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Information on EC 3.4.21.34 - plasma kallikrein and Organism(s) Mus musculus

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.34 plasma kallikrein
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This record set is specific for:
Mus musculus
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
selective cleavage of some Arg-/- and Lys-/- bonds, including Lys-/-Arg and Arg-/-Ser in (human) kininogen to release bradykinin
Synonyms
kallikrein, prekallikrein, plasma kallikrein, urinary kallikrein, kininogenase, plasma prekallikrein, plasma pk, pancreatic kallikrein, klk13, klkb1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
bradykininogenase
-
-
-
-
callicrein
-
-
-
-
depot-Padutin
-
-
-
-
dilminal D
-
-
-
-
Fletcher factor
-
-
-
-
glumorin
-
-
-
-
kallidinogenase
-
-
-
-
kallikrein
-
-
-
-
kallikrein I
-
-
-
-
kallikrein II
-
-
-
-
kininogenase
-
-
-
-
kininogenin
-
-
-
-
KLKb1
-
-
onokrein P
-
-
-
-
padreatin
-
-
-
-
padutin
-
-
-
-
pancreatic kallikrein
-
-
-
-
plasma PK
-
-
Plasma prekallikrein
-
-
-
-
plasma prokallikrein
-
zymogen
prekallikrein
-
precursor
serum kallikrein
-
-
-
-
urinary kallikrein
-
-
-
-
urokallikrein
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
410538-33-9
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-Phe-Phe-Arg-4-methylcoumarin 7-amide
D-Phe-Phe-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
factor X + H2O
factor XIIa + ?
show the reaction diagram
-
-
-
-
?
factor XII + H2O
?
show the reaction diagram
activation of the factor XII, bound to negatively charged surfaces
-
?, ir
factor XII + H2O
activated factor XII
show the reaction diagram
-
-
-
-
?
factor XII + H2O
activated factor XII + ?
show the reaction diagram
-
-
-
-
?
high molecular weight kininogen + H2O
bradykinin + fragments of kininogen
show the reaction diagram
-
-
-
-
?
high-molecular-weight kininogen + H2O
bradykinin + fragments of kininogen
show the reaction diagram
-
-
-
-
?
kininogen + H2O
bradykinin + fragments of kininogen
show the reaction diagram
plasminogen + H2O
plasmin + ?
show the reaction diagram
-
-
-
-
?
Prorenin + H2O
Renin + ?
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
factor X + H2O
factor XIIa + ?
show the reaction diagram
-
-
-
-
?
factor XII + H2O
?
show the reaction diagram
activation of the factor XII, bound to negatively charged surfaces
-
ir
factor XII + H2O
activated factor XII
show the reaction diagram
-
-
-
-
?
factor XII + H2O
activated factor XII + ?
show the reaction diagram
-
-
-
-
?
high molecular weight kininogen + H2O
bradykinin + fragments of kininogen
show the reaction diagram
-
-
-
-
?
high-molecular-weight kininogen + H2O
bradykinin + fragments of kininogen
show the reaction diagram
-
-
-
-
?
kininogen + H2O
bradykinin + fragments of kininogen
show the reaction diagram
plasminogen + H2O
plasmin + ?
show the reaction diagram
-
-
-
-
?
Prorenin + H2O
Renin + ?
show the reaction diagram
additional information
?
-
-
active plasma kallikrein localizes to mast cells and regulates epithelial cell apoptosis, adipocyte differentiation and stromal remodeling during mammary gland involution
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
alpha 2 macroglobulin
-
-
-
antipain
-
-
C1-inhibitor
-
-
-
diisopropylfluorophosphate
-
-
DX-88
-
DX-88 has a strong neuroprotective effect in the early phases of brain ischemia preventing reperfusion injury and indicates that inhibition of plasma kallikrein may be useful tool in the strategy aimed at reducing the detrimental effects linked to reperfusion
-
ecotin-plasma kallikrein
-
highly specific inhibitor of active plasma kallikrein
-
human IgG1 monoclonal antibody DX-2930
-
potently and specifically inhibits plasma kallikrein
-
leupeptin
-
-
mupain-1-16
-
Protein C inhibitor
-
-
-
Soybean trypsin inhibitor
-
-
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
activated factor XII
-
-
-
coagulation factor XIIa
-
-
-
factor XIIa
-
additional information
binding to negatively charged surfaces activates the enzyme
-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00000017
human IgG1 monoclonal antibody DX-2930
-
at pH 7.5 and 30°C
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
the enzyme is expressed in liver
Manually annotated by BRENDA team
-
mouse plasma kallikrein is differentially expressed in the developing mammary gland
Manually annotated by BRENDA team
-
active plasma kallikrein is localized to connective tissue-type mast cells in the mammary gland
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
plasma
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
KLKB1_MOUSE
638
1
71383
Swiss-Prot
Secretory Pathway (Reliability: 3)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
-
1 * 86000-88000, SDS-PAGE
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
apoenzyme and in complex with mupain-1-16, sitting drop vapor diffusion method, using 25% (w/v) poly(ethylene glycol) 3350, 0.1 M Tris-HCl pH8.5, 0.1 M NaCl
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
SP Sepharose column chromatography and Superdex 75 gel filtration
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Pichia pastoris strain, X-33
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Seidah, N.G.; Sawyer, N.; Hamelin, J.; Mion, P.; Beaubien, G.; Brachpapa, L.; Rochemont, J.; Mbikay, M.; Chretien, M.
Mouse plasma kallikrein: cDNA structure, enzyme characterization, and comparison of protein and mRNA levels among species
DNA Cell Biol.
9
737-748
1990
Mus musculus
Manually annotated by BRENDA team
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (P03952), Mus musculus (P26262), Rattus norvegicus (P14272)
Manually annotated by BRENDA team
Storini, C.; Bergamaschini, L.; Gesuete, R.; Rossi, E.; Maiocchi, D.; De Simoni, M.G.
Selective inhibition of plasma kallikrein protects brain from reperfusion injury
J. Pharmacol. Exp. Ther.
318
849-854
2006
Mus musculus
Manually annotated by BRENDA team
Lilla, J.N.; Joshi, R.V.; Craik, C.S.; Werb, Z.
Active plasma kallikrein localizes to mast cells and regulates epithelial cell apoptosis, adipocyte differentiation and stromal remodeling during mammary gland involution
J. Biol. Chem.
284
13792-13803
2009
Mus musculus
Manually annotated by BRENDA team
Renne, T.
The vascular side of plasma kallikrein
Blood
125
589-590
2015
Mus musculus
Manually annotated by BRENDA team
Kenniston, J.; Faucette, R.; Martik, D.; Comeau, S.; Lindberg, A.; Kopacz, K.; Conley, G.; Chen, J.; Viswanathan, M.; Kastrapeli, N.; Cosic, J.; Mason, S.; DiLeo, M.; Abendroth, J.; Kuzmic, P.; Ladner, R.; Edwards, T.; TenHoor, C.; Adelman, B.; Nixon, A.;
Inhibition of plasma kallikrein by a highly specific active site blocking antibody
J. Biol. Chem.
289
23596-23608
2014
Macaca fascicularis, Mus musculus, Rattus norvegicus, Homo sapiens (P03952), Homo sapiens
Manually annotated by BRENDA team
Renne, T.; Gruber, A.
Plasma kallikrein: Novel functions for an old protease
Thromb. Haemost.
107
1012-1013
2012
Mus musculus
Manually annotated by BRENDA team
Feener, E.P.; Zhou, Q.; Fickweiler, W.
Role of plasma kallikrein in diabetes and metabolism
Thromb. Haemost.
110
434-441
2013
Mus musculus
Manually annotated by BRENDA team
Xu, M.; Chen, Y.; Xu, P.; Andreasen, P.A.; Jiang, L.; Li, J.; Huang, M.
Crystal structure of plasma kallikrein reveals the unusual flexibility of the S1 pocket triggered by Glu217
FEBS Lett.
592
2658-2667
2018
Mus musculus (P26262), Mus musculus
Manually annotated by BRENDA team
Schmaier, A.H.
Plasma prekallikrein its role in hereditary angioedema and health and disease
Front. Med.
5
3-3
2018
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Goebel, K.; Asaridou, C.M.; Merker, M.; Eichler, S.; Herrmann, A.M.; Geuss, E.; Ruck, T.; Schuengel, L.; Groeneweg, L.; Narayanan, V.; Schneider-Hohendorf, T.; Gross, C.C.; Wiendl, H.; Kehrel, B.E.; Kleinschnitz, C.; Meuth, S.G.
Plasma kallikrein modulates immune cell trafficking during neuroinflammation via PAR2 and bradykinin release
Proc. Natl. Acad. Sci. USA
116
271-276
2019
Homo sapiens, Mus musculus
Manually annotated by BRENDA team