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Information on EC 3.4.19.14 - leukotriene-C4 hydrolase and Organism(s) Homo sapiens

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.19 Omega peptidases
                3.4.19.14 leukotriene-C4 hydrolase
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This record set is specific for:
Homo sapiens
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The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
gamma-glutamyl leukotrienase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
gamma-glutamyl leukotrienase
-
-
GGT5
-
isoform B
PATHWAY SOURCE
PATHWAYS
-
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
glutathione sulfonic acid + H2O + glycylglycine
? + gamma-glutamyl-glycylglycine
show the reaction diagram
-
-
-
-
?
leukotriene C4 + H2O
leukotriene D4 + L-glutamate
show the reaction diagram
-
-
-
-
?
oxidized glutathione + H2O + glycylglycine
? + gamma-glutamyl-glycylglycine
show the reaction diagram
-
-
-
-
?
reduced glutathione + H2O + glycylglycine
? + gamma-glutamyl-glycylglycine
show the reaction diagram
-
-
-
-
?
S-(4-nitro-benzyl)glutathione + H2O + glycylglycine
? + gamma-glutamyl-glycylglycine
show the reaction diagram
-
-
-
-
?
S-methylglutathione + H2O + glycylglycine
? + gamma-glutamyl-glycylglycine
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
no activity with gamma-glutamyl leucine
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
serine-borate
-
8fold more potent in inhibiting GGT1 than in inhibiting GGT5
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0751
glutathione sulfonic acid
-
in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.0102
leukotriene C4
-
in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.426
oxidized glutathione
-
in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.105
reduced glutathione
-
in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.0148
S-(4-nitro-benzyl)glutathione
-
in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
0.0182
S-Methylglutathione
-
in 100 mM Na2HPO4, 3.2 mM KCl, 1.8 mM KH2PO4, and 27.5 mM NaCl, pH 7.4, at 37°C
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
GGT1_HUMAN
569
3
61410
Swiss-Prot
Secretory Pathway (Reliability: 1)
GGT5_HUMAN
586
1
62261
Swiss-Prot
Secretory Pathway (Reliability: 1)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Pichia pastoris
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wickham, S.; West, M.; Cook, P.; Hanigan, M.
Gamma-glutamyl compounds: Substrate specificity of gamma-glutamyl transpeptidase enzymes
Anal. Biochem.
414
208-214
2011
Homo sapiens
Manually annotated by BRENDA team