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Information on EC 3.4.19.12 - ubiquitinyl hydrolase 1 and Organism(s) Caenorhabditis elegans

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.19 Omega peptidases
                3.4.19.12 ubiquitinyl hydrolase 1
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This record set is specific for:
Caenorhabditis elegans
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The taxonomic range for the selected organisms is: Caenorhabditis elegans
The enzyme appears in selected viruses and cellular organisms
Synonyms
uch-l1, uchl1, ataxin-3, deubiquitinating enzyme, pgp 9.5, usp22, pgp9.5, plpro, otub1, isopeptidase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
AD-019
-
-
-
-
CGI-70
-
-
-
-
esterase, ubiquitin thiol-
-
-
-
-
hydrolase, ubiquitin carboxyl-terminal
-
-
-
-
hydrolase, ubiquitin carboxyl-terminal (Aplysia californica gene Ap-uch)
-
-
-
-
isopeptidase
-
-
-
-
isopeptidase T
-
-
-
-
Neuron cytoplasmic protein 9.5
-
-
-
-
PGP 9.5
-
-
-
-
PGP9.5
-
-
-
-
ubiquitin C-terminal hydrolase
-
-
-
-
ubiquitin C-terminal hydrolase (Aplysia californica gene Ap-uch)
-
-
-
-
Ubiquitin C-terminal hydrolase UCH37
-
-
-
-
ubiquitin carboxy-terminal hydrolase
-
-
-
-
ubiquitin carboxy-terminal hydrolase L1
-
-
ubiquitin carboxyl terminal hydrolase L1
-
-
ubiquitin carboxyl-terminal hydrolase
-
-
-
-
Ubiquitin thiolesterase
-
-
-
-
Ubiquitin thiolesterase L1
-
-
-
-
Ubiquitin thiolesterase L3
-
-
-
-
Ubiquitin thiolesterase L4
-
-
-
-
Ubiquitin thiolesterase L5
-
-
-
-
ubiquitin-carboxyl-terminal hydrolase PGP-9.5
-
-
-
-
UCH-1
-
-
-
-
UCH-L1
-
-
-
-
UCH-L2
-
-
-
-
UCH-L3
-
-
-
-
UCH-L4
-
-
-
-
UCH-L5
-
-
-
-
yeast ubiquitin hydrolase
-
-
-
-
YUH1
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
189642-63-5
-
86480-67-3
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
linear ubiquitin-beta-galactosidase + H2O
ubiquitin + protein
show the reaction diagram
-
recombinant fusion protein co-expressed with the enzyme in Escherichia coli
-
?
ubiquitin-protein + H2O
ubiquitin + protein
show the reaction diagram
-
enzyme is crucial for polarization of the actin cytoskeleton, to segregate germline determinants, to assemble an intact cleavage furrow, for cytokinesis and to maintain osmotic balance and execute actin-dependent processes in the early embryo
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ubiquitin-protein + H2O
ubiquitin + protein
show the reaction diagram
-
enzyme is crucial for polarization of the actin cytoskeleton, to segregate germline determinants, to assemble an intact cleavage furrow, for cytokinesis and to maintain osmotic balance and execute actin-dependent processes in the early embryo
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
RNAi
-
knockdown of UCHL1, leads to short lifespan of animals and earlier accumulation of aging specific lipofucsin with increasing age when compared with the wild-type
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
early stage
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
UBH4_CAEEL
321
0
37120
Swiss-Prot
other Location (Reliability: 2)
UBPH_CAEEL
1178
0
134123
Swiss-Prot
other Location (Reliability: 3)
UBPY_CAEEL
1276
0
144893
Swiss-Prot
other Location (Reliability: 1)
OTUBL_CAEEL
284
0
32293
Swiss-Prot
other Location (Reliability: 1)
UBP7_CAEEL
1135
0
131597
Swiss-Prot
other Location (Reliability: 1)
ATX3_CAEEL
317
0
35864
Swiss-Prot
other Location (Reliability: 1)
UBP48_CAEEL
1264
0
144457
Swiss-Prot
other Location (Reliability: 2)
UBP14_CAEEL
489
0
55878
Swiss-Prot
other Location (Reliability: 2)
UBP46_CAEEL
426
0
48277
Swiss-Prot
other Location (Reliability: 1)
N1NSE3_CAEEL
1135
0
131528
TrEMBL
other Location (Reliability: 1)
Q9UAV3_CAEEL
216
0
23459
TrEMBL
other Location (Reliability: 2)
G3MU81_CAEEL
1129
0
130955
TrEMBL
other Location (Reliability: 1)
G3MU82_CAEEL
1132
0
131324
TrEMBL
other Location (Reliability: 1)
I2HA92_CAEEL
948
0
107256
TrEMBL
Mitochondrion (Reliability: 3)
Q8MNY0_CAEEL
227
0
25136
TrEMBL
other Location (Reliability: 2)
O45623_CAEEL
1133
0
131356
TrEMBL
other Location (Reliability: 1)
P91502_CAEEL
789
0
88832
TrEMBL
other Location (Reliability: 1)
G3MU83_CAEEL
1134
0
131469
TrEMBL
other Location (Reliability: 1)
Q9N370_CAEEL
379
0
42020
TrEMBL
other Location (Reliability: 1)
N1NTD8_CAEEL
1138
0
131898
TrEMBL
other Location (Reliability: 1)
G3MU80_CAEEL
1132
0
131228
TrEMBL
other Location (Reliability: 1)
U4PEI7_CAEEL
177
0
19406
TrEMBL
other Location (Reliability: 1)
Q8IAA2_CAEEL
173
0
20292
TrEMBL
other Location (Reliability: 2)
Q93875_CAEEL
716
0
82059
TrEMBL
other Location (Reliability: 1)
A0A8D9I6U5_CAEEL
791
0
89059
TrEMBL
other Location (Reliability: 1)
Q965V9_CAEEL
227
0
25253
TrEMBL
other Location (Reliability: 2)
V6CJY2_CAEEL
980
0
112066
TrEMBL
other Location (Reliability: 1)
N1NV07_CAEEL
1136
0
131656
TrEMBL
other Location (Reliability: 1)
Q9BKQ6_CAEEL
474
1
52872
TrEMBL
Secretory Pathway (Reliability: 3)
N1NSD8_CAEEL
1137
0
131770
TrEMBL
other Location (Reliability: 1)
O45624_CAEEL
1130
0
131083
TrEMBL
other Location (Reliability: 1)
G3MU79_CAEEL
1131
0
131196
TrEMBL
other Location (Reliability: 1)
Q9N5M9_CAEEL
910
0
103579
TrEMBL
other Location (Reliability: 1)
N1NTD2_CAEEL
1133
0
131383
TrEMBL
other Location (Reliability: 1)
N1NTI7_CAEEL
1134
0
131496
TrEMBL
other Location (Reliability: 1)
Q22240_CAEEL
1326
0
150189
TrEMBL
other Location (Reliability: 1)
N1NVB4_CAEEL
1132
0
131255
TrEMBL
other Location (Reliability: 1)
Q9GRV2_CAEEL
550
0
62274
TrEMBL
other Location (Reliability: 2)
Q9TYY8_CAEEL
900
0
102646
TrEMBL
other Location (Reliability: 1)
N1NTJ2_CAEEL
1135
0
131624
TrEMBL
other Location (Reliability: 1)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
gene cyk-3 null mutants are lethal, mutants fail to polarize the actin cytoskeleton, to segregate germline determinants, to assemble an intact cleavage furrow, and are intrinsically defective in osmotic regulation and cytokinesis, the latter defect can be partially rescued by providing osmotic support
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene cyk-3, chromosome mapping, co-expression of cyk-3 with Doa4p of Saccharomyces cerevisiae and ubiquitin-beta-galactosidase fusion protein in Escherichia coli
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
UCHL1 is related to cellular senescence process
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kaitna, S.; Schnabel, H.; Schnabel, R.; Hyman, A.A.; Glotzer, M.
A ubiquitin C-terminal hydrolase is required to maintain osmotic balance and execute actin-dependent processes in the early C. elegans embryo
J. Cell Sci.
115
2293-2302
2002
Saccharomyces cerevisiae, Caenorhabditis elegans
Manually annotated by BRENDA team
Ha, M.K.; Soo Cho, J.; Baik, O.R.; Lee, K.H.; Koo, H.S.; Chung, K.Y.
Caenorhabditis elegans as a screening tool for the endothelial cell-derived putative aging-related proteins detected by proteomic analysis
Proteomics
6
3339-3351
2006
Caenorhabditis elegans, Homo sapiens (P09936), Caenorhabditis elegans N2
Manually annotated by BRENDA team