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Information on EC 3.2.1.28 - alpha,alpha-trehalase and Organism(s) Homo sapiens

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EC Tree
IUBMB Comments
The enzyme is an anomer-inverting glucosidase that catalyses the hydrolysis of the alpha-glucosidic O-linkage of alpha,alpha-trehalose, releasing initially equimolar amounts of alpha- and beta-D-glucose. It is widely distributed in microorganisms, plants, invertebrates and vertebrates.
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This record set is specific for:
Homo sapiens
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
trehalase, neutral trehalase, acid trehalase, soluble trehalase, tre-2, nth1p, alpha,alpha-trehalase, setre-2, atc1p, ntp1p, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
alpha,alpha'-trehalose 1-D-glucohydrolase
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-
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Alpha,alpha-trehalase
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-
-
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Alpha,alpha-trehalose glucohydrolase
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-
-
-
trehalase
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of O-glycosyl bond
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
alpha,alpha-trehalose glucohydrolase
The enzyme is an anomer-inverting glucosidase that catalyses the hydrolysis of the alpha-glucosidic O-linkage of alpha,alpha-trehalose, releasing initially equimolar amounts of alpha- and beta-D-glucose. It is widely distributed in microorganisms, plants, invertebrates and vertebrates.
CAS REGISTRY NUMBER
COMMENTARY hide
9025-52-9
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
alpha,alpha-trehalose + H2O
beta-D-glucose + alpha-D-glucose
show the reaction diagram
i.e. alpha-D-glucopyranosyl-1,1-alpha-D-glucopyranoside
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-
?
trehalose + H2O
D-glucose
show the reaction diagram
-
-
-
?
additional information
?
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-
human trehalase Treh acts as a stress-response protein in the kidney rather than being involved in utilization of exogenous trehalose
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?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
alpha,alpha-trehalose + H2O
beta-D-glucose + alpha-D-glucose
show the reaction diagram
i.e. alpha-D-glucopyranosyl-1,1-alpha-D-glucopyranoside
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-
?
additional information
?
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-
human trehalase Treh acts as a stress-response protein in the kidney rather than being involved in utilization of exogenous trehalose
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
activity is low in the healthy infants and elevated in patients with asphyxia. Markedly high activity is observed in patients with Lowe syndrome. Increase of urinary trehalase reflects the extent of renal tubular damage
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
trehalase function is central in carbon partitioning and energy homeostasis regulation
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
TREA_HUMAN
583
0
66568
Swiss-Prot
Secretory Pathway (Reliability: 1)
B3KRP3_HUMAN
460
0
51728
TrEMBL
other Location (Reliability: 5)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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expression in Saccharomyces cerevisiae mutant lacking the endogenous trehalase nth1 does not rescue its dysfunction or enable the mutant to grow on trehalose. Expression in Saccharomyces cerevisiae trehalase mutants nth1 or ath1 does not rescue their sensitivity to heat, osmotic stress, or oxidative stress
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Saccharomyces cerevisiae lacking the activites of endogenous trehalases Nth1, Nth2, or Ath1
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sasai-Takedatsu, M.; Taketani, S.; Nagata, N.; Furukawa, T.; Tokunaga, R.; Kojima, T.; Kobayashi, Y.
Human trehalase: characterization, localization, and its increase in urine by renal proximal tubular damage
Nephron
73
179-185
1996
Homo sapiens
Manually annotated by BRENDA team
Ouyang, Y.; Xu, Q.; Mitsui, K.; Motizuki, M.; Xu, Z.
Human trehalase is a stress responsive protein in Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
379
621-625
2009
Homo sapiens
Manually annotated by BRENDA team
Buts, J.P.; Stilmant, C.; Bernasconi, P.; Neirinck, C.; De Keyser, N.
Characterization of alpha,alpha-trehalase released in the intestinal lumen by the probiotic Saccharomyces boulardii
Scand. J. Gastroenterol.
43
1489-1496
2008
Homo sapiens, Saccharomyces boulardii (nom. inval.)
Manually annotated by BRENDA team
Barraza, A.; Sanchez, F.
Trehalases: a neglected carbon metabolism regulator?
Plant Signal. Behav.
8
e24778
2013
Apis mellifera (A8J4S9), Arabidopsis thaliana (Q9SU50), Aspergillus nidulans (O42777), Caenorhabditis elegans (Q9GYK9), Candida albicans (P52494), Drosophila melanogaster (Q9W2M2), Enterobacter sp. (A4WBE4), Enterobacter sp. 638 (A4WBE4), Erwinia amylovora (D4I261), Escherichia coli (P13482), Glycine max (Q9XEY7), Homo sapiens (O43280), Laccaria bicolor (B0CV22), Laccaria bicolor (B0DA99), Medicago truncatula (Q9XGH9), Metarhizium acridum (Q6Q5X7), Metarhizium anisopliae (A9XE63), Mus musculus (Q9JLT2), Neurospora crassa (O42783), Neurospora crassa DSM 1257 (O42783), Neurospora tetrasperma (F8MBS5), Nicotiana tabacum (D2KWM9), Physcomitrium patens (A6MIZ4), Ralstonia solanacearum, Rattus norvegicus (O70282), Saccharomyces cerevisiae (P48016), Spodoptera exigua (B0M0J3), Spodoptera frugiperda (B5ATV4), Xanthomonas campestris (Q3BXX2)
Manually annotated by BRENDA team