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Acute Lung Injury
Pseudomonas aeruginosa protease IV degrades surfactant proteins and inhibits surfactant host defense and biophysical functions.
Brain Injuries, Traumatic
Interest of workplace support for returning to work after a traumatic brain injury: a retrospective study.
Carcinoma
[Histochemical and ultrastructural investigations on invasive growth of tumour. I. Enzyme-histochemical investigations (author's transl)]
Cholangitis
[An extremely elderly patient with choledocholithiasis and many complications]
Choledocholithiasis
[An extremely elderly patient with choledocholithiasis and many complications]
Chronic Periodontitis
Identification of a critical bacterial peptidase involved in chronic periodontitis: PG0026 is the C-terminal signal peptidase of a novel secretion system of Porphyromonas gingivalis.
Classical Swine Fever
Classical swine fever virus leader proteinase Npro is not required for viral replication in cell culture.
coagulation factor xa deficiency
Human coagulation factor X deficiency caused by a mutant signal peptide that blocks cleavage by signal peptidase but not targeting and translocation to the endoplasmic reticulum.
Corneal Injuries
Pseudomonas aeruginosa protease IV produces corneal damage and contributes to bacterial virulence.
Corneal Injuries
Pseudomonas aeruginosa protease IV: a corneal virulence factor of low immunogenicity.
Corneal Injuries
Pseudomonas deficient in protease IV has significantly reduced corneal virulence.
Cystic Fibrosis
Abnormal protein translocation as the elusive cause of cystic fibrosis: an hypothesis.
Cystic Fibrosis
Protease IV production in Pseudomonas aeruginosa from the lungs of adults with cystic fibrosis.
Demyelinating Diseases
A virus-induced molecular mimicry model of multiple sclerosis.
Dengue
Cotranslational membrane insertion of the serine proteinase precursor NS2B-NS3(Pro) of dengue virus type 2 is required for efficient in vitro processing and is mediated through the hydrophobic regions of NS2B.
Dengue
In vitro processing of dengue virus structural proteins: cleavage of the pre-membrane protein.
Dengue
The Natural Product Cavinafungin Selectively Interferes with Zika and Dengue Virus Replication by Inhibition of the Host Signal Peptidase.
Diabetes Insipidus, Neurogenic
Possible involvement of inefficient cleavage of preprovasopressin by signal peptidase as a cause for familial central diabetes insipidus.
Encephalomyelitis
Viral delivery of an epitope from Haemophilus influenzae induces central nervous system autoimmune disease by molecular mimicry.
Eye Infections
Characterization of protease IV expression in Pseudomonas aeruginosa clinical isolates.
Factor X Deficiency
Human coagulation factor X deficiency caused by a mutant signal peptide that blocks cleavage by signal peptidase but not targeting and translocation to the endoplasmic reticulum.
Foot-and-Mouth Disease
A conserved domain in the leader proteinase of foot-and-mouth disease virus is required for proper subcellular localization and function.
Foot-and-Mouth Disease
Ability of foot-and-mouth disease virus to form plaques in cell culture is associated with suppression of alpha/beta interferon.
Foot-and-Mouth Disease
Analysis of the leader proteinase (L(pro)) region of type A foot-and-mouth disease virus with due emphasis on phylogeny and evolution of the emerging VP3(59)-deletion lineage from India.
Foot-and-Mouth Disease
Characterization of a chimeric foot-and-mouth disease virus bearing a bovine rhinitis B virus leader proteinase.
Foot-and-Mouth Disease
Comparison of self-processing of foot-and-mouth disease virus leader proteinase and porcine reproductive and respiratory syndrome virus leader proteinase nsp1?.
Foot-and-Mouth Disease
Crystallization and preliminary X-ray diffraction studies of the Lb proteinase from foot-and-mouth disease virus.
Foot-and-Mouth Disease
Degradation of nuclear factor kappa B during foot-and-mouth disease virus infection.
Foot-and-Mouth Disease
Differential gene expression in bovine cells infected with wild type and leaderless foot-and-mouth disease virus.
Foot-and-Mouth Disease
Eukaryotic initiation factor 4GI is a poor substrate for HIV-1 proteinase.
Foot-and-Mouth Disease
Extremely efficient cleavage of eIF4G by picornaviral proteinases L and 2A in vitro.
Foot-and-Mouth Disease
Foot-and-mouth disease virus (FMDV) leader proteinase negatively regulates the porcine interferon-?1 pathway.
Foot-and-Mouth Disease
Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced RANTES transcription in PK-15 cells.
Foot-and-Mouth Disease
Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced type I interferon transcription by decreasing interferon regulatory factor 3/7 in protein levels.
Foot-and-Mouth Disease
Foot-and-mouth disease virus leader proteinase: a papain-like enzyme requiring an acidic environment in the active site.
Foot-and-Mouth Disease
Foot-and-mouth disease virus leader proteinase: involvement of C-terminal residues in self-processing and cleavage of eIF4GI.
Foot-and-Mouth Disease
Foot-and-mouth disease virus leader proteinase: purification of the Lb form and determination of its cleavage site on eIF-4 gamma.
Foot-and-Mouth Disease
Foot-and-mouth disease virus leader proteinase: specificity at the P2 and P3 positions and comparison with other papain-like enzymes.
Foot-and-Mouth Disease
Foot-and-mouth disease virus leader proteinase: structural insights into the mechanism of intermolecular cleavage.
Foot-and-Mouth Disease
Impairment of the DeISGylation Activity of Foot-and-Mouth Disease Virus Lpro Causes Attenuation In Vitro and In Vivo.
Foot-and-Mouth Disease
Inoculation of swine with foot-and-mouth disease SAP-mutant virus induces early protection against disease.
Foot-and-Mouth Disease
Molecular phylogeny of leader proteinase gene of type A of Foot-and-mouth disease virus from India.
Foot-and-Mouth Disease
NMR analysis of the interaction of picornaviral proteinases Lb and 2A with their substrate eukaryotic initiation factor 4GII.
Foot-and-Mouth Disease
Phylogenetic analysis of the leader proteinase (Lpro) region of Indian foot and mouth disease serotype O isolates.
Foot-and-Mouth Disease
Recognition of eukaryotic initiation factor 4G isoforms by picornaviral proteinases.
Foot-and-Mouth Disease
Residue L143 of the Foot-and-Mouth Disease Virus Leader Proteinase Is a Determinant of Cleavage Specificity.
Foot-and-Mouth Disease
Structural and biochemical features distinguish the foot-and-mouth disease virus leader proteinase from other papain-like enzymes.
Foot-and-Mouth Disease
The binding of foot-and-mouth disease virus leader proteinase to eIF4GI involves conserved ionic interactions.
Foot-and-Mouth Disease
The foot-and-mouth disease virus leader proteinase gene is not required for viral replication.
Foot-and-Mouth Disease
The leader proteinase of foot-and-mouth disease virus inhibits the induction of beta interferon mRNA and blocks the host innate immune response.
Foot-and-Mouth Disease
The Leader Proteinase of Foot-and-Mouth Disease Virus Negatively Regulates the Type I Interferon Pathway by Acting as a Viral Deubiquitinase.
Foot-and-Mouth Disease
The leader proteinase of foot-and-mouth disease virus: structure-function relationships in a proteolytic virulence factor.
Foot-and-Mouth Disease
The structures of picornaviral proteinases.
Hepatitis
Methodologic research on TIMP-1, TIMP-2 detection as a new diagnostic index for hepatic fibrosis and its significance.
Hepatitis A
The structures of picornaviral proteinases.
Hepatitis C
Analysis of the glycosylation sites of hepatitis C virus (HCV) glycoprotein E1 and the influence of E1 glycans on the formation of the HCV glycoprotein complex.
Hepatitis C
Characterization of the cleavage of signal peptide at the C-terminus of hepatitis C virus core protein by signal peptide peptidase.
Hepatitis C
Efficiency of E2-p7 Processing Modulates Production of Infectious Hepatitis C Virus.
Hepatitis C
Efficient cleavage by signal peptide peptidase requires residues within the signal peptide between the core and E1 proteins of hepatitis C virus strain J1.
Hepatitis C
Formation and intracellular localization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia and Sindbis viruses.
Hepatitis C
Functional hepatitis C virus envelope glycoproteins.
Hepatitis C
Glycosylation of hepatitis C virus envelope proteins.
Hepatitis C
Maturation of hepatitis C virus core protein by signal peptide peptidase is required for virus production.
Hepatitis C
Nuclear localization of the truncated hepatitis C virus core protein with its hydrophobic C terminus deleted.
Hepatitis C
Regulation of hepatitis C virus polyprotein processing by signal peptidase involves structural determinants at the p7 sequence junctions.
Hepatitis C
Sequential processing of hepatitis C virus core protein by host cell signal peptidase and signal peptide peptidase: a reassessment.
Hepatitis C
Signal Peptidase Complex Subunit 1 Participates in the Assembly of Hepatitis C Virus through an Interaction with E2 and NS2.
Hepatitis C
Signal peptide peptidase promotes the formation of hepatitis C virus non-enveloped particles and is captured on the viral membrane during assembly.
Hepatitis C
Structural analysis of hepatitis C virus core-E1 signal peptide and requirements for cleavage of the genotype 3a signal sequence by signal peptide peptidase.
Hepatitis C
Topological changes in the transmembrane domains of hepatitis C virus envelope glycoproteins.
Hepatitis, Chronic
Methodologic research on TIMP-1, TIMP-2 detection as a new diagnostic index for hepatic fibrosis and its significance.
Infections
Ability of foot-and-mouth disease virus to form plaques in cell culture is associated with suppression of alpha/beta interferon.
Infections
Calcium and magnesium enhance the production of Pseudomonas aeruginosa protease IV, a corneal virulence factor.
Infections
Comparison of potential protection induced by three vaccination strategies (DNA/DNA, Protein/Protein and DNA/Protein) against Leishmania major infection using Signal Peptidase type I in BALB/c mice.
Infections
Differential genotypic signatures of Toll-like receptor polymorphisms among dengue-chikungunya mono- and co-infected Eastern Indian patients.
Infections
Evaluation of the type I signal peptidases as antibacterial target for biofilm-associated infections of Staphylococcus epidermidis.
Infections
Iron facilitates the RetS-Gac-Rsm cascade to inversely regulate protease IV (piv) expression via the sigma factor PvdS in Pseudomonas aeruginosa.
Infections
Protease IV production in Pseudomonas aeruginosa from the lungs of adults with cystic fibrosis.
Infections
Protease IV, a unique extracellular protease and virulence factor from Pseudomonas aeruginosa.
Infections
Pseudomonas aeruginosa Keratitis: Protease IV and PASP as Corneal Virulence Mediators.
Infections
Pseudomonas aeruginosa Possesses Two Putative Type I Signal Peptidases, LepB and PA1303, Each with Distinct Roles in Physiology and Virulence.
Infections
Pseudomonas keratitis. The role of an uncharacterized exoprotein, protease IV, in corneal virulence.
Infections
Roles of the Site 2 Protease Eep in Staphylococcus aureus.
Infections
Secretion of the chlamydial virulence factor CPAF requires the Sec-dependent pathway.
Infections
The biosynthesis of membrane-bound M13 coat protein. Energetics and assembly intermediates.
Infections
The capability of Pseudomonas aeruginosa to recruit zinc under conditions of limited metal availability is affected by inactivation of the ZnuABC transporter.
Influenza, Human
Biochemical properties of the P42 protein encoded by RNA segment 6 of influenza C virus.
Influenza, Human
Influenza C virus CM2 protein is produced from a 374-amino-acid protein (P42) by signal peptidase cleavage.
Keratitis
Protease IV production in Pseudomonas aeruginosa from the lungs of adults with cystic fibrosis.
Keratitis
Pseudomonas aeruginosa Keratitis: Protease IV and PASP as Corneal Virulence Mediators.
Keratitis
Pseudomonas aeruginosa protease IV produces corneal damage and contributes to bacterial virulence.
Keratitis
Pseudomonas deficient in protease IV has significantly reduced corneal virulence.
Keratitis
Pseudomonas keratitis. The role of an uncharacterized exoprotein, protease IV, in corneal virulence.
Keratitis
Pseudomonas keratitis: protease IV gene conservation, distribution, and production relative to virulence and other Pseudomonas proteases.
Leishmaniasis
Comparison of potential protection induced by three vaccination strategies (DNA/DNA, Protein/Protein and DNA/Protein) against Leishmania major infection using Signal Peptidase type I in BALB/c mice.
Leishmaniasis
Type I signal peptidase from Leishmania is a target of the immune response in human cutaneous and visceral leishmaniasis.
Leishmaniasis, Cutaneous
Comparison of potential protection induced by three vaccination strategies (DNA/DNA, Protein/Protein and DNA/Protein) against Leishmania major infection using Signal Peptidase type I in BALB/c mice.
Leishmaniasis, Visceral
Type I signal peptidase from Leishmania is a target of the immune response in human cutaneous and visceral leishmaniasis.
Liver Cirrhosis
Methodologic research on TIMP-1, TIMP-2 detection as a new diagnostic index for hepatic fibrosis and its significance.
Malaria
Isolation and characterization of type I signal peptidase of different malaria parasites.
Mouth Diseases
Phylogenetic analysis of the leader proteinase (Lpro) region of Indian foot and mouth disease serotype O isolates.
Mouth Diseases
Recognition of eukaryotic initiation factor 4G isoforms by picornaviral proteinases.
Neoplasms
Recent Advances in Lung Cancer Immunotherapy: Input of T-Cell Epitopes Associated With Impaired Peptide Processing.
Neoplasms
[Histochemical and ultrastructural investigations on invasive growth of tumour. I. Enzyme-histochemical investigations (author's transl)]
Niemann-Pick Diseases
High performance liquid chromatography for the detection of homozygotes and heterozygotes of Niemann-Pick disease.
Pneumonia
Mycoplasma hyopneumoniae type I signal peptidase: Expression and evaluation of its diagnostic potential.
Pneumonia, Pneumococcal
Pseudomonas aeruginosa Protease IV Exacerbates Pneumococcal Pneumonia and Systemic Disease.
Porcine Reproductive and Respiratory Syndrome
Comparison of self-processing of foot-and-mouth disease virus leader proteinase and porcine reproductive and respiratory syndrome virus leader proteinase nsp1?.
Retinoblastoma
A unique cathepsin-like protease isolated from CV-1 cells is involved in rapid degradation of retinoblastoma susceptibility gene product, RB, and transcription factor SP1.
Retinoblastoma
Molecular cloning of cDNA for SPase, a monkey cathepsin L orthologue.
Rhinitis
Characterization of a chimeric foot-and-mouth disease virus bearing a bovine rhinitis B virus leader proteinase.
Rocky Mountain Spotted Fever
Molecular and functional analysis of the lepB gene, encoding a type I signal peptidase from Rickettsia rickettsii and Rickettsia typhi.
Rubella
Mutational analysis of the arginine residues in the E2-E1 junction region on the proteolytic processing of the polyprotein precursor of rubella virus.
Rubella
The influence of capsid protein cleavage on the processing of E2 and E1 glycoproteins of rubella virus.
signal peptidase i deficiency
Compensatory effect of the minor Streptomyces lividans type I signal peptidases on the SipY major signal peptidase deficiency as determined by extracellular proteome analysis.
Spotted Fever Group Rickettsiosis
Molecular and functional analysis of the lepB gene, encoding a type I signal peptidase from Rickettsia rickettsii and Rickettsia typhi.
Starvation
Role of Clp protease subunits in degradation of carbon starvation proteins in Escherichia coli.
Stomach Neoplasms
Correction: Signal peptidase complex 18, encoded by SEC11A, contributes to progression via TGF-? secretion in gastric cancer.
Stomach Neoplasms
Signal peptidase complex 18, encoded by SEC11A, contributes to progression via TGF-? secretion in gastric cancer.
Tetanus
Bacterial protease inhibitors.
Tuberculosis
A Target-Based Whole Cell Screen Approach To Identify Potential Inhibitors of Mycobacterium tuberculosis Signal Peptidase.
Tuberculosis
Evaluation of signal peptide prediction algorithms for identification of mycobacterial signal peptides using sequence data from proteomic methods.
Tuberculosis
HLA-B*35-restricted CD8(+)-T-cell epitope in Mycobacterium tuberculosis Rv2903c.
Tuberculosis
Inhibition of the sole type I signal peptidase of Mycobacterium tuberculosis is bactericidal under replicating and nonreplicating conditions.
Tuberculosis
Resisting resistant Mycobacterium tuberculosis naturally: Mechanistic insights into the inhibition of the parasite's sole signal peptidase Leader peptidase B.
Typhus, Endemic Flea-Borne
Molecular and functional analysis of the lepB gene, encoding a type I signal peptidase from Rickettsia rickettsii and Rickettsia typhi.
Virus Diseases
Foot-and-Mouth Disease Virus Viroporin 2B Antagonizes RIG-I-Mediated Antiviral Effects by Inhibition of Its Protein Expression.
Whooping Cough
Co-expression of the Bordetella pertussis leader peptidase I results in enhanced processing and expression of the pertussis toxin S1 subunit in Escherichia coli.
Whooping Cough
Expression and secretion of the S-1 subunit and C180 peptide of pertussis toxin in Escherichia coli.
Yellow Fever
Cleavage at a novel site in the NS4A region by the yellow fever virus NS2B-3 proteinase is a prerequisite for processing at the downstream 4A/4B signalase site.
Yellow Fever
Mutagenesis of the signal sequence of yellow fever virus prM protein: enhancement of signalase cleavage In vitro is lethal for virus production.
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