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Information on EC 3.4.21.75 - Furin and Organism(s) Gallus gallus

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.75 Furin
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This record set is specific for:
Gallus gallus
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Word Map
The taxonomic range for the selected organisms is: Gallus gallus
The enzyme appears in selected viruses and cellular organisms
Synonyms
furin, sheddase, prohormone convertase, furin a, furin protease, proconvertase, subtilisin-like proprotein convertase, furin-like protease, furin convertase, kpc-1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Dibasic processing enzyme
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-
-
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furin-like prohormone convertase
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PACE
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-
-
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Paired basic amino acid cleaving enzyme
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-
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Paired basic amino acid converting enzyme
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-
-
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Paired basic amino acid residue cleaving enzyme
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-
-
-
PC1
-
-
-
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prohormone convertase
Proprotein convertase
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-
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Serine proteinase PACE
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-
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SPC3
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Trans golgi network protease furin
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additional information
furin belongs to the family of proprotein convertase subtilisin/kexin type proteases
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
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CAS REGISTRY NUMBER
COMMENTARY hide
141760-45-4
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
avian influenza virus A hemagglutinin + H2O
?
show the reaction diagram
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from strain vian influenza virus, A/chicken/Israel/810/2001 (H9N2), with R-S-K-R cleavage site
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-
?
hepatitis B e antigen precursor + H2O
?
show the reaction diagram
-
furin can cleave the RRDR, RRGR, and RSPR motifs
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-
?
additional information
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
decanoyl-Arg-Val-Lys-Arg-chloromethylketone
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furin protease inhibitor, significantly diminishes secretion of S-tag-containing cysteine-rich FGF receptor products
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
trans-Golgi network
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
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furin is a member of the proprotein convertase family
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
Q91000_CHICK
789
0
86631
TrEMBL
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cDNA cloned into vector pAdTrack-CMV, followed by recombination in Escherichia coli cells with the adenovirus backbone pAdEasy-1, recombinant DNA transfected to HEK-293 cells. Introduction by adenovirus vector in LoVo cells
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DNA and amino acid sequence determination of neuropeptides and expression profiling, overview
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Antoine, M.; Koehl, R.; Tag, C.G.; Gressner, A.M.; Hellerbrand, C.; Kiefer, P.
Secreted cysteine-rich FGF receptor derives from posttranslational processing by furin-like prohormone convertases
Biochem. Biophys. Res. Commun.
382
359-364
2009
Gallus gallus
Manually annotated by BRENDA team
Ito, K.; Kim, K.H.; Lok, A.S.; Tong, S.
Characterization of genotype-specific carboxyl-terminal cleavage sites of hepatitis B virus e antigen precursor and identification of furin as the candidate enzyme
J. Virol.
83
3507-3517
2009
Gallus gallus, Homo sapiens
Manually annotated by BRENDA team
Delfino, K.R.; Southey, B.R.; Sweedler, J.V.; Rodriguez-Zas, S.L.
Genome-wide census and expression profiling of chicken neuropeptide and prohormone convertase genes
Neuropeptides
44
31-44
2010
Gallus gallus (Q91000), Gallus gallus
Manually annotated by BRENDA team
Tse, L.V.; Hamilton, A.M.; Friling, T.; Whittaker, G.R.
A novel activation mechanism of avian influenza virus H9N2 by furin
J. Virol.
88
1673-1683
2014
Gallus gallus, Homo sapiens (P09958), Homo sapiens
Manually annotated by BRENDA team