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35 kDa pro-interleukin 1beta + H2O
17.5 kDa interleukin 1beta + 20 kDa interleukin 1beta
-
cleavage of Leu113-Leu114 bond
-
-
?
Abz-GFSPFRSSRIQ-EDDnp + H2O
Abz-GFSPFR + SSRIQ-EDDnp
-
-
-
-
?
Abz-KLKSSKQ-EDDnp + H2O
Abz-KLK + SSKQ-EDDnp
-
-
-
-
?
Abz-KLRKSKQ-EDDnp + H2O
Abz-KLR + KSKQ-EDDnp
-
-
-
-
?
Abz-KLRRSKQ-EDDnp + H2O
Abz-KLR + RSKQ-EDDnp
-
-
-
-
?
Abz-KLRSSKQ-EDDnp + H2O
Abz-KLR + SSKQ-EDDnp
-
best substrate
-
-
?
Abz-MISLMKRPPGFSPFRSSRI-NH2 + H2O
Abz-MISLMKRPPGFSPFR + SSRI-NH2
-
rapid cleavage
-
-
?
Abz-MISLMKRPQ-EDDnp + H2O
Abz-MISLMK + RPQ-EDDnp
-
-
-
-
?
ABZ-Val-Arg-Phe-Arg-5-amino-2-nitrobenzoic acid + H2O
ABZ-Val-Arg-Phe-Arg + 5-amino-2-nitrobenzoic acid
kinetically preferred substrate
-
-
?
ABZ-VRFRSTG-Tyr(3-NO2)-NH2 + H2O
ABZ-VRFR + STG-Tyr(3-NO2)-NH2
-
-
-
?
ABZ-VRFRSTQ-Tyr(3-NO2)-NH2 + H2O
ABZ-VRFR + STQ-Tyr(3-NO2)-NH2
-
-
-
?
ABZ-VRFRSTS-Tyr(3-NO2)-NH2 + H2O
ABZ-VRFR + STS-Tyr(3-NO2)-NH2
-
-
-
?
benzyloxycarbonyl-Arg-Val-Arg-Arg-4-methyl-coumaryl-7-amide + H2O
benzyloxycarbonyl-Arg-Val-Arg-Arg + 7-amino-4-methylcoumarin
-
low activity
-
-
?
benzyloxycarbonyl-Gln-Arg-Arg-4-methyl-coumaryl-7-amide + H2O
benzyloxycarbonyl-Gln-Arg-Arg + 7-amino-4-methylcoumarin
-
best substrate
-
-
?
benzyloxycarbonyl-Glu-Lys-Lys-4-methyl-coumaryl-7-amide + H2O
benzyloxycarbonyl-Glu-Lys-Lys + 7-amino-4-methylcoumarin
-
low activity
-
-
?
benzyloxycarbonyl-Leu-Lys-Arg-4-methyl-coumaryl-7-amide + H2O
benzyloxycarbonyl-Leu-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Boc-Phe-Ser-Arg-7-amido-4-methylcoumarin + H2O
?
-
-
-
-
?
FSR-amido-4-methylcoumarin + H2O
FSR + 7-amino-4-methylcoumarin
-
fluorogenic trypsin-like peptide substrate
-
-
?
histatin 3 + H2O
DSHAKRHHGYKRKFHEKHHSHRGYR + SNYLYDN
-
i.e. DSHAKRHHGYKRKFHEKHHSHRGYRSNYLYDN, efficient substrate
-
-
?
low molecular weight human kininogen + H2O
?
-
-
-
-
?
mouse prorenin Ren2 + H2O
renin + ?
-
specific cleavage of Lys-Arg bond of mouse prorenin Ren2
-
-
?
myelin basic protein + H2O
?
-
at least two cleavage sites are identified at YGGR-ASDYK and PRHR-DTGI
-
-
?
polypeptide + H2O
peptides
pyroglutamyl-Arg-Tyr-Lys-Arg-4-methyl-coumaryl-7-amide + H2O
pyroglutamyl-Arg-Tyr-Lys-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
VPR-amido-4-methylcoumarin + H2O
VPR + 7-amino-4-methylcoumarin
-
fluorogenic trypsin-like peptide substrate
-
-
?
additional information
?
-
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
-
-
?
polypeptide + H2O
peptides
-
cleavage site at paired basic amino acid residues
-
?
polypeptide + H2O
peptides
-
cleavage site at paired basic amino acid residues
-
?
Prorenin + H2O
Renin + ?
-
cleavage site at paired basic amino acid residues
-
?
Prorenin + H2O
Renin + ?
-
cleavage site at paired basic amino acid residues
-
?
Prorenin + H2O
Renin + ?
-
cleavage site at paired basic amino acid residues
-
?
Prorenin + H2O
Renin + ?
-
cleavage site at paired basic amino acid residues
-
?
Prorenin + H2O
Renin + ?
-
no cleavage of the peptide bond between Arg and Pro
-
?
Prorenin + H2O
Renin + ?
-
specifically cleaves the peptide bond on the COOH-side of the Arg residue at the Lys-Arg pair of mouse Ren 2 prorenin, but does not cleave mouse Ren 1 and human prorenins
-
?
Prorenin + H2O
Renin + ?
-
mouse prorenin from submandibular gland
-
?
Prorenin + H2O
Renin + ?
-
recombinant murine prorenin 2
-
?
Prorenin + H2O
Renin + ?
-
murine or human origin substrate from Xenopus oocytes expression system
-
?
Prorenin + H2O
Renin + ?
-
inactive precursor
product is an active enzyme
?
Prorenin + H2O
Renin + ?
-
inactive precursor
product is an active enzyme
?
Prorenin + H2O
Renin + ?
-
inactive precursor
product is an active enzyme
?
additional information
?
-
-
enzyme is involved in tissue remodeling and/or tumor invasion and metastasis
-
-
?
additional information
?
-
-
KLK13 does not hydrolyze Abz-KLRESKQ-EDDnp, Abz-KLRSEKQ-EDDnp, and AbzeELRSSKQ-EDDnp
-
-
?
additional information
?
-
-
the S2' subsite of KLK13 does not have restricted specificity but does present preference for the basic amino acid R and does not accepted negative charge
-
-
?
additional information
?
-
-
glycosylation near the processing site might prevent hydrolysis
-
-
?
additional information
?
-
-
substrate specificty
-
-
?
additional information
?
-
-
no substrate: mouse prorenin Ren1, human prorenin
-
-
?
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Adenocarcinoma of Lung
Epigenetic activation of human kallikrein 13 enhances malignancy of lung adenocarcinoma by promoting N-cadherin expression and laminin degradation.
Breast Neoplasms
Development of Chemical Tools to Monitor Human Kallikrein 13 (KLK13) Activity.
Carcinogenesis
Mucin 16 and kallikrein 13 as potential prognostic factors in colon cancer: Results of an oncological 92-multiplex immunoassay.
Carcinoma
Correction to: Expression of kallikrein-related peptidase 13 is associated with poor prognosis in esophageal squamous cell carcinoma.
Carcinoma
Decreased expression of kallikrein-related peptidase 13: Possible contribution to metastasis of human oral cancer.
Carcinoma
Expression of kallikrein-related peptidase 13 is associated with poor prognosis in esophageal squamous cell carcinoma.
Carcinoma
Kallikrein-related peptidase 13 (KLK13) gene expressional status contributes significantly in the prognosis of primary gastric carcinomas.
Carcinoma, Non-Small-Cell Lung
Kallikrein-related peptidase 13: an independent indicator of favorable prognosis for patients with nonsmall cell lung cancer.
Carcinoma, Ovarian Epithelial
KLK6 and KLK13 predict tumor recurrence in epithelial ovarian carcinoma.
Colonic Neoplasms
Mucin 16 and kallikrein 13 as potential prognostic factors in colon cancer: Results of an oncological 92-multiplex immunoassay.
Diabetic Cardiomyopathies
Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium.
Dry Eye Syndromes
Autoantibodies Contribute to the Immunopathogenesis of Experimental Dry Eye Disease.
Esophageal Squamous Cell Carcinoma
Correction to: Expression of kallikrein-related peptidase 13 is associated with poor prognosis in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Expression of kallikrein-related peptidase 13 is associated with poor prognosis in esophageal squamous cell carcinoma.
Hyperglycemia
Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium.
Hypertension
Kallikrein-like prorenin-converting enzymes in inbred hypertensive mice.
Hypertension
Renin activity and angiotensin I concentration in genetically selective inbred line of hypertensive mice.
Infections
Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1.
Lung Neoplasms
Kallikrein-related peptidase 13: an independent indicator of favorable prognosis for patients with nonsmall cell lung cancer.
Mouth Neoplasms
Decreased expression of kallikrein-related peptidase 13: Possible contribution to metastasis of human oral cancer.
Neoplasm Metastasis
Decreased expression of kallikrein-related peptidase 13: Possible contribution to metastasis of human oral cancer.
Neoplasms
Epigenetic activation of human kallikrein 13 enhances malignancy of lung adenocarcinoma by promoting N-cadherin expression and laminin degradation.
Neoplasms
Expression of kallikrein-related peptidase 13 is associated with poor prognosis in esophageal squamous cell carcinoma.
Neoplasms
Human kallikrein 13 expression in salivary gland tumors.
Neoplasms
KLK6 and KLK13 predict tumor recurrence in epithelial ovarian carcinoma.
Ovarian Neoplasms
Human kallikrein 13 protein in ovarian cancer cytosols: a new favorable prognostic marker.
Squamous Cell Carcinoma of Head and Neck
Decreased expression of kallikrein-related peptidase 13: Possible contribution to metastasis of human oral cancer.
Stomach Neoplasms
The kallikrein-related peptidase 13 (KLK13) gene is substantially up-regulated after exposure of gastric cancer cells to antineoplastic agents.
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Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Mus musculus (P36368)
brenda
Kikkawa, Y.; Yamanaka, N.; Tada, J.; Kanamori, N.; Tsumura, K.; Hosoi, K.
Prorenin processing and restricted endoproteolysis by mouse tissue kallikrein family enzymes (mK1, mK9, mK13, and mK22)
Biochim. Biophys. Acta
1382
55-64
1998
Mus musculus
brenda
Nakayama, K.; Kim, W.S.; Hatsuzawa, K.; Hashiba, K.; Murakami, K.
Tissue distribution and characterization of prorenin-converting enzyme in mouse
Biochem. Biophys. Res. Commun.
158
369-376
1989
Mus musculus
brenda
Nakayama, K.; Kim, W.S.; Nakagawa, T.; Nagahama, M; Murakami, K.
Substrate specificity of prorenin converting enzyme of mouse submandibular gland. Analysis using site-directed mutagenesis
J. Biol. Chem.
265
21027-21031
1990
Mus musculus
brenda
Timm, D.E.
The crystal structure of the mouse glandular kallikrein-13 (prorenin converting enzyme)
Protein Sci.
6
1418-1425
1997
Mus musculus
brenda
Kapadia, C.; Chang, A.; Sotiropoulou, G.; Yousef, G.M.; Grass, L.; Soosaipillai, A.; Xing, X.; Howarth, D.H.; Diamandis, E.P.
Human kallikrein 13: production and purification of recombinant protein and monoclonal and polyclonal antibodies, and development of a sensitive and specific immunofluorometric assay
Clin. Chem.
49
77-86
2003
Homo sapiens
brenda
Yousef G.M.; Chang A.; Diamandis E.P.
Identification and characterization of KLK-L4, a new kallikrein-like gene that appears to be down-regulated in breast cancer tissues
J. Biol. Chem.
275
11891-11898
2000
Homo sapiens (Q9UKR3)
brenda
Kapadia, C.; Ghosh, M.C.; Grass, L.; Diamandis, E.P.
Human kallikrein 13 involvement in extracellular matrix degradation
Biochem. Biophys. Res. Commun.
323
1084-1090
2004
Homo sapiens
brenda
Kapadia, C.; Yousef, G.M.; Mellati, A.A.; Magklara, A.; Wasney, G.A.; Diamandis, E.P.
Complex formation between human kallikrein 13 and serum protease inhibitors
Clin. Chim. Acta
339
157-167
2004
Homo sapiens
brenda
Darling, M.R.; Jackson-Boeters, L.; Daley, T.D.; Diamandis, E.P.
Human kallikrein 13 expression in salivary gland tumors
Int. J. Biol. Markers
21
106-110
2006
Homo sapiens
brenda
Kim, W.S.; Hatsuzawa, K.; Ishizuka, Y.; Hashiba, K.; Murakami, K.; Nakayama, K
A processing enzyme for prorenin in mouse submandibular gland. Purification and characterization
J. Biol. Chem.
265
5930-5933
1990
Mus musculus
brenda
Yao, C.; Karabasil, M.R.; Purwanti, N.; Li, X.; Akamatsu, T.; Kanamori, N.; Hosoi, K.
Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice
J. Biol. Chem.
281
7968-7976
2006
Mus musculus
brenda
Scorilas, A.; Borgono, C.A.; Harbeck, N.; Dorn, J.; Schmalfeldt, B.; Schmitt, M.; Diamandis, E.P.
Human kallikrein 13 protein in ovarian cancer cytosols: a new favorable prognostic marker
J. Clin. Oncol.
22
678-685
2004
Homo sapiens
brenda
Komatsu, N.; Tsai, B.; Sidiropoulos, M.; Saijoh, K.; Levesque, M.A.; Takehara, K.; Diamandis, E.P.
Quantification of eight tissue kallikreins in the Stratum corneum and sweat
J. Invest. Dermatol.
126
925-929
2006
Homo sapiens
brenda
Shaw, J.L.; Diamandis, E.P.
Distribution of 15 human kallikreins in tissues and biological fluids
Clin. Chem.
53
1423-1432
2007
Homo sapiens
brenda
Planque, C.; Blechet, C.; Ayadi-Kaddour, A.; Heuze-Vourch, N.; Dumont, P.; Guyetant, S.; Diamandis, E.P.; El Mezni, F.; Courty, Y.
Quantitative RT-PCR analysis and immunohistochemical localization of the kallikrein-related peptidases 13 and 14 in lung
Biol. Chem.
389
781-786
2008
Homo sapiens
brenda
Planque, C.; Li, L.; Zheng, Y.; Soosaipillai, A.; Reckamp, K.; Chia, D.; Diamandis, E.P.; Goodglick, L.
A multiparametric serum kallikrein panel for diagnosis of non-small cell lung carcinoma
Clin. Cancer Res.
14
1355-1362
2008
Homo sapiens
brenda
Andrade, D.; Assis, D.M.; Santos, J.A.; Alves, F.M.; Hirata, I.Y.; Araujo, M.S.; Blaber, S.I.; Blaber, M.; Juliano, M.A.; Juliano, L.
Substrate specificity of kallikrein-related peptidase 13 activated by salts or glycosaminoglycans and a search for natural substrate candidates
Biochimie
93
1701-1709
2011
Homo sapiens
brenda
Ishige, S.; Kasamatsu, A.; Ogoshi, K.; Saito, Y.; Usukura, K.; Yokoe, H.; Kouzu, Y.; Koike, H.; Sakamoto, Y.; Ogawara, K.; Shiiba, M.; Tanzawa, H.; Uzawa, K.
Decreased expression of kallikrein-related peptidase 13: possible contribution to metastasis of human oral cancer
Mol. Carcinog.
53
557-565
2014
Homo sapiens (Q9UKR3)
-
brenda
Florou, D.; Mavridis, K.; Scorilas, A.
The kallikrein-related peptidase 13 (KLK13) gene is substantially up-regulated after exposure of gastric cancer cells to antineoplastic agents
Tumour Biol.
33
2069-2078
2012
Homo sapiens (Q9UKR3), Homo sapiens
brenda
Gueugnon, F.; Barascu, A.; Mavridis, K.; Petit-Courty, A.; Marchand-Adam, S.; Gissot, V.; Scorilas, A.; Guyetant, S.; Courty, Y.
Kallikrein-related peptidase 13: an independent indicator of favorable prognosis for patients with nonsmall cell lung cancer
Tumor Biol.
36
4979-4986
2015
Homo sapiens (Q9UKR3), Homo sapiens
brenda
Muytjens, C.M.J.; Yu, Y.; Diamandis, E.P.
Functional proteomic profiling reveals KLK13 and TMPRSS11D as active proteases in the lower female reproductive tract
F1000Res.
7
1666
2018
Homo sapiens (Q9UKR3), Homo sapiens
brenda
Gruba, N.; Bielecka, E.; Wysocka, M.; Wojtysiak, A.; Brzezinska-Bodal, M.; Sychowska, K.; Kalinska, M.; Magoch, M.; Pecak, A.; Falkowski, K.; Wisniewska, M.; Sasiadek, L.; Plaza, K.; Kroll, E.; Pejkovska, A.; Rehders, M.; Brix, K.; Dubin, G.; Kantyka, T.; Potempa, J.; Lesner, A.
Development of chemical tools to monitor human kallikrein 13 (KLK13) activity
Int. J. Mol. Sci.
20
1557
2019
Homo sapiens (Q9UKR3), Homo sapiens
brenda