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The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
gamma-glutamyl leukotrienase,
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gamma-glutamyl leukotrienase
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glutathione sulfonic acid + H2O + glycylglycine
? + gamma-glutamyl-glycylglycine
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?
leukotriene C4 + H2O
leukotriene D4 + L-glutamate
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?
oxidized glutathione + H2O + glycylglycine
? + gamma-glutamyl-glycylglycine
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?
reduced glutathione + H2O + glycylglycine
? + gamma-glutamyl-glycylglycine
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?
S-(4-nitro-benzyl)glutathione + H2O + glycylglycine
? + gamma-glutamyl-glycylglycine
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?
S-methylglutathione + H2O + glycylglycine
? + gamma-glutamyl-glycylglycine
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?
additional information
?
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no activity with gamma-glutamyl leucine
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?
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serine-borate
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8fold more potent in inhibiting GGT1 than in inhibiting GGT5
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0.0751
glutathione sulfonic acid
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in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.0102
leukotriene C4
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in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.426
oxidized glutathione
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in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.105
reduced glutathione
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in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.0148
S-(4-nitro-benzyl)glutathione
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in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.0182
S-Methylglutathione
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in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
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GGT1_HUMAN
569
3
61410
Swiss-Prot
Secretory Pathway (Reliability: 1)
GGT5_HUMAN
586
1
62261
Swiss-Prot
Secretory Pathway (Reliability: 1)
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expressed in Pichia pastoris
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Wickham, S.; West, M.; Cook, P.; Hanigan, M.
Gamma-glutamyl compounds: Substrate specificity of gamma-glutamyl transpeptidase enzymes
Anal. Biochem.
414
208-214
2011
Homo sapiens
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