Reference on EC 3.4.22.32 - Stem bromelain
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rowan, A.D.; Buttle, D.J.; Barrett, A.J.
Ananain: a novel cysteine proteinase found in pineapple stem
Arch. Biochem. Biophys.
267
262-270
1988
BRENDA: Ananas comosus
Textmining: Gallus gallus
Rowan, A.D.; Buttle, D.J.; Barrett, A.J.
The cysteine proteinases of the pineapple plant
Biochem. J.
266
869-875
1990
BRENDA: Ananas comosus
Textmining: plant
Rowan, A.D.; Buttle, D.J.
Pineapple cysteine endopeptidases
Methods Enzymol.
244
555-568
1994
Ananas comosus
Napper, A.D.; Bennett, S.P.; Borowski, M.; Holridge, M.B.; Leonard, M.J.C.; Rogers, E.E.; Duan, Y.; Laursen, R.A.; Reinhold, B.; Shames, S.L.
Purification and characterization of multiple forms of the pineapple-stem-derived cysteine proteinases ananain and comosain
Biochem. J.
301
727-735
1994
Ananas comosus
Heinrikson, R.L.; Kezdy, F.J.
Acidic cysteine protease inhibitors from pineapple stem
Methods Enzymol.
45
740-751
1976
Ananas comosus
Ritonja, A.; Rowan, A.D.; Buttle, D.J.; Rawlings, N.D.; Turk, V.; Barrett, A.J.
Stem bromelain: amino acid sequence and implications for weak binding of cystatin
FEBS Lett.
247
419-424
1989
Ananas comosus
Ota, S.; Horie, K.; Hagino, F.; Hashimoto, C.; Date, H.
Fractionation and some properties of the proteolytically active components of bromelains in the stem and the fruit of the pineapple plant
J. Biochem.
71
817-830
1972
Ananas comosus
Ota, S.; Muta, E.; Katahira, Y.; Okamoto, Y.
Reinvestigation of fractionation and some properties of the proteolytically active components of stem and fruit bromelains
J. Biochem.
98
219-228
1985
Ananas comosus
Rowan, A.D.; Brzin, J.; Buttle, D.J.; Barrett, A.J.
Inhibition of cysteine proteinases by a protein inhibitor from potato
FEBS Lett.
269
328-330
1990
BRENDA: Ananas comosus
Textmining: Solanum tuberosum
Arroyo-Reyna, A.; Hernandez-Arana, A.
The thermal denaturation of stem bromelain is consistent with an irreversible two-state model
Biochim. Biophys. Acta
1248
123-128
1995
Ananas comosus
Goto, K.; Murachi, T.; Takahashi, N.
Structural studies on stem bromelain isolation, characterization and alignment of the cyanogen bromide fragments
FEBS Lett.
62
93-95
1976
Ananas comosus
Silverstein, R.M.; Kezdy, F.J.
Characterization of the pineapple stem proteases (bromelains)
Arch. Biochem. Biophys.
167
678-686
1975
Ananas comosus
Wharton, C.W.
The structure and mechanism of stem bromelain. Evaluation of the homogeneity of purified stem bromelain, determination of the molecular weight and kinetic analysis of the bromelain-catalysed hydrolysis of N-benzyloxycarbonyl-L-phenylalanyl-L-serine methyl ester
Biochem. J.
143
575-586
1974
Ananas comosus
Wharton, C.W.; Cornish-Bowden, A.; Brocklehurst, K.; Crook, E.M.
Kinetics of the hydrolysis of N-benzoyl-L-serine methyl ester catalysed by bromelain and by papain. Analysis of modifier mechanisms by lattice nomography, computational methods of parameter evaluation for substrate-activated catalyses and consequences of postulated non-productive binding in bromelain- and papain-catalysed hydrolyses
Biochem. J.
141
365-381
1974
Ananas comosus
Minami, Y.; Doi, E.; Hata, T.
Fractionation, purification, and some properties of proteolytic enzymes from stem bromelain
Agric. Biol. Chem.
35
1419-1430
1971
Ananas comosus
-
Murachi, T.; Tsudzuki, T.; Okumura, K.
Photosensitized inactivation of stem bromelain. Oxidation of histidine, methionine, and tryptophan residues
Biochemistry
14
249-255
1975
Ananas comosus
Takahashi, N.; Yasuda, Y.; Goto, K.; Miyake, T.; Murachi, T.
Multiple molecular forms of stem bromelain. Isolation and characterization of two closely related components, SB1 and SB2
J. Biochem.
74
355-373
1973
Ananas comosus
Carey, P.R.; Ozaki, Y.; Storer, A.C.
Comparison of the substrate conformations in the active sites of papain, chymopapain, ficin and bromelain by resonance Raman spectroscopy
Biochem. Biophys. Res. Commun.
117
725-731
1983
Ananas comosus
Gray, C.J.; Boukouvalas, J.; Szawelski, R.J.; Wharton, C.W.
Benzyloxycarbonylphenylalanylcitrulline p-nitroanilide as a substrate for papain and other plant cysteine proteinases
Biochem. J.
219
325-328
1984
Ananas comosus
Shipton, M.; Brocklehurst, K.
Benzofuroxan as a thiol-specific reactivity probe. Kinetics of its reactions with papain, ficin, bromelain and low-molecular-weight thiols
Biochem. J.
167
799-810
1977
BRENDA: Ananas comosus
Textmining: Electron
Shipton, M.; Stuchbury, T.; Brocklehurst, K.
4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole as a reactivity probe for the investigation of the thiol proteinases. evidence that ficin and bromelain may lack carboxyl groups conformationally equivalent to that of aspartic acid-158 of papain
Biochem. J.
159
235-244
1976
Ananas comosus
Bobb, D.
Isolation of stem bromelain by affinity chromatography and its partial characterization by gel electrophoresis
Prep. Biochem.
2
347-354
1972
Ananas comosus
Lenarcic, B.; Ritonja, A.; Turk, B.; Dolenc, I.; Turk, V.
Characterization and structure of pineapple stem inhibitor of cysteine proteinases
Biol. Chem. Hoppe-Seyler
373
459-464
1992
Ananas comosus
Dickson, S.R.; Bickerstaff, G.F.
Properties of immobilized bromelain
Biochem. Soc. Trans.
20
23S
1992
Ananas comosus
Harrach, T.; Eckert, K.; Schulze-Forster, K.; Nuck, R.; Grunow, D.; Maurer, H.R.
Isolation and partial characterization of basic proteinases from stem bromelain
J. Protein Chem.
14
41-52
1995
Ananas comosus
Suh, H.J.; Lee, H.; Cho, H.Y.; Yang, H.C.
Purification and characterization of bromelain isolated from pineapple
Han'guk Nonghwa Hakhoechi
35
300-307
1992
Ananas comosus
-
Ko, Y.H.; Kang, Y.J.
Isolation and partial characterization of proteolytic enzymes from stems of pineapples cultivated in Cheju Island
Nonmunjip-Cheju Taehakkyo, Chayon Kwahakpyon
31
137-142
1990
Ananas comosus
-
Goto, K.; Takahashi, N.; Murachi, T.
Structural studies on stem bromelain. Cyanogen bromide cleavage and amino acid sequence of carboxyl-terminal half of the molecule
Int. J. Pept. Protein Res.
15
335-341
1980
Ananas comosus
Crankshaw, D.L.; Hetnarski, K.; Wilkinson, C.F.
Purification and characterization of NADPH--cytochrome c reductase from the midgut of the southern armyworm (Spodoptera eridania)
Biochem. J.
181
593-605
1979
Spodoptera eridania
Ishihara, H.; Takahashi, N.; Oguri, S.; Tejima, S.
Complete structure of the carbohydrate moiety of stem bromelain. An application of the almond glycopeptidase for structural studies of glycopeptides
J. Biol. Chem.
254
10715-10719
1979
Prunus dulcis
Takahashi, N.; Nishibe, H.
Almond glycopeptidase acting on aspartylglycosylamine linkages. Multiplicity and substrate specificity
Biochim. Biophys. Acta
657
457-467
1981
Homo sapiens
Tate, S.S.; Ross, M.E.
Human kidney gamma-glutamyl transpeptidase. Catalytic properties, subunit structure, and localization of the gamma-glutamyl binding site on the light subunit
J. Biol. Chem.
252
6042-6045
1977
Homo sapiens
Pascual, I.; Gil-Parrado, S.; Cisneros, M.; Joseph-Bravo, P.; Diaz, J.; Possani, L.D.; Charli, J.L.; Chavez, M.
Purification of a specific inhibitor of pyroglutamyl aminopeptidase II from the marine annelide Hermodice carunculata. in vivo effects in rodent brain
Int. J. Biochem. Cell Biol.
36
138-152
2004
Human immunodeficiency virus 1
Rasheedi, S.; Haq, S.K.; Khan, R.H.
Guanidine hydrochloride denaturation of glycosylated and deglycosylated stem bromelain
Biochemistry
68
1097-1100
2003
Ananas comosus
Hatano, K.; Sawano, Y.; Tanokura, M.
Structure-function relationship of bromelain isoinhibitors from pineapple stem
Biol. Chem.
383
1151-1156
2002
Ananas comosus
Maurer, H.R.
Bromelain: biochemistry, pharmacology and medical use
Cell. Mol. Life Sci.
58
1234-1245
2001
Ananas comosus, Homo sapiens
Haq, S.K.; Rasheedi, S.; Khan, R.H.
Characterization of a partially folded intermediate of stem bromelain at low pH
Eur. J. Biochem.
269
47-52
2002
Ananas comosus
Hatano, K.; Tanokura, M.; Takahashi, K.
The amino acid sequences of isoforms of the bromelain inhibitor from pineapple stem
J. Biochem.
124
457-461
1998
Ananas comosus
Khan, R.H.; Rasheedi, S.; Haq, S.K.
Effect of pH, temperature and alcohols on the stability of glycosylated and deglycosylated stem bromelain
J. Biosci.
28
709-714
2003
Ananas comosus
Harrach, T.; Eckert, K.; Maurer, H.R.; Machleidt, I.; Machleidt, W.; Nuck, R.
Isolation and characterization of two forms of an acidic bromelain stem proteinase
J. Protein Chem.
17
351-361
1998
BRENDA: Ananas comosus
Textmining: Gallus gallus
Gaspani, L.; Limiroli, E.; Ferrario, P.; Bianchi, M.
In vivo and in vitro effects of bromelain on PGE2 and SP concentrations in the inflammatory exudate in rats
Pharmacology
65
83-86
2002
BRENDA: Ananas comosus
Textmining: Rattus
Westphal, S.; Kolarich, D.; Foetisch, K.; Lauer, I.; Altmann, F.; Conti, A.; Crespo, J.F.; Rodriguez, J.; Enrique, E.; Vieths, S.; Scheurer, S.
Molecular characterization and allergenic activity of Lyc e 2 (beta-fructofuranosidase), a glycosylated allergen of tomato
Eur. J. Biochem.
270
1327-1337
2003
Ananas comosus
Gupta, P.; Saleemuddin, M.; Khan, R.H.
Hydrophobic interactions are the prevalent force in bromelain:Fab complex
Biochemistry
71
S31-S37
2006
Ananas comosus
-
Ahmad, B.; Ansari, M.A.; Sen, P.; Khan, R.H.
Low versus high molecular weight poly(ethylene glycol)-induced states of stem bromelain at low pH: stabilization of molten globule and unfolded states
Biopolymers
81
350-359
2006
Ananas comosus
Gupta, P.; Saleemuddin, M.
Bioaffinity based oriented immobilization of stem bromelain
Biotechnol. Lett.
28
917-922
2006
BRENDA: Ananas comosus
Textmining: plant
Rowan, A.D.
Stem bromelain
Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press
2
1136-1137
2004
Ananas comosus
-
Hale, L.P.
Proteolytic activity and immunogenicity of oral bromelain within the gastrointestinal tract of mice
Int. Immunopharmacol.
4
255-264
2004
BRENDA: Ananas comosus
Textmining: Mus sp., Mus musculus
Hale, L.P.; Greer, P.K.; Trinh, C.T.; James, C.L.
Proteinase activity and stability of natural bromelain preparations
Int. Immunopharmacol.
5
783-793
2005
Ananas comosus, Homo sapiens, animal
Haq, S.K.; Rasheedi, S.; Sharma, P.; Ahmad, B.; Khan, R.H.
Influence of salts and alcohols on the conformation of partially folded intermediate of stem bromelain at low pH
Int. J. Biochem. Cell Biol.
37
361-374
2005
Ananas comosus
Juhasz, B.; Thirunavukkarasu, M.; Pant, R.; Zhan, L.; Penumathsa, S.V.; Secor, E.R.; Srivastava, S.; Raychaudhuri, U.; Menon, V.P.; Otani, H.; Thrall, R.S.; Maulik, N.
Bromelain induces cardioprotection against ischemia-reperfusion injury through Akt/FOXO pathway in rat myocardium
Am. J. Physiol. Heart Circ. Physiol.
294
H1365-H1370
2008
BRENDA: Ananas comosus
Textmining: Rattus
Anwar, T.; Ahmad, B.; Younus, H.
Cross-linked stem bromelain: A more stabilized active preparation
Biocatal. Biotransform.
25
453-458
2007
Ananas comosus
-
Mahmood, R.; Saleemuddin, M.
Additional stabilization of stem bromelain coupled to a thermosensitive polymer by uniform orientation and using polyclonal antibodies
Biochemistry (Moscow)
72
307-312
2007
Ananas comosus
Grabovac, V.; Bernkop-Schnuerch, A.
Improvement of the intestinal membrane permeability of low molecular weight heparin by complexation with stem bromelain
Int. J. Pharm.
326
153-159
2006
BRENDA: Ananas comosus
Textmining: Rattus
Ahmad, B.; Khan, R.H.
Studies on the acid unfolded and molten globule states of catalytically active stem bromelain: A comparison with catalytically inactive form
J. Biochem.
140
501-508
2006
BRENDA: Ananas comosus
Textmining: Ananas
Ahmad, B.; Shamim, T.A.; Haq, S.K.; Khan, R.H.
Identification and characterization of functional intermediates of stem bromelain during urea and guanidine hydrochloride unfolding
J. Biochem.
141
251-259
2007
Ananas comosus
Gupta, P.; Maqbool, T.; Saleemuddin, M.
Oriented immobilization of stem bromelain via the lone histidine on a metal affinity support
J. Mol. Catal. B
45
78-83
2007
Ananas comosus
-
Baez, R.; Lopes, M.T.; Salas, C.E.; Hernandez, M.
In vivo antitumoral activity of stem pineapple (Ananas comosus) bromelain
Planta Med.
73
1377-1383
2007
BRENDA: Ananas comosus
Textmining: Ananas, Mus sp., Metazoa
Habib, S.; Khan, M.A.; Younus, H.
Thermal destabilization of stem bromelain by trehalose
Protein J.
26
117-124
2007
Ananas comosus
Khatoon, H.; Younus, H.; Saleemuddin, M.
Stem bromelain: an enzyme that naturally facilitates oriented immobilization
Protein Pept. Lett.
14
233-236
2007
Ananas comosus (P14518)
Kalra, N.; Bhui, K.; Roy, P.; Srivastava, S.; George, J.; Prasad, S.; Shukla, Y.
Regulation of p53, nuclear factor kappaB and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin
Toxicol. Appl. Pharmacol.
226
30-37
2008
BRENDA: Ananas comosus
Textmining: Mus musculus
Bhattacharya, R.; Bhattacharyya, D.
Resistance of bromelain to SDS binding
Biochim. Biophys. Acta
1794
698-708
2009
BRENDA: Ananas comosus
Textmining: plant
Bhui, K.; Prasad, S.; George, J.; Shukla, Y.
Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway
Cancer Lett.
282
167-176
2009
BRENDA: Ananas comosus
Textmining: Mus musculus
Fitzhugh, D.J.; Shan, S.; Dewhirst, M.W.; Hale, L.P.
Bromelain treatment decreases neutrophil migration to sites of inflammation
Clin. Immunol.
128
66-74
2008
BRENDA: Ananas comosus
Textmining: Mus musculus
Secor, E.R.; Carson, W.F.; Singh, A.; Pensa, M.; Guernsey, L.A.; Schramm, C.M.; Thrall, R.S.
Oral bromelain attenuates inflammation in an ovalbumin-induced murine model of asthma
Evid. Based. Complement Alternat. Med.
5
61-69
2008
BRENDA: Ananas comosus
Textmining: Mus musculus, Homo sapiens, Mus sp.
Secor, E.R.; Singh, A.; Guernsey, L.A.; McNamara, J.T.; Zhan, L.; Maulik, N.; Thrall, R.S.
Bromelain treatment reduces CD25 expression on activated CD4+ T cells in vitro
Int. Immunopharmacol.
9
340-346
2009
Ananas comosus
Dave, S.; Mahajan, S.; Chandra, V.; Dkhar, H.K.; Sambhavi, H.K.; Gupta, P.
Specific molten globule conformation of stem bromelain at alkaline pH
Arch. Biochem. Biophys.
499
26-31
2010
Ananas comosus
Ahmad, B.; Rathar, G.M.; Varshney, A.; Khan, R.H.
pH-Dependent urea-induced unfolding of stem bromelain: Unusual stability against urea at neutral pH
Biochemistry
74
1337-1343
2009
Ananas comosus
Chobotova, K.; Vernallis, A.B.; Majid, F.A.
Bromelain's activity and potential as an anti-cancer agent: Current evidence and perspectives
Cancer Lett.
290
148-156
2010
Ananas comosus
Salampessy, J.; Phillips, M.; Seneweera, S.; Kailasapathy, K.
Release of antimicrobial peptides through bromelain hydrolysis of leatherjacket (Meuchenia sp.) insoluble proteins
Food Chem.
120
556-560
2010
Ananas comosus
Dave, S.; Dkhar, H.K.; Singh, M.P.; Gupta, G.; Chandra, V.; Mahajan, S.; Gupta, P.
Hexafluoroisopropanol-induced helix-sheet transition of stem bromelain: correlation to function
Int. J. Biochem. Cell Biol.
42
938-947
2010
BRENDA: Ananas comosus
Textmining: Mus musculus, Transformation
Xue, Y.; Wu, C.; Branford-White, C.; Ning, X.; Nie, H.; Zhu, L.
Chemical modification of stem bromelain with anhydride groups to enhance its stability and catalytic activity
J. Mol. Catal. B
63
188-193
2010
Ananas comosus
-
Valdes-Rodriguez, S.; Cedro-Tanda, A.; Aguilar-Hernandez, V.; Cortes-Onofre, E.; Blanco-Labra, A.; Guerrero-Rangel, A.
Recombinant amaranth cystatin (AhCPI) inhibits the growth of phytopathogenic fungi
Plant Physiol. Biochem.
48
469-475
2010
Amaranthus caudatus
Neuteboom, L.W.; Matsumoto, K.O.; Christopher, D.A.
An extended AE-rich N-terminal trunk in secreted pineapple cystatin enhances inhibition of fruit bromelain and is posttranslationally removed during ripening
Plant Physiol.
151
515-527
2009
Ananas comosus, Ananas comosus (O23791)
Ferreira, J.; Bresolin, L.; Silveira, E.; Tambourgi, E.
Purification of bromelain from ananas comosus by PEG/phosphate ATPS
Chem. Eng. Transact.
24
931-936
2011
Ananas comosus
-
Yin, L.; Sun, C.; Han, X.; Xu, L.; Xu, Y.; Qi, Y.; Peng, J.
Preparative purification of bromelain (EC 3.4.22.33) from pineapple fruit by high-speed counter-current chromatography using a reverse-micelle solvent system
Food Chem.
129
925-932
2011
Ananas comosus
Dave, S.; Mahajan, S.; Chandra, V.; Gupta, P.
Trifluoroethanol stabilizes the molten globule state and induces non-amyloidic turbidity in stem bromelain near its isoelectric point
Int. J. Biol. Macromol.
49
536-542
2011
BRENDA: Ananas comosus
Textmining: Transformation
Esti, M.; Benucci, I.; Liburdi, K.; Garzillo, A.M.
Effect of wine inhibitors on free pineapple stem bromelain activity in a model wine system
J. Agric. Food Chem.
59
3391-3397
2011
Ananas comosus
Amid, A.; Ismail, N.; Yusof, F.; Salleh, H.
Expression, purification, and characterization of a recombinant stem bromelain from Ananas comosus
Process Biochem.
46
2232-2239
2011
Ananas comosus
-
Arshad, Z.I.; Amid, A.; Yusof, F.; Jaswir, I.; Ahmad, K.; Loke, S.P.
Bromelain: an overview of industrial application and purification strategies
Appl. Microbiol. Biotechnol.
98
7283-7297
2014
Ananas comosus, Ananas comosus (O23791)
Ilaria, B.; Marco, E.; Katia, L.; Maria Vittoria, G.A.
Pineapple stem bromelain immobilized on different supports: catalytic properties in model wine
Biotechnol. Prog.
28
1472-1477
2012
Ananas comosus
Pavan, R.; Jain, S.; Shraddha, S.; Kumar, A.
Properties and therapeutic application of bromelain: a review
Biotechnol. Res. Int.
2012
976203
2012
Ananas comosus
Secor, E.R.; Szczepanek, S.M.; Singh, A.; Guernsey, L.; Natarajan, P.; Rezaul, K.; Han, D.K.; Thrall, R.S.; Silbart, L.K.
LC-MS/MS Identification of a Bromelain Peptide Biomarker from Ananas comosus Merr
Evid. Based. Complement Alternat. Med.
2012
548486
2012
Ananas comosus, Mus musculus
Esti, M.; Benucci, I.; Liburdi, K.; Garzillo, A.
Immobilized pineapple stem bromelain activity in a wine-like medium: Effect of inhibitors
Food Bioprod. Process.
93
84-89
2015
Ananas comosus
-
Rani, A.; Venkatesu, P.
Insights into the interactions between enzyme and co-solvents: stability and activity of stem bromelain
Int. J. Biol. Macromol.
73
189-201
2015
Ananas comosus
Lopez-Garcia, B.; Hernandez, M.; Segundo, B.S.
Bromelain, a cysteine protease from pineapple (Ananas comosus) stem, is an inhibitor of fungal plant pathogens
Lett. Appl. Microbiol.
55
62-67
2012
Ananas comosus
George, S.; Bhasker, S.; Madhav, H.; Nair, A.; Chinnamma, M.
Functional characterization of recombinant bromelain of Ananas comosus expressed in a prokaryotic system
Mol. Biotechnol.
56
166-174
2014
Ananas comosus
Banks, J.M.; Herman, C.T.; Bailey, R.C.
Bromelain decreases neutrophil interactions with P-selectin, but not E-selectin, in vitro by proteolytic cleavage of P-selectin glycoprotein ligand-1
PLoS ONE
8
e78988
2013
BRENDA: Ananas comosus
Textmining: Homo sapiens
Esti, M.; Benucci, I.; Lombardelli, C.; Liburdi, K.; Garzillo, A.
Papain from papaya (Carica papaya L.) fruit and latex: Preliminary characterization in alcoholic-acidic buffer for wine application
Food Bioprod. Process.
91
595-598
2013
Ananas comosus
Al-Otaibi, W.R.; Virk, P.; Elobeid, M.
Ameliorative potential of stem bromelain on lead-induced toxicity in Wistar rats
Acta Biol. Hung.
66
149-160
2015
BRENDA: Ananas comosus
Textmining: Rattus norvegicus
Misran, E.; Idris, A.; Mat Sarip, S.; Yaakob, H.
Properties of bromelain extract from different parts of the pineapple variety Morris
Biocatal. Agricult. Biotechnol.
18
101095
2019
Ananas comosus
-
Yongqing, T.; Wilmann, P.G.; Pan, J.; West, M.L.; Brown, T.J.; Mynott, T.; Pike, R.N.; Wijeyewickrema, L.C.
Determination of the crystal structure and substrate specificity of ananain
Biochimie
166
194-202
2019
Ananas comosus
Torres, M.J.; Natalucci, C.; Lopez, L.M.I.; Trejo, S.A.
Insights into the hydrolytic activity of Asclepias fruticosa L. protease
Biotechnol. Lett.
41
1043-1050
2019
plant
Manosroi, W.; Chankhampan, C.; Manosroi, J.; Manosroi, A.
In vitro anti-cancer activity comparison of the freeze-dried and spray-dried bromelain from pineapple stems
Chiang Mai J. Sci.
44
1407-1418
2017
Ananas comosus (P14518)
-
Ramli, A.N.M.; Manas, N.H.A.; Hamid, A.A.A.; Hamid, H.A.; Illias, R.M.
Comparative structural analysis of fruit and stem bromelain from Ananas comosus
Food Chem.
266
183-191
2018
Ananas comosus (P14518), Ananas comosus
Meza-Espinoza, L.; de Los Angeles Vivar-Vera, M.; de Lourdes Garcia-Magana, M.; Sayago-Ayerdi, S.G.; Chacon-Lopez, A.; Becerrea-Verdin, E.M.; Montalvo-Gonzalez, E.
Enzyme activity and partial characterization of proteases obtained from Bromelia karatas fruit and compared with Bromelia pinguin proteases
Food Sci. Biotechnol.
27
509-517
2018
Bromelia pinguin, Bromelia karatas
Tap, F.; Majid, F.; Khairudin, N.
Structure prediction of stem bromelain from pineapples (Ananas comosus) using procaricain enzyme as a modelling template
Int. J. Appl. Eng. Res.
11
6109-6111
2016
Ananas comosus (F1KD58)
-
Bhakuni, K.; Venkatesu, P.
Does macromolecular crowding compatible with enzyme stem bromelain structure and stability?
Int. J. Biol. Macromol.
131
527-535
2019
Ananas comosus (P14518)
Sao Paulo Barretto Miranda, I.K.; Fontes Suzart Miranda, A.; Souza, F.V.; Vannier-Santos, M.A.; Pirovani, C.P.; Pepe, I.M.; Rodowanski, I.J.; Ferreira, K.T.; Mendes Souza Vaz, L.; de Assis, S.A.
The biochemical characterization, stabilization studies and the antiproliferative effect of bromelain against B16F10 murine melanoma cells
Int. J. Food Sci. Nutr.
68
442-454
2017
BRENDA: Ananas comosus (P14518), Ananas comosus, Ananas comosus AGB 772 (P14518)
Textmining: Mus musculus
Das, S.; Bhattacharyya, D.
Destabilization of human insulin fibrils by peptides of fruit bromelain derived from Ananas comosus (pineapple)
J. Cell. Biochem.
118
4881-4896
2017
Homo sapiens
Ghensi, P.; Cucchi, A.; Bonaccorso, A.; Ferroni, L.; Gardin, C.; Mortellaro, C.; Zavan, B.
In vitro effect of bromelain on the regenerative properties of mesenchymal stem cells
J. Craniofac. Surg.
30
1064-1067
2019
Ananas comosus (O24641), Ananas comosus
Kumar, P.; Jha, I.; Venkatesu, P.; Bahadur, I.; Ebenso, E.
A comparative study of the stability of stem bromelain based on the variation of anions of imidazolium-based ionic liquids
J. Mol. Liq.
246
178-186
2017
Ananas comosus (P14518)
-
Järvinen, M
Purification and properties of two protease inhibitors from rat skin inhibiting papain and other SH-proteases.
Acta Chem Scand B
30
933-40
1976
Bos taurus, Rattus
Baur, X; Fruhmann, G
Allergic reactions, including asthma, to the pineapple protease bromelain following occupational exposure.
Clin Allergy
9
443-50
1979
Ananas comosus, Homo sapiens, plant
Szilágyi, S; Szilágyi, E
Apparent sequence homology among leguminosae small molecular weight, cystine rich protease inhibitors and pineapple stem bromelain inhibitors.
Acta Biochim Biophys Acad Sci Hung
13
293-8
1978
Fabaceae, Ananas comosus
Hennrich, N; Hoffmann, A; Lang, H
[Suitability of the plant protease bromelain for substitution therapy in digestive disorders]
Arzneimittelforschung
15
434-7
1965
plant
Sebeková, K; Dämmrich, J; KrivosÃková, Z; Heidland, A
The effect of oral protease administration in the rat remnant kidney model.
Res Exp Med (Berl)
199
177-88
1999
Rattus
Paczek, L; Gaciong, Z; Bartlomiejczyk, I; Sebekova, K; Birkenmeier, G; Heidland, A
Protease administration decreases enhanced transforming growth factor-beta 1 content in isolated glomeruli of diabetic rats.
Drugs Exp Clin Res
27
141-9
2001
Rattus
Shahid, SK; Turakhia, NH; Kundra, M; Shanbag, P; Daftary, GV; Schiess, W
Efficacy and safety of phlogenzym--a protease formulation, in sepsis in children.
J Assoc Physicians India
50
527-31
2002
Homo sapiens
Schaefer, U; Brücker, B; Elbers, A; Neugebauer, E
The capacity of alpha2-macroglobulin to inhibit an exogenous protease is significantly increased in critically ill and septic patients.
Shock
22
16-22
2004
Homo sapiens
Ha, M; Bekhit, Ael-D; Carne, A
Effects of L- and iso-ascorbic acid on meat protein hydrolyzing activity of four commercial plant and three microbial protease preparations.
Food Chem
149
1-9
2014
plant
López-Pedrouso, M; Borrajo, P; Pateiro, M; Lorenzo, JM; Franco, D
Antioxidant activity and peptidomic analysis of porcine liver hydrolysates using alcalase, bromelain, flavourzyme and papain enzymes.
Food Res Int
137
109389
2020
Sus scrofa
Lee, KL; Albee, KL; Bernasconi, RJ; Edmunds, T
Complete amino acid sequence of ananain and a comparison with stem bromelain and other plant cysteine proteases.
Biochem J
327 ( Pt 1)
199-202
1997
Actinidia deliciosa, Ananas comosus, Carica papaya, Gallus gallus, plant
Azarkan, M; Maquoi, E; Delbrassine, F; Herman, R; M'Rabet, N; Calvo Esposito, R; Charlier, P; Kerff, F
Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity.
Sci Rep
10
19570
2020
Ananas comosus
Felton, GE
Does kinin released by pineapple stem bromelain stimulate production of prostaglandin E1-like compounds?
Hawaii Med J
36
39-47
1977
Ananas comosus
Baur, X
Studies on the specificity of human IgE-antibodies to the plant proteases papain and bromelain.
Clin Allergy
9
451-7
1979
Homo sapiens, plant, Betula, Secale cereale, Triticum aestivum
Gutfreund, AE; Taussig, SJ; Morris, AK
Effect of oral bromelain on blood pressure and heart rate of hypertensive patients.
Hawaii Med J
37
143-6
1978
Homo sapiens
Vidal, GP; Kato, T; Sasaki, M
Cleavage sites of human IgG by soluble and water-insoluble stem bromelain.
Immunochemistry
12
403-9
1975
Homo sapiens
Fukuda, M; Kondo, T; Osawa, T
Studies on the hydrazinolysis of glycoproteins. Core structures of oligosaccharides obtained from Porcine thyroglobulin and pineapple stem bromelain.
J Biochem (Tokyo)
80
1223-32
1976
Ananas comosus, Sus scrofa
Goldstein, N; Taussig, SJ; Gallup, JD; Koto, V
Bromelain as a skin cancer preventive in hairless mice.
Hawaii Med J
34
91-4
1975
Mus sp.
Hale, LP; Haynes, BF
Bromelain treatment of human T cells removes CD44, CD45RA, E2/MIC2, CD6, CD7, CD8, and Leu 8/LAM1 surface molecules and markedly enhances CD2-mediated T cell activation.
J Immunol
149
3809-16
1992
Homo sapiens
Andrew, EM; Annis, W; Kahan, M; Maini, RN
CD5 (Ly-1)-negative, conventional splenic B cells make a substantial contribution to the bromelain plaque-forming cell response in CBA and BW mice.
Immunology
69
515-8
1990
Mus sp.
Lotz-Winter, H
On the pharmacology of bromelain: an update with special regard to animal studies on dose-dependent effects.
Planta Med
56
249-53
1990
animal
Kumakura, S; Yamashita, M; Tsurufuji, S
Effect of bromelain on kaolin-induced inflammation in rats.
Eur J Pharmacol
150
295-301
1988
Rattus
White, RR; Crawley, FE; Vellini, M; Rovati, LA
Bioavailability of 125I bromelain after oral administration to rats.
Biopharm Drug Dispos
9
397-403
0
Rattus
Taussig, SJ; Batkin, S
Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update.
J Ethnopharmacol
22
191-203
0
Ananas comosus
Batkin, S; Taussig, S; Szekerczes, J
Modulation of pulmonary metastasis (Lewis lung carcinoma) by bromelain, an extract of the pineapple stem (Ananas comosus)
Cancer Invest
6
241-2
1988
Ananas comosus
Formanowski, F; Meier-Ewert, H
Isolation of the influenza C virus glycoprotein in a soluble form by bromelain digestion.
Virus Res
10
177-91
1988
influenza C virus
Taussig, SJ; Szekerczes, J; Batkin, S
Inhibition of tumour growth in vitro by bromelain, an extract of the pineapple plant (Ananas comosus).
Planta Med
538-9
1985
Ananas comosus, plant
Scocca, J; Lee, YC
The composition and structure of the carbohydrate of pineapple stem bromelain.
J Biol Chem
244
4852-63
1969
Ananas comosus
Doi, E; Otsuru, C; Matoba, T
Carboxypeptidase in commercial bromelain powder. Partial purification and some properties of pineapple carboxypeptidase.
J Biochem (Tokyo)
75
1063-71
1974
Ananas comosus
Heinicke, RM; van der Wal, L; Yokoyama, M
Effect of bromelain (Ananase) on human platelet aggregation.
Experientia
28
844-5
1972
Homo sapiens
Shigei, T; Sakuma, A; Nishiwaki, T
A study on the protective effect of bromelain, crude pineapple proteases, against adrenaline-induced pulmonary edema in rats.
Jpn Heart J
8
718-20
1967
Ananas comosus, Rattus
Katori, M; Shigei, T
Failure of kinin formation by glass powder in rat plasma after injection of bromelain.
Jpn J Pharmacol
18
277-9
1968
Rattus
Mineshiaa, S; Shigei, T
Prevention of adrenaline-induced pulmonary edema by stem bromelain in rabbits and analysis of the hemodynamic changes.
Jpn J Pharmacol
20
373-81
1970
Oryctolagus cuniculus
Rühl, F; Otto, H
[On the oral therapy of posttraumatic edema and hematomas with the plant proteolytic enzyme bromelain]
Therapiewoche
15
555-9
1965
plant
Katori, S
[Disappearance of kiningen I by stem bromelain and the significance in prevention of pulmonary edema in rats]
Arerugi
19
629-31
1970
Rattus
Smyth, RD; Moss, JN; Brennan, R; Harris, JC; Martin, GJ
Biochemical studies on the resolution of experimental inflammations in animals treated with bromelain.
Exp Med Surg
25
229-35
1967
Metazoa
Felton, GE
Fibrinolytic and antithrombotic action of bromelain may eliminate thrombosis in heart patients.
Med Hypotheses
6
1123-33
1980
Homo sapiens, Rattus
Mills, JB; Gennick, SE; Kostyo, JL
Fragments of human growth hormone produced by digestion with bromelain. Chemistry and biological properties.
Biochim Biophys Acta
742
169-74
1983
Homo sapiens
Thorson, JA; Sauder, SE; Gennick, SE; Kostyo, JL; Mills, JB
Complementation of human growth hormone (GH) peptide 1-134 with C-terminal fragments of human GH produced by digestion with bromelain.
Endocrinology
112
782-7
1983
Homo sapiens
Suzuki, K; Niho, T; Yamada, H; Yamaguchi, K; Ohnishi, H
[Experimental study of the effects of bromelain on the sputum consistency in rabbits]
Nippon Yakurigaku Zasshi
81
211-6
1983
Oryctolagus cuniculus
Oh-ishi, S
Fluid phase activation of Hageman factor (factor XII) in citrated human plasma by bromelain: an application to the indirect enzymatic assay for Hageman factor.
Thromb Res
27
619-23
1982
Homo sapiens
Cunliffe, DA; Cox, KO
An immunological analysis of the effects of bromelain on the mouse erythrocyte membrane.
Biochim Biophys Acta
646
275-82
1981
Mus musculus
Hatano, K; Kojima, M; Tanokura, M; Takahashi, K
Primary structure, sequence-specific 1H-NMR assignments and secondary structure in solution of bromelain inhibitor VI from pineapple stem.
Eur J Biochem
232
335-43
1995
Ananas comosus
Lommerse, JP; Kroon-Batenburg, LM; Kamerling, JP; Vliegenthart, JF
Conformational analysis of the xylose-containing N-glycan of pineapple stem bromelain as part of the intact glycoprotein.
Biochemistry
34
8196-206
1995
Ananas comosus, Homo sapiens
Cheng, HM
IgG antiphospholipid autoantibody in normal human sera is reactive against bromelain treated human erythrocytes.
J Rheumatol
20
400-1
1993
Homo sapiens
Hatano, K; Kojima, M; Tanokura, M; Takahashi, K
Solution structure of bromelain inhibitor IV from pineapple stem: structural similarity with Bowman-Birk trypsin/chymotrypsin inhibitor from soybean.
Biochemistry
35
5379-84
1996
Glycine max, Ananas comosus
Tanabe, S; Arai, S; Watanabe, M
Modification of wheat flour with bromelain and baking hypoallergenic bread with added ingredients.
Biosci Biotechnol Biochem
60
1269-72
1996
Triticum aestivum
Pike, RN; Bagarozzi, D; Travis, J
Immunological cross-reactivity of the major allergen from perennial ryegrass (Lolium perenne), Lol p I, and the cysteine proteinase, bromelain.
Int Arch Allergy Immunol
112
412-4
1997
Lolium perenne, Ananas comosus, Oryctolagus cuniculus
Mynott, TL; Guandalini, S; Raimondi, F; Fasano, A
Bromelain prevents secretion caused by Vibrio cholerae and Escherichia coli enterotoxins in rabbit ileum in vitro.
Gastroenterology
113
175-84
1997
Escherichia coli, Oryctolagus cuniculus, Vibrio cholerae
Castell, JV; Friedrich, G; Kuhn, CS; Poppe, GE
Intestinal absorption of undegraded proteins in men: presence of bromelain in plasma after oral intake.
Am J Physiol
273
G139-46
1997
Homo sapiens, Ananas comosus
Tanabe, S; Tesaki, S; Watanabe, M; Yanagihara, Y
[Cross-reactivity between bromelain and soluble fraction from wheat flour]
Arerugi
46
1170-3
1997
Triticum aestivum, Ananas comosus, Homo sapiens
Chandler, DS; Mynott, TL
Bromelain protects piglets from diarrhoea caused by oral challenge with K88 positive enterotoxigenic Escherichia coli.
Gut
43
196-202
1998
Escherichia coli, Ananas comosus, Suidae
Metzig, C; Grabowska, E; Eckert, K; Rehse, K; Maurer, HR
Bromelain proteases reduce human platelet aggregation in vitro, adhesion to bovine endothelial cells and thrombus formation in rat vessels in vivo.
In Vivo
13
7-12
0
Homo sapiens, Bos taurus, Rattus, Thrombus, Ananas comosus
Mynott, TL; Ladhams, A; Scarmato, P; Engwerda, CR
Bromelain, from pineapple stems, proteolytically blocks activation of extracellular regulated kinase-2 in T cells.
J Immunol
163
2568-75
1999
Ananas comosus
Eckert, K; Grabowska, E; Stange, R; Schneider, U; Eschmann, K; Maurer, HR
Effects of oral bromelain administration on the impaired immunocytotoxicity of mononuclear cells from mammary tumor patients.
Oncol Rep
6
1191-9
0
Homo sapiens, Ananas comosus
Glade, MJ; Kendra, D; Kaminski, MV
Improvement in protein utilization in nursing-home patients on tube feeding supplemented with an enzyme product derived from Aspergillus niger and bromelain.
Nutrition
17
348-50
2001
Aspergillus niger, Homo sapiens
Brakebusch, M; Wintergerst, U; Petropoulou, T; Notheis, G; Husfeld, L; Belohradsky, BH; Adam, D
Bromelain is an accelerator of phagocytosis, respiratory burst and Killing of Candida albicans by human granulocytes and monocytes.
Eur J Med Res
6
193-200
2001
Candida albicans, Homo sapiens
Engwerda, CR; Andrew, D; Murphy, M; Mynott, TL
Bromelain activates murine macrophages and natural killer cells in vitro.
Cell Immunol
210
5-10
2001
Mus musculus
Sawano, Y; Muramatsu, T; Hatano, K; Nagata, K; Tanokura, M
Characterization of genomic sequence coding for bromelain inhibitors in pineapple and expression of its recombinant isoform.
J Biol Chem
277
28222-7
2002
Ananas comosus
Manhart, N; Akomeah, R; Bergmeister, H; Spittler, A; Ploner, M; Roth, E
Administration of proteolytic enzymes bromelain and trypsin diminish the number of CD4+ cells and the interferon-gamma response in Peyer's patches and spleen in endotoxemic balb/c mice.
Cell Immunol
215
113-9
2002
Mus sp.
Hatano, K; Kojima, M; Tanokura, M; Takahashi, K
Nuclear magnetic resonance studies on the pKa values and interaction of ionizable groups in bromelain inhibitor VI from pineapple stem.
Biol Chem
384
93-104
2003
Ananas comosus
CIRELLI, MG
Treatment of inflammation and edema with bromelain. A plant proteolytic enzyme concentrate.
Del Med J
34
159-67
1962
plant
GILLER, FB
The effect of bromelain on levels of penicillin in the cerebrospinal fluid of rabbits.
Am J Pharm Sci Support Public Health
134
238-44
1962
Oryctolagus cuniculus
SAKUMA, A; NISHIWAKI, T; SHIGEI, T
PROTECTIVE EFFECT OF BROMELAIN AGAINST EPINEPHRINE PULMONARY EDEMA IN RATS.
Jpn J Pharmacol
14
479-81
1964
Rattus
Ivanova, VT; Kordiukova, LV; Manykin, AA; Burtseva, EI; Zagorskaia, IuV; Oskerko, TA; Slepushkin, AN
[The use of bromelain in obtaining the subviral particles of influenza A and B viruses]
Vopr Virusol
48
14-8
0
Viruses
Morrison, RN; Bruce Lyons, A; Nowak, BF; Hayball, JD
Assessment of snapper (Pagrus auratus) natural IgM binding to bromelain treated sheep erythrocytes.
Fish Shellfish Immunol
18
91-9
2005
Ovis aries
Hale, LP; Greer, PK; Trinh, CT; Gottfried, MR
Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease.
Clin Immunol
116
135-42
2005
Mus musculus, Ananas comosus, Homo sapiens, Mus sp., Metazoa
Barth, H; Guseo, A; Klein, R
In vitro study on the immunological effect of bromelain and trypsin on mononuclear cells from humans.
Eur J Med Res
10
325-31
2005
Homo sapiens
Wen, S; Huang, TH; Li, GQ; Yamahara, J; Roufogalis, BD; Li, Y
Bromelain improves decrease in defecation in postoperative rats: modulation of colonic gene expression of inducible nitric oxide synthase.
Life Sci
78
995-1002
2006
Ananas comosus, Homo sapiens, Rattus
Secor, ER; Carson, WF; Cloutier, MM; Guernsey, LA; Schramm, CM; Wu, CA; Thrall, RS
Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease.
Cell Immunol
237
68-75
2005
Mus musculus, Homo sapiens, Mus sp.
Hou, RC; Chen, YS; Huang, JR; Jeng, KC
Cross-Linked Bromelain Inhibits Lipopolysaccharide-Induced Cytokine Production Involving Cellular Signaling Suppression in Rats.
J Agric Food Chem
54
2193-2198
2006
Rattus
Hale, LP; Fitzhugh, DJ; Staats, HF
Oral immunogenicity of the plant proteinase bromelain.
Int Immunopharmacol
6
2038-46
2006
plant, Ananas comosus, Mus sp.
Taussig, SJ; Szekerczes, J; Batkin, S
Inhibition of Tumour Growth in vitro by Bromelain, an Extract of the Pineapple Plant (Ananas comosus).
Planta Med
51
538-9
1985
Ananas comosus, plant
Massimiliano, R; Pietro, R; Paolo, S; Sara, P; Michele, F
Role of bromelain in the treatment of patients with pityriasis lichenoides chronica.
J Dermatolog Treat
18
219-22
2007
Homo sapiens, Pityriasis
Umesh Hebbar, H; Sumana, B; Raghavarao, KS
Use of reverse micellar systems for the extraction and purification of bromelain from pineapple wastes.
Bioresour Technol
99
4896-902
2008
Ananas comosus
Huang, JR; Wu, CC; Hou, RC; Jeng, KC
Bromelain inhibits lipopolysaccharide-induced cytokine production in human THP-1 monocytes via the removal of CD14.
Immunol Invest
37
263-77
2008
Homo sapiens
Contreras, A; Paape, MJ; Miller, RH; Corrales, JC; Luengo, C; Sánchez, A
Effect of bromelain on milk yield, milk composition and mammary health in dairy goats.
Trop Anim Health Prod
2008
Capra hircus
Kordyukova, LV; Serebryakova, MV; Polyakov, VY; Ovchinnikova, TV; Smirnova, YA; Fedorova, NV; Baratova, LA
Influenza A virus M1 protein structure probed by in situ limited proteolysis with bromelain.
Protein Pept Lett
15
922-30
2008
influenza A virus
Apinunjarupong, S; Lapnirun, S; Theerakulkait, C
Preparation and some functional properties of rice bran protein concentrate at different degree of hydrolysis using bromelain and alkaline extraction.
Prep Biochem Biotechnol
39
183-93
2009
Oryza sativa
Bhui, K; Tyagi, S; Prakash, B; Shukla, Y
Pineapple bromelain induces autophagy, facilitating apoptotic response in mammary carcinoma cells.
Biofactors
2010
Ananas comosus
Aiyegbusi, AI; Olabiyi, OO; Duru, FI; Noronha, CC; Okanlawon, AO
A comparative study of the effects of bromelain and fresh pineapple juice on the early phase of healing in acute crush achilles tendon injury.
J Med Food
14
348-52
2011
Ananas comosus, Rattus, plant
Hu, W; Wang, AM; Wu, SY; Zhang, B; Liu, S; Gou, YB; Wang, JM
Debriding Effect of Bromelain on Firearm Wounds in Pigs.
J Trauma
2011
Suidae
Bhui, K; Tyagi, S; Srivastava, AK; Singh, M; Roy, P; Singh, R; Shukla, Y
Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2) /M arrest to apoptosis.
Mol Carcinog
2011
Homo sapiens, Ananas comosus
Grabowska, E; Eckert, K; Fichtner, I; Schulzeforster, K; Maurer, H
Bromelain proteases suppress growth, invasion and lung metastasis of B16F10 mouse melanoma cells.
Int J Oncol
11
243-8
1997
Malus domestica, Mus musculus, Mus sp.
Garbin, F; Harrach, T; Eckert, K; Maurer, H
Bromelain proteinase-f9 augments human lymphocyte-mediated growth-inhibition of various tumor-cells in-vitro.
Int J Oncol
5
197-203
1994
Homo sapiens
Harrach, T; Gebauer, F; Eckert, K; Kunze, R; Maurer, H
Bromelain proteinases modulate the cd44 expression on human molt-4/8 leukemia and sk-mel-28 melanoma-cells in-vitro.
Int J Oncol
5
485-8
1994
Homo sapiens
Sufian, KN; Hira, T; Nakamori, T; Furuta, H; Asano, K; Hara, H
Soybean ?-conglycinin bromelain hydrolysate stimulates cholecystokinin secretion by enteroendocrine STC-1 cells to suppress the appetite of rats under meal-feeding conditions.
Biosci Biotechnol Biochem
75
848-53
2011
Glycine max, Rattus
Ketnawa, S; Chaiwut, P; Rawdkuen, S
Extraction of bromelain from pineapple peels.
Food Sci Technol Int
2011
Ananas comosus, Gallus gallus, Bos taurus, Doryteuthis pealeii
Wang, W; Suguitan, AL; Zengel, J; Chen, Z; Jin, H
Generation of recombinant pandemic H1N1 influenza virus with the HA cleavable by bromelain and identification of the residues influencing HA bromelain cleavage.
Vaccine
30
872-8
2012
H1N1 subtype
Muntari, B; Amid, A; Mel, M; Jami, MS; Salleh, HM
Recombinant bromelain production in Escherichia coli: process optimization in shake flask culture by response surface methodology.
AMB Express
2
12
2012
Escherichia coli
Rosenberg, L; Krieger, Y; Silberstein, E; Arnon, O; Sinelnikov, IA; Bogdanov-Berezovsky, A; Singer, AJ
Selectivity of a bromelain based enzymatic debridement agent: A porcine study.
Burns
2012
Sus scrofa
Vilanova Neta, JL; da Silva Lédo, A; Lima, AA; Santana, JC; Leite, NS; Ruzene, DS; Silva, DP; de Souza, RR
Bromelain Enzyme from Pineapple: In Vitro Activity Study under Different Micropropagation Conditions.
Appl Biochem Biotechnol
2012
Ananas comosus
Secor, ER; Shah, SJ; Guernsey, LA; Schramm, CM; Thrall, RS
Bromelain limits airway inflammation in an ovalbumin-induced murine model of established asthma.
Altern Ther Health Med
18
9-17
0
Mus musculus, Ananas comosus
Foroncewicz, B; Mucha, K; Heidland, A; Ciszek, M; Imiela, J; Helle, F; P?czek, L
Modulation of serum levels of sRAGE by bromelain in patients with chronic kidney disease: a pilot study.
Pol Arch Med Wewn
122
514-6
2012
Homo sapiens
Errasti, ME; Caffini, NO; Pelzer, LE; Rotelli, AE
Anti-inflammatory Activity of Bromelia hieronymi: Comparison with Bromelain.
Planta Med
79
207-13
2013
Bromelia hieronymi, Ananas comosus, plant
Amini, A; Ehteda, A; Masoumi Moghaddam, S; Akhter, J; Pillai, K; Morris, DL
Cytotoxic effects of bromelain in human gastrointestinal carcinoma cell lines (MKN45, KATO-III, HT29-5F12, and HT29-5M21).
Onco Targets Ther
6
403-9
2013
Homo sapiens, Ananas comosus
Raimbault, AK; Zuily-Fodil, Y; Soler, A; Mora, P; Cruz de Carvalho, MH
The expression patterns of bromelain and AcCYS1 correlate with blackheart resistance in pineapple fruits submitted to postharvest chilling stress.
J Plant Physiol
170
1442-6
2013
Ananas comosus
de Lencastre Novaes, LC; de Carvalho Santos Ebinuma, V; Mazzola, PG; Júnior, AP
Polymer-based alternative method to extract bromelain from pineapple peel waste.
Biotechnol Appl Biochem
2013
Ananas comosus
Romano, B; Fasolino, I; Pagano, E; Capasso, R; Pace, S; De Rosa, G; Milic, N; Orlando, P; Izzo, AA; Borrelli, F
The chemopreventive action of bromelain, from pineapple stem (Ananas comosus L.), on colon carcinogenesis is related to antiproliferative and proapoptotic effects.
Mol Nutr Food Res
58
457-65
2014
Ananas comosus, Homo sapiens, Mus musculus
Büttner, L; Achilles, N; Böhm, M; Shah-Hosseini, K; Mösges, R
Efficacy and tolerability of bromelain in patients with chronic rhinosinusitis--a pilot study.
B-ENT
9
217-25
2013
Homo sapiens
Secor, ER; Szczepanek, SM; Castater, CA; Adami, AJ; Matson, AP; Rafti, ET; Guernsey, L; Natarajan, P; McNamara, JT; Schramm, CM; Thrall, RS; Silbart, LK
Bromelain Inhibits Allergic Sensitization and Murine Asthma via Modulation of Dendritic Cells.
Evid Based Complement Alternat Med
2013
702196
2013
Mus musculus, Ananas comosus
Bhatnagar, P; Pant, AB; Shukla, Y; Chaudhari, B; Kumar, P; Gupta, KC
Bromelain nanoparticles protect against 7,12-dimethylbenz[a]anthracene induced skin carcinogenesis in mouse model.
Eur J Pharm Biopharm
2015
Mus musculus
Spir, LG; Ataide, JA; De Lencastre Novaes, LC; Moriel, P; Mazzola, PG; De Borba Gurpilhares, D; Silveira, E; Pessoa, A; Tambourgi, EB
Application of an aqueous two-phase micellar system to extract bromelain from pineapple (Ananas comosus) peel waste and analysis of bromelain stability in cosmetic formulations.
Biotechnol Prog
31
937-45
0
Ananas comosus
Choi, WM; Lam, CL; Mo, WY; Wong, MH
Upgrading food wastes by means of bromelain and papain to enhance growth and immunity of grass carp (Ctenopharyngodon idella).
Environ Sci Pollut Res Int
2015
Chondrichthyes, Ctenopharyngodon idella
Croisfelt, F; Martins, BC; Rescolino, R; Coelho, DF; Zanchetta, B; Mazzola, PG; Goulart, LR; Pessoa, A; Tambourgi, EB; Silveira, E
Poly(N-Isopropylacrylamide)-co-Acrylamide Hydrogels for the Controlled Release of Bromelain from Agroindustrial Residues of Ananas comosus.
Planta Med
81
1719-26
2015
Ananas comosus
Amini, A; Masoumi-Moghaddam, S; Ehteda, A; Liauw, W; Morris, DL
Depletion of mucin in mucin-producing human gastrointestinal carcinoma: Results from in vitro and in vivo studies with bromelain and N-acetylcysteine.
Oncotarget
6
33329-44
2015
Homo sapiens, Mus musculus
Abbasi Habashi, S; Sabouni, F; Moghimi, A; Ansari Majd, S
Modulation of Lipopolysaccharide Stimulated Nuclear Factor kappa B Mediated iNOS/NO Production by Bromelain in Rat Primary Microglial Cells.
Iran Biomed J
20
33-40
2016
Rattus
dos Anjos, MM; da Silva, AA; de Pascoli, IC; Mikcha, JM; Machinski, M; Peralta, RM; de Abreu Filho, BA
Antibacterial activity of papain and bromelain on Alicyclobacillus spp.
Int J Food Microbiol
216
121-6
2016
Alicyclobacillus, Alicyclobacillus acidoterrestris, Ananas comosus, Bacteria, Citrus
Wan, J; Guo, J; Miao, Z; Guo, X
Reverse micellar extraction of bromelain from pineapple peel--Effect of surfactant structure.
Food Chem
197
450-6
2016
Ananas comosus
Errasti, ME; Prospitti, A; Viana, CA; Gonzalez, MM; Ramos, MV; Rotelli, AE; Caffini, NO
Effects on fibrinogen, fibrin, and blood coagulation of proteolytic extracts from fruits of Pseudananas macrodontes, Bromelia balansae, and B. hieronymi (Bromeliaceae) in comparison with bromelain.
Blood Coagul Fibrinolysis
2016
Ananas macrodontes, Bromelia balansae, Blumenbachia hieronymi
Müller, A; Barat, S; Chen, X; Bui, KC; Bozko, P; Malek, NP; Plentz, RR
Comparative study of antitumor effects of bromelain and papain in human cholangiocarcinoma cell lines.
Int J Oncol
48
2025-34
2016
Ananas comosus, Carica papaya, Homo sapiens, plant
Ho, D; Jagdeo, J; Waldorf, HA
Is There a Role for Arnica and Bromelain in Prevention of Post-Procedure Ecchymosis or Edema? A Systematic Review of the Literature.
Dermatol Surg
42
445-63
2016
Arnica, Homo sapiens
Agarwal, S; Chaudhary, B; Bist, R
Bacoside A and bromelain relieve dichlorvos induced changes in oxidative responses in mice serum.
Chem Biol Interact
254
173-8
2016
Mus sp., Felis catus
Cai, T; Tiscione, D; Gallelli, L; Verze, P; Palmieri, A; Mirone, V; Bartoletti, R; Malossini, G
Serenoa repens associated with selenium and lycopene extract and bromelain and methylsulfonylmethane extract are able to improve the efficacy of levofloxacin in chronic bacterial prostatitis patients.
Arch Ital Urol Androl
88
177-182
2016
Serenoa repens, Homo sapiens
Luniak, N; Meiser, P; Burkart, S; Müller, R
Heterologous expression of the plant cysteine protease bromelain and its inhibitor in Pichia pastoris.
Biotechnol Prog
33
54-65
2017
Komagataella pastoris, plant
Agarwal, S; Chaudhary, B; Bist, R
Protective propensity of bacoside A and bromelain on renal cholinesterases, ?-Aminobutyric acid and serotonin level of Mus musculus intoxicated with dichlorvos.
Chem Biol Interact
261
139-144
2017
Mus musculus, Mus sp.
Chaudhary, B; Bist, R
Protective manifestation of bacoside A and bromelain in terms of cholinesterases, gamma-amino butyric acid, serotonin level and stress proteins in the brain of dichlorvos-intoxicated mice.
Cell Stress Chaperones
22
371-376
2017
Mus sp.
Tadikonda, A; Pentapati, KC; Urala, AS; Acharya, S
Anti-plaque and anti-gingivitis effect of Papain, Bromelain, Miswak and Neem containing dentifrice: A randomized controlled trial.
J Clin Exp Dent
9
e649-e653
2017
Azadirachta indica, Homo sapiens
Passali, D; Bellussi, LM; Sarafoleanu, C; Loglisci, M; Manea, C; Iosif, C; Passali, FM
Penetration of Bromelain in Serum and Rhinosinusal Mucosa in Patients Undergoing Endoscopic Sinus Surgery.
J Pharmacol Pharmacother
8
128-129
0
Homo sapiens
Auwal, SM; Zarei, M; Abdul-Hamid, A; Saari, N
Response Surface Optimisation for the Production of Antioxidant Hydrolysates from Stone Fish Protein Using Bromelain.
Evid Based Complement Alternat Med
2017
4765463
2017
Chondrichthyes
Sancesario, GM; Nuccetelli, M; Cerri, A; Zegeer, J; Severini, C; Ciotti, MT; Pieri, M; Martorana, A; Caltagirone, C; Nistico, R; Bernardini, S
Bromelain degrades A?1-42 monomers and soluble aggregates: an in vitro study in cerebrospinal fluid of Alzheimer's disease patients.
Curr Alzheimer Res
2018
Homo sapiens
Tan, Y; Li, P
Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor.
Oncol Lett
15
2962-2966
2018
Homo sapiens
Bhamore, JR; Jha, S; Basu, H; Singhal, RK; Murthy, ZVP; Kailasa, SK
Tuning of gold nanoclusters sensing applications with bovine serum albumin and bromelain for detection of Hg
Anal Bioanal Chem
2018
Bos taurus
Singer, AJ; Toussaint, J; Chung, WT; McClain, SA; Clark, RAF; Asculai, E; Geblinger, D; Rosenberg, L
Development of a contaminated ischemic porcine wound model and the evaluation of bromelain based enzymatic debridement.
Burns
44
896-904
2018
Sus scrofa
Feng, X; Hang, S; Zhou, Y; Liu, Q; Yang, H
Bromelain Kinetics and Mechanism on Myofibril from Golden Pomfret (Trachinotus blochii).
J Food Sci
83
2148-2158
2018
Taractes rubescens, Ananas comosus
Hatano, KI; Takahashi, K; Tanokura, M
Bromein, a Bromelain Inhibitor from the Pineapple Stem: Structural and Functional Characteristics.
Protein Pept Lett
2018
Ananas comosus
Nor, MZM; Ramchandran, L; Duke, M; Vasiljevic, T
Performance of a Two-Stage Membrane System for Bromelain Separation from Pineapple Waste Mixture as Impacted by Enzymatic Pretreatment and Diafiltration.
Food Technol Biotechnol
56
218-227
2018
Ananas comosus
Debnath, R; Chatterjee, N; Das, S; Mishra, S; Bose, D; Banerjee, S; Das, S; Saha, KD; Ghosh, D; Maiti, D
Bromelain with peroxidase from pineapple are more potent to target leukemia growth inhibition - A comparison with only bromelain.
Toxicol In Vitro
55
24-32
2019
Ananas comosus
Nwagu, TN; Ugwuodo, CJ
Stabilizing bromelain for therapeutic applications by adsorption immobilization on spores of probiotic Bacillus.
Int J Biol Macromol
127
406-414
2019
Bacillus, Bacillus sp. (in: Bacteria)
Adu, TS; Mabandla, MV
Effects of bromelain on motor responses following intra-medial forebrain bundle 6-OHDA injection in rat model of parkinsonism.
Metab Brain Dis
2019
Rattus
Chia, SR; Tang, MSY; Chow, YH; Ooi, CW; Rambabu, K; Zhu, L; Show, PL
Recent Developments of Reverse Micellar Techniques for Lysozyme, Bovine Serum Albumin, and Bromelain Extraction.
Mol Biotechnol
61
715-724
2019
Bos taurus
Bakare, AO; Owoyele, BV
Bromelain reversed electrolyte imbalance in the chronically constricted sciatic nerve of Wistar rats.
Naunyn Schmiedebergs Arch Pharmacol
393
457-467
2020
Rattus norvegicus, Rattus
Italiano, G; Raimondo, M; Giannetti, G; Gargiulo, A
Benefits of a Food Supplement Containing Boswellia serrata and Bromelain for Improving the Quality of Life in Patients with Osteoarthritis: A Pilot Study.
J Altern Complement Med
26
123-129
2020
Homo sapiens, Boswellia serrata, Boswellia
Valle, SJ; Akhter, J; Mekkawy, AH; Lodh, S; Pillai, K; Badar, S; Glenn, D; Power, M; Liauw, W; Morris, DL
A novel treatment of bromelain and acetylcysteine (BromAc) in patients with peritoneal mucinous tumours: A phase I first in man study.
Eur J Surg Oncol
2019
Homo sapiens
de Melo Brites, M; Cerón, AA; Costa, SM; Oliveira, RC; Ferraz, HG; Catalani, LH; Costa, SA
Bromelain immobilization in cellulose triacetate nanofiber membranes from sugarcane bagasse by electrospinning technique.
Enzyme Microb Technol
132
109384
2020
Saccharum officinarum
Raeisi, F; Raeisi, E; Heidarian, E; Shahbazi-Gahroui, D; Lemoigne, Y
Bromelain Inhibitory Effect on Colony Formation: An In vitro Study on Human AGS, PC3, and MCF7 Cancer Cells.
J Med Signals Sens
9
267-273
0
Homo sapiens
Knackstedt, R; Gatherwright, J
Perioperative Homeopathic Arnica and Bromelain: Current Results and Future Directions.
Ann Plast Surg
84
e10-e15
2020
Arnica
Hidayat, M; Prahastuti, S; Riany, DU; Soemardji, AA; Suliska, N; Garmana, AN; Assiddiq, BF; Hasan, K
Kidney therapeutic potential of peptides derived from the bromelain hydrolysis of green peas protein.
Iran J Basic Med Sci
22
1016-1025
2019
Pisum sativum, Rattus
Bakare, AO; Owoyele, BV
Antinociceptive and neuroprotective effects of bromelain in chronic constriction injury-induced neuropathic pain in Wistar rats.
Korean J Pain
33
13-22
2020
Rattus norvegicus, Rattus
Shin, H; Kim, HT; Choi, MJ; Ko, EY
Effects of Bromelain and Double Emulsion on the Physicochemical Properties of Pork Loin.
Food Sci Anim Resour
39
888-902
2019
Sus scrofa
Selamassakul, O; Laohakunjit, N; Kerdchoechuen, O; Yang, L; Maier, CS
Bioactive peptides from brown rice protein hydrolyzed by bromelain: Relationship between biofunctional activities and flavor characteristics.
J Food Sci
85
707-717
2020
Oryza sativa
Ang, SS; Ismail-Fitry, MR
Production of Different Mushroom Protein Hydrolysates as Potential Flavourings in Chicken Soup Using Stem Bromelain Hydrolysis.
Food Technol Biotechnol
57
472-480
2019
Gallus gallus
Saptarini, NM; Rahayu, D; Herawati, IE
Antioxidant Activity of Crude Bromelain of Pineapple (Ananas comosus (L.) Merr) Crown from Subang District, Indonesia.
J Pharm Bioallied Sci
11
S551-S555
2019
Ananas comosus
Wasso, S; Maina, N; Kagira, J
Toxicity and anthelmintic efficacy of chitosan encapsulated bromelain against gastrointestinal strongyles in Small East African goats in Kenya.
Vet World
13
177-183
2020
Capra hircus, Strongyloididae, Haemonchus contortus, Nematodes
Michelini, S; Fiorentino, A; Cardone, M
Melilotus, Rutin and Bromelain in primary and secondary lymphedema.
Lymphology
52
177-186
2019
Melilotus
Jun-Hui, X; Hui-Juan, C; Bin, Z; Hui, Y
The mechanistic effect of bromelain and papain on tenderization in jumbo squid (Dosidicus gigas) muscle.
Food Res Int
131
108991
2020
Dosidicus gigas, Doryteuthis pealeii
Kiyota, K; Yoshimitsu, M; Kajimura, K; Yamano, T
[Reduction of Orange Allergen Cit s 2 Levels in Fresh Orange Juice with Pineapple Bromelain Enzymatic Treatment].
Shokuhin Eiseigaku Zasshi
61
17-21
2020
Ananas comosus
Banerjee, S; Arora, A; Vijayaraghavan, R; Patti, AF
Extraction and crosslinking of bromelain aggregates for improved stability and reusability from pineapple processing waste.
Int J Biol Macromol
158
318-326
2020
Ananas comosus
Hu, PA; Chen, CH; Guo, BC; Kou, YR; Lee, TS
Bromelain Confers Protection against the Non-Alcoholic Fatty Liver Disease in Male C57bl/6 Mice.
Nutrients
12
2020
Mus sp.
Jebur, AB; El-Demerdash, FM; Kang, W
Bromelain from Ananas comosus stem attenuates oxidative toxicity and testicular dysfunction caused by aluminum in rats.
J Trace Elem Med Biol
62
126631
2020
Ananas comosus, Rattus
Mekkawy, MH; Fahmy, HA; Nada, AS; Ali, OS
Study of the Radiosensitizing and Radioprotective Efficacy of Bromelain (a Pineapple Extract): In Vitro and In Vivo.
Integr Cancer Ther
19
1534735420950468
0
Ananas comosus
Ahmad, T; Ismail, A; Ahmad, SA; Khalil, KA; Kee, LT; Awad, EA; Sazili, AQ
Extraction, characterization and molecular structure of bovine skin gelatin extracted with plant enzymes bromelain and zingibain.
J Food Sci Technol
57
3772-3781
2020
Bos taurus, plant
Hu, R; Chen, G; Li, Y
Production and Characterization of Antioxidative Hydrolysates and Peptides from Corn Gluten Meal Using Papain, Ficin, and Bromelain.
Molecules
25
2020
Zea mays subsp. mays
Fathi, AN; Sakhaie, MH; Babaei, S; Babaei, S; Slimabad, F; Babaei, S
Use of bromelain in cutaneous wound healing in streptozocin-induced diabetic rats: an experimental model.
J Wound Care
29
488-495
2020
Rattus
Sagar, S; Rathinavel, AK; Lutz, WE; Struble, LR; Khurana, S; Schnaubelt, AT; Mishra, NK; Guda, C; Broadhurst, MJ; Reid, SPM; Bayles, KW; Borgstahl, GEO; Radhakrishnan, P
Bromelain Inhibits SARS-CoV-2 Infection in VeroE6 Cells.
bioRxiv
2020
Severe acute respiratory syndrome coronavirus 2, Ananas comosus
El-Demerdash, FM; Baghdadi, HH; Ghanem, NF; Mhanna, ABA
Nephroprotective role of bromelain against oxidative injury induced by aluminium in rats.
Environ Toxicol Pharmacol
103509
2020
Rattus
Ugwuodo, CJ; Nwagu, TNT; Ugwu, TT; Onwosi, CO
Enhancement of the Anti-inflammatory Effect of Bromelain by Its Immobilization on Probiotic Spore of Bacillus cereus.
Probiotics Antimicrob Proteins
2020
Bacillus cereus, Bacillus, Rattus, Rattus norvegicus
Kritis, P; Karampela, I; Kokoris, S; Dalamaga, M
The combination of bromelain and curcumin as an immune-boosting nutraceutical in the prevention of severe COVID-19.
Metabol Open
8
100066
2020
Severe acute respiratory syndrome coronavirus 2, Ananas comosus
Santos, DI; Fraqueza, MJ; Pissarra, H; Saraiva, JA; Vicente, AA; Moldão-Martins, M
Optimization of the Effect of Pineapple By-Products Enhanced in Bromelain by Hydrostatic Pressure on the Texture and Overall Quality of Silverside Beef Cut.
Foods
9
2020
Ananas comosus, Bos taurus, Odontesthes regia
Chandrasekaran, S; Luna-Vital, D; de Mejia, EG
Identification and Comparison of Peptides from Chickpea Protein Hydrolysates Using Either Bromelain or Gastrointestinal Enzymes and Their Relationship with Markers of Type 2 Diabetes and Bitterness.
Nutrients
12
2020
Cicer arietinum
Zhou, W; Ye, C; Geng, L; Chen, G; Wang, X; Chen, W; Sa, R; Zhang, J; Zhang, X
Purification and characterization of bromelain from pineapple (Ananas comosus L.) peel waste.
J Food Sci
86
385-393
2021
Ananas comosus
Abbas, S; Shanbhag, T; Kothare, A
Applications of bromelain from pineapple waste towards acne.
Saudi J Biol Sci
28
1001-1009
2021
Ananas comosus
Bakare, AO; Owoyele, BV
Bromelain reduced pro-inflammatory mediators as a common pathway that mediate antinociceptive and anti-anxiety effects in sciatic nerve ligated Wistar rats.
Sci Rep
11
289
2021
Rattus norvegicus, Argynnis pandora
Bist, R; Chaudhary, B; Bhatt, DK
Defensive proclivity of bacoside A and bromelain against oxidative stress and AChE gene expression induced by dichlorvos in the brain of Mus musculus.
Sci Rep
11
3668
2021
Mus musculus, Mus sp.
Sagar, S; Rathinavel, AK; Lutz, WE; Struble, LR; Khurana, S; Schnaubelt, AT; Mishra, NK; Guda, C; Palermo, NY; Broadhurst, MJ; Hoffmann, T; Bayles, KW; Reid, SPM; Borgstahl, GEO; Radhakrishnan, P
Bromelain inhibits SARS-CoV-2 infection via targeting ACE-2, TMPRSS2, and spike protein.
Clin Transl Med
11
e281
2021
Severe acute respiratory syndrome coronavirus 2
Razali, R; Budiman, C; Kamaruzaman, KA; Subbiah, VK
Soluble Expression and Catalytic Properties of Codon-Optimized Recombinant Bromelain from MD2 Pineapple in Escherichia coli.
Protein J
40
406-418
2021
Escherichia coli, Ananas comosus
Akhter, J; Quéromès, G; Pillai, K; Kepenekian, V; Badar, S; Mekkawy, AH; Frobert, E; Valle, SJ; Morris, DL
The Combination of Bromelain and Acetylcysteine (BromAc) Synergistically Inactivates SARS-CoV-2.
Viruses
13
2021
Severe acute respiratory syndrome coronavirus 2
Majumder, D; Debnath, R; Nath, P; Libin Kumar, KV; Debnath, M; Tribedi, P; Maiti, D
Bromelain and Olea europaea (L.) leaf extract mediated alleviation of benzo(a)pyrene induced lung cancer through Nrf2 and NF?B pathway.
Environ Sci Pollut Res Int
28
47306-47326
2021
Olea europaea, Ananas comosus
?ehirli, AÖ; Sayiner, S; Savtekin, G; Velio?lu-Ö?ünç, A
Protective effect of bromelain on corrosive burn in rats.
Burns
47
1352-1358
2021
Rattus
Saengsuk, N; Laohakunjit, N; Sanporkha, P; Kaisangsri, N; Selamassakul, O; Ratanakhanokchai, K; Uthairatanakij, A
Physicochemical characteristics and textural parameters of restructured pork steaks hydrolysed with bromelain.
Food Chem
361
130079
2021
Sus scrofa, Homo sapiens
Insuan, O; Janchai, P; Thongchuai, B; Chaiwongsa, R; Khamchun, S; Saoin, S; Insuan, W; Pothacharoen, P; Apiwatanapiwat, W; Boondaeng, A; Vaithanomsat, P
Anti-Inflammatory Effect of Pineapple Rhizome Bromelain through Downregulation of the NF-?B- and MAPKs-Signaling Pathways in Lipopolysaccharide (LPS)-Stimulated RAW264.7 Cells.
Curr Issues Mol Biol
43
93-106
2021
Ananas comosus
Mekkawy, AH; Pillai, K; Badar, S; Akhter, J; Ke, K; Valle, SJ; Morris, DL
Addition of bromelain and acetylcysteine to gemcitabine potentiates tumor inhibition in vivo in human colon cancer cell line LS174T.
Am J Cancer Res
11
2252-2263
2021
Homo sapiens
Hong, JH; Kim, MR; Lee, BN; Oh, WM; Min, KS; Im, YG; Hwang, YC
Anti-Inflammatory and Mineralization Effects of Bromelain on Lipopolysaccharide-Induced Inflammation of Human Dental Pulp Cells.
Medicina (Kaunas)
57
2021
Homo sapiens, Ananas comosus
Johny, LC; Kudre, TG; Suresh, PV
Production of egg white hydrolysate by digestion with pineapple bromelain: optimization, evaluation and antioxidant activity study.
J Food Sci Technol
1-12
2021
Ananas comosus
Ye, Z; Zhang, J; Lorenzo, JM; Zhang, M; Zhang, W
Effects of bromelain on the quality of smoked salted duck.
Food Sci Nutr
9
4473-4483
2021
Anas platyrhynchos
Pérez, L; Acosta, Y; Nápoles, L; Carvajal, C; Linares, C; Sershen, ; Lorenzo, JC; Pérez, A
Pineapple stem-derived bromelain based priming improves pepper seed protein reserve mobilization, germination, emergence and plant growth.
Physiol Mol Biol Plants
27
1651-1657
2021
Ananas comosus, plant
Ketnawa S;Chaiwut P;Rawdkuen S
Pineapple wastes: A potential source for bromelain extraction
Food and bioproducts processing : transactions of the Institution of Chemical Engineers, Part C.
90
385-391
2012
Ananas comosus
Hindi-Tamelikecht F;Dauphin C;Hamon M;Grangaud JP;Pradeau D
Analytic and immunologic characterization of chickpea (Cicer arietinum) protein hydrolysates obtained by bromelain and alpha-chymotrypsin.
Journal of agricultural and food chemistry
45
4758-4762
1997
Cicer arietinum
Melendo JA;Beltran JA;Roncales P
Tenderization of squid (Loligo vulgaris and Illex coindetii) with bromelain and a bovine spleen lysosomal-enriched extract.
Food research international (Ottawa, Ont.)
30
335-341
1997
Bos taurus, Doryteuthis pealeii, Illex
Benucci I;Liburdi K;Garzillo AMV;Esti M
Bromelain from pineapple stem in alcoholic-acidic buffers for wine application
Food chemistry
124
1349-1353
2011
Ananas comosus
Yin L;Sun CK;Han X;Xu L;Xu Y;Qi Y;Peng J
Preparative purification of bromelain (EC 3.4.22.33) from pineapple fruit by high-speed counter-current chromatography using a reverse-micelle solvent system
Food chemistry
129
925-932
2011
Ananas comosus
Guimarães-Ferreira, CA; Rodrigues, EG; Mortara, RA; Cabral, H; Serrano, FA; Ribeiro-dos-Santos, R; Travassos, LR
Antitumor effects in vitro and in vivo and mechanisms of protection against melanoma B16F10-Nex2 cells by fastuosain, a cysteine proteinase from Bromelia fastuosa.
Neoplasia
9
723-33
2007
Mus musculus, Mus sp.
Borrelli, F; Capasso, R; Severino, B; Fiorino, F; Aviello, G; De Rosa, G; Mazzella, M; Romano, B; Capasso, F; Fasolino, I; Izzo, AA
Inhibitory effects of bromelain, a cysteine protease derived from pineapple stem (Ananas comosus), on intestinal motility in mice.
Neurogastroenterol Motil
23
745-e331
2011
Ananas comosus, Croton, Mus musculus, Mus sp.
Owoyele, BV; Bakare, AO; Ologe, MO
Bromelain: A Review on its Potential as a Therapy for the Management of Covid-19.
Niger J Physiol Sci
35
10-19
2020
Severe acute respiratory syndrome coronavirus 2
Nishikado, H; Fujimura, T; Taka, H; Mineki, R; Ogawa, H; Okumura, K; Takai, T
Cysteine protease antigens cleave CD123, the ? subunit of murine IL-3 receptor, on basophils and suppress IL-3-mediated basophil expansion.
Biochem Biophys Res Commun
460
261-6
2015
Mus musculus
Sallai, RC; Salu, BR; Silva-Lucca, RA; Alves, FL; Napoleão, TH; Paiva, PMG; da Silva Ferreira, R; Sampaio, MU; Vilela Oliva, ML
Biotechnological Potential of Araucaria angustifolia Pine Nuts Extract and the Cysteine Protease Inhibitor AaCI-2S.
Plants (Basel)
9
2020
Callosobruchus maculatus
Nakamura, M; Inomata, M; Hayashi, M; Imahori, K; Kawashima, S
Purification and characterization of an inhibitor of calcium-activated neutral protease from rabbit skeletal muscle: purification of 50,000-dalton inhibitor.
J Biochem (Tokyo)
96
1399-407
1984
Gallus gallus, Oryctolagus cuniculus
Wolf, GB; Scherberich, JE; Fischer, P; Schoeppe, W
Isolation and characterization of dipeptidyl aminopeptidase IV from human kidney cortex.
Clin Chim Acta
179
61-71
1989
Homo sapiens
Li-Chan, EC; Hunag, SL; Jao, CL; Ho, KP; Hsu, KC
Peptides derived from atlantic salmon skin gelatin as dipeptidyl-peptidase IV inhibitors.
J Agric Food Chem
60
973-8
2012
Salmo salar
Guo, H; Richel, A; Hao, Y; Fan, X; Everaert, N; Yang, X; Ren, G
Novel dipeptidyl peptidase-IV and angiotensin-I-converting enzyme inhibitory peptides released from quinoa protein by in silico proteolysis.
Food Sci Nutr
8
1415-1422
2020
Chenopodium quinoa, plant
Acevedo-Martinez, KA; Gonzalez de Mejia, E
Fortification of Maize Tortilla with an Optimized Chickpea Hydrolysate and Its Effect on DPPIV Inhibition Capacity and Physicochemical Characteristics.
Foods
10
2021
Cicer arietinum, Zea mays
Reddy, MN; Keim, PS; Heinrikson, RL; Kezdy, FJ
Primary structural analysis of sulfhydryl protease inhibitors from pineapple stem.
J Biol Chem
250
1741-50
1975
Ananas comosus
Nishida, Y; Sumi, H; Mihara, H
A thiol protease inhibitor released from cultured human malignant melanoma cells.
Cancer Res
44
3324-9
1984
Homo sapiens
Isemura, S; Saitoh, E; Ito, S; Isemura, M; Sanada, K
Cystatin S: a cysteine proteinase inhibitor of human saliva.
J Biochem (Tokyo)
96
1311-4
1984
Bos taurus
Singh, LR; Devi, TP; Devi, SK
Purification and characterization of a pineapple crown leaf thiol protease.
Prep Biochem Biotechnol
34
25-43
2004
Ananas comosus
Oliva, ML; Carmona, AK; Andrade, SS; Cotrin, SS; Soares-Costa, A; Henrique-Silva, F
Inhibitory selectivity of canecystatin: a recombinant cysteine peptidase inhibitor from sugarcane.
Biochem Biophys Res Commun
320
1082-6
2004
plant
Andrade, S; Silva, M; Gouvea, I; Kondob, M; Julianob, M; Sampaioa, M; Olivaa, M
Baupain, a plant cysteine proteinase that hinders thrombin-induced human platelet aggregation.
Protein Pept Lett
2011
Homo sapiens
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Mus musculus, Mus sp., Rattus
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Mus musculus
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Apis mellifera, plant
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Anas platyrhynchos
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Mus musculus, plant
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Oryctolagus cuniculus
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Cucurbita pepo var. melopepo, Armoracia rusticana, Apis mellifera, Bos taurus
Wilson, IB; Harthill, JE; Mullin, NP; Ashford, DA; Altmann, F
Core alpha1,3-fucose is a key part of the epitope recognized by antibodies reacting against plant N-linked oligosaccharides and is present in a wide variety of plant extracts.
Glycobiology
8
651-61
1998
Apis mellifera, Bos taurus, Helix pomatia, Styphnolobium japonicum
Iwasaki, T; Hamano, T; Fujimoto, J; Ogata, A; Kakishita, E
Regulation of cytokine expression by an autoreactive B cell clone derived from MRL/MP-lpr/lpr mice.
Clin Exp Immunol
114
1-8
1998
Mus musculus
Sebeková, K; Dämmrich, J; Fierlbeck, W; Krivosiková, Z; Paczek, L; Heidland, A
Effect of chronic therapy with proteolytic enzymes on hypertension-induced renal injury in the rat model of Goldblatt hypertension.
Am J Nephrol
18
570-6
1998
Verum
Zeleny, R; Altmann, F; Praznik, W
Structural characterization of the N-linked oligosaccharides from tomato fruit.
Phytochemistry
51
199-210
1999
Armoracia rusticana, Ananas comosus
Afferni, C; Iacovacci, P; Barletta, B; Di Felice, G; Tinghino, R; Mari, A; Pini, C
Role of carbohydrate moieties in IgE binding to allergenic components of Cupressus arizonica pollen extract.
Clin Exp Allergy
29
1087-94
1999
Ananas comosus, Apis mellifera, Carlowrightia arizonica, Homo sapiens
Fötisch, K; Altmann, F; Haustein, D; Vieths, S
Involvement of carbohydrate epitopes in the IgE response of celery-allergic patients.
Int Arch Allergy Immunol
120
30-42
1999
Homo sapiens, Ananas comosus, Bos taurus, Apium graveolens Dulce Group, plant
Shoskes, DA; Zeitlin, SI; Shahed, A; Rajfer, J
Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial.
Urology
54
960-3
1999
Homo sapiens
Kristofiková, Z; Tejkalová, H; Klaschka, J
Amyloid beta peptide 1-40 and the function of rat hippocampal hemicholinium-3 sensitive choline carriers: effects of a proteolytic degradation in vitro.
Neurochem Res
26
203-12
2001
Rattus norvegicus, plant
Hemmer, W; Focke, M; Kolarich, D; Wilson, IB; Altmann, F; Wöhrl, S; Götz, M; Jarisch, R
Antibody binding to venom carbohydrates is a frequent cause for double positivity to honeybee and yellow jacket venom in patients with stinging-insect allergy.
J Allergy Clin Immunol
108
1045-52
2001
Brassica napus, Phleum pratense
Mynott, TL; Crossett, B; Prathalingam, SR
Proteolytic inhibition of Salmonella enterica serovar typhimurium-induced activation of the mitogen-activated protein kinases ERK and JNK in cultured human intestinal cells.
Infect Immun
70
86-95
2002
Bacteria, Salmonella enterica subsp. enterica serovar Typhimurium
Mari, A
Skin test with a timothy grass (Phleum pratense) pollen extract vs. IgE to a timothy extract vs. IgE to rPhl p 1, rPhl p 2, nPhl p 4, rPhl p 5, rPhl p 6, rPhl p 7, rPhl p 11, and rPhl p 12: epidemiological and diagnostic data.
Clin Exp Allergy
33
43-51
2003
Phleum pratense
Mari, A; Wallner, M; Ferreira, F
Fagales pollen sensitization in a birch-free area: a respiratory cohort survey using Fagales pollen extracts and birch recombinant allergens (rBet v 1, rBet v 2, rBet v 4).
Clin Exp Allergy
33
1419-28
2003
Betula, Malus domestica
Rassam, M; Laing, WA
Purification and characterization of phytocystatins from kiwifruit cortex and seeds.
Phytochemistry
65
19-30
2004
Homo sapiens
Hemmer, W; Focke, M; Kolarich, D; Dalik, I; Götz, M; Jarisch, R
Identification by immunoblot of venom glycoproteins displaying immunoglobulin E-binding N-glycans as cross-reactive allergens in honeybee and yellow jacket venom.
Clin Exp Allergy
34
460-9
2004
Brassica napus, Homo sapiens, Bos taurus
Kochuyt, AM; Van Hoeyveld, EM; Stevens, EA
Prevalence and clinical relevance of specific immunoglobulin E to pollen caused by sting- induced specific immunoglobulin E to cross-reacting carbohydrate determinants in Hymenoptera venoms.
Clin Exp Allergy
35
441-7
2005
Lolium perenne, Homo sapiens, Hepatitis B virus
Hördegen, P; Cabaret, J; Hertzberg, H; Langhans, W; Maurer, V
In vitro screening of six anthelmintic plant products against larval Haemonchus contortus with a modified methyl-thiazolyl-tetrazolium reduction assay.
J Ethnopharmacol
108
85-9
2006
plant, Ananas comosus, Azadirachta indica, Embelia ribes, Guilandina crista, Baccharoides anthelmintica, Fumaria parviflora
Jappe, U; Raulf-Heimsoth, M; Hoffmann, M; Burow, G; Hübsch-Müller, C; Enk, A
In vitro hymenoptera venom allergy diagnosis: improved by screening for cross-reactive carbohydrate determinants and reciprocal inhibition.
Allergy
61
1220-9
2006
Armoracia rusticana, Homo sapiens, Phleum pratense
Mahler, V; Gutgesell, C; Valenta, R; Fuchs, T
Natural rubber latex and hymenoptera venoms share ImmunoglobinE-epitopes accounting for cross-reactive carbohydrate determinants.
Clin Exp Allergy
36
1446-56
2006
Armoracia rusticana
Roselli, M; Britti, MS; Le Huërou-Luron, I; Marfaing, H; Zhu, WY; Mengheri, E
Effect of different plant extracts and natural substances (PENS) against membrane damage induced by enterotoxigenic Escherichia coli K88 in pig intestinal cells.
Toxicol In Vitro
21
224-9
2007
Chlorella vulgaris, Saccharomyces cerevisiae, Bos taurus
Gaby, AR
Natural remedies for scleroderma.
Altern Med Rev
11
188-95
2006
Scleroderma
Palacin, A; Quirce, S; Sánchez-Monge, R; Fernández-Nieto, M; Varela, J; Sastre, J; Salcedo, G
Allergy to kiwi in patients with baker's asthma: identification of potential cross-reactive allergens.
Ann Allergy Asthma Immunol
101
200-5
2008
Triticum aestivum
Patel, JR; Shilleto, RW
Production of virus-specific antisera to lymphoproliferative disease virus of turkeys.
Avian Pathol
16
699-705
1987
Gallus gallus, Oryctolagus cuniculus
Guilloux, L; Morisset, M; Codreanu, F; Parisot, L; Moneret-Vautrin, DA
Peanut allergy diagnosis in the context of grass pollen sensitization for 125 patients: roles of peanut and cross-reactive carbohydrate determinants specific IgE.
Int Arch Allergy Immunol
149
91-7
2009
Arachis hypogaea, Homo sapiens
Li, X; Bangari, DS; Sharma, A; Mittal, SK
Bovine adenovirus serotype 3 utilizes sialic acid as a cellular receptor for virus entry.
Virology
392
162-8
2009
Bovine adenovirus 3
Mittermann, I; Zidarn, M; Silar, M; Markovic-Housley, Z; Aberer, W; Korosec, P; Kosnik, M; Valenta, R
Recombinant allergen-based IgE testing to distinguish bee and wasp allergy.
J Allergy Clin Immunol
125
1300-1307.e3
2010
Apis mellifera
Hino, S; Umeda, F; Inumaru, S; Aoki, N; Sato, C; Okajima, T; Nadano, D; Matsuda, T
IgG2 dominancy and carbohydrate recognition specificity of C3H/He mouse antibodies directed to cross-reactive carbohydrate determinants (CCDs) bearing beta-(1,2)-xylose and alpha-(1,3)-fucose.
Immunol Lett
133
28-34
2010
Apis mellifera, Mus musculus, Mus sp., Oryctolagus cuniculus
Hale, LP; Chichlowski, M; Trinh, CT; Greer, PK
Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis.
Inflamm Bowel Dis
2010
Ananas comosus, Mus sp., Mus musculus
Leite, MS; Fujiki, TL; Silva, FV; Fileti, AM
Online intelligent controllers for an enzyme recovery plant: design methodology and performance.
Enzyme Res
2010
250843
2010
plant, Ananas comosus
Marinova, MD; Tchorbanov, BP
Preparation of antioxidant enzymatic hydrolysates from honeybee-collected pollen using plant enzymes.
Enzyme Res
2010
415949
2011
Ananas comosus
Mertens, M; Brehler, R
Suitability of Different Glycoproteins and Test Systems for Detecting Cross-Reactive Carbohydrate Determinant-Specific IgE in Hymenoptera Venom-Allergic Patients.
Int Arch Allergy Immunol
156
43-50
2011
Armoracia rusticana
Mikhailova, GR; Mazurkova, NA; Podchernyaeva, RY; Ryabchikova, EI; Troshkova, GP; Shishkina, LN
[The morphological and karyological characteristics of MDCK and vero (B) cells cultures on plant hydrolyzate-based nutrient media].
Vopr Virusol
56
9-14
0
Glycine max, Oryza sativa
Sander, I; Rozynek, P; Rihs, HP; van Kampen, V; Chew, FT; Lee, WS; Kotschy-Lang, N; Merget, R; Brüning, T; Raulf-Heimsoth, M
Multiple wheat flour allergens and cross-reactive carbohydrate determinants bind IgE in baker's asthma.
Allergy
66
1208-15
2011
Raphanus sativus, Equus caballus
Irene, D; Chen, BJ; Lo, SH; Liu, TH; Tzen, JT; Chyan, CL
Resonance assignments and secondary structure of a phytocystatin from Ananas comosus.
Biomol NMR Assign
2011
Ananas comosus
Aiyegbusi, AI; Duru, FI; Awelimobor, D; Noronha, CC; Okanlawon, AO
The role of aqueous extract of pineapple fruit parts on the healing of acute crush tendon injury.
Nig Q J Hosp Med
20
223-7
0
Ananas comosus, plant
Neis, MM; Merk, HF
Value of component based diagnostics in IgE-mediated hymenoptera sting reactions.
Cutan Ocul Toxicol
2011
Armoracia rusticana, Vespula, Apis mellifera, Homo sapiens
Eberlein, B; Krischan, L; Darsow, U; Ollert, M; Ring, J
Double positivity to bee and wasp venom: Improved diagnostic procedure by recombinant allergen-based IgE testing and basophil activation test including data about cross-reactive carbohydrate determinants.
J Allergy Clin Immunol
2012
Apis mellifera, Armoracia rusticana, Homo sapiens, bat
Mahajan, S; Chandra, V; Dave, S; Nanduri, R; Gupta, P
Stem bromelain-induced macrophage apoptosis and activation curtail Mycobacterium tuberculosis persistence.
J Infect Dis
206
366-76
2012
Ananas comosus, Homo sapiens, Mycobacterium tuberculosis
Rufino, FP; Pedroso, VM; Araujo, JN; França, AF; Rabêlo, LM; Migliolo, L; Kiyota, S; Santos, EA; Franco, OL; Oliveira, AS
Inhibitory effects of a Kunitz-type inhibitor from Pithecellobium dumosum (Benth) seeds against insect-pests' digestive proteinases.
Plant Physiol Biochem
63
70-6
2013
Carica papaya, Ananas comosus, Sus scrofa
Domingues, LF; Giglioti, R; Feitosa, KA; Fantatto, RR; Rabelo, MD; Oliveira, MC; Oliveira, GP; Chagas, AC
In vitro activity of pineapple extracts (Ananas comosus, Bromeliaceae) on Rhipicephalus (Boophilus) microplus (Acari: Ixodidae).
Exp Parasitol
2013
Ananas comosus, Microplus
Domingues, LF; Giglioti, R; Feitosa, KA; Fantatto, RR; Rabelo, MD; de Sena Oliveira, MC; Bechara, GH; de Oliveira, GP; Barioni Junior, W; de Souza Chagas, AC
In vitro and in vivo evaluation of the activity of pineapple (Ananas comosus) on Haemonchus contortus in Santa Inês sheep.
Vet Parasitol
197
263-70
2013
Ananas comosus, Haemonchus contortus, Ovis aries
Jing, X; Soto, J; Gao, Y; Phy, K; Ye, Z
Assessment of viral replication in eggs and HA protein yield of pre-pandemic H5N1 candidate vaccine viruses.
Vaccine
31
4091-7
2013
Viruses, H5N1 subtype
Luoga, W; Mansur, F; Buttle, DJ; Duce, IR; Garnett, MC; Lowe, A; Behnke, JM
The relative anthelmintic efficacy of plant-derived cysteine proteinases on intestinal nematodes.
J Helminthol
1-10
2013
Actinidia deliciosa, Carica papaya, Electron, Hemigraphis bakeri
Mansur, F; Luoga, W; Buttle, DJ; Duce, IR; Lowe, A; Behnke, JM
The anthelmintic efficacy of natural plant cysteine proteinases against two rodent cestodes Hymenolepis diminuta and Hymenolepis microstoma in vitro.
Vet Parasitol
201
48-58
2014
Hymenolepis diminuta, Rodentia, Hymenolepis microstoma, Carica papaya
Errasti, ME; Caffini, NO; Pelzer, LE; Rotelli, AE
Evaluation of anti-inflammatory activity of Pseudananas macrodontes (Morr.) Harms (Bromeliaceae) fruit extract in rats.
Z Naturforsch C
68
445-52
0
Ananas comosus
Ward, BJ; Landry, N; Trépanier, S; Mercier, G; Dargis, M; Couture, M; D'Aoust, MA; Vézina, LP
Human antibody response to N-glycans present on plant-made influenza virus-like particle (VLP) vaccines.
Vaccine
32
6098-106
2014
plant
Spitzer, F; Vahjen, W; Pieper, R; Martinez-Vallespin, B; Zentek, J
A standardised challenge model with an enterotoxigenic F4+ Escherichia coli strain in piglets assessing clinical traits and faecal shedding of fae and est-II toxin genes.
Arch Anim Nutr
68
448-59
2014
Ananas comosus, Bos taurus, Saccharomyces cerevisiae, Thymus vulgaris
Valdés-Rodríguez, S; Galván-Ramírez, JP; Guerrero-Rangel, A; Cedro-Tanda, A
Multifunctional amaranth cystatin inhibits endogenous and digestive insect cysteine endopeptidases: A potential tool to prevent proteolysis and for the control of insect pests.
Biotechnol Appl Biochem
2014
Amaranthus caudatus, Fungi
Ucuncu, Y; Celik, N; Ozturk, C; Turkoglu, M; Cetin, N; Kockara, N; Sener, E; Dundar, C; Arslan, A; Dogan, H; Kurt, N; Suleyman, H
Chondroprotective effects of a new glucosamine combination in rats: Gene expression, biochemical and histopathological evaluation.
Life Sci
130
31-7
2015
Rattus, Harpagophytum procumbens
Yang, JI; Ho, HY; Chu, YJ; Chow, CJ
Characteristic and antioxidant activity of retorted gelatin hydrolysates from cobia (Rachycentron canadum) skin.
Food Chem
110
128-36
2008
Rachycentridae
Eom, SH; Lee, SH; Chun, YG; Kim, BK; Park, DJ
Texture Softening of Beef and Chicken by Enzyme Injection Process.
Korean J Food Sci Anim Resour
35
486-93
2015
Gallus gallus, Bos taurus
Watters, CM; Burton, T; Kirui, DK; Millenbaugh, NJ
Enzymatic degradation of in vitro Staphylococcus aureus biofilms supplemented with human plasma.
Infect Drug Resist
9
71-8
2016
Staphylococcus aureus, Homo sapiens
Golezar, S
Ananas comosus Effect on Perineal Pain and Wound Healing After Episiotomy: A Randomized Double-Blind Placebo-Controlled Clinical Trial.
Iran Red Crescent Med J
18
e21019
2016
Homo sapiens
Gajanan, PG; Elavarasan, K; Shamasundar, BA
Bioactive and functional properties of protein hydrolysates from fish frame processing waste using plant proteases.
Environ Sci Pollut Res Int
23
24901-24911
2016
Chondrichthyes, plant
Oliveira, CP; Prado, WA; Lavayen, V; Büttenbender, SL; Beckenkamp, A; Martins, BS; Lüdtke, DS; Campo, LF; Rodembusch, FS; Buffon, A; Pessoa, A; Guterres, SS; Pohlmann, AR
Bromelain-Functionalized Multiple-Wall Lipid-Core Nanocapsules: Formulation, Chemical Structure and Antiproliferative Effect Against Human Breast Cancer Cells (MCF-7).
Pharm Res
34
438-452
2017
Homo sapiens
Suleria, HA; Hines, BM; Addepalli, R; Chen, W; Masci, P; Gobe, G; Osborne, SA
In vitro Anti-Thrombotic Activity of Extracts from Blacklip Abalone (Haliotis rubra) Processing Waste.
Mar Drugs
15
2016
Haliotis rubra
Mazorra-Manzano, MA; Ramírez-Suarez, JC; Yada, RY
Plant proteases for bioactive peptides release: A review.
Crit Rev Food Sci Nutr
1-17
2017
Ananas comosus, Carica papaya, plant
Suleria, HAR; Masci, PP; Addepalli, R; Chen, W; Gobe, GC; Osborne, SA
In vitro anti-thrombotic and anti-coagulant properties of blacklip abalone (Haliotis rubra) viscera hydrolysate.
Anal Bioanal Chem
409
4195-4205
2017
Haliotis rubra
Heaton, LE; Davis, JK; Rawson, ES; Nuccio, RP; Witard, OC; Stein, KW; Baar, K; Carter, JM; Baker, LB
Selected In-Season Nutritional Strategies to Enhance Recovery for Team Sport Athletes: A Practical Overview.
Sports Med
2017
Homo sapiens
Niu, L; Wu, L; Xiao, J
Inhibition of gelatinized rice starch retrogradation by rice bran protein hydrolysates.
Carbohydr Polym
175
311-319
2017
Oryza sativa
Pu, C; Tang, W
The antibacterial and antibiofilm efficacies of a liposomal peptide originating from rice bran protein against Listeria monocytogenes.
Food Funct
8
4159-4169
2017
Oryza sativa
Botinestean, C; Gomez, C; Nian, Y; Auty, MAE; Kerry, JP; Hamill, RM
Possibilities for developing texture-modified beef steaks suitable for older consumers using fruit-derived proteolytic enzymes.
J Texture Stud
2017
Bos taurus
Lin, HC; Alashi, AM; Aluko, RE; Sun Pan, B; Chang, YW
Antihypertensive properties of tilapia (
Food Nutr Res
61
1391666
2017
Rattus
Moon, SS
Effect of Proteolytic Enzymes and Ginger Extract on Tenderization of M. pectoralis profundus from Holstein Steer.
Korean J Food Sci Anim Resour
38
143-151
2018
Zingiber officinale
Passali, D; Passali, GC; Bellussi, LM; Sarafoleanu, C; Loglisci, M; Manea, C; Iosif, C; Passali, FM
Bromelain's penetration into the blood and sinonasal mucosa in patients with chronic rhinosinusitis.
Acta Otorhinolaryngol Ital
38
225-228
2018
Homo sapiens, Ananas comosus
Maqsood, S; Manheem, K; Gani, A; Abushelaibi, A
Degradation of myofibrillar, sarcoplasmic and connective tissue proteins by plant proteolytic enzymes and their impact on camel meat tenderness.
J Food Sci Technol
55
3427-3438
2018
Camelus bactrianus
Ghanbari, R; Ebrahimpour, A
Separation and identification of bromelain-generated antibacterial peptides from Actinopyga lecanora.
Food Sci Biotechnol
27
591-598
2018
Pseudomonas aeruginosa, Pseudomonas sp., Escherichia coli, Staphylococcus aureus
Cupido, GF; Gelardi, M; La Mantia, I; Aragona, SE; Ciprandi, G; ,
Broser® (bromelain, escin and selenium), oral nutraceutical, monotherapy in patients with inflammatory otorhinolaryngological disorders.
J Biol Regul Homeost Agents
33
609-615
0
Candidatus Bathyarchaeota
Selamassakul, O; Laohakunjit, N; Kerdchoechuen, O; Yang, L; Maier, CS
Isolation and characterisation of antioxidative peptides from bromelain-hydrolysed brown rice protein by proteomic technique.
Process Biochem
70
179-187
2018
Oryza sativa
Bayat, S; Amiri, N; Pishavar, E; Kalalinia, F; Movaffagh, J; Hashemi, M
Bromelain-loaded chitosan nanofibers prepared by electrospinning method for burn wound healing in animal models.
Life Sci
229
57-66
2019
animal, Ananas comosus, Rattus
Tejano, LA; Peralta, JP; Yap, EES; Chang, YW
Bioactivities of enzymatic protein hydrolysates derived from Chlorella sorokiniana.
Food Sci Nutr
7
2381-2390
2019
Chlorella sorokiniana
Mo, WY; Man, YB; Wong, MH
Soybean dreg pre-digested by enzymes can effectively replace part of the fishmeal included in feed pellets for rearing gold-lined seabream.
Sci Total Environ
704
135266
2020
Glycine max, Chondrichthyes
Mo, WY; Choi, WM; Man, KY; Wong, MH
Food waste-based pellets for feeding grass carp (Ctenopharyngodon idellus): Adding baker's yeast and enzymes to enhance growth and immunity.
Sci Total Environ
707
134954
2020
Saccharomyces cerevisiae, Ctenopharyngodon idella, plant
Naeem, H; Naqvi, SN; Perveen, R; Ishaque, F; Bano, R; Abrar, H; Arsalan, A; Malik, N
Efficiency of proteolytic enzymes in treating lumbar spine osteoarthritis (low back pain) patients and its effects on liver and kidney enzymes.
Pak J Pharm Sci
33
371-378
2020
Homo sapiens
Salehi, SH; Momeni, M; Vahdani, M; Moradi, M
Clinical Value of Debriding Enzymes as an Adjunct to Standard Early Surgical Excision in Human Burns; A Systematic Review.
J Burn Care Res
2020
Homo sapiens
Rojas, LF; Cortés, CF; Zapata, P; Jiménez, C
Extraction and identification of endopeptidases in convection dried papaya and pineapple residues: A methodological approach for application to higher scale.
Waste Manag
78
58-68
2018
Ananas comosus, Carica papaya
Gong, Q; Du, Z; Guo, J
Study on immunoregulation function of peony seed proteolysis product in mice.
J Food Biochem
e13353
2020
Mus sp.
Ajagun-Ogunleye, MO; Ebuehi, OAT
Evaluation of the anti-aging and antioxidant action of Ananas sativa and Moringa oleifera in a fruit fly model organism.
J Food Biochem
e13426
2020
Ananas comosus
Bergmann-Hug, K; Fricker, M; Hausmann, O; Helbling, A; Jörg, L
Sensitization to Hymenoptera venom in pollen allergic patients: Frequency and involvement of cross-reacting carbohydrate determinants (CCD).
PLoS One
15
e0238740
2020
Hymenoptera, Apis mellifera
Lee, KW; McKinney, BH; Blankenship, KD; Morris, DO
Detection and Inhibition of IgE for cross-reactive carbohydrate determinants evident in an enzyme-linked immunosorbent assay for detection of allergen-specific IgE in the sera of dogs and cats.
Vet Dermatol
2020
Canis lupus familiaris
Chang, CY; Jin, JD; Chang, HL; Huang, KC; Chiang, YF; Hsia, SM
Physicochemical and Antioxidative Characteristics of Potato Protein Isolate Hydrolysate.
Molecules
25
2020
Solanum tuberosum
Abram, DM; Fernandes, LGR; Perez-Riverol, A; Regina Brochetto-Braga, M; Zollner, RL
Cross-Reactive Carbohydrate Determinant in Apis mellifera, Solenopsis invicta and Polybia paulista Venoms: Identification of Allergic Sensitization and Cross-Reactivity.
Toxins (Basel)
12
2020
Apis mellifera, Solenopsis invicta, Polybia paulista, Hymenoptera, Homo sapiens
Shearer, AEH; Kniel, KE
Effect of Plant-Derived Proteases on Infectivity of Tulane Virus, Murine Norovirus, and Hepatitis A Virus.
J Food Prot
84
418-423
2021
Hepatovirus A, Murine norovirus, Tulane virus, Homo sapiens, norovirus
Sonklin, C; Alashi, AM; Laohakunjit, N; Aluko, RE
Functional Characterization of Mung Bean Meal Protein-Derived Antioxidant Peptides.
Molecules
26
2021
Vigna radiata var. radiata
Enck, KM; Lee, KW; McKinney, BH; Blankenship, KD; Montesano, C
Detection and inhibition of IgE antibodies reactive with cross-reactive carbohydrate determinants in an ELISA for allergen-specific IgE in horses.
Vet Dermatol
2021
Equidae, Fungi, Hexapoda
Santos, DI; Martins, CF; Amaral, RA; Brito, L; Saraiva, JA; Vicente, AA; Moldão-Martins, M
Pineapple (Ananas comosus L.) By-Products Valorization: Novel Bio Ingredients for Functional Foods.
Molecules
26
2021
Ananas comosus
Acevedo Martínez, KA; Gonzalezde Mejia, E
Comparison of five chickpea varieties, optimization of hydrolysates production and evaluation of biomarkers for type 2 diabetes.
Food Res Int
147
110572
2021
Cicer arietinum
Amini Chermahini, F; Raeisi, E; Aazami, MH; Mirzaei, A; Heidarian, E; Lemoigne, Y
Does Bromelain-Cisplatin Combination Afford In-Vitro Synergistic Anticancer Effects on Human Prostatic Carcinoma Cell Line, PC3?
Galen Med J
9
e1749
2020
Homo sapiens
Bowers, C; Randawa, A; Sloan, B; Anwar, U; Phipps, A; Muthayya, P
Enzymatic debridement in critically injured burn patients - Our experience in the intensive care setting and during burn resuscitation.
Burns
2021
Areas
Koh YJ;Park JI;Ahmed NU;Jung HJ;Kang KK;Hur Y;Lim YP;Nou IS
Enhancement of resistance to soft rot (Pectobacterium carotovorum subsp. carotovorum) in transgenic Brassica rapa
European journal of plant pathology
136
317-322
2013
Bacteria, Ananas comosus, Hexapoda
BHATTACHARYA R;BHATTACHARYYA D
PRESERVATION OF NATURAL STABILITY OF FRUIT "BROMELAIN" FROM ANANAS COMOSUS (PINEAPPLE)
Journal of food biochemistry
33
1-19
2009
Ananas comosus
Kleef, R; Delohery, TM; Bovbjerg, DH
Selective modulation of cell adhesion molecules on lymphocytes by bromelain protease 5.
Pathobiology
64
339-46
1996
Homo sapiens, Human immunodeficiency virus 1
Sebekova, K; Paczek, L; Dämmrich, J; Ling, H; Spustova, V; Gaciong, Z; Heidland, A
Effects of protease therapy in the remnant kidney model of progressive renal failure.
Miner Electrolyte Metab
23
291-5
1997
Rattus norvegicus
Suzuki, M; Itoh, M; Ohta, N; Nakamura, Y; Moriyama, A; Matsumoto, T; Ohashi, T; Murakami, S
Blocking of protease allergens with inhibitors reduces allergic responses in allergic rhinitis and other allergic diseases.
Acta Otolaryngol
126
746-51
2006
Mus sp.
Dutta, S; Bhattacharyya, D
Reverse Zymography Alone does not Confirm Presence of a Protease Inhibitor.
Protein J
32
155-62
2013
Catharanthus roseus, Ananas comosus
Hara, K; Iijima, K; Elias, MK; Seno, S; Tojima, I; Kobayashi, T; Kephart, GM; Kurabayashi, M; Kita, H
Airway Uric Acid Is a Sensor of Inhaled Protease Allergens and Initiates Type 2 Immune Responses in Respiratory Mucosa.
J Immunol
2014
Mus sp.
Mukherjee KD;Kiewitt I
Substrate specificity of lipases in protease preparations.
Journal of agricultural and food chemistry
46
2427-2432
1998
Carica papaya, Metazoa, Rhizopus sp.
Wright, HT
Ovalbumin is an elastase substrate.
J Biol Chem
259
14335-6
1984
Bacillus cereus
Ito, C; Yamaguchi, K; Shibutani, Y; Suzuki, K; Yamazaki, Y; Komachi, H; Ohnishi, H; Fujimura, H
[Anti-inflammatory actions of proteases, bromelain, trypsin and their mixed preparation (author's transl)]
Nippon Yakurigaku Zasshi
75
227-37
1979
Oryctolagus cuniculus
Lecomte, J
Hybridoma antibodies produced against bromelain derived cores of influenza virus.
Microbiol Immunol
29
251-63
1985
Mus musculus, Mus sp.
Vellini, M; Desideri, D; Milanese, A; Omini, C; Daffonchio, L; Hernandez, A; Brunelli, G
Possible involvement of eicosanoids in the pharmacological action of bromelain.
Arzneimittelforschung
36
110-2
1986
Rattus
Ahle, NW; Hamlet, MP
Enzymatic frostbite eschar debridement by bromelain.
Ann Emerg Med
16
1063-5
1987
Ananas comosus, Sus scrofa, plant
Kalimanovska, V; Whitaker, KB; Moss, DW
Effect of bromelain on alkaline phosphatases of intestinal and non-intestinal tissues and serum.
Clin Chim Acta
170
219-25
1987
Homo sapiens
Kottel, RH; Hanford, WC
Differential release of membrane-bound alkaline phosphatase isoenzymes from tumor cells by bromelain.
J Biochem Biophys Methods
2
325-30
1980
Homo sapiens
Lommerse, JP; Kroon-Batenburg, LM; Kroon, J; Kamerling, JP; Vliegenthart, JF
Conformations and internal mobility of a glycopeptide derived from bromelain using molecular dynamics simulations and NOESY analysis.
J Biomol NMR
6
79-94
1995
Ananas comosus
Masson, M
[Bromelain in blunt injuries of the locomotor system. A study of observed applications in general practice]
Fortschr Med
113
303-6
1995
Homo sapiens
Engwerda, CR; Andrew, D; Ladhams, A; Mynott, TL
Bromelain modulates T cell and B cell immune responses in vitro and in vivo.
Cell Immunol
210
66-75
2001
Mus sp.
Tysnes, BB; Maurer, HR; Porwol, T; Probst, B; Bjerkvig, R; Hoover, F
Bromelain reversibly inhibits invasive properties of glioma cells.
Neoplasia
3
469-79
0
Ananas comosus
Hale, LP; Greer, PK; Sempowski, GD
Bromelain treatment alters leukocyte expression of cell surface molecules involved in cellular adhesion and activation.
Clin Immunol
104
183-90
2002
Ananas comosus
Stone, MB; Merrick, MA; Ingersoll, CD; Edwards, JE
Preliminary comparison of bromelain and Ibuprofen for delayed onset muscle soreness management.
Clin J Sport Med
12
373-8
2002
Flexor
Gupta, P; Khan, RH; Saleemuddin, M
Binding of antibromelain monomeric Fab' improves the stability of stem bromelain against inactivation.
Biochim Biophys Acta
1646
131-5
2003
Oryctolagus cuniculus
Rabelo, AP; Tambourgi, EB; Pessoa, A
Bromelain partitioning in two-phase aqueous systems containing PEO-PPO-PEO block copolymers.
J Chromatogr B Analyt Technol Biomed Life Sci
807
61-8
2004
Ananas comosus
Brien, S; Lewith, G; Walker, A; Hicks, SM; Middleton, D
Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies.
Evid Based Complement Alternat Med
1
251-257
2004
Ananas comosus, plant
Gläser, D; Hilberg, T
The influence of bromelain on platelet count and platelet activity in vitro.
Platelets
17
37-41
2006
Ananas comosus, plant
Hatano, K; Sawano, Y; Miyakawa, T; Tanokura, M
Characterization of the acidic and basic limbs of a bell-shaped pH profile in the inhibitory activity of bromelain inhibitor VI.
Biopolymers
81
309-19
2006
Ananas comosus
Brien, S; Lewith, G; Walker, AF; Middleton, R; Prescott, P; Bundy, R
Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study.
QJM
99
841-50
2006
Homo sapiens
Bahde, R; Palmes, D; Minin, E; Stratmann, U; Diller, R; Haier, J; Spiegel, HU
Bromelain ameliorates hepatic microcirculation after warm ischemia.
J Surg Res
139
88-96
2007
Metazoa, Rattus
van Kampen, V; Merget, R; Brüning, T
[Occupational allergies to bromelain]
Pneumologie
61
159-61
2007
Ananas comosus
Wang, SL; Lin, HT; Liang, TW; Chen, YJ; Yen, YH; Guo, SP
Reclamation of chitinous materials by bromelain for the preparation of antitumor and antifungal materials.
Bioresour Technol
99
4386-93
2008
Doryteuthis pealeii
Onken, JE; Greer, PK; Calingaert, B; Hale, LP
Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro.
Clin Immunol
126
345-52
2008
Homo sapiens
Rookard, LE; Edmondson, O; Greenwell, P
ABO reverse grouping: effect of varying concentrations of the enzyme bromelain.
Br J Biomed Sci
66
93-7
2009
Olympus
Aiyegbusi, AI; Duru, FI; Anunobi, CC; Noronha, CC; Okanlawon, AO
Bromelain in the early phase of healing in acute crush Achilles tendon injury.
Phytother Res
2010
Ananas comosus, Rattus, Metazoa, plant
Karlsen, M; Hovden, AO; Vogelsang, P; Tysnes, BB; Appel, S
Bromelain treatment leads to maturation of monocyte-derived dendritic cells, but cannot replace PGE(2) in a cocktail of IL-1?, IL-6, TNF-? and PGE(2).
Scand J Immunol
2011
Ananas comosus, Homo sapiens
Dave, S; Kaur, NJ; Nanduri, R; Dkhar, HK; Kumar, A; Gupta, P
Inhibition of adipogenesis and induction of apoptosis and lipolysis by stem bromelain in 3T3-L1 adipocytes.
PLoS One
7
e30831
2012
Candida dubliniensis
Wu, SY; Hu, W; Zhang, B; Liu, S; Wang, JM; Wang, AM
Bromelain Ameliorates the Wound Microenvironment and Improves the Healing of Firearm Wounds.
J Surg Res
2011
Suidae, Sus scrofa
Müller, S; März, R; Schmolz, M; Drewelow, B; Eschmann, K; Meiser, P
Placebo-controlled Randomized Clinical Trial on the Immunomodulating Activities of Low- and High-Dose Bromelain after Oral Administration - New Evidence on the Antiinflammatory Mode of Action of Bromelain.
Phytother Res
2012
Homo sapiens
Coelho, DF; Silveira, E; Pessoa Junior, A; Tambourgi, EB
Bromelain purification through unconventional aqueous two-phase system (PEG/ammonium sulphate).
Bioprocess Biosyst Eng
2012
Ananas comosus
Pillai, K; Akhter, J; Chua, TC; Morris, DL
Anticancer property of bromelain with therapeutic potential in malignant peritoneal mesothelioma.
Cancer Invest
31
241-50
2013
Homo sapiens
Aichele, K; Bubel, M; Deubel, G; Pohlemann, T; Oberringer, M
Bromelain down-regulates myofibroblast differentiation in an in vitro wound healing assay.
Naunyn Schmiedebergs Arch Pharmacol
386
853-63
2013
Homo sapiens
Dayem, RN; Tameesh, MA
A new concept in hybridization: Bromelain enzyme for deproteinizing dentin before application of adhesive system.
Contemp Clin Dent
4
421-6
2013
Electron
Fouz, N; Amid, A; Hashim, YZ
Gene expression analysis in mcf-7 breast cancer cells treated with recombinant bromelain.
Appl Biochem Biotechnol
173
1618-39
2014
Homo sapiens
Ordesi, P; Pisoni, L; Nannei, P; Macchi, M; Borloni, R; Siervo, S
Therapeutic efficacy of bromelain in impacted third molar surgery: A randomized controlled clinical study.
Quintessence Int
45
679-84
2014
Ananas comosus, plant
Parodi, A; Haddix, SG; Taghipour, N; Scaria, S; Taraballi, F; Cevenini, A; Yazdi, IK; Corbo, C; Palomba, R; Khaled, SZ; Martinez, JO; Brown, BS; Isenhart, L; Tasciotti, E
Bromelain surface modification increases the diffusion of silica nanoparticles in the tumor extracellular matrix.
ACS Nano
8
9874-83
2014
Ananas comosus
Amini, A; Masoumi-Moghaddam, S; Ehteda, A; Morris, DL
Bromelain and N-acetylcysteine inhibit proliferation and survival of gastrointestinal cancer cells in vitro: significance of combination therapy.
J Exp Clin Cancer Res
33
92
2014
Homo sapiens
Kaur, H; Corscadden, K; Lott, C; Elbatarny, HS; Othman, M
Bromelain has paradoxical effects on blood coagulability: a study using thromboelastography.
Blood Coagul Fibrinolysis
2014
Ananas comosus, Mus sp., Metazoa
Mahmood, R
Purification of Anti-Bromelain Antibodies by Affinity Precipitation Using pNIPAm Linked Bromelain.
Prep Biochem Biotechnol
2015
Oryctolagus cuniculus
Agostinis, C; Zorzet, S; De Leo, R; Zauli, G; De Seta, F; Bulla, R
The combination of N-acetyl cysteine, alpha-lipoic acid, and bromelain shows high anti-inflammatory properties in novel in vivo and in vitro models of endometriosis.
Mediators Inflamm
2015
918089
2015
Mus musculus
Lourenço, CB; Ataide, JA; Cefali, LC; Celia de Lencastre Novaes, L; Moriel, P; Silveira, E; Tambourgi, EB; Mazzola, PG
Evaluation of the enzymatic activity and stability of commercial bromelain incorporated in topical formulations.
Int J Cosmet Sci
2016
Bromeliaceae, Ananas comosus, plant
Bernela, M; Ahuja, M; Thakur, R
Enhancement of anti-inflammatory activity of bromelain by its encapsulation in katira gum nanoparticles.
Carbohydr Polym
143
18-24
2016
Electron
Zaman, M; Ehtram, A; Chaturvedi, SK; Nusrat, S; Khan, RH
Amyloidogenic behavior of different intermediate state of stem bromelain: A biophysical insight.
Int J Biol Macromol
91
477-85
2016
Ananas comosus
Bhatnagar, P; Pant, AB; Shukla, Y; Panda, A; Gupta, KC
Hyaluronic acid grafted PLGA copolymer nanoparticles enhance the targeted delivery of Bromelain in Ehrlich's Ascites Carcinoma.
Eur J Pharm Biopharm
105
176-92
2016
Ananas comosus, plant
Ley, CM; Ni, Q; Liao, X; Gao, HL; Robinson, N
Bromelain and cardiovascular risk factors in diabetes: an exploratory randomized, placebo controlled, double blind clinical trial.
Chin J Integr Med
2016
Homo sapiens
Pithon, MM; Campos, MS; Coqueiro, Rda S
Effect of bromelain and papain gel on enamel deproteinisation before orthodontic bracket bonding.
Aust Orthod J
32
23-30
2016
Bos taurus
Kasemsuk, T; Saengpetch, N; Sibmooh, N; Unchern, S
Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis.
Clin Rheumatol
2016
Homo sapiens
Bormann, KH; Weber, K; Kloppenburg, H; Koch, A; Meiser, P; Gellrich, NC
Perioperative Bromelain Therapy after Wisdom Teeth Extraction - A Randomized, Placebo-Controlled, Double-Blinded, Three-Armed, Cross-Over Dose-Finding Study.
Phytother Res
2016
Homo sapiens
Rathnavelu, V; Alitheen, NB; Sohila, S; Kanagesan, S; Ramesh, R
Potential role of bromelain in clinical and therapeutic applications.
Biomed Rep
5
283-288
2016
Ananas comosus, plant
Ghensi, P; Cucchi, A; Creminelli, L; Tomasi, C; Zavan, B; Maiorana, C
Effect of Oral Administration of Bromelain on Postoperative Discomfort After Third Molar Surgery.
J Craniofac Surg
28
e191-e197
2017
Homo sapiens
Ramli, AN; Aznan, TN; Illias, RM
Bromelain: from production to commercialisation.
J Sci Food Agric
97
1386-1395
2017
Ananas comosus
Pauzi, AZ; Yeap, SK; Abu, N; Lim, KL; Omar, AR; Aziz, SA; Chow, AL; Subramani, T; Tan, SG; Alitheen, NB
Combination of cisplatin and bromelain exerts synergistic cytotoxic effects against breast cancer cell line MDA-MB-231 in vitro.
Chin Med
11
46
2016
Ananas comosus, Homo sapiens
Muhammad, ZA; Ahmad, T
Therapeutic uses of pineapple-extracted bromelain in surgical care - A review.
J Pak Med Assoc
67
121-125
2017
Ananas comosus, plant
Desideri, I; Francolini, G; Becherini, C; Terziani, F; Delli Paoli, C; Olmetto, E; Loi, M; Perna, M; Meattini, I; Scotti, V; Greto, D; Bonomo, P; Sulprizio, S; Livi, L
Use of an alpha lipoic, methylsulfonylmethane and bromelain dietary supplement (Opera(®)) for chemotherapy-induced peripheral neuropathy management, a prospective study.
Med Oncol
34
46
2017
Boswellia serrata
Singh, T; More, V; Fatima, U; Karpe, T; Aleem, MA; Prameela, J
Effect of proteolytic enzyme bromelain on pain and swelling after removal of third molars.
J Int Soc Prev Community Dent
6
S197-S204
2016
Homo sapiens
Ataide, JA; de Carvalho, NM; Rebelo, MA; Chaud, MV; Grotto, D; Gerenutti, M; Rai, M; Mazzola, PG; Jozala, AF
Bacterial Nanocellulose Loaded with Bromelain: Assessment of Antimicrobial, Antioxidant and Physical-Chemical Properties.
Sci Rep
7
18031
2017
Ananas comosus
Sonklin, C; Laohakunjit, N; Kerdchoechuen, O; Ratanakhanokchai, K
Volatile flavour compounds, sensory characteristics and antioxidant activities of mungbean meal protein hydrolysed by bromelain.
J Food Sci Technol
55
265-277
2018
Gallus gallus
Lete, I; Mendoza, N; de la Viuda, E; Carmona, F
Effectiveness of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain in the treatment of endometriosis-associated pelvic pain: LEAP study.
Eur J Obstet Gynecol Reprod Biol
228
221-224
2018
Homo sapiens
Palmisano, F; Spinelli, MG; Luzzago, S; Boeri, L; De Lorenzis, E; Albo, G; Gadda, F; Gelosa, M; Longo, F; Dell'Orto, PG; Montanari, E
Medical Expulsive Therapy for Symptomatic Distal Ureter Stones: Is the Combination of Bromelain and Tamsulosin More Effective than Tamsulosin Alone? Preliminary Results of a Single-Center Study.
Urol Int
1-8
2018
Homo sapiens
Rajan, SG; Sharma, A; Kumari, P; Biswas, S
Comparative Molecular Characterization to Reveal Surface Behaviour of Non-proteolytic Bromelain Mutants.
Curr Pharm Biotechnol
19
886-895
2018
Ananas comosus
Park, S; Oh, J; Kim, M; Jin, EJ
Bromelain effectively suppresses Kras-mutant colorectal cancer by stimulating ferroptosis.
Anim Cells Syst (Seoul)
22
334-340
2018
Homo sapiens, Mus musculus
Mendes, ML; do Nascimento-Júnior, EM; Reinheimer, DM; Martins-Filho, PR
Efficacy of proteolytic enzyme bromelain on health outcomes after third molar surgery. Systematic review and meta-analysis of randomized clinical trials.
Med Oral Patol Oral Cir Bucal
24
e61-e69
2019
Ananas comosus, Homo sapiens
Chang, TC; Wei, PL; Makondi, PT; Chen, WT; Huang, CY; Chang, YJ
Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy.
PLoS One
14
e0210274
2019
Ananas comosus, Danio rerio, Mus musculus
Han, J; Wang, L; Wang, L; Li, C; Mao, Y; Wang, Y
Fabrication of a core-shell-shell magnetic polymeric microsphere with excellent performance for separation and purification of bromelain.
Food Chem
283
1-10
2019
Ananas comosus
Soheilifar, S; Bidgoli, M; Hooshyarfard, A; Shahbazi, A; Vahdatinia, F; Khoshkhooie, F
Effect of Oral Bromelain on Wound Healing, Pain, and Bleeding at Donor Site Following Free Gingival Grafting: A Clinical Trial.
J Dent (Tehran)
15
309-316
2018
Homo sapiens
Orlandi-Mattos, PE; Aguiar, RB; da Silva Vaz, I; Moraes, JZ; de Araujo Carlini, EL; Juliano, MA; Juliano, L
Enkephalin related peptides are released from jejunum wall by orally ingested bromelain.
Peptides
115
32-42
2019
Ananas comosus, Mus sp.
Liu, S; Zhao, H; Wang, Y; Zhao, H; Ma, C
Oral Bromelain for the Control of Facial Swelling, Trismus, and Pain After Mandibular Third Molar Surgery: A Systematic Review and Meta-Analysis.
J Oral Maxillofac Surg
77
1566-1574
2019
Homo sapiens
Lee, JH; Lee, JT; Park, HR; Kim, JB
The potential use of bromelain as a natural oral medicine having anticarcinogenic activities.
Food Sci Nutr
7
1656-1667
2019
Ananas comosus
Luo, P; Han, J; Li, Y; Wang, Y; Wang, L; Ni, L
Preparation of dendritic polymer-based magnetic carrier for application of bromelain separation and purification.
J Food Biochem
43
e12976
2019
Ananas comosus
Debnath, R; Majumder, D; Nath, P; Ghosh, D; Maiti, D
Bromelain plus peroxidase reduces non-Hodgkin lymphoma progression in invivo via up-regulation of antioxidant enzymes and modulating apoptotic protein expression.
Nutr Cancer
1-11
2019
Ananas comosus, Mus sp.
Han, J; Cai, Y; Wang, L; Mao, Y; Ni, L; Wang, Y
A high efficiency method combining metal chelate ionic liquid-based aqueous two-phase flotation with two-step precipitation process for bromelain purification.
Food Chem
309
125749
2020
Ananas comosus
Mohamad, NE; Abu, N; Yeap, SK; Alitheen, NB
Bromelain Enhances the Anti-tumor Effects of Cisplatin on 4T1 Breast Tumor Model In Vivo.
Integr Cancer Ther
18
1534735419880258
0
Mus sp.
Sharafeddin, F; Safari, M
Effect of Papain and Bromelain Enzymes on Shear Bond Strength of Composite to Superficial Dentin in Different Adhesive Systems.
J Contemp Dent Pract
20
1077-1081
2019
Homo sapiens
Gross, P; Seelert, H; Meiser, P; Müller, R
Characterization of bromelain indicates a molar excess of inhibitor vs. enzyme molecules, a Jacalin-like lectin and Maillard reaction products.
J Pharm Biomed Anal
181
113075
2020
Ananas comosus
Alves, EHP; Carvalho, ADS; Silva, FRP; Carvalho França, LF; Di Lenardo, D; Vasconcelos, ACCG; Nascimento, HMS; Ribeiro Lopes, VL; Oliveira, JS; Vasconcelos, DFP
Bromelain reduces the non-alcoholic fatty liver disease and periodontal damages caused by ligature-induced periodontitis.
Oral Dis
2020
Ananas, Rattus
Murthy, SS; Narsaiah, TB
Cytotoxic Effect of Bromelain on HepG2 Hepatocellular Carcinoma Cell Line.
Appl Biochem Biotechnol
193
1873-1897
2021
Bromeliaceae, Ananas comosus
Badar, S; Azarkan, M; Mekkawy, AH; Akhter, J; Pillai, K; El Mahyaoui, R; Ke, K; Cavanaugh, L; Morris, DL
Comparison of proteolytic, cytotoxic and anticoagulant properties of chromatographically fractionated bromelain to un-fractionated bromelain.
Am J Transl Res
13
4309-4321
2021
Homo sapiens
Bottega, R; Persico, I; De Seta, F; Romano, F; Di Lorenzo, G
Anti-inflammatory properties of a proprietary bromelain extract (Bromeyal™) after in vitro simulated gastrointestinal digestion.
Int J Immunopathol Pharmacol
35
20587384211034686
0
Ananas comosus, Homo sapiens
Brito, AMM; Oliveira, V; Icimoto, MY; Nantes-Cardoso, IL
Collagenase Activity of Bromelain Immobilized at Gold Nanoparticle Interfaces for Therapeutic Applications.
Pharmaceutics
13
2021
Ananas comosus, plant
Tallei, TE; Fatimawali, ; Yelnetty, A; Idroes, R; Kusumawaty, D; Emran, TB; Yesiloglu, TZ; Sippl, W; Mahmud, S; Alqahtani, T; Alqahtani, AM; Asiri, S; Rahmatullah, M; Jahan, R; Khan, MA; Celik, I
An Analysis Based on Molecular Docking and Molecular Dynamics Simulation Study of Bromelain as Anti-SARS-CoV-2 Variants.
Front Pharmacol
12
717757
2021
Homo sapiens, Severe acute respiratory syndrome coronavirus 2
Sahbaz, A; Aynioglu, O; Isik, H; Ozmen, U; Cengil, O; Gun, BD; Gungorduk, K
Bromelain: A natural proteolytic for intra-abdominal adhesion prevention.
Int J Surg
14
7-11
2015
Ananas comosus
Chaurasiya, RS; Sakhare, PZ; Bhaskar, N; Hebbar, HU
Efficacy of reverse micellar extracted fruit bromelain in meat tenderization.
J Food Sci Technol
52
3870-80
2015
Ananas comosus, Bos taurus
de Lencastre Novaes, LC; Jozala, AF; Lopes, AM; de Carvalho Santos-Ebinuma, V; Mazzola, PG; Pessoa Junior, A
Stability, purification, and applications of bromelain: A review.
Biotechnol Prog
32
5-13
2016
Ananas comosus, Areas
Han, Z; Kraiyot, S; Kittikun, AH; Zhou, W; Li, J
Fractionation and activity profiling of fruit bromelain from pineapples of Phuket variety growing in Thailand.
J Food Biochem
e13011
2019
Ananas comosus
Chakraborty, AJ; Mitra, S; Tallei, TE; Tareq, AM; Nainu, F; Cicia, D; Dhama, K; Emran, TB; Simal-Gandara, J; Capasso, R
Bromelain a Potential Bioactive Compound: A Comprehensive Overview from a Pharmacological Perspective.
Life (Basel)
11
2021
Ananas comosus
Hsieh, CH; Wang, TY; Hung, CC; Jao, CL; Hsieh, YL; Wu, SX; Hsu, KC
In silico, in vitro and in vivo analyses of dipeptidyl peptidase IV inhibitory activity and the antidiabetic effect of sodium caseinate hydrolysate.
Food Funct
7
1122-8
2016
Bos taurus
Uchida, Y; Ohishi, S; Tanaka, K; Harada, Y; Ueno, A; Katori, M; Funahashi, S; Hashimoto, T; Ueno, T; Kodama, J
Assay methods for prekallikrein and kininogens and their applications.
Adv Exp Med Biol
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173-84
1979
Rattus
Jin, C; Focke, M; Léonard, R; Jarisch, R; Altmann, F; Hemmer, W
Reassessing the role of hyaluronidase in yellow jacket venom allergy.
J Allergy Clin Immunol
125
184-90.e1
2010
Bos taurus
Loza-Tulimowska, M; Michalak, T; Semkow, R
Attempts at detection of actomyosin associated with influenza virus.
Acta Virol
25
251-3
1981
Electron
Tretter, V; Altmann, F; März, L
Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase F cannot release glycans with fucose attached alpha 1----3 to the asparagine-linked N-acetylglucosamine residue.
Eur J Biochem
199
647-52
1991
Armoracia rusticana
Hidaka, M; Nagata, M; Kawano, Y; Sekiya, H; Kai, H; Yamasaki, K; Okumura, M; Arimori, K
Inhibitory effects of fruit juices on cytochrome P450 2C9 activity in vitro.
Biosci Biotechnol Biochem
72
406-11
2008
Ananas comosus
Yamaguchi, N; Koyama, K; Shiroeda, O; Chung, SM; Ashihara, T; Imanishi, J
Characterization of variant gamma-glutamyl transpeptidase produced by pancreatocholangiocarcinoma cell lines in a protein-free, chemically defined medium.
Pancreas
4
406-17
1989
Lens culinaris, Homo sapiens
Takami, Y; Chiba, M; Takahashi, M
Properties of gamma-glutamyl transpeptidase in squamous cell carcinoma.
J Dermatol
20
25-9
1993
Homo sapiens
Beckner, CF; Caprioli, RM
Protein N-terminal analysis using fast atom bombardment mass spectrometry.
Anal Biochem
130
328-33
1983
Bos taurus, Bacteriophage sp.
Boyle, MD; Ohanian, SH; Borsos, T
Lysis of tumor cells by antibody and complement. VI. Enhanced killing of enzyme-pretreated tumor cells.
J Immunol
116
661-8
1976
Clostridium perfringens
Turk, B; Turk, V; Turk, D
Structural and functional aspects of papain-like cysteine proteinases and their protein inhibitors.
Biol Chem
378
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plant
Zhou, S; Tannery, NH; Yang, J; Puszkin, S; Lafer, EM
The synapse-specific phosphoprotein F1-20 is identical to the clathrin assembly protein AP-3.
J Biol Chem
268
12655-62
1993
Bos taurus, Mus musculus
Rose, B; Herder, C; Löffler, H; Meierhoff, G; Schloot, NC; Walz, M; Martin, S
Dose-dependent induction of IL-6 by plant-derived proteases in vitro.
Clin Exp Immunol
143
85-92
2006
Homo sapiens
Burghoff, S; Willberg, W; Schrader, J
Identification of extracellularly phosphorylated membrane proteins.
Proteomics
15
3310-4
2015
Homo sapiens
Cheng, Y; Jiang, X; Xue, Y; Qi, F; Dai, Z; Guan, D; Kong, L
Effect of three different proteases on horsemeat tenderness during postmortem aging.
J Food Sci Technol
58
2528-2537
2021
Equus caballus
Yazawa, K; Numata, K
Papain-Catalyzed Synthesis of Polyglutamate Containing a Nylon Monomer Unit.
Polymers (Basel)
8
2016
Moesziomyces antarcticus
Jeffrey, IJ; Mosley, SM; Jones, CJ; Stoddart, RW
Proteolysis and lectin histochemistry.
Histochem J
19
269-75
1987
Mus musculus
Vogel, R; Assfalg-Machleidt, I; Esterl, A; Machleidt, W; Müller-Esterl, W
Proteinase-sensitive regions in the heavy chain of low molecular weight kininogen map to the inter-domain junctions.
J Biol Chem
263
12661-8
1988
Homo sapiens
Visual-Shah, S; Vrain, TC; Yelle, TC; Nguyen-Quoc, B; Michaud, D
An electroblotting, two-step procedure for the detection of proteinases and the study of proteinase/inhibitor complexes in gelatin-containing polyacrylamide gels.
Electrophoresis
22
2646-52
2001
Bos taurus, Sus scrofa
Goldman, SS
Evidence that the gluconeogenic pathway is confined to an enriched Müller cell fraction derived from the amphibian retina.
Exp Eye Res
50
213-8
1990
Lithobates catesbeianus
Szewczuk, A; Milnerowicz, H; Sobiech, KA
Antigenic and immunogenic properties of gamma-glutamyl-transferase preparations.
Arch Immunol Ther Exp (Warsz)
26
565-6
1978
Bos taurus
Hayashi, M
[Pharmacological studies of Shikon and Tooki. (3) Effect of topical application of the ether extracts and Shiunko on inflammatory reactions]
Nippon Yakurigaku Zasshi
73
205-14
1977
Oryctolagus cuniculus
Cox, KO; Baddams, H; Evans, A
Studies of the antigenicity and immunogenicity of bromelain-pretreated red blood cells.
Aust J Exp Biol Med Sci
55
27-37
1977
Ovis aries, Mus musculus
Keilová, H; Tomásek, V
Naturally occurring inhibitors of intracellular proteinases.
Acta Biol Med Ger
36
1873-81
1977
Ursidae
Altmann, F
Determination of amino sugars and amino acids in glycoconjugates using precolumn derivatization with o-phthalaldehyde.
Anal Biochem
204
215-9
1992
Bos taurus
Tanaka, K; Shimotori, T; Makino, S; Aikawa, Y; Inaba, T; Yoshida, C; Takano, S
Pharmacological studies of the new antiinflammatory agent 3-formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-o ne. 1st communication: antiinflammatory, analgesic and other related properties.
Arzneimittelforschung
42
935-44
1992
Rattus, Cavia
Sunny, MC; Sharma, CP
Effect of fabrication, sterilization and mediators--blood compatibility of polyurethanes.
J Biomater Appl
6
261-73
1992
Ananas comosus
Inoue, K; Motonaga, A; Nishimura, T; Yokota, M; Miki, N; Fujisawa, H; Ueda, F; Shibata, Y; Kimura, K
Mechanism of anti-inflammatory action of etodolac.
Arzneimittelforschung
41
235-9
1991
Rattus
Iwasaki, T; Hamano, T; Murata, Y; Yamasaki, T; Nagai, K
Establishment of a bromelain-treated isologous red blood cell reactive B cell clone by somatic hybridization.
Clin Immunol Immunopathol
53
78-86
1989
Mus musculus
Nicholson, LJ
Declogging small-bore feeding tubes.
JPEN J Parenter Enteral Nutr
11
594-7
0
Sus scrofa, cranberry
Uchida, Y; Katori, M
Independent consumption of high and low molecular weight kininogens in vivo.
Adv Exp Med Biol
198 Pt A
113-8
1986
Rattus
Katori, M; Hori, Y; Uchida, Y; Tanaka, K; Harada, Y
Different modes of interaction of bradykinin with prostaglandins in pain and acute inflammation.
Adv Exp Med Biol
198 Pt B
393-8
1986
Rattus
Cusack, S; Ruigrok, RW; Krygsman, PC; Mellema, JE
Structure and composition of influenza virus. A small-angle neutron scattering study.
J Mol Biol
186
565-82
1985
influenza B virus
Cunliffe, DA; Cox, KO
IgM-autoantibodies against isologous erythrocytes also react with isologous IgG(Fc).
Nature
286
720-2
1980
Mus musculus
Minakata, K; Asano, M; Sato, T; Harada, N
Assay of alpha-cysteine proteinase inhibitor in serum or plasma.
Hoppe Seylers Z Physiol Chem
363
493-8
1982
Homo sapiens
Cox, KO; Daenke, S; Samcewicz, B
Peritoneal B cells differentiate without proliferation into autoantibody secretors under the influence of factors released by other cells.
Scand J Immunol
20
527-32
1984
Mus musculus
Fujiwara, M; Kariyone, A
Lipopolysaccharide-induced autoantibody response. II. Age-related change in plaque-forming cell response to bromelain-treated syngeneic erythrocytes.
Int Arch Allergy Appl Immunol
66
161-72
1981
Mus sp.
Levenson, SM; Gruber, DK; Gruber, C; Lent, R; Seifter, E
Chemical debridement of burns: mercaptans.
J Trauma
21
632-44
1981
Ananas comosus
Altmann, F; Schweiszer, S; Weber, C
Kinetic comparison of peptide: N-glycosidases F and A reveals several differences in substrate specificity.
Glycoconj J
12
84-93
1995
Ananas comosus, Bos taurus
Yang, H; Hutchings, A; Binns, RM
Preparation and reactivities of anti-porcine CD44 monoclonal antibodies.
Scand J Immunol
37
490-8
1993
Sus scrofa
Inoue, K; Motonaga, A; Dainaka, J; Nishimura, T; Hashii, H; Yamate, K; Ueda, F; Kimura, K
Effect of etodolac on prostaglandin E2 biosynthesis, active oxygen generation and bradykinin formation.
Prostaglandins Leukot Essent Fatty Acids
51
457-62
1994
Rattus
Skea, DL; Douglas, AR; Skehel, JJ; Barber, BH
The immunotargeting approach to adjuvant-independent immunization with influenza haemagglutinin.
Vaccine
11
994-1002
1993
Mus musculus
Batanero, E; Villalba, M; Monsalve, RI; RodrÃguez, R
Cross-reactivity between the major allergen from olive pollen and unrelated glycoproteins: evidence of an epitope in the glycan moiety of the allergen.
J Allergy Clin Immunol
97
1264-71
1996
Armoracia rusticana, Apis mellifera, Homo sapiens, Oryctolagus cuniculus
Matulis, D; Lovrien, R; Richardson, TI
Coprecipitation of proteins with matrix ligands: scaleable protein isolation.
J Mol Recognit
9
433-43
0
Arachis hypogaea, Ananas comosus
Bock, U; Kolac, C; Borchard, G; Koch, K; Fuchs, R; Streichhan, P; Lehr, CM
Transport of proteolytic enzymes across Caco-2 cell monolayers.
Pharm Res
15
1393-400
1998
Homo sapiens
Maehashi, K; Matsuzaki, M; Yamamoto, Y; Udaka, S
Isolation of peptides from an enzymatic hydrolysate of food proteins and characterization of their taste properties.
Biosci Biotechnol Biochem
63
555-9
1999
Glycine max, Katsuwonus pelamis, Gallus gallus
DÃez-Gómez, ML; Quirce, S; Cuevas, M; Sánchez-Fernández, C; Baz, G; Moradiellos, FJ; MartÃnez, A
Fruit-pollen-latex cross-reactivity: implication of profilin (Bet v 2).
Allergy
54
951-61
1999
Betula, Homo sapiens
Kuberan, B; Gunay, NS; Dordick, JS; Linhardt, RJ
Preparation and isolation of neoglycoconjugates using biotin-streptavidin complexes.
Glycoconj J
16
271-81
1999
Bos taurus
Heck, AM; DeWitt, BA; Lukes, AL
Potential interactions between alternative therapies and warfarin.
Am J Health Syst Pharm
57
1221-7; quiz 1228-30
2000
Allium cepa, Allium sativum, Angelica, Apium graveolens Dulce Group, Arnica, Capsicum, Curcuma longa, Equus caballus, Ferula assa-foetida, Ginkgo, Glycyrrhiza, Levisticum officinale, Myrrhis odorata, Petroselinum crispum, Populus, Quassia, Spiraea tomentosa, Syzygium aromaticum, Tanacetum parthenium, Trifolium pratense, Trigonella foenum-graecum, Zingiber officinale
Thornhill, SM; Kelly, AM
Natural treatment of perennial allergic rhinitis.
Altern Med Rev
5
448-54
2000
Urtica dioica
GelÅnaite, L; Luksa, V; Sudziuviene, O; Bumelis, V; Pesliakas, H
Chelated mercury as a ligand in immobilized metal ion affinity chromatography of proteins.
J Chromatogr A
904
131-43
2000
Homo sapiens
Mari, A
Multiple pollen sensitization: a molecular approach to the diagnosis.
Int Arch Allergy Immunol
125
57-65
2001
Homo sapiens
Thomson, AB; Keelan, M; Thiesen, A; Clandinin, MT; Ropeleski, M; Wild, GE
Small bowel review: normal physiology part 1.
Dig Dis Sci
46
2567-87
2001
Ananas comosus
Abebe, W
An overview of herbal supplement utilization with particular emphasis on possible interactions with dental drugs and oral manifestations.
J Dent Hyg
77
37-46
2003
Ginkgo, Ephedra, Rheum rhabarbarum, Panax ginseng, Allium sativum, Glycyrrhiza, Senna, Frangula purshiana, Zingiber officinale, Tanacetum parthenium, Piper methysticum, Angelica sinensis
Vliegenthart, JF
Intramolecular carbohydrate-protein interaction.
Adv Exp Med Biol
491
133-40
2001
Malus domestica, Homo sapiens
Wallace, JM
Nutritional and botanical modulation of the inflammatory cascade--eicosanoids, cyclooxygenases, and lipoxygenases--as an adjunct in cancer therapy.
Integr Cancer Ther
1
7-37; discussion 37
2002
Boswellia
Ebo, DG; Hagendorens, MM; Bridts, CH; De Clerck, LS; Stevens, WJ
Sensitization to cross-reactive carbohydrate determinants and the ubiquitous protein profilin: mimickers of allergy.
Clin Exp Allergy
34
137-44
2004
Betula, Malus domestica, Homo sapiens
Akhtar, NM; Naseer, R; Farooqi, AZ; Aziz, W; Nazir, M
Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee--a double-blind prospective randomized study.
Clin Rheumatol
23
410-5
2004
Homo sapiens
Maniscalco, BS; Taylor, KA
Calcification in coronary artery disease can be reversed by EDTA-tetracycline long-term chemotherapy.
Pathophysiology
11
95-101
2004
Crataegus, Calloplesiops altivelis
Malandain, H
IgE-reactive carbohydrate epitopes--classification, cross-reactivity, and clinical impact.
Allerg Immunol (Paris)
37
122-8
2005
Homo sapiens
Gupta, P; Saleemuddin, M; Khan, RH
Hydrophobic interactions are the prevalent force in bromelain:fab complex.
Biochemistry (Mosc)
71 Suppl 1
S31-7
2006
Oryctolagus cuniculus
Choe, Y; Leonetti, F; Greenbaum, DC; Lecaille, F; Bogyo, M; Brömme, D; Ellman, JA; Craik, CS
Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities.
J Biol Chem
281
12824-32
2006
Homo sapiens
Serebryakova, MV; Kordyukova, LV; Baratova, LA; Markushin, SG
Mass spectrometric sequencing and acylation character analysis of C-terminal anchoring segment from Influenza A hemagglutinin.
Eur J Mass Spectrom (Chichester, Eng)
12
51-62
2006
Viruses
Yuan, G; Wahlqvist, ML; He, G; Yang, M; Li, D
Natural products and anti-inflammatory activity.
Asia Pac J Clin Nutr
15
143-52
2006
Boswellia serrata
Ivanova, VT; Rakutina, RO; Kordiukova, LV; Manykin, AA; Fedorova, NV; Ksenofontov, AL; Slepushkin, AN
[Internal epidemic influenza virus proteins: isolation and investigation]
Vopr Virusol
51
22-6
0
Viruses
Guo, R; Canter, PH; Ernst, E
Herbal medicines for the treatment of rhinosinusitis: a systematic review.
Otolaryngol Head Neck Surg
135
496-506
2006
Homo sapiens
Malamud, A; Wilson, KT
Treatment of gastrointestinal infections.
Curr Opin Gastroenterol
16
51-5
2000
Escherichia coli
Karkos, PD; Leong, SC; Arya, AK; Papouliakos, SM; Apostolidou, MT; Issing, WJ
'Complementary ENT': a systematic review of commonly used supplements.
J Laryngol Otol
121
779-82
2007
Homo sapiens
Helms, S; Miller, A
Natural treatment of chronic rhinosinusitis.
Altern Med Rev
11
196-207
2006
Urtica dioica
Baumann, L
Botanical ingredients in cosmeceuticals.
J Drugs Dermatol
6
1084-8
2007
Arnica, Camellia sinensis, Punica granatum, Glycyrrhiza
Baumann, LS
Less-known botanical cosmeceuticals.
Dermatol Ther
20
330-42
0
Arnica, Camellia sinensis, Punica granatum, Glycyrrhiza, Tanacetum parthenium
Malandain, H; Giroux, F; Cano, Y
The influence of carbohydrate structures present in common allergen sources on specific IgE results.
Eur Ann Allergy Clin Immunol
39
216-20
2007
Armoracia rusticana
Sawano, Y; Hatano, K; Miyakawa, T; Tanokura, M
Absolute side-chain structure at position 13 is required for the inhibitory activity of bromein.
J Biol Chem
283
36338-43
2008
Ananas comosus
Roxas, M
The role of enzyme supplementation in digestive disorders.
Altern Med Rev
13
307-14
2008
Ananas comosus
Rowe, DJ; Baker, AC
Perioperative risks and benefits of herbal supplements in aesthetic surgery.
Aesthet Surg J
29
150-7
0
Ginkgo biloba, Ephedra, Echinacea
Shukor, MY; Bakar, NA; Othman, AR; Yunus, I; Shamaan, NA; Syed, MA
Development of an inhibitive enzyme assay for copper.
J Environ Biol
30
39-44
2009
Pseudomonas fluorescens, Aeromonas hydrophila, Spirillum volutans, Saccharomyces cerevisiae, Oncorhynchus mykiss, activated sludge metagenome
Wen, ZZ; Wang, YH; Yang, B; Xie, MQ; Chou, KC
Roles of L5-7 Loop in the Structure and Chaperone Function of SsHSP14.1.
Protein Pept Lett
2010
Escherichia coli
Johann, K; Eschmann, K; Meiser, P
[No clinical evidence for an enhanced bleeding tendency due to perioperative treatment with bromelain].
Sportverletz Sportschaden
25
108-13
2011
Homo sapiens
Reddy, KK; Grossman, L; Rogers, GS
Common complementary and alternative therapies with potential use in dermatologic surgery: Risks and benefits.
J Am Acad Dermatol
2011
Chlorella, Arnica, Vitis vinifera, Aloe vera, Lavandula angustifolia, Calendula, Centella asiatica, Curcuma longa, Propolis
Dhandayuthapani, S; Perez, HD; Paroulek, A; Chinnakkannu, P; Kandalam, U; Jaffe, M; Rathinavelu, A
Bromelain-Induced Apoptosis in GI-101A Breast Cancer Cells.
J Med Food
2011
Ananas comosus
Trcka, J; Schäd, SG; Scheurer, S; Conti, A; Vieths, S; Gross, G; Trautmann, A
Rice-Induced Anaphylaxis: IgE-Mediated Allergy against a 56-kDa Glycoprotein.
Int Arch Allergy Immunol
158
9-17
2011
Oryza sativa
Pillai, K; Akhter, J; Chua, TC; Morris, DL
A formulation for in situ lysis of mucin secreted in pseudomyxoma peritonei.
Int J Cancer
2013
Rattus
Yao, JW; Xiao, Y; Zuo, QL; Zhang, Y; Tao, T; Lin, CJ
Effectiveness of cysteine proteases on protein/pigment film removal.
Arch Oral Biol
58
1618-26
2013
Bos taurus
Semashko, TA; Vorotnikova, EA; Sharikova, VF; Vinokurov, KS; Smirnova, YA; Dunaevsky, YE; Belozersky, MA; Oppert, B; Elpidina, EN; Filippova, IY
Selective chromogenic and fluorogenic peptide substrates for the assay of cysteine peptidases in complex mixtures.
Anal Biochem
449
179-87
2014
plant
Conrozier, T; Mathieu, P; Bonjean, M; Marc, JF; Renevier, JL; Balblanc, JC
A complex of three natural anti-inflammatory agents provides relief of osteoarthritis pain.
Altern Ther Health Med
20 Suppl 1
32-7
2014
Curcuma longa
Bekhit, AA; Hopkins, DL; Geesink, G; Bekhit, AA; Franks, P
Exogenous proteases for meat tenderization.
Crit Rev Food Sci Nutr
54
1012-31
2014
plant
Wilcox, MD; Van Rooij, LK; Chater, PI; Pereira de Sousa, I; Pearson, JP
The effect of nanoparticle permeation on the bulk rheological properties of intestinal mucus from the small intestine.
Eur J Pharm Biopharm
2015
Ananas comosus, Sus scrofa
Yokoi, H; Yoshitake, H; Matsumoto, Y; Kawada, M; Takato, Y; Shinagawa, K; Sakurai, H; Saito, K
Involvement of cross-reactive carbohydrate determinants-specific IgE in pollen allergy testing.
Asia Pac Allergy
7
29-36
2017
Armoracia rusticana, Cryptomeria japonica, Cupressus, Dactylis glomerata
Shaikh, S; Rizvi, SMD; Shakil, S; Hussain, T; Alshammari, TM; Ahmad, W; Tabrez, S; Al-Qahtani, MH; Abuzenadah, AM
Synthesis and Characterization of Cefotaxime Conjugated Gold Nanoparticles and Their Use to Target Drug-Resistant CTX-M-Producing Bacterial Pathogens.
J Cell Biochem
118
2802-2808
2017
Escherichia coli, Klebsiella pneumoniae
Cai, T; Verze, P; La Rocca, R; Palmieri, A; Tiscione, D; Luciani, LG; Mazzoli, S; Mirone, V; Malossini, G
The Clinical Efficacy of Pollen Extract and Vitamins on Chronic Prostatitis/Chronic Pelvic Pain Syndrome Is Linked to a Decrease in the Pro-Inflammatory Cytokine Interleukin-8.
World J Mens Health
35
120-128
2017
Homo sapiens
Yadav, P; Stigall, K; Johnson, HE; Rayapati, AO; Chopra, N
Functional foods: How functional are they? A case report of supplement-induced psychosis.
Int J Psychiatry Med
51
479-485
2016
Spirulina, Citrus, Chlorella, Panax ginseng, Serenoa repens, Apis mellifera, Vitis vinifera
Perera, ALHA; Perera, BGK
Development of an Economical Method to Reduce the Extractable Latex Protein Levels in Finished Dipped Rubber Products.
Biomed Res Int
2017
9573021
2017
Carica papaya, Ananas comosus
Mohamed, SIA; Jantan, I; Haque, MA
Naturally occurring immunomodulators with antitumor activity: An insight on their mechanisms of action.
Int Immunopharmacol
50
291-304
2017
Vinca
Weinkle, S; Saco, M
Approach to the Mature Cosmetic Patient: Aging Gracefully.
J Drugs Dermatol
16
s84-s86
2017
Arnica
Griffin, AS; Cabot, P; Wallwork, B; Panizza, B
Alternative therapies for chronic rhinosinusitis: A review.
Ear Nose Throat J
97
E25-E33
2018
Echinacea, Thymus vulgaris
Gürlek, F; Ünsel, M; Ardeniz, Ö; Peker Koc, Z; Gülbahar, O; Sin, AZ; Kokuludag, A; Mete Gokmen, N
Misleading Allergens in the Diagnosis of Latex Allergy: Profilin and Cross-Reactive Carbohydrate Determinants.
Int Arch Allergy Immunol
2018
Betula, Prunus persica, Ananas comosus
Ataide, JA; Gérios, EF; Mazzola, PG; Souto, EB
Bromelain-loaded nanoparticles: A comprehensive review of the state of the art.
Adv Colloid Interface Sci
254
48-55
2018
Ananas comosus, Areas
Osinga, R; Steiger, P; Giovanoli, P; Plock, JA; Mannil, L
[Burn wound treatment through enzymatic debridement: First experience in Switzerland].
Handchir Mikrochir Plast Chir
2018
Ananas comosus, plant
Zhao, F; Zhang, D; Li, X; Dong, H
High-Pressure Homogenization Pretreatment before Enzymolysis of Soy Protein Isolate: the Effect of Pressure Level on Aggregation and Structural Conformations of the Protein.
Molecules
23
2018
Glycine max
Isola, G; Matarese, M; Ramaglia, L; Iorio-Siciliano, V; Cordasco, G; Matarese, G
Efficacy of a drug composed of herbal extracts on postoperative discomfort after surgical removal of impacted mandibular third molar: a randomized, triple-blind, controlled clinical trial.
Clin Oral Investig
2018
Homo sapiens
Pillai, K; Akhter, J; Morris, DL
Assessment of a novel mucolytic solution for dissolving mucus in pseudomyxoma peritonei: an ex vivo and in vitro study.
Pleura Peritoneum
2
111-117
2017
Homo sapiens
Parravano, M; Tedeschi, M; Manca, D; Costanzo, E; Di Renzo, A; Giorno, P; Barbano, L; Ziccardi, L; Varano, M; Parisi, V
Effects of Macuprev® Supplementation in Age-Related Macular Degeneration: A Double-Blind Randomized Morpho-Functional Study Along 6 Months of Follow-Up.
Adv Ther
36
2493-2505
2019
Ganoderma lucidum, Homo sapiens, Vaccinium myrtillus
Laliberté, F; Bloom, I; Alexander, AJ
The Critical Role of Nutrition in Facial Plastic Surgery.
Facial Plast Surg Clin North Am
27
399-404
2019
Arnica montana
Zhao, F; Liu, X; Ding, X; Dong, H; Wang, W
Effects of High-Intensity Ultrasound Pretreatment on Structure, Properties, and Enzymolysis of Soy Protein Isolate.
Molecules
24
2019
Glycine max
Ataide, JA; Gérios, EF; Cefali, LC; Fernandes, AR; Teixeira, MDC; Ferreira, NR; Tambourgi, EB; Jozala, AF; Chaud, MV; Oliveira-Nascimento, L; Mazzola, PG; Souto, EB
Effect of Polysaccharide Sources on the Physicochemical Properties of Bromelain-Chitosan Nanoparticles.
Polymers (Basel)
11
2019
shrimp
Gomez, HLR; Peralta, JP; Tejano, LA; Chang, YW
In Silico and In Vitro Assessment of Portuguese Oyster (Crassostrea angulata) Proteins as Precursor of Bioactive Peptides.
Int J Mol Sci
20
2019
Crassostrea angulata
Ribeiro, JS; de Oliveira da Rosa, WL; da Silva, AF; Piva, E; Lund, RG
Efficacy of natural, peroxide-free tooth-bleaching agents: A systematic review, meta-analysis, and technological prospecting.
Phytother Res
2019
Ipomoea batatas
Ta?k?n, A; Tarakç?o?lu, M; Ulusal, H; Örkmez, M; Tays?, S
Idarubicin-bromelain combination sensitizes cancer cells to conventional chemotherapy.
Iran J Basic Med Sci
22
1172-1178
2019
Homo sapiens
Wu, AW; Gettelfinger, JD; Ting, JY; Mort, C; Higgins, TS
Alternative therapies for sinusitis and rhinitis: a systematic review utilizing a modified Delphi method.
Int Forum Allergy Rhinol
2020
Petasites hybridus
Iwaniak, A; Minkiewicz, P; Pliszka, M; Mogut, D; Darewicz, M
Characteristics of Biopeptides Released In Silico from Collagens Using Quantitative Parameters.
Foods
9
2020
Oncorhynchus mykiss, Anas platyrhynchos, Gallus gallus, Meleagris gallopavo, Equus caballus, Sus scrofa, Bos taurus, Capra hircus, Ovis aries, Oryctolagus cuniculus, salmon
Marvulli, R; Ianieri, G; De Venuto, G; Falcicchio, M; Gallo, GA; Mennuni, C; Gallone, MF; Fiore, P; Ranieri, M; Megna, M
Electrophysiological and Clinical Improvement in Non-Invasive Treatment of Carpal Tunnel Syndrome.
Endocr Metab Immune Disord Drug Targets
2020
Homo sapiens
Li, X; Qiao, J; Li, Z; Qi, L
Dual protein ligand-modified gold nanoclusters for selective detection of serum sodium copper chlorophyllin.
Spectrochim Acta A Mol Biomol Spectrosc
243
118798
2020
Bos taurus
Griffin, AS; Cabot, P; Wallwork, B; Panizza, B
Alternative therapies for chronic rhinosinusitis: A review.
Ear Nose Throat J
145561320939415
2020
Echinacea, Thymus vulgaris
Harris, L; Darby, P
Enhanced Recovery after Abdominoplasty Using Perisurgical Nutritional Supplementation.
Plast Reconstr Surg Glob Open
8
e3314
2020
Arnica, Homo sapiens
Schwarzbold, CG; Cuevas-Suárez, CE; Pacheco, RR; Ribeiro, JS; Carreño, NLV; Lund, RG; Piva, E
In vitro efficacy of commercial and experimental proteolytic enzyme-based whitening dentifrices on enamel whitening and superficial roughness.
J Esthet Restor Dent
33
849-855
2021
Bos taurus
Mócsai, R; Kaehlig, H; Blaukopf, M; Stadlmann, J; Kosma, P; Altmann, F
The Structural Difference of Isobaric N-Glycans of Two Microalgae Samples Reveals Taxonomic Distance.
Front Plant Sci
12
643249
2021
Ananas comosus
Vojdani, A; Lerner, A; Vojdani, E
Cross-Reactivity and Sequence Homology Between Alpha-Synuclein and Food Products: A Step Further for Parkinson's Disease Synucleinopathy.
Cells
10
2021
Arachis hypogaea, Glycine max, Lens culinaris, Pisum sativum, Saccharomyces cerevisiae, shrimp, Solanum tuberosum, Triticum aestivum
Khan, R; Sharma, N; Garg, Y; Kumar, G; Garg, K; Aleemuddin, M
Comparison of Different Dentin Deproteinizing Agents on the Shear Bond Strength of Resin-bonded Dentin.
Int J Clin Pediatr Dent
13
S69-S77
2020
Ananas comosus
Rohn S;Rawel HM;Rober M;Kroll J
Reactions with phenolic substances can induce changes in some physico-chemical properties and activities of bromelain--the consequences for supplementary food products.
International journal of food science and technology.
40
771-782
2005
Ananas comosus
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