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C2 fragment + H2O
?
-
C-terminal fragment originating from the processing of meningococcal proteases
-
-
?
complement component C3 + H2O
complement component C3a + complement component C3b
complement component C3 zymogen + H2O
complement component C3b + complement component C3a
complement component C5 + H2O
complement component C5a + complement component C5b
complement component C5 zymogen + H2O
complement component C5b + complement component C5a
neisserial heparin binding antigen + H2O
?
-
also known as GNA2132 (genome-derived Neisseria antigen 2132)
-
-
?
t-butyloxycarbonyl-Gly-L-Leu-L-Ala-L-Arg-thiobenzyl ester
?
substrate of enzyme subunit Bb
-
-
?
tert-butoxycarbonyl-Leu-Gly-Arg-7-amido-4-methylcoumarin + H2O
tert-butoxycarbonyl-Leu-Gly-Arg + 7-amino-4-methylcoumarin
-
-
-
?
tert-butoxycarbonyl-norleucine-Gln-Leu-Gly-Arg-7-amido-4-methylcoumarin + H2O
tert-butoxycarbonyl-norleucine-Gln-Leu-Gly-Arg + 7-amino-4-methylcoumarin
-
-
-
?
additional information
?
-
complement component C3 + H2O
complement component C3a + complement component C3b
-
-
-
?
complement component C3 + H2O
complement component C3a + complement component C3b
-
-
-
-
?
complement component C3 + H2O
complement component C3a + complement component C3b
-
-
-
?
complement component C3 + H2O
complement component C3a + complement component C3b
-
-
-
-
?
complement component C3 + H2O
complement component C3a + complement component C3b
-
-
-
?
complement component C3 + H2O
complement component C3a + complement component C3b
-
hydrolysis of peptide bond 77 Arg-Ser of the a-chain
-
?
complement component C3 + H2O
complement component C3a + complement component C3b
-
complement component C3 is the preferred substrate. Cleavage of the preferred C3 substrate and deposition of C3b effectively switches the output of the enzyme from C3b to C5b, resulting in initiation of the cytosolic process of complement
-
?
complement component C3 + H2O
complement component C3a + complement component C3b
analysis of structure and function of complement component C3b in complex with the macrophage-expressed complement receptor CRIg, CRIg shown as an inhibitor of alternative complement convertases
-
-
?
complement component C3 + H2O
complement component C3a + complement component C3b
cleavage of complement component C3 mediated through the MBL pathway in human serum analyzed, mannan-binding lectin (MBL) promotes activation of C3, combined action of MBL-associated serine proteases MASP-1 and MASP-2 required, involvement of the alternative pathway not detected
-
-
?
complement component C3 + H2O
complement component C3a + complement component C3b
interaction studies with decay-accelerating factor DAF mediating decay of the alternative pathway C3 convertase, C3bBb, but not of the inactive proenzyme C3bB
-
-
?
complement component C3 + H2O
complement component C3a + complement component C3b
potencies of the amplification loop of the alternative complement pathway summarized
-
-
?
complement component C3 + H2O
complement component C3a + complement component C3b
properdin-deficient patients susceptible to lethal meningococcal infection, studies on yet unknown mechanism of selective predisposition
-
-
?
complement component C3 + H2O
complement component C3a + complement component C3b
studies on fluid-phase formation of initial convertase by fluorescence resonance energy transfer (FRET)
-
-
?
complement component C3 + H2O
complement component C3a + complement component C3b
-
-
-
?
complement component C3 + H2O
complement component C3a + complement component C3b
-
-
-
-
?
complement component C3 + H2O
complement component C3a + complement component C3b
cleavage of complement component C3 through the mannan-binding lectin pathway in mouse sera determined
-
-
?
complement component C3 + H2O
complement component C3a + complement component C3b
complement activation in properdin-deficient mice analyzed
-
-
?
complement component C3 + H2O
complement component C3a + complement component C3b
-
-
-
-
?
complement component C3 zymogen + H2O
complement component C3b + complement component C3a
-
-
-
?
complement component C3 zymogen + H2O
complement component C3b + complement component C3a
activation
-
-
?
complement component C5 + H2O
complement component C5a + complement component C5b
-
-
-
?
complement component C5 + H2O
complement component C5a + complement component C5b
-
-
-
-
?
complement component C5 + H2O
complement component C5a + complement component C5b
-
-
-
?
complement component C5 + H2O
complement component C5a + complement component C5b
-
-
-
?
complement component C5 + H2O
complement component C5a + complement component C5b
-
-
-
-
?
complement component C5 + H2O
complement component C5a + complement component C5b
-
-
-
?
complement component C5 + H2O
complement component C5a + complement component C5b
-
-
-
-
?
complement component C5 + H2O
complement component C5a + complement component C5b
-
-
-
?
complement component C5 + H2O
complement component C5a + complement component C5b
-
methionine-modified enzyme has significantly lower C5-cleavage ability than that of unmodified enzyme
-
-
?
complement component C5 + H2O
complement component C5a + complement component C5b
-
-
-
?
complement component C5 + H2O
complement component C5a + complement component C5b
-
-
-
-
?
complement component C5 zymogen + H2O
complement component C5b + complement component C5a
-
-
-
?
complement component C5 zymogen + H2O
complement component C5b + complement component C5a
activation
-
-
?
additional information
?
-
-
fragment Bb is the catalytic subunit of the enzyme, isolated Bb is unable to cleave either C3 or C5
-
-
?
additional information
?
-
-
the enzyme is involved in the alternative pathway of human complement
-
-
?
additional information
?
-
-
the activation peptide, C5a, possesses potent spasmogenic and chemotactic activity
-
-
?
additional information
?
-
-
the enzyme has a very short half-life. Dissociation of the two noncovalently bound subunits proceeds with a half-life of 1-3 min at 37°C under physiological conditions, and this rate increases greatly if regulatory proteins are present. Numerous decay-accelerating proteins are present in plasma and on host cells that bind to the noncatalytic subunit C3b and increase the rate at which the catalytic subunit Bb is released into the medium. Bb loses its enzymatic activity and its ability to bind to C3b upon release. Although C3b is able to rebind Bb and reform the enzyme, the interaction with most decay-accelerating factors also leads to permanent proteolytic interaction of the cell-bound subunit C3b by a fluid-phase protease Factor I. These regulatory events limit cleavage of C3, reduce release of the anaphylatoxin C3a and control the formation of more efficient C5 convertase enzymes
-
?
additional information
?
-
early complement stimulation in trauma patients analyzed, correlation with injury severity, tissue hypoperfusion and worse clinical outcomes identified
-
-
?
additional information
?
-
C3b binds uniformly to substances on the surface of Escherichia coli K12, whereas it shows a bimodal distribution on the surface of Staphylococcus aureus P209. Autoactivation activity of C3
-
-
?
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6-amidino-2-naphthyl-4-guanidinobenzoate
-
Ab (2B7)
inhibits the deposition of C3b on Escherichia coli in hemolymph plasma, whereas it exhibits no inhibitory effect on the deposition of C3b on Staphylococcus aureus
-
Aurin tricarboxylic acid
blocks the alternative pathway at a downstream step from C3b attachment. It prevents formation of C3 convertase at the stage where Factor B, attached to the membrane-bound properdin-C3b-Factor B (PC3bB) complex, is cleaved by the protease action of Factor D to form the active C3 convertase enzyme PC3bBb. Activity is restored by the addition of excess Factor D to the serum. But membrane attack complex formation is still blocked by ATA at the stage of C9 addition to C5b678. It has no effect on the classical pathway activation. Binding of aurin tricarboxylic acid to the QPDTIDHDLLLLQLS site blocks the ability of aurin tricarboxylic acid to bind to Factor D protein
C3b-specific antibody fragment S77
-
inhibits the alternative pathway C5 convertase in human serum
-
C4BP
-
the inhibitor blocks both C3 and C5 conversion
-
complement factor H-related protein 1
-
0.005-0.16 mg/ml inhibits C5 convertase activity
-
complement receptor 1
CR1, mediates decay acceleration of the C3bBb complex
-
complement receptor of immunoglobulin family
-
the inhibitor blocks both C3 and C5 conversion
-
Cp40
-
the inhibitor blocks both C3 and C5 conversion
-
CRIg
phagocytic receptor, binds to the beta-chain of complement components C3b and C3c and inhibits the AP C3 and C5 convertases, structure-activity relationship of CRIg mutants indicated
-
decay accelerating factor
DAF, mediates decay acceleration of the C3bBb complex
-
decay-accelerating factor
DAF, CD55, major site of interaction with the larger cleavage subunit complement component factor B (Bb), interaction pathway dissected, second short consensus repeat (SCR) domain of DAF (SCR2) interacts only with fragment Bb, whereas SCR4 interacts with complement component C3b, SCR3 does not directly interact with either subunit
-
Efb-C
-
C-terminal region of extracellular fibrinogen binding protein. The inhibitor specifically blocks C5 conversion, while leaving C3 conversion unaffected
-
extracellular complement binding protein
-
the inhibitor specifically blocks C5 conversion, while leaving C3 conversion unaffected
-
factor H related-protein 5
-
inhibits C5 conversion in a concentration-dependent manner
-
hemocyanin-depleted plasma
preincubation of hemocyanin-depleted plasma with the anti-factor C Ab (2B7) dose-dependently inhibits the proteolytic conversion of C3 to C3b in the presence of LPS
-
hydroxylamine
inactivates the thioester bond on C3, dramatically decreases the deposition of C3b on microbes
Leu-Gly-Leu-Ala-Arg-sarcosine
-
inhibits C5 cleavage
OmCI
-
the inhibitor blocks C5 cleavage by interfering with convertase recognition far from C5a
-
Ornithodoros moubata complement inhibitory protein
-
the inhibitor specifically interfers with C5 conversion but not C3 conversion
-
Pra1
-
i. e. Candida albicans complement regulator acquiring surface protein 2 or pH-regulated Ag 1. In the direct surrounding of the pathogen, inhibitor binds to fluid-phase C3, blocks cleavage of C3 to C3a and C3b and inhibits complement activation via the alternative and classical pathways. In addition, the release of the anaphylatoxins C3a and C5a, as well as C3b/iC3b surface deposition, is reduced. By reducing C3b/iC3b levels at the yeast surface, Pra1 decreases complement-mediated adhesion, as well as uptake of Candida albicans by human macrophages
-
soluble complement receptor type 1
-
-
-
SSL7
-
the inhibitor blocks C5 cleavage by interfering with convertase recognition far from C5a
-
staphylococcal complement inhibitor
-
thioredoxin 1
Trx-1, causes significant inhibition of alternative convertases, mechanism, overview. Trx-1 is capable of inhibiting all classical and alternative convertases but its effect is more pronounced in inhibition of alternative ones
TT32
-
human complement receptor type 2 (CR2)/CR1 fusion protein
-
eculizumab
-
-
-
eculizumab
-
the inhibitor specifically interfers with C5 conversion but not C3 conversion
-
factor H
mediates decay acceleration of the C3bBb complex
-
factor H
a well known inhibitor of the alternative complement pathway
-
factor H
-
the inhibitor blocks both C3 and C5 conversion
-
staphylococcal complement inhibitor
-
from Staphylococcus aureus, binds and blocks active convertases in solution and induced dimerization of C3bBb
-
staphylococcal complement inhibitor
-
-
-
TT30
-
therapeutic fusion protein linking the human complement receptor type 2 C3 fragment-binding domain with the CAP inhibitory domain of human factor H. TT30 efficiently blocks ex vivo CAP-dependent accumulation of C3-fragment on activated surfaces, membrane attack complex formation and hemolysis of red blood cells, without interference of C3 activation or membrane attack complex formation
-
TT30
-
complement alternative pathway-selective inhibitor, fusion protein linking the first four short consensus repeats of human complement receptor type 2 with the first five short consensus repeats of human factor H
-
additional information
-
eculizumab does not block the activity of the APC C3 convertase
-
additional information
-
the anti-factor B autoantibody binds to factor B and to the alternative pathway C3 convertase and alters the kinetics of complement activation and regulation, the anti-factor B autoantibody does not influence the assembly of the C3 convertase
-
additional information
addition of guinea pig serum in 40 mM EDTA initiates lysis of existing convertase complexes and excludes the possibility of de novo convertase formation
-
additional information
regulatory proteins inactivate C3/C5 convertases on host surfaces to avoid collateral tissue damage
-
additional information
the anticoagulogen Ab (14E7) has no effect on the conversion of C3. Abs against coagulation factor G (monoclonal) and the proclotting enzyme (polyclonal) do not inhibit the deposition of C3b on Escherichia coli
-
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Pangburn, M.K.; Muller-Eberhard, H.J.
The C3 convertase of the alternative pathway of human complement. Enzymic properties of the bimolecular proteinase
Biochem. J.
235
723-730
1986
Homo sapiens
brenda
DiScipio, R.G.; Smith, C.A.; Muller-Eberhard, H.J.; Hugli, T.E.
The activation of human complement component C5 by a fluid phase C5 convertase
J. Biol. Chem.
258
10629-10636
1983
Homo sapiens
brenda
Gutierrez, J.C.; Gtze, O.; Caporale, L.H.
An improved fluorogenic substrate for the alternative complement pathway C3/5 converting enzyme CVFBb
Biochim. Biophys. Acta
744
276-280
1983
Homo sapiens
brenda
Vogel, C.W.; Muller-Eberhard, H.J.
The cobra venom factor-dependent C3 convertase of human complement. A kinetic and thermodynamic analysis of a protease acting on its natural high molecular weight substrate
J. Biol. Chem.
257
8292-8299
1982
Homo sapiens
brenda
Kerr, M.A.
Human factor B
Methods Enzymol.
80
102-112
1981
Homo sapiens
brenda
Schwaeble, W.; Luttig, B.; Sokolowski, T.; Estaller, C.; Weiss, E.H.; Meyer zum Bschenfelde, K.H.; Whaley, K.; Dippold, W.
Human complement factor B: functional properties of a recombinant zymogen of the alternative activation pathway convertase
Immunobiology
188
221-232
1993
Homo sapiens
brenda
Williams, S.C.; Sim, R.B.
Dye-ligand affinity purification of human complement factor B and beta 2 glycoprotein I
J. Immunol. Methods
157
25-30
1993
Homo sapiens
brenda
Hourcade, D.E.; Mitchell, L.M.; Oglesby, T.J.
A conserved element in the serine protease domain of complement factor B
J. Biol. Chem.
273
25996-26000
1998
Homo sapiens
brenda
Sumiyoshi, K.; Andoh, A.; Fujiyama, Y.; Sakumoto, H.; Bamba, T.
Characterization of complement C3, C4, and factor B molecules in human bile
J. Gastroenterol.
32
230-235
1997
Homo sapiens
brenda
Fu, Q.; McPhie, P.; Gowda, D.C.
Methionine modification impairs the C5-cleavage function of cobra venom factor-dependent C3/C5 convertase
Biochem. Mol. Biol. Int.
45
133-144
1998
Homo sapiens
brenda
Berkovich, SA.; O'Keefe, M.C.; Hensley, P.; Caporale, L.
Effect of N-methylation on the modulation by synthetic peptides of the activity of the complement-factor-B-derived serine proteinase CVFBb
Biochem. J.
270
531-537
1990
Homo sapiens
brenda
Jelezarova, E.; Vogt, A.; Lutz, H.U.
Interaction of C3b(2)-IgG complexes with complement proteins properdin, factor B and factor H: implications for amplification
Biochem. J.
349
217-223
2000
Homo sapiens
brenda
Pangburn, M.K.; Rawal, N.
Structure and function of complement C5 convertase enzymes
Biochem. Soc. Trans.
30
1006-1010
2002
Homo sapiens
brenda
Hourcade, D.E.; Mitchell, L.; Kuttner-Kondo, L.A.; Atkinson, J.P.; Medof, M.E.
Decay-accelerating factor (DAF), complement receptor 1 (CR1), and factor H dissociate the complement AP C3 convertase (C3bBb) via sites on the type A domain of Bb
J. Biol. Chem.
277
1107-1112
2002
Homo sapiens
brenda
Rawal, N.; Pangburn, M.K.
Functional role of the noncatalytic subunit of complement C5 convertase
J. Immunol.
164
1379-1385
2000
Homo sapiens
brenda
Koelln, J.; Bredehorst, R.; Spillner, E.
Engineering of human complement component C3 for catalytic inhibition of complement
Immunol. Lett.
98
49-56
2005
Homo sapiens
brenda
Hourcade, D.E.
The role of properdin in the assembly of the alternative pathway C3 convertases of complement
J. Biol. Chem.
281
2128-2132
2006
Homo sapiens
brenda
Selander, B.; Martensson, U.; Weintraub, A.; Holmstroem, E.; Matsushita, M.; Thiel, S.; Jensenius, J.C.; Truedsson, L.; Sjoeholm, A.G.
Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2
J. Clin. Invest.
116
1425-1434
2006
Homo sapiens
brenda
Koelln, J.; Spillner, E.; Andrae, J.; Klensang, K.; Bredehorst, R.
Complement inactivation by recombinant human C3 derivatives
J. Immunol.
173
5540-5545
2004
Homo sapiens
brenda
Ponnuraj, K.; Xu, Y.; Macon, K.; Moore, D.; Volanakis, J.E.; Narayana, S.V.
Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase
Mol. Cell
14
17-28
2004
Homo sapiens (P00751)
brenda
Jelezarova, E.; Lutz, H.U.
IgG naturally occurring antibodies stabilize and promote the generation of the alternative complement pathway C3 convertase
Mol. Immunol.
42
1393-1403
2005
Homo sapiens
brenda
Huber-Lang, M.; Sarma, J.V.; Zetoune, F.S.; Rittirsch, D.; Neff, T.A.; McGuire, S.R.; Lambris, J.D.; Warner, R.L.; Flierl, M.A.; Hoesel, L.M.; Gebhard, F.; Younger, J.G.; Drouin, S.M.; Wetsel, R.A.; Ward, P.A.
Generation of C5a in the absence of C3: a new complement activation pathway
Nat. Med.
12
682-687
2006
Mus musculus
brenda
Moller-Kristensen, M.; Thiel, S.; Sjoeholm, A.; Matsushita, M.; Jensenius, J.C.
Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway
Int. Immunol.
19
141-149
2007
Homo sapiens (P00751), Mus musculus (P04186)
brenda
Kimura, Y.; Miwa, T.; Zhou, L.; Song, W.C.
Activator-specific requirement of properdin in the initiation and amplification of the alternative pathway complement
Blood
111
732-740
2008
Homo sapiens (P00751), Homo sapiens, Mus musculus (P04186), Mus musculus
brenda
Harris, C.L.; Pettigrew, D.M.; Lea, S.M.; Morgan, B.P.
Decay-accelerating factor must bind both components of the complement alternative pathway C3 convertase to mediate efficient decay
J. Immunol.
178
352-359
2007
Homo sapiens (P00751)
brenda
Lutz, H.U.; Fumia, S.; Schurtenberger, C.; Alaia, V.
Opinion paper: Stimulation of complement amplification or activation of the alternative pathway of complement?
Mol. Immunol.
44
3862-3865
2007
Homo sapiens (P00751)
brenda
Bexborn, F.; Andersson, P.O.; Chen, H.; Nilsson, B.; Ekdahl, K.N.
The tick-over theory revisited: Formation and regulation of the soluble alternative complement C3 convertase (C3(H(2)O)Bb)
Mol. Immunol.
45
2370-2379
2008
Homo sapiens (P00751)
brenda
Wiesmann, C.; Katschke, K.J.; Yin, J.; Helmy, K.Y.; Steffek, M.; Fairbrother, W.J.; McCallum, S.A.; Embuscado, L.; DeForge, L.; Hass, P.E.; van Lookeren Campagne, M.
Structure of C3b in complex with CRIg gives insights into regulation of complement activation
Nature
444
217-220
2006
Homo sapiens (P00751)
brenda
Ganter, M.T.; Brohi, K.; Cohen, M.J.; Shaffer, L.A.; Walsh, M.C.; Stahl, G.L.; Pittet, J.F.
Role of the alternative pathway in the early complement activation following major trauma
Shock
28
29-34
2007
Homo sapiens (P00751)
brenda
Rawal, N.; Rajagopalan, R.; Salvi, V.P.
Activation of complement component C5: comparison of C5 convertases of the lectin pathway and the classical pathway of complement
J. Biol. Chem.
283
7853-7863
2008
Homo sapiens
brenda
Ariki, S.; Takahara, S.; Shibata, T.; Fukuoka, T.; Ozaki, A.; Endo, Y.; Fujita, T.; Koshiba, T.; Kawabata, S.
Factor C acts as a lipopolysaccharide-responsive C3 convertase in horseshoe crab complement activation
J. Immunol.
181
7994-8001
2008
Tachypleus tridentatus (B6ZH52)
brenda
Torreira, E.; Tortajada, A.; Montes, T.; Rodriguez de Cordoba, S.; Llorca, O.
3D structure of the C3bB complex provides insights into the activation and regulation of the complement alternative pathway convertase
Proc. Natl. Acad. Sci. USA
106
882-887
2009
Homo sapiens (P00751)
brenda
Heinen, S.; Hartmann, A.; Lauer, N.; Wiehl, U.; Dahse, H.M.; Schirmer, S.; Gropp, K.; Enghardt, T.; Wallich, R.; Haelbich, S.; Mihlan, M.; Schloetzer-Schrehardt, U.; Zipfel, P.F.; Skerka, C.
Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation
Blood
114
2439-2447
2009
Homo sapiens
brenda
Roumenina, L.T.; Jablonski, M.; Hue, C.; Blouin, J.; Dimitrov, J.D.; Dragon-Durey, M.A.; Cayla, M.; Fridman, W.H.; Macher, M.A.; Ribes, D.; Moulonguet, L.; Rostaing, L.; Satchell, S.C.; Mathieson, P.W.; Sautes-Fridman, C.; Loirat, C.; Regnier, C.H.; Halbwachs-Mecarelli, L.; Fremeaux-Bacchi, V.
Hyperfunctional C3 convertase leads to complement deposition on endothelial cells and contributes to atypical hemolytic uremic syndrome
Blood
114
2837-2845
2009
Rattus norvegicus
brenda
Lindorfer, M.A.; Pawluczkowycz, A.W.; Peek, E.M.; Hickman, K.; Taylor, R.P.; Parker, C.J.
A novel approach to preventing the hemolysis of paroxysmal nocturnal hemoglobinuria: both complement-mediated cytolysis and C3 deposition are blocked by a monoclonal antibody specific for the alternative pathway of complement
Blood
115
2283-2291
2010
Homo sapiens
brenda
Katschke, K.J.; Stawicki, S.; Yin, J.; Steffek, M.; Xi, H.; Sturgeon, L.; Hass, P.E.; Loyet, K.M.; Deforge, L.; Wu, Y.; van Lookeren Campagne, M.; Wiesmann, C.
Structural and functional analysis of a C3b-specific antibody that selectively inhibits the alternative pathway of complement
J. Biol. Chem.
284
10473-10479
2009
Homo sapiens
brenda
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Homo sapiens
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Homo sapiens
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Homo sapiens
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Wu, J.; Wu, Y.Q.; Ricklin, D.; Janssen, B.J.; Lambris, J.D.; Gros, P.
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Homo sapiens
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Laursen, N.S.; Gordon, N.; Hermans, S.; Lorenz, N.; Jackson, N.; Wines, B.; Spillner, E.; Christensen, J.B.; Jensen, M.; Fredslund, F.; Bjerre, M.; Sottrup-Jensen, L.; Fraser, J.D.; Andersen, G.R.
Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus
Proc. Natl. Acad. Sci. USA
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Homo sapiens
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Camous, L.; Roumenina, L.; Bigot, S.; Brachemi, S.; Fremeaux-Bacchi, V.; Lesavre, P.; Halbwachs-Mecarelli, L.
Complement alternative pathway acts as a positive feedback amplification of neutrophil activation
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Homo sapiens
brenda
Fridkis-Hareli, M.; Storek, M.; Mazsaroff, I.; Risitano, A.M.; Lundberg, A.S.; Horvath, C.J.; Holers, V.M.
Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases
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Homo sapiens
brenda
Li, Q.; Li, Y.X.; Stahl, G.L.; Thurman, J.M.; He, Y.; Tong, H.H.
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Mus musculus
brenda
Hourcade, D.E.; Mitchell, L.M.
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Homo sapiens
brenda
Martinez-Barricarte, R.; Heurich, M.; Valdes-Canedo, F.; Vazquez-Martul, E.; Torreira, E.; Montes, T.; Tortajada, A.; Pinto, S.; Lopez-Trascasa, M.; Morgan, B.P.; Llorca, O.; Harris, C.L.; Rodriguez de Cordoba, S.
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Homo sapiens
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Luo, S.; Hartmann, A.; Dahse, H.; Skerka, C.; Zipfel, P.
Secreted pH-regulated antigen 1 of Candida albicans blocks activation and conversion of complement C3
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Homo sapiens
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Forneris, F.; Ricklin, D.; Wu, J.; Tzekou, A.; Wallace, R.; Lambris, J.; Gros, P.
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Homo sapiens (P01024)
brenda
Hebecker, M.; Jozsi, M.
Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein
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Homo sapiens (P00751), Homo sapiens
brenda
Lee, M.; Guo, J.P.; McGeer, E.G.; McGeer, P.L.
Aurin tricarboxylic acid self-protects by inhibiting aberrant complement activation at the C3 convertase and C9 binding stages
Neurobiol. Aging
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Homo sapiens (P00751)
brenda
Okroj, M.; Holmquist, E.; King, B.C.; Blom, A.M.
Functional analyses of complement convertases using C3 and C5-depleted sera
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Homo sapiens (P00751)
brenda
Alcorlo, M.; Tortajada, A.; Rodriguez de Cordoba, S.; Llorca, O.
Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdin
Proc. Natl. Acad. Sci. USA
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Homo sapiens (P00751)
brenda
Ruggenenti, P.; Daina, E.; Gennarini, A.; Carrara, C.; Gamba, S.; Noris, M.; Rubis, N.; Peraro, F.; Gaspari, F.; Pasini, A.; Rigotti, A.; Lerchner, R.M.; Santoro, D.; Pisani, A.; Pasi, A.; Remuzzi, G.; Remuzzi, G.
C5 convertase blockade in membranoproliferative glomerulonephritis a single-arm clinical trial
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2019
Homo sapiens
brenda
Berends, E.T.; Gorham, R.D.; Ruyken, M.; Soppe, J.A.; Orhan, H.; Aerts, P.C.; de Haas, C.J.; Gros, P.; Rooijakkers, S.H.
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Homo sapiens
brenda
Heesterbeek, D.; Bardoel, B.; Parsons, E.; Bennett, I.; Ruyken, M.; Doorduijn, D.; Gorham, R.J.; Berends, E.; Pyne, A.; Hoogenboom, B.; Rooijakkers, S.
Bacterial killing by complement requires membrane attack complex formation via surface-bound C5 convertases
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Homo sapiens
brenda
Zwarthoff, S.A.; Berends, E.T.M.; Mol, S.; Ruyken, M.; Aerts, P.C.; Jozsi, M.; de Haas, C.J.C.; Rooijakkers, S.H.M.; Gorham, R.D.
Functional characterization of alternative and classical pathway C3/C5 convertase activity and inhibition using purified models
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Homo sapiens
brenda
Fridkis-Hareli, M.; Storek, M.; Or, E.; Altman, R.; Katti, S.; Sun, F.; Peng, T.; Hunter, J.; Johnson, K.; Wang, Y.; Lundberg, A.S.; Mehta, G.; Banda, N.K.; Michael Holers, V.
The human complement receptor type 2 (CR2)/CR1 fusion protein TT32, a novel targeted inhibitor of the classical and alternative pathway C3 convertases, prevents arthritis in active immunization and passive transfer mouse models
Mol. Immunol.
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2019
Homo sapiens
brenda
Di Fede, M.; Biagini, M.; Cartocci, E.; Parillo, C.; Greco, A.; Martinelli, M.; Marchi, S.; Pezzicoli, A.; Delany, I.; Rossi Paccani, S.
Neisseria heparin binding antigen is targeted by the human alternative pathway C3-convertase
PLoS ONE
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2018
Homo sapiens
brenda