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Information on EC 3.2.1.45 - glucosylceramidase and Organism(s) Sus scrofa

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EC Tree
IUBMB Comments
Also acts on glucosylsphingosine (cf. EC 3.2.1.62 glycosylceramidase).
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Select one or more organisms in this record: ?
This record set is specific for:
Sus scrofa
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The taxonomic range for the selected organisms is: Sus scrofa
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
glucocerebrosidase, imiglucerase, acid beta-glucosidase, beta-glucocerebrosidase, glucosylceramidase, alglucerase, velaglucerase alfa, taliglucerase alfa, cerezyme, glccerase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
acid beta-glucosidase
-
-
-
-
Alglucerase
-
-
-
-
beta-D-glucocerebrosidase
-
-
-
-
beta-glucocerebrosidase
-
-
-
-
beta-glucosylceramidase
-
-
-
-
ceramidase, glucosyl-
-
-
-
-
ceramide glucosidase
-
-
-
-
cerebroside beta-glucosidase
-
-
-
-
D-glucosyl-N-acylsphingosine glucohydrolase
-
-
-
-
glcCer-beta-glucosidase
-
-
-
-
glucocerebrosidase
-
-
-
-
glucocerebroside beta-glucosidase
-
-
-
-
glucose cerebrosidase
-
-
-
-
glucosphingosine glucosylhydrolase
-
-
-
-
glucosylceramide beta-glucosidase
-
-
-
-
glucosylcerebrosidase
-
-
-
-
glucosylsphingosine beta-D-glucosidase
-
-
-
-
glucosylsphingosine beta-glucosidase
-
-
-
-
Imiglucerase
-
-
-
-
psychosine hydrolase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of O-glycosyl bond
-
-
-
-
PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
D-glucosyl-N-acylsphingosine glucohydrolase
Also acts on glucosylsphingosine (cf. EC 3.2.1.62 glycosylceramidase).
CAS REGISTRY NUMBER
COMMENTARY hide
37228-64-1
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-methylumbelliferyl-beta-D-glucopyranoside + H2O
methylumbelliferone + glucose
show the reaction diagram
-
-
-
-
?
glucocerebroside + H2O
glucose + ceramide
show the reaction diagram
-
-
-
-
?
nonylumbelliferyl-beta-D-glucopyranoside + H2O
nonylumbelliferone + glucose
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
glucocerebroside + H2O
glucose + ceramide
show the reaction diagram
-
-
-
-
?
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
GLCM_PIG
536
0
59874
Swiss-Prot
other Location (Reliability: 4)
A0A4X1W0Q8_PIG
536
0
59860
TrEMBL
other Location (Reliability: 4)
A0A8D1R5A7_PIG
885
0
99441
TrEMBL
other Location (Reliability: 1)
A0A4X1VPW3_PIG
915
0
103052
TrEMBL
other Location (Reliability: 1)
Q70KG9_PIG
8
0
1019
TrEMBL
other Location (Reliability: 1)
F1RGS2_PIG
536
0
59860
TrEMBL
other Location (Reliability: 4)
A0A480Y265_PIG
855
0
96677
TrEMBL
other Location (Reliability: 2)
A0A8D1LD14_PIG
903
0
101597
TrEMBL
other Location (Reliability: 1)
A0A8D1UQM0_PIG
915
0
103040
TrEMBL
other Location (Reliability: 1)
A0A480IK32_PIG
425
0
47399
TrEMBL
other Location (Reliability: 4)
A0A4X1VZG6_PIG
490
0
54572
TrEMBL
other Location (Reliability: 4)
A0A8D0TSV2_PIG
884
0
99446
TrEMBL
other Location (Reliability: 1)
Q70KH1_PIG
71
0
7657
TrEMBL
other Location (Reliability: 4)
A0A8D0X9Z8_PIG
863
0
97234
TrEMBL
other Location (Reliability: 1)
F1STB6_PIG
915
0
103052
TrEMBL
other Location (Reliability: 1)
A0A5G2R4K3_PIG
487
0
54570
TrEMBL
other Location (Reliability: 4)
A0A4X1W048_PIG
487
0
54570
TrEMBL
other Location (Reliability: 4)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
56000
-
gel filtration, SDS-PAGE
63000
-
-
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
freezing destroys activity
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
comparative and genetic analysis of the porcine glucocerebrosidase gene
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schliemann, W.; Schliemann, B.
beta-D-Glucosidasen (EC 3.2.1.21) und glucosylceramidasen (EC 3.2.1.45) des Menschen
Pharmazie
4
243-250
1982
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Daniels, L.B.; Glew, R.H.
beta-D-Glucosidases in tissue
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
4
217-226
1984
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
-
Manually annotated by BRENDA team
Pirruccello, S.; Barranger, J.A.; Barton, N.W.; Brady, R.O.; Ginns, E.I.
Molecular weight characterization of beta-D-glucocerebrosidase in mononuclear white blood cells in Gaucher s disease
Biochem. Med.
31
73-79
1984
Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Legler, G.
beta-Glucocerebrosidase: mechanistic studies with covalent and non-covalent inhibitors
NATO ASI Ser. A, Life Sci.
150
63-72
1988
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
-
Manually annotated by BRENDA team
Stratil, A.; Wagenknecht, D.; van Poucke, M.; Kubickova, S.; Bartenschlager, H.; Musilova, P.; Rubes, J.; Geldermann, H.; Peelman, L.J.
Comparative and genetic analysis of the porcine glucocerebrosidase (GBA) gene
Comp. Biochem. Physiol. B
138B
377-383
2004
Sus scrofa (Q70KH2)
-
Manually annotated by BRENDA team