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Information on EC 3.4.21.B45 - kallikrein 14 and Organism(s) Homo sapiens
for references in articles please use BRENDA:EC3.4.21.B45preliminary BRENDA-supplied EC number
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3.4.21.B45 kallikrein 14Specify your search results
Word Map
- 3.4.21.B45
- klk5
-
stratum
-
desquamation
- corneum
- netherton
-
proteinase-activated
-
trypsin-like
-
kazal-type
- lekti
-
corneodesmosomes
- medicine
-
kazal
-
granulosum
-
endocrine-related
- spink6
- diagnostics
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
klk14, kallikrein 14, kallikrein-related peptidase 14, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
kallikrein-related peptidase 14
KLK14
S01.029
-
-
-
-
KLK14
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
342900-46-3
-
9001-01-8
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Ala-Thr-Pro-Lys-Ile-Phe-Asn + H2O
Ala-Thr-Pro-Lys + Ile-Phe-Asn
19% cleavage after 1 h incubation
-
-
?
collagen alpha1 (XII and XIX) chain precursor + H2O
?
-
residues 1838-1841
-
-
?
D-Ile-Pro-Arg-p-nitroanilide + H2O
D-Ile-Pro-Arg + p-nitroaniline
-
-
-
?
D-Val-Leu-Lys-thiobenzyl ester + H2O
D-Val-Leu-Lys + thiobenzyl alcohol
low activity
-
-
?
GDDSTPSILPAPRGYPGQV + H2O
GDDSTPSILPAPR + GYPGQV
the tethered ligand is GYPGQV
-
-
?
GPNSKGRSLIGRLDTPYGGC + H2O
SLIGRLDTPYGGC + RLDTPYGGC + GPNSKGRSLIG
the tethered ligand is SLIGRL
-
-
?
GTNRSSKGRSLIGKVDGTSHVTGKGVT + H2O
GTNRSSKGR + SLIGKVDGTSHVTGKGVT
the tethered ligand is SLIGKV
-
-
?
HAI-1A + H2O
?
HAI-1A is extensively degraded when the protease:inhibitor stoichiometry is 1:1, or the enzyme is in excess. When the inhibitor is in excess, processing of HAI-1A generates fragments that likely mediate inhibition of pro-hepatocyte growth factor convertases
-
-
?
human proteinase-activated receptor 2 zymogen + H2O
mature human proteinase-activated receptor 2 + ?
unmasking the PAR2 receptor-activating sequence from a peptide precursor
-
-
?
L-Gln-Gly-Asp-Lys-Ile-Ile-Asp + H2O
L-Gln-Gly-Asp-Lys + Ile-Ile-Asp
41% cleavage after 1 h incubation
-
-
?
L-Glu-Thr-Arg-Ile-Ile-Lys + H2O
L-Glu-Thr-Arg + Ile-Ile-Lys
55% cleavage after 1 h incubation
-
-
?
L-Ile-Gln-Ser-Arg-Ile-Val-Gly + H2O
L-Ile-Gln-Ser-Arg + Ile-Val-Gly
97% cleavage after 1 h incubation
-
-
?
L-Ile-Leu-Ser-Arg-Ile-Val-Gly + H2O
L-Ile-Leu-Ser-Arg + Ile-Val-Gly
87% cleavage after 1 h incubation
-
-
?
L-Pro-Phe-Arg-7-amido-4-methylcoumarin + H2O
L-Pro-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
L-Ser-Ser-Ser-Arg-Ile-Ile-Asn + H2O
L-Ser-Ser-Ser-Arg + Ile-Ile-Asn
57% cleavage after 1 h incubation
-
-
?
methoxy-succinyl-Arg-Pro-Tyr-p-nitroanilide + H2O
methoxy-succinyl-Arg-Pro-Tyr + p-nitroaniline
very low activity
-
-
?
NATLDPRSFLLRNPNDKYE + H2O
NATLDPR + SFLLRNPNDKYE
the tethered ligand is SFLLRN
-
-
?
pro-hepatocyte growth factor + H2O
?
the enzyme converts pro-hepatocyte growth factor to the two-chain heterodimer required for Met activation, while higher concentrations degrade the hepatocyte growth factor alpha-chain. When pro-hepatocyte growth factor is in vast excess it is activated by KLK14, and as the substrate concentration increases above a threshold level (protease:substrate ratio above 1:200), hepatocyte growth factor is inactivated
-
-
?
pro-KLK3 + H2O
KLK3 + ?
KLK3 is activated by cleavage after arginine at position 7
-
-
?
proprotein convertase subtilisin/kexin type 5 precursor + H2O
?
-
residues 371-375
-
-
?
proteinase-activated receptor 2 zymogen + H2O
mature proteinase-activated receptor 2 + ?
-
-
-
?
rat proteinase-activated receptor 2 zymogen + H2O
mature rat proteinase-activated receptor 2 + ?
unmasking the PAR2 receptor-activating sequence from a peptide precursor
-
-
?
serin protease inhibitor Kazal-type 5 precursor + H2O
?
-
residues 1034-1037
-
-
?
tosyl-Gly-L-Pro-L-Arg-4-nitroanilide + H2O
tosyl-Gly-L-Pro-L-Arg + 4-nitroaniline
-
-
-
-
?
vascular endothelial growth factor receptor 3 precursor + H2O
?
-
residues 1126-1130
-
-
?
additional information
?
-
does not cleave L-Glu-Ser-Ser-Lys-Val-Leu-Asn, L-Ser-Cys-Ser-Gln-Ile-Ile-Asn, L-Glu-Gln-Asn-Lys-Leu-Val-His, L-Gln-Glu-Asp-Lys-Val-Leu-Gly, L-Asp-Thr-Arg-Ala-Ile-Gly, L-Asn-Asp-Thr-Arg-Leu-Asp-Pro, L-Asp-Glu-Asn-Lys-Ile-Ile-Gly, and L-Asp-Gly-Asp-Lys-Leu-Leu-Glu
-
-
?
additional information
?
-
-
does not cleave L-Glu-Ser-Ser-Lys-Val-Leu-Asn, L-Ser-Cys-Ser-Gln-Ile-Ile-Asn, L-Glu-Gln-Asn-Lys-Leu-Val-His, L-Gln-Glu-Asp-Lys-Val-Leu-Gly, L-Asp-Thr-Arg-Ala-Ile-Gly, L-Asn-Asp-Thr-Arg-Leu-Asp-Pro, L-Asp-Glu-Asn-Lys-Ile-Ile-Gly, and L-Asp-Gly-Asp-Lys-Leu-Leu-Glu
-
-
?
additional information
?
-
crucial cascade-mediated function of KLK14 in regulating the coagulation and liquefaction of human semen
-
-
?
additional information
?
-
-
crucial cascade-mediated function of KLK14 in regulating the coagulation and liquefaction of human semen
-
-
?
additional information
?
-
the enzyme activates the proteinase-activated receptor 2 recombinnatly expressed in rat and in human cells
-
-
?
additional information
?
-
-
the enzyme activates the proteinase-activated receptor 2 recombinnatly expressed in rat and in human cells
-
-
?
additional information
?
-
determination of substrate and cleavage site specificities of the enzyme using peptide fused to 4-nitroanilide as substrates, molecular modeling of preferred KLK14 substrates. The enzyme KLK14 displays a preference for Tyr and Trp at the P4 site
-
-
?
additional information
?
-
KLK14 can cleave synthetic peptides representing the cleavage-activation sequences of human proteinase-activated receptors PARs 1, 2 and 4 to unmask a receptor-activating sequence. Substrate specificity, overview. Analysis of processing of synthetic human and rat proteinase-activated receptor 2, PAR2, derived sequences, representing the cleavage activation domain of PAR2, by kallikrein 8 versus kallikrein 14. KLKs 8 and 14 can both cleave the synthetic PAR2 tethered ligand-containing synthetic peptides to unmask a potential receptor-activating sequence, but each KLK exhibits distinct signalling properties via PARs 1 and 2
-
-
?
additional information
?
-
-
KLK14 can cleave synthetic peptides representing the cleavage-activation sequences of human proteinase-activated receptors PARs 1, 2 and 4 to unmask a receptor-activating sequence. Substrate specificity, overview. Analysis of processing of synthetic human and rat proteinase-activated receptor 2, PAR2, derived sequences, representing the cleavage activation domain of PAR2, by kallikrein 8 versus kallikrein 14. KLKs 8 and 14 can both cleave the synthetic PAR2 tethered ligand-containing synthetic peptides to unmask a potential receptor-activating sequence, but each KLK exhibits distinct signalling properties via PARs 1 and 2
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
collagen alpha1 (XII and XIX) chain precursor + H2O
?
-
residues 1838-1841
-
-
?
pro-hepatocyte growth factor + H2O
?
the enzyme converts pro-hepatocyte growth factor to the two-chain heterodimer required for Met activation, while higher concentrations degrade the hepatocyte growth factor alpha-chain. When pro-hepatocyte growth factor is in vast excess it is activated by KLK14, and as the substrate concentration increases above a threshold level (protease:substrate ratio above 1:200), hepatocyte growth factor is inactivated
-
-
?
proprotein convertase subtilisin/kexin type 5 precursor + H2O
?
-
residues 371-375
-
-
?
proteinase-activated receptor 2 zymogen + H2O
mature proteinase-activated receptor 2 + ?
-
-
-
?
serin protease inhibitor Kazal-type 5 precursor + H2O
?
-
residues 1034-1037
-
-
?
vascular endothelial growth factor receptor 3 precursor + H2O
?
-
residues 1126-1130
-
-
?
additional information
?
-
crucial cascade-mediated function of KLK14 in regulating the coagulation and liquefaction of human semen
-
-
?
additional information
?
-
-
crucial cascade-mediated function of KLK14 in regulating the coagulation and liquefaction of human semen
-
-
?
additional information
?
-
the enzyme activates the proteinase-activated receptor 2 recombinnatly expressed in rat and in human cells
-
-
?
additional information
?
-
-
the enzyme activates the proteinase-activated receptor 2 recombinnatly expressed in rat and in human cells
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
HAI-1A
no inhibition of KLK14 up to equimolar concentrations (5 nm) of enzyme and inhibitor. As the reaction shifts to containing excess inhibitor, KLK14 is mildly inhibited, with inhibition of 35% obtained when HAI-1A is present at 10fold excess over protease
-
HAI-1B
no inhibition of KLK14 up to equimolar concentrations (5 nm) of enzyme and inhibitor. As the reaction shifts to containing excess inhibitor, KLK14 is mildly inhibited, with inhibition of 26% obtained when HAI-1B is present at 10fold excess over protease
-
Spink6
-
i.e. serine protease inhibitor Kazal type 6. Selective inhibitor of kallikreins in the skin. Spink6 possesses only one typical Kazal domain. Its mRNA is expressed at low levels in several tissues and is induced during keratinocyte differentiation. Spink6 is expressed in the stratum granulosum of human skin at various anatomical localisations and in the skin appendages, including sebaceous glands and sweat glands. Spink6 expression is decreased in lesions of atopic dermatitis. Recombinant SPINK6 is inhibitory for KLK5, KLK7 and KLK14
-
vaspin
vaspin represents a multispecific serpin targeting the kallikrein proteases KLK7 and KLK14
-
additional information
-
not inhibited by lympho-epithelial Kazal type inhibitor fragments D1 and D6
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
1.675
tosyl-Gly-L-Pro-L-Arg-4-nitroanilide
-
pH 8.0, temperature not specified in the publication
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
KLK14 expression significantly higher compared to normal breast tissues
KLK13 and KLK14 cannot be considered as specific markers for non-small-cell lung cancer
KLK14 expression is significantly lower in individuals with clinically delayed liquefaction. Crucial cascade-mediated function of KLK14 in regulating the coagulation and liquefaction of human semen
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
aberrant enzyme activity is associated with inflammatory skin diseases such as Netherton syndrome but also with various serious forms of cancer
metabolism
both KLK14 and trypsin are able to activate MAP kinase signalling in the human HEK cells as does the PAR-activating peptide, while KLK8 does not
physiological function
additional information
enzyme structure homology modelling using crystal structure, PDB 2BDG, overview
physiological function
-
KLK14 (0.0001 mM) induces increases in intracellular Ca2+ in HT-29 cells. KLK14 induces significant extracellular signal-regulated kinases 1 and 2 phosphorylation and HT-29 cell proliferation, presumably by activating proteinase-activated receptor-2
physiological function
human enzyme can activate rat and human proteinase-activated receptor 2, PAR2, calcium signalling, and the enzyme stimulates human PAR2 clustering and internalization
physiological function
the enzyme regulates the components of the hepatocyte growth factor/Met axis, pro-hepatocyte growth factor and hepatocyte growth factorF-activator inhibitor 1A and 1B
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). KLK14_HUMAN
267
0
29122
Swiss-Prot
Secretory Pathway (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
glycoprotein
the lower catalytic efficiency observed against a peptide substrate for insect cell expressed KLK14, compared with the previously reported yeast expressed protease, is possibly due to N-glycosylation present on the former but not the latter
proteolytic modification
pro-kallikrein 14 iss activated with thermolysin
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene KLK14, recombinant expression in Spodoptera frugiperda Sf9 insect cells
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
diagnostics
mRNA overexpression of kallikrein 14 is an independent predictor of poor overall survival in chronic lymphocytic leukemia patients
medicine
medicine
-
KLK14 has the prognostic potential to recognize prostate cancer patients at higher risk of disease recurrence after radical prostatectomy. As an independent factor, KLK14 is expected to supplement postoperative prostate-specific antigen values for a more precise prognosis
medicine
-
normal salivary glands, pleomorphic adenoma, adenoid cystic carcinoma and mucoepidermoid carcinoma show strong expression of KLK14 in ductal and non-ductal cells. Both pleomorphic adenoma and adenoid cystic carcinoma show higher KLK14 levels than normal glands and mucoepidermoid carcinoma tissues. There are no statistically significant associations between levels of KLK14 and clinical parameters
medicine
-
study on the clinical value of seminal kallikreins in the evaluation of semen quality and differential diagnosis and etiology of abnormal liquefaction and/or viscosity. Combination of KLK2, 3, 13, and 14 and KLK1, 2, 5, 6, 7, 8, 10, 13, and 14 shows very strong discriminatory potential for semen liquefaction and viscosity, respectively. Liquefaction state is associated with several parameters of sperm motility. KLK14 is differentially expressed in asthenospermic cases
medicine
-
KLK14 and its receptor proteinase-activated receptor-2 represent therapeutic targets for colon tumorigenesis
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (Q9P0G3)
Hooper, J.D.; Bui, L.T.; Rae, F.K.; Harvey, T.J.; Myers, S.A; Ashworth, L.K.; Clements, J.A.
Identification and characterization of KLK14, novel kallikrein serine protease gene located on human chromosome 19q13.4 and expressed in prostate and skeletal muscle
Genomics
73
117-122
2001
Homo sapiens (Q9P0G3), Homo sapiens
Felber, L.M.; Borgono, C.A.; Cloutier, S.M.; Kuendig, C.; Kishi, T.; Ribeiro Chagas, J.; Jichlinski, P.; Gygi, C.M.; Leisinger, H.J.; Diamandis, E.P.; Deperthes, D.
Enzymatic profiling of human kallikrein 14 using phage-display substrate technology
Biol. Chem.
386
291-298
2005
Homo sapiens
Fritzsche, F.; Gansukh, T.; Borgono, C.A.; Burkhardt, M.; Pahl, S.; Mayordomo, E.; Winzer, K.J.; Weichert, W.; Denkert, C.; Jung, K.; Stephan, C.; Dietel, M.; Diamandis, E.P.; Dahl, E.; Kristiansen, G.
Expression of human Kallikrein 14 (KLK14) in breast cancer is associated with higher tumour grades and positive nodal status
Br. J. Cancer
94
540-547
2006
Homo sapiens
Felber, L.M.; Kuendig, C.; Borgono, C.A.; Chagas, J.R.; Tasinato, A.; Jichlinski, P.; Gygi, C.M.; Leisinger, H.J.; Diamandis, E.P.; Deperthes, D.; Cloutier, S.M.
Mutant recombinant serpins as highly specific inhibitors of human kallikrein 14
FEBS J.
273
2505-2514
2006
Homo sapiens
Stefansson, K.; Brattsand, M.; Ny, A.; Glas, B.; Egelrud, T.
Kallikrein-related peptidase 14 may be a major contributor to trypsin-like proteolytic activity in human stratum corneum
Biol. Chem.
387
761-768
2006
Homo sapiens (Q9P0G3), Homo sapiens
Emami, N.; Diamandis, E.P.
Human kallikrein-related peptidase 14 (KLK14) is a new activator component of the KLK proteolytic cascade. Possible function in seminal plasma and skin
J. Biol. Chem.
283
3031-3041
2008
Homo sapiens (Q9P0G3), Homo sapiens
Deraison, C.; Bonnart, C.; Lopez, F.; Besson, C.; Robinson, R.; Jayakumar, A.; Wagberg, F.; Brattsand, M.; Hachem, J.P.; Leonardsson, G.; Hovnanian, A.
LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction
Mol. Biol. Cell
18
3607-3619
2007
Homo sapiens
Planque, C.; Blechet, C.; Ayadi-Kaddour, A.; Heuze-Vourch, N.; Dumont, P.; Guyetant, S.; Diamandis, E.P.; El Mezni, F.; Courty, Y.
Quantitative RT-PCR analysis and immunohistochemical localization of the kallikrein-related peptidases 13 and 14 in lung
Biol. Chem.
389
781-786
2008
Homo sapiens (Q9P0G3), Homo sapiens
Emami, N.; Deperthes, D.; Malm, J.; Diamandis, E.P.
Major role of human KLK14 in seminal clot liquefaction
J. Biol. Chem.
283
19561-19569
2008
Homo sapiens (Q9P0G3), Homo sapiens
Rabien, A.; Fritzsche, F.; Jung, M.; Diamandis, E.P.; Loening, S.A.; Dietel, M.; Jung, K.; Stephan, C.; Kristiansen, G.
High expression of KLK14 in prostatic adenocarcinoma is associated with elevated risk of prostate-specific antigen relapse
Tumour Biol.
29
1-8
2008
Homo sapiens
Emami, N.; Scorilas, A.; Soosaipillai, A.; Earle, T.; Mullen, B.; Diamandis, E.P.
Association between kallikrein-related peptidases (KLKs) and macroscopic indicators of semen analysis: their relation to sperm motility
Biol. Chem.
390
921-929
2009
Homo sapiens
Hashem, N.N.; Mara, T.W.; Mohamed, M.; Zhang, I.; Fung, K.; Kwan, K.F.; Daley, T.D.; Diamandis, E.P.; Darling, M.R.
Human kallikrein 14 (KLK14) expression in salivary gland tumors
Int. J. Biol. Markers
25
32-37
2010
Homo sapiens
Meyer-Hoffert, U.; Wu, Z.; Kantyka, T.; Fischer, J.; Latendorf, T.; Hansmann, B.; Bartels, J.; He, Y.; Glaeser, R.; Schroeder, J.M.
Isolation of Spink6 in human skin: a selective inhibitor of kallikrein-related peptidases
J. Biol. Chem.
285
32174-32181
2010
Homo sapiens
Gratio, V.; Loriot, C.; Virca, G.D.; Oikonomopoulou, K.; Walker, F.; Diamandis, E.P.; Hollenberg, M.D.; Darmoul, D.
Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells
Am. J. Pathol.
179
2625-2636
2011
Homo sapiens
de Veer, S.J.; Swedberg, J.E.; Parker, E.A.; Harris, J.M.
Non-combinatorial library screening reveals subsite cooperativity and identifies new high-efficiency substrates for kallikrein-related peptidase 14
Biol. Chem.
393
331-341
2012
Homo sapiens (Q9P0G3)
Ramachandran, R.; Eissa, A.; Mihara, K.; Oikonomopoulou, K.; Saifeddine, M.; Renaux, B.; Diamandis, E.; Hollenberg, M.D.
Proteinase-activated receptors (PARs): differential signalling by kallikrein-related peptidases KLK8 and KLK14
Biol. Chem.
393
421-427
2012
Homo sapiens (Q9P0G3), Homo sapiens
Reid, J.C.; Bennett, N.C.; Stephens, C.R.; Carroll, M.L.; Magdolen, V.; Clements, J.A.; Hooper, J.D.
In vitro evidence that KLK14 regulates the components of the HGF/Met axis, pro-HGF and HGF-activator inhibitor 1A and 1B
Biol. Chem.
397
1299-1305
2016
Homo sapiens (Q9P0G3)
Ulbricht, D.; Tindall, C.A.; Oertwig, K.; Hanke, S.; Straeter, N.; Heiker, J.T.
Kallikrein-related peptidase 14 is the second KLK protease targeted by the serpin vaspin
Biol. Chem.
399
1079-1084
2018
Homo sapiens (Q9P0G3)
Kontos, C.K.; Adamopoulos, P.G.; Papageorgiou, S.G.; Pappa, V.; Scorilas, A.
mRNA overexpression of kallikrein-related peptidase 14 (KLK14) is an independent predictor of poor overall survival in chronic lymphocytic leukemia patients
Clin. Chem. Lab. Med.
54
315-324
2016
Homo sapiens (Q9P0G3), Homo sapiens
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