Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Abortion, Spontaneous
CD49a regulates the function of human decidual natural killer cells.
Abortion, Spontaneous
Granulysin produced by uterine natural killer cells induces apoptosis of extravillous trophoblasts in spontaneous abortion.
Abortion, Spontaneous
Large granular lymphocytes (LGLS) activity in women with spontaneous abortions during the 1st trimester of gestation.
Acute Coronary Syndrome
Granzyme B as a novel factor involved in cardiovascular diseases.
Acute Coronary Syndrome
Increased granzyme B production from peripheral blood mononuclear cells in patients with acute coronary syndrome.
Acute Coronary Syndrome
Plasma granzyme B in ST elevation myocardial infarction versus non-ST elevation acute coronary syndrome: comparisons with IL-18 and fractalkine.
Acute Lung Injury
Fas/FasL-dependent apoptosis of alveolar cells after lipopolysaccharide-induced lung injury in mice.
Acute Lung Injury
Granzyme B deficiency exacerbates lung inflammation in mice after acute lung injury.
Acute-On-Chronic Liver Failure
NKG2D modulates aggravation of liver inflammation by activating NK cells in HBV infection.
Adenocarcinoma
Generation of recombinant canine interleukin-15 and evaluation of its effects on the proliferation and function of canine NK cells.
Adenocarcinoma
TRAIL-Receptor 4 Modulates ?? T Cell-Cytotoxicity Toward Cancer Cells.
Adenocarcinoma of Lung
Estrogen and cigarette sidestream smoke particulate matter exhibit ER?-dependent tumor-promoting effects in lung adenocarcinoma cells.
Albuminuria
Anti-CD8 monoclonal antibody therapy is effective in the prevention and treatment of experimental autoimmune glomerulonephritis.
Alopecia
Induction of alopecia areata in C3H/HeJ mice using cryopreserved lymphocytes.
Alopecia
Type 1 interferon signature in the scalp lesions of alopecia areata.
Alopecia Areata
Role of cytotoxic T cells in chronic alopecia areata.
Alopecia Areata
Type 1 interferon signature in the scalp lesions of alopecia areata.
Anemia, Aplastic
Involvement of cytotoxic granules in the apoptosis of aplastic anaemia.
Aneurysm
CD8 T lymphocytes do not express cytotoxic proteins in coronary artery aneurysms in acute Kawasaki disease.
Angina, Unstable
Increased granzyme B production from peripheral blood mononuclear cells in patients with acute coronary syndrome.
Anthrax
Proteases as activators for cytotoxic prodrugs in antitumor therapy.
Aortic Aneurysm
Structural and biomolecular changes in aorta and pulmonary trunk of patients with aortic aneurysm and valve disease: implications for the Ross procedure.
Aortic Aneurysm, Abdominal
Perforin-independent extracellular granzyme B activity contributes to abdominal aortic aneurysm.
Appendicitis
Immunohistochemical analysis of granzyme B in non-perforated appendicitis--short communication.
Arthritis
Monoclonal anti-CD8 therapy induces disease amelioration in the K/BxN mouse model of spontaneous chronic polyarthritis.
Arthritis
Raised granzyme B levels are associated with erosions in patients with early rheumatoid factor positive rheumatoid arthritis.
Arthritis, Rheumatoid
A genetic variant in granzyme B is associated with progression of joint destruction in rheumatoid arthritis.
Arthritis, Rheumatoid
Chronic clonal proliferative disease of gamma-delta (gammadelta) T-cells in a patient with rheumatoid arthritis and neutropenia: lack of the morphology and the immunophenotype of large granular lymphocytes.
Arthritis, Rheumatoid
Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue.
Arthritis, Rheumatoid
Elevated serum granzyme B levels are associated with disease activity and joint damage in patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Etanercept reduces the serum levels of macrophage chemotactic protein-1 in patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Expression of granzyme B in human articular chondrocytes.
Arthritis, Rheumatoid
Granzyme B and natural killer (NK) cell death.
Arthritis, Rheumatoid
Granzyme B induces apoptosis of chondrocytes with natural killer cell-like cytotoxicity in rheumatoid arthritis.
Arthritis, Rheumatoid
Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in rheumatoid arthritis.
Arthritis, Rheumatoid
Macrophages express granzyme B in the lesion areas of atherosclerosis and rheumatoid arthritis.
Arthritis, Rheumatoid
Proteolysis by Granzyme B Enhances Presentation of Autoantigenic Peptidylarginine Deiminase 4 Epitopes in Rheumatoid Arthritis.
Arthritis, Rheumatoid
Raised granzyme B levels are associated with erosions in patients with early rheumatoid factor positive rheumatoid arthritis.
Arthritis, Rheumatoid
Serum levels of granzyme B decrease in patients with rheumatoid arthritis responding to abatacept.
Asthma
Altered sputum granzyme B and granzyme B/proteinase inhibitor-9 in patients with non-eosinophilic asthma.
Asthma
Blood cytotoxic/inflammatory mediators in non-eosinophilic asthma.
Asthma
Decrease of cytotoxic T cells in allergic asthma correlates with total serum immunglobulin E.
Asthma
Granule Cytotoxic Activity and Oxidative DNA Damage in Smoking and Nonsmoking Patients With Asthma.
Asthma
Granzyme B, a novel mediator of allergic inflammation: its induction and release in blood basophils and human asthma.
Asthma
Increase in granzyme B+ lymphocytes and soluble granzyme B in bronchoalveolar lavage of allergen challenged patients with atopic asthma.
Asthma
Lung function decline in asthma patients with elevated bronchial CD8, CD4 and CD3 cells.
Asthma
Maternal diesel particle exposure promotes offspring asthma through NK cell-derived granzyme B.
Astrocytoma
Differential PARP cleavage: an indication for existence of multiple forms of cell death in human gliomas.
Ataxia Telangiectasia
Temporal changes in mouse aortic wall gene expression during the development of elastase-induced abdominal aortic aneurysms.
Atherosclerosis
Granzyme B in atherosclerosis and transplant vascular disease: association with cell death and atherosclerotic disease severity.
Atherosclerosis
Macrophages express granzyme B in the lesion areas of atherosclerosis and rheumatoid arthritis.
Atherosclerosis
Perforin and granzyme B have separate and distinct roles during atherosclerotic plaque development in apolipoprotein E knockout mice.
Atherosclerosis
Peripheral leucocytes and tissue gene expression of granzyme B/perforin system and serpinB9: Impact on inflammation and insulin resistance in coronary atherosclerosis.
Atherosclerosis
The role of Granzyme B in atheromatous diseases.
Autoimmune Diseases
Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity.
Autoimmune Diseases
Contribution to antimitochondrial antibody production: cleavage of pyruvate dehydrogenase complex-E2 by apoptosis-related proteases.
Autoimmune Diseases
Granzyme B and natural killer (NK) cell death.
Autoimmune Diseases
Granzyme B is dispensable for immunologic tolerance to self in a murine model of systemic lupus erythematosus.
Autoimmune Diseases
Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells.
Autoimmune Diseases
Increase in activated CD8+ T lymphocytes expressing perforin and granzyme B correlates with disease activity in patients with systemic lupus erythematosus.
Autoimmune Diseases
Unique conformation of cancer autoantigen B23 in hepatoma: a mechanism for specificity in the autoimmune response.
Bacterial Infections
Modulation of the granzyme B inhibitor proteinase inhibitor 9 (PI-9) by activation of lymphocytes and monocytes in vitro and by Epstein-Barr virus and bacterial infection.
Bacteriuria
Transcriptional profiles in urine during acute rejection, bacteriuria, CMV infection and stable graft function after renal transplantation.
Bicuspid Aortic Valve Disease
Structural and biomolecular changes in aorta and pulmonary trunk of patients with aortic aneurysm and valve disease: implications for the Ross procedure.
Blister
Collagen XVII Processing and Blistering Skin Diseases.
Blister
Delayed reactions to drugs show levels of perforin, granzyme B, and Fas-L to be related to disease severity.
Blister
Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis.
Blister
Granzyme B inhibition reduces disease severity in autoimmune blistering diseases.
Blister
Toxic epidermal necrolysis: effector cells are drug-specific cytotoxic T cells.
Brain Diseases
Granzyme A Participates in the Pathogenesis of Infection-Associated Acute Encephalopathy.
Brain Infarction
Granzyme-b is involved in mediating post-ischemic neuronal death during focal cerebral ischemia in rat model.
Brain Injuries
CTL-Derived Granzyme B Participates in Hippocampal Neuronal Apoptosis Induced by Cardiac Arrest and Resuscitation in Rats.
Brain Ischemia
Cleaved ?-Actin May Contribute to DNA Fragmentation Following Very Brief Focal Cerebral Ischemia.
Brain Ischemia
Differential PARP Cleavage: An Indication of Heterogeneous Forms of Cell Death and Involvement of Multiple Proteases in the Infarct of Focal Cerebral Ischemia in Rat.
Brain Ischemia
Granzyme-b is involved in mediating post-ischemic neuronal death during focal cerebral ischemia in rat model.
Breast Diseases
Analysis of the mononuclear inflammatory cell infiltrate in the normal breast, benign proliferative breast disease, in situ and infiltrating ductal breast carcinomas: preliminary observations.
Breast Neoplasms
Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer-Mediated Cytotoxicity.
Breast Neoplasms
An Oncolytic Adenovirus Targeting Transforming Growth Factor ? Inhibits Protumorigenic Signals and Produces Immune Activation: A Novel Approach to Enhance Anti-PD-1 and Anti-CTLA-4 Therapy.
Breast Neoplasms
Apoptosis Markers in Breast Cancer Therapy.
Breast Neoplasms
Defective gammadelta T-cell function and granzyme B gene polymorphism in a cohort of newly diagnosed breast cancer patients.
Breast Neoplasms
Epirubicin pretreatment enhances NK cell-mediated cytotoxicity against breast cancer cells in vitro.
Breast Neoplasms
Expression of endogenous granzyme B in a subset of human primary breast carcinomas.
Breast Neoplasms
Interplay between the levels of estrogen and estrogen receptor controls the level of the granzyme inhibitor, proteinase inhibitor 9 and susceptibility to immune surveillance by natural killer cells.
Breast Neoplasms
Involvement of granzyme B and perforin in suppressing nodal metastasis of cancer cells in breast and lung cancers.
Breast Neoplasms
Low concentrations of the soy phytoestrogen genistein induce proteinase inhibitor 9 and block killing of breast cancer cells by immune cells.
Breast Neoplasms
MICA-G129R: A bifunctional fusion protein increases PRLR-positive breast cancer cell death in co-culture with natural killer cells.
Breast Neoplasms
Serum levels of soluble Fas ligand, granzyme B and cytochrome c during adjuvant chemotherapy of breast cancer.
Breast Neoplasms
The pharmalogical reactivation of p53 function improves breast tumor cell lysis by granzyme B and NK cells through induction of autophagy.
Breast Neoplasms
TLR-activated plasmacytoid dendritic cells inhibit breast cancer cell growth in vitro and in vivo.
Bronchiolitis
Lymphocytic bronchiolitis is associated with inadequate suppression of blood T-cell granzyme B, IFN-gamma, and TNF-alpha.
Bronchiolitis Obliterans
Bronchiolitis obliterans syndrome is associated with increased peripheral blood natural killer and natural killer T-like granzymes, perforin, and T-helper-type 1 pro-inflammatory cytokines.
Bronchiolitis Obliterans
Increased levels of T cell granzyme b in bronchiolitis obliterans syndrome are not suppressed adequately by current immunosuppressive regimens.
Bronchiolitis Obliterans
Targeting peripheral blood pro-inflammatory CD28null T cells and natural killer T-like cells by inhibiting CD137 expression: Possible relevance to treatment of bronchiolitis obliterans syndrome.
Bronchiolitis Obliterans
Up-regulation of alternate co-stimulatory molecules on proinflammatory CD28null T cells in bronchiolitis obliterans syndrome.
Carcinogenesis
Immune response and evasion mechanisms in lip carcinogenesis: An immunohistochemical study.
Carcinoma
A comparative study of granzyme B expression in keratoacanthoma and squamous cell carcinoma.
Carcinoma
Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice.
Carcinoma
Characterization of immunoreactivity with whole-slide imaging and digital analysis in high-grade serous ovarian cancer.
Carcinoma
Comprehensive analysis of marker gene detection and computed tomography for the diagnosis of human lung cancer.
Carcinoma
Correlation of P53 and Granzyme B expression in Oral Squamous Cell Carcinoma with Clinicopathologic Findings.
Carcinoma
Defective granzyme B gene expression and lytic response in T lymphocytes infiltrating human renal cell carcinoma.
Carcinoma
Distinct expression of perforin and granzyme B in lip and oral cavity squamous cell carcinoma.
Carcinoma
DNAX-activating protein 10 co-stimulation enhances the anti-tumor efficacy of chimeric antigen receptor T cells.
Carcinoma
Docosahexaenoic acid inhibits invasion of human RT112 urinary bladder and PT45 pancreatic carcinoma cells via down-modulation of granzyme B expression.
Carcinoma
Enhanced apoptosis of squamous cell carcinoma cells by interleukin-2-activated cytotoxic lymphocytes combined with radiation and anticancer drugs.
Carcinoma
Granzyme B is expressed in urothelial carcinoma and promotes cancer cell invasion.
Carcinoma
Granzyme B-truncated VEGF fusion protein represses angiogenesis and tumor growth of OSCC.
Carcinoma
High levels of granzyme B expression in invasive cervical carcinoma correlates to poor response to treatment.
Carcinoma
Immunohistochemical localization of granzyme B in peritumoral infiltrates of basal cell carcinoma.
Carcinoma
Implication of caspase-3 and granzyme B expression and activity in spleenocytes of ehrlich ascites carcinoma mice subjected to immunotherapy.
Carcinoma
Increased frequency of Foxp3+ regulatory T cells in mice with hepatocellular carcinoma.
Carcinoma
Lack of granzyme expression in T lymphocytes indicates poor cytotoxic T lymphocyte activation in human papillomavirus-associated cervical carcinomas.
Carcinoma
Perforin and granzyme B induce apoptosis in FasL-resistant colon carcinoma cells.
Carcinoma
Solid tumor-targeted infiltrating cytotoxic T lymphocytes retained by a superantigen fusion protein.
Carcinoma
Synergy between hemagglutinin 2 (HA2) subunit of influenza fusogenic membrane glycoprotein and oncolytic Newcastle disease virus suppressed tumor growth and further enhanced by Immune checkpoint PD-1 blockade.
Carcinoma
T cell receptor-zeta and granzyme B expression in mononuclear cell infiltrates in normal colon mucosa and colon carcinoma.
Carcinoma
The clinicopathological significance of the expression of Granzyme B in oral squamous cell carcinoma.
Carcinoma
Trichosanthin cooperates with Granzyme B to restrain tumor formation in tongue squamous cell carcinoma.
Carcinoma
Tumor infiltrating lymphocytes differ in invasive micropapillary carcinoma and medullary carcinoma of breast.
Carcinoma, Basal Cell
Immunohistochemical localization of granzyme B in peritumoral infiltrates of basal cell carcinoma.
Carcinoma, Ductal
Analysis of the mononuclear inflammatory cell infiltrate in the normal breast, benign proliferative breast disease, in situ and infiltrating ductal breast carcinomas: preliminary observations.
Carcinoma, Hepatocellular
Dynamic conformations of nucleophosmin (NPM1) at a key monomer-monomer interface affect oligomer stability and interactions with granzyme B.
Carcinoma, Hepatocellular
Enhanced Cancer Immunotherapy with Smad3-Silenced NK-92 Cells.
Carcinoma, Hepatocellular
Mutations to bid cleavage sites protect hepatocytes from apoptosis after ischemia/reperfusion injury.
Carcinoma, Intraductal, Noninfiltrating
Analysis of the mononuclear inflammatory cell infiltrate in the normal breast, benign proliferative breast disease, in situ and infiltrating ductal breast carcinomas: preliminary observations.
Carcinoma, Large Cell
Comprehensive analysis of marker gene detection and computed tomography for the diagnosis of human lung cancer.
Carcinoma, Medullary
Tumor infiltrating lymphocytes differ in invasive micropapillary carcinoma and medullary carcinoma of breast.
Carcinoma, Mucoepidermoid
Immunohistochemical investigations on the expression of programmed cell death ligand 1, human leukocyte antigens G and E, and granzyme B in intraoral mucoepidermoid carcinoma.
Carcinoma, Non-Small-Cell Lung
Frequent T cell responses against immunogenic targets in lung cancer patients for targeted immunotherapy.
Carcinoma, Renal Cell
Defective granzyme B gene expression and lytic response in T lymphocytes infiltrating human renal cell carcinoma.
Carcinoma, Squamous Cell
A comparative study of granzyme B expression in keratoacanthoma and squamous cell carcinoma.
Carcinoma, Squamous Cell
Distinct expression of perforin and granzyme B in lip and oral cavity squamous cell carcinoma.
Carcinoma, Squamous Cell
Enhanced apoptosis of squamous cell carcinoma cells by interleukin-2-activated cytotoxic lymphocytes combined with radiation and anticancer drugs.
Carcinoma, Squamous Cell
Trichosanthin cooperates with Granzyme B to restrain tumor formation in tongue squamous cell carcinoma.
Carcinoma, Squamous Cell
[The effect of human PBMC on the growth of oral squamous cell carcinoma cell].
Cardiovascular Diseases
Granzyme B as a novel factor involved in cardiovascular diseases.
Cardiovascular Diseases
Predictive ability of granzyme B for cardiovascular disease and its direction in change.
Celiac Disease
Decreased expression of protease inhibitor 9, a granzyme B inhibitor, in celiac disease: a potential mechanism in enterocyte destruction and villous atrophy.
Celiac Disease
Evidence that intestinal intraepithelial lymphocytes are activated cytotoxic T cells in celiac disease but not in giardiasis.
Cervical Intraepithelial Neoplasia
Granzyme B as a prognostic marker of cervical intraepithelial neoplasia.
Cervical Intraepithelial Neoplasia
LC3B upregulation by NANOG promotes immune resistance and stem-like property through hyperactivation of EGFR signaling in immune-refractory tumor cells.
Chagas Disease
Characterization of CD4(+) Cytotoxic Lymphocytes and Apoptosis Markers Induced by Trypanossoma cruzi Infection.
Chagas Disease
Differential phenotypic and functional profiles of TcCA-2 -specific cytotoxic CD8+ T cells in the asymptomatic versus cardiac phase in Chagasic patients.
Chagas Disease
Identification of phenotypic markers of B cells from patients with Chagas disease.
Chickenpox
Granzyme B cleaves multiple HSV-1 and VZV gene products and VZV ORF4 inhibits Natural Killer cell dependent cytotoxicity.
Choriocarcinoma
Immune cell profiling in intraplacental and postmolar choriocarcinomas.
Choroiditis
ZIKA virus infection causes persistent chorioretinal lesions.
Coinfection
Coordinated In Vitro Release of Granulysin, Perforin and IFN-? in TB and HIV/TB Co-Infection Associated with Clinical Outcomes before and after Anti-TB Treatment.
Coinfection
Kinetics of Primary and Memory Cytotoxic T Lymphocyte Responses to Herpes Simplex Virus 1 Infection: Granzyme B Mediated CTL Activity.
Colitis
AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice.
Colitis
Evaluation of immune infiltration in the colonic mucosa of patients with ipilimumab-related colitis.
Colitis, Ulcerative
Differential levels of granzyme B, regulatory cytokines, and apoptosis in Crohn's disease and ulcerative colitis at first presentation.
Colitis, Ulcerative
Enhanced intramucosal cytotoxic lymphocyte gene expression in ulcerative colitis.
Colonic Neoplasms
B7-H5 blockade enhances CD8+ T-cell-mediated antitumor immunity in colorectal cancer.
Colonic Neoplasms
Granzyme B PET Imaging of Combined Chemotherapy and Immune Checkpoint Inhibitor Therapy in Colon Cancer.
Colonic Neoplasms
Granzyme B PET Imaging of Immune Checkpoint Inhibitor Combinations in Colon Cancer Phenotypes.
Colonic Neoplasms
Liposomal Delivery of Mitoxantrone and a Cholesteryl Indoximod Prodrug Provides Effective Chemo-immunotherapy in Multiple Solid Tumors.
Colonic Neoplasms
T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice.
Colonic Neoplasms
Tim-3 suppresses the killing effect of V?9V?2?T cells on colon cancer cells by reducing perforin and granzyme B expression.
Colonic Neoplasms
Tumor-derived granzyme B-expressing neutrophils acquire antitumor potential after lipid A treatment.
Colonic Neoplasms
Wnt pathway activator TWS119 enhances the proliferation and cytolytic activity of human ??T cells against colon cancer.
Colorectal Neoplasms
Combination Therapy with EpCAM-CAR-NK-92 Cells and Regorafenib against Human Colorectal Cancer Models.
Colorectal Neoplasms
Cytotoxic T Cells and Granzyme B Associated with Improved Colorectal Cancer Survival in a Prospective Cohort of Older Women.
Colorectal Neoplasms
Epitelial-to-mesenchimal transition and invasion are upmodulated by tumor-expressed granzyme B and inhibited by docosahexaenoic acid in human colorectal cancer cells.
Colorectal Neoplasms
Granzyme B gene polymorphisms, colorectal cancer risk, and metastasis.
Colorectal Neoplasms
Lipid accumulation impairs natural killer cell cytotoxicity and tumor control in the postoperative period.
Colorectal Neoplasms
Low expression of Granzyme B in colorectal cancer is associated with signs of early metastastic invasion.
Colorectal Neoplasms
Sequential metastases of colorectal cancer: Immunophenotypes and spatial distributions of infiltrating immune cells in relation to time and treatments.
Colorectal Neoplasms
T cell receptor-zeta and granzyme B expression in mononuclear cell infiltrates in normal colon mucosa and colon carcinoma.
Colorectal Neoplasms
The Impact of Immune Interaction on the Metastatic Infiltration of Colorectal Carcinoma to Lymph Nodes.
Colorectal Neoplasms
Tumor infiltrating lymphocytes: an intriguing player in the survival of colorectal cancer patients.
Communicable Diseases
Impairment of Granzyme B-Producing Regulatory B Cells Correlates with Exacerbated Rheumatoid Arthritis.
Congenital Abnormalities
Phenotypic and functional characterization of natural killer cells in rheumatoid arthritis-regulation with interleukin-15.
Coronary Aneurysm
CD8 T lymphocytes do not express cytotoxic proteins in coronary artery aneurysms in acute Kawasaki disease.
Coronary Artery Disease
Granzyme B as a novel factor involved in cardiovascular diseases.
Coronary Artery Disease
Plasma granzyme B as a predicting factor of coronary artery disease-Clinical significance in patients with chronic renal failure.
COVID-19
CIGB-258, a peptide derived from human heat-shock protein 60, decreases hyperinflammation in COVID-19 patients.
COVID-19
CXCL10 could drive longer duration of mechanical ventilation during COVID-19 ARDS.
COVID-19
Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73- Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes.
COVID-19
In vitro Interleukin-7 treatment partially rescues MAIT cell dysfunction caused by SARS-CoV-2 infection.
COVID-19
Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients.
COVID-19
Plasma biomarker profiling of PIMS-TS, COVID-19 and SARS-CoV2 seropositive children - a cross-sectional observational study from southern India.
Cowpox
Differential inhibition of the Fas- and granule-mediated cytolysis pathways by the orthopoxvirus cytokine response modifier A/SPI-2 and SPI-1 protein.
Cowpox
Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A.
Cowpox
Myxoma virus Serp2 is a weak inhibitor of granzyme B and interleukin-1beta-converting enzyme in vitro and unlike CrmA cannot block apoptosis in cowpox virus-infected cells.
Cowpox
Subcellular localization of CrmA: identification of a novel leucine-rich nuclear export signal conserved in anti-apoptotic serpins.
Cowpox
The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.
Crohn Disease
Differential levels of granzyme B, regulatory cytokines, and apoptosis in Crohn's disease and ulcerative colitis at first presentation.
Crohn Disease
Role of IL-1ra and Granzyme B as biomarkers in active Crohn's disease patients.
Cysts
Penetration of CD8+ Cytotoxic T Cells into Large Target, Tissue Cysts of Toxoplasma gondii, Leads to Its Elimination.
Cytomegalovirus Infections
Differential cleavage of viral polypeptides by allotypic variants of granzyme B skews immunity to mouse cytomegalovirus.
Cytomegalovirus Infections
Expression of granzyme B during primary cytomegalovirus infection after renal transplantation.
Cytomegalovirus Infections
The Critical Role of IL-15-PI3K-mTOR Pathway in Natural Killer Cell Effector Functions.
Cytomegalovirus Infections
The granzyme B inhibitor SERPINB9 (protease inhibitor 9) circulates in blood and increases on primary cytomegalovirus infection after renal transplantation.
Dengue
Functionality of dengue virus specific memory T cell responses in individuals who were hospitalized or who had mild or subclinical dengue infection.
Dermatitis
Blockade of granzyme B remarkably improves mucocutaneous diseases with keratinocyte death in interface dermatitis.
Dermatitis
Histopathology of drug-induced exanthems: is there a role in diagnosis of drug allergy?
Dermatitis
Infiltration of cytotoxic T cells in drug-induced cutaneous eruptions.
Dermatitis
Relationships among plasma granzyme B level, pruritus and dermatitis in patients with atopic dermatitis.
Dermatitis, Allergic Contact
A comparative study of the expression of cytotoxic proteins in allergic contact dermatitis and psoriasis: spongiotic skin lesions in allergic contact dermatitis are highly infiltrated by T cells expressing perforin and granzyme B.
Dermatitis, Atopic
Perforin and granzyme B may contribute to skin inflammation in atopic dermatitis and psoriasis.
Dermatitis, Atopic
Relationships among plasma granzyme B level, pruritus and dermatitis in patients with atopic dermatitis.
Dermatitis, Contact
Serum concentrations of metalloproteinase 2, metalloproteinase 9 and granzyme B in contact eczema patients.
Dermatitis, Contact
The role of CD4 and CD8 cytotoxic T lymphocytes in the formation of viral vesicles.
Dermatomyositis
The Fas/Fas ligand system, rather than granzyme B, may represent the main mediator of epidermal apoptosis in dermatomyositis.
Diabetes Mellitus
The serine protease granzyme B as an inflammatory marker, in relation to the insulin receptor cleavage in human obesity and type 2 diabetes mellitus.
Diabetes Mellitus, Type 1
Correlation of genetic markers of rejection with biopsy findings following human pancreas transplant.
Diabetes Mellitus, Type 1
Granzyme B is dispensable in the development of diabetes in non-obese diabetic mice.
Diabetes Mellitus, Type 1
Peripheral blood cytotoxic lymphocyte gene transcript levels differ in patients with long-term type 1 diabetes compared to normal controls.
Diabetes Mellitus, Type 2
Increased circulating granzyme B in type 2 diabetes patients with low-grade systemic inflammation.
Diabetes Mellitus, Type 2
The serine protease granzyme B as an inflammatory marker, in relation to the insulin receptor cleavage in human obesity and type 2 diabetes mellitus.
Drug Eruptions
Drug-induced exanthems.
Ectromelia
Caspase-dependent inhibition of mousepox replication by gzmB.
Ectromelia
Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes.
Encephalitis
A substantial number of Rasmussen syndrome patients have increased IgG, CD4(+) T cells, TNFalpha, and Granzyme B in CSF.
Encephalomyelitis, Eastern Equine
Characterisation of immune responses in healthy foals when a multivalent vaccine protocol was initiated at age 90 or 180 days.
Encephalomyelitis, Western Equine
Characterisation of immune responses in healthy foals when a multivalent vaccine protocol was initiated at age 90 or 180 days.
Endometrial Neoplasms
POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer.
Endometriosis
Granzyme B levels and granzyme B polymorphisms in peripheral blood of patients with endometriosis: a preliminary study.
Eosinophilia
Granulysin-Based Lymphocyte Activation Test for Evaluating Drug Causality in Antiepileptics-Induced Severe Cutaneous Adverse Reactions.
Epstein-Barr Virus Infections
Hepatosplenic gamma-delta T-cell lymphoma associated with Epstein-Barr virus.
Epstein-Barr Virus Infections
Primary Epstein-Barr virus infection does not erode preexisting CD8+ T cell memory in humans.
Erythema Multiforme
Detection of granzyme B in CD3-positive cells infiltrated in lesional skin of a dog with erythema multiforme associated with zonisamide.
Esophageal Achalasia
The nature of the myenteric infiltrate in achalasia: an immunohistochemical analysis.
Exanthema
IKZF1 polymorphisms are associated with susceptibility, cytokine levels, and clinical features in systemic lupus erythematosus.
Exanthema
Infiltration of cytotoxic T cells in drug-induced cutaneous eruptions.
Exanthema
Pathogenesis of drug-induced exanthema.
Fowlpox
Preclinical development of HIvax: Human survivin highly immunogenic vaccines.
Gastritis
High Proportion of Granzyme B+ Intraepithelial Lymphocytes Contributes to Epithelial Apoptosis in Helicobacter pylori-Associated Lymphocytic Gastritis.
Giardiasis
Evidence that intestinal intraepithelial lymphocytes are activated cytotoxic T cells in celiac disease but not in giardiasis.
Glioblastoma
Defective Regulation of Membrane TNF? Expression in Dendritic Cells of Glioblastoma Patients Leads to the Impairment of Cytotoxic Activity against Autologous Tumor Cells.
Glioblastoma
Differential PARP cleavage: an indication for existence of multiple forms of cell death in human gliomas.
Glioblastoma
Infiltrating CTLs in human glioblastoma establish immunological synapses with tumorigenic cells.
Glioblastoma
Potential Role of Thymosin-alpha1 Adjuvant Therapy for Glioblastoma.
Glioblastoma
T cells expressing NKG2D chimeric antigen receptors efficiently eliminate glioblastoma and cancer stem cells.
Glioma
Brain microenvironment promotes the final functional maturation of tumor-specific effector CD8+ T cells.
Glioma
Cytotoxic CD4(+) T cells are correlated with better prognosis in Han Chinese grade II and grade III glioma subjects and are suppressed by PD-1 signaling.
Glioma
Functional Change of Effector Tumor-Infiltrating CCR5+CD38+HLA-DR+CD8+ T Cells in Glioma Microenvironment.
Glioma
Glioma cell-derived placental growth factor induces regulatory B cells.
Graft vs Host Disease
FK506 inhibits severe graft-versus-host disease without mediating the involvement of perforin and granzyme B.
Graft vs Host Disease
Genetic variations in T-cell activation and effector pathways modulate alloimmune reactivities after allogeneic hematopoietic stem cell transplantation for patients with hematological malignancies.
Graft vs Host Disease
Granzyme B is not required for regulatory T cell-mediated suppression of graft-versus-host disease.
Graft vs Host Disease
Granzyme B-Mediated Activation-Induced Death of CD4+ T Cells Inhibits Murine Acute Graft-versus-Host Disease.
Graft vs Host Disease
High expression of granzyme B in conventional CD4+ T cells is associated with increased relapses after allogeneic stem cells transplantation in patients with hematological malignancies.
Graft vs Host Disease
The role of granzyme B cluster proteases in cell-mediated cytotoxicity.
Graft vs Host Disease
The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection.
Graft vs Host Disease
[The correlated research of acute graft versus host disease after allogeneic stem cell transplantation]
Granuloma
Immune distribution and localization of phosphoantigen-specific Vgamma2Vdelta2 T cells in lymphoid and nonlymphoid tissues in Mycobacterium tuberculosis infection.
Granuloma
Limited pulmonary mucosal-associated invariant T cell accumulation and activation during Mycobacterium tuberculosis infection in rhesus macaques.
granzyme b deficiency
CD8+ T-cell dysfunction due to cytolytic granule deficiency in persistent Friend retrovirus infection.
granzyme b deficiency
Granzyme B deficiency exacerbates lung inflammation in mice after acute lung injury.
granzyme b deficiency
Granzyme B deficiency promotes osteoblastic differentiation and calcification of vascular smooth muscle cells in hypoxic pulmonary hypertension.
granzyme b deficiency
Granzyme B Deficiency Protects against Angiotensin II-Induced Cardiac Fibrosis.
granzyme b deficiency
Perforin and granzyme B have separate and distinct roles during atherosclerotic plaque development in apolipoprotein E knockout mice.
Hand, Foot and Mouth Disease
GATA1/SP1 and miR-874 mediate enterovirus-71-induced apoptosis in a granzyme-B-dependent manner in Jurkat cells.
Hantavirus Infections
Loss of cell membrane integrity in puumala hantavirus-infected patients correlates with levels of epithelial cell apoptosis and perforin.
Head and Neck Neoplasms
Increased PD-1(+) and TIM-3(+) TILs during Cetuximab Therapy Inversely Correlate with Response in Head and Neck Cancer Patients.
Heart Arrest
CTL-Derived Granzyme B Participates in Hippocampal Neuronal Apoptosis Induced by Cardiac Arrest and Resuscitation in Rats.
Hematologic Neoplasms
Genetic variants of human granzyme B predict transplant outcomes after HLA matched unrelated bone marrow transplantation for myeloid malignancies.
Hematologic Neoplasms
High expression of granzyme B in conventional CD4+ T cells is associated with increased relapses after allogeneic stem cells transplantation in patients with hematological malignancies.
Hematologic Neoplasms
[Synergistic Mechanism of Interferon alpha-1b, Interleukin-2 and Thalidomide for Immune Regulation in Patients with Acute Myeloid Leukemia].
Hepatitis
Differential expression of perforin and granzyme B in the liver of patients with chronic hepatitis C.
Hepatitis
Expression of Granzyme B in viral hepatitis in patients with ALPS.
Hepatitis
Immune-mediated liver injury of the cancer therapeutic antibody catumaxomab targeting EpCAM, CD3 and Fc? receptors.
Hepatitis
In situ expression of Granzyme B and Fas-ligand in the liver of viral hepatitis.
Hepatitis B
Myeloid-derived suppressor cells regulate immune response in patients with chronic hepatitis B virus infection through PD-1-induced IL-10.
Hepatitis B, Chronic
In situ expression of Granzyme B and Fas-ligand in the liver of viral hepatitis.
Hepatitis B, Chronic
NKG2D modulates aggravation of liver inflammation by activating NK cells in HBV infection.
Hepatitis B, Chronic
[Expression characteristics of some immune effector molecules in CD8+ T lymphocytes from patients with chronic hepatitis B]
Hepatitis C, Chronic
CD4(+) /CD25(+) T cells suppress autologous CD4(+) /CD25(-) lymphocytes and secrete granzyme B during acute and chronic hepatitis C.
Hepatitis C, Chronic
Differential expression of perforin and granzyme B in the liver of patients with chronic hepatitis C.
Hepatitis, Autoimmune
Perforin and granzyme B lytic protein expression during chronic viral and autoimmune hepatitis.
Hepatitis, Chronic
Perforin and granzyme B lytic protein expression during chronic viral and autoimmune hepatitis.
Herpes Genitalis
Granzyme B cleaves multiple HSV-1 and VZV gene products and VZV ORF4 inhibits Natural Killer cell dependent cytotoxicity.
Herpes Simplex
Kinetics of Primary and Memory Cytotoxic T Lymphocyte Responses to Herpes Simplex Virus 1 Infection: Granzyme B Mediated CTL Activity.
Herpes Simplex
The herpes simplex virus-1 Us3 protein kinase blocks CD8T cell lysis by preventing the cleavage of Bid by granzyme B.
Herpes Simplex
[The mechanism of stimforte action on herpesvirus infection.]
Herpes Zoster
Granzyme B cleaves multiple HSV-1 and VZV gene products and VZV ORF4 inhibits Natural Killer cell dependent cytotoxicity.
Histiocytic Necrotizing Lymphadenitis
Expression of Epstein-Barr virus and granzyme B in cytologic smears of histiocytic necrotizing lymphadenitis.
HIV Infections
Accessory cell dependent NK cell mediated PBMC IFN-gamma production is defective in HIV infection.
HIV Infections
Cytotoxic Capacity of SIV-Specific CD8(+) T Cells against Primary Autologous Targets Correlates with Immune Control in SIV-Infected Rhesus Macaques.
HIV Infections
Dissociated production of perforin, granzyme B, and IFN-gamma by HIV-specific CD8(+) cells in HIV infection.
HIV Infections
Granzyme B as a diagnostic marker of tuberculosis in patients with and without HIV coinfection.
HIV Infections
Gut-Associated Plasmacytoid Dendritic Cells Display an Immature Phenotype and Upregulated Granzyme B in Subjects with HIV/AIDS.
HIV Infections
Impaired plasmacytoid dendritic cell (PDC)-NK cell activity in viremic human immunodeficiency virus infection attributable to impairments in both PDC and NK cell function.
HIV Infections
Tc1 effector diversity shows dissociated expression of granzyme B and interferon-gamma in HIV infection.
HIV Infections
Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection.
Hodgkin Disease
Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system?
Hodgkin Disease
Granzyme B expression in Reed-Sternberg cells of Hodgkin's disease.
Hodgkin Disease
Hodgkin disease with subsequent transformation to CD30 positive non-hodgkin lymphoma in six patients.
Hodgkin Disease
Prognostic significance of activated cytotoxic T-lymphocytes in primary nodal diffuse large B-cell lymphomas.
Hydatidiform Mole
Age related cellular immune response against complete molar pregnancy.
Hydatidiform Mole
The granzyme B inhibitor, PI-9, is differentially expressed during placental development and up-regulated in hydatidiform moles.
Hypersensitivity
Boosters of a therapeutic HIV-1 vaccine induce divergent T cell responses related to regulatory mechanisms.
Hypersensitivity
Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells.
Hypersensitivity
Immunity Against Leishmania major Infection: Parasite-Specific Granzyme B Induction as a Correlate of Protection.
Hypertension
Epsin15 Homology Domains: Role in the Pathogenesis of Pulmonary Arterial Hypertension.
Hypertension
Granzyme B deficiency promotes osteoblastic differentiation and calcification of vascular smooth muscle cells in hypoxic pulmonary hypertension.
Hypertension
Intersectin-1s deficiency in pulmonary pathogenesis.
Hypertension, Pulmonary
Granzyme B deficiency promotes osteoblastic differentiation and calcification of vascular smooth muscle cells in hypoxic pulmonary hypertension.
Hypertension, Pulmonary
Selective cleavage of nucleolar autoantigen B23 by granzyme B in differentiated vascular smooth muscle cells: insights into the association of specific autoantibodies with distinct disease phenotypes.
Idiopathic Pulmonary Fibrosis
The perforin mediated apoptotic pathway in lung injury and fibrosis.
Infarction, Middle Cerebral Artery
Granzyme-b is involved in mediating post-ischemic neuronal death during focal cerebral ischemia in rat model.
Infections
A pro-survival role for the intracellular granzyme B inhibitor Serpinb9 in natural killer cells during poxvirus infection.
Infections
A role for the granzyme B inhibitor serine protease inhibitor 6 in CD8+ memory cell homeostasis.
Infections
Activation mechanisms of natural killer cells during influenza virus infection.
Infections
Activation-induced T helper cell death contributes to Th1/Th2 polarization following murine Schistosoma japonicum infection.
Infections
Adenovirus Serotype 5 Vaccination Results in Suboptimal CD4 T Helper 1 Responses in Mice.
Infections
An MHC class Ib-restricted CD8+ T cell response to lymphocytic choriomeningitis virus.
Infections
Analysis of the mucosal immune responses induced by single and trickle infections with the bovine abomasal nematode Ostertagia ostertagi.
Infections
Antigen-specific clonal expansion and cytolytic effector function of CD8+ T lymphocytes depend on the transcription factor Bcl11b.
Infections
Antigenic Re-Stimulation of Virus-Specific Memory CD8+ T Cells Requires Days of Lytic Protein Accumulation for Maximal Cytotoxic Capacity.
Infections
Asymptomatic Malaria Infection Is Maintained by a Balanced Pro- and Anti-inflammatory Response.
Infections
Blood monitoring of granzyme B and perforin expression after intestinal transplantation: considerations on clinical relevance.
Infections
Case report: T-cell responses during clearance of Andes virus from blood cells 2 months after severe hantavirus cardiopulmonary syndrome.
Infections
Caspase-dependent inhibition of mousepox replication by gzmB.
Infections
CD4(+) /CD25(+) T cells suppress autologous CD4(+) /CD25(-) lymphocytes and secrete granzyme B during acute and chronic hepatitis C.
Infections
CD8 T cell effector maturation in HIV-1-infected children.
Infections
Central memory CD8+ T cells become CD69+ tissue-residents during viral skin infection independent of CD62L-mediated lymph node surveillance.
Infections
Clinical and immunologic predictors of influenza illness among vaccinated older adults.
Infections
Collapse of Cytolytic Potential in SIV-Specific CD8+ T Cells Following Acute SIV Infection in Rhesus Macaques.
Infections
Complex Interplay Between MAZR and Runx3 Regulates the Generation of Cytotoxic T Lymphocyte and Memory T Cells.
Infections
Concomitant detection by flow cytometry of the intragranular antigen granzyme B and the intranuclear antigen Ki-67 in peripheral blood mononuclear cells from healthy individuals and patients with acute CMV infection after renal transplantation.
Infections
Connecting Effective Immune Response, Fluorescent Granzyme B-like Peptide, Specific Peptide Binding Patterns, Patients with Cancer and Viral Infection, in Remission, Clinical Significance, and Liquid Biopsy.
Infections
Control of lymphocytic choriomeningitis virus infection in granzyme B deficient mice.
Infections
Cutting Edge: Enhanced Clonal Burst Size Corrects an Otherwise Defective Memory Response by CD8+ Recent Thymic Emigrants.
Infections
Cytomegalovirus (CMV)-Specific Perforin and Granzyme B ELISPOT Assays Detect Reactivation of CMV Infection in Inflammatory Bowel Disease.
Infections
Cytotoxic Capacity of SIV-Specific CD8(+) T Cells against Primary Autologous Targets Correlates with Immune Control in SIV-Infected Rhesus Macaques.
Infections
Cytotoxic Epstein-Barr virus-positive large B cell lymphoma: a regulatory B cell-derived neoplasia?
Infections
Decrease of CD69 levels on TCR V?7.2(+)CD4(+) innate-like lymphocytes is associated with impaired cytotoxic functions in chronic hepatitis B virus-infected patients.
Infections
Dendritic cells, macrophages, NK and CD8(+) T lymphocytes play pivotal roles in controlling HSV-1 in the trigeminal ganglia by producing IL1-beta, iNOS and granzyme B.
Infections
Depletion but Activation of CD56dimCD16+?NK Cells in Acute Infection with Severe Fever with Thrombocytopenia Syndrome Virus.
Infections
Early cytokine and chemokine gene expression in lymph nodes of macaques infected with simian immunodeficiency virus is predictive of disease outcome and vaccine efficacy.
Infections
Effect of Broccoli Sprouts and Live Attenuated Influenza Virus on Peripheral Blood Natural Killer Cells: A Randomized, Double-Blind Study.
Infections
Elevated levels of serum perforin in chronic HIV-1 and acute SIV/SHIV infection.
Infections
Evaluation of cellular immunological responses in mono- and polymorphic clinical forms of Post Kala-Azar Dermal Leishmaniasis in India.
Infections
Ex vivo rectal explant model reveals potential opposing roles of Natural Killer cells and Marginal Zone-like B cells in HIV-1 infection.
Infections
Frequency, specificity, and sites of expansion of CD8+ T cells during primary pulmonary influenza virus infection.
Infections
Functional characterization of MHC class II-restricted CD8+CD4- and CD8-CD4- T cell responses to infection in CD4-/- mice.
Infections
Functionality of dengue virus specific memory T cell responses in individuals who were hospitalized or who had mild or subclinical dengue infection.
Infections
Genetic variants of human granzyme B predict transplant outcomes after HLA matched unrelated bone marrow transplantation for myeloid malignancies.
Infections
Granzyme B as a diagnostic marker of tuberculosis in patients with and without HIV coinfection.
Infections
Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells.
Infections
Granzyme B regulates antiviral CD8+ T cell responses.
Infections
Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes.
Infections
Hepatitis C virus alternative reading frame protein (ARFP): Production, features, and pathogenesis.
Infections
Higher expression of ferritin protects Chlamydia trachomatis infected HeLa 229 cells from reactive oxygen species mediated cell death.
Infections
HIV virions and HIV infection in vitro are unaffected by human granzymes A and B.
Infections
Host and donor immune responses contribute to antiviral effects of amotosalen-treated donor lymphocytes following early posttransplant cytomegalovirus infection.
Infections
IL-6 trans-signaling-dependent rapid development of cytotoxic CD8+ T cell function.
Infections
Immune events associated with high level protection against Schistosoma japonicum infection in pigs immunized with UV-attenuated cercariae.
Infections
Immunity Against Leishmania major Infection: Parasite-Specific Granzyme B Induction as a Correlate of Protection.
Infections
Immunization with Recombinant Adenoviral Vectors Expressing HCV Core or F Proteins Leads to T Cells with Reduced Effector Molecules Granzyme B and IFN-?: A Potential New Strategy for Immune Evasion in HCV Infection.
Infections
In vivo identification and characterization of CD4? cytotoxic T cells induced by virulent Brucella abortus infection.
Infections
Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells.
Infections
Kinetics of Primary and Memory Cytotoxic T Lymphocyte Responses to Herpes Simplex Virus 1 Infection: Granzyme B Mediated CTL Activity.
Infections
Lipidoid Nanoparticles Containing PD-L1 siRNA Delivered In Vivo Enter Kupffer Cells and Enhance NK and CD8(+) T Cell-mediated Hepatic Antiviral Immunity.
Infections
Longevity of T-cell memory following acute viral infection.
Infections
MAIT cells contribute to protection against lethal influenza infection in vivo.
Infections
Malaria-specific and nonspecific activation of CD8+ T cells during blood stage of Plasmodium berghei infection.
Infections
MAVS Deficiency Is Associated With a Reduced T Cell Response Upon Secondary RSV Infection in Mice.
Infections
miR-223: infection, inflammation and cancer.
Infections
Mucosal-associated invariant and ?? T cell subsets respond to initial Mycobacterium tuberculosis infection.
Infections
Murine cytomegalovirus replication in salivary glands is controlled by both perforin and granzymes during acute infection.
Infections
Natural killer cells in NOD.NK1.1 mice acquire cytolytic function during viral infection and provide protection against cytomegalovirus.
Infections
Perforin and granzyme B of cytotoxic T lymphocyte mediate apoptosis irrespective of Helicobacter pylori infection: possible act as a trigger of peptic ulcer formation.
Infections
Properties of CD4(+) T cells in human cytomegalovirus infection.
Infections
Quantitating the magnitude of the lymphocytic choriomeningitis virus-specific CD8 T-cell response: it is even bigger than we thought.
Infections
Rational Combination of Parvovirus H1 With CTLA-4 and PD-1 Checkpoint Inhibitors Dampens the Tumor Induced Immune Silencing.
Infections
Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection.
Infections
Rhesus Cytomegalovirus-Specific CD8+ Cytotoxic T Lymphocytes Do Not Become Functionally Exhausted in Chronic SIVmac239 Infection.
Infections
Role of PD-1 during effector CD8 T cell differentiation.
Infections
Stress-induced glucocorticoids at the earliest stages of herpes simplex virus-1 infection suppress subsequent antiviral immunity, implicating impaired dendritic cell function.
Infections
Strong impact of CD4+ Foxp3+ regulatory T cells and limited effect of T cell-derived IL-10 on pathogen clearance during Plasmodium yoelii infection.
Infections
T cell responses are better correlates of vaccine protection in the elderly.
Infections
T regulatory cells contribute to the attenuated primary CD8+ and CD4+ T cell responses to herpes simplex virus type 2 in neonatal mice.
Infections
TCR down-regulation boosts T-cell-mediated cytotoxicity and protection against poxvirus infections.
Infections
The innate antiviral immune system of the cat: Molecular tools for the measurement of its state of activation.
Infections
The unmet need in the elderly: How immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines.
Infections
Tissue-resident T cell derived cytokines eliminate herpes simplex virus-2 infected cells.
Infections
TLR3 Is a Negative Regulator of Immune Responses Against Paracoccidioides brasiliensis.
Infections
Transcriptional profiles in urine during acute rejection, bacteriuria, CMV infection and stable graft function after renal transplantation.
Infections
Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes.
Infections
Vaginal chlamydial clearance following primary or secondary infection in mice occurs independently of TNF-?.
Infections
Villus epithelial injury induced by infection with the nematode Nippostrongylus brasiliensis is associated with upregulation of granzyme B.
Infections
ZIKA virus infection causes persistent chorioretinal lesions.
Infections
[Expression characteristics of some immune effector molecules in CD8+ T lymphocytes from patients with chronic hepatitis B]
Infections
[Rasmussen encephalitis and non-herpetic acute limbic encephalitis]
Infectious Mononucleosis
B cell-derived circulating granzyme B is a feature of acute infectious mononucleosis.
Inflammatory Bowel Diseases
Cytomegalovirus (CMV)-Specific Perforin and Granzyme B ELISPOT Assays Detect Reactivation of CMV Infection in Inflammatory Bowel Disease.
Inflammatory Bowel Diseases
Differential levels of granzyme B, regulatory cytokines, and apoptosis in Crohn's disease and ulcerative colitis at first presentation.
Inflammatory Bowel Diseases
Plasma cells in the mucosa of patients with inflammatory bowel disease produce granzyme B and possess cytotoxic activities.
Influenza in Birds
Oral administration of an adenovirus vector encoding both an avian influenza A hemagglutinin and a TLR3 ligand induces antigen specific granzyme B and IFN-? T cell responses in humans.
Influenza, Human
A Randomized Controlled Study to Evaluate the Safety and Reactogenicity of a Novel rVLP-Based Plant Virus Nanoparticle Adjuvant Combined with Seasonal Trivalent Influenza Vaccine Following Single Immunization in Healthy Adults 18-50 Years of Age.
Influenza, Human
Apoptosis of lymphocytes and monocytes infected with influenza virus might be the mechanism of combating virus and causing secondary infection by influenza.
Influenza, Human
Assessment of markers of the cell-mediated immune response after influenza virus infection in frail older adults.
Influenza, Human
Cell-Mediated Immune Response to Influenza Using Ex Vivo Stimulation and Assays of Cytokine and Granzyme B Responses.
Influenza, Human
Cell-mediated immune response to influenza vaccination in lung transplant recipients.
Influenza, Human
Cellular Interferon Gamma and Granzyme B Responses to Cytomegalovirus-pp65 and Influenza N1 Are Positively Associated in Elderly.
Influenza, Human
Changes in Cell-Mediated Immunity (IFN-? and Granzyme B) Following Influenza Vaccination.
Influenza, Human
Characterisation of immune responses in healthy foals when a multivalent vaccine protocol was initiated at age 90 or 180 days.
Influenza, Human
Clinical and immunologic predictors of influenza illness among vaccinated older adults.
Influenza, Human
Cytomegalovirus Seropositivity Predicts a Decline in the T Cell But Not the Antibody Response to Influenza in Vaccinated Older Adults Independent of Type 2 Diabetes Status.
Influenza, Human
Effect of Broccoli Sprouts and Live Attenuated Influenza Virus on Peripheral Blood Natural Killer Cells: A Randomized, Double-Blind Study.
Influenza, Human
Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1.
Influenza, Human
Frequency, specificity, and sites of expansion of CD8+ T cells during primary pulmonary influenza virus infection.
Influenza, Human
Granzyme B ELISPOT assay to measure influenza-specific cellular immunity.
Influenza, Human
Granzyme B: a marker of risk for influenza in institutionalized older adults.
Influenza, Human
Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults.
Influenza, Human
Influenza vaccine-mediated protection in older adults: Impact of influenza infection, cytomegalovirus serostatus and vaccine dosage.
Influenza, Human
IRES-based co-expression of influenza virus conserved genes can promote synergistic antiviral effects both in vitro and in vivo.
Influenza, Human
Local blockade of epithelial PDL-1 in the airways enhances T cell function and viral clearance during influenza virus infection.
Influenza, Human
Lower GrB+ CD62Lhigh CD8 TCM effector lymphocyte response to influenza virus in older adults is associated with increased CD28null CD8 T lymphocytes.
Influenza, Human
MAIT cells contribute to protection against lethal influenza infection in vivo.
Influenza, Human
Moderate exercise improves antibody response to influenza immunization in older adults.
Influenza, Human
Overarching Immunodominance Patterns and Substantial Diversity in Specificity and Functionality in the Circulating Human Influenza A and B Virus-Specific CD4+ T-Cell Repertoire.
Influenza, Human
Properties of murine (CD8+)CD27- T cells.
Influenza, Human
T cell responses are better correlates of vaccine protection in the elderly.
Influenza, Human
The cell-mediated cytotoxic response to influenza vaccination using an assay for granzyme B activity.
Influenza, Human
The unmet need in the elderly: How immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines.
Keloid
Evaluation of the Role of Granzyme B in Exuberant Scar Pathogenesis: An Immunohistochemical Study.
Keratoacanthoma
A comparative study of granzyme B expression in keratoacanthoma and squamous cell carcinoma.
Keratoacanthoma
Possible key role of granzyme B in keratoacanthoma regression.
Kidney Failure, Chronic
Granzyme B as a novel factor involved in cardiovascular diseases.
Kidney Failure, Chronic
Plasma granzyme B as a predicting factor of coronary artery disease-Clinical significance in patients with chronic renal failure.
Laryngeal Neoplasms
Co-expression of perforin and granzyme B genes induces apoptosis and inhibits the tumorigenicity of laryngeal cancer cell line Hep-2.
Laryngeal Neoplasms
Expression, purification and anticancer analysis of GST-tagged human perforin and granzyme B proteins in human laryngeal cancer Hep-2 cells.
Latent Infection
Granzymes and caspase 3 play important roles in control of gammaherpesvirus latency.
Leishmaniasis, Cutaneous
Analysis of granzyme B activity as a surrogate marker of Leishmania-specific cell-mediated cytotoxicity in zoonotic cutaneous leishmaniasis.
Leishmaniasis, Cutaneous
Granzyme B Inhibition by Tofacitinib Blocks the Pathology Induced by CD8 T Cells in Cutaneous Leishmaniasis.
Leishmaniasis, Cutaneous
Granzyme B Produced by Natural Killer Cells Enhances Inflammatory Response and Contributes to the Immunopathology of Cutaneous Leishmaniasis.
Leishmaniasis, Visceral
The potential HLA Class I-restricted epitopes derived from LeIF and TSA of Leishmania donovani evoke anti-leishmania CD8+ T lymphocyte response.
Leptospirosis
Release of granzymes and chemokines in Thai patients with leptospirosis.
Leukemia
A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes.
Leukemia
Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors.
Leukemia
Epstein-Barr virus-associated proliferative disorder presenting as Hodgkin's lymphoma and developing as aggressive natural killer-cell leukemia 19 years later: A case report of composite lymphoma.
Leukemia
Ex vivo detection of primary leukemia cells resistant to granule cytotoxin-induced cell death: a rapid isolation method to study granzyme-B-mediated cell death.
Leukemia
Granule serine proteases are normal nuclear constituents of natural killer cells.
Leukemia
hIL-15-gene modified human natural killer cells (NKL-IL15) exhibit anti-human leukemia functions.
Leukemia
Immunotherapy for patients with acute myeloid leukemia using autologous dendritic cells generated from leukemic blasts.
Leukemia
Interaction of perforin and granzyme B and HTLV-1 viral factors is associated with Adult T cell Leukemia development.
Leukemia
LC3B upregulation by NANOG promotes immune resistance and stem-like property through hyperactivation of EGFR signaling in immune-refractory tumor cells.
Leukemia
M860, a Monoclonal Antibody against Human Lactoferrin, Enhances Tumoricidal Activity of Low Dosage Lactoferrin via Granzyme B Induction.
Leukemia
NK cell genotype and phenotype at diagnosis of acute lymphoblastic leukemia correlate with postinduction residual disease.
Leukemia
Polymethoxylated flavones potentiate the cytolytic activity of NK leukemia cell line KHYG-1 via enhanced expression of granzyme B.
Leukemia
Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin.
Leukemia
The granzyme B inhibitor PI-9 is differentially expressed in all main subtypes of pediatric acute lymphoblastic leukemias.
Leukemia
VEGF165b augments NK92 cytolytic activity against human K562 leukemia cells by upregulating the levels of perforin and granzyme B via the VEGR1-PLC pathway.
Leukemia
[Bone marrow-restricted involvement of T-cell granular lymphocyte leukemia]
Leukemia, Lymphocytic, Chronic, B-Cell
CD5(+) B cells from individuals with systemic lupus erythematosus express granzyme B.
Leukemia, Lymphoid
B-chronic lymphocytic leukemia cells and other B cells can produce granzyme B and gain cytotoxic potential after interleukin-21-based activation.
Leukemia, Lymphoid
Differentiation of human peripheral blood V{delta}1+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells.
Leukemia, Lymphoid
Distinct bone marrow findings in T-cell granular lymphocytic leukemia revealed by paraffin section immunoperoxidase stains for CD8, TIA-1, and granzyme B.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
The receptor for hyaluronic acid-mediated motility induces specific CD8+ T cell response in healthy donors and patients with chronic myeloid leukemia after allogeneic stem cell transplantation.
Leukemia, Myeloid, Acute
Granzyme B induction signalling pathway in acute myeloid leukemia cell lines stimulated by tumor necrosis factor alpha and Fas ligand.
Leukemia, T-Cell
Interaction of perforin and granzyme B and HTLV-1 viral factors is associated with Adult T cell Leukemia development.
Leukemia-Lymphoma, Adult T-Cell
Gastrointestinal T cell lymphoma: predominant cytotoxic phenotypes, including alpha/beta, gamma/delta T cell and natural killer cells.
Leukocytosis
Tumor-infiltrating cells as a prognostic factor in Hodgkin's lymphoma: a quantitative tissue microarray study in a large retrospective cohort of 267 patients.
Lichen Planus
Cytotoxic molecule expression and epithelial cell apoptosis in oral and cutaneous lichen planus.
Lichen Planus
Involvement of granzyme B and granulysin in the cytotoxic response in lichen planus.
Lichen Planus
Perforin and granzyme B expression in oral and cutaneous lichen planus - a comparative study.
Lichen Planus
Perforin and granzyme B involvement in oral lesions of lichen planus and chronic GVHD.
Lichen Planus
The role of granzyme B-expressing CD8-positive T cells in apoptosis of keratinocytes in lichen planus.
Lichen Planus
Type 1 interferon signature in the scalp lesions of alopecia areata.
Lichen Planus, Oral
Evaluation of PD-L1, PD-L2, PD-1 and cytotoxic immune response in oral lichen planus.
Lichen Planus, Oral
Perforin and granzyme B involvement in oral lesions of lichen planus and chronic GVHD.
Lichen Planus, Oral
[Expressions of Fas/FasL and granzyme B in oral lichen planus and their significance.]
Lichen Sclerosus et Atrophicus
Detection of perforin and granzyme B mRNA expressing cells in lichen sclerosus.
Liver Cirrhosis
Hepatic local micro-environmental immune status in hepatocellular carcinoma and cirrhotic tissues.
Liver Cirrhosis
Interferon-?-dependent immune responses contribute to the pathogenesis of sclerosing cholangitis in mice.
Liver Cirrhosis, Biliary
Contribution to antimitochondrial antibody production: cleavage of pyruvate dehydrogenase complex-E2 by apoptosis-related proteases.
Liver Diseases
Enhanced apoptosis relates to bile duct loss in primary biliary cirrhosis.
Lung Injury
Bile Acid aspiration associated with lung chemical profile linked to other biomarkers of injury after lung transplantation.
Lung Neoplasms
A Small Molecule Antagonist of PD-1/PD-L1 Interactions Acts as an Immune Checkpoint Inhibitor for NSCLC and Melanoma Immunotherapy.
Lung Neoplasms
Anisamide-Decorated pH-Sensitive Degradable Chimaeric Polymersomes Mediate Potent and Targeted Protein Delivery to Lung Cancer Cells.
Lung Neoplasms
Autoimmune response in lung cancer patients with neurological paraneoplastic syndromes.
Lung Neoplasms
Frequent T cell responses against immunogenic targets in lung cancer patients for targeted immunotherapy.
Lung Neoplasms
Granzyme B is correlated with clinical outcome after PD-1 blockade in patients with stage IV non-small-cell lung cancer.
Lung Neoplasms
Increased killer immunoglobulin-like receptor expression and functional defects in natural killer cells in lung cancer.
Lung Neoplasms
Increased proteinase inhibitor-9 (PI-9) and reduced granzyme B in lung cancer: Mechanism for immune evasion?
Lung Neoplasms
Involvement of granzyme B and perforin in suppressing nodal metastasis of cancer cells in breast and lung cancers.
Lung Neoplasms
Lung cancer is associated with decreased expression of perforin, granzyme B and interferon (IFN)-? by infiltrating lung tissue T cells, natural killer (NK)?T-like and NK cells.
Lung Neoplasms
Nicotine exhausts CD8+ T cells against tumor cells through increasing miR-629-5p to repress IL2RB-mediated granzyme B expression.
Lupus Erythematosus, Discoid
Immunohistochemical Expression of Granzyme B and Perforin in Discoid Lupus Erythematosus.
Lupus Erythematosus, Discoid
Type 1 interferon signature in the scalp lesions of alopecia areata.
Lupus Erythematosus, Systemic
Altered autoantigen structure in Sjögren's syndrome: implications for the pathogenesis of autoimmune tissue damage.
Lupus Erythematosus, Systemic
Apoptosis of the teratocarcinoma cell line Tera-1 leads to the cleavage of HERV-K10gag proteins by caspases and/or granzyme B.
Lupus Erythematosus, Systemic
CD5(+) B cells from individuals with systemic lupus erythematosus express granzyme B.
Lupus Erythematosus, Systemic
Granzyme B is dispensable for immunologic tolerance to self in a murine model of systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Increase in activated CD8+ T lymphocytes expressing perforin and granzyme B correlates with disease activity in patients with systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Soluble granzyme B and cytotoxic T lymphocyte activity in the pathogenesis of systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Systemic and local granzyme B levels are associated with disease activity, kidney damage and interferon signature in systemic lupus erythematosus.
Lupus Nephritis
IL-21 dependent Granzyme B production of B-cells is decreased in patients with lupus nephritis.
Lymphadenitis
Expression of Epstein-Barr virus and granzyme B in cytologic smears of histiocytic necrotizing lymphadenitis.
Lymphatic Metastasis
Absence of Granzyme B positive tumour-infiltrating lymphocytes in primary melanoma excisional biopsies is strongly associated with the presence of sentinel lymph node metastasis.
Lymphatic Metastasis
Correlation of P53 and Granzyme B expression in Oral Squamous Cell Carcinoma with Clinicopathologic Findings.
Lymphocytic Choriomeningitis
A role for the granzyme B inhibitor serine protease inhibitor 6 in CD8+ memory cell homeostasis.
Lymphocytic Choriomeningitis
Chronic HIV infection affects the expression of the 2 transcription factors required for CD8 T-cell differentiation into cytolytic effectors.
Lymphocytic Choriomeningitis
Control of lymphocytic choriomeningitis virus infection in granzyme B deficient mice.
Lymphocytic Choriomeningitis
Cutting edge: Persistently open chromatin at effector gene loci in resting memory CD8+ T cells independent of transcriptional status.
Lymphocytic Choriomeningitis
Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells.
Lymphocytosis
Idiopathic pure red cell aplasia: first report on CD8 positive lymphocytosis in bone marrow biopsy sections.
Lymphohistiocytosis, Hemophagocytic
Elevated Granzyme B in Cytotoxic Lymphocytes is a Signature of Immune Activation in Hemophagocytic Lymphohistiocytosis.
Lymphohistiocytosis, Hemophagocytic
Sequence analysis of the granulysin and granzyme B genes in familial hemophagocytic lymphohistiocytosis.
Lymphohistiocytosis, Hemophagocytic
[Expression of porforin and granzyme B in familial hemophagocytic lymphohistiocytosis].
Lymphoma
A case of systemic anaplastic large cell lymphoma with 'Hodgkin-like' appearance and skin involvement mimicking lymphomatoid papulosis.
Lymphoma
Anaplastic lymphoma kinase-positive anaplastic large cell lymphoma presenting as a bladder neoplasm.
Lymphoma
Angiodestruction and tissue necrosis of skin-involving CD56+ NK/T-cell lymphoma are influenced by expression of cell adhesion molecules and cytotoxic granule and apoptosis-related proteins.
Lymphoma
B-chronic lymphocytic leukemia cells and other B cells can produce granzyme B and gain cytotoxic potential after interleukin-21-based activation.
Lymphoma
Boosting CAR T-cell responses in lymphoma by simultaneous targeting of CD40/4-1BB using oncolytic viral gene therapy.
Lymphoma
Cases of cutaneous and nasal CD56 (NCAM)-positive lymphoma in Japan have differences in immunohistology, genotype, and etiology.
Lymphoma
CD30 expression in malignant vascular tumors and its diagnostic and clinical implications: a study of 146 cases.
Lymphoma
CD30 signals integrate expression of cytotoxic effector molecules, lymphocyte trafficking signals, and signals for proliferation and apoptosis.
Lymphoma
Comparative ultrastructural study of cytotoxic granules in nasal natural killer cell lymphoma, intestinal T-cell lymphoma, and anaplastic large cell lymphoma.
Lymphoma
Cutaneous intravascular anaplastic large cell lymphoma.
Lymphoma
Cutaneous Intravascular NK/T-cell lymphoma mimic panniculitis clinically, case report and literature brief review.
Lymphoma
Cytotoxic protein expression in natural killer cell lymphomas and in alpha beta and gamma delta peripheral T-cell lymphomas.
Lymphoma
Cytotoxic protein expression in non-Hodgkin's lymphomas and Hodgkin's disease.
Lymphoma
Differential expression of cytotoxic molecules and killer cell inhibitory receptors in CD8+ and CD56+ cutaneous lymphomas.
Lymphoma
Endogenous IL-21 restricts CD8+ T cell expansion and is not required for tumor immunity.
Lymphoma
Epstein-Barr virus in primary gastrointestinal T cell lymphomas. Association with gluten-sensitive enteropathy, pathological features, and immunophenotype.
Lymphoma
Epstein-Barr virus-positive T-cell lymphoma cells having chromosome 22q11.2 deletion: an autopsy report of DiGeorge syndrome.
Lymphoma
Expression of nm23-H1 is associated with poor prognosis in peripheral T-cell lymphoma.
Lymphoma
Expression of the granzyme B inhibitor PI9 predicts outcome in nasal NK/T-cell lymphoma: results of a Western series of 48 patients treated with first-line polychemotherapy within the Groupe d'Etude des Lymphomes de l'Adulte (GELA) trials.
Lymphoma
Extranodal NK/T-cell lymphoma, nasal type, arising in association with saline breast implant: expanding the spectrum of breast implant-associated lymphomas.
Lymphoma
Genetic variants of human granzyme B predict transplant outcomes after HLA matched unrelated bone marrow transplantation for myeloid malignancies.
Lymphoma
Granzyme B immunoreactivity in T/natural killer cell lymphomas.
Lymphoma
Granzyme B leakage-induced apoptosis is a crucial mechanism of cell death in nasal-type NK/T-cell lymphoma.
Lymphoma
Granzyme B-positive primary gastric T-cell lymphoma: gastric T-cell lymphoma with the possibility of extrathymic T cell origin.
Lymphoma
GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity.
Lymphoma
Hepatosplenic gamma-delta T-cell lymphoma associated with Epstein-Barr virus.
Lymphoma
Hepatosplenic gammadelta T-cell lymphoma: ultrastructural, immunophenotypic, and functional evidence for cytotoxic T lymphocyte differentiation.
Lymphoma
IL-21 Selectively Protects CD62L+ NKT Cells and Enhances Their Effector Functions for Adoptive Immunotherapy.
Lymphoma
Immunophenotypic characteristics and clinical relevance of CD56+ and CD56- extranodal nasal-type natural killer/T-cell lymphoma.
Lymphoma
Lymphomas are sensitive to perforin-dependent cytotoxic pathways despite expression of PI-9 and overexpression of bcl-2.
Lymphoma
MYD88 L265P mutation promoted malignant B cell resistance against T cell-mediated cytotoxicity via upregulating the IL-10/STAT3 cascade.
Lymphoma
Nasal NK/T cell lymphoma presenting as transverse myelopathy.
Lymphoma
Neutrophil-rich anaplastic large cell lymphoma presenting in the skin.
Lymphoma
Nodal cytotoxic lymphoma spectrum: a clinicopathologic study of 66 patients.
Lymphoma
Primary bony peripheral T-cell lymphoma mimicking nasal type NK/T-cell lymphoma: a case report.
Lymphoma
Primary central nervous system extranodal nasal-type natural killer/T-cell lymphoma with CD20 expression.
Lymphoma
Primary Cutaneous T-Cell Lymphomas Showing Gamma-Delta (??) Phenotype and Predominantly Epidermotropic Pattern are Clinicopathologically Distinct From Classic Primary Cutaneous ?? T-Cell Lymphomas.
Lymphoma
Primary extranodal nasal-type natural killer/T-cell lymphoma of the brain: a case report.
Lymphoma
Primary gastric apoptosis-rich T-cell lymphoma co-expressing CD4, CD8, and cytotoxic molecules.
Lymphoma
Primary gastric natural killer/T-cell lymphoma with diffuse CD30 expression and without CD56 expression: A case report.
Lymphoma
Primary hepatic Epstein-Barr virus-associated CD30-positive peripheral T-cell lymphoma of cytotoxic phenotype.
Lymphoma
Prognostic significance of activated cytotoxic T-lymphocytes in primary nodal diffuse large B-cell lymphomas.
Lymphoma
Sarcomatoid variant of ALK- anaplastic large cell lymphoma involving multiple lymph nodes and both lungs with production of proinflammatory cytokines: report of a case and review of literature.
Lymphoma
Superior Therapeutic Index in Lymphoma Therapy: CD30(+) CD34(+) Hematopoietic Stem Cells Resist a Chimeric Antigen Receptor T-cell Attack.
Lymphoma
The significance of granzyme B expression in patients with angiocentric lymphoma of the head and neck.
Lymphoma
Uniform expression of cytotoxic molecules in anaplastic large cell lymphoma of null/T cell phenotype and in cell lines derived from anaplastic large cell lymphoma.
Lymphoma
Updating targets for natural killer/T-cell lymphoma immunotherapy.
Lymphoma
[Angioimmunoblastic T-cell lymphoma associated with hemophagocytic syndrome at onset and relapse]
Lymphoma
[CD56- and CD4-positive non-Hodgkin's lymphoma of probable T-cell origin]
Lymphoma, B-Cell
Expression of cytotoxic molecules in intestinal T-cell lymphomas. The German Study Group on Intestinal Non-Hodgkin Lymphoma.
Lymphoma, B-Cell
Immune mediators in vitreous fluids from patients with vitreoretinal B-cell lymphoma.
Lymphoma, Large-Cell, Anaplastic
Anaplastic lymphoma kinase-positive anaplastic large cell lymphoma presenting as a bladder neoplasm.
Lymphoma, Large-Cell, Anaplastic
CD30 expression in malignant vascular tumors and its diagnostic and clinical implications: a study of 146 cases.
Lymphoma, Large-Cell, Anaplastic
Prognostic significance of activated cytotoxic T-lymphocytes in primary nodal diffuse large B-cell lymphomas.
Lymphoma, Non-Hodgkin
Evaluation of the cytotoxic response mediated by perforin and granzyme B in patients with non-Hodgkin lymphoma.
Lymphoma, Non-Hodgkin
Genetically re-engineered K562 cells significantly expand and functionally activate cord blood natural killer cells: Potential for adoptive cellular immunotherapy.
Lymphoma, Non-Hodgkin
Pregnancy-associated cytotoxic lymphoma: a report of 4 cases.
Lymphoma, Non-Hodgkin
Updating targets for natural killer/T-cell lymphoma immunotherapy.
Lymphoma, T-Cell
Classification of T-cell and NK-cell neoplasms based on the REAL classification.
Lymphoma, T-Cell
Comparative ultrastructural study of cytotoxic granules in nasal natural killer cell lymphoma, intestinal T-cell lymphoma, and anaplastic large cell lymphoma.
Lymphoma, T-Cell
Expression of cytotoxic molecules in intestinal T-cell lymphomas. The German Study Group on Intestinal Non-Hodgkin Lymphoma.
Lymphoma, T-Cell
Granzyme B immunoreactivity in T/natural killer cell lymphomas.
Lymphoma, T-Cell
Granzyme B-positive primary gastric T-cell lymphoma: gastric T-cell lymphoma with the possibility of extrathymic T cell origin.
Lymphoma, T-Cell
Histopathological features and immunophenotyping of canine transmural gastrointestinal lymphoma using full-thickness biopsy samples.
Lymphoma, T-Cell
Most primary cutaneous CD30-positive lymphoproliferative disorders have a CD4-positive cytotoxic T-cell phenotype.
Lymphoma, T-Cell
Nodal CD8 positive cytotoxic T-cell lymphoma: a distinct clinicopathological entity.
Lymphoma, T-Cell
Peripheral T-cell lymphomas with cytotoxic phenotype in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma.
Lymphoma, T-Cell, Cutaneous
Primary CD30-positive cutaneous T-cell lymphomas and lymphomatoid papulosis frequently express cytotoxic proteins.
Lymphoma, T-Cell, Peripheral
Clinicopathologic and prognostic significance of cytotoxic molecule expression in nodal peripheral T-cell lymphoma, unspecified.
Lymphoma, T-Cell, Peripheral
Peripheral T-Cell lymphoma manifested as gingival enlargement in a patient with chronic lymphocytic leukemia.
Lymphomatoid Papulosis
Most primary cutaneous CD30-positive lymphoproliferative disorders have a CD4-positive cytotoxic T-cell phenotype.
Lymphomatoid Papulosis
Primary CD30-positive cutaneous T-cell lymphomas and lymphomatoid papulosis frequently express cytotoxic proteins.
Lymphoproliferative Disorders
Enhanced tumorigenesis in HTLV-1 tax-transgenic mice deficient in interferon-gamma.
Malaria
Asymptomatic Malaria Infection Is Maintained by a Balanced Pro- and Anti-inflammatory Response.
Malaria
Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria.
Malaria
Memory CD73+IgM+ B cells protect against Plasmodium yoelii infection and express Granzyme B.
Malaria
Soluble markers of neutrophil, T-cell and monocyte activation are associated with disease severity and parasitemia in falciparum malaria.
Malaria, Cerebral
Granzyme B expression by CD8+ T cells is required for the development of experimental cerebral malaria.
Malaria, Falciparum
Cytotoxic T Cell-Derived Granzyme B Is Increased in Severe Plasmodium Falciparum Malaria.
Measles
Measles virus induces apoptosis in uninfected bystander T cells and leads to granzyme B and caspase activation in peripheral blood mononuclear cell cultures.
Melanoma
A Small Molecule Antagonist of PD-1/PD-L1 Interactions Acts as an Immune Checkpoint Inhibitor for NSCLC and Melanoma Immunotherapy.
Melanoma
Absence of Granzyme B positive tumour-infiltrating lymphocytes in primary melanoma excisional biopsies is strongly associated with the presence of sentinel lymph node metastasis.
Melanoma
Activated STAT5 promotes long-lived cytotoxic CD8+ T cells that induce regression of autochthonous melanoma.
Melanoma
Blockade of BAFF Receptor BR3 on T Cells Enhances Their Activation and Cytotoxicity.
Melanoma
Curcumin induces proapoptotic effects against human melanoma cells and modulates the cellular response to immunotherapeutic cytokines.
Melanoma
Cytolytic cells induce HMGB1 release from melanoma cell lines.
Melanoma
Defects in the acquisition of tumor-killing capability of CD8+ cytotoxic T cells in streptozotocin-induced diabetic mice.
Melanoma
Differential Clinicopathological Features in Spontaneous Regression of Melanomas and Melanocytic Naevi.
Melanoma
Differentiation of CD8+ T cells from tumor-invaded and tumor-free lymph nodes of melanoma patients: role of common gamma-chain cytokines.
Melanoma
Distinct patterns of cytolytic T-cell activation by different tumour cells revealed by Ca(2+) signalling and granule mobilization.
Melanoma
Enhanced Cancer Immunotherapy with Smad3-Silenced NK-92 Cells.
Melanoma
Granzyme B Degraded Type IV Collagen Products in Serum Identify Melanoma Patients Responding to Immune Checkpoint Blockade.
Melanoma
Granzyme B PET Imaging as a Predictive Biomarker of Immunotherapy Response.
Melanoma
HCA587 protein vaccine induces specific antitumor immunity mediated by CD4+ T-cells expressing granzyme B in a mouse model of melanoma.
Melanoma
IL-15-induced human DC efficiently prime melanoma-specific naive CD8+ T cells to differentiate into CTL.
Melanoma
Increased expression of perforin and granzyme B genes in patients with metastatic melanoma treated with recombinant interleukin-2.
Melanoma
Inhibitory Effect of Dihydroartemisinin on the Proliferation and Migration of Melanoma Cells and Experimental Lung Metastasis From Melanoma in Mice.
Melanoma
Isolated Limb Perfusion With Melphalan Triggers Immune Activation in Melanoma Patients.
Melanoma
LC3B upregulation by NANOG promotes immune resistance and stem-like property through hyperactivation of EGFR signaling in immune-refractory tumor cells.
Melanoma
Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse.
Melanoma
Multiple mechanisms underlie defective recognition of melanoma cells cultured in three-dimensional architectures by antigen-specific cytotoxic T lymphocytes.
Melanoma
Primary Tr1 cells from metastatic melanoma eliminate tumor-promoting macrophages through granzyme B- and perforin-dependent mechanisms.
Melanoma
Targeted Apoptosis Activation with GrB/scFvMEL Modulates Melanoma Growth, Metastatic Spread, Chemosensitivity, and Radiosensitivity.
Melanoma
The decreased susceptibility of metastatic melanoma cells to killing involves an alteration of CTL reactivity.
Melanoma
Upregulation of granzyme B and interferon-? mRNA in responding lesions by treatment with nivolumab for metastatic melanoma: a case report.
Melanoma, Experimental
B16 melanomas evade antitumor immunity by the loss of epitope presentation and the acquisition of tumor resistance to granzyme B.
Melanoma, Experimental
GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity.
Melanoma, Experimental
Natural Killer Cell Recruitment and Activation Are Regulated by CD47 Expression in the Tumor Microenvironment.
Melanoma, Experimental
Neem leaf glycoprotein is superior than Cisplatin and Sunitinib malate in restricting melanoma growth by normalization of tumor microenvironment.
Melanoma, Experimental
Silence STAT3 in the procancer niche
and activate CD8+ T cells to kill premetastatic myeloid intruders.
Meningococcal Infections
Elastase and granzymes during meningococcal disease in children: correlation to disease severity.
Mesothelioma
Foxp3+ Regulatory T Cell Depletion after Nonablative Oligofractionated Irradiation Boosts the Abscopal Effects in Murine Malignant Mesothelioma.
Mouth Diseases
GATA1/SP1 and miR-874 mediate enterovirus-71-induced apoptosis in a granzyme-B-dependent manner in Jurkat cells.
Mucocutaneous Lymph Node Syndrome
Increased Interleukin-35 suppresses peripheral CD14+ monocytes function in patients with Kawasaki disease.
Multiple Myeloma
Accessory Cells of the Microenvironment Protect Multiple Myeloma from T-Cell Cytotoxicity through Cell Adhesion-Mediated Immune Resistance.
Multiple Myeloma
CD44-targeted vesicles encapsulating granzyme B as artificial killer cells for potent inhibition of human multiple myeloma in mice.
Multiple Myeloma
Expression of granzyme B and perforin in multiple myeloma.
Multiple Sclerosis
A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity.
Multiple Sclerosis
Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients.
Multiple Sclerosis
Nonapoptotic and Extracellular Activity of Granzyme B Mediates Resistance to Regulatory T Cell (Treg) Suppression by HLA-DR-CD25hiCD127lo Tregs in Multiple Sclerosis and in Response to IL-6.
Multiple Sclerosis
Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1?.
Muscular Diseases
[Histological and molecular alterations in inflammatory myopathies].
Myasthenia Gravis
Granzyme B: Evidence for a role in the origin of myasthenia gravis.
Myelodysplastic Syndromes
Analysis of apoptosis regulatory genes expression in the bone marrow (BM) of adult de novo myelodysplastic syndromes (MDS).
Myelodysplastic Syndromes
Immune mediated autologous cytotoxicity against hematopoietic precursor cells in patients with myelodysplastic syndrome.
Myelodysplastic Syndromes
Increased TIM3+CD8+T cells in Myelodysplastic Syndrome patients displayed less perforin and granzyme B secretion and higher CD95 expression.
Myocardial Infarction
Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling.
Myocardial Infarction
Elevated levels of granzyme B correlated with miR-874-3p downregulation in patients with acute myocardial infarction.
Myocardial Infarction
Elevation of plasma granzyme B levels after acute myocardial infarction.
Myocardial Infarction
Granzyme B as a novel factor involved in cardiovascular diseases.
Myocardial Infarction
Plasma granzyme B in ST elevation myocardial infarction versus non-ST elevation acute coronary syndrome: comparisons with IL-18 and fractalkine.
Myocarditis
CD4+/CD8+ macrophages infiltrating at inflammatory sites: a population of monocytes/macrophages with a cytotoxic phenotype.
Myocarditis
Histopathologic Characterization of Myocarditis Associated With Immune Checkpoint Inhibitor Therapy.
Myocarditis
Imaging Granzyme B Activity Assesses Immune-Mediated Myocarditis.
Myositis
Expression of human IAP-like protein in skeletal muscle: a possible explanation for the rare incidence of muscle fiber apoptosis in T-cell mediated inflammatory myopathies.
Myositis
Polymyositis in solid organ transplant recipients receiving tacrolimus.
Myositis
Relationship between clinical course of nivolumab-related myositis and immune status in a patient with Hodgkin's lymphoma after allogeneic hematopoietic stem cell transplantation.
Myositis
The DNA mismatch repair enzyme PMS1 is a myositis-specific autoantigen.
Myositis, Inclusion Body
Expression of human IAP-like protein in skeletal muscle: a possible explanation for the rare incidence of muscle fiber apoptosis in T-cell mediated inflammatory myopathies.
Myxoma
Myxoma virus Serp2 is a weak inhibitor of granzyme B and interleukin-1beta-converting enzyme in vitro and unlike CrmA cannot block apoptosis in cowpox virus-infected cells.
Neoplasm Metastasis
Absence of Granzyme B positive tumour-infiltrating lymphocytes in primary melanoma excisional biopsies is strongly associated with the presence of sentinel lymph node metastasis.
Neoplasm Metastasis
An Oncolytic Adenovirus Targeting Transforming Growth Factor ? Inhibits Protumorigenic Signals and Produces Immune Activation: A Novel Approach to Enhance Anti-PD-1 and Anti-CTLA-4 Therapy.
Neoplasm Metastasis
Antitumor and radiosensitizing synergistic effects of apigenin and cryptotanshinone against solid Ehrlich carcinoma in female mice.
Neoplasm Metastasis
Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors.
Neoplasm Metastasis
Circulating PD-L1 is associated with T cell infiltration and predicts prognosis in patients with CRLM following hepatic resection.
Neoplasm Metastasis
Combination of immune checkpoint blockade with DNA cancer vaccine induces potent antitumor immunity against P815 mastocytoma.
Neoplasm Metastasis
Correlation of P53 and Granzyme B expression in Oral Squamous Cell Carcinoma with Clinicopathologic Findings.
Neoplasm Metastasis
Encapsulation of a CpG oligonucleotide in cationic liposomes enhances its local antitumor activity following pulmonary delivery in a murine model of metastatic lung cancer.
Neoplasm Metastasis
Experimental supporting data on the influence of platelet-derived factors of malignant pleural effusions on T cell effector functions and their relevance in predicting prognosis of lung adenocarcinoma patients with pleural metastasis.
Neoplasm Metastasis
Granzyme B gene polymorphisms, colorectal cancer risk, and metastasis.
Neoplasm Metastasis
Immunohistochemical investigations on the expression of programmed cell death ligand 1, human leukocyte antigens G and E, and granzyme B in intraoral mucoepidermoid carcinoma.
Neoplasm Metastasis
Involvement of granzyme B and perforin in suppressing nodal metastasis of cancer cells in breast and lung cancers.
Neoplasm Metastasis
Mechanisms involved in IL-15 superagonist enhancement of anti-PD-L1 therapy.
Neoplasm Metastasis
Natural killer cell-mediated ablation of metastatic liver tumors by hydrodynamic injection of IFNalpha gene to mice.
Neoplasm Metastasis
Primary Tumors Limit Metastasis Formation through Induction of IL15-Mediated Cross-Talk between Patrolling Monocytes and NK Cells.
Neoplasm Metastasis
Sequential metastases of colorectal cancer: Immunophenotypes and spatial distributions of infiltrating immune cells in relation to time and treatments.
Neoplasm Metastasis
Silence STAT3 in the procancer niche
and activate CD8+ T cells to kill premetastatic myeloid intruders.
Neoplasm Metastasis
Studies of hormonal regulation, phenotype plasticity, bone metastasis, and experimental therapeutics in androgen-repressed human prostate cancer (ARCaP) model.
Neoplasm Metastasis
Z-100, an Immunomodulatory Extract of Mycobacterium tuberculosis Strain Aoyama B, Prevents Spontaneous Lymphatic Metastasis of B16-BL6 Melanoma.
Neoplasm Metastasis
Z-100, an immunomodulatory extract of Mycobacterium tuberculosis strain Aoyama B, prevents spontaneous lymphatic metastasis of B16-BL6 melanoma.
Neoplasms
18F-FDG PET metabolic-to-morphological volume ratio predicts PD-L1 tumour expression and response to PD-1 blockade in non-small-cell lung cancer.
Neoplasms
?-Pinene Enhances the Anticancer Activity of Natural Killer Cells via ERK/AKT Pathway.
Neoplasms
A case of systemic anaplastic large cell lymphoma with 'Hodgkin-like' appearance and skin involvement mimicking lymphomatoid papulosis.
Neoplasms
A comparison of the local immune status between the primary and metastatic tumor in colorectal cancer: a retrospective study.
Neoplasms
A comprehensive analysis of immune infiltration in the tumor microenvironment of osteosarcoma.
Neoplasms
A dual-function epidermal growth factor receptor pathway substrate 8 (Eps8)-derived peptide exhibits a potent cytotoxic T lymphocyte-activating effect and a specific inhibitory activity.
Neoplasms
A Microfluidic Platform for Single Cell Fluorometric Granzyme B Profiling.
Neoplasms
A Negative Feedback Loop Between Autophagy and Immune Responses in Mycobacterium leprae Infection.
Neoplasms
A novel expression and purification system for the production of enzymatic and biologically active human granzyme B.
Neoplasms
A novel fully-human cytolytic fusion protein based on granzyme B shows in vitro cytotoxicity and ex vivo binding to solid tumors overexpressing the epidermal growth factor receptor.
Neoplasms
A novel Granzyme B nanoparticle delivery system simulates immune cell functions for suppression of solid tumors.
Neoplasms
A novel nude mice model of human extranodal nasal type NK/T-cell lymphoma.
Neoplasms
A novel therapeutic HBV vaccine candidate induces strong polyfunctional cytotoxic T cell responses in mice.
Neoplasms
A Novel Vaccine Targeting Glypican-3 as a Treatment for Hepatocellular Carcinoma.
Neoplasms
A Possible Role for Perforin and Granzyme B in Resveratrol Enhanced Radiosensitivity of Prostate Cancer.
Neoplasms
A substantial number of Rasmussen syndrome patients have increased IgG, CD4(+) T cells, TNFalpha, and Granzyme B in CSF.
Neoplasms
A versatile T cell-based assay to assess therapeutic antigen-specific PD-1-targeted approaches.
Neoplasms
Absence of CCR2 reduces spontaneous intestinal tumorigenesis in the ApcMin /+ mouse model.
Neoplasms
Absence of Granzyme B positive tumour-infiltrating lymphocytes in primary melanoma excisional biopsies is strongly associated with the presence of sentinel lymph node metastasis.
Neoplasms
Absence of host NF-?B p50 induces murine glioblastoma tumor regression, increases survival, and decreases T-cell induction of tumor-associated macrophage M2 polarization.
Neoplasms
Activated cytotoxic T cells as prognostic marker in Hodgkin's disease.
Neoplasms
Activated STAT5 promotes long-lived cytotoxic CD8+ T cells that induce regression of autochthonous melanoma.
Neoplasms
Activation of regulatory T cells instigates functional down-regulation of cytotoxic T lymphocytes in human breast cancer.
Neoplasms
Adenosine acts through an A3 receptor to prevent the induction of murine anti-CD3-activated killer T cells.
Neoplasms
Adenosine receptor 2A blockade increases the efficacy of anti-PD-1 through enhanced anti-tumor T cell responses.
Neoplasms
Alogliptin abates memory injuries of hepatic encephalopathy induced by acute paracetamol intoxication via switching-off autophagy-related apoptosis.
Neoplasms
Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice.
Neoplasms
Altered CD8+ T-Cell Lymphocyte Function and TC1 Cell Stemness Contribute to Enhanced Malignant Tumor Properties in Murine Models of Sleep Apnea.
Neoplasms
An extraordinary T/NK lymphoma, nasal type, occurring primarily in the prostate gland with unusual CD30 positivity: case report and review of the literature.
Neoplasms
An Oncolytic Adenovirus Encoding Decorin and Granulocyte Macrophage Colony Stimulating Factor Inhibits Tumor Growth in a Colorectal Tumor Model by Targeting Pro-Tumorigenic Signals and via Immune Activation.
Neoplasms
An Oncolytic Adenovirus Targeting Transforming Growth Factor ? Inhibits Protumorigenic Signals and Produces Immune Activation: A Novel Approach to Enhance Anti-PD-1 and Anti-CTLA-4 Therapy.
Neoplasms
An ultrastructural study of cutaneous panniculitis-like T-cell lymphoma: cytoplasmic granules and active cellular and cell-to-matrix interaction mimic cytotoxic T-cells.
Neoplasms
Anaplastic large cell lymphoma--a rare disorder in southern Taiwan.
Neoplasms
Anaplastic large cell lymphomas presented as bone lesions: a clinicopathologic study of six cases and review of the literature.
Neoplasms
Andrographolide potentiates PD-1 blockade immunotherapy by inhibiting COX2-mediated PGE2 release.
Neoplasms
Anti-leukemia effect of ex vivo expanded DNT cells from AML patients: a potential novel autologous T-cell adoptive immunotherapy.
Neoplasms
Antitumor and radiosensitizing synergistic effects of apigenin and cryptotanshinone against solid Ehrlich carcinoma in female mice.
Neoplasms
Apoptosis in mycobacterium tuberculosis infection in mice exhibiting varied immunopathology.
Neoplasms
Apoptosis pathways as promising targets for skin cancer therapy.
Neoplasms
Application of Sodium Selenite in the Prevention and Treatment of Cancers.
Neoplasms
Application of the granzyme B ELISPOT assay for monitoring cancer vaccine trials.
Neoplasms
Aptamer-T Cell Targeted Therapy for Tumor Treatment Using Sugar Metabolism and Click Chemistry.
Neoplasms
Aqueous immune mediators in malignant uveal melanomas in comparison to benign pigmented intraocular tumors.
Neoplasms
Assessment of IFN-? and granzyme-B production by in "sitro" technology.
Neoplasms
Asymptomatic Malaria Infection Is Maintained by a Balanced Pro- and Anti-inflammatory Response.
Neoplasms
B-chronic lymphocytic leukemia cells and other B cells can produce granzyme B and gain cytotoxic potential after interleukin-21-based activation.
Neoplasms
B16 melanomas evade antitumor immunity by the loss of epitope presentation and the acquisition of tumor resistance to granzyme B.
Neoplasms
B7-H5 blockade enhances CD8+ T-cell-mediated antitumor immunity in colorectal cancer.
Neoplasms
B7-H6 as an efficient target for T cell-induced cytotoxicity in haematologic malignant cells.
Neoplasms
Bioresponsive functional nanogels as an emerging platform for cancer therapy.
Neoplasms
Bispecific anti-PD-1/LAG-3 antibodies for treatment of advanced or metastatic solid tumors: a patent evaluation of US2018326054.
Neoplasms
Bispecific Antibody PD-L1 x CD3 Boosts the Anti-Tumor Potency of the Expanded V?2V?2 T Cells.
Neoplasms
Blastic natural killer cell lymphoma/leukaemia in a cat.
Neoplasms
Blockade of surface-bound TGF-? on regulatory T cells abrogates suppression of effector T cell function in the tumor microenvironment.
Neoplasms
Blockade of transforming growth factor ?2 by anti-sense oligonucleotide improves immunotherapeutic potential of IL-2 against melanoma in a humanized mouse model.
Neoplasms
Blocking IL-1? reverses the immunosuppression in mouse breast cancer and synergizes with anti-PD-1 for tumor abrogation.
Neoplasms
Bortezomib enhances expression of effector molecules in anti-tumor CD8+ T lymphocytes by promoting Notch-nuclear factor-?B crosstalk.
Neoplasms
BRAF targeting sensitizes resistant melanoma to cytotoxic T cells.
Neoplasms
Bronchiolitis obliterans syndrome is associated with increased senescent lymphocytes in the small airways.
Neoplasms
Canine intravascular lymphoma with overt leukemia.
Neoplasms
Case Report: Simultaneous Hyperprogression and Fulminant Myocarditis in a Patient With Advanced Melanoma Following Treatment With Immune Checkpoint Inhibitor Therapy.
Neoplasms
Catenin Alpha-2 Mutation Changes the Immune Microenvironment in Lung Adenocarcinoma Patients Receiving Immune Checkpoint Inhibitors.
Neoplasms
Cbl-b Is Upregulated and Plays a Negative Role in Activated Human NK Cells.
Neoplasms
CCL21 and IFN? recruit and activate tumor specific T cells in 3D scaffold model of breast cancer.
Neoplasms
CD26-mediated co-stimulation in human CD8(+) T cells provokes effector function via pro-inflammatory cytokine production.
Neoplasms
CD4+ T-Cell Help in the Tumor Milieu Is Required for Recruitment and Cytolytic Function of CD8+ T Lymphocytes.
Neoplasms
CD47 in the tumor microenvironment limits cooperation between antitumor T-cell immunity and radiotherapy.
Neoplasms
CD4? T cells expressing latency-associated peptide and Foxp3 are an activated subgroup of regulatory T cells enriched in patients with colorectal cancer.
Neoplasms
CD8+HLA-DR+ T cells are increased in patients with severe aplastic anemia.
Neoplasms
CDK8-Mediated STAT1-S727 Phosphorylation Restrains NK Cell Cytotoxicity and Tumor Surveillance.
Neoplasms
Celiac Disease-Related Inflammation Is Marked by Reduction of Nkp44/Nkp46-Double Positive Natural Killer Cells.
Neoplasms
Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B.
Neoplasms
Cell-mediated lysis of autologous platelets in chronic idiopathic thrombocytopenic purpura.
Neoplasms
Cellular participation in delayed xenograft rejection of hCD55 transgenic pig hearts by baboons.
Neoplasms
Ceria nanoparticles promoted the cytotoxic activity of CD8+ T cells by activating NF-?B signaling.
Neoplasms
Characterization of immunoreactivity with whole-slide imaging and digital analysis in high-grade serous ovarian cancer.
Neoplasms
Characterization of natural killer and natural killer-like T cells derived from ex vivo expanded and activated cord blood mononuclear cells: implications for adoptive cellular immunotherapy.
Neoplasms
Characterization of the ectromelia virus serpin, SPI-2.
Neoplasms
Characterization of tumour-infiltrating lymphocytes and apoptosis in colitis-associated neoplasia: comparison with sporadic colorectal cancer.
Neoplasms
Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model.
Neoplasms
CIGB-258, a peptide derived from human heat-shock protein 60, decreases hyperinflammation in COVID-19 patients.
Neoplasms
Clinical and pathological spectrum of CD8-positive cutaneous T-cell lymphomas.
Neoplasms
Clinical outcomes and genetic expression profile in human liver graft dysfunction during ischemia/reperfusion injury.
Neoplasms
Clinical significance of regulatory T cells and CD8+ effector populations in patients with human endometrial carcinoma.
Neoplasms
Co-expression of perforin and granzyme B genes induces apoptosis and inhibits the tumorigenicity of laryngeal cancer cell line Hep-2.
Neoplasms
Combination of immune checkpoint blockade with DNA cancer vaccine induces potent antitumor immunity against P815 mastocytoma.
Neoplasms
Combined Modality Management of Sinonasal Anaplastic Lymphoma Kinase Negative Anaplastic Large Cell Lymphoma in a Geriatric Patient-Report of a Rare Case.
Neoplasms
Comparable polyfunctionality of ectromelia virus- and vaccinia virus-specific murine T cells despite markedly different in vivo replication and pathogenicity.
Neoplasms
Comparing high-throughput methods to measure NK cell-mediated antibody dependent cellular cytotoxicity during HIV-infection.
Neoplasms
Comparison of six cell penetrating peptides with different properties for in vitro and in vivo delivery of HPV16 E7 antigen in therapeutic vaccines.
Neoplasms
Comprehensive analysis of marker gene detection and computed tomography for the diagnosis of human lung cancer.
Neoplasms
Connecting Effective Immune Response, Fluorescent Granzyme B-like Peptide, Specific Peptide Binding Patterns, Patients with Cancer and Viral Infection, in Remission, Clinical Significance, and Liquid Biopsy.
Neoplasms
Contrasting Prognostic Effects of Tumor-Infiltrating Lymphocyte Density in Cardia and Non-cardia Gastric Adenocarcinomas.
Neoplasms
Control of lytic function by mitogen-activated protein kinase/extracellular regulatory kinase 2 (ERK2) in a human natural killer cell line: identification of perforin and granzyme B mobilization by functional ERK2.
Neoplasms
Cooperative Immune-Mediated Mechanisms of the HDAC Inhibitor Entinostat, an IL15 Superagonist, and a Cancer Vaccine Effectively Synergize as a Novel Cancer Therapy.
Neoplasms
Core2 O-glycan-expressing prostate cancer cells are resistant to NK cell immunity.
Neoplasms
Correlation Patterns Among B7 Family Ligands and Tryptophan Degrading Enzymes in Hepatocellular Carcinoma.
Neoplasms
CTLA-4 Blockade Expands Infiltrating T Cells and Inhibits Cancer Cell Repopulation during the Intervals of Chemotherapy in Murine Mesothelioma.
Neoplasms
Cutaneous adverse drug reaction in patients with epilepsy after acute encephalitis.
Neoplasms
Cutaneous Peripheral T-Cell Lymphoma of Cytotoxic Phenotype Mimicking Extranodal NK/T-Cell Lymphoma.
Neoplasms
CXCR5(+)CD8(+) T cells infiltrate the colorectal tumors and nearby lymph nodes, and are associated with enhanced IgG response in B cells.
Neoplasms
Cytokine and chemokine expression in tumors of mice receiving systemic therapy with IL-12.
Neoplasms
Cytotoxic markers and frequency predict functional capacity of natural killer cells infiltrating renal cell carcinoma.
Neoplasms
Cytotoxic phenotype of tumor infiltrating lymphocytes in medullary carcinoma of the breast.
Neoplasms
Cytotoxic protein expression in natural killer cell lymphomas and in alpha beta and gamma delta peripheral T-cell lymphomas.
Neoplasms
Cytotoxic protein expression in non-Hodgkin's lymphomas and Hodgkin's disease.
Neoplasms
Cytotoxic T Cells and Granzyme B Associated with Improved Colorectal Cancer Survival in a Prospective Cohort of Older Women.
Neoplasms
Cytotoxic T lymphocyte-dependent tumor growth inhibition by a vascular endothelial growth factor-superantigen conjugate.
Neoplasms
Defective gammadelta T-cell function and granzyme B gene polymorphism in a cohort of newly diagnosed breast cancer patients.
Neoplasms
Defects in the acquisition of tumor-killing capability of CD8+ cytotoxic T cells in streptozotocin-induced diabetic mice.
Neoplasms
Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73- Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes.
Neoplasms
Dendritic Cell Vaccination in Metastatic Melanoma Turns "Non-T Cell Inflamed" Into "T-Cell Inflamed" Tumors.
Neoplasms
Dendritic cell-based vaccination: powerful resources of immature dendritic cells against pancreatic adenocarcinoma.
Neoplasms
Dendritic cells transfected with heat-shock protein 70 messenger RNA for patients with hepatitis C virus-related hepatocellular carcinoma: a phase 1 dose escalation clinical trial.
Neoplasms
Design and Discovery of Natural Cyclopeptide Skeleton Based Programmed Death Ligand 1 Inhibitor as Immune Modulator for Cancer Therapy.
Neoplasms
Design of Artificial Immunogens Containing Melanoma-associated T-cell Epitopes.
Neoplasms
Detection of binding of a synthetic granzyme B-like peptide fluorescent conjugate within platelet-like structures in cancer-related peripheral blood specimens and tissue sections.
Neoplasms
Detection of Cancer Cell Death Mediated by a Synthetic Granzyme B-like Peptide Fluorescent Conjugate and the same Peptide Binding in Bacteria.
Neoplasms
Development of a human immuno-oncology therapeutic agent targeting HER2: targeted delivery of granzyme B.
Neoplasms
Development of Facile and Versatile Platinum Drug Delivering Silicasome Nanocarriers for Efficient Pancreatic Cancer Chemo-Immunotherapy.
Neoplasms
Differential Effect of MyD88 Signal in Donor T Cells on Graft-versus-Leukemia Effect and Graft-versus-Host Disease after Experimental Allogeneic Stem Cell Transplantation.
Neoplasms
Differential Impact of T-bet and IFN? on Pancreatic Islet Allograft Rejection.
Neoplasms
Differential up-regulation of cytosolic and membrane-bound heat shock protein 70 in tumor cells by anti-inflammatory drugs.
Neoplasms
Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy.
Neoplasms
Discovery of secondary sulphonamides as IDO1 inhibitors with potent antitumour effects in vivo.
Neoplasms
Disparate distribution of 16 candidate single nucleotide polymorphisms among racial and ethnic groups of pediatric heart transplant patients.
Neoplasms
Distinct expression of perforin and granzyme B in lip and oral cavity squamous cell carcinoma.
Neoplasms
Distinct functions of CXCR3+ and CCR4+CD4+ T-cells accumulated in human tuberculosis pleural fluid.
Neoplasms
Distinct patterns of cytolytic T-cell activation by different tumour cells revealed by Ca(2+) signalling and granule mobilization.
Neoplasms
DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells.
Neoplasms
DNAX-activating protein 10 co-stimulation enhances the anti-tumor efficacy of chimeric antigen receptor T cells.
Neoplasms
Donor treatment with carbon monoxide can yield islet allograft survival and tolerance.
Neoplasms
Early Tumor-Infiltrating Dendritic Cells Change their Characteristics Drastically in Association with Murine Melanoma Progression.
Neoplasms
EBAG9 modulates host immune defense against tumor formation and metastasis by regulating cytotoxic activity of T lymphocytes.
Neoplasms
Echinococcus multilocularis induces surface high expression of inhibitory killer immunoglobulin-like receptor on natural killer cells.
Neoplasms
Effects of Beta-Blockers on Melanoma Microenvironment and Disease Survival in Human.
Neoplasms
Effects of Combinations of Goat Milk and Oligosaccharides on Altering the Microbiota, Immune Responses, and Short Chain Fatty Acid Levels in the Small Intestines of Mice.
Neoplasms
EGFR and CD44 Dual-Targeted Multifunctional Hyaluronic Acid Nanogels Boost Protein Delivery to Ovarian and Breast Cancers In Vitro and In Vivo.
Neoplasms
EGFR-targeted granzyme B expressed in NK cells enhances natural cytotoxicity and mediates specific killing of tumor cells.
Neoplasms
Elevated interleukin-27 enhances the polarization of Th1/Tc1 cells and the production of proinflammatory cytokines in primary immune thrombocytopenia.
Neoplasms
Elevated serum granulysin and its clinical relevance in mature NK-cell neoplasms.
Neoplasms
Elevation of plasma granzyme B levels after acute myocardial infarction.
Neoplasms
Endothelial cell apoptosis in severe drug-induced bullous eruptions.
Neoplasms
Enhanced Antitumor Response to Immune Checkpoint Blockade Exerted by Cisplatin-Induced Mutagenesis in a Murine Melanoma Model.
Neoplasms
Enhanced Cancer Immunotherapy with Smad3-Silenced NK-92 Cells.
Neoplasms
Enhancement of immunogenicity of a therapeutic cervical cancer DNA-based vaccine by co-application of sequence-optimized genetic adjuvants.
Neoplasms
Enhancing Dendritic Cell-based Immunotherapy with IL-2/Monoclonal Antibody Complexes for Control of Established Tumors.
Neoplasms
Enhancing direct cytotoxicity and response to immune checkpoint blockade following ionizing radiation with Wee1 kinase inhibition.
Neoplasms
Enteropathy-associated T-cell lymphomas have a cytotoxic T-cell phenotype.
Neoplasms
Epirubicin pretreatment enhances NK cell-mediated cytotoxicity against breast cancer cells in vitro.
Neoplasms
Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease.
Neoplasms
Epstein-Barr virus in primary gastrointestinal T cell lymphomas. Association with gluten-sensitive enteropathy, pathological features, and immunophenotype.
Neoplasms
Epstein-Barr virus-associated natural killer/T-cell lymphomas.
Neoplasms
Epstein-Barr Virus-Induced Gene 3 (EBI3) Blocking Leads to Induce Antitumor Cytotoxic T Lymphocyte Response and Suppress Tumor Growth in Colorectal Cancer by Bidirectional Reciprocal-Regulation STAT3 Signaling Pathway.
Neoplasms
Erratum to: 'Expression of granzyme B sensitizes ALK+ ALCL tumour cells to apoptosis-inducing drugs'.
Neoplasms
Etanercept reduces the serum levels of macrophage chemotactic protein-1 in patients with rheumatoid arthritis.
Neoplasms
Evaluation of expression of common genes in the intestine and peripheral blood mononuclear cells (PBMC) associated with celiac disease.
Neoplasms
Evaluation of serum-free media formulations in feeder cell-stimulated expansion of natural killer cells.
Neoplasms
Ex vivo characterization of human CD8+ T subsets with distinct replicative history and partial effector functions.
Neoplasms
Ex vivo expansion and Th1/Tc1 maturation of umbilical cord blood T cells by CD3/CD28 costimulation.
Neoplasms
Ex Vivo Interleukin-12-Priming During CD8(+) T Cell Activation Dramatically Improves Adoptive T Cell Transfer Antitumor Efficacy in a Lymphodepleted Host.
Neoplasms
Ex vivo simulation of leukocyte function: Stimulation of specific subset of leukocytes in whole blood followed by the measurement of function-associated mRNAs.
Neoplasms
Examining Immunotherapy Response Using Multiple Radiotracers.
Neoplasms
Expression of a Broad Array of Negative Costimulatory Molecules and Blimp-1 in T Cells following Priming by HIV-1 Pulsed Dendritic Cells.
Neoplasms
Expression of cellular FLICE inhibitory protein, caspase-8, and protease inhibitor-9 in Ewing sarcoma and implications for susceptibility to cytotoxic pathways.
Neoplasms
Expression of cytotoxic molecules in intestinal T-cell lymphomas. The German Study Group on Intestinal Non-Hodgkin Lymphoma.
Neoplasms
Expression of endogenous granzyme B in a subset of human primary breast carcinomas.
Neoplasms
Expression of FOXP3, CD14, and ARG1 in Neuroblastoma Tumor Tissue from High-Risk Patients Predicts Event-Free and Overall Survival.
Neoplasms
Expression of granzyme B sensitizes ALK+ ALCL tumour cells to apoptosis-inducing drugs.
Neoplasms
Expression of Leukotriene B4 Receptor-1 on CD8+ T Cells Is Required for Their Migration into Tumors To Elicit Effective Antitumor Immunity.
Neoplasms
Expression of MAGE tumour-associated antigens is inversely correlated with tumour differentiation in invasive ductal breast cancers: an immunohistochemical study.
Neoplasms
Expression of the apoptosis inhibitor protease inhibitor 9 predicts clinical outcome in vaccinated patients with stage III and IV melanoma.
Neoplasms
Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: a novel protective mechanism for tumor cells to circumvent the immune system?
Neoplasms
Expression pattern of immune suppressive cytokines and growth factors in oesophageal adenocarcinoma reveal a tumour immune escape-promoting microenvironment.
Neoplasms
Expression, purification and anticancer analysis of GST-tagged human perforin and granzyme B proteins in human laryngeal cancer Hep-2 cells.
Neoplasms
Extranodal cytotoxic T-cell lymphoma in a patient with X-linked agammaglobulinaemia.
Neoplasms
Extranodal nasal-type natural killer/T-cell lymphoma of the skin: a clinicopathologic study of 16 cases in China.
Neoplasms
Extranodal natural killer/T-cell lymphoma, nasal-type.
Neoplasms
Extranodal NK/T-cell lymphoma in Tunisia: clinicopathological features, immunophenotype and EBV infection.
Neoplasms
Extranodal NK/T-cell lymphoma, nasal type of the uterine cervix: A case report.
Neoplasms
Factors associated with severe granulomatous pneumonia in Mycobacterium tuberculosis-infected mice vaccinated therapeutically with hsp65 DNA.
Neoplasms
Foxp3+ Regulatory T Cell Depletion after Nonablative Oligofractionated Irradiation Boosts the Abscopal Effects in Murine Malignant Mesothelioma.
Neoplasms
Frequent T cell responses against immunogenic targets in lung cancer patients for targeted immunotherapy.
Neoplasms
Functional activity of natural killer cells in biological fluids in patients with colorectal and ovarian cancers.
Neoplasms
Functional CD8+ T cells infiltrate into nonsmall cell lung carcinoma.
Neoplasms
Functional Characterization of BK Virus-Specific CD4(+) T Cells with Cytotoxic Potential in Seropositive Adults.
Neoplasms
Functional role of phosphatidylinositol 3-kinase in direct tumor lysis by human natural killer cells.
Neoplasms
Gadd45b and Gadd45g are important for anti-tumor immune responses.
Neoplasms
Gap junction intercellular communications regulate NK cell activation and modulate NK cytotoxic capacity.
Neoplasms
Gene expression analysis of tumor infiltrating lymphocyte markers in endometrial cancers indicates no significant increases in those cases with microsatellite instability.
Neoplasms
Generation of tumor-specific T lymphocytes using dendritic cell/tumor fusions and anti-CD3/CD28.
Neoplasms
Genetic variants of human granzyme B predict transplant outcomes after HLA matched unrelated bone marrow transplantation for myeloid malignancies.
Neoplasms
Genetically Induced Tumors in the Oncopig Model Invoke an Antitumor Immune Response Dominated by Cytotoxic CD8?+ T Cells and Differentiated ?? T Cells Alongside a Regulatory Response Mediated by FOXP3+ T Cells and Immunoregulatory Molecules.
Neoplasms
GITR ligation enhances functionality of tumor-infiltrating T cells in hepatocellular carcinoma.
Neoplasms
Glial injury in neurotoxicity after pediatric CD19-directed chimeric antigen receptor T cell therapy.
Neoplasms
Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance.
Neoplasms
Granzyme B and perforin produced by SEC2 mutant-activated human CD4+ T cells and CD8+ T cells induce apoptosis of K562 leukemic cells by the mitochondrial apoptotic pathway.
Neoplasms
Granzyme B as a prognostic marker of cervical intraepithelial neoplasia.
Neoplasms
Granzyme B Contributes to the Optimal Graft-Versus-Tumor Effect Mediated by Conventional CD4
Neoplasms
Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia.
Neoplasms
Granzyme B Expression Is Enhanced in Human Monocytes by TLR8 Agonists and Contributes to Antibody-Dependent Cellular Cytotoxicity.
Neoplasms
Granzyme B Functionalized Nanoparticles Targeting Membrane Hsp70-Positive Tumors for Multimodal Cancer Theranostics.
Neoplasms
Granzyme B gene polymorphisms, colorectal cancer risk, and metastasis.
Neoplasms
Granzyme B immunoreactivity in T/natural killer cell lymphomas.
Neoplasms
Granzyme B in Inflammatory Diseases: Apoptosis, Inflammation, Extracellular Matrix Remodeling, Epithelial-to-Mesenchymal Transition and Fibrosis.
Neoplasms
Granzyme B in peripheral blood mononuclear cells as a measure of cell-mediated immune response in paraneoplastic neurological syndromes and malignancy.
Neoplasms
Granzyme B induction signalling pathway in acute myeloid leukemia cell lines stimulated by tumor necrosis factor alpha and Fas ligand.
Neoplasms
Granzyme B is expressed in urothelial carcinoma and promotes cancer cell invasion.
Neoplasms
Granzyme B leakage-induced apoptosis is a crucial mechanism of cell death in nasal-type NK/T-cell lymphoma.
Neoplasms
Granzyme B nanoreporter for early monitoring of tumor response to immunotherapy.
Neoplasms
Granzyme B PET Imaging as a Predictive Biomarker of Immunotherapy Response.
Neoplasms
Granzyme B PET Imaging of Combined Chemotherapy and Immune Checkpoint Inhibitor Therapy in Colon Cancer.
Neoplasms
Granzyme B PET imaging of immune-mediated tumor killing as a tool for understanding immunotherapy response.
Neoplasms
Granzyme B Produced by Natural Killer Cells Enhances Inflammatory Response and Contributes to the Immunopathology of Cutaneous Leishmaniasis.
Neoplasms
Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells.
Neoplasms
Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis.
Neoplasms
Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737.
Neoplasms
Granzyme B-activated p53 interacts with Bcl-2 to promote cytotoxic lymphocyte-mediated apoptosis.
Neoplasms
Granzyme B-expressing treg cells are enriched in colorectal cancer and present the potential to eliminate autologous T conventional cells.
Neoplasms
Granzyme B-induced cell death.
Neoplasms
Granzyme B-loaded, cell-selective penetrating and reduction-responsive polymersomes effectively inhibit progression of orthotopic human lung tumor in vivo.
Neoplasms
Granzyme B-mediated apoptosis proceeds predominantly through a Bcl-2-inhibitable mitochondrial pathway.
Neoplasms
Granzyme B-mediated damage of CD8+ T cells impairs graft-versus-tumor effect.
Neoplasms
Granzyme B-positive primary gastric T-cell lymphoma: gastric T-cell lymphoma with the possibility of extrathymic T cell origin.
Neoplasms
Granzyme B: a natural born killer.
Neoplasms
Granzyme B: pro-apoptotic, antiviral and antitumor functions.
Neoplasms
Granzyme M as a novel effector molecule for human cytolytic fusion proteins: CD64-specific cytotoxicity of Gm-H22(scFv) against leukemic cells.
Neoplasms
Granzyme M targets topoisomerase II alpha to trigger cell cycle arrest and caspase-dependent apoptosis.
Neoplasms
GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity.
Neoplasms
Hax-1: a regulator of calcium signaling and apoptosis progression with multiple roles in human disease.
Neoplasms
HBV-specific CD4+ cytotoxic T cells in hepatocellular carcinoma are less cytolytic toward tumor cells and suppress CD8+ T cell-mediated antitumor immunity.
Neoplasms
HCA587 protein vaccine induces specific antitumor immunity mediated by CD4+ T-cells expressing granzyme B in a mouse model of melanoma.
Neoplasms
Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells.
Neoplasms
Hepatic expression of IL-15 mRNA is associated with liver graft acceptance.
Neoplasms
HER2-targeting recombinant protein with truncated pseudomonas exotoxin A translocation domain efficiently kills breast cancer cells.
Neoplasms
Heteroclitic XBP1 peptides evoke tumor-specific memory cytotoxic T lymphocytes against breast cancer, colon cancer, and pancreatic cancer cells.
Neoplasms
High levels of granzyme B expression in invasive cervical carcinoma correlates to poor response to treatment.
Neoplasms
High numbers of granzyme B/CD8-positive tumour-infiltrating lymphocytes in nasopharyngeal carcinoma biopsies predict rapid fatal outcome in patients treated with curative intent.
Neoplasms
High prevalence of activated intraepithelial cytotoxic T lymphocytes and increased neoplastic cell apoptosis in colorectal carcinomas with microsatellite instability.
Neoplasms
High prevalence of Foxp3 and IL17 in MMR-proficient colorectal carcinomas.
Neoplasms
High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells.
Neoplasms
High-dose cyclophosphamide induces specific tumor immunity with concomitant recruitment of LAMP1/CD107a-expressing CD4-positive T cells into tumor sites.
Neoplasms
High-dose IL-2/CD25 fusion protein amplifies vaccine-induced CD4+ and CD8+ neoantigen-specific T cells to promote antitumor immunity.
Neoplasms
Highly Multiplexed Proteomic Analysis of Quantiferon Supernatants To Identify Biomarkers of Latent Tuberculosis Infection.
Neoplasms
hSMG-1 is a granzyme B-associated stress-responsive protein kinase.
Neoplasms
Human and mouse granzyme M display divergent and species-specific substrate specificities.
Neoplasms
Human Asymptomatic Epitopes Identified from the Herpes Simplex Virus Tegument Protein VP13/14 (UL47) Preferentially Recall Polyfunctional Effector Memory CD44high CD62Llow CD8+ TEM Cells and Protect Humanized HLA-A*02:01 Transgenic Mice against Ocular Herpesvirus Infection.
Neoplasms
Human CD8(+) T cells transduced with an additional receptor bispecific for both Mycobacterium tuberculosis and HIV-1 recognize both epitopes.
Neoplasms
Human papilloma virus vaccination induces strong human papilloma virus specific cell-mediated immune responses in HIV-infected adolescents and young adults.
Neoplasms
Human small intestinal mucosa harbours a small population of cytolytically active CD8+ alphabeta T lymphocytes.
Neoplasms
Human TH9 cells are skin-tropic and have autocrine and paracrine proinflammatory capacity.
Neoplasms
Hypopigmented Interface T-Cell Dyscrasia and Hypopigmented Mycosis Fungoides: A Comparative Study.
Neoplasms
Hypoxia Selectively Impairs CAR-T Cells In Vitro.
Neoplasms
Hypoxia Supports Differentiation of Terminally Exhausted CD8 T Cells.
Neoplasms
Identification of cytotoxic T-lymphocyte epitope(s) and its agonist epitope(s) of a novel target for vaccine therapy (PAGE4).
Neoplasms
Identification of mRNAs expressed in tumor-infiltrating lymphocytes by a strategy for rapid and high throughput screening.
Neoplasms
Identification of the BCL2/adenovirus E1B-19K protein-interacting protein 2 (BNIP-2) as a granzyme B target during human natural killer cell-mediated killing.
Neoplasms
IFN-? mediates graft-versus-breast cancer effects via enhancing cytotoxic T lymphocyte activity.
Neoplasms
IFNalpha2b stimulated release of IFNgamma differentially regulates T cell and NK cell mediated tumor cell cytotoxicity.
Neoplasms
IL-15 induces antigen-independent expansion and differentiation of human naive CD8+ T cells in vitro.
Neoplasms
IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells.
Neoplasms
IL-17-producing innate lymphoid cells are restricted to mucosal tissues and are depleted in SIV-infected macaques.
Neoplasms
IL-17/IFN-? double producing CD8+ T (Tc17/IFN-?) cells: a novel cytotoxic T-cell subset converted from Tc17 cells by IL-12.
Neoplasms
IL-17A Promotes Immune Cell Recruitment in Human Esophageal Cancers and the Infiltrating Dendritic Cells Represent a Positive Prognostic Marker for Patient Survival.
Neoplasms
IL-27 enhances IL-15/IL-18-mediated activation of human natural killer cells.
Neoplasms
Imaging for Response Assessment in Cancer Clinical Trials.
Neoplasms
Imbalance Between Soluble and Membrane-Bound CD100 Regulates Monocytes Activity in Hepatitis B Virus-Associated Acute-on-Chronic Liver Failure.
Neoplasms
ImmTAC/Anti-PD-1 antibody combination to enhance killing of cancer cells by reversing regulatory T-cell-mediated immunosuppression.
Neoplasms
Immune activation underlies a sustained clinical response to Yttrium-90 radioembolisation in hepatocellular carcinoma.
Neoplasms
Immune cell constitution in the tumor microenvironment predicts the outcome in diffuse large B-cell lymphoma.
Neoplasms
Immune Escape Mechanism is Impaired in the Microenvironment of Thyroid Lymph Node Metastasis.
Neoplasms
Immune infiltration of spontaneous mouse astrocytomas is dominated by immunosuppressive cells from early stages of tumor development.
Neoplasms
Immune markers measured before treatment predict outcome of intensive phase tuberculosis therapy.
Neoplasms
Immune parameters as markers of tuberculosis extent of disease and early prediction of anti-tuberculosis chemotherapy response.
Neoplasms
Immune Responses Raised in an Experimental Colon Carcinoma Model Following Oral Administration of Lactobacillus casei.
Neoplasms
Immune responses to a class II helper peptide epitope in patients with stage III/IV resected melanoma.
Neoplasms
Immune-activation gene expression in clinically stable renal allograft biopsies: molecular evidence for subclinical rejection.
Neoplasms
Immunohistochemical and genetic analysis of Chinese nasal natural killer/T-cell lymphomas.
Neoplasms
Immunohistochemical expression of granzyme B and vascular endothelial growth factor (VEGF) in normal uterine cervices and low and high grade squamous intraepithelial lesions.
Neoplasms
Immunohistochemical investigations on the expression of programmed cell death ligand 1, human leukocyte antigens G and E, and granzyme B in intraoral mucoepidermoid carcinoma.
Neoplasms
Immunological analysis of phase II glioblastoma dendritic cell vaccine (Audencel) trial: immune system characteristics influence outcome and Audencel up-regulates Th1-related immunovariables.
Neoplasms
Immunological protection against HPV16 E7-expressing human esophageal cancer cell challenge by a novel HPV16-E6/E7 fusion protein based-vaccine in a Hu-PBL-SCID mouse model.
Neoplasms
Immunophenotype of lymphocytic infiltration in medullary carcinoma of the breast.
Neoplasms
Immunophenotypes Based on the Tumor Immune Microenvironment Allow for Unsupervised Penile Cancer Patient Stratification.
Neoplasms
Immunostimulating and Antimetastatic Effects of Polysaccharides Purified from Ginseng Berry.
Neoplasms
Immunosuppressive tumor microenvironment in occupational cholangiocarcinoma: Supportive evidence for the efficacy of immune checkpoint inhibitor therapy.
Neoplasms
Immunotherapeutic targeting of membrane hsp70-expressing tumors using recombinant human granzyme B.
Neoplasms
Impaired tumor necrosis factor-? secretion by CD4 T cells during respiratory syncytial virus bronchiolitis associated with recurrent wheeze.
Neoplasms
Impairment of Granzyme B-Producing Regulatory B Cells Correlates with Exacerbated Rheumatoid Arthritis.
Neoplasms
Improved cytotoxic T-lymphocyte immune responses to a tumor antigen by vaccines co-expressing the SLAM-associated adaptor EAT-2.
Neoplasms
Improving the in vivo persistence, distribution and function of cytotoxic T lymphocytes by inhibiting the tumor immunosuppressive microenvironment.
Neoplasms
Increased antitumor activities of glypican-3-specific chimeric antigen receptor-modified T cells by coexpression of a soluble PD1-CH3 fusion protein.
Neoplasms
Increased expression of Apaf-1 and procaspase-3 and the functionality of intrinsic apoptosis apparatus in non-small cell lung carcinoma.
Neoplasms
Increased expression of perforin and granzyme B genes in patients with metastatic melanoma treated with recombinant interleukin-2.
Neoplasms
Increased frequency of Foxp3+ regulatory T cells in mice with hepatocellular carcinoma.
Neoplasms
Increased Interleukin-35 suppresses peripheral CD14+ monocytes function in patients with Kawasaki disease.
Neoplasms
Increased natural killer T-like cells are a major source of pro-inflammatory cytokines and granzymes in lung transplant recipients.
Neoplasms
Increased Number of Circulating CD8/CD26 T Cells in the Blood of Duchenne Muscular Dystrophy Patients Is Associated with Augmented Binding of Adenosine Deaminase and Higher Muscular Strength Scores.
Neoplasms
Increased proteinase inhibitor-9 (PI-9) and reduced granzyme B in lung cancer: Mechanism for immune evasion?
Neoplasms
Increased tumor-infiltrating CD45RA(-)CCR7(-) regulatory T-cell subset with immunosuppressive properties foster gastric cancer progress.
Neoplasms
Indolent peripheral T-cell lymphoma involving the gastrointestinal tract.
Neoplasms
Inducible MyD88/CD40 synergizes with IL-15 to enhance antitumor efficacy of CAR-NK cells.
Neoplasms
Induction of CD4(+) and CD8(+) anti-tumor effector T cell responses by bacteria mediated tumor therapy.
Neoplasms
Induction of granzyme B expression in T-cell receptor/CD28-stimulated human regulatory T cells is suppressed by inhibitors of the PI3K-mTOR pathway.
Neoplasms
Infiltrating CTLs in human glioblastoma establish immunological synapses with tumorigenic cells.
Neoplasms
Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients.
Neoplasms
Inflammatory Gene Expression Profile and Defective Interferon-? and Granzyme K in Natural Killer Cells From Systemic Juvenile Idiopathic Arthritis Patients.
Neoplasms
Inhibition of DNA-PK with AZD7648 Sensitizes Tumor Cells to Radiotherapy and Induces Type I IFN-Dependent Durable Tumor Control.
Neoplasms
Inhibition of galectin-3 augments the antitumor efficacy of PD-L1 blockade in non-small-cell lung cancer.
Neoplasms
Inhibition of NLRP3 inflammasome activation in myeloid-derived suppressor cells by andrographolide sulfonate contributes to 5-FU sensitization in mice.
Neoplasms
Inhibition of WEE1 kinase and cell cycle checkpoint activation sensitizes head and neck cancers to natural killer cell therapies.
Neoplasms
Integrin ?v?8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy.
Neoplasms
Integrin alphavbeta6 promotes tumor tolerance in colorectal cancer.
Neoplasms
Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma.
Neoplasms
Interaction Networks Converging on Immunosuppressive Roles of Granzyme B: Special Niches Within the Tumor Microenvironment.
Neoplasms
Interferon-Gamma Receptor Signaling Plays an Important Role in Restraining Murine Ovarian Tumor Progression.
Neoplasms
Interleukin 10 enhanced CD8+ T cell activity and reduced CD8(+) T cell apoptosis in patients with diffuse large B cell lymphoma.
Neoplasms
Interleukin 21-induced granzyme B-expressing B cells infiltrate tumors and regulate T cells.
Neoplasms
Interleukin-10 production by tumor infiltrating macrophages plays a role in Human Papillomavirus 16 tumor growth.
Neoplasms
Interleukin-15-induced CD56(+) myeloid dendritic cells combine potent tumor antigen presentation with direct tumoricidal potential.
Neoplasms
Interleukin-35 suppresses antitumor activity of circulating CD8+ T cells in osteosarcoma patients.
Neoplasms
Interleukin-9-secreting CD4+ T cells regulate CD8+ T cells cytotoxicity in patients with acute coronary syndromes.
Neoplasms
Interruption of MDM2 signaling augments MDM2-targeted T cell-based antitumor immunotherapy through antigen-presenting machinery.
Neoplasms
Intraepithelial lymphocytes in normal human intestine do not express proteins associated with cytolytic function.
Neoplasms
Intrahepatic lymphocyte expression of dipeptidyl peptidase I-processed granzyme B and perforin induces hepatocyte expression of serine proteinase inhibitor 6 (Serpinb9/SPI-6).
Neoplasms
Intratumoral CD103+CD4+ T cell infiltration defines immunoevasive contexture and poor clinical outcomes in gastric cancer patients.
Neoplasms
Intratumoral plasmacytoid dendritic cells as a poor prognostic factor for hepatocellular carcinoma following curative resection.
Neoplasms
Involvement of granzyme B and perforin in suppressing nodal metastasis of cancer cells in breast and lung cancers.
Neoplasms
In Vivo Tumorigenesis, Osteolytic Sarcomas, and Tumorigenic Cell Lines from Transgenic Mice Expressing the Human T-Lymphotropic Virus Type 1 (HTLV-1) Tax Viral Oncogene.
Neoplasms
Kctd9 Deficiency Impairs Natural Killer Cell Development and Effector Function.
Neoplasms
L-Arginine supplementation inhibits the growth of breast cancer by enhancing innate and adaptive immune responses mediated by suppression of MDSCs in vivo.
Neoplasms
Lack of terminally differentiated tumor-specific CD8+ T cells at tumor site in spite of antitumor immunity to self-antigens in human metastatic melanoma.
Neoplasms
LC3B upregulation by NANOG promotes immune resistance and stem-like property through hyperactivation of EGFR signaling in immune-refractory tumor cells.
Neoplasms
Lenalidomide in an in vitro Dendritic Cell Model for Malignant Gliomas.
Neoplasms
Leucine rich repeats and calponin homology domain containing 1 inhibits NK-92 cell cytotoxicity through attenuating Src signaling.
Neoplasms
Liposomal Delivery of Mitoxantrone and a Cholesteryl Indoximod Prodrug Provides Effective Chemo-immunotherapy in Multiple Solid Tumors.
Neoplasms
Loss of STAT3 in murine NK cells enhances NK cell-dependent tumor surveillance.
Neoplasms
Lung cancer is associated with decreased expression of perforin, granzyme B and interferon (IFN)-? by infiltrating lung tissue T cells, natural killer (NK)?T-like and NK cells.
Neoplasms
Lymphocyte activation gene 3 negatively regulates the function of intrahepatic hepatitis C virus-specific CD8+ T cells.
Neoplasms
Lymphocytic bronchiolitis is associated with inadequate suppression of blood T-cell granzyme B, IFN-gamma, and TNF-alpha.
Neoplasms
Mast cells decrease efficacy of anti-angiogenic therapy by secreting matrix-degrading granzyme B.
Neoplasms
Mitomycin C enhanced the efficacy of PD-L1 blockade in non-small cell lung cancer.
Neoplasms
Modulation of the Tumor Cell Phenotype by IFN-{gamma} Results in Resistance of Uveal Melanoma Cells to Granule-Mediated Lysis by Cytotoxic Lymphocytes.
Neoplasms
Monoclonal anti-CD8 therapy induces disease amelioration in the K/BxN mouse model of spontaneous chronic polyarthritis.
Neoplasms
Mouse CD8+NKT-like cells exert dual cytotoxicity against mouse tumor cells and myeloid-derived suppressor cells.
Neoplasms
Mouse Cytotoxic T Cell-derived Granzyme B Activates the Mitochondrial Cell Death Pathway in a Bim-dependent Fashion.
Neoplasms
Multiple molecular and cellular changes associated with tumour stasis and regression during IL-12 therapy of a murine breast cancer model.
Neoplasms
Multiplex Cytokine Profiling Identifies Interleukin-27 as a Novel Biomarker for Neonatal Early Onset Sepsis.
Neoplasms
Mutations to bid cleavage sites protect hepatocytes from apoptosis after ischemia/reperfusion injury.
Neoplasms
Mycobacteria activate ?? T-cell anti-tumour responses via cytokines from type 1 myeloid dendritic cells: a mechanism of action for cancer immunotherapy.
Neoplasms
Nasal natural killer/T cell lymphoma with cutaneous involvement: case report and Chinese literature review reported in China mainland.
Neoplasms
Nasal vaccination stimulates CD8(+) T cells for potent protection against mucosal Brucella melitensis challenge.
Neoplasms
Nasal-type extranodal natural killer/T-cell lymphoma presenting with extensive leg ulcers.
Neoplasms
Natural killer cell-mediated ablation of metastatic liver tumors by hydrodynamic injection of IFNalpha gene to mice.
Neoplasms
Natural killer cells induce distinct modes of cancer cell death: Discrimination, quantification, and modulation of apoptosis, necrosis, and mixed forms.
Neoplasms
Natural killer cells limit cardiac inflammation and fibrosis by halting eosinophil infiltration.
Neoplasms
Natural killer cells promote tissue injury and systemic inflammatory responses during fatal Ehrlichia-induced toxic shock-like syndrome.
Neoplasms
Near-Infrared Fluorescent Macromolecular Reporters for Real-Time Imaging and Urinalysis of Cancer Immunotherapy.
Neoplasms
Neoplasms derived from plasmacytoid monocytes/interferon-producing cells: variability of CD56 and granzyme B expression.
Neoplasms
Niclosamide, an antihelmintic drug, enhances efficacy of PD-1/PD-L1 immune checkpoint blockade in non-small cell lung cancer.
Neoplasms
Nicotine exhausts CD8+ T cells against tumor cells through increasing miR-629-5p to repress IL2RB-mediated granzyme B expression.
Neoplasms
Nintedanib promotes antitumour immunity and shows antitumour activity in combination with PD-1 blockade in mice: potential role of cancer-associated fibroblasts.
Neoplasms
NK cells dysfunction in systemic lupus erythematosus: relation to disease activity.
Neoplasms
NK cells switch from granzyme B to death receptor-mediated cytotoxicity during serial killing.
Neoplasms
Nodal CD8 positive cytotoxic T-cell lymphoma: a distinct clinicopathological entity.
Neoplasms
Nodal cytotoxic lymphoma spectrum: a clinicopathologic study of 66 patients.
Neoplasms
Non-Malignant CD30+ Cells in Contralateral Peri-Implant Capsule of Patient With BIA-ALCL: A Premalignant Step?
Neoplasms
Non-redundant activity of GSK-3? and GSK-3? in T cell-mediated tumor rejection.
Neoplasms
Non-replicating Newcastle Disease Virus as an adjuvant for DNA vaccine enhances antitumor efficacy through the induction of TRAIL and granzyme B expression.
Neoplasms
Nonimmediate allergic reactions induced by drugs: pathogenesis and diagnostic tests.
Neoplasms
Normal regulatory alpha/beta T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor beta in vivo.
Neoplasms
NPM-ALK and the JunB transcription factor regulate the expression of cytotoxic molecules in ALK-positive, anaplastic large cell lymphoma.
Neoplasms
Nuclear factor-?B1 controls the functional maturation of dendritic cells and prevents the activation of autoreactive T cells.
Neoplasms
Nuclear transport of granzyme B (fragmentin-2). Dependence of perforin in vivo and cytosolic factors in vitro.
Neoplasms
Nucleofection of non-B cells with mini-Epstein-Barr virus DNA.
Neoplasms
Oncolytic Vaccinia Virus Gene Modification and Cytokine Expression Effects on Tumor Infection, Immune Response, and Killing.
Neoplasms
Optimization of an elispot assay to detect cytomegalovirus-specific CD8+ T lymphocytes.
Neoplasms
p50 suppresses cytotoxic T lymphocyte effector function to regulate tumor immune escape and response to immunotherapy.
Neoplasms
PD-1 Expression and Function of T-Cell Subsets in TILs From Human Lung Cancer.
Neoplasms
PD-1 Immune Checkpoint Blockade Promotes Therapeutic Cancer Vaccine to Eradicate Lung Cancer.
Neoplasms
PD1-CD28 Fusion Protein Enables CD4+ T Cell Help for Adoptive T Cell Therapy in Models of Pancreatic Cancer and Non-hodgkin Lymphoma.
Neoplasms
Percentage of activated cytotoxic T-lymphocytes in anaplastic large cell lymphoma and Hodgkin's disease: an independent biological prognostic marker.
Neoplasms
Perforin and Granzyme B Expressed by Murine Myeloid-Derived Suppressor Cells: A Study on Their Role in Outgrowth of Cancer Cells.
Neoplasms
Perforin and granzyme expression in cytotoxic T-cell lymphomas.
Neoplasms
Peripheral T-cell lymphoma arising from an intraglandular lymph node in the parotid gland: a case report and literature review.
Neoplasms
Peroxisome proliferator-activated receptor alpha deficiency impairs regulatory T cell functions: Possible application in the inhibition of melanoma tumor growth in mice.
Neoplasms
Plasmodium infection inhibits the expansion and activation of MDSCs and Tregs in the tumor microenvironment in a murine Lewis lung cancer model.
Neoplasms
Poor clinical outcomes and immunoevasive contexture in interleukin-9 abundant muscle-invasive bladder cancer.
Neoplasms
Porphyromonas gingivalis Placental Atopobiosis and Inflammatory Responses in Women With Adverse Pregnancy Outcomes.
Neoplasms
Possible key role of granzyme B in keratoacanthoma regression.
Neoplasms
Potential Role of Pleural Fluid Cytokine Profile in Myelomatous Pleural Effusions.
Neoplasms
Potentiation of a tumor cell susceptibility to autologous CTL killing by restoration of wild-type p53 function.
Neoplasms
Primary bony peripheral T-cell lymphoma mimicking nasal type NK/T-cell lymphoma: a case report.
Neoplasms
Primary CD56+ NK/T-cell lymphoma of the rectum accompanied with refractory ulcerative colitis.
Neoplasms
Primary central nervous system extranodal NK/T cell lymphoma, nasal type, with antecedent hemophagocytic syndrome in a child.
Neoplasms
Primary central nervous system extranodal NK/T-cell lymphoma, nasal type: case report and review of the literature.
Neoplasms
Primary extranodal natural Killer/T-cell lymphoma in a child in the colon: A case report.
Neoplasms
Primary gastric natural killer/T-cell lymphoma with diffuse CD30 expression and without CD56 expression: A case report.
Neoplasms
Primary intestinal gamma-delta T-cell lymphoma with evidence of Epstein-Barr virus.
Neoplasms
Primary laryngeal NK/T-cell non-Hodgkin lymphoma: A case report.
Neoplasms
Primary mucosal CD30-positive T-cell lymphoproliferative disorders of the head and neck rarely involving epiglottis: clinicopathological, immunohistomchemical and genetic features of a case.
Neoplasms
Primary rare anaplastic large cell lymphoma, ALK positive in small intestine: case report and review of the literature.
Neoplasms
Primary Tr1 cells from metastatic melanoma eliminate tumor-promoting macrophages through granzyme B- and perforin-dependent mechanisms.
Neoplasms
Primary Tumors Limit Metastasis Formation through Induction of IL15-Mediated Cross-Talk between Patrolling Monocytes and NK Cells.
Neoplasms
PRMT5 disruption drives antitumor immunity in cervical cancer by reprogramming T cell-mediated response and regulating PD-L1 expression.
Neoplasms
Psoriasis confined strictly to vitiligo areas - a Koebner-like phenomenon?
Neoplasms
Radiation-enhanced delivery of systemically administered amphiphilic-CpG oligodeoxynucleotide.
Neoplasms
Radiotherapy increases the permissiveness of established mammary tumors to rejection by immunomodulatory antibodies.
Neoplasms
Rapid reuptake of granzyme B leads to emperitosis: an apoptotic cell-in-cell death of immune killer cells inside tumor cells.
Neoplasms
Rapid turnover of the CD8(+)CD28(-) T-cell subset of effector cells in the circulation of patients with head and neck cancer.
Neoplasms
Rat CD4+CD8+ Macrophages Kill Tumor Cells through an NKG2D- and Granzyme/Perforin-Dependent Mechanism.
Neoplasms
Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy.
Neoplasms
Recipient leukocyte infusion enhances the local and systemic graft-versus-neuroblastoma effect of allogeneic bone marrow transplantation in mice.
Neoplasms
Regulation of CD28 expression on umbilical cord blood and adult peripheral blood CD8(+) T cells by interleukin(IL)-15/IL-21.
Neoplasms
Regulatory effect of Ganoderma lucidum polysaccharides on cytotoxic T-lymphocytes induced by dendritic cells in vitro.
Neoplasms
Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells.
Neoplasms
Regulatory T cells specifically suppress conventional CD8?? T cells in intestinal tumors of APCMin/+ mice.
Neoplasms
Relationship between clinical course of nivolumab-related myositis and immune status in a patient with Hodgkin's lymphoma after allogeneic hematopoietic stem cell transplantation.
Neoplasms
Resistance of cancers to immunologic cytotoxicity and adoptive immunotherapy via X-linked inhibitor of apoptosis protein expression and coexisting defects in mitochondrial death signaling.
Neoplasms
Restraint and Social Isolation Stressors Differentially Regulate Adaptive Immunity and Tumor Angiogenesis in a Breast Cancer Mouse Model.
Neoplasms
Robust hepatitis B vaccine-reactive T cell responses in failed humoral immunity.
Neoplasms
Role of Tumor Necrosis Factor-? and Natural Killer Cells in Uterine Artery Function and Pregnancy Outcome in the Stroke-Prone Spontaneously Hypertensive Rat.
Neoplasms
Sarcomatoid variant of ALK- anaplastic large cell lymphoma involving multiple lymph nodes and both lungs with production of proinflammatory cytokines: report of a case and review of literature.
Neoplasms
Selective recruitment of ?? T cells by a bispecific antibody for the treatment of acute myeloid leukemia.
Neoplasms
Serglycin--structure and biology.
Neoplasms
Serous effusion cytology of extranodal natural killer/T-cell lymphoma.
Neoplasms
Serpins prevent granzyme-induced death in a species-specific manner.
Neoplasms
SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade.
Neoplasms
Signatures and Specificity of Tissue-Resident Lymphocytes Identified in Human Renal Peritumor and Tumor Tissue.
Neoplasms
Solid tumor-targeted infiltrating cytotoxic T lymphocytes retained by a superantigen fusion protein.
Neoplasms
Structure and Function of HLA-A*02-Restricted Hantaan Virus Cytotoxic T-Cell Epitope That Mediates Effective Protective Responses in HLA-A2.1/K(b) Transgenic Mice.
Neoplasms
Studies of hormonal regulation, phenotype plasticity, bone metastasis, and experimental therapeutics in androgen-repressed human prostate cancer (ARCaP) model.
Neoplasms
Subcutaneous panniculitis-like T-cell lymphoma: presentation of 2 cases and observations.
Neoplasms
SUMO2 overexpression enhances the generation and function of interleukin-17-producing CD8(+) T cells in mice.
Neoplasms
Suppression of granzyme B activity and caspase-3 activation in leukaemia cells constitutively expressing the protease inhibitor 9.
Neoplasms
Survivin and Granzyme B-induced apoptosis, a novel anticancer therapy.
Neoplasms
Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin.
Neoplasms
Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors.
Neoplasms
T cell receptor-zeta and granzyme B expression in mononuclear cell infiltrates in normal colon mucosa and colon carcinoma.
Neoplasms
T cells expressing NKG2D chimeric antigen receptors efficiently eliminate glioblastoma and cancer stem cells.
Neoplasms
T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice.
Neoplasms
T-cell TGF-? signaling abrogation restricts medulloblastoma progression.
Neoplasms
T-Cell-Derived Nanovesicles for Cancer Immunotherapy.
Neoplasms
TAGLN2-mediated actin stabilization at the immunological synapse: implication for cytotoxic T cell control of target cells.
Neoplasms
Target Reprogramming Lysosomes of CD8+ T Cells by a Mineralized Metal-Organic Framework for Cancer Immunotherapy.
Neoplasms
Targeted ex vivo reduction of CD64-positive monocytes in chronic myelomonocytic leukemia and acute myelomonocytic leukemia using human granzyme B-based cytolytic fusion proteins.
Neoplasms
Targeted intracellular protein delivery based on hyaluronic acid-green tea catechin nanogels.
Neoplasms
Targeting and Therapy of Glioblastoma in a Mouse Model Using Exosomes Derived From Natural Killer Cells.
Neoplasms
Targeting CXCR4 potentiates anti-PD-1 efficacy modifying the tumor microenvironment and inhibiting neoplastic PD-1.
Neoplasms
Targeting granzyme B to tumor cells using a yoked human chorionic gonadotropin.
Neoplasms
Targeting miR-23a in CD8+ cytotoxic T lymphocytes prevents tumor-dependent immunosuppression.
Neoplasms
Targeting of Tumor Neovasculature with GrB/VEGF121, a Novel Cytotoxic Fusion Protein.
Neoplasms
Taste receptor T1R1/T1R3 promotes the tumoricidal activity of hepatic CD49a+ CD49b- natural killer cells.
Neoplasms
Testicular natural killer/t-cell lymphoma, nasal type, of true natural killer-cell origin.
Neoplasms
TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance.
Neoplasms
The analysis of estrogen receptor-? positive breast cancer stem-like cells unveils a high expression of the serpin proteinase inhibitor PI-9: Possible regulatory mechanisms.
Neoplasms
The Antidiabetic Agent Acarbose Improves Anti-PD-1 and Rapamycin Efficacy in Preclinical Renal Cancer.
Neoplasms
The CD8 T cell response to vaccinia virus exhibits site-dependent heterogeneity of functional responses.
Neoplasms
The combination of TLR-9 adjuvantation and electroporation mediated delivery enhances in vivo anti-tumor responses after vaccination with HPV-16 E7 encoding DNA.
Neoplasms
The decreased susceptibility of metastatic melanoma cells to killing involves an alteration of CTL reactivity.
Neoplasms
The effect of MEK1/2 inhibitors on cisplatin-induced acute kidney injury (AKI) and cancer growth in mice.
Neoplasms
The exosomes derived from CAR-T cell efficiently target mesothelin and reduce triple-negative breast cancer growth.
Neoplasms
The Herpes Simplex Virus Latency-Associated Transcript Gene Is Associated with a Broader Repertoire of Virus-Specific Exhausted CD8+ T Cells Retained within the Trigeminal Ganglia of Latently Infected HLA Transgenic Rabbits.
Neoplasms
The high expression of Fractalkine results in a better prognosis for colorectal cancer patients.
Neoplasms
The localization and density of immune cells in primary tumors of human metastatic colorectal cancer shows an association with response to chemotherapy.
Neoplasms
The PD-1 expressing immune phenotype of T cell exhaustion is prominent in the 'immunoreactive' microenvironment of colorectal carcinoma.
Neoplasms
The peptide loop consisting of amino acids 139-157 of human granzyme B (fragmentin 2) contains an immunodominant epitope recognized by the mouse.
Neoplasms
The pharmalogical reactivation of p53 function improves breast tumor cell lysis by granzyme B and NK cells through induction of autophagy.
Neoplasms
The phenotype and activation status of regulatory T cells during Friend retrovirus infection.
Neoplasms
The Potential Roles of Mucosa-Associated Invariant T Cells in the Pathogenesis of Gut Graft-Versus-Host Disease After Hematopoietic Stem Cell Transplantation.
Neoplasms
The Profile and Role of Tumor-infiltrating Lymphocytes in Hepatocellular Carcinoma: An Immunohistochemical Study.
Neoplasms
The ratio of intra-tumoral regulatory T cells (Foxp3+)/helper T cells (CD4+) is a prognostic factor and associated with recurrence pattern in gastric cardia cancer.
Neoplasms
The Role of Autophagy in Tumor Immunology-Complex Mechanisms That May Be Explored Therapeutically.
Neoplasms
The role of cytotoxic and regulatory T cells in relapsed/refractory Hodgkin lymphoma.
Neoplasms
The Role of Indoleamine 2,3-Dioxygenase in Diethylnitrosamine-Induced Liver Carcinogenesis.
Neoplasms
The significance of granzyme B expression in patients with angiocentric lymphoma of the head and neck.
Neoplasms
The use of a TLR2 agonist-based adjuvant for enhancing effector and memory CD8 T-cell responses.
Neoplasms
Therapeutic blockade of activin-A improves NK cell function and antitumor immunity.
Neoplasms
Time post-lung transplant correlates with increasing peripheral blood T cell granzyme B and proinflammatory cytokines.
Neoplasms
Tolerization of tumor-specific T cells despite efficient initial priming in a primary murine model of prostate cancer.
Neoplasms
Topical treatment of all-trans retinoic acid inhibits murine melanoma partly by promoting CD8(+) T-cell immunity.
Neoplasms
Tr1 responses are elevated in asymptomatic H. pylori-infected individuals and are functionally impaired in H. pylori-gastric cancer patients.
Neoplasms
Trafficking phenotype and production of granzyme B by double negative B cells (IgG(+)IgD(-)CD27(-)) in the elderly.
Neoplasms
TRAIL-Receptor 4 Modulates ?? T Cell-Cytotoxicity Toward Cancer Cells.
Neoplasms
Treatment combining RU486 and Ad5IL-12 vector attenuates the growth of experimentally formed prostate tumors and induces changes in the tumor sentinel lymph nodes of mice.
Neoplasms
Trichosanthin cooperates with Granzyme B to restrain tumor formation in tongue squamous cell carcinoma.
Neoplasms
Trichosanthin increases Granzyme B penetration into tumor cells by upregulation of CI-MPR on the cell surface.
Neoplasms
Triple costimulation via CD80, 4-1BB, and CD83 ligand elicits the long-term growth of V?9V?2 T cells in low levels of IL-2.
Neoplasms
Triple Therapy with MerTK and PD1 Inhibition plus Radiotherapy Promotes Abscopal Antitumor Immune Responses.
Neoplasms
Truncated CD200 stimulates tumor immunity leading to fewer lung metastases in a novel Wistar rat metastasis model.
Neoplasms
Tumor Infiltrating Effector Memory Antigen-Specific CD8+ T Cells Predict Response to Immune Checkpoint Therapy.
Neoplasms
Tumor Lactic Acidosis: Protecting Tumor by Inhibiting Cytotoxic Activity Through Motility Arrest and Bioenergetic Silencing.
Neoplasms
Tumor location impacts immune response in mouse models of colon cancer.
Neoplasms
Tumor perfusion enhancement by ultrasound stimulated microbubbles potentiates PD-L1 blockade of MC38 colon cancer in mice.
Neoplasms
Tumor-derived granzyme B-expressing neutrophils acquire antitumor potential after lipid A treatment.
Neoplasms
Tumor-infiltrating mucosal-associated invariant T (MAIT) cells retain expression of cytotoxic effector molecules.
Neoplasms
Tumor-infiltrating regulatory T cells inhibit endogenous cytotoxic T cell responses to lung adenocarcinoma.
Neoplasms
Tumor-specific CD4(+) T cells develop cytotoxic activity and eliminate virus-induced tumor cells in the absence of regulatory T cells.
Neoplasms
Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy.
Neoplasms
Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells.
Neoplasms
Tumour-infiltrating lymphocytes in colorectal cancer with microsatellite instability are activated and cytotoxic.
Neoplasms
Type I interferon-associated recruitment of cytotoxic lymphocytes: a common mechanism in regressive melanocytic lesions.
Neoplasms
Understanding key assay parameters that affect measurements of trastuzumab-mediated ADCC against Her2 positive breast cancer cells.
Neoplasms
Up-regulation of alternate co-stimulatory molecules on proinflammatory CD28null T cells in bronchiolitis obliterans syndrome.
Neoplasms
Up-regulation of granzyme B and perforin by staphylococcal enterotoxin C2 mutant induces enhanced cytotoxicity in Hepa1-6 cells.
Neoplasms
Valproic acid triggers radiation-induced abscopal effect by modulating the unirradiated tumor immune microenvironment in a rat model of breast cancer.
Neoplasms
Villus epithelial injury induced by infection with the nematode Nippostrongylus brasiliensis is associated with upregulation of granzyme B.
Neoplasms
Warburg phenotype in renal cell carcinoma: High expression of glucose-transporter 1 (GLUT-1) correlates with low CD8(+) T-cell infiltration in the tumor.
Neoplasms
ZIKA virus infection causes persistent chorioretinal lesions.
Neoplasms
Zoledronate facilitates large-scale ex vivo expansion of functional gammadelta T cells from cancer patients for use in adoptive immunotherapy.
Neoplasms
[Aggressive NK/T cell leukemia/lymphoma associated with EBV].
Neoplasms
[Clinicopathological characteristics of adult T cell leukemia/lymphoma].
Neoplasms
[Correlation analysis of the prognosis of HPV positive oropharyngeal cancer patients with T cell infiltration and neoantigen load].
Neoplasms
[Diffuse large B-cell lymphoma with aberrant expression of CD56: a clinicopathologic and immunohistochemical study].
Neoplasms
[Effect of bushen recipe on the immune effector molecules of natural killer cells in patients with chronic hepatitis B]
Neoplasms
[Expression profile of immune effector molecules in natural killer cells in patients with chronic hepatitis B]
Neoplasms
[Isolated central nervous system relapse in type II enteropathy-associated T cell lymphoma].
Neoplasms
[Kv1.3 potassium channel expression changes after CD4(+) and subsets CD28(null)/CD28(+)T cells activation in peripheral blood of patients with acute coronary syndrome]
Neoplasms
[Primary nasal natural killer/T-cell lymphomas: classification and clinicopathological features]
Neoplasms
[The modulatory activity of T cell immunoglobulin and mucin domain-containing protein 3 on T lymphocytes in patients with chronic heart failure].
Neuroblastoma
Ex vivo activation of CD56+ immune cells that eradicate neuroblastoma.
Neuroinflammatory Diseases
c-Met is expressed by highly autoreactive encephalitogenic CD8+ cells.
Neuroinflammatory Diseases
Eomesodermin-expressing T-helper cells are essential for chronic neuroinflammation.
Neuroinflammatory Diseases
Pathological mechanism of secondary-progressive multiples sclerosis and its animal model.
Neuroinflammatory Diseases
Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1?.
Neuromyelitis Optica
Paucity of natural killer and cytotoxic T cells in human neuromyelitis optica lesions.
Neutropenia
Chronic clonal proliferative disease of gamma-delta (gammadelta) T-cells in a patient with rheumatoid arthritis and neutropenia: lack of the morphology and the immunophenotype of large granular lymphocytes.
Nevus
Type I interferon-associated recruitment of cytotoxic lymphocytes: a common mechanism in regressive melanocytic lesions.
Nevus, Halo
A similar local immune and oxidative stress phenotype in vitiligo and halo nevus.
Nevus, Halo
Type I interferon-associated recruitment of cytotoxic lymphocytes: a common mechanism in regressive melanocytic lesions.
Newcastle Disease
Non-replicating Newcastle Disease Virus as an adjuvant for DNA vaccine enhances antitumor efficacy through the induction of TRAIL and granzyme B expression.
Non-alcoholic Fatty Liver Disease
Nutrigenetic Interactions Might Modulate the Antioxidant and Anti-Inflammatory Status in Mastiha-Supplemented Patients With NAFLD.
Obesity
Granzyme B Expression in Visceral Adipose Tissue Associates With Local Inflammation and Glyco-Metabolic Alterations in Obesity.
Obesity
Overweight and obese adult humans have a defective cellular immune response to pandemic H1N1 influenza A virus.
Obesity
The serine protease granzyme B as an inflammatory marker, in relation to the insulin receptor cleavage in human obesity and type 2 diabetes mellitus.
Obstetric Labor, Premature
Effector and Activated T Cells Induce Preterm Labor and Birth That Is Prevented by Treatment with Progesterone.
Osteosarcoma
Interleukin-35 suppresses antitumor activity of circulating CD8+ T cells in osteosarcoma patients.
Osteosarcoma
MicroRNA-200a induces immunosuppression by promoting PTEN-mediated PD-L1 upregulation in osteosarcoma.
Osteosarcoma
PD?L1/PD?1 axis serves an important role in natural killer cell?induced cytotoxicity in osteosarcoma.
Overweight
Overweight and obese adult humans have a defective cellular immune response to pandemic H1N1 influenza A virus.
Pancreatic Neoplasms
CD40 Agonist Overcomes T Cell Exhaustion Induced by Chronic Myeloid Cell IL-27 Production in a Pancreatic Cancer Preclinical Model.
Pancreatic Neoplasms
Engraftment of mesothelin chimeric antigen receptor using a hybrid Sleeping Beauty/minicircle vector into NK-92MI cells for treatment of pancreatic cancer.
Papillon-Lefevre Disease
A family with Papillon-Lefevre syndrome reveals a requirement for cathepsin C in granzyme B activation and NK cell cytolytic activity.
Paracoccidioidomycosis
Characterization of cytotoxic immune response in skin and mucosal lesions of paracoccidioidomycosis.
Paramyxoviridae Infections
Specific inhibition of granzyme B by parainfluenza virus type 3.
Pemphigoid, Bullous
Collagen XVII Processing and Blistering Skin Diseases.
Pemphigoid, Bullous
Granzyme B inhibition reduces disease severity in autoimmune blistering diseases.
Peptic Ulcer
Perforin and granzyme B of cytotoxic T lymphocyte mediate apoptosis irrespective of Helicobacter pylori infection: possible act as a trigger of peptic ulcer formation.
Persistent Infection
Collapse of Cytolytic Potential in SIV-Specific CD8+ T Cells Following Acute SIV Infection in Rhesus Macaques.
Persistent Infection
Lymphocytic choriomeningitis virus persistence promotes effector-like memory differentiation and enhances mucosal T cell distribution.
Pleural Effusion
Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling.
Pleural Effusion
Potential Role of Pleural Fluid Cytokine Profile in Myelomatous Pleural Effusions.
Pneumocystis Infections
Memory CD4+ T cells are required for optimal NK cell effector functions against the opportunistic fungal pathogen Pneumocystis murina.
Pneumonia
Granzyme B deficiency exacerbates lung inflammation in mice after acute lung injury.
Pneumonia
Natural killer cell NKG2D and granzyme B are critical for allergic pulmonary inflammation.
Pneumonia
Perforin and granzyme B gene-expressing cells in bronchoalveolar lavage fluids from lung allograft recipients displaying cytomegalovirus pneumonitis.
Pneumonia
Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection.
Pneumovirus Infections
Granzyme A- and B-cluster deficiency delays acute lung injury in pneumovirus-infected mice.
Polymyositis
Expression of human IAP-like protein in skeletal muscle: a possible explanation for the rare incidence of muscle fiber apoptosis in T-cell mediated inflammatory myopathies.
Polymyositis
Polymyositis in solid organ transplant recipients receiving tacrolimus.
Poxviridae Infections
A pro-survival role for the intracellular granzyme B inhibitor Serpinb9 in natural killer cells during poxvirus infection.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genetic variants of human granzyme B predict transplant outcomes after HLA matched unrelated bone marrow transplantation for myeloid malignancies.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
A novel CD7 chimeric antigen receptor-modified NK-92MI cell line targeting T-cell acute lymphoblastic leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
The presence of CD56/CD16 in T-cell acute lymphoblastic leukaemia correlates with the expression of cytotoxic molecules and is associated with worse response to treatment.
Primary Myelofibrosis
[Bone marrow-restricted involvement of T-cell granular lymphocyte leukemia]
Prostatic Neoplasms
A Possible Role for Perforin and Granzyme B in Resveratrol Enhanced Radiosensitivity of Prostate Cancer.
Prostatic Neoplasms
Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis.
Prostatic Neoplasms
Inhibition of Granzyme B by PI-9 protects prostate cancer cells from apoptosis.
Prostatic Neoplasms
Secretome analysis reveals upregulated granzyme B in human androgen-repressed prostate cancer cells with mesenchymal and invasive phenotype.
Prostatic Neoplasms
[Increased Notch receptors induces CD8(+) T cell exhaustion in patients with prostate cancer].
Prostatitis
Oxidative stress in prostatic fluid of patients with chronic pelvic pain syndrome: correlation with gram positive bacterial growth and treatment response.
Pruritus
Relationships among plasma granzyme B level, pruritus and dermatitis in patients with atopic dermatitis.
Psoriasis
A comparative study of the expression of cytotoxic proteins in allergic contact dermatitis and psoriasis: spongiotic skin lesions in allergic contact dermatitis are highly infiltrated by T cells expressing perforin and granzyme B.
Psoriasis
Cytotoxic T lymphocytes as a potential brake of keratinocyte proliferation in psoriasis.
Psoriasis
Perforin and granzyme B may contribute to skin inflammation in atopic dermatitis and psoriasis.
Pulmonary Arterial Hypertension
Epsin15 Homology Domains: Role in the Pathogenesis of Pulmonary Arterial Hypertension.
Pulmonary Arterial Hypertension
Granzyme B deficiency promotes osteoblastic differentiation and calcification of vascular smooth muscle cells in hypoxic pulmonary hypertension.
Pulmonary Disease, Chronic Obstructive
A possible role for CD8(+) and non-CD8(+) cell granzyme B in early small airway wall remodeling in centrilobular emphysema.
Pulmonary Disease, Chronic Obstructive
Enhanced cytotoxic function of natural killer and natural killer T-like cells associated with decreased CD94 (Kp43) in the chronic obstructive pulmonary disease airway.
Pulmonary Disease, Chronic Obstructive
Enhanced effector function of cytotoxic cells in the induced sputum of COPD patients.
Pulmonary Disease, Chronic Obstructive
Increased airway granzyme b and perforin in current and ex-smoking COPD subjects.
Pulmonary Disease, Chronic Obstructive
Increased CD8 T-cell granzyme B in COPD is suppressed by treatment with low-dose azithromycin.
Pulmonary Disease, Chronic Obstructive
Role of increased CD8/CD28(null) T cells and alternative co-stimulatory molecules in chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Targeting peripheral blood pro-inflammatory cytotoxic lymphocytes by inhibiting CD137 expression: novel potential treatment for COPD.
Pulmonary Disease, Chronic Obstructive
The drug efflux pump Pgp1 in pro-inflammatory lymphocytes is a target for novel treatment strategies in COPD.
Pulmonary Disease, Chronic Obstructive
The effects of BAFF on T lymphocytes in chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
The possible role of granzyme B in the pathogenesis of chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
The Role of Granzyme B Containing Cells in the Progression of Chronic Obstructive Pulmonary Disease.
Pulmonary Emphysema
A possible role for CD8(+) and non-CD8(+) cell granzyme B in early small airway wall remodeling in centrilobular emphysema.
Pulmonary Fibrosis
Subset-specific alterations in frequencies and functional signatures of ?? T cells in systemic sclerosis patients.
Renal Insufficiency, Chronic
Plasma granzyme B as a predicting factor of coronary artery disease-Clinical significance in patients with chronic renal failure.
Retinitis
ZIKA virus infection causes persistent chorioretinal lesions.
Salmonella Infections
MHC class-I-restricted CD8 T cells play a protective role during primary Salmonella infection.
Sarcoma
Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes.
Sarcoma
Normalization of tumor microenvironment by neem leaf glycoprotein potentiates effector T cell functions and therapeutically intervenes in the growth of mouse sarcoma.
Schistosomiasis
Activation-induced T helper cell death contributes to Th1/Th2 polarization following murine Schistosoma japonicum infection.
Scleroderma, Systemic
Recognition of Granzyme B-generated autoantigen fragments in scleroderma patients with ischemic digital loss.
Sepsis
Notch signaling pathway regulates T cell dysfunction in septic patients.
Sepsis
Platelets Induce Apoptosis during Sepsis in a Contact-Dependent Manner That Is Inhibited by GPIIb/IIIa Blockade.
Sepsis
Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity.
Sepsis
Upregulation of two death pathways of perforin/granzyme and FasL/Fas in septic acute respiratory distress syndrome.
Shock, Septic
Notch signaling pathway regulates T cell dysfunction in septic patients.
Skin Diseases
Granzyme B as a therapeutic target for wound healing.
Small Cell Lung Carcinoma
Frequent T cell responses against immunogenic targets in lung cancer patients for targeted immunotherapy.
Spinal Cord Injuries
Granzyme-b mediated cell death in the spinal cord-injured rat model.
Spondylarthropathies
Raised granzyme B levels are associated with erosions in patients with early rheumatoid factor positive rheumatoid arthritis.
Squamous Cell Carcinoma of Head and Neck
Correlation of P53 and Granzyme B expression in Oral Squamous Cell Carcinoma with Clinicopathologic Findings.
Squamous Cell Carcinoma of Head and Neck
Distinct expression of perforin and granzyme B in lip and oral cavity squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Granzyme B-truncated VEGF fusion protein represses angiogenesis and tumor growth of OSCC.
Squamous Cell Carcinoma of Head and Neck
The clinicopathological significance of the expression of Granzyme B in oral squamous cell carcinoma.
ST Elevation Myocardial Infarction
Plasma granzyme B in ST elevation myocardial infarction versus non-ST elevation acute coronary syndrome: comparisons with IL-18 and fractalkine.
Stevens-Johnson Syndrome
Diagnostic Tools and Biomarkers for Severe Drug Eruptions.
Stevens-Johnson Syndrome
Phenotypic diversity in delayed drug hypersensitivity: an immunologic explanation.
Stomach Neoplasms
Exploitation of interleukin-18 by gastric cancers for their growth and evasion of host immunity.
Stomach Neoplasms
Intratumoral CD103+CD4+ T cell infiltration defines immunoevasive contexture and poor clinical outcomes in gastric cancer patients.
Stomach Neoplasms
[Mechanistic study of nimesulide on enhancing gammadeltaT cell-mediated killing of gastric cancer cells.]
Stroke
Role of Cytotoxic Protease Granzyme-b in Neuronal Degeneration during Human Stroke.
Subacute Sclerosing Panencephalitis
Granzyme B gene polymorphism associated with subacute sclerosing panencephalitis.
Synovitis
Monoclonal anti-CD8 therapy induces disease amelioration in the K/BxN mouse model of spontaneous chronic polyarthritis.
Teratocarcinoma
Apoptosis of the teratocarcinoma cell line Tera-1 leads to the cleavage of HERV-K10gag proteins by caspases and/or granzyme B.
Teratoma
EGFR806-CAR T cells selectively target a tumor-restricted EGFR epitope in glioblastoma.
Tetanus
Characterisation of immune responses in healthy foals when a multivalent vaccine protocol was initiated at age 90 or 180 days.
Tetanus
Identification of a potent regulatory T cell epitope in factor V that modulates CD4+ and CD8+ memory T cell responses.
Tetanus
Presentation of soluble antigens to CD8+ T cells by CpG oligodeoxynucleotide-primed human naive B cells.
Thyroiditis
Association of increased eomesodermin, BCL6, and granzyme B expression with major clinical manifestations of Hashimoto's thyroiditis - an observational study.
Thyroiditis
Expression of CD40 and apoptosis related molecules in autoimmune thyroid diseases.
Tonsillitis
Spatially visualized single-cell pathology of highly multiplexed protein profiles in health and disease.
Tuberculosis
Distinct functions of CXCR3+ and CCR4+CD4+ T-cells accumulated in human tuberculosis pleural fluid.
Tuberculosis
Granzyme B as a diagnostic marker of tuberculosis in patients with and without HIV coinfection.
Tuberculosis
Granzyme B Attenuates Bacterial Virulence by Targeting Secreted Factors.
Tuberculosis
Granzyme B Disrupts Central Metabolism and Protein Synthesis in Bacteria to Promote an Immune Cell Death Program.
Tuberculosis
Granzyme B induced by Rv0140 antigen discriminates latently infected from active tuberculosis individuals.
Tuberculosis
Granzyme B-expressing neutrophils correlate with bacterial load in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques.
Tuberculosis
Rat CD4+CD8+ Macrophages Kill Tumor Cells through an NKG2D- and Granzyme/Perforin-Dependent Mechanism.
Typhoid Fever
Expression of intra- and extracellular granzymes in patients with typhoid fever.
Urinary Bladder Neoplasms
Anaplastic lymphoma kinase-positive anaplastic large cell lymphoma presenting as a bladder neoplasm.
Urinary Bladder Neoplasms
Docosahexaenoic acid inhibits invasion of human RT112 urinary bladder and PT45 pancreatic carcinoma cells via down-modulation of granzyme B expression.
Uterine Cervical Neoplasms
A reversed CD4/CD8 ratio of tumor-infiltrating lymphocytes and a high percentage of CD4(+)FOXP3(+) regulatory T cells are significantly associated with clinical outcome in squamous cell carcinoma of the cervix.
Uterine Cervical Neoplasms
Blockade of BAFF Receptor BR3 on T Cells Enhances Their Activation and Cytotoxicity.
Uterine Cervical Neoplasms
Targeted biological effect of an affitoxin composed of an HPV16E7 affibody fused with granzyme B (ZHPV16E7-GrB) against cervical cancer in vitro and in vivo.
Vaccinia
Augmented replicative capacity of the boosting antigen improves the protective efficacy of heterologous prime-boost vaccine regimens.
Vaccinia
Differential regulation of granzyme and perforin in effector and memory T cells following smallpox immunization.
Vaccinia
Granzyme B inhibits vaccinia virus production through proteolytic cleavage of eukaryotic initiation factor 4 gamma 3.
Vascular Calcification
Granzyme B deficiency promotes osteoblastic differentiation and calcification of vascular smooth muscle cells in hypoxic pulmonary hypertension.
Vascular Diseases
Granzyme B in atherosclerosis and transplant vascular disease: association with cell death and atherosclerotic disease severity.
Vascular Diseases
Granzyme B induces endothelial cell apoptosis and contributes to the development of transplant vascular disease.
Vascular Diseases
Granzyme B induces smooth muscle cell apoptosis in the absence of perforin: involvement of extracellular matrix degradation.
Vasculitis
Histologic and Immunohistochemical Evaluation of Infiltrating Inflammatory Cells in Kawasaki Disease Arteritis Lesions.
Vasculitis
Serum granzyme B is associated with otorhinolaryngological, pulmonary, and renal involvement of antineutrophil cytoplasmic antibody-associated vasculitis.
Vesicular Stomatitis
Granzyme B independently of perforin mediates noncytolytic intracellular inactivation of vesicular stomatitis virus.
Viremia
Balance between activation and regulation of HIV-specific CD8+ T-cell response after modified vaccinia Ankara B therapeutic vaccination.
Virus Diseases
A natural genetic variant of granzyme B confers lethality to a common viral infection.
Virus Diseases
A triple-mutated allele of granzyme B incapable of inducing apoptosis.
Virus Diseases
Activating KIR copy number variation is associated with granzyme B release by NK cells during primary simian immunodeficiency virus infection in rhesus monkeys.
Virus Diseases
Antigenic Re-Stimulation of Virus-Specific Memory CD8+ T Cells Requires Days of Lytic Protein Accumulation for Maximal Cytotoxic Capacity.
Virus Diseases
Apoptosis of lymphocytes and monocytes infected with influenza virus might be the mechanism of combating virus and causing secondary infection by influenza.
Virus Diseases
Assessment of markers of the cell-mediated immune response after influenza virus infection in frail older adults.
Virus Diseases
CD8+CD57+ T cells exhibit distinct features in human non-small cell lung cancer.
Virus Diseases
Chronic HIV infection affects the expression of the 2 transcription factors required for CD8 T-cell differentiation into cytolytic effectors.
Virus Diseases
Control of lymphocytic choriomeningitis virus infection in granzyme B deficient mice.
Virus Diseases
Cutting edge: Persistently open chromatin at effector gene loci in resting memory CD8+ T cells independent of transcriptional status.
Virus Diseases
CXCR3 deficiency increases susceptibility to genital herpes simplex virus type 2 infection: Uncoupling of CD8+ T-cell effector function but not migration.
Virus Diseases
Dok-1 and Dok-2 Regulate the Formation of Memory CD8+ T Cells.
Virus Diseases
Frequency, specificity, and sites of expansion of CD8+ T cells during primary pulmonary influenza virus infection.
Virus Diseases
Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A.
Virus Diseases
Granzyme B regulates antiviral CD8+ T cell responses.
Virus Diseases
Granzymes and caspase 3 play important roles in control of gammaherpesvirus latency.
Virus Diseases
Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies.
Virus Diseases
Highly differentiated, resting gn-specific memory CD8+ T cells persist years after infection by andes hantavirus.
Virus Diseases
Independence of Granzyme B Secretion and Interferon- gamma Production during Acute Simian Immunodeficiency Virus Infection.
Virus Diseases
IRF3 deficiency impacts granzyme B expression and maintenance of memory T cell function in response to viral infection.
Virus Diseases
Isolation and characterization of novel single-chain Fv specific for human granzyme B.
Virus Diseases
Local blockade of epithelial PDL-1 in the airways enhances T cell function and viral clearance during influenza virus infection.
Virus Diseases
Properties of murine (CD8+)CD27- T cells.
Virus Diseases
Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection.
Virus Diseases
Selective expansion of a peripheral blood CD8+ memory T cell subset expressing both granzyme B and L-selectin during primary viral infection in renal allograft recipients.
Virus Diseases
Suppressed expression of miR-378 targeting gzmb in NK cells is required to control dengue virus infection.
Virus Diseases
The innate antiviral immune system of the cat: Molecular tools for the measurement of its state of activation.
Vitiligo
A similar local immune and oxidative stress phenotype in vitiligo and halo nevus.
Vitiligo
Genetic polymorphisms of GZMB and vitiligo: A genetic association study based on Chinese Han population.
Vitiligo
The Role of TRM Cells in the Pathogenesis of Vitiligo-A Review of the Current State-Of-The-Art.
Vitiligo
Tissue-resident memory T cells in the skin.
West Nile Fever
Correlation of Regulatory T Cell Numbers with Disease Tolerance upon Virus Infection.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Odake, S.; Kam, C.M.; Narasimhan, L.; Poe, M.; Blake, J.T.; Krahenbuhl, O.; Tschopp, J.; Powers, J.C.
Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins
Biochemistry
30
2217-2227
1991
Homo sapiens, Mus musculus
brenda
Schmid, J.; Weissmann, C.
Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes
J. Immunol.
139
250-259
1987
Homo sapiens
brenda
Poe, M.; Blake, J.T.; Boulton, D.A.; Gammon, M.; Sigal, N.H.; Wu, J.K.; Zweerink, H.J.
Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity
J. Biol. Chem.
266
98-103
1991
Homo sapiens
brenda
Peitsch, M.C.; Tschopp, J.
Granzyme B
Methods Enzymol.
244
80-87
1994
Homo sapiens, Mus musculus
brenda
Trapani, J.A.; Browne, K.A.; Dawson, M.; Smyth, M.J.
Immunopurification of functional Asp-ase (natural killer cell granzyme B) using a monoclonal antibody
Biochem. Biophys. Res. Commun.
195
910-920
1993
Homo sapiens
brenda
Darmon, A.J.; Nicholson, D.W.; Bleackley, C.
Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B
Nature
377
446-448
1995
Homo sapiens
brenda
Smyth, M.J.; McGuire, M.J.; Thia, K.Y.T.
Expression of recombinant human granzyme B. A processing and activation role for dipeptidyl peptidase I
J. Immunol.
154
6299-6305
1995
Homo sapiens
brenda
Gu, Y.; Sarnecki, C.; Fleming, M.A.; Lippke, J.A.; Bleackley, R.C.; Su, M.S.S.
Processing and activation of CMH-1 by granzyme B
J. Biol. Chem.
271
10816-10820
1996
Homo sapiens
brenda
Quan, L.T.; Tewari, M.; O'Rourke, K.; Dixit, V.; Snipas, S.J.; Poirier, G.G.; Ray, C.; Pickup, D.J.; Salvesen, G.S.
Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B
Proc. Natl. Acad. Sci. USA
93
1972-1976
1996
Homo sapiens
brenda
Xia, Z.; Kam, C.M.; Huang, C.; Powers, J.C.; Mandle, R.J.; Stevens, R.L.; Lieberman, J.
Expression and purification of enzymatically active recombinant granzyme B in a baculovirus system
Biochem. Biophys. Res. Commun.
243
384-389
1998
Homo sapiens, Mus musculus
brenda
Sun, J.; Bird, C.H.; Buzza, M.S.; McKee, K.E.; Whisstock, J.C.; Bird, P.I.
Expression and purification of recombinant human granzyme B from Pichia pastoris
Biochem. Biophys. Res. Commun.
261
251-255
1999
Homo sapiens
brenda
Estebanez-Perpina, E.; Fuentes-Prior, P.; Belorgey, D.; Braun, M.; Kiefersauer, R.; Maskos, K.; Huber, R.; Rubin, H.; Bode, W.
Crystal structure of the caspase activator human granzyme B, a proteinase highly specific for an Asp-P1 residue
Biol. Chem.
381
1203-1214
2000
Homo sapiens
brenda
Rotonda, J.; Garcia-Calvo, M.; Bull, H.G.; Geissler, W.M.; McKeever, B.M.; Willoughby, C.A.; Thornberry, N.A.; Becker, J.W.
The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1
Chem. Biol.
8
357-368
2001
Homo sapiens
brenda
Andrade, F.; Roy, S.; Nicholson, D.; Thornberry, N.; Rosen, A.; Casciola-Rosen, L.
Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis
Immunity
8
451-460
1998
Homo sapiens
brenda
Kanamori, H.; Krieg, S.; Mao, C.; Di Pippo, V.A.; Wang, S.; Zajchowski, D.A.; Shapiro, D.J.
Proteinase inhibitor 9, an inhibitor of granzyme B-mediated apoptosis, is a primary estrogen-inducible gene in human liver cells
J. Biol. Chem.
275
5867-5873
2000
Homo sapiens
brenda
Sun, J.; Whisstock, J.C.; Harriott, P.; Walker, B.; Novak, A.; Thompson, P.E.; Smith, A.I.; Bird, P.I.
Importance of the P4' residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the proteinase inhibitor 9 reactive center loop
J. Biol. Chem.
276
15177-15184
2001
Homo sapiens
brenda
Shi, L.; Yang, X.; Froelich, C.J.; Greenberg, A.H.
Purification and use of granzyme B
Methods Enzymol.
322
125-143
2000
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Andrade, F.; Casciola-Rosen, L.A.; Rosen, A.
A novel domain in adenovirus L4-100K is required for stable binding and efficient inhibition of human granzyme B: possible interaction with a species-specific exosite
Mol. Cell. Biol.
23
6315-6326
2003
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Giesuebel, U.; Daelken, B.; Mahmud, H.; Wels, W.S.
Cell binding, internalization and cytotoxic activity of human granzyme B expressed in the yeast Pichia pastoris
Biochem. J.
394
563-573
2006
Homo sapiens
brenda
Grossman, W.J.; Verbsky, J.W.; Tollefsen, B.L.; Kemper, C.; Atkinson, J.P.; Ley, T.J.
Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells
Blood
104
2840-2848
2004
Homo sapiens
brenda
Mahrus, S.; Craik, C.S.
Selective chemical functional probes of granzymes A and B reveal granzyme B Is a major effector of natural killer cell-mediated lysis of target cells
Chem. Biol.
12
567-577
2005
Homo sapiens
brenda
Sun, J.; Bird, C.H.; Thia, K.Y.; Matthews, A.Y.; Trapani, J.A.; Bird, P.I.
Granzyme B encoded by the commonly occurring human RAH allele retains pro-apoptotic activity
J. Biol. Chem.
279
16907-16911
2004
Homo sapiens
brenda
Loeb, C.R.; Harris, J.L.; Craik, C.S.
Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance towards apoptosis
J. Biol. Chem.
281
28326-28335
2006
Homo sapiens
brenda
Blink, E.J.; Jiansheng, Z.; Hu, W.; Calanni, S.T.; Trapani, J.A.; Bird, P.I.; Jans, D.A.
Interaction of the nuclear localizing cytolytic granule serine protease granzyme B with importin alpha or beta: modulation by the serpin inhibitor PI-9
J. Cell. Biochem.
95
598-610
2005
Homo sapiens
brenda
Lorentsen, R.H.; Fynbo, C.H.; Thogersen, H.C.; Etzerodt, M.; Holtet, T.L.
Expression, refolding, and purification of recombinant human granzyme B
Protein Expr. Purif.
39
18-26
2005
Homo sapiens
brenda
Kuerten, S.; Nowacki, T.M.; Kleen, T.O.; Asaad, R.J.; Lehmann, P.V.; Tary-Lehmann, M.
Dissociated production of perforin, granzyme B, and IFN-gamma by HIV-specific CD8(+) cells in HIV infection
AIDS Res. Hum. Retroviruses
24
62-71
2008
Homo sapiens
brenda
Fellows, E.; Gil-Parrado, S.; Jenne, D.E.; Kurschus, F.C.
Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program
Blood
110
544-552
2007
Homo sapiens
brenda
Chamberlain, C.M.; Granville, D.J.
The role of Granzyme B in atheromatous diseases
Can. J. Physiol. Pharmacol.
85
89-95
2007
Homo sapiens, Mus musculus
brenda
Nowacki, T.M.; Kuerten, S.; Zhang, W.; Shive, C.L.; Kreher, C.R.; Boehm, B.O.; Lehmann, P.V.; Tary-Lehmann, M.
Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells
Cell. Immunol.
247
36-48
2007
Homo sapiens
brenda
Andrade, F.; Fellows, E.; Jenne, D.E.; Rosen, A.; Young, C.S.
Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition
EMBO J.
26
2148-2157
2007
Homo sapiens
brenda
Bredemeyer, A.J.; Carrigan, P.E.; Fehniger, T.A.; Smith, D.F.; Ley, T.J.
Hop cleavage and function in granzyme B-induced apoptosis
J. Biol. Chem.
281
37130-37141
2006
Homo sapiens, Mus musculus
brenda
Hostetter, D.R.; Loeb, C.R.; Chu, F.; Craik, C.S.
Hip is a pro-survival substrate of granzyme B
J. Biol. Chem.
282
27865-27874
2007
Homo sapiens
brenda
Meslin, F.; Thiery, J.; Richon, C.; Jalil, A.; Chouaib, S.
Granzyme B-induced cell death involves induction of p53 tumor suppressor gene and its activation in tumor target cells
J. Biol. Chem.
282
32991-32999
2007
Homo sapiens
brenda
Casciola-Rosen, L.; Garcia-Calvo, M.; Bull, H.G.; Becker, J.W.; Hines, T.; Thornberry, N.A.; Rosen, A.
Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway
J. Biol. Chem.
282
4545-4552
2007
Homo sapiens, Mus musculus
brenda
Cullen, S.P.; Adrain, C.; Luethi, A.U.; Duriez, P.J.; Martin, S.J.
Human and murine granzyme B exhibit divergent substrate preferences
J. Cell Biol.
176
435-444
2007
Homo sapiens, Mus musculus
brenda
Goping, I.S.; Sawchuk, T.; Underhill, D.A.; Bleackley, R.C.
Identification of alpha-tubulin as a granzyme B substrate during CTL-mediated apoptosis
J. Cell Sci.
119
858-865
2006
Homo sapiens
brenda
Ammar, M.; Mokni, M.; Boubaker, S.; El Goaied, A.; Ben Osman, A.; Louzir, H.
Involvement of granzyme B and granulysin in the cytotoxic response in lichen planus
J. Cutan. Pathol.
35
630-634
2008
Homo sapiens
brenda
Packard, B.Z.; Telford, W.G.; Komoriya, A.; Henkart, P.A.
Granzyme B activity in target cells detects attack by cytotoxic lymphocytes
J. Immunol.
179
3812-3820
2007
Homo sapiens
brenda
Batinac, T.; Zamolo, G.; Coklo, M.; Hadzisejdic, I.
Possible key role of granzyme B in keratoacanthoma regression
Med. Hypotheses
66
1129-1132
2006
Homo sapiens
brenda
Strik, M.C.; de Koning, P.J.; Kleijmeer, M.J.; Bladergroen, B.A.; Wolbink, A.M.; Griffith, J.M.; Wouters, D.; Fukuoka, Y.; Schwartz, L.B.; Hack, C.E.; van Ham, S.M.; Kummer, J.A.
Human mast cells produce and release the cytotoxic lymphocyte associated protease granzyme B upon activation
Mol. Immunol.
44
3462-3472
2007
Homo sapiens
brenda
Hou, Q.; Zhao, T.; Zhang, H.; Lu, H.; Zhang, Q.; Sun, L.; Fan, Z.
Granzyme H induces apoptosis of target tumor cells characterized by DNA fragmentation and Bid-dependent mitochondrial damage
Mol. Immunol.
45
1044-1055
2008
Homo sapiens
brenda
Morissette, M.C.; Parent, J.; Milot, J.
Perforin, granzyme B, and FasL expression by peripheral blood T lymphocytes in emphysema
Respir. Res.
8
62
2007
Homo sapiens
brenda
Waterhouse, N.J.; Trapani, J.A.
H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells
Trends Immunol.
28
373-375
2007
Homo sapiens, Mus musculus
brenda
Piuko, K.; Bravo, I.G.; Mueller, M.
Identification and characterization of equine granzyme B
Vet. Immunol. Immunopathol.
118
239-251
2007
Homo sapiens, Equus caballus (Q2A6L4), Equus caballus
brenda
Freishtat, R.J.; Natale, J.; Benton, A.S.; Cohen, J.; Sharron, M.; Wiles, A.A.; Ngor, W.M.; Mojgani, B.; Bradbury, M.; Degnan, A.; Sachdeva, R.; Debiase, L.M.; Ghimbovschi, S.; Chow, M.; Bunag, C.; Kristosturyan, E.; Hoffman, E.P.
Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity
Am. J. Respir. Crit. Care Med.
179
467-473
2009
Homo sapiens, Mus musculus
brenda
Besenicar, M.P.; Metkar, S.; Wang, B.; Froelich, C.J.; Anderluh, G.
Granzyme B translocates across the lipid membrane only in the presence of lytic agents
Biochem. Biophys. Res. Commun.
371
391-394
2008
Homo sapiens
brenda
Romero, V.; Fellows, E.; Jenne, D.E.; Andrade, F.
Cleavage of La protein by granzyme H induces cytoplasmic translocation and interferes with La-mediated HCV-IRES translational activity
Cell Death Differ.
16
340-348
2009
Homo sapiens
brenda
Nishimura, M.; Sato, H.; Okazaki, H.; Satake, M.; Tadokoro, K.
Interleukin-10 containing normal human serum inhibits granzyme B release but not perforin release from alloreactive and EBV-specific T cell clones
Cell. Immunol.
251
31-36
2008
Homo sapiens
brenda
Kondo, H.; Hojo, Y.; Tsuru, R.; Nishimura, Y.; Shimizu, H.; Takahashi, N.; Hirose, M.; Ikemoto, T.; Ohya, K.; Katsuki, T.; Yashiro, T.; Shimada, K.
Elevation of plasma granzyme B levels after acute myocardial infarction
Circ. J.
73
503-507
2009
Homo sapiens
brenda
Takahashi, Y.; Mine, J.; Kubota, Y.; Yamazaki, E.; Fujiwara, T.
A substantial number of Rasmussen syndrome patients have increased IgG, CD4(+) T cells, TNFalpha, and granzyme B in CSF
Epilepsia
50
1419-1431
2009
Homo sapiens
brenda
Prakash, M.D.; Bird, C.H.; Bird, P.I.
Active and zymogen forms of granzyme B are constitutively released from cytotoxic lymphocytes in the absence of target cell engagement
Immunol. Cell Biol.
87
249-254
2009
Homo sapiens
brenda
Bratke, K.; Goettsching, H.; Kuepper, M.; Geyer, S.; Luttmann, W.; Virchow, J.C.
Interleukin-4 suppresses the cytotoxic potential of in vitro generated, adaptive regulatory CD4(+) T cells by down-regulation of granzyme B
Immunology
127
338-344
2008
Homo sapiens
brenda
Buzza, M.S.; Dyson, J.M.; Choi, H.; Gardiner, E.E.; Andrews, R.K.; Kaiserman, D.; Mitchell, C.A.; Berndt, M.C.; Dong, J.F.; Bird, P.I.
Antihemostatic activity of human granzyme B mediated by cleavage of von Willebrand factor
J. Biol. Chem.
283
22498-22504
2008
Homo sapiens
brenda
Araki, Y.; Fann, M.; Wersto, R.; Weng, N.P.
Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules (eomesodermin and its targets: perforin and granzyme B)
J. Immunol.
180
8102-8108
2008
Homo sapiens
brenda
Chattopadhyay, P.K.; Betts, M.R.; Price, D.A.; Gostick, E.; Horton, H.; Roederer, M.; De Rosa, S.C.
The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression
J. Leukoc. Biol.
85
88-97
2009
Homo sapiens
brenda
Casciola-Rosen, L.; Miagkov, A.; Nagaraju, K.; Askin, F.; Jacobson, L.; Rosen, A.; Drachman, D.B.
Granzyme B: evidence for a role in the origin of myasthenia gravis
J. Neuroimmunol.
201-202
33-40
2008
Homo sapiens
brenda
Van Damme, P.; Maurer-Stroh, S.; Plasman, K.; Van Durme, J.; Colaert, N.; Timmerman, E.; De Bock, P.J.; Goethals, M.; Rousseau, F.; Schymkowitz, J.; Vandekerckhove, J.; Gevaert, K.
Analysis of protein processing by N-terminal proteomics reveals novel species-specific substrate determinants of granzyme B orthologs
Mol. Cell. Proteomics
8
258-272
2009
Homo sapiens, Mus musculus
brenda
Jahrsdoerfer, B.; Vollmer, A.; Blackwell, S.E.; Maier, J.; Sontheimer, K.; Beyer, T.; Mandel, B.; Lunov, O.; Tron, K.; Nienhaus, G.U.; Simmet, T.; Debatin, K.M.; Weiner, G.J.; Fabricius, D.
Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion
Blood
115
1156-1165
2010
Homo sapiens
brenda
Thiery, J.; Keefe, D.; Saffarian, S.; Martinvalet, D.; Walch, M.; Boucrot, E.; Kirchhausen, T.; Lieberman, J.
Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis
Blood
115
1582-1593
2010
Homo sapiens
brenda
Efimova, O.V.; Kelley, T.W.
Induction of granzyme B expression in T-cell receptor/CD28-stimulated human regulatory T cells is suppressed by inhibitors of the PI3K-mTOR pathway
BMC Immunol.
10
59
2009
Homo sapiens
brenda
Darrah, E.; Rosen, A.
Granzyme B cleavage of autoantigens in autoimmunity
Cell Death Differ.
17
624-632
2010
Homo sapiens
brenda
Xie, D.; Hai, B.; Xie, X.; Liu, L.; Ayello, J.; Ma, X.; Zhang, J.
Peripheral CD4+CD8+cells are the activated T cells expressed granzyme B (GrB), Foxp3, interleukin 17 (IL-17), at higher levels in Th1/Th2 cytokines
Cell. Immunol.
259
157-164
2009
Homo sapiens
brenda
Li, P.; Zheng, G.; Yang, Y.; Zhang, C.; Xiong, P.; Xu, Y.; Fang, M.; Tan, Z.; Zheng, F.; Gong, F.
Granzyme B is recovered by natural killer cells via clathrin-dependent endocytosis
Cell. Mol. Life Sci.
67
3197-3208
2010
Homo sapiens
brenda
Grassi, M.; Capello, F.; Bertolino, L.; Seia, Z.; Pippione, M.
Identification of granzyme B-expressing CD-8-positive T cells in lymphocytic inflammatory infiltrate in cutaneous lupus erythematosus and in dermatomyositis
Clin. Exp. Dermatol.
34
910-914
2009
Homo sapiens
brenda
Hodge, S.; Hodge, G.; Ahern, J.; Liew, C.L.; Hopkins, P.; Chambers, D.C.; Reynolds, P.N.; Holmes, M.
Increased levels of T cell granzyme b in bronchiolitis obliterans syndrome are not suppressed adequately by current immunosuppressive regimens
Clin. Exp. Immunol.
158
230-236
2009
Homo sapiens
brenda
Hagn, M.; Ebel, V.; Sontheimer, K.; Schwesinger, E.; Lunov, O.; Beyer, T.; Fabricius, D.; Barth, T.F.; Viardot, A.; Stilgenbauer, S.; Hepp, J.; Scharffetter-Kochanek, K.; Simmet, T.; Jahrsdoerfer, B.
CD5(+) B cells from individuals with systemic lupus erythematosus express granzyme B
Eur. J. Immunol.
40
2060-2069
2010
Homo sapiens
brenda
Kurschus, F.; Jenne, D.
Delivery and therapeutic potential of human granzyme B
Immunol. Rev.
235
159-171
2010
Homo sapiens, Mus musculus
brenda
D'Eliseo, D.; Pisu, P.; Romano, C.; Tubaro, A.; De Nunzio, C.; Morrone, S.; Santoni, A.; Stoppacciaro, A.; Velotti, F.
Granzyme B is expressed in urothelial carcinoma and promotes cancer cell invasion
Int. J. Cancer
127
1283-1294
2009
Homo sapiens
brenda
D'Angelo, M.E.; Bird, P.I.; Peters, C.; Reinheckel, T.; Trapani, J.A.; Sutton, V.R.
Cathepsin H is an additional convertase of pro-granzyme B
J. Biol. Chem.
285
20514-20519
2010
Homo sapiens, Mus musculus
brenda
Wang, T.; Lee, M.H.; Johnson, T.; Allie, R.; Hu, L.; Calabresi, P.A.; Nath, A.
Activated T-cells inhibit neurogenesis by releasing granzyme B: rescue by Kv1.3 blockers
J. Neurosci.
30
5020-5027
2010
Homo sapiens
brenda
Boivin, W.A.; Cooper, D.M.; Hiebert, P.R.; Granville, D.J.
Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma
Lab. Invest.
89
1195-1220
2009
Homo sapiens, Mus musculus
brenda
van Tetering, G.; Bovenschen, N.; Meeldijk, J.; van Diest, P.J.; Vooijs, M.
Cleavage of Notch1 by granzyme B disables its transcriptional activity
Biochem. J.
437
313-322
2011
Homo sapiens
brenda
Chaitanya, G.V.; Eeka, P.; Munker, R.; Alexander, J.S.; Babu, P.P.
Role of cytotoxic protease granzyme-b in neuronal degeneration during human stroke
Brain Pathol.
21
16-30
2011
Homo sapiens
brenda
Shah, D.; Kiran, R.; Wanchu, A.; Bhatnagar, A.
Soluble granzyme B and cytotoxic T lymphocyte activity in the pathogenesis of systemic lupus erythematosus
Cell. Immunol.
269
16-21
2011
Homo sapiens
brenda
Ilzecka, J.
Granzymes A and B levels in serum of patients with amyotrophic lateral sclerosis
Clin. Biochem.
44
650-653
2011
Homo sapiens
brenda
Afonina, I.; Cullen, S.; Martin, S.
Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B
Immunol. Rev.
235
105-116
2010
Homo sapiens
brenda
Omoto, Y.; Yamanaka, K.; Tokime, K.; Kitano, S.; Kakeda, M.; Akeda, T.; Kurokawa, I.; Gabazza, E.C.; Tsutsui, H.; Katayama, N.; Yamanishi, K.; Nakanishi, K.; Mizutani, H.
Granzyme B is a novel interleukin-18 converting enzyme
J. Dermatol. Sci.
59
129-135
2010
Homo sapiens
brenda
Gehrmann, M.; Doss, B.T.; Wagner, M.; Zettlitz, K.A.; Kontermann, R.E.; Foulds, G.; Pockley, A.G.; Multhoff, G.
A novel expression and purification system for the production of enzymatic and biologically active human granzyme B
J. Immunol. Methods
371
8-17
2011
Homo sapiens
brenda
Niland, B.; Miklossy, G.; Banki, K.; Biddison, W.E.; Casciola-Rosen, L.; Rosen, A.; Martinvalet, D.; Lieberman, J.; Perl, A.
Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients
J. Immunol.
184
4025-4032
2010
Homo sapiens
brenda
Haile, Y.; Simmen, K.C.; Pasichnyk, D.; Touret, N.; Simmen, T.; Lu, J.Q.; Bleackley, R.C.; Giuliani, F.
Granule-derived granzyme B mediates the vulnerability of human neurons to T cell-induced neurotoxicity
J. Immunol.
187
4861-4872
2011
Homo sapiens
brenda
Kapelski, S.; de Almeida, M.; Fischer, R.; Barth, S.; Fendel, R.
Antimalarial activity of granzyme B and its targeted delivery by a granzyme B-single-chain Fv fusion protein
Antimicrob. Agents Chemother.
59
669-672
2015
Homo sapiens (P10144)
brenda
Mellor-Heineke, S.; Villanueva, J.; Jordan, M.B.; Marsh, R.; Zhang, K.; Bleesing, J.J.; Filipovich, A.H.; Risma, K.A.
Elevated granzyme B in cytotoxic lymphocytes is a signature of immune activation in hemophagocytic lymphohistiocytosis
Front. Immunol.
4
72
2013
Homo sapiens (P10144), Homo sapiens
brenda
Bhela, S.; Kempsell, C.; Manohar, M.; Dominguez-Villar, M.; Griffin, R.; Bhatt, P.; Kivisakk-Webb, P.; Fuhlbrigge, R.; Kupper, T.; Weiner, H.; Baecher-Allan, C.
Nonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell (Treg) suppression by HLA-DR-CD25hiCD127lo tregs in multiple sclerosis and in response to IL-6
J. Immunol.
194
2180-2189
2015
Homo sapiens (P10144), Homo sapiens
brenda
Kim, M.S.; Buisson, L.A.; Heathcote, D.A.; Hu, H.; Braddock, D.C.; Barrett, A.G.; Ashton-Rickardt, P.G.; Snyder, J.P.
Approaches to design non-covalent inhibitors for human granzyme B (hGrB)
Org. Biomol. Chem.
12
8952-8965
2014
Homo sapiens (P10144), Homo sapiens
brenda
Boivin, W.A.; Shackleford, M.; Vanden Hoek, A.; Zhao, H.; Hackett, T.L.; Knight, D.A.; Granville, D.J.
Granzyme B cleaves decorin, biglycan and soluble betaglycan, releasing active transforming growth factor-beta1
PLoS ONE
7
e33163
2012
Homo sapiens (P10144)
brenda
Oberoi, P.; Jabulowsky, R.A.; Baehr-Mahmud, H.; Wels, W.S.
EGFR-targeted granzyme B expressed in NK cells enhances natural cytotoxicity and mediates specific killing of tumor cells
PLoS ONE
8
e61267
2013
Homo sapiens (P10144), Homo sapiens
brenda
Li, X.; Zhang, G.; An, G.; Liu, S.; Lai, Y.
Expression, purification and anticancer analysis of GST-tagged human perforin and granzyme B proteins in human laryngeal cancer Hep-2 cells
Protein Expr. Purif.
95
38-43
2014
Homo sapiens (P10144), Homo sapiens
brenda
Ho, P.; Ede, C.; Chen, Y.Y.
Modularly constructed synthetic granzyme B molecule enables interrogation of intracellular proteases for targeted cytotoxicity
ACS Synth. Biol.
6
1484-1495
2017
Homo sapiens (P10144), Homo sapiens
brenda
Kapelski, S.; De Almeida, M.; Fischer, R.; Barth, S.; Fendel, R.
Antimalarial activity of granzyme B and its targeted delivery by a granzyme B-single-chain Fv fusion protein
Antimicrob. Agents Chemother.
59
669-672
2015
Homo sapiens (P10144)
brenda
Dotiwala, F.; Sen Santara, S.; Binker-Cosen, A.A.; Li, B.; Chandrasekaran, S.; Lieberman, J.
Granzyme B disrupts central metabolism and protein synthesis in bacteria to promote an immune cell death program
Cell
171
1125-1137
2017
Homo sapiens (P10144), Homo sapiens
brenda
Kumar, A.; Perdomo, M.F.; Kantele, A.; Hedman, L.; Hedman, K.; Franssila, R.
Granzyme B mediated function of parvovirus B19-specific CD4+ T cells
Clin. Transl. Immunology
4
e39
2015
Homo sapiens (P10144)
brenda
Cimini, F.A.; DEliseo, D.; Barchetta, I.; Bertoccini, L.; Velotti, F.; Cavallo, M.G.
Increased circulating granzyme B in type 2 diabetes patients with low-grade systemic inflammation
Cytokine
115
104-108
2019
Homo sapiens (P10144), Homo sapiens
brenda
Darrah, E.; Kim, A.; Zhang, X.; Boronina, T.; Cole, R.N.; Fava, A.; Giles, J.T.; Bingham III, C.O.; Chalmers, M.J.; Griffin, P.R.; Sadegh-Nasseri, S.; Rosen, A.
Proteolysis by granzyme B enhances presentation of autoantigenic peptidylarginine deiminase 4 epitopes in rheumatoid arthritis
J. Proteome Res.
16
355-365
2017
Homo sapiens
brenda
Wang, L.; Jiang, S.; Xiao, L.; Chen, L.; Zhang, Y.; Tong, J.
Inhibition of granzyme B activity blocks inflammation induced by lipopolysaccharide through regulation of endoplasmic reticulum stress signaling in NK92 cells
Mol. Med. Rep.
18
580-586
2018
Homo sapiens (P10144)
brenda
Fu, Z.; Thorpe, M.; Akula, S.; Hellman, L.
Asp-ase activity of the Opossum granzyme B supports the role of granzyme B as part of anti-viral immunity already during early mammalian evolution
PLoS ONE
11
e0154886
2016
Monodelphis domestica, Homo sapiens (P10144), Homo sapiens
brenda
Marcet-Palacios, M.; Ewen, C.; Pittman, E.; Duggan, B.; Carmine-Simmen, K.; Fahlman, R.; Bleackley, R.
Design and characterization of a novel human granzyme B inhibitor
Protein Eng. Des. Sel.
28
9-17
2015
Homo sapiens (P10144), Homo sapiens
brenda
Shevtsov, M.; Stangl, S.; Nikolaev, B.; Yakovleva, L.; Marchenko, Y.; Tagaeva, R.; Sievert, W.; Pitkin, E.; Mazur, A.; Tolstoy, P.; Galibin, O.; Ryzhov, V.; Steiger, K.; Smirnov, O.; Khachatryan, W.; Chester, K.; Multhoff, G.
Granzyme B functionalized nanoparticles targeting membrane Hsp70-positive tumors for multimodal cancer theranostics
Small
15
e1900205
2019
Homo sapiens (P10144)
brenda