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Information on EC 3.4.19.12 - ubiquitinyl hydrolase 1 and Organism(s) Rattus norvegicus
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EC Tree
3.4.19.12 ubiquitinyl hydrolase 1Specify your search results
Word Map
- 3.4.19.12
- nerve
- proteasome
- neurodegenerative
- fiber
-
innervation
-
deubiquitinase
-
polyglutamine
- ataxia
- parkinsonism
- spinocerebellar
-
ubiquitin-proteasome
-
polyubiquitinated
- glial
- sars-cov-2
- coronavirus
- covid-19
- calcitonin
- neurofilament
-
fibrillary
-
neuropeptide
-
neuron-specific
-
traumatic
-
gene-related
- cyld
- parkin
-
polyq
-
synaptophysin
-
ubiquitin-like
- polyproteins
- usp7
-
ubiquitin-dependent
- alpha-synuclein
-
deubiquitylating
- npy
-
myenteric
- 3clpro
-
monoubiquitination
- nedd8
-
cd45ro
- isg15
-
intraepidermal
-
k48-linked
- spermatogonial
-
mono-ubiquitinated
-
ubiquitin-binding
-
3c-like
- mers-cov
- medicine
-
isopeptide
- degradation
- synthesis
- diagnostics
-
anti-sars-cov-2
- molecular biology
- analysis
- concussion
- pharmacology
- drug development
The taxonomic range for the selected organisms is: Rattus norvegicus
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
uch-l1, uchl1, ataxin-3, deubiquitinating enzyme, pgp 9.5, usp22, pgp9.5, plpro, otub1, papain-like protease, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
AD-019
-
-
-
-
CGI-70
-
-
-
-
esterase, ubiquitin thiol-
-
-
-
-
hydrolase, ubiquitin carboxyl-terminal
-
-
-
-
hydrolase, ubiquitin carboxyl-terminal (Aplysia californica gene Ap-uch)
-
-
-
-
isopeptidase
-
-
-
-
isopeptidase T
-
-
-
-
Neuron cytoplasmic protein 9.5
-
-
-
-
PGP 9.5
PGP9.5
-
-
-
-
ubiquitin C-terminal hydrolase
-
-
-
-
ubiquitin C-terminal hydrolase (Aplysia californica gene Ap-uch)
-
-
-
-
Ubiquitin C-terminal hydrolase UCH37
-
-
-
-
ubiquitin C-terminal hydrolase-L1
ubiquitin carboxy-terminal hydrolase
-
-
-
-
ubiquitin carboxyl-terminal hydrolase
Ubiquitin thiolesterase
-
-
-
-
Ubiquitin thiolesterase L1
-
-
-
-
Ubiquitin thiolesterase L3
-
-
-
-
Ubiquitin thiolesterase L4
-
-
-
-
Ubiquitin thiolesterase L5
-
-
-
-
ubiquitin-carboxyl-terminal hydrolase PGP-9.5
-
-
-
-
UCH-1
-
-
-
-
UCH-L1
UCH-L2
-
-
-
-
UCH-L3
-
-
-
-
UCH-L4
-
-
-
-
UCH-L5
-
-
-
-
yeast ubiquitin hydrolase
-
-
-
-
YUH1
-
-
-
-
additional information
PGP 9.5
-
-
-
-
ubiquitin carboxyl-terminal hydrolase
-
-
-
-
UCH-L1
-
-
-
-
additional information
-
peptidase classification: clan CA, family C12, Merops ID: C12.001
additional information
-
UCH-L1 belongs to a family of de-ubiquitinating enzymes, comprising of UCH-L1-5
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
189642-63-5
-
86480-67-3
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ubiquitinyl-peptide + H2O
ubiquitin + peptide
-
catalyses the hydrolysis of an ester or amide bond involving the C-terminal Gly76 of ubiquitin
-
-
?
additional information
?
-
-
de novo synthesis of isozyme UCH-L1 in rostral ventrolateral medulla is crucial to survival during mevinphos intoxication, the enzyme is involved in synthesis of ubiquitin which is required for protein targeting in degradation in the ubiquitin-proteasome pathway in neurons, UCH-L1 plays a neuroprotective role
-
-
?
additional information
?
-
de novo synthesis of isozyme UCH-L1 in rostral ventrolateral medulla is crucial to survival during mevinphos intoxication, the enzyme is involved in synthesis of ubiquitin which is required for protein targeting in degradation in the ubiquitin-proteasome pathway in neurons, UCH-L1 plays a neuroprotective role
-
-
?
additional information
?
-
-
overexpression of UCH L1 potentiates ATP-induced currents due to the activation of P2X receptors that are widely distributed in the brain and involved in various biological activities including neurosecretion. UCH-L1 may play an important role in synaptic activity
-
-
?
additional information
?
-
-
UCHL1 can act as a ubiquitin hydrolase, and generate free ubiquitin species from precursor ubiquitin polypeptides. Synaptic activation of UCH-L1 is correlated with an increase in the levels of free monomeric ubiquitin
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
de novo synthesis of isozyme UCH-L1 in rostral ventrolateral medulla is crucial to survival during mevinphos intoxication, the enzyme is involved in synthesis of ubiquitin which is required for protein targeting in degradation in the ubiquitin-proteasome pathway in neurons, UCH-L1 plays a neuroprotective role
-
-
?
additional information
?
-
de novo synthesis of isozyme UCH-L1 in rostral ventrolateral medulla is crucial to survival during mevinphos intoxication, the enzyme is involved in synthesis of ubiquitin which is required for protein targeting in degradation in the ubiquitin-proteasome pathway in neurons, UCH-L1 plays a neuroprotective role
-
-
?
additional information
?
-
-
overexpression of UCH L1 potentiates ATP-induced currents due to the activation of P2X receptors that are widely distributed in the brain and involved in various biological activities including neurosecretion. UCH-L1 may play an important role in synaptic activity
-
-
?
additional information
?
-
-
UCHL1 can act as a ubiquitin hydrolase, and generate free ubiquitin species from precursor ubiquitin polypeptides. Synaptic activation of UCH-L1 is correlated with an increase in the levels of free monomeric ubiquitin
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
LDN-57444
-
i.e. 3-(O-acetyloxime), 5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
2-mercaptoethanol
-
active-site thiol is very sensitive to oxidation and requires reductants
DTT
-
active-site thiol is very sensitive to oxidation and requires reductants
additional information
-
UCH-L1 activity is regulated by synaptic activity. Stimulation of synaptic activity by NMDA/glycine significantly up-regulates UCH-L1 activity in cultured neurons. NMDA-induced up-regulation of UCH-L1 activity is efficiently blocked by pre-treatment of neurons with the NMDA receptor antagonist D-2-amino-5-phosphonopentanoic acid
-
additional information
-
UCH-L1 is significantly elevated in cerebrospinal fluid following controlled cortical impact and middle cerebral artery occlusion, as a model of ischemic stroke, in rats, overview
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
vascular smooth muscle cells. UCH-L1 is up-regulated in injured arteries
-
UCH-L1 is significantly elevated in cerebrospinal fluid following controlled cortical impact and middle cerebral artery occlusion, as a model of ischemic stroke, in rats, overview
-
parietal epithelial cells of Bowman's capsules and some tubular epithelia in the kidney
-
parietal epithelial cells of Bowman's capsules and some tubular epithelia in the kidney
rostral ventrolateral, expression analysis of isozyme UCH-L1 during mevinphos intoxication, overview
-
the olfactory receptor neurones (replaceable) appear to be strongly immunoreactive as do the principal neurones (mitral and mitral/tufted cells), while in the olfactory bulb the replaceable periglomerular and granule cells appear to be non-reactive, distribution in cellular compartments, overview
-
cell culture, expression of UCH-L1 and the regulation of this expression in podocytes, overview
-
UCHL1/PGP 9.5, photoreceptor cells, bipolar cells, and amacrine cells are devoid of staining while the dendrites and axons of both the horizontal cells and the ganglion cells stain strongly
de novo synthesis of UCH-L1, leading to an enhanced dissassembly of ubiquitin-protein conjugates in the rostral ventrolateral medulla, is essential to maintenance of the pro-life phase of mevinphos intoxication via prevention of cardiovascular depression, leading to neuroprotection
additional information
-
high content of UCHL1, distribution in neuron types and cellular compartments, overview
additional information
-
tissue distribution and immunohistochemic analysis, overview
additional information
-
UCH-L1 expression in podocytes is significantly higher in acute proliferative glomerulonephritis, lupus nephritis, membranous glomerulonephritis, and IgA nephropathy than that in focal segmental glomerulosclerosis, minimal change disease, minor abnormality and normal kidney tissues, overview
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
USP19 stabilizes the ubiquitin ligase KPC1 and, like KPC1, it is localized in the cytosol
additional information
-
UCHL1 expression is detected in both soma and dendrites of hippocampal neurons. UCH-L1 is distributed in a micropunctate fashion, localized to dendritic spines of neurons, and partially co-localized with PSD-95, overview
-
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
physiological function
malfunction
-
altered UCH-L1 activity leads to deleterious effects on synapse structure and function. Inhibition of UCH-L1 activity affects synaptic protein clusters
malfunction
UCH-L1 is up-regulated in injured arteries, via posttranscriptional regulation, and local gene delivery of UCH-L1 inhibited vascular lesion formation with suppression of inflammatory responses in vasculature. ERK activation also contributes to the growth inhibitory effect of UCH-L1 in TNFalpha-inflamed vascular smooth muscle cells
physiological function
UCH-L1 appears to be a multi-functional protein and exerts cell type and/or tissue specific actions
physiological function
-
UCH-L1 is one of the major de-ubiquitinating enzymes in the brain which controls ubiquitin homeostasis. UCH-L1 function is required for synaptic plasticity and is itself regulated by synaptic activity. UCH-L1 activity is required for NMDA-induced up-regulation of free monomeric ubiquitin. UCH-L1 can also bind to ubiquitin and act as a ubiquitin stabilizer to prevent its degradation by lysosomes. UCH-L1 regulates spine morphology and density
physiological function
-
UCHL1/PGP 9.5 is important in the ubiquitin system, detailed overview
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). JOS1_RAT
202
0
23178
Swiss-Prot
other Location (Reliability: 2)
UBP4_RAT
961
0
108373
Swiss-Prot
other Location (Reliability: 1)
UCHL1_RAT
223
0
24838
Swiss-Prot
other Location (Reliability: 3)
UCHL3_RAT
230
0
26124
Swiss-Prot
other Location (Reliability: 2)
VCIP1_RAT
1221
0
134566
Swiss-Prot
other Location (Reliability: 3)
UBP28_RAT
1083
0
122688
Swiss-Prot
other Location (Reliability: 1)
UBP2_RAT
618
0
69363
Swiss-Prot
other Location (Reliability: 4)
UBP30_RAT
517
1
58206
Swiss-Prot
Mitochondrion (Reliability: 1)
BAP1_RAT
727
0
80310
Swiss-Prot
other Location (Reliability: 5)
OTUD5_RAT
566
0
60288
Swiss-Prot
other Location (Reliability: 2)
UBP19_RAT
1357
1
150302
Swiss-Prot
other Location (Reliability: 3)
UBP7_RAT
1103
0
128431
Swiss-Prot
other Location (Reliability: 2)
ATX3_RAT
355
0
40446
Swiss-Prot
other Location (Reliability: 1)
OTU1_RAT
343
0
37402
Swiss-Prot
other Location (Reliability: 4)
UBP15_RAT
952
0
109255
Swiss-Prot
other Location (Reliability: 1)
UBP16_RAT
826
0
93762
Swiss-Prot
other Location (Reliability: 2)
ZUP1_RAT
577
0
65722
Swiss-Prot
other Location (Reliability: 1)
DESI2_RAT
194
0
21418
Swiss-Prot
other Location (Reliability: 3)
UBP1_RAT
784
0
87329
Swiss-Prot
other Location (Reliability: 3)
UBP21_RAT
565
0
62700
Swiss-Prot
other Location (Reliability: 4)
UBP46_RAT
366
0
42415
Swiss-Prot
other Location (Reliability: 2)
UBP48_RAT
1036
0
118787
Swiss-Prot
other Location (Reliability: 3)
CYLD_RAT
953
0
106713
Swiss-Prot
other Location (Reliability: 2)
MINY1_RAT
482
0
52729
Swiss-Prot
other Location (Reliability: 1)
OTUB1_RAT
271
0
31270
Swiss-Prot
other Location (Reliability: 1)
UBP10_RAT
794
0
87311
Swiss-Prot
other Location (Reliability: 1)
UBP11_RAT
921
0
105239
Swiss-Prot
other Location (Reliability: 2)
UBP42_RAT
1325
0
146357
Swiss-Prot
other Location (Reliability: 1)
D3ZJJ0_RAT
756
0
84490
TrEMBL
other Location (Reliability: 2)
F1MAA1_RAT
1355
0
154691
TrEMBL
other Location (Reliability: 1)
D4ABI6_RAT
233
0
26335
TrEMBL
other Location (Reliability: 2)
A0A0H2UHD0_RAT
596
0
64009
TrEMBL
Mitochondrion (Reliability: 5)
A0A8I6A6B9_RAT
1047
0
122151
TrEMBL
other Location (Reliability: 3)
G4XKZ2_RAT
2552
0
291854
TrEMBL
other Location (Reliability: 2)
A0A0G2K4S7_RAT
813
0
90445
TrEMBL
other Location (Reliability: 1)
F1LYZ4_RAT
385
0
43830
TrEMBL
other Location (Reliability: 2)
D4A251_RAT
731
0
82447
TrEMBL
other Location (Reliability: 5)
A0A8I6A5X2_RAT
1630
0
184878
TrEMBL
other Location (Reliability: 2)
A0A8I6GL10_RAT
329
0
37634
TrEMBL
other Location (Reliability: 2)
A0A8I5ZV90_RAT
584
0
64048
TrEMBL
other Location (Reliability: 1)
D4A7M3_RAT
392
0
44131
TrEMBL
other Location (Reliability: 4)
A0A8I5ZQ70_RAT
571
0
60732
TrEMBL
other Location (Reliability: 2)
A0A8I6A0C2_RAT
482
0
54578
TrEMBL
other Location (Reliability: 1)
A0A0G2K133_RAT
138
0
15248
TrEMBL
other Location (Reliability: 4)
A0A8I6AS22_RAT
480
0
52367
TrEMBL
other Location (Reliability: 1)
D4AEI6_RAT
872
0
98876
TrEMBL
Mitochondrion (Reliability: 3)
A0A0G2K1U1_RAT
952
0
109241
TrEMBL
other Location (Reliability: 1)
A0A8I6G7I8_RAT
303
0
34798
TrEMBL
Mitochondrion (Reliability: 4)
A0A8I6AAB2_RAT
640
0
67834
TrEMBL
Mitochondrion (Reliability: 5)
A0A1B0GWR2_RAT
2489
0
283227
TrEMBL
other Location (Reliability: 2)
A0A8I6B2I8_RAT
957
0
107849
TrEMBL
other Location (Reliability: 2)
B5DEZ9_RAT
144
0
16368
TrEMBL
other Location (Reliability: 1)
A0A8I5ZSA1_RAT
1078
0
125432
TrEMBL
other Location (Reliability: 1)
A0A8I6GH62_RAT
951
0
107054
TrEMBL
other Location (Reliability: 2)
A0A8I5Y5G4_RAT
164
0
18239
TrEMBL
other Location (Reliability: 2)
A0A8I5ZLA4_RAT
784
0
87325
TrEMBL
other Location (Reliability: 2)
A0A8I6AC85_RAT
907
0
101174
TrEMBL
other Location (Reliability: 1)
D4AD44_RAT
227
0
24979
TrEMBL
other Location (Reliability: 5)
F1M7Q7_RAT
1088
0
120653
TrEMBL
other Location (Reliability: 2)
A0A8I6A1T1_RAT
580
0
64203
TrEMBL
other Location (Reliability: 3)
A0A0G2K5N0_RAT
872
0
95383
TrEMBL
Secretory Pathway (Reliability: 2)
A0A8I6AAW7_RAT
1343
0
153404
TrEMBL
other Location (Reliability: 1)
Q4JL29_RAT
520
0
58906
TrEMBL
other Location (Reliability: 1)
A0A8I5ZVK3_RAT
3583
0
408156
TrEMBL
other Location (Reliability: 2)
D3ZM59_RAT
594
0
66272
TrEMBL
other Location (Reliability: 1)
D4A5S1_RAT
827
0
94128
TrEMBL
other Location (Reliability: 3)
D3ZC84_RAT
2547
0
289440
TrEMBL
other Location (Reliability: 2)
F1LM09_RAT
1084
0
126118
TrEMBL
other Location (Reliability: 1)
A0A8I5Y6Y9_RAT
213
0
23922
TrEMBL
other Location (Reliability: 2)
D3ZWA1_RAT
599
0
65697
TrEMBL
other Location (Reliability: 1)
A0A8I5ZS01_RAT
518
0
57505
TrEMBL
other Location (Reliability: 1)
A0A1W2Q6I2_RAT
333
0
38234
TrEMBL
other Location (Reliability: 5)
A0A8I5ZPC2_RAT
924
0
101731
TrEMBL
other Location (Reliability: 5)
A0A8I5ZZG8_RAT
578
0
63408
TrEMBL
other Location (Reliability: 1)
A0A8I6A351_RAT
506
0
57712
TrEMBL
other Location (Reliability: 2)
A0A8I6B3E6_RAT
1053
1
120867
TrEMBL
other Location (Reliability: 3)
A0A8I6GH56_RAT
3500
0
398610
TrEMBL
other Location (Reliability: 2)
D3ZDI9_RAT
858
0
96748
TrEMBL
Mitochondrion (Reliability: 5)
B0BMY6_RAT
353
0
40447
TrEMBL
other Location (Reliability: 3)
Q5HZY3_RAT
324
0
37097
TrEMBL
other Location (Reliability: 2)
A0A8I6GJ61_RAT
382
0
43364
TrEMBL
other Location (Reliability: 1)
A0A8I5ZY29_RAT
493
0
56025
TrEMBL
other Location (Reliability: 4)
A0A8J8Y1V7_RAT
232
0
26223
TrEMBL
other Location (Reliability: 3)
D3ZJ49_RAT
685
0
78309
TrEMBL
other Location (Reliability: 3)
A0A8I5XVU7_RAT
306
1
35442
TrEMBL
other Location (Reliability: 1)
D3ZTX7_RAT
518
0
59129
TrEMBL
other Location (Reliability: 2)
A0A8I6ARX9_RAT
897
0
100340
TrEMBL
other Location (Reliability: 1)
W8CC82_RAT
2506
0
286598
TrEMBL
other Location (Reliability: 2)
D3ZGY2_RAT
316
0
36274
TrEMBL
other Location (Reliability: 5)
A0A1W2Q6D9_RAT
285
0
32774
TrEMBL
other Location (Reliability: 1)
A1L1I5_RAT
423
0
47803
TrEMBL
other Location (Reliability: 1)
D3ZLQ8_RAT
915
0
102130
TrEMBL
other Location (Reliability: 1)
A0A8I5ZMP6_RAT
524
0
58634
TrEMBL
other Location (Reliability: 2)
A0A0G2JUX4_RAT
1395
0
159609
TrEMBL
other Location (Reliability: 1)
A0A0A0MXZ5_RAT
740
0
81735
TrEMBL
other Location (Reliability: 3)
A0A8I6AEH4_RAT
848
0
95890
TrEMBL
other Location (Reliability: 4)
D3ZNC0_RAT
455
0
49064
TrEMBL
other Location (Reliability: 3)
D4ABZ4_RAT
928
0
101091
TrEMBL
other Location (Reliability: 5)
D3ZAR8_RAT
323
0
37040
TrEMBL
Mitochondrion (Reliability: 3)
A0A0G2K2C7_RAT
2559
0
290791
TrEMBL
other Location (Reliability: 2)
A0A8I5ZZJ8_RAT
1141
0
132559
TrEMBL
Mitochondrion (Reliability: 5)
D3ZX46_RAT
290
0
33779
TrEMBL
other Location (Reliability: 2)
D3ZUR6_RAT
696
0
78745
TrEMBL
Mitochondrion (Reliability: 3)
F1M9B3_RAT
1033
1
118633
TrEMBL
other Location (Reliability: 3)
A0A8I6AGE4_RAT
525
0
58451
TrEMBL
other Location (Reliability: 2)
A0A8I5Y9C9_RAT
468
1
52609
TrEMBL
Secretory Pathway (Reliability: 2)
A0A1W2Q6H1_RAT
126
0
14094
TrEMBL
other Location (Reliability: 3)
A0A0G2JTF5_RAT
2896
0
331084
TrEMBL
other Location (Reliability: 2)
A0A8I6G7R6_RAT
221
0
24565
TrEMBL
other Location (Reliability: 3)
A0A0G2K952_RAT
1503
0
170401
TrEMBL
other Location (Reliability: 2)
M0R851_RAT
914
0
103710
TrEMBL
other Location (Reliability: 1)
D4A4F6_RAT
476
0
53687
TrEMBL
other Location (Reliability: 1)
A0A8I6ABS1_RAT
268
0
30366
TrEMBL
other Location (Reliability: 1)
A0A8I6A2B7_RAT
2519
0
284226
TrEMBL
other Location (Reliability: 1)
A0A8I6A8Q3_RAT
991
0
112767
TrEMBL
other Location (Reliability: 1)
D4A3I0_RAT
734
0
84106
TrEMBL
other Location (Reliability: 2)
A0A8I6A571_RAT
1361
0
155448
TrEMBL
other Location (Reliability: 2)
D3Z916_RAT
444
0
49502
TrEMBL
other Location (Reliability: 3)
A0A8I6GJF0_RAT
146
0
16142
TrEMBL
other Location (Reliability: 5)
A0A8I6A4H0_RAT
81
0
9005
TrEMBL
Mitochondrion (Reliability: 5)
A0A8I6GJY6_RAT
271
0
30386
TrEMBL
other Location (Reliability: 2)
A0A8I6A942_RAT
714
0
80440
TrEMBL
other Location (Reliability: 2)
A0A8I5ZUV8_RAT
587
0
65402
TrEMBL
other Location (Reliability: 2)
F7EK08_RAT
456
0
51683
TrEMBL
Mitochondrion (Reliability: 4)
A0A0G2JVV5_RAT
489
0
55606
TrEMBL
other Location (Reliability: 3)
A0A8I6AMA7_RAT
504
0
56199
TrEMBL
other Location (Reliability: 2)
D3ZGB0_RAT
438
1
49725
TrEMBL
other Location (Reliability: 1)
A0A0A0MY07_RAT
981
0
112345
TrEMBL
other Location (Reliability: 1)
A0A0G2K6U8_RAT
960
0
107451
TrEMBL
other Location (Reliability: 2)
D3ZBB7_RAT
1431
0
161921
TrEMBL
other Location (Reliability: 1)
A0A8I5ZKN3_RAT
123
0
13662
TrEMBL
other Location (Reliability: 5)
M0R7V5_RAT
777
0
87861
TrEMBL
other Location (Reliability: 4)
A0A8I6AG99_RAT
765
0
85153
TrEMBL
other Location (Reliability: 1)
A0A8I6A324_RAT
269
0
31079
TrEMBL
other Location (Reliability: 1)
A0A8I5ZQV2_RAT
717
0
79175
TrEMBL
other Location (Reliability: 1)
A0A8I6A6D3_RAT
361
0
41080
TrEMBL
other Location (Reliability: 2)
A0A0G2K2A5_RAT
331
0
38042
TrEMBL
other Location (Reliability: 2)
A0A0G2JUQ8_RAT
1064
1
122027
TrEMBL
Mitochondrion (Reliability: 3)
A0A1B0GWT2_RAT
2554
0
292084
TrEMBL
other Location (Reliability: 2)
A0A8I6AL23_RAT
814
0
91942
TrEMBL
Mitochondrion (Reliability: 4)
A0A8I5ZT30_RAT
3571
0
406661
TrEMBL
other Location (Reliability: 2)
D4ABE5_RAT
979
0
110147
TrEMBL
other Location (Reliability: 2)
A0A0G2JZU8_RAT
2559
0
292656
TrEMBL
other Location (Reliability: 2)
B2GVC1_RAT
577
0
65830
TrEMBL
other Location (Reliability: 1)
A0A8I6AP58_RAT
1103
0
128431
TrEMBL
other Location (Reliability: 2)
A0A8I6AKU3_RAT
1086
0
126311
TrEMBL
other Location (Reliability: 2)
A0A8I5ZR30_RAT
458
0
52342
TrEMBL
other Location (Reliability: 3)
A0A8I6AE48_RAT
214
0
24376
TrEMBL
other Location (Reliability: 2)
Q5U2N2_RAT
493
0
55977
TrEMBL
other Location (Reliability: 3)
D3ZVQ0_RAT
858
0
95779
TrEMBL
other Location (Reliability: 2)
A0A0G2K3K1_RAT
501
1
56594
TrEMBL
Secretory Pathway (Reliability: 5)
F1LPJ7_RAT
909
0
102781
TrEMBL
other Location (Reliability: 1)
PDB
SCOP
CATH
UNIPROT
ORGANISM
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
C545A
catalytically inactive USP19 mutant, destabilizes ubiquitin ligase KPC1
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
peroxiredoxin II specifically binds to the near-native intermediates (early-unfolding intermediates) of ubiquitin C-terminal hydrolase-L1 to maintain its native state and activity against various stresses rather than preventing deleterious protein aggregation through quaternary structural changes
OXIDATION STABILITY
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
Flag-USP19 transfected into FR3T3 cells. 293VSV cells transfected with pLXSN plasmid encoding N-terminally Flag3-tagged USP19
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
TNFalpha up-regulates UCH-L1via a translational regulation to inhibit ERK activity, thereby providing a negative feedback to control its growth promoting signaling in vascular smooth muscle cells
UCH-L1 expression is significantly decreased in middle cerebral artery occlusion, MCAO, rats
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
diagnostics
-
UCH-L1 is a biomarker for ischemic and traumatic brain injury in rats
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wilkinson, K.D.
Ubiquitin C-terminal hydroase
Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press
660-663
1998
Bos taurus, Drosophila melanogaster, Homo sapiens, Rattus norvegicus
-
Larsen, C.N.; Price, J.S.; Wilkinson, K.D.
Substrate binding and catalysis by ubiquitin C-terminal hydrolases: identification of two active site residues
Biochemistry
35
6735-6744
1996
Bos taurus, Homo sapiens, Mammalia, Rattus norvegicus
Manago, Y.; Kanahori, Y.; Shimada, A.; Sato, A.; Amano, T.; Sato-Sano, Y.; Setsuie, R.; Sakurai, M.; Aoki, S.; Wang, Y.L.; Osaka, H.; Wada, K.; Noda, M.
Potentiation of ATP-induced currents due to the activation of P2X receptors by ubiquitin carboxy-terminal hydrolase L1
J. Neurochem.
92
1061-1072
2005
Homo sapiens, Rattus norvegicus
Chang, C.; Chang, A.Y.W.; Chan, S.H.H.
De novo synthesis of ubiquitin carboxyl-terminal hydrolase isozyme L1 in rostral ventrolateral medulla is crucial to survival during mevinphos intoxication
Shock
22
575-581
2004
Rattus norvegicus, Rattus norvegicus (Q00981)
Lu, Y.; Adegoke, O.A.; Nepveu, A.; Nakayama, K.I.; Bedard, N.; Cheng, D.; Peng, J.; Wing, S.S.
USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1
Mol. Cell. Biol.
29
547-558
2009
Mus musculus (Q3UJD6), Rattus norvegicus (Q6J1Y9)
Ichikawa, T.; Li, J.; Dong, X.; Potts, J.D.; Tang, D.Q.; Li, D.S.; Cui, T.
Ubiquitin carboxyl terminal hydrolase L1 negatively regulates TNFalpha-mediated vascular smooth muscle cell proliferation via suppressing ERK activation
Biochem. Biophys. Res. Commun.
391
852-856
2010
Rattus norvegicus (Q00981)
Liu, M.C.; Akinyi, L.; Scharf, D.; Mo, J.; Larner, S.F.; Muller, U.; Oli, M.W.; Zheng, W.; Kobeissy, F.; Papa, L.; Lu, X.C.; Dave, J.R.; Tortella, F.C.; Hayes, R.L.; Wang, K.K.
Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats
Eur. J. Neurosci.
31
722-732
2010
Rattus norvegicus
Cartier, A.E.; Djakovic, S.N.; Salehi, A.; Wilson, S.M.; Masliah, E.; Patrick, G.N.
Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1
J. Neurosci.
29
7857-7868
2009
Rattus norvegicus
Liu, Y.; Wu, J.; Wu, H.; Wang, T.; Gan, H.; Zhang, X.; Liu, Y.; Li, R.; Zhao, Z.; Chen, Q.; Guo, M.; Zhang, Z.
UCH-L1 expression of podocytes in diseased glomeruli and in vitro
J. Pathol.
217
642-653
2009
Rattus norvegicus
Koh, P.O.
Proteomic analysis of focal cerebral ischemic injury in male rats
J. Vet. Med. Sci.
72
181-185
2010
Rattus norvegicus
Day, I.N.; Thompson, R.J.
UCHL1 (PGP 9.5): neuronal biomarker and ubiquitin system protein
Prog. Neurobiol.
90
327-362
2010
Bos taurus, Homo sapiens, Macaca fuscata, Mus musculus, Rattus norvegicus
Lee, S.P.; Park, C.M.; Kim, K.S.; Kim, E.; Jeong, M.; Shin, J.Y.; Yun, C.H.; Kim, K.; Chock, P.B.; Chae, H.Z.
Structural and biochemical analyses reveal ubiquitin C-terminal hydrolase-L1 as a specific client of the peroxiredoxin II chaperone
Arch. Biochem. Biophys.
640
61-74
2018
Rattus norvegicus (Q00981)
EXTERNAL LINKS (specific for EC-Number 3.4.19.12)
Transporter Classification Database (TCDB): 3.A.31.1.1, 3.A.16.1.2
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