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Information on EC 3.4.21.1 - chymotrypsin and Organism(s) Mus musculus

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.1 chymotrypsin
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This record set is specific for:
Mus musculus
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Preferential cleavage: Tyr-/-, Trp-/-, Phe-/-, Leu-/-
Synonyms
chymotrypsin, alpha-chymotrypsin, bovine alpha-chymotrypsin, chymotrypsin a, alpha-ct, chymotrypsin b, chtp, alpha chymotrypsin, alpha-chymotrypsin a, chymotrypsin ii, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
alpha chymar
-
-
-
-
alpha-chymar ophth
-
-
-
-
alpha-chymotrypsin
-
-
-
-
alpha-chymotrypsin A
-
-
-
-
avazyme
-
-
-
-
chymar
-
-
-
-
chymotest
-
-
-
-
chymotrypsin A
-
-
-
-
chymotrypsin B
-
-
-
-
CTRA
-
-
EC 3.4.4.6
-
-
-
-
enzeon
-
-
-
-
quimar
-
-
-
-
quimotrase
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
9004-07-3
-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
-
chymotrypsinogen B1-deficient mice given cerulein have significant increases in intrapancreatic trypsin activity and develop more severe pancreatitis compared with control mice
metabolism
-
intrapancreatic activation of the digestive proteases trypsin and chymotrypsin is an early event in the development of pancreatitis
physiological function
-
chymotrypsinogen B1 protects against secretagogue-induced pancreatitis by reducing trypsin activity
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CTRB1_MOUSE
263
1
27822
Swiss-Prot
Secretory Pathway (Reliability: 1)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
von Deimling, O.H.; Grning, J.; Gaa, A.
Genetic and biochemical characterization of a new chymotrypsin isozyme of the house mouse, CTRA-1
Biochem. Genet.
29
545-557
1991
Mus musculus
Manually annotated by BRENDA team
Jancso, Z.; Hegyi, E.; Sahin-Toth, M.
Chymotrypsin reduces the severity of secretagogue-induced pancreatitis in mice
Gastroenterology
155
1017-1021
2018
Mus musculus
Manually annotated by BRENDA team