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Information on EC 3.4.22.42 - cathepsin O and Organism(s) Homo sapiens

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.42 cathepsin O
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This record set is specific for:
Homo sapiens
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
cathepsin o, procathepsin o, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
procathepsin O
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
162032-86-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Fibrinogen + H2O
?
show the reaction diagram
-
-
-
-
?
N-benzyloxycarbonyl-L-Arg-L-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-L-Arg-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
N-benzyloxycarbonyl-L-Phe-L-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
additional information
?
-
-
role in intracellular protein degradation
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
role in intracellular protein degradation
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane
-
i.e. E-64
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CATO_HUMAN
321
0
35958
Swiss-Prot
Secretory Pathway (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
23400
-
active, processed enzyme, calculation from sequence of cDNA
35880
-
preproprotein, composed of a signal peptide, a proprotein and the mature enzyme, calculation from sequence of cDNA
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glycoprotein
-
two potential N-glycosylation sites, both located in the proregion
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Santamaria, I.; Pendas, A.M.; Lopez-Otin, C.
Genomic structure and chromosomal localization of a human cathepsin O gene (CTSO)
Genomics
53
231-234
1998
Homo sapiens
Manually annotated by BRENDA team
Velasco, G.; Ferrando, A.A.; Puente, X.S.; Sanchez, L.M.; Lopez-Otin, C.
Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues
J. Biol. Chem.
269
27136-27142
1994
Homo sapiens
Manually annotated by BRENDA team
Shi, G.P.; Chapman, H.A.; Bhairi, S.M.; DeLeeuwe, C.; Reddy, V.Y.; Weiss, S.J.
Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2
FEBS Lett.
357
129-134
1995
Homo sapiens
Manually annotated by BRENDA team
Reif, M.M.; Mach, L.; Oostenbrink, C.
Molecular insight into propeptide-protein interactions in cathepsins L and O
Biochemistry
51
8636-8653
2012
Homo sapiens
Manually annotated by BRENDA team