates using a degradomic approach
Mol. Cells
26
152-157
2008
Homo sapiens
brenda
Bondarava, M.; Li, T.; Endl, E.; Wehner, F.
alpha-ENaC is a functional element of the hypertonicity-induced cation channel in HepG2 cells and it mediates proliferation
Pflugers Arch.
458
675-687
2009
Homo sapiens
brenda
Stegh, A.H.; Kesari, S.; Mahoney, J.E.; Jenq, H.T.; Forloney, K.L.; Protopopov, A.; Louis, D.N.; Chin, L.; DePinho, R.A.
Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma
Proc. Natl. Acad. Sci. USA
105
10703-10708
2008
Homo sapiens
brenda
Walsh, J.G.; Cullen, S.P.; Sheridan, C.; Luethi, A.U.; Gerner, C.; Martin, S.J.
Executioner caspase-3 and caspase-7 are functionally distinct proteases
Proc. Natl. Acad. Sci. USA
105
12815-12819
2008
Homo sapiens, Mus musculus
brenda
Karki, P.; Dahal, G.R.; Shin, S.Y.; Lee, J.S.; Cho, B.; Park, I.S.
Efficient cleavage of Bid and procaspase-7 by caspase-2 at lower pH
Protein Pept. Lett.
15
1044-1049
2008
Homo sapiens
brenda
Agniswamy, J.; Fang, B.; Weber, I.T.
Conformational similarity in the activation of caspase-3 and -7 revealed by the unliganded and inhibited structures of caspase-7
Apoptosis
14
1135-1144
2009
Homo sapiens
brenda
Lee, Y.M.; Kang, H.J.; Jang, M.; Kim, M.; Bae, K.H.; Chung, S.J.
Large-scale expression in Escherichia coli and efficient purification of precursor and active caspase-7 by introduction of thrombin cleavage sites
Protein Expr. Purif.
69
29-33
2010
Homo sapiens
brenda
Soares, J.; Lowe, M.M.; Jarstfer, M.B.
The catalytic subunit of human telomerase is a unique caspase-6 and caspase-7 substrate
Biochemistry
50
9046-9055
2011
Homo sapiens
brenda
Edelmann, B.; Bertsch, U.; Tchikov, V.; Winoto-Morbach, S.; Perrotta, C.; Jakob, M.; Adam-Klages, S.; Kabelitz, D.; Schuetze, S.
Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes
EMBO J.
30
379-394
2011
Homo sapiens
brenda
Majerciak, V.; Kruhlak, M.; Dagur, P.K.; McCoy, J.P.; Zheng, Z.M.
Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression
J. Biol. Chem.
285
11297-11307
2010
Homo sapiens
brenda
Nakatsumi, H.; Yonehara, S.
Identification of functional regions defining different activity in caspase-3 and caspase-7 within cells
J. Biol. Chem.
285
25418-25425
2010
Homo sapiens (P55210), Homo sapiens
brenda
Miscione, G.P.; Calvaresi, M.; Bottoni, A.
Computational evidence for the catalytic mechanism of caspase-7. A DFT investigation
J. Phys. Chem. B
114
4637-4645
2010
Homo sapiens
brenda
Mills, E.; Chen, X.; Pham, E.; Wong, S.; Truong, K.
Engineering a photoactivated caspase-7 for rapid induction of apoptosis
ACS Synth. Biol.
1
75-82
2012
Homo sapiens
brenda
Cassel, J.A.; McDonnell, M.E.; Velvadapu, V.; Andrianov, V.; Reitz, A.B.
Characterization of a series of 4-aminoquinolines that stimulate caspase-7 mediated cleavage of TDP-43 and inhibit its function
Biochimie
94
1974-1981
2012
Homo sapiens
brenda
Boucher, D.; Blais, V.; Denault, J.B.
Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis
Proc. Natl. Acad. Sci. USA
109
5669-5674
2012
Homo sapiens (P55210)
brenda
Hill, M.E.; MacPherson, D.J.; Wu, P.; Julien, O.; Wells, J.A.; Hardy, J.A.
Reprogramming caspase-7 specificity by regio-specific mutations and selection provides alternate solutions for substrate recognition
ACS Chem. Biol.
11
1603-1612
2016
Homo sapiens (P55210), Homo sapiens
brenda
Vance, N.R.; Gakhar, L.; Spies, M.A.
Allosteric tuning of caspase-7 A fragment-based drug discovery approach
Angew. Chem. Int. Ed. Engl.
56
14443-14447
2017
Homo sapiens (P55210), Homo sapiens
brenda
Martini, C.; Bedard, M.; Lavigne, P.; Denault, J.B.
Characterization of Hsp90 co-chaperone p23 cleavage by caspase-7 uncovers a peptidase-substrate interaction involving intrinsically disordered regions
Biochemistry
56
5099-5111
2017
Homo sapiens (P55210)
brenda
Bingoel, E.N.; Sercinoglu, O.; Ozbek, P.
How do mutations and allosteric inhibitors modulate caspase-7 activity? A molecular dynamics study
J. Biomol. Struct. Dyn.
37
3456-3466
2019
Homo sapiens (P55210)
brenda