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Information on EC 3.4.21.34 - plasma kallikrein and Organism(s) Bos taurus

for references in articles please use BRENDA:EC3.4.21.34

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3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.34 plasma kallikrein

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The taxonomic range for the selected organisms is: Bos taurus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

Reaction Schemes

selective cleavage of some Arg-/- and Lys-/- bonds, including Lys-/-Arg and Arg-/-Ser in (human) kininogen to release bradykinin

Synonyms

kallikrein, prekallikrein, plasma kallikrein, urinary kallikrein, kininogenase, plasma prekallikrein, plasma pk, pancreatic kallikrein, klk13, klkb1, show all synonyms

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bradykininogenase

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callicrein

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depot-Padutin

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dilminal D

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Fletcher factor

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glumorin

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kallidinogenase

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kallikrein

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kallikrein I

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kallikrein II

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kininogenase

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kininogenin

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onokrein P

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padreatin

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padutin

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pancreatic kallikrein

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Plasma prekallikrein

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serum kallikrein

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urinary kallikrein

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urokallikrein

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Go to CAS Registry Number Search

410538-33-9

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kininogen + H2O

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show the reaction diagram

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cleaves Lys-Arg and Arg-Ser bonds in kininogen to produce bradykinin, participates in early phase of intrinsic blood coagulation

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Nalpha-Benzoyl-L-Arg ethyl ester + H2O

Nalpha-Benzoyl-L-Arg + ethanol

show the reaction diagram

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Nalpha-toluenesulfonyl-L-arginine methyl ester + H2O

Nalpha-toluenesulfonyl-L-arginine + methanol

show the reaction diagram

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kininogen + H2O

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show the reaction diagram

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cleaves Lys-Arg and Arg-Ser bonds in kininogen to produce bradykinin, participates in early phase of intrinsic blood coagulation

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Go to KM Value Search

0.0962

Nalpha-benzoyl-L-arginine ethyl ester

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0.00156

Nalpha-toluenesulfonyl-L-arginine methyl ester

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additional information

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8.8

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Manually annotated by BRENDA team

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Manually annotated by BRENDA team

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Go to Localization Search

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Manually annotated by BRENDA team

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Go to AA Sequence and Transmembrane Helices SearchGo to Localization Prediction

KLKB1_BOVIN

636

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70994

Swiss-Prot

Secretory Pathway (Reliability: 2)

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Go to Molecular Weight Search

82000

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sedimentation equilibrium

95000

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gel filtration

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Go to Posttranslational Modification Search

glycoprotein

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Go to Purification (commentary) Search

prekallikrein

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Colman, R.W.; Bagdasarian, A.

Human kallikrein and prekallikrein

Methods Enzymol.

45

303-322

1976

Bos taurus, Homo sapiens

Manually annotated by BRENDA team

Heimark, R.L.; Davie, E.W.

Bovine and human plasma prekallikrein

Methods Enzymol.

80

157-173

1981

Bos taurus, Homo sapiens

Manually annotated by BRENDA team

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Release 2023.1 (January 2023)