Information on EC 3.2.1.33 - amylo-alpha-1,6-glucosidase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Mark a special word or phrase in this record:
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY
3.2.1.33
-
RECOMMENDED NAME
GeneOntology No.
amylo-alpha-1,6-glucosidase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
hydrolysis of O-glycosyl bond
-
-
endoglycosidic
-
PATHWAY
KEGG Link
MetaCyc Link
glycogen degradation I
-
glycogen degradation II
-
Starch and sucrose metabolism
-
SYSTEMATIC NAME
IUBMB Comments
glycogen phosphorylase-limit dextrin 6-alpha-glucohydrolase
This enzyme hydrolyses an unsubstituted (1->4)-linked glucose chain. The enzyme activity found in mammals and yeast is in a polypeptide chain containing two active centres. The other activity is similar to that of EC 2.4.1.25 (4-alpha-glucanotransferase), which acts on the glycogen phosphorylase limit dextrin chains to expose the single glucose residues, which the 6-alpha-glucosidase activity can then hydrolyse. Together, these two activities constitute the glycogen debranching system.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
1,4-glucan-4-glucosyltransferase/amylo-1,6-glucosidase
-
-
-
-
4-alpha-glucano-transferase amylo-1,6-glucosidase
-
-
-
-
alpha-(1,6)-glucosidase
-
-
-
-
amylo-1,6-glucosidase
-
-
-
-
amylo-1,6-glucosidase
-
part of the multifunctional glycogen debranching enzyme
amylo-1,6-glucosidase
-
part of the putative glycogen-debranching enzyme SSGDE
amylo-1,6-glucosidase
-
-
amylo-1,6-glucosidase-oligo-1,4-1,4-transferase
-
-
-
-
amylo-1,6-glucosidase/1,4-alpha-glucan 4-alpha-glucan 4-alpha-glycosyltransferase
-
-
-
-
amylo-1,6-glucosidase/1,4-alpha-glucan:1,4-alpha-glucan 4-alpha-glycosyltransferase
-
-
-
-
amylo-1,6-glucosidase/4-alpha-glucanotransferase
-
-
-
-
amylo-1,6-glucosidase/oligo-1,4-1,4-glucantransferase
-
-
-
-
amylo-alpha-1,6-glucosidase
-
part of the glycogen debranching enzyme
amylo-alpha-1,6-glucosidase
-
-
amylo-alpha-1,6-glucosidase
-
part of the glycogen debranching enzyme
amylo-alpha-1,6-glucosidase activity
-
-
amylopectin 1,6-glucosidase
-
-
-
-
debrancher enzyme
-
-
-
-
debrancher protein
-
-
-
-
dextrin 6-alpha-D-glucosidase
-
-
-
-
dextrin 6-alpha-glucosidase
-
-
-
-
dextrin 6-alpha-glucosidase
-
-
dextrin 6-alpha-glucosidase
-
part of the glycogen debranching enzyme, hydrolyzes dextrins with the structure Glc-alpha-1,4-(Glc-alpha-1,6)Glc-alpha-1,4-Glc to D-glucose and the corresponding pyridylamino-maltooligosaccharides
dextrin 6-glucanohydrolase
-
-
-
-
dextrin 6-glucohydrolase
-
-
-
-
dextrin-1,6-glucosidase
-
-
-
-
dextrin:6-glucohydrolase
-
-
-
-
GDE amylo-alpha-1,6-glucosidase
-
part of the 170000 Da multifunctional glycogen debranching enzyme (GDE)
GlgX
P15067
-
glucosidase, amylo-1,6-
-
-
-
-
glucosidase/transferase
-
-
-
-
glycogen debranching enzyme
-
-
-
-
glycogen debranching enzyme
-
-
glycogen debranching enzyme
-
-
glycogen debranching enzyme
Nostoc punctiforme PCC73102
-
-
-
glycogen debranching enzyme
-
-
glycogen debranching enzyme
-
exhibits 4-alpha-glucanotransferase and amylo-alpha-1,6-glucosidase activities
glycogen debranching system
-
EC 3.2.1.33 found in mammals and yeast is in a single polypeptide chain containing two active centres. The other activity is similar to that of EC 2.4.1.25, 4-alpha-glucanotransferase, which acts on the glycogen phosphorylase limit dextrin chains to expose the single glucose residues, which the 6-alpha-glucosidase activity can hydrolyse. Together, these two activities constitute the glycogen debranching system
glycogen debranching system
-
EC 3.2.1.33 found in mammals and yeast is in a single polypeptide chain containing two active centres. The other activity is similar to that of EC 2.4.1.25, 4-alpha-glucanotransferase, which acts on the glycogen phosphorylase limit dextrin chains to expose the single glucose residues, which the 6-alpha-glucosidase activity can hydrolyse. Together, these two activities constitute the glycogen debranching system
glycogen debranching system
-
EC 3.2.1.33 found in mammals and yeast is in a single polypeptide chain containing two active centres. The other activity is similar to that of EC 2.4.1.25, 4-alpha-glucanotransferase, which acts on the glycogen phosphorylase limit dextrin chains to expose the single glucose residues, which the 6-alpha-glucosidase activity can hydrolyse. Together, these two activities constitute the glycogen debranching system
glycogen debranching system
-
EC 3.2.1.33 found in mammals and yeast is in a single polypeptide chain containing two active centres. The other activity is similar to that of EC 2.4.1.25, 4-alpha-glucanotransferase, which acts on the glycogen phosphorylase limit dextrin chains to expose the single glucose residues, which the 6-alpha-glucosidase activity can hydrolyse. Together, these two activities constitute the glycogen debranching system
glycogen debranching system
-
EC 3.2.1.33 found in mammals and yeast is in a single polypeptide chain containing two active centres. The other activity is similar to that of EC 2.4.1.25, 4-alpha-glucanotransferase, which acts on the glycogen phosphorylase limit dextrin chains to expose the single glucose residues, which the 6-alpha-glucosidase activity can hydrolyse. Together, these two activities constitute the glycogen debranching system
glycogen debranching system
-
EC 3.2.1.33 found in mammals and yeast is in a single polypeptide chain containing two active centres. The other activity is similar to that of EC 2.4.1.25, 4-alpha-glucanotransferase, which acts on the glycogen phosphorylase limit dextrin chains to expose the single glucose residues, which the 6-alpha-glucosidase activity can hydrolyse. Together, these two activities constitute the glycogen debranching system
glycogen debranching system
-
EC 3.2.1.33 found in mammals and yeast is in a single polypeptide chain containing two active centres. The other activity is similar to that of EC 2.4.1.25, 4-alpha-glucanotransferase, which acts on the glycogen phosphorylase limit dextrin chains to expose the single glucose residues, which the 6-alpha-glucosidase activity can hydrolyse. Together, these two activities constitute the glycogen debranching system
glycogen debranching system
-
EC 3.2.1.33 found in mammals and yeast is in a single polypeptide chain containing two active centres. The other activity is similar to that of EC 2.4.1.25, 4-alpha-glucanotransferase, which acts on the glycogen phosphorylase limit dextrin chains to expose the single glucose residues, which the 6-alpha-glucosidase activity can hydrolyse. Together, these two activities constitute the glycogen debranching system
glycogen phosphorylase dextrin 6-glucanohydrolase
-
-
glycogen phosphorylase limit dextrin alpha-1,6-glucohydrolase
-
-
glycogen phosphorylase limit dextrin debranching system
-
-
-
-
indirect debranching enzyme
-
-
-
-
NPDE
Nostoc punctiforme PCC73102
-
-
-
oligo-alpha-1,4-glucan:alpha-1,4-glucan-4-glycosyltransferase-amylo-1,6-glucosidase
-
-
-
-
SSO2094
Q7LX99
locus name
SSO2094
Q7LX99
locus name; locus name
-
transferase-glucosidase
-
-
-
-
TreX
Q7LX99
;
-
CAS REGISTRY NUMBER
COMMENTARY
9012-47-9
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
member of glycosyl hydrolase 13 family
UniProt
Manually annotated by BRENDA team
healthy and patient with type III glycogen storage disease
-
-
Manually annotated by BRENDA team
patients with Glycogen Storage Disease Type III. Bifunctional amylo-1,6-glucosidase and 4-alpha-glucanotransferase, protein possesses two separate domains for the transferase and glucosidase activities
Uniprot
Manually annotated by BRENDA team
patients with type I and type III glycogen storage disease and control patient
-
-
Manually annotated by BRENDA team
generally present in mammalian tissues
-
-
Manually annotated by BRENDA team
strain PCC73102
-
-
Manually annotated by BRENDA team
Nostoc punctiforme PCC73102
strain PCC73102
-
-
Manually annotated by BRENDA team
2 enzymes: acidic and neutral
-
-
Manually annotated by BRENDA team
bifunctional amylo-1,6-glucosidase and oligo-1,4-1,4 glucanotransferase
-
-
Manually annotated by BRENDA team
D-346, ATCC 56960
-
-
Manually annotated by BRENDA team
expression in Escherichia coli
-
-
Manually annotated by BRENDA team
pacific dogfish
-
-
Manually annotated by BRENDA team
strain ATCC 51178
-
-
Manually annotated by BRENDA team
bifunctional amylo-1,6-glucosidase and 4-alpha-glucanotransferase
UniProt
Manually annotated by BRENDA team
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Ba2+
-
1 mM, 154% of initial activity
Ba2+
-
41.7% increase of activity at 5 mM
Ca2+
-
27.3% increase of activity at 5 mM
Co2+
-
15% increase of activity at 5 mM
Fe2+
-
40.6% increase of activity at 5 mM
Mg2+
-
17.2% increase of activity at 5 mM
Mn2+
-
62.2% increase of activity at 5 mM
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
no modification
-
no covalently bound phosphate or carbohydrate, method would not have detected less than 5% carbohydrate
pH STABILITY
pH STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
ORGANIC SOLVENT
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Ethanol
-
stable in ethanol precipitation with final concentration of 23% ethanol