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Information on EC 3.2.1.23 - beta-galactosidase and Organism(s) Homo sapiens
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EC Tree
3.2.1.23 beta-galactosidaseIUBMB Comments
Some enzymes in this group hydrolyse alpha-L-arabinosides; some animal enzymes also hydrolyse beta-D-fucosides and beta-D-glucosides; cf. EC 3.2.1.108 lactase.
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Word Map
- 3.2.1.23
- lacz
- adenovirus
- lysosomal
- lactose
- endothelial
- oligosaccharide
- artery
- phage
-
adenovirus-mediated
- beta-glucosidase
-
immunoassay
-
retroviral
- beta-glucuronidase
-
herpes
- lambda
- simplex
- luciferase
- cytomegalovirus
- neuraminidase
- viruses
- hydrolases
- bacteriophage
- glycosidases
- gm1
- liposome
- ganglioside
- p16ink4a
- alpha-galactosidase
- alpha-mannosidase
-
osteogenic
- vaccinia
-
adeno-associated
-
replication-defective
- n-acetyl-beta-glucosaminidase
- runx2
- sialidase
- alpha-glucosidase
-
sialic
-
galactosylation
-
plaque-forming
-
osteoblast
- kluyveromyces
- telomerase
- analysis
- degradation
- diagnostics
-
lysogens
- beta-hexosaminidase
- keratan
-
vector-mediated
- biotechnology
- molecular biology
- synthesis
- environmental protection
- ganciclovir
- nutrition
-
transglycosylation
- medicine
- industry
-
nonviral
- food industry
- biofuel production
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
beta-galactosidase, beta-gal, beta-d-galactosidase, senescence-associated beta-galactosidase, endo-beta-galactosidase, bglap, sa-beta-gal, acid beta-galactosidase, beta galactosidase, betagal, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Acid beta-galactosidase
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-
-
-
beta-D-galactoside galactohydrolase
-
-
-
-
beta-D-glactanase
-
-
-
-
beta-D-lactosidase
-
-
-
-
beta-galase
-
-
-
-
beta-lactosidase
-
-
-
-
driselase
-
-
-
-
Exo-(1-->4)-beta-D-galactanase
-
-
-
-
exo-beta-(1->3)-D-galactanase
-
-
-
-
galactosidase, beta
-
-
-
-
Hydrolact
-
-
-
-
lactase
-
-
-
-
lactosylceramidase II
-
-
-
-
Lactozym
-
-
-
-
Maxilact
-
-
-
-
Oryzatym
-
-
-
-
p-nitrophenyl beta-galactosidase
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-
-
-
S 2107
-
-
-
-
SR12 protein
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-
-
-
Sumiklat
-
-
-
-
Trilactase
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of O-glycosyl bond
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-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
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-
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SYSTEMATIC NAME
IUBMB Comments
beta-D-galactoside galactohydrolase
Some enzymes in this group hydrolyse alpha-L-arabinosides; some animal enzymes also hydrolyse beta-D-fucosides and beta-D-glucosides; cf. EC 3.2.1.108 lactase.
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CAS REGISTRY NUMBER
COMMENTARY
9031-11-2
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-methylumbelliferyl beta-D-galactoside + H2O
4-methylumbelliferone + beta-D-galactose
-
-
-
-
?
5-bromo-4-chloro-3-indolyl-beta-D-galactopyranoside + H2O
5-bromo-4-chloroindol + beta-D-galactopyranose
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-
-
-
?
5-bromo-4-chloro-3-indolyl-beta-D-galactoside + H2O
5-bromo-4-chloroindol + beta-D-galactose
-
-
-
-
?
o-nitrophenyl-beta-D-galactoside + H2O
o-nitrophenol + beta-D-galactose
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-
-
-
?
p-nitrophenyl-beta-D-galactoside + H2O
p-nitrophenol + beta-D-galactose
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-
-
-
?
additional information
?
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-
patients with type 1 HM1 gangliosidosis (mutation D332N on one allele and mutation S532G on the other allele) have less than 1% residual beta-galactosidase activity and minimal detectable levels of immunoreactive beta-galactosidase protein in fibroblasts. Most of the missense mutations described in GM1 gangliosidosis have little effect on catalytic activity, but do affect protein conformation such that the resulting protein cannot be transported out of the ER and fails to arrive in the lysosome. This accounts for the minimal amounts of the enzyme protein and activity seen in most GM1 gangliosidosis patient fibroblast
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-
?
additional information
?
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-
the enzyme activity is correlated with the senescence of cells, overview
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-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
patients with type 1 HM1 gangliosidosis (mutation D332N on one allele and mutation S532G on the other allele) have less than 1% residual beta-galactosidase activity and minimal detectable levels of immunoreactive beta-galactosidase protein in fibroblasts. Most of the missense mutations described in GM1 gangliosidosis have little effect on catalytic activity, but do affect protein conformation such that the resulting protein cannot be transported out of the ER and fails to arrive in the lysosome. This accounts for the minimal amounts of the enzyme protein and activity seen in most GM1 gangliosidosis patient fibroblast
-
-
?
additional information
?
-
-
the enzyme activity is correlated with the senescence of cells, overview
-
-
?
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acantholysis
Autoantibodies against the amino-terminal cadherin-like binding domain of pemphigus vulgaris antigen are pathogenic.
Acidosis
Acidosis and increased plasma levels of beta-D-glucosidase and beta-D-galactosidase after hepatic inflow occlusion in the pig.
Acidosis
Ca(2+)/calmodulin-dependent protein kinase II contributes to intracellular pH recovery from acidosis via Na(+)/H(+) exchanger activation.
Acidosis, Renal Tubular
Coordinately increased lysozymuria and lysosomal enzymuria induced by maleic acid.
Acquired Immunodeficiency Syndrome
Diagnosis of HIV-1 infection with whole saliva by detection of antibody IgG to HIV-1 with ultrasensitive enzyme immunoassay using recombinant reverse transcriptase as antigen.
Acquired Immunodeficiency Syndrome
Immune complex transfer enzyme immunoassay for antibody IgG to HIV-1 gp41 antigen using synthetic peptides as antigens.
Acquired Immunodeficiency Syndrome
Modification of sweet acidophilus milk to improve utilization by lactose-intolerant persons.
Acquired Immunodeficiency Syndrome
Reactivity of E. coli-derived trans-activating protein of human T lymphotropic virus type III with sera from patients with acquired immune deficiency syndrome.
Acute Kidney Injury
Mechanisms and consequences of oxidant-induced renal preconditioning: an Nrf2-dependent, P21-independent, anti-senescence pathway.
Adenocarcinoma
Adenovirus-mediated E2F-1 gene transfer induces an apoptotic response in human gastric carcinoma cells that is enhanced by cyclin dependent kinase inhibitors.
Adenocarcinoma
Alteration in glycosidases from well-differentiated colorectal adenocarcinoma of rat.
Adenocarcinoma
BGLAP is expressed in pancreatic cancer cells and increases their growth and invasion.
Adenocarcinoma
E2F-1 gene therapy induces apoptosis and increases chemosensitivity in human pancreatic carcinoma cells.
Adenocarcinoma
Glucocorticoid-like effects of antihepatocarcinogen Rotenone are mediated via enhanced serum corticosterone levels: Molecular Fitting and Receptor Activation Studies.
Adenocarcinoma
Growth characteristics in the initial stage of micrometastasis formation by bacterial LacZ gene-tagged rat prostatic adenocarcinoma cells.
Adenocarcinoma
Highly attenuated modified vaccinia virus Ankara (MVA) as an effective recombinant vector: a murine tumor model.
Adenocarcinoma
Human Barrett's Adenocarcinoma of the Esophagus, Associated Myofibroblasts, and Endothelium Can Arise from Bone Marrow-Derived Cells After Allogeneic Stem Cell Transplant.
Adenocarcinoma
IL-12 is an effective adjuvant to recombinant vaccinia virus-based tumor vaccines: enhancement by simultaneous B7-1 expression.
Adenocarcinoma
Preparative in vitro generation of lacto-series type 1 chain glycolipids catalyzed by beta 1----3-galactosyltransferase from human colonic adenocarcinoma Colo 205 cells.
Adenocarcinoma
Production and characterization of monoclonal antibody to a 60-kD glycoprotein in ovarian carcinoma.
Adenocarcinoma
The transmembrane domains of Sindbis virus envelope glycoproteins induce cell death.
Adenocarcinoma
Tumor necrosis factor receptor p75 mediates cell-specific activation of nuclear factor kappa B and induction of human cytomegalovirus enhancer.
Adenocarcinoma
Two CEA cross-reacting antigens: differences in absorbing the same anti-CEA serum.
Adenocarcinoma of Lung
Characterization of the human surfactant protein D promoter: transcriptional regulation of SP-D gene expression by glucocorticoids.
Adenocarcinoma of Lung
Inhibition of oncogenic K-ras signaling by aerosolized gene delivery in a mouse model of human lung cancer.
Adenocarcinoma of Lung
Transforming growth factor beta triggers two independent-senescence programs in cancer cells.
Adenoviridae Infections
Adenovirus-mediated arterial gene transfer does not require prior injury for submaximal gene expression.
Adenoviridae Infections
Development and assessment of a general theory of cervical carcinogenesis utilizing a severe combined immunodeficiency murine-human xenograft model.
Adenoviridae Infections
Light-induced adenovirus gene transfer, an efficient and specific gene delivery technology for cancer gene therapy.
Adenoviridae Infections
Major effects of TPO delivered by a single injection of a recombinant adenovirus on prevention of septicemia and anemia associated with myelosuppression in mice: risk of sustained expression inducing myelofibrosis due to immunosuppression.
Adrenocortical Carcinoma
DAX1 gene expression upregulated by steroidogenic factor 1 in an adrenocortical carcinoma cell line.
Adrenoleukodystrophy
Adrenoleukodystrophy and beta-galactosidase deficiency: patient and carrier.
Adrenoleukodystrophy
Electron microscopic examination of skin and conjunctival biopsy specimens in neuronal storage diseases.
Adrenoleukodystrophy
[A case of adrenoleukodystrophy and a carrier with decreased activity of beta-galactosidase]
African Swine Fever
Genetic manipulation of African swine fever virus: construction of recombinant viruses expressing the beta-galactosidase gene.
AIDS-Related Complex
Diagnosis of HIV-1 infection with whole saliva by detection of antibody IgG to HIV-1 with ultrasensitive enzyme immunoassay using recombinant reverse transcriptase as antigen.
AIDS-Related Complex
Immune complex transfer enzyme immunoassay for antibody IgG to HIV-1 gp41 antigen using synthetic peptides as antigens.
Albuminuria
Urinary glycosaminoglycans, sialic acid and lysosomal enzymes increase in nonalbuminuric diabetic patients.
alpha-Mannosidosis
Measurement of Elevated Concentrations of Urine Keratan Sulfate by UPLC-MSMS in Lysosomal Storage Disorders (LSDs): Comparison of Urine Keratan Sulfate Levels in MPS IVA Versus Other LSDs.
alpha-n-acetylglucosaminidase deficiency
The atomic model of the human protective protein/cathepsin A suggests a structural basis for galactosialidosis.
Alzheimer Disease
Cerebrospinal fluid beta-glucocerebrosidase activity is reduced in Dementia with Lewy Bodies.
Anemia
Anomalous cell surface structure of sickle cell anemia erythrocytes as demonstrated by cell surface labeling and endo-beta-galactosidase treatment.
Anemia
Highly efficient EIAV-mediated in utero gene transfer and expression in the major muscle groups affected by Duchenne muscular dystrophy.
Anemia
Long-term transgene expression by administration of a lentivirus-based vector to the fetal circulation of immuno-competent mice.
Anemia, Dyserythropoietic, Congenital
Defect in glycosylation of erythrocyte membrane proteins in congenital dyserythropoietic anaemia type II (HEMPAS).
Anemia, Dyserythropoietic, Congenital
Isolation and characterization of poly-N-acetyllactosaminylceramides accumulated in the erythrocytes of congenital dyserythropoietic anemia type II patients.
Anemia, Sickle Cell
Anomalous cell surface structure of sickle cell anemia erythrocytes as demonstrated by cell surface labeling and endo-beta-galactosidase treatment.
Anemia, Sickle Cell
Decreased urinary excretion of beta-glucuronidase in sickle cell anemia in Nigeria.
Aneurysm
Coronary artery aneurysm induced by Kawasaki disease in children show features typical senescence.
Angiofibroma
Cellular senescence of angiofibroma stroma cells from patients with tuberous sclerosis.
Angiokeratoma
beta-Galactosidase and neuraminidase deficiency associated with angiokeratoma corporis diffusum.
Anthrax
Cloning and characterization of a gene whose product is a trans-activator of anthrax toxin synthesis.
Aortic Valve Stenosis
In vivo cardiac gene transfer of Kv4.3 abrogates the hypertrophic response in rats after aortic stenosis.
Appendicitis
Histochemical study of expression of lectin-reactive carbohydrate epitopes and glycoligand-binding sites in normal human appendix vermiformis, colonic mucosa, acute appendicitis and colonic adenoma.
Arteritis
Linking immune-mediated arterial inflammation and cholesterol-induced atherosclerosis in a transgenic mouse model.
Arthritis
Adeno-associated virus pseudotype 5 vector improves gene transfer in arthritic joints.
Arthritis
Adenovirus-based overexpression of tissue inhibitor of metalloproteinases 1 reduces tissue damage in the joints of tumor necrosis factor alpha transgenic mice.
Arthritis
Adenovirus-mediated gene transfer of adiponectin reduces the severity of collagen-induced arthritis in mice.
Arthritis
Adenovirus-mediated gene transfer of CTLA-4Ig fusion protein in the suppression of experimental autoimmune arthritis.
Arthritis
Disease-inducible transgene expression from a recombinant adeno-associated virus vector in a rat arthritis model.
Arthritis
Modifications in adenoviral coat fiber proteins and transcriptional regulatory sequences enhance transgene expression.
Arthritis
[Recombinant adenovirus-mediated gene transfer suppresses experimental arthritis]
Arthritis, Experimental
Adenovirus-mediated gene transfer of adiponectin reduces the severity of collagen-induced arthritis in mice.
Arthritis, Experimental
Direct synovial gene transfer with retroviral vectors in rat adjuvant arthritis.
Arthritis, Rheumatoid
Activity of lysosomal exoglycosidases in serum and synovial fluid in patients with chronic Lyme and rheumatoid arthritis.
Arthus Reaction
Histoenzymology of the lung. II. The behaviour of lung hydrolytic enzymes during some experimental pulmonary processes.
Aspartylglucosaminuria
Measurement of Elevated Concentrations of Urine Keratan Sulfate by UPLC-MSMS in Lysosomal Storage Disorders (LSDs): Comparison of Urine Keratan Sulfate Levels in MPS IVA Versus Other LSDs.
Asthma
[Correlations between lysosomal enzymes and cyclic nucleotides during allergies in children]
Astrocytoma
Expression of p57(KIP2) potently blocks the growth of human astrocytomas and induces cell senescence.
Astrocytoma
Gene transfer in astrocytes: comparison between different delivering methods and expression of the HIV-1 protein Nef.
Astrocytoma
Increased activity of lysosomal glycohydrolases in glioma tissue and surrounding areas from human brain.
Ataxia
Inheritance of an ovine lysosomal storage disease associated with deficiencies of beta-galactosidase and alpha-neuraminidase.
Ataxia
Localized beta-galactosidase deficiency. Occurrence in cerebellar ataxia with myoclonus epilepsy and macular cherry-red spot--a new variant of GM1-gangliosidosis?
Ataxia
Lysosomal enzymes in ataxia: discovery of two new cases of late onset hexosaminidase A and B deficiency (adult Sandhoff disease) in French Canadians.
Ataxia
Macular cherry-red spots and beta-galactosidase deficiency in an adult. An autopsy case with progressive cerebellar ataxia, myoclonus, thrombocytopathy, and accumulation of polysaccharide in liver.
Ataxia Telangiectasia
Cellular response to irinotecan in colon cancer cell lines showing differential response to 5-fluorouracil.
Atrial Fibrillation
Inhibitory G protein overexpression provides physiologically relevant heart rate control in persistent atrial fibrillation.
Autoimmune Diseases
Resting CD8 T cells recognize beta-galactosidase expressed in the immune-privileged retina and mediate autoimmune disease when activated.
Autoimmune Diseases
Retinal expression of a neo-self antigen, beta-galactosidase, is not tolerogenic and creates a target for autoimmune uveoretinitis.
Bacterial Infections
Discovery of new beta-D-galactosidase inhibitors via pharmacophore modeling and QSAR analysis followed by in silico screening.
Bacterial Infections
Identification of immune system and response genes, and novel mutations causing melanotic tumor formation in Drosophila melanogaster.
beta-galactosidase deficiency
A case of GM1-gangliosidosis type I: glycosphingolipid profiles of urine and transformed lymphocytes and beta-D-galactosidase activities in peripheral lymphocytes, cultured skin fibroblasts and transformed lymphocytes.
beta-galactosidase deficiency
A comparative study of sialyloligosaccharides isolated from sialidosis and galactosialidosis urine.
beta-galactosidase deficiency
A family with beta-galactosidase deficiency: three adults with atypical clinical patterns.
beta-galactosidase deficiency
A fluorimetric enzyme assay for the diagnosis of Morquio disease type A (MPS IV A).
beta-galactosidase deficiency
A microassay for acid beta-galactosidase activity toward asialofetuin.
beta-galactosidase deficiency
A quantitative cytochemical assay of beta-galactosidase in single cultured human skin fibroblasts.
beta-galactosidase deficiency
A simple method of lysosomal hydrolase assay in a single somatic cell and its application.
beta-galactosidase deficiency
A spreadable, non-integrative and high copy number shuttle vector for Sulfolobus solfataricus based on the genetic element pSSVx from Sulfolobus islandicus.
beta-galactosidase deficiency
A two-year-old patient with an atypical expression of GM1-beta-galactosidase deficiency: biochemical, immunological, and cell genetic studies.
beta-galactosidase deficiency
Adrenoleukodystrophy and beta-galactosidase deficiency: patient and carrier.
beta-galactosidase deficiency
Adult GM1 gangliosidosis: clinical and biochemical studies on two patients and comparison to other patients called variant or adult GM1 gangliosidosis.
beta-galactosidase deficiency
Application of epithelial cells in culture to the biochemical studies of lysosomal hydrolase deficiencies.
beta-galactosidase deficiency
Atypical adult GM1 gangliosidosis: biochemical comparison with other forms of primary beta-galactosidase deficiency.
beta-galactosidase deficiency
Atypical expression of beta-galactosidase deficiency in a child with Hurler-like features but without neurological abnormalities.
beta-galactosidase deficiency
Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis.
beta-galactosidase deficiency
Beta-galactosidase deficiencies and novel GLB1 mutations in three Chinese patients with Morquio B disease or GM1 gangliosidosis.
beta-galactosidase deficiency
Beta-galactosidase deficiency in a Korat cat: a new form of feline GM1-gangliosidosis.
beta-galactosidase deficiency
beta-Galactosidase deficiency in an adult: a biochemical and somatic cell genetic study on a variant of GM1-gangliosidosis.
beta-galactosidase deficiency
Beta-galactosidase deficiency in GM1 gangliosidosis of Friesian calves.
beta-galactosidase deficiency
beta-Galactosidase deficiency in juvenile and adult patients. Report of six Japanese cases and review of literature.
beta-galactosidase deficiency
beta-Galactosidase deficiency: An approach to chaperone therapy.
beta-galactosidase deficiency
Beta-galactosidase deficiency: prolonged survival in three patients following early central nervous system deterioration.
beta-galactosidase deficiency
Beta-galactosidase deficiency: studies of two patients with prolonged survival.
beta-galactosidase deficiency
Beta-galactosidase-deficient mouse as an animal model for GM1-gangliosidosis.
beta-galactosidase deficiency
Biochemical comparison of the dysmorphic type with the normosomatic type of sialidosis.
beta-galactosidase deficiency
Biochemical, immunological, and structural studies on a sphingolipid activator protein (SAP-1).
beta-galactosidase deficiency
Cardiac involvement in diseases characterized by beta-galactosidase deficiency.
beta-galactosidase deficiency
Carrier detection of sialidosis with partial beta-galactosidase deficiency by the assay of lysosomal sialidase in lymphocytes.
beta-galactosidase deficiency
Chaperone therapy for neuronopathic lysosomal diseases: competitive inhibitors as chemical chaperones for enhancement of mutant enzyme activities.
beta-galactosidase deficiency
Chemical pathology of krabbe's disease. IV. Studies of galactosylceramide and lactosylceramide BETA-galactosidases in brain, white blood cells and aminotic fluid cells.
beta-galactosidase deficiency
Chronic GM1 gangliosidosis presenting as dystonia: I. Clinical and pathological features.
beta-galactosidase deficiency
Clinical and molecular heterogeneity in hereditary beta-galactosidase deficiency.
beta-galactosidase deficiency
Combined sialidase (neuraminidase) and beta-galactosidase deficiency. Clinical, morphological and enzymological observations in a patient.
beta-galactosidase deficiency
Complementation analysis of beta-galactosidase deficiency by means of histochemical method.
beta-galactosidase deficiency
Complementation studies with enucleated fibroblasts from different variants of beta-galactosidase deficiency.
beta-galactosidase deficiency
Correction of acid beta-galactosidase deficiency in GM1 gangliosidosis human fibroblasts by retrovirus vector-mediated gene transfer: higher efficiency of release and cross-correction by the murine enzyme.
beta-galactosidase deficiency
Detection of acid-beta-galactosidase activity in viable human fibroblasts by flow cytometry.
beta-galactosidase deficiency
Development and medical application of unsaturated carbaglycosylamine glycosidase inhibitors.
beta-galactosidase deficiency
Disentangling molecular and clinical stratification patterns in beta-galactosidase deficiency.
beta-galactosidase deficiency
Effects of exogenous beta-galactosidase on cultured fibroblasts with beta-galactosidase deficiency.
beta-galactosidase deficiency
Effects of thiol protease inhibitors on intracellular degradation of exogenous beta-galactosidase in cultured human skin fibroblasts.
beta-galactosidase deficiency
Expression and characterization of 14 GLB1 mutant alleles found in GM1-gangliosidosis and Morquio B patients.
beta-galactosidase deficiency
Expression of beta-galactosidase in preimplantation ovine and porcine embryos.
beta-galactosidase deficiency
Fibroblast screening for chaperone therapy in beta-galactosidosis.
beta-galactosidase deficiency
Fine structure of meganeurites and secondary growth processes in feline GM1-gangliosidosis.
beta-galactosidase deficiency
Four novel mutations in patients from the Middle East with the infantile form of GM1-gangliosidosis.
beta-galactosidase deficiency
Ganglioside GM1 metabolism in living human fibroblasts with beta-galactosidase deficiency.
beta-galactosidase deficiency
Generalized gangliosidosis: acid beta-galactosidase deficiency with early onset, rapid mental deterioration and minimal bone dysplasia.
beta-galactosidase deficiency
GM1-ganglioside accumulation and beta-galactosidase deficiency in a case of GM1-gangliosidosis (Landing disease).
beta-galactosidase deficiency
GM1-gangliosidosis in Alaskan huskies: clinical and pathologic findings.
beta-galactosidase deficiency
Homologous modeling of the lysosomal protective protein/carboxypeptidase L: structural and functional implications of mutations identified in galactosialidosis patients.
beta-galactosidase deficiency
Immunoelectron microscopical localization of lysosomal beta-galactosidase and its precursor forms in normal and mutant human fibroblasts.
beta-galactosidase deficiency
Incorporation and degradation of GM1 ganglioside and asialoGM1 ganglioside in cultured fibroblasts from normal individuals and patients with beta-galactosidase deficiency.
beta-galactosidase deficiency
Infantile cardiomyopathy and neuromyopathy with beta-galactosidase deficiency.
beta-galactosidase deficiency
Infantile G(M1) gangliosidosis: complete morphology and histochemistry of two autopsy cases, with particular reference to delayed central nervous system myelination.
beta-galactosidase deficiency
Intergenic complementation after fusion of fibroblasts from different patients with beta-galactosidase deficiency.
beta-galactosidase deficiency
Interspecific genetic complementation analysis of human and sheep fibroblasts with beta-galactosidase deficiency.
beta-galactosidase deficiency
Intracellular processing and maturation of mutant gene products in hereditary beta-galactosidase deficiency (beta-galactosidosis).
beta-galactosidase deficiency
Km defect in neuraminidase of dysmorphic type sialidosis with and without beta-galactosidase deficiency.
beta-galactosidase deficiency
Landing disease, GM1 generalized gangliosidosis, and malabsorption syndrome.
beta-galactosidase deficiency
Localized beta-galactosidase deficiency. Occurrence in cerebellar ataxia with myoclonus epilepsy and macular cherry-red spot--a new variant of GM1-gangliosidosis?
beta-galactosidase deficiency
Lymphoblastoid cell lines, transformed by Epstein-Barr virus, in the enzymatic study of hereditary lysosomal storage diseases.
beta-galactosidase deficiency
Lysosomal enzyme activities among Chinese: leukocyte alpha-galactosidase and beta-galactosidase.
beta-galactosidase deficiency
Lysosomal sialidase deficiency in sialidosis with partial beta-galactosidase deficiency.
beta-galactosidase deficiency
Macular cherry-red spots and beta-galactosidase deficiency in an adult. An autopsy case with progressive cerebellar ataxia, myoclonus, thrombocytopathy, and accumulation of polysaccharide in liver.
beta-galactosidase deficiency
Macular cherry-red spots and myoclonus with dementia: coexistent neuraminidase and beta-galactosidase deficiencies.
beta-galactosidase deficiency
Measurement of Elevated Concentrations of Urine Keratan Sulfate by UPLC-MSMS in Lysosomal Storage Disorders (LSDs): Comparison of Urine Keratan Sulfate Levels in MPS IVA Versus Other LSDs.
beta-galactosidase deficiency
Meganeurites and other aberrant processes of neurons in feline GM1-gangliosidosis: a Golgi study.
beta-galactosidase deficiency
Molecular basis of GM1 gangliosidosis and Morquio disease, type B. Structure-function studies of lysosomal beta-galactosidase and the non-lysosomal beta-galactosidase-like protein.
beta-galactosidase deficiency
Molecular form and subcellular distribution of acid beta-galactosidase in fibroblasts from patients with GM1 gangliosidosis, Morquio B disease and galactosialidosis.
beta-galactosidase deficiency
Morphological analysis of corneal opacity in Shiba dog with GM1 gangliosidosis.
beta-galactosidase deficiency
Morquio syndrome (mucopolysaccharidosis IV B) associated with beta-galactosidase deficiency. Report of two cases.
beta-galactosidase deficiency
Morquio's disease type B (beta-galactosidase deficiency) in three siblings.
beta-galactosidase deficiency
Morquio-B disease, spondyloepiphyseal dysplasia associated with acid beta-galactosidase deficiency. Report of three cases in one family.
beta-galactosidase deficiency
Morquio-B syndrome (MPS-IV B) associated with beta-galactosidase deficiency in two siblings.
beta-galactosidase deficiency
Morquio-like syndrome with beta galactosidase deficiency and normal hexosamine sulfatase activity: mucopolysacchariodosis IVB.
beta-galactosidase deficiency
Mucolipidosis I: studies of sialidase activity and a prenatal diagnosis.
beta-galactosidase deficiency
Multiple carbohydrate-cleaving specificities in human acidic and neutral glycosidases.
beta-galactosidase deficiency
Neuraminidase deficiency and accumulation of sialic acid in lymphocytes in adult type sialidosis with partial beta-galactosidase deficiency.
beta-galactosidase deficiency
Neuraminidase in mucolipidoses: normal activity in frozen autopsy tissues from three patients with I-cell disease and adult beta-galactosidase deficiency.
beta-galactosidase deficiency
Neurochemical abnormality in I-cell disease: chemical analysis and a possible importance of beta-galactosidase deficiency.
beta-galactosidase deficiency
Neurological manifestations of knockout mice with beta-galactosidase deficiency.
beta-galactosidase deficiency
Neuronal GM1 gangliosidosis in a Siamese cat with beta-galactosidase deficiency.
beta-galactosidase deficiency
Neuronal-visceral GM1 gangliosidosis in a dog with beta-galactosidase deficiency.
beta-galactosidase deficiency
Neurovisceral and skeletal GM1-gangliosidosis in dogs with beta-galactosidase deficiency.
beta-galactosidase deficiency
Normal serum beta-galactosidase in juvenile GM1 gangliosidosis.
beta-galactosidase deficiency
Partial characterization and studies of fibroblast and leucocyte neuraminidase activities towards sialyloligosaccharides in adult sialidosis and mucolipidosis II and III.
beta-galactosidase deficiency
Pattern of beta-galactosidase deficiency in GM1-gangliosidosis type 1 and type 2.
beta-galactosidase deficiency
Prenatal diagnosis of sialidosis with combined neuraminidase and beta-galactosidase deficiency.
beta-galactosidase deficiency
Primary and secondary elastin-binding protein defect leads to impaired elastogenesis in fibroblasts from GM1-gangliosidosis patients.
beta-galactosidase deficiency
Processing of human beta-galactosidase in GM1-gangliosidosis and Morquio B syndrome.
beta-galactosidase deficiency
Spondyloepiphyseal dysplasia, corneal clouding, normal intelligence and acid beta-galactosidase deficiency.
beta-galactosidase deficiency
Substrate specificities of the two genetically distinct human brain beta-galactosidases.
beta-galactosidase deficiency
The complementation of beta-galactosidase in fused cells of mucolipidosis II with another variants of beta-galactosidase deficiency using new single cell enzyme assay.
beta-galactosidase deficiency
The genetic defect in the various types of human beta-galactosidase deficiency.
beta-galactosidase deficiency
The specificity of beta-galactosidase in the degradation of gangliosides.
beta-galactosidase deficiency
Three GM1-gangliosidoses and a variant of beta-galactosidase deficiency.
beta-galactosidase deficiency
Turnover of beta-galactosidase in fibroblasts from patients with genetically different types of beta-galactosidase deficiency.
beta-galactosidase deficiency
Twenty-one novel mutations in the GLB1 gene identified in a large group of GM1-gangliosidosis and Morquio B patients: possible common origin for the prevalent p.R59H mutation among gypsies.
beta-galactosidase deficiency
Urinary oligosaccharide screening in patients with beta-galactosidase deficiency.
beta-galactosidase deficiency
Use of active site-directed inhibitors to study in situ degradation of glycoproteins by the perfused rat liver.
beta-galactosidase deficiency
Variable clinical presentation in lysosomal storage disorders.
beta-galactosidase deficiency
[A case of adult type sialidosis with partial beta-galactosidase deficiency without myoclonus]
beta-galactosidase deficiency
[Adult mucolipidosis with beta-galactosidase deficiency: a clinical report, with studies of urinary sialic acid-rich substances (author's transl)]
beta-galactosidase deficiency
[Beta-galactosidase deficiency in the small intestine and its enzyme therapy]
beta-galactosidase deficiency
[beta-Galactosidosis (acid beta-galactosidase deficiency: GM1 gangliosidosis, Morquio B disease)]
beta-galactosidase deficiency
[Clinical, ultrastructural and biochemical study of a case of GM1 type 2 gangliosidosis]
beta-galactosidase deficiency
[Gangliosidosis GM1. Clinical, radiologic, biochemical and histological studies in two cases (author's transl)]
beta-galactosidase deficiency
[Molecular genetics of beta-galactosidase deficiency (GM1-gangliosidosis and Morquio syndrome type B)]
beta-galactosidase deficiency
[Morquio syndrome moderated by beta galactosidase deficiency. Mucopolysaccharidosis (type IV B) or oligosaccharidosis]
beta-galactosidase deficiency
[The metabolism of radiolabelled GM1-ganglioside in cultured skin fibroblasts from controls and patients with GM1-gangliosidosis]
beta-galactosidase deficiency
[Wolman disease, Fabry disease and beta-galactosidase deficiency]
beta-glucosidase deficiency
Chaperone therapy for neuronopathic lysosomal diseases: competitive inhibitors as chemical chaperones for enhancement of mutant enzyme activities.
beta-Mannosidosis
Formation of bacterial membrane ice-nucleating lipoglycoprotein complexes.
Blister
Acid hydrolases in blister fluid. II. Characterization and quantification of glycoside hydrolases.
Blood Platelet Disorders
Macular cherry-red spots and beta-galactosidase deficiency in an adult. An autopsy case with progressive cerebellar ataxia, myoclonus, thrombocytopathy, and accumulation of polysaccharide in liver.
Bone Diseases, Developmental
Generalized gangliosidosis: acid beta-galactosidase deficiency with early onset, rapid mental deterioration and minimal bone dysplasia.
Bone Diseases, Developmental
The effects of acid glycosaminoglycans on neonatal calvarian cultures--a role of keratan sulfate in Morquio syndrome?
Bone Resorption
Identification of gene pathways altered by deletion of the androgen receptor specifically in mineralizing osteoblasts and osteocytes in mice.
Bone Resorption
Impaired osteoblastogenesis potential of progenitor cells in skeletal unloading is associated with alterations in angiogenic and energy metabolism profile.
Bone Resorption
Influence of diphenylhydantoin on lysosomal enzyme release during bone resorption in vitro.
Brain Abscess
Production of specific glycosidase activities by Streptococcus intermedius strain UNS35 grown in the presence of mucin.
Brain Injuries, Traumatic
Adenovirus-mediated transfer and expression of beta-gal in injured hippocampus after traumatic brain injury in mice.
Brain Injuries, Traumatic
Increased vulnerability of NFH-LacZ transgenic mouse to traumatic brain injury-induced behavioral deficits and cortical damage.
Brain Ischemia
Gene transfer of HSP72 protects cornu ammonis 1 region of the hippocampus neurons from global ischemia: influence of Bcl-2.
Brain Ischemia
Postischemic gene transfer of midkine, a neurotrophic factor, protects against focal brain ischemia.
Brain Neoplasms
In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats.
Breast Neoplasms
A new method for determining the status of p53 in tumor cell lines of different origin.
Breast Neoplasms
Adenoviral-mediated gene therapy with Ad5CMVp53 and Ad5CMVp21 in combination with standard therapies in human breast cancer cell lines.
Breast Neoplasms
Adenovirus-mediated gene transfer to human breast tumor cells: an approach for cancer gene therapy and bone marrow purging.
Breast Neoplasms
Adenovirus-mediated tissue-targeted expression of the HSVtk gene for the treatment of breast cancer.
Breast Neoplasms
Apoptosis, autophagy, accelerated senescence and reactive oxygen in the response of human breast tumor cells to adriamycin.
Breast Neoplasms
Beta-galactosidase and alpha-mannosidase inhibit formation of multicellular nodules in breast cancer cell cultures.
Breast Neoplasms
Breast cancer selective gene expression and therapy mediated by recombinant adenoviruses containing the DF3/MUC1 promoter.
Breast Neoplasms
Correlation between extent of osteolytic damage and metastatic burden of human breast cancer metastasis in nude mice: real-time PCR quantitation.
Breast Neoplasms
Cyclin E expression and chemotherapeutic sensitivity in breast cancer cells.
Breast Neoplasms
Epidermal growth factor receptor as a genetic therapy target for carcinoma cell radiosensitization.
Breast Neoplasms
Functional identification of a BAC clone from 16q24 carrying a senescence gene SEN16 for breast cancer cells.
Breast Neoplasms
MCF-7 breast carcinoma cells overexpressing FGF-1 form vascularized, metastatic tumors in ovariectomized or tamoxifen-treated nude mice.
Breast Neoplasms
Measurement of tumor load and distribution in a model of cancer-induced osteolysis: a necessary precaution when testing novel anti-resorptive therapies.
Breast Neoplasms
p53-Dependent accelerated senescence induced by ionizing radiation in breast tumour cells.
Breast Neoplasms
Plasma Escherichia coli beta-galactosidase as a marker of tumor burden and response to experimental anti-neoplastic therapy in nude mice xenografted with lacZ transduced human tumor cells.
Breast Neoplasms
Quantitative demonstration of spontaneous metastasis by MCF-7 human breast cancer cells cotransfected with fibroblast growth factor 4 and LacZ.
Breast Neoplasms
Reporter gene assay demonstrates functional differences in estrogen receptor activity in purified breast cancer cells: a pilot study.
Breast Neoplasms
Selective isolation of transiently transfected cells from a mammalian cell population with vectors expressing a membrane anchored single-chain antibody.
Breast Neoplasms
Serum beta-N-acetylglucosaminidase, beta-D-glucosidase, alpha-D-glucosidase, beta-D-fucosidase, alpha-L-fucosidase and beta-D-galactosidase levels in acute viral hepatitis, pancreatitis, myocardial infarction and breast cancer.
Breast Neoplasms
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells.
Breast Neoplasms
Stable transgene expression in tumors and metastases after transduction with lentiviral vectors based on human immunodeficiency virus type 1.
Breast Neoplasms
The histochemistry of glycosidases in human benign and malignant breast tissue.
Breast Neoplasms
Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft models.
Bronchitis
Identification of a new membrane-associated polypeptide specified by the coronavirus infectious bronchitis virus.
Bronchopulmonary Dysplasia
Lysosomal enzymes in preterm infants with bronchopulmonary dysplasia: a potential diagnostic marker.
Burkitt Lymphoma
Suitability of Epstein-Barr virus-based episomal vectors for expression of cytokine genes in human lymphoma cells.
Carcinogenesis
Cell-free whey from milk fermented with Bifidobacterium breve C50 used to modify the colonic microflora of healthy subjects.
Carcinogenesis
[Interaction between lysosomes and cell nucleus during diethylnitrosamine-induced carcinogenesis. I. Changes in subcellular distribution of the lysosomal enzymes acid deoxyribonuclease and beta-galactosidase during acute intoxication by diethylnitrosamine]
Carcinoid Tumor
Pulmonary carcinoid tumors: enzymic discriminants, growth rate, and early age of inception.
Carcinoma
5-fluorouracil and hydroxyurea enhance adenovirus-mediated transgene expression in colon and hepatocellular carcinoma cells.
Carcinoma
Adenoviral-mediated delivery of herpes simplex virus thymidine kinase results in tumor reduction and prolonged survival in a SCID mouse model of human ovarian carcinoma.
Carcinoma
Adenovirus-mediated ribonucleotide reductase R1 gene therapy of human colon adenocarcinoma.
Carcinoma
Beta-galactosidase as a marker of HSP70 promoter induction in Dunning R3327 prostate carcinoma cells.
Carcinoma
Carbohydrate-mediated adhesion of human colon carcinoma cells to human liver sections.
Carcinoma
Dendritic cells genetically modified with an adenovirus vector encoding the cDNA for a model antigen induce protective and therapeutic antitumor immunity.
Carcinoma
Development of micrometastases: earliest events detected with bacterial lacZ gene-tagged tumor cells.
Carcinoma
Differential suppression of human cervical cancer cell growth by adenovirus delivery of p53 in vitro: arrest phase of cell cycle is dependent on cell line.
Carcinoma
Differential transfection efficiency rates of the GM-CSF gene into human renal cell carcinoma lines by lipofection.
Carcinoma
Effect of low-dose preirradiation on induction of the HSP70B-LacZ fusion gene in human cells treated with heat shock.
Carcinoma
Enhanced oncogenicity of Asian-American human papillomavirus 16 is associated with impaired E2 repression of E6/E7 oncogene transcription.
Carcinoma
Enhanced thermal stability of lysosomal beta-D-galactosidase in parenchymal cells of tumour bearing mice.
Carcinoma
Enhancing efficacy of recombinant anticancer vaccines with prime/boost regimens that use two different vectors.
Carcinoma
Envelope and long terminal repeat sequences of an infectious murine leukemia virus from a human SCLC cell line: implications for gene transfer.
Carcinoma
Epidermal growth factor receptor as a genetic therapy target for carcinoma cell radiosensitization.
Carcinoma
Evaluation of permissiveness and cytotoxic effects in equine chondrocytes, synovial cells, and stem cells in response to infection with adenovirus 5 vectors for gene delivery.
Carcinoma
Evaluation of topical gene therapy for head and neck squamous cell carcinoma in an organotypic model.
Carcinoma
Fractional laser exposure induces neutrophil infiltration (N1 phenotype) into the tumor and stimulates systemic anti-tumor immune response.
Carcinoma
Gene transfer of the vascular endothelial growth factor receptor flt-1 suppresses pulmonary metastasis associated with lung growth.
Carcinoma
Generation of an intensely potent anthracycline by a monoclonal antibody-beta-galactosidase conjugate.
Carcinoma
In vivo interleukin-2 gene therapy of established tumors with herpes simplex amplicon vectors.
Carcinoma
Increased serum alpha-L-fucosidase and beta-N-acetylglucosaminidase activities in diabetic, cirrhotic and gastric cancer patients.
Carcinoma
Induction of senescence-like state and suppression of telomerase activity through inhibition of HPV E6/E7 gene expression in cells immortalized by HPV16 DNA.
Carcinoma
Inhibition of cell-proliferation by an adenovirus vector expressing the human wild type-p53 protein.
Carcinoma
Inhibition of tumorigenicity and metastasis of human bladder cancer growing in athymic mice by interferon-beta gene therapy results partially from various antiangiogenic effects including endothelial cell apoptosis.
Carcinoma
Intracellular production of DNA enzyme by a novel single-stranded DNA expression vector.
Carcinoma
Invasiveness by lacZ transfected non-small-cell lung cancer cells into human bronchial tissues in vitro.
Carcinoma
Localization of binding sites of Ulex europaeus I, Helix pomatia and Griffonia simplicifolia I-B4 lectins and analysis of their backbone structures by several glycosidases and poly-N-acetyllactosamine-specific lectins in human breast carcinomas.
Carcinoma
MCF-7 breast carcinoma cells overexpressing FGF-1 form vascularized, metastatic tumors in ovariectomized or tamoxifen-treated nude mice.
Carcinoma
MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence.
Carcinoma
Modification to the capsid of the adenovirus vector that enhances dendritic cell infection and transgene-specific cellular immune responses.
Carcinoma
Nonviral in vivo gene delivery into tumors using a novel low volume jet-injection technology.
Carcinoma
Occurrence of antibodies to L1, L2, E4 and E7 gene products of human papillomavirus types 6b, 16 and 18 among cervical cancer patients and controls.
Carcinoma
Persistent, antigen-specific, therapeutic antitumor immunity by dendritic cells genetically modified with an adenoviral vector to express a model tumor antigen.
Carcinoma
Phospholipid- and fatty acid-composition in the erythrocyte membrane of the one-humped camel [Camelus dromedarius] and its influence on vesicle properties prepared from these lipids.
Carcinoma
Pulmonary carcinoid tumors: enzymic discriminants, growth rate, and early age of inception.
Carcinoma
Real-time polymerase chain reaction quantitation of relative expression of genes modulated by p53 using SYBR Green I.
Carcinoma
Recruitment of human umbilical vein endothelial cells and human primary fibroblasts into experimental tumors growing in SCID mice.
Carcinoma
Regional delivery and selective expression of a high-activity yeast cytosine deaminase in an intrahepatic colon cancer model.
Carcinoma
Self-immolative nitrogen mustards prodrugs cleavable by carboxypeptidase G2 (CPG2) showing large cytotoxicity differentials in GDEPT.
Carcinoma
Serum decreases the size of Metafectene-and Genejammer-DNA complexes but does not affect significantly their transfection activity in SCCVII murine squamous cell carcinoma cells.
Carcinoma
Stable transgene expression in tumors and metastases after transduction with lentiviral vectors based on human immunodeficiency virus type 1.
Carcinoma
Studies of the activities of lysosomal enzymes in serum and buccal pouch tissue of hamsters during 7,12-dimethylbenz[a]anthracene-induced carcinogenesis.
Carcinoma
Studies on variations of glycoproteins and lysosomal hydrolases in human uterine cervical carcinoma.
Carcinoma
Suicide gene therapy for human oral squamous cell carcinoma cell lines with adeno-associated virus vector.
Carcinoma
Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft models.
Carcinoma
Transduction of normal and malignant oral epithelium by an adenovirus vector: the effect of dose and treatment time on transduction efficiency and tissue penetration.
Carcinoma
Transgenic expression of 15-lipoxygenase 2 (15-LOX2) in mouse prostate leads to hyperplasia and cell senescence.
Carcinoma
Ultrasound facilitates transduction of naked plasmid DNA into colon carcinoma cells in vitro and in vivo.
Carcinoma
Wild-type p53 and p73 negatively regulate expression of proliferation related genes.
Carcinoma
[Immunohistochemical studies on non neoplastic and neoplastic gastric mucosa. Determination of embryonic and specific antigens (author's transl)]
Carcinoma
[Reporter genes transfer into human squamous cell carcinoma of larynx factor receptor mediated non-viral GE7 polypeptide delivery system with a new epidermal growth]
Carcinoma
[The mechanism of bystander effect in herpes simplex virus thymidine kinase/ganciclovir-mediated gene therapy]
Carcinoma
[Transcriptional inhibition of human papilloma virus in cervical carcinoma cells reactivates functions of the tumor suppressor p53]
Carcinoma, Bronchogenic
Highly selective glycosylated prodrugs of cytostatic CC-1065 analogues for antibody-directed enzyme tumor therapy.
Carcinoma, Ehrlich Tumor
Glycosidases of Ehrlich ascites tumor cells and ascitic fluid--purification and substrate specificity of alpha-N-acetylgalactosaminidase and alpha-galactosidase: comparison with coffee bean alpha-galactosidase.
Carcinoma, Embryonal
DNA rearrangement activity during retinoic acid-induced neural differentiation of P19 mouse embryonal carcinoma cells.
Carcinoma, Embryonal
Expression pattern of SR alpha promoter in human embryonal carcinoma and transgenic tissues in mice.
Carcinoma, Embryonal
Regulation of the mouse cellular retinoic acid-binding protein-I gene by thyroid hormone and retinoids in transgenic mouse embryos and P19 cells.
Carcinoma, Endometrioid
DNA damage detected with gammaH2AX in endometrioid adenocarcinoma cell lines.
Carcinoma, Hepatocellular
5-fluorouracil and hydroxyurea enhance adenovirus-mediated transgene expression in colon and hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
A potential approach for gene therapy targeting hepatoma using a liver-specific promoter on a retroviral vector.
Carcinoma, Hepatocellular
Adenovirus-mediated overexpression of murine cyclic nucleotide phosphodiesterase 3B.
Carcinoma, Hepatocellular
Aryl hydrocarbon receptor ligand activity of polycyclic aromatic ketones and polycyclic aromatic quinones.
Carcinoma, Hepatocellular
Cyclin-dependent kinase site-regulated signal-dependent nuclear localization of the SW15 yeast transcription factor in mammalian cells.
Carcinoma, Hepatocellular
Demonstration of the presence of protease-cutting site in the spacer of hepatitis B viral Pol protein.
Carcinoma, Hepatocellular
Development of pyrrolo[2,1-c][1,4]benzodiazepine beta-galactoside prodrugs for selective therapy of cancer by ADEPT and PMT.
Carcinoma, Hepatocellular
Effects of overexpression of the amino-terminal fragment of apolipoprotein B on apolipoprotein B and lipoprotein production.
Carcinoma, Hepatocellular
Enhanced antitumor effect of EGF R-targeted p21WAF-1 and GM-CSF gene transfer in the established murine hepatoma by peritumoral injection.
Carcinoma, Hepatocellular
Evidence for an inhibitory feedback loop regulating simian virus 40 large T-antigen fusion protein nuclear transport.
Carcinoma, Hepatocellular
Glycosidases in normal and regenerating chicken liver, hepatoma Mc-29, Rous sarcoma, in turkey poult liver and hemocytoblastomes, provoked by the leukosis virus strain Mc-31.
Carcinoma, Hepatocellular
Glycosylphosphatidylinositol-specific phospholipase d in nonalcoholic Fatty liver disease: a preliminary study.
Carcinoma, Hepatocellular
Hepatitis B virus X protein overcomes stress-induced premature senescence by repressing p16(INK4a) expression via DNA methylation.
Carcinoma, Hepatocellular
In vitro and in vivo hepatoma cell-specific expression of a gene transferred with an adenoviral vector.
Carcinoma, Hepatocellular
In vivo gene therapy for alpha-fetoprotein-producing hepatocellular carcinoma by adenovirus-mediated transfer of cytosine deaminase gene.
Carcinoma, Hepatocellular
Kinetic characterization of the human retinoblastoma protein bipartite nuclear localization sequence (NLS) in vivo and in vitro. A comparison with the SV40 large T-antigen NLS.
Carcinoma, Hepatocellular
Novel properties of the nucleolar targeting signal of human angiogenin.
Carcinoma, Hepatocellular
Nuclear transport kinetics depend on phosphorylation-site-containing sequences flanking the karyophilic signal of the Simian virus 40 T-antigen.
Carcinoma, Hepatocellular
Pseudomonas exotoxin antisense RNA selectively kills hepatitis B virus infected cells.
Carcinoma, Hepatocellular
Quantitative comparison of polyethylenimine formulations and adenoviral vectors in terms of intracellular gene delivery processes.
Carcinoma, Hepatocellular
Rapid production of interleukin-2-secreting tumor cells by herpes simplex virus-mediated gene transfer: implications for autologous vaccine production.
Carcinoma, Hepatocellular
Retroviral delivery of DNA into the livers of transgenic mice bearing premalignant and malignant hepatocellular carcinomas.
Carcinoma, Hepatocellular
Serum and host liver activities of glycosidases and sialyltransferases in animals bearing transplantable tumors.
Carcinoma, Hepatocellular
Systemic genetic transfer of p21WAF-1 and GM-CSF utilizing of a novel oligopeptide-based EGF receptor targeting polyplex.
Carcinoma, Hepatocellular
Transactivation of the early SV40 promoter by avian infectious laryngotracheitis virus in avian hepatoma cells.
Carcinoma, Hepatocellular
Two distinct modes of cell death induced by doxorubicin: apoptosis and cell death through mitotic catastrophe accompanied by senescence-like phenotype.
Carcinoma, Hepatocellular
[The influence of tumor growth on natural cytotoxicity and activity of some lysosomal enzymes of human effector cells and the C3HA mouse splenocytes]
Carcinoma, Lewis Lung
Enhanced thermal stability of lysosomal beta-D-galactosidase in parenchymal cells of tumour bearing mice.
Carcinoma, Papillary
Histochemical demonstration and analysis of poly-N-acetyllactosamine structures in normal and malignant human tissues.
Carcinoma, Papillary
Histochemical demonstration of different types of poly-N-acetyllactosamine structures in human thyroid neoplasms using lectins and endo-beta-galactosidase digestion.
Carcinoma, Papillary
Histochemical differences of the lectin affinities of backbone polylactosamine structures carrying the ABO blood group antigens in papillary carcinoma and other types of thyroid neoplasm.
Carcinoma, Papillary
Simultaneous expression of keratan sulphate epitope (a sulphated poly-N-acetyllactosamine) and blood group ABH antigens in papillary carcinomas of the human thyroid gland.
Carcinoma, Renal Cell
Differential transfection efficiency rates of the GM-CSF gene into human renal cell carcinoma lines by lipofection.
Carcinoma, Renal Cell
Replication-defective recombinant Semliki Forest virus encoding GM-CSF as a vector system for rapid and facile generation of autologous human tumor cell vaccines.
Carcinoma, Renal Cell
Suppression of metastasis formation by a recombinant single chain antibody-toxin targeted to full-length and oncogenic variant EGF receptors.
Carcinoma, Renal Cell
Systemic treatment with a recombinant erbB-2 receptor-specific tumor toxin efficiently reduces pulmonary metastases in mice injected with genetically modified carcinoma cells.
Carcinoma, Renal Cell
Trypanosoma cruzi infection does not impair major histocompatibility complex class I presentation of antigen to cytotoxic T lymphocytes.
Carcinoma, Renal Cell
Vaccination Directed against the Human Endogenous Retrovirus-K Envelope Protein Inhibits Tumor Growth in a Murine Model System.
Carcinoma, Squamous Cell
Evaluation of topical gene therapy for head and neck squamous cell carcinoma in an organotypic model.
Carcinoma, Squamous Cell
In vivo interleukin-2 gene therapy of established tumors with herpes simplex amplicon vectors.
Carcinoma, Squamous Cell
Pulmonary carcinoid tumors: enzymic discriminants, growth rate, and early age of inception.
Carcinoma, Squamous Cell
Receptor-mediated gene delivery using the Fab fragments of anti-epidermal growth factor receptor antibodies: improved immunogene approach.
Carcinoma, Squamous Cell
Serum decreases the size of Metafectene-and Genejammer-DNA complexes but does not affect significantly their transfection activity in SCCVII murine squamous cell carcinoma cells.
Carcinoma, Transitional Cell
Inhibition of tumorigenicity and metastasis of human bladder cancer growing in athymic mice by interferon-beta gene therapy results partially from various antiangiogenic effects including endothelial cell apoptosis.
Cardiomyopathies
Determinants of the cardiomyopathic phenotype in chimeric mice overexpressing cardiac Gsalpha.
Cardiomyopathies
Infantile cardiomyopathy and neuromyopathy with beta-galactosidase deficiency.
Cardiomyopathies
Inhibitory G protein overexpression provides physiologically relevant heart rate control in persistent atrial fibrillation.
Cardiomyopathies
Three novel beta-galactosidase gene mutations in Han Chinese patients with GM1 gangliosidosis are correlated with disease severity.
Cataract
Variation in glycosidase activity in soluble fractions in ICR/f rat lenses with the progression of cataract formation.
Cell Transformation, Neoplastic
Notch-induced mammary tumorigenesis does not involve the lobule-limited epithelial progenitor.
Central Nervous System Diseases
Generalized CNS disease and massive GM1-ganglioside accumulation in mice defective in lysosomal acid beta-galactosidase.
Cerebellar Ataxia
Adult type GMl-gangliosidosis: a complementation study on somatic cell hybrids.
Cerebellar Ataxia
Localized beta-galactosidase deficiency. Occurrence in cerebellar ataxia with myoclonus epilepsy and macular cherry-red spot--a new variant of GM1-gangliosidosis?
Cerebellar Ataxia
Macular cherry-red spots and beta-galactosidase deficiency in an adult. An autopsy case with progressive cerebellar ataxia, myoclonus, thrombocytopathy, and accumulation of polysaccharide in liver.
Cerebellar Ataxia
Neuraminidase in mucolipidoses: normal activity in frozen autopsy tissues from three patients with I-cell disease and adult beta-galactosidase deficiency.
Cerebral Palsy
Beta-galactosidase-deficient mouse as an animal model for GM1-gangliosidosis.
Chagas Disease
Reduction of parasitism tissue by treatment of mice chronically infected with Trypanosoma cruzi with lignano lactones.
Chagas Disease
Use of recombinant antigens for the accurate immunodiagnosis of Chagas' disease.
Chediak-Higashi Syndrome
Kinetics and mechanism of the bactericidal action of human neutrophils against Escherichia coli.
Cholangiocarcinoma
Combined cytosine deaminase expression, 5-fluorocytosine exposure, and radiotherapy increases cytotoxicity to cholangiocarcinoma cells.
Cholangitis
Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: a possible role in bile duct loss.
Cholera
A secretion expression system using promoter and signal peptide of cholera toxin B subunit gene.
Cholera
Frontal affinity chromatography-mass spectrometry assay technology for multiple stages of drug discovery: applications of a chromatographic biosensor.
Cholera
Priming immunization against cholera toxin and E. coli heat-labile toxin by a cholera toxin short peptide-beta-galactosidase hybrid synthesized in E. coli.
Chondrosarcoma
Gene therapy of chondrosarcoma using retrovirus vectors encoding the herpes simplex virus thymidine kinase gene.
Choroidal Effusions
[The role of lysosomal enzymes in the pathogenesis of ciliochoroidal detachment]
Choroidal Neovascularization
Retrovirus-mediated gene transfer to photocoagulation-induced choroidal neovascular membranes.
Cockayne Syndrome
Detection of an involvement of the human mismatch repair genes hMLH1 and hMSH2 in nucleotide excision repair is dependent on UVC fluence to cells.
Cockayne Syndrome
Enhanced host cell reactivation of a UV-damaged reporter gene in pre-UV-treated cells is delayed in Cockayne syndrome cells.
Cockayne Syndrome
Increased expression of p53 enhances transcription-coupled repair and global genomic repair of a UVC-damaged reporter gene in human cells.
Coinfection
bcl-2 expression in Spodoptera Frugiperda Sf-9 and Trichoplusia Ni BTI-Tn-5B1-4 insect cells: Effect on recombinant protein expression and cell viability.
Coinfection
Coinfection of Spodoptera exigua and Spodoptera frugiperda cell lines with the nuclear polyhedrosis viruses of Autographa californica and Spodoptera exigua.
Coinfection
Herpes simplex virus 1 (HSV-1) helper co-infection affects the distribution of an amplicon encoded protein in glia.
Coinfection
Modulation of gene expression after replication-deficient, recombinant adenovirus-mediated gene transfer by the product of a second adenovirus vector.
Coinfection
Restoration of a functional open reading frame by homologous recombination between two adenoviral vectors.
Coinfection
The E1 sequence of bovine adenovirus type 3 and complementation of human adenovirus type 5 E1A function in bovine cells.
Coinfection
The induction and kinetics of antigen-specific CD8 T cells are defined by the stage specificity and compartmentalization of the antigen in murine toxoplasmosis.
Coinfection
Transduction of primitive human hematopoietic cells with recombinant adenovirus vectors.
Colitis
Efficient gene delivery to the inflamed colon by local administration of recombinant adenoviruses with normal or modified fibre structure.
Colitis, Ulcerative
Increased transduction of human intestinal epithelial cells by adenoviral vectors in inflammatory bowel disease.
Collagen Diseases
Diagnostic value of determinations of lysosomal hydrolases in CSF of patients with neurological diseases.
Colonic Neoplasms
A new method for determining the status of p53 in tumor cell lines of different origin.
Colonic Neoplasms
Biodistribution of HuCC49DeltaCH2-beta-galactosidase in colorectal cancer xenograft model.
Colonic Neoplasms
Combined intratumoral injection of bone marrow-derived dendritic cells and systemic chemotherapy to treat pre-existing murine tumors.
Colonic Neoplasms
High-level, beta-catenin/TCF-dependent transgene expression in secondary colorectal cancer tissue.
Colonic Neoplasms
Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells.
Colonic Neoplasms
Quantitative detection of lac-Z-transfected CC531 colon carcinoma cells in an orthotopic rat liver metastasis model.
Colonic Neoplasms
Reduced host cell reactivation of oxidative DNA damage in human cells deficient in the mismatch repair gene hMSH2.
Colonic Neoplasms
Selective suicide gene therapy of colon cancer exploiting the urokinase plasminogen activator receptor promoter.
Colonic Neoplasms
Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure.
Colonic Neoplasms
Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins.
Colonic Neoplasms
The activity of serum beta-galactosidase in colon cancer patients with a history of alcohol and nicotine dependence: preliminary data.
Colonic Neoplasms
Ursodeoxycholic acid modulates histone acetylation and induces differentiation and senescence.
Colorectal Neoplasms
Chemoembolisation of rat colorectal liver metastases with drug eluting beads loaded with irinotecan or doxorubicin.
Colorectal Neoplasms
E2F-1 overexpression sensitizes colorectal cancer cells to camptothecin.
Colorectal Neoplasms
Growth inhibition of colon cancer cells by transfection of dominant-negative apoptosis signal-regulating kinase-1.
Colorectal Neoplasms
Selective suicide gene therapy of colon cancer exploiting the urokinase plasminogen activator receptor promoter.
Communicable Diseases
Mineral Analysis, In Vitro Evaluation of Alpha-Amylase, Alpha-Glucosidase, and Beta-Galactosidase Inhibition, and Antibacterial Activities of Juglans regia L. Bark Extracts.
Connective Tissue Diseases
Acid lysosomal hydrolases in systemic sclerosis and other connective tissue diseases.
Corneal Dystrophies, Hereditary
Abnormal product of corneal explants from patients with macular corneal dystrophy.
Corneal Injuries
Blockade of TGF-beta by in vivo gene transfer of a soluble TGF-beta type II receptor in the muscle inhibits corneal opacification, edema and angiogenesis.
Corneal Injuries
Deletion of the FHL2 gene attenuating neovascularization after corneal injury.
Corneal Neovascularization
Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization.
Coronary Occlusion
Enhancement of vascular formation but not improvement of ventricular function of infarcted rat hearts by a high dose of adenovirus-carried VEGF transgene.
Crohn Disease
Fecal beta-D-galactosidase production and Bifidobacteria are decreased in Crohn's disease.
Crohn Disease
Increased transduction of human intestinal epithelial cells by adenoviral vectors in inflammatory bowel disease.
Cushing Syndrome
Effects of endogenous hypercortisolism on bone mRNA and microRNA expression in humans.
Cystic Fibrosis
Activation of transgene expression by early region 4 is responsible for a high level of persistent transgene expression from adenovirus vectors in vivo.
Cystic Fibrosis
Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: toxicity study.
Cystic Fibrosis
Characterization of factors involved in modulating persistence of transgene expression from recombinant adenovirus in the mouse lung.
Cystic Fibrosis
Clusters of Cl- channels in CFTR-expressing Sf9 cells switch spontaneously between slow and fast gating modes.
Cystic Fibrosis
Cobalamin R binder as a possible model molecule for glycoprotein study in cystic fibrosis.
Cystic Fibrosis
Cystic fibrosis transmembrane conductance regulator does not affect neutrophil migration across cystic fibrosis airway epithelial monolayers.
Cystic Fibrosis
Effect of the E4 region on the persistence of transgene expression from adenovirus vectors.
Cystic Fibrosis
Efficient gene transfer into myocardium by direct injection of adenovirus vectors.
Cystic Fibrosis
Production and characterisation of monoclonal and polyclonal antibodies to different regions of the cystic fibrosis transmembrane conductance regulator (CFTR): detection of immunologically related proteins.
Cystic Fibrosis
Targeting cell-specific gene expression with an adenovirus vector containing the lacZ gene under the control of the CFTR promoter.
Cystinosis
A study of the low beta-galactosidase activity in cystinotic fibroblasts: effects of cysteamine.
Deficiency Diseases
The specificity of beta-galactosidase in the degradation of gangliosides.
Dehydration
Hypoxia reoxygenation induces premature senescence in neonatal SD rat cardiomyocytes.
Dementia
Cerebrospinal fluid beta-glucocerebrosidase activity is reduced in Dementia with Lewy Bodies.
Dementia
Macular cherry-red spots and myoclonus with dementia: coexistent neuraminidase and beta-galactosidase deficiencies.
Demyelinating Diseases
A model for long-term transgene expression in spinal cord regeneration studies.
Demyelinating Diseases
Demyelination but no cognitive, motor or behavioral deficits after adenovirus-mediated gene transfer into the brain.
Dengue
Production of the baculovirus-expressed dengue virus glycoprotein NS1 can be improved dramatically with optimised regimes for fed-batch cultures and the addition of the insect moulting hormone, 20-Hydroxyecdysone.
Dental Caries
Impairment of osteocalcin production in senescent periodontal ligament fibroblasts.
Dermatitis, Contact
Adenovirus-mediated blockade of lymphotoxin-beta inhibits the induction of contact sensitivity in mice.
Diabetes Complications
Alterations of glycosaminoglycan metabolism in the development of diabetic complications in relation to metabolic control.
Diabetes Mellitus
Alterations in the activity of several glycohydrolases in red blood cell membrane from type 2 diabetes mellitus patients.
Diabetes Mellitus
Alterations of glycosaminoglycan metabolism in the development of diabetic complications in relation to metabolic control.
Diabetes Mellitus
Association Study between BGLAP Gene HindIII Polymorphism and Type 2 Diabetes Mellitus Development in Ukrainian Population.
Diabetes Mellitus
Changes in pancreatic lysosomal enzymes activity as the potential factors leading to diabetic enteropathy.
Diabetes Mellitus
Increased serum alpha-L-fucosidase and beta-N-acetylglucosaminidase activities in diabetic, cirrhotic and gastric cancer patients.
Diabetes Mellitus
Prospective study of the enzymatic activities in urine of N-acetyl-beta-D-glucosaminidase, alpha-D-mannosidase, alpha- and beta-D-glucosidases, alpha-L- and beta-D-fucosidases, and beta-D-galactosidase in type I diabetes mellitus with early nephropathy.
Diabetes Mellitus
Urinary acidic glycohydrolases as an index of kidney damage in juvenile diabetes mellitus.
Diabetes Mellitus
[Activity of lysosomal enzymes in diabetes mellitus patients along with diffuse enlargement of the thyroid gland]
Diabetes Mellitus, Type 1
Hematopoietic stem cell transplantation prevents diabetes in NOD mice but does not contribute to significant islet cell regeneration once disease is established.
Diabetes Mellitus, Type 1
Prospective study of the enzymatic activities in urine of N-acetyl-beta-D-glucosaminidase, alpha-D-mannosidase, alpha- and beta-D-glucosidases, alpha-L- and beta-D-fucosidases, and beta-D-galactosidase in type I diabetes mellitus with early nephropathy.
Diabetes Mellitus, Type 1
Saliva of patients with Type 1 diabetes: effect of smoking on activity of lysosomal exoglycosidases.
Diabetes Mellitus, Type 2
Alterations in the activity of several glycohydrolases in red blood cell membrane from type 2 diabetes mellitus patients.
Diabetes Mellitus, Type 2
Alterations of glycosaminoglycan metabolism in the development of diabetic complications in relation to metabolic control.
Diabetes Mellitus, Type 2
Association Study between BGLAP Gene HindIII Polymorphism and Type 2 Diabetes Mellitus Development in Ukrainian Population.
Diabetic Nephropathies
Prospective study of the enzymatic activities in urine of N-acetyl-beta-D-glucosaminidase, alpha-D-mannosidase, alpha- and beta-D-glucosidases, alpha-L- and beta-D-fucosidases, and beta-D-galactosidase in type I diabetes mellitus with early nephropathy.
Diphtheria
Binding of the metalloregulatory protein DtxR to the diphtheria tox operator requires a divalent heavy metal ion and protects the palindromic sequence from DNase I digestion.
Diphtheria
Cell-specific Cre-mediated activation of the diphtheria toxin gene in pituitary tumor cells: potential for cytotoxic gene therapy.
Diphtheria
Cell-specific expression of the diphtheria toxin A-chain coding sequence induces cancer cell suicide.
Diphtheria
Diphtheria toxin promoter function in Corynebacterium diphtheriae and Escherichia coli.
Diphtheria
Genetically engineered diphtheria toxin fusion proteins carrying the hepatitis B surface antigen.
Diphtheria
Isolation and characterization of iron-independent positive dominant mutants of the diphtheria toxin repressor DtxR.
Diphtheria
Molecular cloning and DNA sequence analysis of a diphtheria tox iron-dependent regulatory element (dtxR) from Corynebacterium diphtheriae.
Diphtheria
Molecular cloning, DNA sequence analysis, and characterization of the Corynebacterium diphtheriae dtxR homolog from Brevibacterium lactofermentum.
Diphtheria
Naturally-occurring anti-thymocyte autoantibody which identifies a restricted CD4+CD8+CD3-/lo/int thymocyte subpopulation exhibits extensive polyspecificity.
DNA Repair-Deficiency Disorders
Complementation of transformed fibroblasts from patients with combined xeroderma pigmentosum-Cockayne syndrome.
Dwarfism
Morquio-B syndrome (MPS-IV B) associated with beta-galactosidase deficiency in two siblings.
Dysostoses
GM1 gangliosidosis and Morquio B disease: expression analysis of missense mutations affecting the catalytic site of acid beta-galactosidase.
Dysostoses
Morquio B patient/caregiver survey: First insight into the natural course of a rare GLB1 related condition.
Dysostoses
[Juvenile beta-galactosidase deficiency--a case with mental deterioration, dystonic movement, pyramidal symptoms, dysostosis and cherry red spot (author's transl)]
Dystonic Disorders
Elevated beta-N-acetylhexosaminidase activity in focal dystonia fibroblasts.
Ectromelia
Comparative analysis of the conserved region of the orthopoxvirus genome encoding the 36K and 12K proteins.
Ectromelia
Fine mechanisms of ectromelia virus thymidine kinase-negative mutants avirulence.
Endocarditis
Enzyme production by lactobacilli and the potential link with infective endocarditis.
Endometrial Neoplasms
The Potential Mechanism of Tiliroside-Dependent Inhibition of t-Butylhydroperoxide-Induced Oxidative Stress in Endometrial Carcinoma Cells.
Endometriosis
Glycosidases in the peritoneal fluid from infertile women with and without endometriosis.
Endotoxemia
Superoxide anion generating capacity and lysosomal enzyme activities of Kupffer cells in galactosamine induced hepatitis.
Enterocolitis, Necrotizing
Endemic necrotizing enterocolitis: lack of association with a specific infectious agent.
Enzootic Bovine Leukosis
Expression in bacteria of beta-galactosidase fusion proteins carrying antigenic determinants of the two X gene products of bovine leukemia virus.
Epilepsies, Myoclonic
Localized beta-galactosidase deficiency. Occurrence in cerebellar ataxia with myoclonus epilepsy and macular cherry-red spot--a new variant of GM1-gangliosidosis?
Epilepsy
Localized beta-galactosidase deficiency. Occurrence in cerebellar ataxia with myoclonus epilepsy and macular cherry-red spot--a new variant of GM1-gangliosidosis?
Epilepsy
Urinary excretion of N-acetyl-beta-glucosaminidase and beta-galactosidase by patients with epilepsy.
Equine Infectious Anemia
Highly efficient EIAV-mediated in utero gene transfer and expression in the major muscle groups affected by Duchenne muscular dystrophy.
Equine Infectious Anemia
Long-term transgene expression by administration of a lentivirus-based vector to the fetal circulation of immuno-competent mice.
Essential Hypertension
[Enzyme activities of beta-hexosaminidase in urine from patients with renal diseases (author's transl)]
exo-alpha-sialidase deficiency
A case of neuraminidase deficiency associated with a partial beta-galactosidase defect. Clinical, biochemical and radiological studies.
exo-alpha-sialidase deficiency
A comparative study of sialyloligosaccharides isolated from sialidosis and galactosialidosis urine.
exo-alpha-sialidase deficiency
Adult mucolipidosis with beta-galactosidase and neuraminidase deficiencies.
exo-alpha-sialidase deficiency
Adult type beta-galactosidase and neuraminidase deficiency in three siblings.
exo-alpha-sialidase deficiency
Adult type GMl-gangliosidosis: a complementation study on somatic cell hybrids.
exo-alpha-sialidase deficiency
Adult type mucolipidosis with beta-galactosidase and sialidase deficiency. Histological and biochemical studies.
exo-alpha-sialidase deficiency
beta-Galactosidase and neuraminidase deficiency associated with angiokeratoma corporis diffusum.
exo-alpha-sialidase deficiency
Biochemical comparison of the dysmorphic type with the normosomatic type of sialidosis.
exo-alpha-sialidase deficiency
Complementation, cross correction, and drug correction studies of combined beta-galactosidase neuraminidase deficiency in human fibroblasts.
exo-alpha-sialidase deficiency
Elastogenesis in cultured dermal fibroblasts from patients with lysosomal beta-galactosidase, protective protein/cathepsin A and neuraminidase-1 deficiencies.
exo-alpha-sialidase deficiency
Electrophysiological studies of myoclonus in sialidosis type 2.
exo-alpha-sialidase deficiency
Enhanced proteolytic degradation of normal beta-galactosidase in the lysosomal storage disease with combined beta-galactosidase and neuraminidase deficiency.
exo-alpha-sialidase deficiency
Galactosialidosis: molecular heterogeneity among distinct clinical phenotypes.
exo-alpha-sialidase deficiency
Human beta-galactosidase and alpha-neuraminidase deficient mucolipidosis: genetic complementation analysis of the neuraminidase deficiency.
exo-alpha-sialidase deficiency
Km defect in neuraminidase of dysmorphic type sialidosis with and without beta-galactosidase deficiency.
exo-alpha-sialidase deficiency
Lysosomal sialidase deficiency in sialidosis with partial beta-galactosidase deficiency.
exo-alpha-sialidase deficiency
Molecular defect in combined beta-galactosidase and neuraminidase deficiency in man.
exo-alpha-sialidase deficiency
Molecular heterogeneity in human beta-galactosidase and neuraminidase deficiency.
exo-alpha-sialidase deficiency
Neuraminidase deficiency and accumulation of sialic acid in lymphocytes in adult type sialidosis with partial beta-galactosidase deficiency.
exo-alpha-sialidase deficiency
Neuropathological findings of an autopsy case of adult beta-galactosidase and neuraminidase deficiency.
exo-alpha-sialidase deficiency
Turnover of beta-galactosidase in fibroblasts from patients with genetically different types of beta-galactosidase deficiency.
exo-alpha-sialidase deficiency
Ultrastructural and immunocytochemical study of skin fibroblasts from normal and sialidosis patients.
exo-alpha-sialidase deficiency
[Adult type beta-galactosidase and neuraminidase deficiency in 3 siblings]
exo-alpha-sialidase deficiency
[Skin and conjunctival biopsies in adult type beta-galactosidase neuraminidase deficiency]
Extranodal Extension
Gene therapy of metastatic cancer by in vivo retroviral gene targeting.
Eye Diseases
Antibodies reactive with an intracellular epitope of a recombinant 64 kDa thyroid and eye muscle protein in patients with thyroid autoimmunity and ophthalmopathy.
Fabry Disease
beta-Galactosidase and neuraminidase deficiency associated with angiokeratoma corporis diffusum.
Fabry Disease
Fibroblast alpha-galactosidase A activity for identification of Fabry's disease heterozygotes.
Facial Nerve Injuries
Adenoviral vector-mediated GDNF gene transfer prevents death of adult facial motoneurons.
Fanconi Anemia
Persistent low-level engraftment of rhesus peripheral blood progenitor cells transduced with the fanconi anemia C gene after conditioning with low-dose irradiation.
Fanconi Syndrome
Coordinately increased lysozymuria and lysosomal enzymuria induced by maleic acid.
Fibrosarcoma
Delayed reactivation of p53 in the progeny of cells surviving ionizing radiation.
Fibrosarcoma
Gene therapy for sarcoma utilizing adenoviral transfer of the beta-glucuronidase and bax genes and an anthracyline prodrug.
Fibrosarcoma
Gene transfer in dendritic cells, induced by oral DNA vaccination with Salmonella typhimurium, results in protective immunity against a murine fibrosarcoma.
Fibrosarcoma
In vivo marking of spontaneous or vaccine-induced fibrosarcomas in the domestic house cat, using an adenoviral vector containing a bifunctional fusion protein, GAL-TEK.
Fibrosarcoma
Isolated limb perfusion in the sarcoma-bearing rat: a novel preclinical gene delivery system.
Fibrosarcoma
Modulation of host immune responses stimulated by Salmonella vaccine carrier strains by using different promoters to drive the expression of the recombinant antigen.
Fibrosarcoma
Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence.
Fibrosarcoma
Salmonella vaccine carrier strains: effective delivery system to trigger anti-tumor immunity by oral route.
Fibrosarcoma
The defined attenuated Listeria monocytogenes delta mp12 mutant is an effective oral vaccine carrier to trigger a long-lasting immune response against a mouse fibrosarcoma.
Fibrosarcoma
Tumor-specific gene delivery mediated by a novel peptide-polyethylenimine-DNA polyplex targeting aminopeptidase N/CD13.
Fibrosarcoma
Use of L-plastin promoter to develop an adenoviral system that confers transgene expression in ovarian cancer cells but not in normal mesothelial cells.
Fluorosis, Dental
Evaluating the Association Between Dental Fluorosis and Polymorphisms in Bone Development and Mineralization Genes Among Population from a Fluoride Endemic Region of Eastern India.
Foot-and-Mouth Disease
Antigenicity of a viral peptide displayed on beta-galactosidase fusion proteins is influenced by the presence of the homologous partner protein.
Foot-and-Mouth Disease
Bacterially expressed antigenic peptide from foot-and-mouth disease virus capsid elicits variable immunologic responses in animals.
Foot-and-Mouth Disease
Beta-galactosidase enzymatic activity as a molecular probe to detect specific antibodies.
Foot-and-Mouth Disease
Biosensor characterization of antigenic site A of foot-and-mouth disease virus presented in different vector systems.
Foot-and-Mouth Disease
Comparison of immune responses against foot-and-mouth disease virus induced by fusion proteins using the swine IgG heavy chain constant region or beta-galactosidase as a carrier of immunogenic epitopes.
Foot-and-Mouth Disease
Discriminating foot-and-mouth disease virus-infected and vaccinated animals by use of beta-galactosidase allosteric biosensors.
Foot-and-Mouth Disease
Fusion proteins with multiple copies of the major antigenic determinant of foot-and-mouth disease virus protect both the natural host and laboratory animals.
Foot-and-Mouth Disease
High-titer bicistronic retroviral vectors employing foot-and-mouth disease virus internal ribosome entry site.
Foot-and-Mouth Disease
Improved mimicry of a foot-and-mouth disease virus antigenic site by a viral peptide displayed on beta-galactosidase surface.
Foot-and-Mouth Disease
Noncytopathic flavivirus replicon RNA-based system for expression and delivery of heterologous genes.
Foot-and-Mouth Disease
OmpA fusion proteins for presentation of foreign antigens on the bacterial outer membrane.
Foot-and-Mouth Disease
Recombinant fusion protein and DNA vaccines against foot and mouth disease virus infection in guinea pig and swine.
Foot-and-Mouth Disease
Successful mimicry of a complex viral antigen by multiple peptide insertions in a carrier protein.
Foot-and-Mouth Disease
The position of the heterologous domain can influence the solubility and proteolysis of beta-galactosidase fusion proteins in E. coli.
Foot-and-Mouth Disease
Uses of beta-galactosidase tag in on-line monitoring production of fusion proteins and gene expression in Escherichia coli.
Foot-and-Mouth Disease
[Recombinant plasmids containing hybrid protein genes with antigenic determinants of the foot and mouth virus]
Fowlpox
A recombinant fowlpox virus that expresses the VP2 antigen of infectious bursal disease virus induces protection against mortality caused by the virus.
Fowlpox
Active immunotherapy of cancer with a nonreplicating recombinant fowlpox virus encoding a model tumor-associated antigen.
Fowlpox
Construction of fowlpox virus vectors with intergenic insertions: expression of the beta-galactosidase gene and the measles virus fusion gene.
Fowlpox
Quantitative assessment of poxvirus promoters in fowlpox and vaccinia virus recombinants.
Friedreich Ataxia
Lysosomal enzymes in ataxia: discovery of two new cases of late onset hexosaminidase A and B deficiency (adult Sandhoff disease) in French Canadians.
Fucosidosis
Measurement of Elevated Concentrations of Urine Keratan Sulfate by UPLC-MSMS in Lysosomal Storage Disorders (LSDs): Comparison of Urine Keratan Sulfate Levels in MPS IVA Versus Other LSDs.
galactosylceramidase deficiency
Paradoxical influence of acid beta-galactosidase gene dosage on phenotype of the twitcher mouse (genetic galactosylceramidase deficiency).
Ganglion Cysts
A herpes simplex virus type 1 vector as marker for retrograde neuronal tracing: characterization of lacZ transcription and localization of labelled neuronal cells in sensory and autonomic ganglia after inoculation of the anterior segment of the eye.
Gangliosidoses
Beta-galactosidase in tissue culture derived from human skin and bone marrow. Enzyme defect in GM1 gangliosidosis.
Gangliosidoses
Complementation, cross correction, and drug correction studies of combined beta-galactosidase neuraminidase deficiency in human fibroblasts.
Gangliosidoses
Inactivation of GM1-ganglioside beta-galactosidase by a specific inhibitor: a model for ganglioside storage disease.
Gangliosidoses
Infantile G(M1) gangliosidosis: complete morphology and histochemistry of two autopsy cases, with particular reference to delayed central nervous system myelination.
Gangliosidoses
Leukocyte beta-galactosidase activity in the diagnosis of generalized GM 1 gangliosidosis.
Gangliosidoses
Mutations in the lysosomal beta-galactosidase gene that cause the adult form of GM1 gangliosidosis.
Gangliosidoses
Structure of the glycopeptide storage material in GM 1 gangliosidosis. Sequence determination with specific endo- and exoglycosidases.
Gangliosidoses
Substrate reduction reduces gangliosides in postnatal cerebrum-brainstem and cerebellum in GM1 gangliosidosis mice.
Gangliosidosis, GM1
A beta-galactosidase gene mutation identified in both Morquio B disease and infantile GM1 gangliosidosis.
Gangliosidosis, GM1
A common mutation site in the beta-galactosidase gene originates in Puerto Rico.
Gangliosidosis, GM1
A comparative study of sialyloligosaccharides isolated from sialidosis and galactosialidosis urine.
Gangliosidosis, GM1
A family with beta-galactosidase deficiency: three adults with atypical clinical patterns.
Gangliosidosis, GM1
A fluorimetric enzyme assay for the diagnosis of Morquio disease type A (MPS IV A).
Gangliosidosis, GM1
A quantitative cytochemical assay of beta-galactosidase in single cultured human skin fibroblasts.
Gangliosidosis, GM1
A simple method of lysosomal hydrolase assay in a single somatic cell and its application.
Gangliosidosis, GM1
A Single Injection of an Optimized Adeno-Associated Viral Vector into Cerebrospinal Fluid Corrects Neurological Disease in a Murine Model of GM1 Gangliosidosis.
Gangliosidosis, GM1
A spreadable, non-integrative and high copy number shuttle vector for Sulfolobus solfataricus based on the genetic element pSSVx from Sulfolobus islandicus.
Gangliosidosis, GM1
A two-year-old patient with an atypical expression of GM1-beta-galactosidase deficiency: biochemical, immunological, and cell genetic studies.
Gangliosidosis, GM1
Adrenoleukodystrophy and beta-galactosidase deficiency: patient and carrier.
Gangliosidosis, GM1
Adult GM1 gangliosidosis: clinical and biochemical studies on two patients and comparison to other patients called variant or adult GM1 gangliosidosis.
Gangliosidosis, GM1
An electrophoretic variant of beta-galactosidase with altered catalytic properties in a patient with GM1 gangliosidosis.
Gangliosidosis, GM1
Application of epithelial cells in culture to the biochemical studies of lysosomal hydrolase deficiencies.
Gangliosidosis, GM1
Atypical adult GM1 gangliosidosis: biochemical comparison with other forms of primary beta-galactosidase deficiency.
Gangliosidosis, GM1
Atypical expression of beta-galactosidase deficiency in a child with Hurler-like features but without neurological abnormalities.
Gangliosidosis, GM1
Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis.
Gangliosidosis, GM1
Beta-D-galactosidase in human urine: deficiency in generalized gangliosidosis.
Gangliosidosis, GM1
Beta-galactosidase deficiencies and novel GLB1 mutations in three Chinese patients with Morquio B disease or GM1 gangliosidosis.
Gangliosidosis, GM1
Beta-galactosidase deficiency in a Korat cat: a new form of feline GM1-gangliosidosis.
Gangliosidosis, GM1
beta-Galactosidase deficiency in an adult: a biochemical and somatic cell genetic study on a variant of GM1-gangliosidosis.
Gangliosidosis, GM1
beta-Galactosidase deficiency in juvenile and adult patients. Report of six Japanese cases and review of literature.
Gangliosidosis, GM1
Beta-galactosidase deficiency: prolonged survival in three patients following early central nervous system deterioration.
Gangliosidosis, GM1
Beta-galactosidase deficiency: studies of two patients with prolonged survival.
Gangliosidosis, GM1
beta-Galactosidase gene mutations in patients with slowly progressive GM1 gangliosidosis.
Gangliosidosis, GM1
Beta-galactosidase in tissue culture derived from human skin and bone marrow. Enzyme defect in GM1 gangliosidosis.
Gangliosidosis, GM1
Beta-galactosidase-deficient mouse as an animal model for GM1-gangliosidosis.
Gangliosidosis, GM1
Biochemical comparison of the dysmorphic type with the normosomatic type of sialidosis.
Gangliosidosis, GM1
Biochemical, immunological, and structural studies on a sphingolipid activator protein (SAP-1).
Gangliosidosis, GM1
Biosynthesis of the sulfatide/GM1 activator protein (SAP-1) in control and mutant cultured skin fibroblasts.
Gangliosidosis, GM1
Cardiac involvement in diseases characterized by beta-galactosidase deficiency.
Gangliosidosis, GM1
Carrier detection of sialidosis with partial beta-galactosidase deficiency by the assay of lysosomal sialidase in lymphocytes.
Gangliosidosis, GM1
Cerebrospinal fluid biomarkers showing neurodegeneration in dogs with GM1 gangliosidosis: possible use for assessment of a therapeutic regimen.
Gangliosidosis, GM1
Chaperone therapy for neuronopathic lysosomal diseases: competitive inhibitors as chemical chaperones for enhancement of mutant enzyme activities.
Gangliosidosis, GM1
Characterization of beta-galactosidase in leukocytes and fibroblasts of GM1 gangliosidosis heterozygotes compared to normal subjects.
Gangliosidosis, GM1
Characterization of beta-galactosidase mutations Asp332-->Asn and Arg148-->Ser, and a polymorphism, Ser532-->Gly, in a case of GM1 gangliosidosis.
Gangliosidosis, GM1
Chemical pathology of krabbe's disease. IV. Studies of galactosylceramide and lactosylceramide BETA-galactosidases in brain, white blood cells and aminotic fluid cells.
Gangliosidosis, GM1
Chronic GM1 gangliosidosis presenting as dystonia: I. Clinical and pathological features.
Gangliosidosis, GM1
Clinical and clinico-pathologic characteristics of Shiba dogs with a deficiency of lysosomal acid beta-galactosidase: a canine model of human GM1 gangliosidosis.
Gangliosidosis, GM1
Clinical and molecular heterogeneity in hereditary beta-galactosidase deficiency.
Gangliosidosis, GM1
Clinical features of adult GM1 gangliosidosis: report of three Indian patients and review of 40 cases.
Gangliosidosis, GM1
Combined sialidase (neuraminidase) and beta-galactosidase deficiency. Clinical, morphological and enzymological observations in a patient.
Gangliosidosis, GM1
Complementation analysis of beta-galactosidase deficiency by means of histochemical method.
Gangliosidosis, GM1
Complementation studies with enucleated fibroblasts from different variants of beta-galactosidase deficiency.
Gangliosidosis, GM1
Correction of accumulation of sulfate-containing compounds in cultured generalized gangliosidosis fibroblasts by beta-galactosidase.
Gangliosidosis, GM1
Correction of acid beta-galactosidase deficiency in GM1 gangliosidosis human fibroblasts by retrovirus vector-mediated gene transfer: higher efficiency of release and cross-correction by the murine enzyme.
Gangliosidosis, GM1
Detection of acid-beta-galactosidase activity in viable human fibroblasts by flow cytometry.
Gangliosidosis, GM1
Development and medical application of unsaturated carbaglycosylamine glycosidase inhibitors.
Gangliosidosis, GM1
Diagnosis of feline GM1 gangliosidosis by enzyme assay of cultured conjunctival cells.
Gangliosidosis, GM1
Diagnosis of subtypes of GM1 gangliosidosis in vitro and in vivo--using urinary oligosaccharides as substrates.
Gangliosidosis, GM1
Diagnosis of unsuspected fetal metabolic storage disease by routine placental examination.
Gangliosidosis, GM1
Disentangling molecular and clinical stratification patterns in beta-galactosidase deficiency.
Gangliosidosis, GM1
Dog GM1 gangliosidosis: characterization of the residual liver acid beta-galactosidase.
Gangliosidosis, GM1
Effect of bile salts on lactosylceramide beta-galactosidase activities in human brain, liver and cultured skin fibroblasts.
Gangliosidosis, GM1
Effects of exogenous beta-galactosidase on cultured fibroblasts with beta-galactosidase deficiency.
Gangliosidosis, GM1
Effects of thiol protease inhibitors on intracellular degradation of exogenous beta-galactosidase in cultured human skin fibroblasts.
Gangliosidosis, GM1
Expression and characterization of 14 GLB1 mutant alleles found in GM1-gangliosidosis and Morquio B patients.
Gangliosidosis, GM1
Expression of beta-galactosidase in preimplantation ovine and porcine embryos.
Gangliosidosis, GM1
Feline GM1 gangliosidosis: characterization of the residual liver acid beta-galactosidase.
Gangliosidosis, GM1
Fine structure of meganeurites and secondary growth processes in feline GM1-gangliosidosis.
Gangliosidosis, GM1
Four novel mutations in patients from the Middle East with the infantile form of GM1-gangliosidosis.
Gangliosidosis, GM1
Ganglioside GM1 metabolism in living human fibroblasts with beta-galactosidase deficiency.
Gangliosidosis, GM1
Gene transfer to human cells: transducing phage lambda plac gene expression in GMI-gangliosidosis fibroblasts.
Gangliosidosis, GM1
Generalized gangliosidosis: acid beta-galactosidase deficiency with early onset, rapid mental deterioration and minimal bone dysplasia.
Gangliosidosis, GM1
Generation and characterization of recombinant feline beta-galactosidase for preclinical enzyme replacement therapy studies in GM1 gangliosidosis.
Gangliosidosis, GM1
GM1 gangliosidosis and Morquio B disease: an update on genetic alterations and clinical findings.
Gangliosidosis, GM1
GM1 gangliosidosis and Morquio B disease: expression analysis of missense mutations affecting the catalytic site of acid beta-galactosidase.
Gangliosidosis, GM1
GM1 gangliosidosis in adults: clinical and molecular analysis of 16 Japanese patients.
Gangliosidosis, GM1
GM1-ganglioside accumulation and beta-galactosidase deficiency in a case of GM1-gangliosidosis (Landing disease).
Gangliosidosis, GM1
GM1-gangliosidosis in Alaskan huskies: clinical and pathologic findings.
Gangliosidosis, GM1
Human leukocyte and plasma beta-D-fucosidase: identity with beta-D-galactosidase.
Gangliosidosis, GM1
Hydrolysis of galactosylsphingosine and lactosylsphingosine by beta-galactosidases in human brain and cultured fibroblasts.
Gangliosidosis, GM1
Hyperphosphatasemia in early diagnosed infantile GM1 gangliosidosis presenting as transient hydrops fetalis.
Gangliosidosis, GM1
Identification of 14 novel GLB1 mutations, including five deletions, in 19 patients with GM1 gangliosidosis from South America.
Gangliosidosis, GM1
Identification of a novel pseudodeficiency allele in the GLB1 gene in a carrier of GM1 gangliosidosis.
Gangliosidosis, GM1
Immunological studies of beta galactosidase in normal human liver and in GM1 gangliosidosis.
Gangliosidosis, GM1
Incorporation and degradation of GM1 ganglioside and asialoGM1 ganglioside in cultured fibroblasts from normal individuals and patients with beta-galactosidase deficiency.
Gangliosidosis, GM1
Infantile cardiomyopathy and neuromyopathy with beta-galactosidase deficiency.
Gangliosidosis, GM1
Infantile G(M1) gangliosidosis: complete morphology and histochemistry of two autopsy cases, with particular reference to delayed central nervous system myelination.
Gangliosidosis, GM1
Inheritance of lysosomal acid beta-galactosidase activity and gangliosides in crosses of DBA/2J and knockout mice.
Gangliosidosis, GM1
Inherited lysosomal storage disease associated with deficiencies of beta-galactosidase and alpha-neuraminidase in sheep.
Gangliosidosis, GM1
Intergenic complementation after fusion of fibroblasts from different patients with beta-galactosidase deficiency.
Gangliosidosis, GM1
Interspecific genetic complementation analysis of human and sheep fibroblasts with beta-galactosidase deficiency.
Gangliosidosis, GM1
Intracellular processing and maturation of mutant gene products in hereditary beta-galactosidase deficiency (beta-galactosidosis).
Gangliosidosis, GM1
Intracerebroventricular enzyme replacement therapy with Beta-Galactosidase reverses brain pathologies due to GM1 gangliosidosis in mice.
Gangliosidosis, GM1
Isolation and characterization of major urinary oligosaccharides excreted by a patient with type 3 GM1 gangliosidosis.
Gangliosidosis, GM1
Juvenile GM1 gangliosidosis. Occurrence with absence of two beta-galactosidase components.
Gangliosidosis, GM1
Km defect in neuraminidase of dysmorphic type sialidosis with and without beta-galactosidase deficiency.
Gangliosidosis, GM1
Landing disease, GM1 generalized gangliosidosis, and malabsorption syndrome.
Gangliosidosis, GM1
Leukocyte beta-galactosidase activity in the diagnosis of bovine GM1 gangliosidosis.
Gangliosidosis, GM1
Localized beta-galactosidase deficiency. Occurrence in cerebellar ataxia with myoclonus epilepsy and macular cherry-red spot--a new variant of GM1-gangliosidosis?
Gangliosidosis, GM1
Lymphoblastoid cell lines, transformed by Epstein-Barr virus, in the enzymatic study of hereditary lysosomal storage diseases.
Gangliosidosis, GM1
Lysosomal enzyme activities among Chinese: leukocyte alpha-galactosidase and beta-galactosidase.
Gangliosidosis, GM1
Lysosomal sialidase deficiency in sialidosis with partial beta-galactosidase deficiency.
Gangliosidosis, GM1
Lysosomal storage diseases presenting as transient or persistent hydrops fetalis.
Gangliosidosis, GM1
Macular cherry-red spots and beta-galactosidase deficiency in an adult. An autopsy case with progressive cerebellar ataxia, myoclonus, thrombocytopathy, and accumulation of polysaccharide in liver.
Gangliosidosis, GM1
Magnetic resonance imaging findings and novel mutations in GM1 gangliosidosis.
Gangliosidosis, GM1
Manifestation of infantile GM1 gangliosidosis in the fetal eye. An electron microscopic study.
Gangliosidosis, GM1
Measurement of Elevated Concentrations of Urine Keratan Sulfate by UPLC-MSMS in Lysosomal Storage Disorders (LSDs): Comparison of Urine Keratan Sulfate Levels in MPS IVA Versus Other LSDs.
Gangliosidosis, GM1
Meganeurites and other aberrant processes of neurons in feline GM1-gangliosidosis: a Golgi study.
Gangliosidosis, GM1
Molecular basis of GM1 gangliosidosis and Morquio disease, type B. Structure-function studies of lysosomal beta-galactosidase and the non-lysosomal beta-galactosidase-like protein.
Gangliosidosis, GM1
Molecular consequences of the pathogenic mutation in feline GM1 gangliosidosis.
Gangliosidosis, GM1
Molecular form and subcellular distribution of acid beta-galactosidase in fibroblasts from patients with GM1 gangliosidosis, Morquio B disease and galactosialidosis.
Gangliosidosis, GM1
Morphological analysis of corneal opacity in Shiba dog with GM1 gangliosidosis.
Gangliosidosis, GM1
Morquio syndrome (mucopolysaccharidosis IV B) associated with beta-galactosidase deficiency. Report of two cases.
Gangliosidosis, GM1
Morquio's disease type B (beta-galactosidase deficiency) in three siblings.
Gangliosidosis, GM1
Morquio-B disease, spondyloepiphyseal dysplasia associated with acid beta-galactosidase deficiency. Report of three cases in one family.
Gangliosidosis, GM1
Morquio-B syndrome (MPS-IV B) associated with beta-galactosidase deficiency in two siblings.
Gangliosidosis, GM1
Morquio-like syndrome with beta galactosidase deficiency and normal hexosamine sulfatase activity: mucopolysacchariodosis IVB.
Gangliosidosis, GM1
Multiple carbohydrate-cleaving specificities in human acidic and neutral glycosidases.
Gangliosidosis, GM1
Mutation analyses in 17 patients with deficiency in acid beta-galactosidase: three novel point mutations and high correlation of mutation W273L with Morquio disease type B.
Gangliosidosis, GM1
Mutations in the lysosomal beta-galactosidase gene that cause the adult form of GM1 gangliosidosis.
Gangliosidosis, GM1
Myelination arrest demonstrated using magnetic resonance imaging in a child with type I GM1 gangliosidosis.
Gangliosidosis, GM1
N-butyldeoxygalactonojirimycin reduces neonatal brain ganglioside content in a mouse model of GM1 gangliosidosis.
Gangliosidosis, GM1
Neuraminidase deficiency and accumulation of sialic acid in lymphocytes in adult type sialidosis with partial beta-galactosidase deficiency.
Gangliosidosis, GM1
Neuraminidase in mucolipidoses: normal activity in frozen autopsy tissues from three patients with I-cell disease and adult beta-galactosidase deficiency.
Gangliosidosis, GM1
Neurochemical abnormality in I-cell disease: chemical analysis and a possible importance of beta-galactosidase deficiency.
Gangliosidosis, GM1
Neurological manifestations of knockout mice with beta-galactosidase deficiency.
Gangliosidosis, GM1
Neuronal GM1 gangliosidosis in a Siamese cat with beta-galactosidase deficiency.
Gangliosidosis, GM1
Neuronal-visceral GM1 gangliosidosis in a dog with beta-galactosidase deficiency.
Gangliosidosis, GM1
Neurovisceral and skeletal GM1-gangliosidosis in dogs with beta-galactosidase deficiency.
Gangliosidosis, GM1
Novel mutations (Asn 484 Lys, Thr 500 Ala, Gly 438 Glu) in Morquio B disease.
Gangliosidosis, GM1
Paradoxical influence of acid beta-galactosidase gene dosage on phenotype of the twitcher mouse (genetic galactosylceramidase deficiency).
Gangliosidosis, GM1
Partial characterization and studies of fibroblast and leucocyte neuraminidase activities towards sialyloligosaccharides in adult sialidosis and mucolipidosis II and III.
Gangliosidosis, GM1
Pattern of beta-galactosidase deficiency in GM1-gangliosidosis type 1 and type 2.
Gangliosidosis, GM1
Prenatal diagnosis of sialidosis with combined neuraminidase and beta-galactosidase deficiency.
Gangliosidosis, GM1
Presence of glycoproteins containing the polylactosamine structure in brain and liver of GM1 gangliosidosis patients. Comparative study between clinical types I and II, using endo-beta-galactosidase enzyme.
Gangliosidosis, GM1
Primary and secondary elastin-binding protein defect leads to impaired elastogenesis in fibroblasts from GM1-gangliosidosis patients.
Gangliosidosis, GM1
Processing of human beta-galactosidase in GM1-gangliosidosis and Morquio B syndrome.
Gangliosidosis, GM1
Processing of lysosomal beta-galactosidase. The C-terminal precursor fragment is an essential domain of the mature enzyme.
Gangliosidosis, GM1
Purification and characterization of human liver beta-galactosidase from a patient with the adult form of GM1 gangliosidosis and a normal control.
Gangliosidosis, GM1
Quantitation of the enzymically deficient cross reacting material in GM1 gangliosidoses.
Gangliosidosis, GM1
Report of an infant with GM1 gangliosidosis type I and extensive and unusual mongolian spots.
Gangliosidosis, GM1
Selective noncompetitive assimilation of bovine testicular beta-galactosidase and bovine liver beta-glucuronidase by generalized gangliosidosis fibroblasts.
Gangliosidosis, GM1
Spondyloepiphyseal dysplasia, corneal clouding, normal intelligence and acid beta-galactosidase deficiency.
Gangliosidosis, GM1
The Arg482His mutation in the beta-galactosidase gene is responsible for a high frequency of GM1 gangliosidosis carriers in a Cypriot village.
Gangliosidosis, GM1
The complementation of beta-galactosidase in fused cells of mucolipidosis II with another variants of beta-galactosidase deficiency using new single cell enzyme assay.
Gangliosidosis, GM1
The genetic defect in the various types of human beta-galactosidase deficiency.
Gangliosidosis, GM1
The role of glycosidically bound mannose in the assimilation of beta-galactosidase by generalized gangliosidosis fibroblasts.
Gangliosidosis, GM1
The role of lysosomal sialidase and beta-galactosidase in processing the complex carbohydrate chains on lysosomal enzymes and possibly other glycoproteins.
Gangliosidosis, GM1
The specificity of beta-galactosidase in the degradation of gangliosides.
Gangliosidosis, GM1
Three GM1-gangliosidoses and a variant of beta-galactosidase deficiency.
Gangliosidosis, GM1
Three novel beta-galactosidase gene mutations in Han Chinese patients with GM1 gangliosidosis are correlated with disease severity.
Gangliosidosis, GM1
Transient high-level expression of beta-galactosidase after transfection of fibroblasts from GM1 gangliosidosis patients with plasmid DNA.
Gangliosidosis, GM1
Turnover of beta-galactosidase in fibroblasts from patients with genetically different types of beta-galactosidase deficiency.
Gangliosidosis, GM1
Twenty-one novel mutations in the GLB1 gene identified in a large group of GM1-gangliosidosis and Morquio B patients: possible common origin for the prevalent p.R59H mutation among gypsies.
Gangliosidosis, GM1
Type 1 GM1 gangliosidosis with basal ganglia calcification: a case report.
Gangliosidosis, GM1
Type 2 GM1 gangliosidosis with long survival and neuronal ceroid lipofuscinosis.
Gangliosidosis, GM1
Type 3 (chronic) GM1 gangliosidosis presenting as infanto-choreo-athetotic dementia, without epilepsy, in three sisters.
Gangliosidosis, GM1
Type III (chronic) GM1-gangliosidosis. Histochemical and ultrastructural studies of rectal biopsy.
Gangliosidosis, GM1
Urinary oligosaccharide screening in patients with beta-galactosidase deficiency.
Gangliosidosis, GM1
Variability of bacterial gene-directed enzyme production in human genetically deficient cells.
Gangliosidosis, GM1
[A case of adult type sialidosis with partial beta-galactosidase deficiency without myoclonus]
Gangliosidosis, GM1
[Adult mucolipidosis with beta-galactosidase deficiency: a clinical report, with studies of urinary sialic acid-rich substances (author's transl)]
Gangliosidosis, GM1
[Beta-galactosidase deficiency in the small intestine and its enzyme therapy]
Gangliosidosis, GM1
[beta-Galactosidosis (acid beta-galactosidase deficiency: GM1 gangliosidosis, Morquio B disease)]
Gangliosidosis, GM1
[Clinical, ultrastructural and biochemical study of a case of GM1 type 2 gangliosidosis]
Gangliosidosis, GM1
[Gangliosidosis GM1. Clinical, radiologic, biochemical and histological studies in two cases (author's transl)]
Gangliosidosis, GM1
[Lysosomal beta-galactosidase properties and the molecular genetics of GM1 gangliosidosis]
Gangliosidosis, GM1
[Molecular genetics of beta-galactosidase deficiency (GM1-gangliosidosis and Morquio syndrome type B)]
Gangliosidosis, GM1
[Morquio syndrome moderated by beta galactosidase deficiency. Mucopolysaccharidosis (type IV B) or oligosaccharidosis]
Gangliosidosis, GM1
[The metabolism of radiolabelled GM1-ganglioside in cultured skin fibroblasts from controls and patients with GM1-gangliosidosis]
Gangliosidosis, GM1
[The role of ophthalmological examination in the diagnosis of gangliosidosis GM1].
Gangliosidosis, GM1
[Two siblings of type 3 GM1 gangliosidosis with different clinical features and different ages of onset]
Gastroenteritis
Comparison of enzyme-linked immunosorbent assay, electron microscopy, and reversed passive haemagglutination for detection of human rotavirus in stool specimens.
Gastroenteritis
Expression of porcine transmissible gastroenteritis virus genes in E. coli as beta-galactosidase chimaeric proteins.
Gastroenteritis, Transmissible, of Swine
Expression of porcine transmissible gastroenteritis virus genes in E. coli as beta-galactosidase chimaeric proteins.
Gaucher Disease
Identity of beta-glucosidase, beta-xylosidase and one of the beta-galactosidase activities in human liver when assayed with 4-methylumbelliferyl-beta-D-glycosides studies in cases of Gaucher's disease.
Gaucher Disease
Lymphoblastoid cell lines, transformed by Epstein-Barr virus, in the enzymatic study of hereditary lysosomal storage diseases.
Gaucher Disease
Multiple carbohydrate-cleaving specificities in human acidic and neutral glycosidases.
Genetic Diseases, Inborn
Characterization of human lysosomal neuraminidase defines the molecular basis of the metabolic storage disorder sialidosis.
Genetic Diseases, Inborn
GM1 gangliosidosis: clinical and laboratory findings in eight families.
Genetic Diseases, Inborn
Substrate specificities of the two genetically distinct human brain beta-galactosidases.
Giant Cell Tumors
Modulation of osteoclast function by adenovirus vector-induced epidermal growth factor receptor.
Glioblastoma
Adeno-associated virus (AAV) serotypes 2, 4 and 5 display similar transduction profiles and penetrate solid tumor tissue in models of human glioma.
Glioblastoma
Increased activity of lysosomal glycohydrolases in glioma tissue and surrounding areas from human brain.
Glioblastoma
Integration of active human beta-galactosidase gene (100 kb) into genome using HSV/AAV amplicon vector.
Glioblastoma
Invasive pattern of lac-Z-transfected human glioblastoma cells in nude mice brain.
Glioblastoma
Up-regulation of vascular endothelial growth factor expression in a rat glioma is conferred by two distinct hypoxia-driven mechanisms.
Glioblastoma
[Gene transduction for experimental brain tumors using recombinant adenovirus vector]
Glioma
A glycosylated nitric oxide donor, beta-Gal-NONOate, and its site-specific antitumor activity.
Glioma
Adeno-associated virus (AAV) serotypes 2, 4 and 5 display similar transduction profiles and penetrate solid tumor tissue in models of human glioma.
Glioma
Antitumor effect and cellular immunity activation by murine interferon-beta gene transfer against intracerebral glioma in mouse.
Glioma
Beta-galactosidase gene transfer to human malignant glioma in vivo using replication-deficient retroviruses and adenoviruses.
Glioma
Combined antitumor effects of an adenoviral cytosine deaminase/thymidine kinase fusion gene in rat C6 glioma.
Glioma
Efficient retrovirus-mediated cytokine-gene transduction of primary-cultured human glioma cells for tumor vaccination therapy.
Glioma
Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line.
Glioma
Gene therapy for malignant glioma using Sindbis vectors expressing a fusogenic membrane glycoprotein.
Glioma
Glypican and biglycan in the nuclei of neurons and glioma cells: presence of functional nuclear localization signals and dynamic changes in glypican during the cell cycle.
Glioma
Growth related changes in sugar determinants on the surface of C6 glioma cells in culture: a cytochemical lectin-binding study.
Glioma
Improved lipid-mediated gene transfer in C6 glioma cells and primary glial cells using FuGene.
Glioma
Inactivation of GM1-ganglioside beta-galactosidase by a specific inhibitor: a model for ganglioside storage disease.
Glioma
Intracerebral adenovirus-mediated p53 tumor suppressor gene therapy for experimental human glioma.
Glioma
Lipid-mediated gene transfer into primary neurons using FuGene: comparison to C6 glioma cells and primary glia.
Glioma
Liposome-mediated gene transfer into established CNS cell lines, primary glial cells, and in vivo.
Glioma
Repeated exposure to cationic immunoliposomes activates effective gene transfer to human glioma cells.
Glioma
Retrovirus-mediated gene transfer targeted to malignant glioma cells in murine brain.
Glioma
Selective expression of foreign genes in glioma cells: use of the mouse myelin basic protein gene promoter to direct toxic gene expression.
Glioma
Stereotactic delivery of a recombinant adenovirus into a C6 glioma cell line in a rat brain tumor model.
Glioma
The Histone Demethylase Jumonji Coordinates Cellular Senescence Including Secretion of Neural Stem Cell-attracting Cytokines.
Glioma
The lac-z reporter gene: a tool for in vitro studies of malignant glioma cell invasion.
Glioma
Transfection of a vector expressing wild-type p53 into cells of two human glioma cell lines enhances radiation toxicity.
Glioma
Transgene expression in malignant glioma using a replication-defective adenoviral vector containing the Egr-1 promoter: activation by ionizing radiation or uptake of radioactive iododeoxyuridine.
Gliosarcoma
Intratumoral activation and enhanced chemotherapeutic effect of oxazaphosphorines following cytochrome P-450 gene transfer: development of a combined chemotherapy/cancer gene therapy strategy.
Gliosarcoma
Transgene expression in malignant glioma using a replication-defective adenoviral vector containing the Egr-1 promoter: activation by ionizing radiation or uptake of radioactive iododeoxyuridine.
Gliosarcoma
[Gene transduction for experimental brain tumors using recombinant adenovirus vector]
Glomerulonephritis
Changes in lysosome populations in the rat kidney cortex induced by passive Heymann glomerulonephritis.
Glomerulonephritis
Comparison of the urinary excretion of aspartate aminotransferase, lactic dehydrogenase, alkaline and acid phosphatases and beta-galactosidase during nephrotoxic serum glomerulonephritis and mercuric chloride tubulonephritis in the rat.
Glomerulonephritis
Urinary glycosaminoglycans, sialic acid and lysosomal enzymes increase in nonalbuminuric diabetic patients.
Glycogen Storage Disease Type II
Expression of lysosomal enzymes in human mutant fibroblast-chick erythrocyte heterokaryons.
Glycogen Storage Disease Type II
Measurement of Elevated Concentrations of Urine Keratan Sulfate by UPLC-MSMS in Lysosomal Storage Disorders (LSDs): Comparison of Urine Keratan Sulfate Levels in MPS IVA Versus Other LSDs.
Glycosuria
Acid glycohydrolase in Chinese hamster with spontaneous diabetes. I. Depressed levels of renal alpha-galactosidase and beta-galactosidase.
Granuloma
Histoenzymology of the lung. II. The behaviour of lung hydrolytic enzymes during some experimental pulmonary processes.
Granuloma
The substance P receptor is necessary for a normal granulomatous response in murine schistosomiasis mansoni.
Graves Disease
Antibodies reactive with an intracellular epitope of a recombinant 64 kDa thyroid and eye muscle protein in patients with thyroid autoimmunity and ophthalmopathy.
Graves Ophthalmopathy
Antibodies reactive with an intracellular epitope of a recombinant 64 kDa thyroid and eye muscle protein in patients with thyroid autoimmunity and ophthalmopathy.
Head and Neck Neoplasms
Silk-elastinlike protein polymer hydrogels for localized adenoviral gene therapy of head and neck tumors.
Head Injuries, Penetrating
Indicator expression directed by regulatory sequences of the glial fibrillary acidic protein (GFAP) gene: in vivo comparison of distinct GFAP-lacZ transgenes.
Heart Failure
Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure.
Heart Failure
Improved exercise capacity and reduced systemic inflammation after adenoviral-mediated SERCA-2a gene transfer.
Helicobacter Infections
NF-kappaB activation during acute Helicobacter pylori infection in mice.
Hemorrhagic Fever with Renal Syndrome
Cloning and sequencing of Puumala virus Sotkamo strain S and M RNA segments: evidence for strain variation in hantaviruses and expression of the nucleocapsid protein.
Hepatitis
Adenovirus-based gene therapy during clevudine treatment of woodchucks chronically infected with woodchuck hepatitis virus.
Hepatitis
Bile ductular cell reaction with senescent hepatocytes in chronic viral hepatitis is lost during hepatocarcinogenesis.
Hepatitis
Molecular cloning of hepatitis delta virus RNA from an infected woodchuck liver: sequence, structure, and applications.
Hepatitis
Serum beta-N-acetylglucosaminidase, beta-D-glucosidase, alpha-D-glucosidase, beta-D-fucosidase, alpha-L-fucosidase and beta-D-galactosidase levels in acute viral hepatitis, pancreatitis, myocardial infarction and breast cancer.
Hepatitis A
Characterization of hepatitis A virus capsid proteins with antisera raised to recombinant antigens.
Hepatitis A
Membrane permeability induced by hepatitis A virus proteins 2B and 2BC and proteolytic processing of HAV 2BC.
Hepatitis B
Construction and application of plasmids containing bidirectional promoters of vaccinia virus.
Hepatitis B
Direct gene transfer to the liver with herpes simplex virus type 1 vectors: transient production of physiologically relevant levels of circulating factor IX.
Hepatitis B
Dominant negative mutants of the duck hepatitis B virus core protein interfere with RNA pregenome packaging and viral DNA synthesis.
Hepatitis B
Effect of the N-terminal hydrophobic sequence of hepatitis B virus surface antigen on the folding and assembly of hybrid beta-galactosidase in Escherichia coli.
Hepatitis B
Efficient in vivo transduction of the neonatal mouse liver with pseudotyped retroviral vectors.
Hepatitis B
Evaluation of recombinant sporozoite antigen SPAG-1 as a vaccine candidate against Theileria annulata by the use of different delivery systems.
Hepatitis B
Genetically engineered diphtheria toxin fusion proteins carrying the hepatitis B surface antigen.
Hepatitis B
Hepatitis B virus X protein overcomes stress-induced premature senescence by repressing p16(INK4a) expression via DNA methylation.
Hepatitis B
Protein folding in the cytoplasm of Escherichia coli: requirements for the DnaK-DnaJ-GrpE and GroEL-GroES molecular chaperone machines.
Hepatitis B
Protein Kinase Activity of the Insulin Receptor Is Essential for Insulin-Regulated Gene Expression.
Hepatitis B
Pseudomonas exotoxin antisense RNA selectively kills hepatitis B virus infected cells.
Hepatitis B
Selection of recombinant vaccinia viruses (Tian Tan strain) expressing hepatitis B virus surface antigen by using beta-galactosidase as a marker.
Hepatitis B
The HBV HBX gene expressed in E. coli is recognised by sera from hepatitis patients.
Hepatitis B
Use of a hybrid vaccinia virus-T7 RNA polymerase system for expression of target genes.
Hepatitis B
Use of the hemagglutinating virus of Japan (HVJ)-liposome method for analysis of infiltrating lymphocytes induced by hepatitis B virus gene expression in liver tissue.
Hepatitis B
[Construction and properties of a hybrid operon coding the HBcAG and beta-galactosidase of the hepatitis B virus in Escherichia coli]
Hepatitis C
Effect of interferon alpha and cell cycle progression on translation mediated by the hepatitis C virus 5' untranslated region: a study using a transgenic mouse model.
Hepatitis C
Noncytopathic flavivirus replicon RNA-based system for expression and delivery of heterologous genes.
Hepatitis C
The hepatitis C virus internal ribosome entry site facilitates efficient protein synthesis in blood vessel endothelium during tumour angiogenesis.
Hepatitis C
[Immune responses of a recombined live Salmonella typhimurium SL3261 expressing a multi-epitope antigen of HCV]
Hepatitis, Chronic
Detection by western blotting of an antibody to the hepatitis C virus E1 envelope protein in sera of patients with chronic liver disease.
Hepatoblastoma
Gene transfer of pigment epithelium-derived factor suppresses tumor growth and angiogenesis in a hepatoblastoma xenograft model.
Herpes Simplex
A bi-functional reporter plasmid for the simultaneous transient expression assay of two herpes simplex virus promoters.
Herpes Simplex
A herpes simplex virus mutant in which glycoprotein D sequences are replaced by beta-galactosidase sequences binds to but is unable to penetrate into cells.
Herpes Simplex
A herpes simplex virus-1 vector containing the rat tyrosine hydroxylase promoter directs cell type-specific expression of beta-galactosidase in cultured rat peripheral neurons.
Herpes Simplex
A live non-neurovirulent herpes simplex virus vector expresses beta-galactosidase in the nervous system of the Wistar and Sprague-Dawley strain rat for a prolonged period.
Herpes Simplex
Adenoviral infection of thyroid cells: a rationale for gene therapy for metastatic thyroid carcinoma.
Herpes Simplex
Adenoviral-mediated delivery of herpes simplex virus thymidine kinase results in tumor reduction and prolonged survival in a SCID mouse model of human ovarian carcinoma.
Herpes Simplex
Adenovirus-mediated gene therapy for experimental spinal cord tumors: tumoricidal efficacy and functional outcome.
Herpes Simplex
Adenovirus-mediated tissue-targeted expression of the HSVtk gene for the treatment of breast cancer.
Herpes Simplex
An efficient deletion mutant packaging system for defective herpes simplex virus vectors: potential applications to human gene therapy and neuronal physiology.
Herpes Simplex
Analysis of a multi-mutant herpes simplex virus type 1 for gene transfer into sympathetic preganglionic neurons and a comparison to adenovirus vectors.
Herpes Simplex
Antiviral susceptibility testing with a cell line which expresses beta-galactosidase after infection with herpes simplex virus.
Herpes Simplex
beta-Gal enzyme activity driven by the HSV LAT promoter does not correspond to beta-gal RNA levels in mouse trigeminal ganglia.
Herpes Simplex
Beta-galactosidase as a marker in the peripheral and neural tissues of the herpes simplex virus-infected mouse.
Herpes Simplex
Breast cancer selective gene expression and therapy mediated by recombinant adenoviruses containing the DF3/MUC1 promoter.
Herpes Simplex
Confirmation of low-titer, herpes simplex virus-positive specimen results by the enzyme-linked virus-inducible system (ELVIS) using PCR and repeat testing.
Herpes Simplex
Delivery of a foreign gene to sympathetic preganglionic neurons using recombinant herpes simplex virus.
Herpes Simplex
Differential transfection efficiency rates of the GM-CSF gene into human renal cell carcinoma lines by lipofection.
Herpes Simplex
Direct gene transfer to the liver with herpes simplex virus type 1 vectors: transient production of physiologically relevant levels of circulating factor IX.
Herpes Simplex
Effect of genomic location on expression of beta-galactosidase mRNA controlled by the herpes simplex virus type 1 UL38 promoter.
Herpes Simplex
Effect of immunity on gene delivery into anterior horn motor neurons by live attenuated herpes simplex virus vector.
Herpes Simplex
Effect of trichostatin a and 5'-azacytidine on transgene reactivation in U937 transduced cells.
Herpes Simplex
Effects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survival.
Herpes Simplex
Enhancement of neuronal protection from oxidative stress by glutamic acid decarboxylase delivery with a defective herpes simplex virus vector.
Herpes Simplex
Evaluation of a genetically engineered cell line and a histochemical beta-galactosidase assay to detect herpes simplex virus in clinical specimens.
Herpes Simplex
Expression of beta-galactosidase in neurons of dorsal root ganglia which are latently infected with herpes simplex virus type 1.
Herpes Simplex
Expression of the calcium-binding protein, parvalbumin, in cultured cortical neurons using a HSV-1 vector system enhances NMDA neurotoxicity.
Herpes Simplex
Expression of the herpes simplex virus type 1 glycoprotein C gene requires sequences in the 5' noncoding region of the gene.
Herpes Simplex
Functional expression of exogenous proteins in mammalian sensory hair cells infected with adenoviral vectors.
Herpes Simplex
Gene therapy for mice sarcoma with oncolytic herpes simplex virus-1 lacking the apoptosis-inhibiting gene, icp34.5.
Herpes Simplex
Gene therapy of chondrosarcoma using retrovirus vectors encoding the herpes simplex virus thymidine kinase gene.
Herpes Simplex
Gene therapy utilizing the Cre/loxP system selectively suppresses tumor growth of disseminated carcinoembryonic antigen-producing cancer cells.
Herpes Simplex
Gene transfer by viral vectors into blood vessels in a rat model of retinopathy of prematurity.
Herpes Simplex
Gene transfer in bovine blastocysts using replication-defective retroviral vectors packaged with Gibbon ape leukemia virus envelopes.
Herpes Simplex
Gene transfer into enteric neurons of the rat small intestine in organ culture using a replication defective recombinant herpes simplex virus type 1 (HSV1) vector, but not recombinant adenovirus vectors.
Herpes Simplex
Gene transfer into sympathetic preganglionic neurons in vivo using a non-replicating thymidine kinase-deficient herpes simplex virus type 1.
Herpes Simplex
Gene transfer into the mammalian inner ear using HSV-1 and vaccinia virus vectors.
Herpes Simplex
Generation of recombinant herpes simplex virus type 1 to be used for automatic tract tracing.
Herpes Simplex
Herpes simplex type1:lacZ recombinant viruses. II. Microtiter plate-based colorimetric assays for the discovery of new antiherpes agents and the points at which such agents disrupt the viral replication cycle.
Herpes Simplex
Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency.
Herpes Simplex
Immunogenicity in mice of tandem repeats of an epitope from herpes simplex gD protein when expressed by recombinant adenovirus vectors.
Herpes Simplex
Immunological properties of an N-terminal fragment of herpes simplex virus type 1 glycoprotein D expressed in Escherichia coli.
Herpes Simplex
Immunomodulation by topical particle-mediated administration of cytokine plasmid DNA suppresses herpetic stromal keratitis without impairment of antiviral defense.
Herpes Simplex
In vivo adenovirus-mediated suicide gene therapy of orthotopic bladder cancer.
Herpes Simplex
In vivo demethylation of a MoMuLV retroviral vector expressing the herpes simplex thymidine kinase suicide gene by 5' azacytidine.
Herpes Simplex
In vivo gene transfer to the brain cortex using a single injection of HSV-1 vector into the medial septum.
Herpes Simplex
Inactivation of the shutoff gene (UL41) of herpes simplex virus types 1 and 2.
Herpes Simplex
Infection of cultured central nervous system neurons with a defective herpes simplex virus 1 vector results in stable expression of Escherichia coli beta-galactosidase.
Herpes Simplex
Influence of the helper virus on expression of beta-galactosidase from a defective HSV-1 vector, pHSVlac.
Herpes Simplex
Long-term expression in sensory neurons in tissue culture from herpes simplex virus type 1 (HSV-1) promoters in an HSV-1-derived vector.
Herpes Simplex
Long-term gene expression in the anterior horn motor neurons after intramuscular inoculation of a live herpes simplex virus vector.
Herpes Simplex
Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing.
Herpes Simplex
Multiple vectors effectively achieve gene transfer in a murine cardiac transplantation model. Immunosuppression with TGF-beta 1 or vIL-10.
Herpes Simplex
Muscle derived cell mediated ex vivo gene transfer to the lower urinary tract: comparison of viral vectors.
Herpes Simplex
Neurons differentially control expression of a herpes simplex virus type 1 immediate-early promoter in transgenic mice.
Herpes Simplex
Nuclear egress and envelopment of herpes simplex virus capsids analyzed with dual-color fluorescence HSV1(17+).
Herpes Simplex
Preferential gene transfer to BBN-induced rat bladder tumor by simple instillation of adenoviral vector.
Herpes Simplex
Purified herpes simplex thymidine kinase Retrovector particles. I. In vitro characterization, in situ transduction efficiency, and histopathological analyses of gene therapy-treated brain tumors.
Herpes Simplex
Rapid and stable gene expression in hippocampal slice cultures from a defective HSV-1 vector.
Herpes Simplex
Rapid production of interleukin-2-secreting tumor cells by herpes simplex virus-mediated gene transfer: implications for autologous vaccine production.
Herpes Simplex
Removal of N-linked carbohydrates decreases the infectivity of herpes simplex virus type 1.
Herpes Simplex
Retroviral transfer of herpes simplex virus-thymidine kinase and beta-galactosidase genes into U937 cells with bicistronic vector.
Herpes Simplex
Retroviral vector-mediated gene transfer into keratocytes in vitro and in vivo.
Herpes Simplex
Serum decreases the size of Metafectene-and Genejammer-DNA complexes but does not affect significantly their transfection activity in SCCVII murine squamous cell carcinoma cells.
Herpes Simplex
Solid tissues can be manipulated ex vivo and used as vehicles for gene therapy.
Herpes Simplex
Studies on in vivo gene transfer in pituitary tumors using herpes-derived and adenoviral vectors.
Herpes Simplex
Suppression of tumor growth and pulmonary metastasis in murine osteosarcoma using gene therapy.
Herpes Simplex
Targeted killing of carcinoembryonic antigen (CEA)-producing cholangiocarcinoma cells by polyamidoamine dendrimer-mediated transfer of an Epstein-Barr virus (EBV)-based plasmid vector carrying the CEA promoter.
Herpes Simplex
Targeting and gene expression in spinal cord motor neurons following intramuscular inoculation of an HSV-1 vector.
Herpes Simplex
Targeting strategy for gene delivery to carcinoembryonic antigen-producing cancer cells by retrovirus displaying a single-chain variable fragment antibody.
Herpes Simplex
Th1-associated immune responses to beta-galactosidase expressed by a replication-defective herpes simplex virus.
Herpes Simplex
The gene downstream of the gC homologue in feline herpes virus type 1 is involved in the expression of virulence.
Herpes Simplex
The gene encoding the late nonstructural 36K protein of vaccinia virus is essential for virus reproduction.
Herpes Simplex
The use of beta-galactosidase as a marker gene to define the regulatory sequences of the herpes simplex virus type 1 glycoprotein C gene in recombinant herpesviruses.
Herpes Simplex
Transcriptional targeting to anterior pituitary lactotrophic cells using recombinant adenovirus vectors in vitro and in vivo in normal and estrogen/sulpiride-induced hyperplastic anterior pituitaries.
Herpes Simplex
Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta-cells from cytokine-induced destruction.
Herpes Simplex
Transgenic indicator mice for studying activated retinoic acid receptors during development.
Herpes Simplex
Use of recombinant vectors derived from herpes simplex virus 1 mutant tsK for short-term expression of transgenes encoding cytoplasmic and membrane anchored proteins in postmitotic polarized cortical neurons and glial cells in vitro.
Herpes Simplex
[Gene therapy of a model of glioblastoma in rats using adenovirus vector encoding the HSVtk gene]
Herpes Simplex
[Gene therapy of cerebral glioblastoma by adenovirus vector. Experimental model in the rat]
Herpes Simplex
[Molecular biological study of the vaccinia virus genome. IV. The late nonstructural 36K protein of vaccinia virus is vitally important]
Herpes Zoster
Characterization of the acidic N-linked glycans of the zona pellucida of prepuberal pigs by a mass spectrometric approach.
Herpes Zoster
Comparative assay of varicella skin test antigens by the ELISA and RPHA tests.
Herpes Zoster
Disulfide formation in bovine zona pellucida glycoproteins during fertilization: evidence for the involvement of cystine cross-linkages in hardening of the zona pellucida.
Herpes Zoster
Further fractionation of the glycoprotein families of porcine zona pellucida by anion-exchange HPLC and some characterization of the separated fractions.
Herpes Zoster
Histology of ovaries of female rabbits immunized with deglycosylated zona pellucida macromolecules of pigs.
Herpes Zoster
Identification of an N-glycosylated region of pig zona pellucida glycoprotein ZPB that is involved in sperm binding.
Herpes Zoster
Involvement of N-linked carbohydrate chains of pig zona pellucida in sperm-egg binding.
Herpes Zoster
Molecular cloning of bovine zona pellucida glycoproteins ZPA and ZPB and analysis for sperm-binding component of the zona.
Herpes Zoster
Sleep deprivation increases the activation of nuclear factor kappa B in lateral hypothalamic cells.
Herpes Zoster
Structural characterization of the Mr = 55,000 antigen (ZP3) of porcine oocyte zona pellucida. Purification and characterization of alpha- and beta-glycoproteins following digestion of lactosaminoglycan with endo-beta-galactosidase.
Herpes Zoster
Variegated expression of a mouse steroid 21-hydroxylase/beta- galactosidase transgene suggests centripetal migration of adrenocortical cells.
Histoplasmosis
Molecular cloning and characterization of a recombinant Histoplasma capsulatum antigen for antibody-based diagnosis of human histoplasmosis.
HIV Infections
A computer-based, image-analysis method to quantify HIV-1 infection in a single-cycle infectious center assay.
HIV Infections
Activity of lysosomal exoglycosidases in saliva of patients with HIV infection.
HIV Infections
Soluble HIV-1 gp120 enhances HIV-1 replication in non-dividing CD4+ T cells, mediated via cell signaling and Tat cofactor overexpression.
HIV Infections
Ultrasensitive and more specific enzyme immunoassay (immune complex transfer enzyme immunoassay) for p24 antigen of HIV-1 in serum using affinity-purified rabbit anti-p24 Fab' and monoclonal mouse anti-p24 Fab'.
Hydrothorax
Targeting the respiratory muscles of fetal sheep for prenatal gene therapy for Duchenne muscular dystrophy.
Hypercalcemia
Parathyroid Hormone-Related Peptide-Linked Hypercalcemia in a Melanoma Patient Treated With Ipilimumab: Hormone Source and Clinical and Metabolic Correlates.
Hyperglycemia
Acid glycohydrolase in Chinese hamster with spontaneous diabetes. I. Depressed levels of renal alpha-galactosidase and beta-galactosidase.
Hyperglycemia
Interleukin-1 receptor antagonist enhances islet engraftment without impacting serum levels of nitrite or osteopontin.
Hyperglycemia
Stress-induced responses of human skin fibroblasts in vitro reflect human longevity.
Hyperlipidemias
Hepatic insig-1 or -2 overexpression reduces lipogenesis in obese Zucker diabetic fatty rats and in fasted/refed normal rats.
Hyperlipoproteinemia Type II
Partial apolipoprotein E-beta-galactosidase fusion protein expressed in Escherichia coli retains binding activity to the LDL(B/E) receptor.
Hypersensitivity
A delayed-type hypersensitivity-inducing T-cell epitope of Semliki Forest virus mediates effective T-helper activity for antibody production.
Hypersensitivity
An upstream, DNase I hypersensitive region of the hematopoietic-expressed transcription factor GATA-1 gene confers developmental specificity in transgenic mice.
Hypersensitivity
Gene gun immunization with clinically relevant allergens aggravates allergen induced pathology and is contraindicated for allergen immunotherapy.
Hypersensitivity
Induction of a cellular immune response to a foreign antigen by a recombinant Listeria monocytogenes vaccine.
Hypersensitivity
Oral immunization with recombinant BCG induces cellular and humoral immune responses against the foreign antigen.
Hypersensitivity
Spontaneous induction of immunoregulation by an endogenous retinal antigen.
Hypersensitivity
Uptake and presentation of exogenous antigen and presentation of endogenously produced antigen by skin dendritic cells represent equivalent pathways for the priming of cellular immune responses following biolistic DNA immunization.
Hypersensitivity, Delayed
Histoenzymology of the lung. II. The behaviour of lung hydrolytic enzymes during some experimental pulmonary processes.
Hypertension
Evaluation of urinary enzyme patterns in patients with kidney diseases and primary benign hypertension.
Hypertension
Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia.
Hyperthyroidism
Antibodies reactive with an intracellular epitope of a recombinant 64 kDa thyroid and eye muscle protein in patients with thyroid autoimmunity and ophthalmopathy.
Hypothyroidism
Hormonal control of postnatal development of ileal neuraminidase and acid beta-galactosidase.
Ichthyosis
Arylsulphatase C activity in leukocytes of patients and carriers of X-linked ichthyosis.
Idiopathic Interstitial Pneumonias
BALF N-acetylglucosaminidase and beta-galactosidase activities in idiopathic pulmonary fibrosis.
Idiopathic Pulmonary Fibrosis
BALF N-acetylglucosaminidase and beta-galactosidase activities in idiopathic pulmonary fibrosis.
Infarction, Middle Cerebral Artery
Postischemic gene transfer of soluble Flt-1 protects against brain ischemia with marked attenuation of blood-brain barrier permeability.
Infections
A comparative study of higher primate foamy viruses, including a new virus from a gorilla.
Infections
A defective HSV-1 vector expresses Escherichia coli beta-galactosidase in cultured peripheral neurons.
Infections
A gene delivery/recall system for neurons which utilizes ribonucleotide reductase-negative herpes simplex viruses.
Infections
A herpes simplex virus-1 vector containing the rat tyrosine hydroxylase promoter directs cell type-specific expression of beta-galactosidase in cultured rat peripheral neurons.
Infections
A histone deacetylase inhibitor enhances adenoviral infection of renal cancer cells.
Infections
A hybrid herpesvirus infectious vector based on Epstein-Barr virus and herpes simplex virus type 1 for gene transfer into human cells in vitro and in vivo.
Infections
A new retroviral vector, CA1, to identify and select for cells expressing an inserted gene in vitro and in vivo.
Infections
A phi 80 function inhibitory for growth of lambdoid phage in him mutants of Escherichia coli deficient in integration host factor. II. Physiological analysis of the abortive infection.
Infections
A rapid method for detection of mutations in the lacI gene using PCR-single strand conformation polymorphism analysis: demonstration of its high sensitivity.
Infections
A simple and efficient procedure for the oral inoculation of Trichoplusia ni larvae with polyhedrin-negative recombinant baculovirus.
Infections
A transgenic mouse with beta-Galactosidase as a fetal liver self-antigen for immunotherapy studies.
Infections
Abortive infection in HeLaCD4 cells by a primary HIV type 1 isolate: implications for differential host cell tropism.
Infections
Activation of a beta-galactosidase recombinant provirus: application to titration of human immunodeficiency virus (HIV) and HIV-infected cells.
Infections
Adenoviral gene transfer into osteoarthritis synovial cells using the endogenous inhibitor IkappaBalpha reveals that most, but not all, inflammatory and destructive mediators are NFkappaB dependent.
Infections
Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent.
Infections
Adenoviral infection of thyroid cells: a rationale for gene therapy for metastatic thyroid carcinoma.
Infections
Adenoviral transduction of human 'clinical grade' immature dendritic cells enhances costimulatory molecule expression and T-cell stimulatory capacity.
Infections
Adenoviral transfection of isolated pancreatic islets: a study of programmed cell death (apoptosis) and islet function.
Infections
Adenoviral vector-mediated gene transfer and neurotransplantation: possibilities and limitations in grafting of the fetal rat suprachiasmatic nucleus.
Infections
Adenoviral-mediated p53 transgene expression sensitizes both wild-type and null p53 prostate cancer cells in vitro to radiation.
Infections
Adenovirus transduction to effect CD40 signalling improves the immune stimulatory activity of myeloma cells.
Infections
Adenovirus type 5 viral particles pseudotyped with mutagenized fiber proteins show diminished infectivity of coxsackie B-adenovirus receptor-bearing cells.
Infections
Adenovirus vectors differentially modulate proliferation of pituitary lactotrophs in primary culture in a mitogen and infection time-dependent manner.
Infections
Adenovirus-based gene therapy during clevudine treatment of woodchucks chronically infected with woodchuck hepatitis virus.
Infections
Adenovirus-mediated E2F-1 gene transfer efficiently induces apoptosis in melanoma cells.
Infections
Adenovirus-mediated E2F-1 gene transfer inhibits MDM2 expression and efficiently induces apoptosis in MDM2-overexpressing tumor cells.
Infections
Adenovirus-mediated E2F-1 gene transfer sensitizes melanoma cells to apoptosis induced by topoisomerase II inhibitors.
Infections
Adenovirus-mediated expression of interleukin-1 receptor antagonist in swine cells in vitro and in vivo.
Infections
Adenovirus-mediated gene expression in isolated rat pancreatic acini and individual pancreatic acinar cells.
Infections
Adenovirus-mediated gene transfer in the transplant setting. II. Successful expression of transferred cDNA in syngeneic liver grafts.
Infections
Adenovirus-mediated gene transfer into dissociated and explant cultures of rat hippocampal neurons.
Infections
Adenovirus-mediated gene transfer to human breast tumor cells: an approach for cancer gene therapy and bone marrow purging.
Infections
Adenovirus-mediated gene transfer to liver grafts: an improved method to maximize infectivity.
Infections
Adenovirus-mediated overexpression of human transforming growth factor-beta 1 in rat cardiac fibroblasts, myocytes and smooth muscle cells.
Infections
Adenovirus-mediated transfer of a dominant-negative H-ras suppresses neointimal formation in balloon-injured arteries in vivo.
Infections
Adenovirus-mediated transfer of a recombinant human alpha 1-antitrypsin cDNA to human endothelial cells.
Infections
Adenovirus-mediated transfer of CCAAT/enhancer-binding protein-alpha identifies a dominant antiproliferative role for this isoform in hepatocytes.
Infections
Adenovirus-mediated transfer of human lipase complementary DNA to the gallbladder.
Infections
Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer [seecomments]
Infections
Age-dependent effects of repeated immunization with a first generation adenovirus vector on the immune response and transgene expression in young and old rats.
Infections
Aldolase C/zebrin II expression in the neonatal rat forebrain reveals cellular heterogeneity within the subventricular zone and early astrocyte differentiation.
Infections
An equine herpesvirus 1 mutant with a lacZ insertion between open reading frames 62 and 63 is replication competent and causes disease in the murine respiratory model.
Infections
Analysis of a multi-mutant herpes simplex virus type 1 for gene transfer into sympathetic preganglionic neurons and a comparison to adenovirus vectors.
Infections
Analysis of the Mycobacterium bovis hsp60 promoter activity in recombinant Mycobacterium avium.
Infections
Analysis of the shotgun expression library of the Mycobacterium tuberculosis genome for immunodominant polypeptides: potential use in serodiagnosis.
Infections
Antibody response to recombinant lambda gt11 fusion proteins in cytomegalovirus infection.
Infections
Antigen expression by dendritic cells correlates with the therapeutic effectiveness of a model recombinant poxvirus tumor vaccine.
Infections
Antigens targeted to the Leishmania phagolysosome are processed for CD4+ T cell recognition.
Infections
Antihyperalgesic effects of infection with a preproenkephalin-encoding herpes virus.
Infections
Antiviral susceptibility testing with a cell line which expresses beta-galactosidase after infection with herpes simplex virus.
Infections
Apoptosis Signal-Regulating Kinase 1 Mediates Cellular Senescence Induced by High Glucose in Endothelial Cells.
Infections
Appearance of protease activities coincides with p10 and polyhedrin-driven protein production in the baculovirus expression system: effects on yield.
Infections
bcl-2 expression in Spodoptera Frugiperda Sf-9 and Trichoplusia Ni BTI-Tn-5B1-4 insect cells: Effect on recombinant protein expression and cell viability.
Infections
Beta galactosidase release as an alternative to chromium release in cytotoxic T-cell assays.
Infections
Beta-adrenoceptor blockade markedly attenuates transgene expression from cytomegalovirus promoters within the cardiovascular system.
Infections
Bioreactor studies on temperature induction of the Q- mutant of bacteriophage lambda in Escherichia coli.
Infections
Carcinoma induction following direct in situ transfer of v-Ha-ras into rat mammary epithelial cells using replication-defective retrovirus vectors.
Infections
Caspase activation and changes in Bcl-2 family member protein expression associated with E2F-1-mediated apoptosis in human esophageal cancer cells.
Infections
Cell cycle arrest by human cytomegalovirus 86-kDa IE2 protein resembles premature senescence.
Infections
Cell-specific induction of sensitivity to ganciclovir in medullary thyroid carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase.
Infections
Characterization of gene expression in recombinant Escherichia coli cells infected with phage lambda.
Infections
Characterization of the Streptococcus pneumoniae BgaC protein as a novel surface beta-galactosidase with specific hydrolysis activity for the Galbeta1-3GlcNAc moiety of oligosaccharides.
Infections
Clusters of Cl- channels in CFTR-expressing Sf9 cells switch spontaneously between slow and fast gating modes.
Infections
Colicin Ib does not cause plasmid-promoted abortive phage infection of Escherichia coli K-12.
Infections
Combined cytosine deaminase expression, 5-fluorocytosine exposure, and radiotherapy increases cytotoxicity to cholangiocarcinoma cells.
Infections
Comprehensive mapping of receptor-functioning domains in feline leukemia virus subgroup C receptor FLVCR1.
Infections
Confirmation of low-titer, herpes simplex virus-positive specimen results by the enzyme-linked virus-inducible system (ELVIS) using PCR and repeat testing.
Infections
Construction and characterization of herpes simplex virus type 1 mutants with conditional defects in immediate early gene expression.
Infections
Construction and properties of a mutant of herpes simplex virus type 1 with glycoprotein H coding sequences deleted.
Infections
Construction of a recombinant Anticarsia gemmatalis nucleopolyhedrovirus (AgMNPV-2D) harbouring the beta-galactosidase gene.
Infections
Cytotoxic effect of a replication-incompetent adenoviral vector with cytosine deaminase gene driven by L-plastin promoter in hepatocellular carcinoma cells.
Infections
Cytotoxic effects of Ad5CMV-p53 expression in two human nasopharyngeal carcinoma cell lines.
Infections
Decreased messenger RNA translation in herpesvirus-infected arterial cells: effects on cholesteryl ester hydrolase.
Infections
Defective herpes simplex virus vectors expressing the rat brain stress-inducible heat shock protein 72 protect cultured neurons from severe heat shock.
Infections
Dendritic morphology of cardiac related medullary neurons defined by circuit-specific infection by a recombinant pseudorabies virus expressing beta-galactosidase.
Infections
Development of an expression strategy using a lytic phage to trigger explosive plasmid amplification and gene expression.
Infections
Development of Engineered Bacteriophages for Escherichia coli Detection and High-Throughput Antibiotic Resistance Determination.
Infections
Development of Th1 imprints to rBCG expressing a foreign protein: implications for vaccination against HIV-1 and diverse influenza strains.
Infections
Differences in protein synthesis between wild type and intracellular growth-deficient strains of Legionella pneumophila in U937 and Acanthamoeba polyphaga.
Infections
Differential efficacy of adenoviral mediated gene transfer into cells from hematological cell lines and fresh hematological malignancies.
Infections
Disabled infectious single cycle herpes simplex virus (DISC-HSV) is a candidate vector system for gene delivery/expression of GM-CSF in human prostate cancer therapy.
Infections
E2F-1 gene therapy induces apoptosis and increases chemosensitivity in human pancreatic carcinoma cells.
Infections
Ectopic expression of Smad7 inhibits transforming growth factor-beta responses in vascular smooth muscle cells.
Infections
Effect of an adenoviral vector that expresses the canine p53 gene on cell growth of canine osteosarcoma and mammary adenocarcinoma cell lines.
Infections
Effect of infection with ribonucleic acid bacteriophage R23 on the inducible synthesis of beta-galactosidase in Escherichia coli.
Infections
Effect of mitochondrial and/or cytosolic glycerol 3-phosphate dehydrogenase overexpression on glucose-stimulated insulin secretion from MIN6 and HIT cells.
Infections
Effect of Partial Medium Replacement on Cell Growth and Protein Production for the High-Fivetrade mark insect cell line.
Infections
Efficacy of multiple administrations of a recombinant adenovirus expressing wild-type p53 in an immune-competent mouse tumor model.
Infections
Efficient adenovirus-mediated gene transfer into human blood monocyte-derived macrophages.
Infections
Efficient adenovirus-mediated gene transfer to gastric tissue by oral administration.
Infections
Efficient and selective adenovirus-mediated gene transfer into vascular neointima.
Infections
Efficient gene transfer and long-term expression in neurons using a recombinant adenovirus with a neuron-specific promoter.
Infections
Efficient gene transfer into cardiac myocytes using adeno-associated virus (AAV) vectors.
Infections
Efficient regulation of gene expression by adenovirus vector-mediated delivery of the CRE recombinase.
Infections
Efficient retrovirus-mediated cytokine-gene transduction of primary-cultured human glioma cells for tumor vaccination therapy.
Infections
Engineering regulable Escherichia coli beta-galactosidases as biosensors for anti-HIV antibody detection in human sera.
Infections
Enhanced selective gene expression by adenovirus vector using Cre/loxP regulation system for human carcinoembryonic antigen-producing carcinoma.
Infections
Enhanced transgene expression in urothelial cancer gene therapy with histone deacetylase inhibitor.
Infections
Enhancement of obliterative airway disease in rat tracheal allografts infected with recombinant rat cytomegalovirus.
Infections
Enhancement of the adenoviral sensitivity of human ovarian cancer cells by transient expression of coxsackievirus and adenovirus receptor (CAR).
Infections
Enhancer stimulation unmasks latent gene transfer after adenovirus-mediated gene delivery into human vascular smooth muscle cells.
Infections
eNOS gene transfer to vascular smooth muscle cells inhibits cell proliferation via upregulation of p27 and p21 and not apoptosis.
Infections
Evaluation of a genetically engineered cell line and a histochemical beta-galactosidase assay to detect herpes simplex virus in clinical specimens.
Infections
Evaluation of monitoring approaches and effects of culture conditions on recombinant protein production in baculovirus-infected insect cells.
Infections
Ex vivo and in vivo gene transfer to the skin using replication-deficient recombinant adenovirus vectors.
Infections
Excessive sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression causes increased sarcoplasmic reticulum Ca2+ uptake but decreases myocyte shortening.
Infections
Experimental gene therapy for an in vitro model of proliferative vitreoretinopathy.
Infections
Expression analysis of the matrix GLA protein and VE-cadherin gene promoters in the outflow pathway.
Infections
Expression of an adenovirus encoded reporter gene and its reactivation following UVC and oxidative damage in cultured fish cells.
Infections
Expression of antimicrobial peptide genes after infection by parasitoid wasps in Drosophila.
Infections
Expression of the calcium-binding protein, parvalbumin, in cultured cortical neurons using a HSV-1 vector system enhances NMDA neurotoxicity.
Infections
Expression of the prodrug-activating enzyme DT-diaphorase via Ad5 delivery to human colon carcinoma cells in vitro.
Infections
Expression of transgenes in normal and neoplastic anterior pituitary cells using recombinant adenoviruses: long term expression, cell cycle dependency, and effects on hormone secretion.
Infections
Factors influencing recombinant protein yields in an insect cell-bacuiovirus expression system: Multiplicity of infection and intracellular protein degradation.
Infections
Galectin-2 Has Bactericidal Effects against Helicobacter pylori in a ?-galactoside-Dependent Manner.
Infections
Gene dosage as a regulatory factor for gene expression. I. In lambda plac5-infected cells.
Infections
Gene transfer in bovine blastocysts using replication-defective retroviral vectors packaged with Gibbon ape leukemia virus envelopes.
Infections
Gene transfer in dendritic cells, induced by oral DNA vaccination with Salmonella typhimurium, results in protective immunity against a murine fibrosarcoma.
Infections
Genetic modification of the vessel wall. Comparison of surgical and catheter-based techniques for delivery of recombinant adenovirus.
Infections
Grafting genetically modified cells into the rat brain: characteristics of E. coli beta-galactosidase as a reporter gene.
Infections
Growth suppression of human ovarian cancer cell lines by the introduction of a p16 gene via a recombinant adenovirus.
Infections
Growth suppression of human ovarian cancer cells by adenovirus-mediated transfer of the PTEN gene.
Infections
HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses.
Infections
Herpes simplex type 1:lacZ recombinant viruses. I. Characterization and application to defining the mechanisms of action of known antiherpes agents.
Infections
Herpes simplex virus type 1 promoter activity during latency establishment, maintenance, and reactivation in primary dorsal root neurons in vitro.
Infections
High efficiency gene transfer into cultured primary rat and human hepatic stellate cells using baculovirus vectors.
Infections
Higher Throughput Quantification of Neutralizing Antibody to Herpes Simplex Viruses.
Infections
Highly efficient gene transfer into adult ventricular myocytes by recombinant adenovirus.
Infections
Human bone marrow stromal cells are efficiently transduced by vesicular stomatitis virus-pseudotyped retrovectors without affecting subsequent osteoblastic differentiation.
Infections
Human PBMC-derived dendritic cells transduced with an adenovirus vectorinduce cytotoxic T-lymphocyte responses against a vector-encoded antigen in vitro.
Infections
Identification of Streptococcus pneumoniae genes specifically induced in mouse lung tissues.
Infections
Immunomodulation by topical particle-mediated administration of cytokine plasmid DNA suppresses herpetic stromal keratitis without impairment of antiviral defense.
Infections
In vitro infection of megakaryocytes and their precursors by human cytomegalovirus.
Infections
In vivo and in vitro modulation of immune stimulatory capacity of primary dendritic cells by adenovirus-mediated gene transduction.
Infections
In vivo cytotoxicity of ovarian cancer cells through tumor-selective expression of the BAX gene.
Infections
In vivo marking of spontaneous or vaccine-induced fibrosarcomas in the domestic house cat, using an adenoviral vector containing a bifunctional fusion protein, GAL-TEK.
Infections
Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function.
Infections
Indicator expression directed by regulatory sequences of the glial fibrillary acidic protein (GFAP) gene: in vivo comparison of distinct GFAP-lacZ transgenes.
Infections
Inducible expression of a foreign gene inserted into the human cytomegalovirus genome.
Infections
Infection by bacterial pathogens expressing type III secretion decreases luciferase activity: ramifications for reporter gene studies.
Infections
Infection of cultured central nervous system neurons with a defective herpes simplex virus 1 vector results in stable expression of Escherichia coli beta-galactosidase.
Infections
Infection of cultured striatal neurons with a defective HSV-1 vector: implications for gene therapy.
Infections
Inflammation-Associated Senescence Promotes Helicobacter pylori-Induced Atrophic Gastritis.
Infections
Influence of expression and cis-acting sequences from avian leukosis viruses (ALVs) on stability of (ALV)-based retrovirus vectors.
Infections
Inhibition of beta-galactosidase synthesis in Escherichia coli after infection with different DNA and RNA phages.
Infections
Inhibition of HIV-1 replication by newly developed adamantane-containing polyanionic agents.
Infections
Inhibition of melanoma growth by adenoviral-mediated HSV thymidine kinase gene transfer in vivo.
Infections
Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor.
Infections
Innate and adaptive host response during the initial phase of herpes simplex virus encephalitis in the neonatal mouse.
Infections
Insertional mutagenesis of the murine cytomegalovirus genome: one prominent alpha gene (ie2) is dispensable for growth.
Infections
Integration of active human beta-galactosidase gene (100 kb) into genome using HSV/AAV amplicon vector.
Infections
International network for comparison of HIV neutralization assays: the NeutNet report.
Infections
Intestinal infection with Nematospiroides dubius selectively increases lactase expression by mouse jejunal enterocytes.
Infections
Intratumoral vaccination of adenoviruses expressing fusion protein RM4/tumor necrosis factor (TNF)-alpha induces significant tumor regression.
Infections
Isolation of a cell line for rapid and sensitive histochemical assay for the detection of herpes simplex virus.
Infections
Isolation of lambda amp3 genomic recombinants coding for antigens of Eimeria tenella.
Infections
Long-term expression in sensory neurons in tissue culture from herpes simplex virus type 1 (HSV-1) promoters in an HSV-1-derived vector.
Infections
Long-term expression of a foreign gene from a unique position in the latent herpes simplex virus genome.
Infections
Long-term transgene expression in mice infected with a herpes simplex virus type 1 mutant severely impaired for immediate-early gene expression.
Infections
Loss of epithelial integrity resulting from E-cadherin dysfunction predisposes airway epithelial cells to adenoviral infection.
Infections
Lutropin/choriogonadotropin stimulate the proliferation of primary cultures of rat Leydig cells through a pathway that involves activation of the extracellularly regulated kinase 1/2 cascade.
Infections
Manipulation of the cytoplasmic and transmembrane domains alters cell surface levels of the coxsackie-adenovirus receptor and changes the efficiency of adenovirus infection.
Infections
Maximization of recombinant protein yield in the insect cell/baculovirus system by one-time addition of nutrients to high-density batch cultures.
Infections
Microcarrier culture of lepidopteran cell lines: implications for growth and recombinant protein production.
Infections
Migrational analysis of the constitutively proliferating subependyma population in adult mouse forebrain.
Infections
Modification to the capsid of the adenovirus vector that enhances dendritic cell infection and transgene-specific cellular immune responses.
Infections
Modulation of gene expression after replication-deficient, recombinant adenovirus-mediated gene transfer by the product of a second adenovirus vector.
Infections
Modulation of host immune responses stimulated by Salmonella vaccine carrier strains by using different promoters to drive the expression of the recombinant antigen.
Infections
Molecular characterization of a phage-inducible middle promoter and its transcriptional activator from the lactococcal bacteriophage phi31.
Infections
Molecular cloning and expression of an immunodominant 53-kDa excretory-secretory antigen from Trichinella spiralis muscle larvae.
Infections
Moloney murine leukemia virus infects cells of the developing hair follicle after neonatal subcutaneous inoculation in mice.
Infections
Murine cytomegalovirus immediate-early promoter directs astrocyte-specific expression in transgenic mice.
Infections
Mutants of bacteriophage T4 deficient in the ability to induce nuclear disruption: shutoff of host DNA and protein synthesis gene dosage experiments, identification of a restrictive host, and possible biological significance.
Infections
N-acetylcysteine augments adenovirus-mediated gene expression in human endothelial cells by enhancing transgene transcription and virus entry.
Infections
Negative complementation of recA protein by recA1 polypeptide: in vivo recombination requires a multimeric form of recA protein.
Infections
Nerve growth factor is a potent inducer of proliferation and neuronal differentiation for adult rat chromaffin cells in vitro.
Infections
Neuron-targeted gene transfer by adenovirus carrying neural-restrictive silencer element.
Infections
Neuronal expression and regulation of CGRP promoter activity following viral gene transfer into cultured trigeminal ganglia neurons.
Infections
Nitric oxide from the inducible nitric oxide synthase (iNOS) increases the expression of cytochrome P450 2E1 in iNOS-null hepatocytes in the absence of inflammatory stimuli.
Infections
Nonessential genes of phage phiYeO3-12 include genes involved in adaptation to growth on Yersinia enterocolitica serotype O:3.
Infections
Optimal production of recombinant protein by the baculovirus-insect cell system in shake-flask culture with medium replacement.
Infections
Optimising fed-batch production of recombinant proteins using the baculovirus expression vector system.
Infections
Optimizing cardiovascular gene therapy: increased vascular gene transfer with modified adenoviral vectors.
Infections
Oral vaccination with modified vaccinia virus Ankara attached covalently to TMPEG-modified cationic liposomes overcomes pre-existing poxvirus immunity from recombinant vaccinia immunization.
Infections
Over-expression of hepatic neutral cytosolic cholesteryl ester hydrolase in mice increases free cholesterol and reduces expression of HMG-CoAR, CYP27, and CYP7A1.
Infections
Overexpression of mutated IkappaBalpha inhibits vascular smooth muscle cell proliferation and intimal hyperplasia formation.
Infections
p53 trans-dominantly suppresses tumor formation of human breast cancer cells mediated by retroviral bulk infection without marker gene selection: an expeditious in vitro protocol with implications towards gene therapy.
Infections
Parvoviruses are inefficient in inducing interferon-beta, tumor necrosis factor-alpha, or interleukin-6 in mammalian cells.
Infections
Perineurium originates from fibroblasts: demonstration in vitro with a retroviral marker.
Infections
Physiological and environmental factors affecting the growth of insect cells and infection with baculovirus.
Infections
Plant Disease and the Regulation of Enzymes Involved in Lignification: Increased Rate of De Novo Synthesis of the Three Tobacco O-Methyltransferases during the Hypersensitive Response to Infection by Tobacco Mosaic Virus.
Infections
Potential of a recombinant antigen as a prophylactic vaccine for day-old broiler chickens against Eimeria acervulina and Eimeria tenella infections.
Infections
Poxvirus as a vector to transduce human dendritic cells for immunotherapy: abortive infection but reduced APC function.
Infections
Practical aspects of the development of ex vivo and in vivo gene therapy for Parkinson's disease.
Infections
Prevention of herpes simplex virus infection and latency by prophylactic treatment with acyclovir in a weanling mouse model.
Infections
Priming of a beta-galactosidase (beta-GAL)-specific type 1 response in BALB/c mice infected with beta-GAL-transfected Leishmania major.
Infections
Production of a sialylated N-linked glycoprotein in insect cells: role of glycosidases and effect of harvest time on glycosylation.
Infections
Production of recombinant protein by baculovirus-infected insect cells in immobilized culture using porous biomass support particles.
Infections
Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer.
Infections
Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice.
Infections
Protein folding studies in vivo with a bacteriophage T4 expression-packaging-processing vector that delivers encapsidated fusion proteins into bacteria.
Infections
Quantification of cell culture factors affecting recombinant protein yields in baculovirus-infected insect cells.
Infections
Quiescent viral genomes in human fibroblasts after infection with herpes simplex virus type 1 Vmw65 mutants.
Infections
Rapid and stable gene expression in hippocampal slice cultures from a defective HSV-1 vector.
Infections
Rapid detection of HSV with an enzyme-linked virus inducible system (ELVIS) employing a genetically modified cell line.
Infections
Rapid identification and quantitation of cells infected by recombinant herpesvirus (pseudorabies virus) using a fluorescence-based beta-galactosidase assay and flow cytometry.
Infections
Rapid phenotypic drug susceptibility assay for HIV-1 with a CCR5 expressing indicator cell line.
Infections
Rapid production of interleukin-2-secreting tumor cells by herpes simplex virus-mediated gene transfer: implications for autologous vaccine production.
Infections
Recombinant adeno-associated virus for the generation of autologous, gene-modified tumor vaccines: evidence for a high transduction efficiency into primary epithelial cancer cells.
Infections
Recombinant adenovirus-transduced human dendritic cells engineered to secrete interleukin-10 (IL-10) suppress Th1-type responses while selectively activating IL-10-producing CD4+ T cells.
Infections
Recombinant fusion protein and DNA vaccines against foot and mouth disease virus infection in guinea pig and swine.
Infections
Recombinant Semliki forest virus infects and kills human prostate cancer cell lines and prostatic duct epithelial cells ex vivo.
Infections
Reduced synthesis of beta-galactosidase in Escherichia coli infected with phage phi X 174.
Infections
Reduction of islet amylin expression and basal secretion by adenovirus-mediated delivery of amylin antisense cDNA.
Infections
Regulated expression of the feline panleukopenia virus P38 promoter on extrachromosomal FPV/EBV chimeric plasmids.
Infections
Regulation of cytomegalovirus gene expression: alpha and beta promoters are trans activated by viral functions in permissive human fibroblasts.
Infections
Replication-defective virus infection of feather buds produces a localized region of beta-galactosidase activity.
Infections
Reporter gene expression in cell culture stages and oocysts of Eimeria nieschulzi (Coccidia, Apicomplexa).
Infections
Reproduction of antiviral effect in an in vivo model of human cytomegalovirus retinal infection.
Infections
Resolution of the pathway taken by implanted Schwann cells to a spinal cord lesion by prior infection with a retrovirus encoding beta-galactosidase.
Infections
Restriction of vaccinia virus replication in CHO cells occurs at the stage of viral intermediate protein synthesis.
Infections
Resurfacing of articular cartilage explants with genetically-modified human chondrocytes in vitro.
Infections
Retrograde and anterograde labeling of cerebellar afferent projection by the injection of recombinant adenoviral vectors into the mouse cerebellar cortex.
Infections
Retroviral infection and expression of cationic amino acid transporters in rodent hepatocytes.
Infections
Retroviral mediated transfer and expression of exogenous genes in primary lymphoid cells: assaying for a viral transactivator activity in normal and malignant cells.
Infections
Salmonella vaccine carrier strains: effective delivery system to trigger anti-tumor immunity by oral route.
Infections
Screening of insect cell lines for the production of recombinant proteins and infectious virus in the baculovirus expression system.
Infections
Significant increase of adenovirus infectivity in glioma cell lines by extracellular domain of hCAR.
Infections
Silencing of retroviral vector transduced LacZ reporter gene by frameshift mutation.
Infections
Site-specific gene expression in vivo by direct gene transfer into the arterial wall.
Infections
Site-specific stable insertion into the human cytomegalovirus genome of a foreign gene under control of the SV40 promoter.
Infections
Smooth muscle alpha-actin downregulation in cultured chick aortic smooth muscle and neural crest cells is associated with altered cell shape.
Infections
Streptococcus suis Type 2 SSU0587 Protein is a Beta-Galactosidase that Contributes to Bacterial Adhesion but Not to Virulence in Mice.
Infections
Strong and regulated expression of Escherichia coli beta-galactosidase in insect cells with a baculovirus vector.
Infections
Study of the chemical nature of Frp/3 cell recognition units for hepatitis A virus.
Infections
Sub-retroviral particles as gene transfer vectors that by-pass retrovirus-receptor interaction restrictions.
Infections
Successful retroviral mediated transduction of a reporter gene in human dendritic cells: feasibility of therapy with gene-modified antigen presenting cells.
Infections
Suicide gene expression induced in tumour cells transduced with recombinant adenoviral, retroviral and plasmid vectors containing the ERBB2 promoter.
Infections
Superinfection prevents recombination of the alphaherpesvirus bovine herpesvirus 1.
Infections
Suppression of neuronal and cardiac transient outward currents by viral gene transfer of dominant-negative Kv4.2 constructs.
Infections
T cell activation following infection of primary follicle center lymphoma B cells with adenovirus encoding CD154.
Infections
The 5' noncoding region sequence of the Choristoneura biennis entomopoxvirus spheroidin gene functions as an efficient late promoter in the mammalian vaccinia expression system.
Infections
The induction and kinetics of antigen-specific CD8 T cells are defined by the stage specificity and compartmentalization of the antigen in murine toxoplasmosis.
Infections
The organotypic multicellular spheroid is a relevant three-dimensional model to study adenovirus replication and penetration in human tumors in vitro.
Infections
The overexpression of copper-zinc superoxide dismutase protects NOS III from nitric oxide-mediated inhibition.
Infections
The phage promoter responsible for the expression of the inserted beta-galactosidase gene in bacteriophage lambda plac5.
Infections
The role of serpinb9/serine protease inhibitor 6 in preventing granzyme B-dependent hepatotoxicity.
Infections
The RR1 gene of herpes simplex virus type 1 is uniquely trans activated by ICP0 during infection.
Infections
Toxicity of replication-defective adenoviral recombinants in dissociated cultures of nervous tissue.
Infections
Transactivator protein BICP0 of bovine herpesvirus 1 (BHV-1) is blocked by prostaglandin D2 (PGD2), which points to a mechanism for PGD2-mediated inhibition of BHV-1 replication.
Infections
Transduction of the liver with activated Akt normalizes portal pressure in cirrhotic rats.
Infections
Trophic activity of Rabies G protein-pseudotyped equine infectious anemia viral vector mediated IGF-I motor neuron gene transfer in vitro.
Infections
Trypanosoma cruzi infection does not impair major histocompatibility complex class I presentation of antigen to cytotoxic T lymphocytes.
Infections
Use of a retroviral vector with an internal opsin promoter to direct gene expression to retinal photoreceptor cells.
Infections
Use of a stationary bed reactor and serum-free medium for the production of recombinant proteins in insect cells.
Infections
Use of L-plastin promoter to develop an adenoviral system that confers transgene expression in ovarian cancer cells but not in normal mesothelial cells.
Infections
Use of recombinant herpes simplex virus type 1 vectors for gene transfer into tumour and normal anterior pituitary cells.
Infections
Use of retroviral vectors to introduce and express the beta-galactosidase marker gene in cultured chicken primordial germ cells.
Infections
Utilization of the herpes simplex virus type 1 latency-associated regulatory region to drive stable reporter gene expression in the nervous system.
Infections
Utilization of trans-activated T4 uvsY regulatory signal for a high yield of cloned gene products.
Infections
Vaccinia as a tool for functional analysis in regenerating limbs: ectopic expression of Shh.
Infections
Vaccinia virus-bacteriophage T7 expression vector for complementation analysis of late gene processes.
Infections
Vasomotor dysfunction early after exposure of normal rabbit arteries to an adenoviral vector.
Infections
Visualization of a recombinant gene protein in the baculovirus expression vector system using confocal scanning laser microscopy.
Infections
[Expression of foreign genes in adult rats' central nervous system by use of defective herpes simplex virus type 1 vectors]
Infections
[Study of lysosomal enzymes in chick embryo fibroblasts infected with microorganisms of family Halprowiaceae (Chlamydiaceae)]
Infections
[Using reporter gene to compare infection efficiency of HIV-1 pseudovirus to suspended and adherent cells].
Infertility, Male
iTRAQ-based proteomic analysis of fertile and sterile flower buds from a genetic male sterile line 'AB01' in Chinese cabbage (Brassica campestris L. ssp. pekinensis).
Influenza, Human
Chondrocyte antigen expression, immune response and susceptibility to arthritis.
Influenza, Human
Complex structure of the nuclear translocation signal of influenza virus polymerase PA subunit.
Influenza, Human
Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle.
Influenza, Human
Myeloid dendritic cells stimulate both Th1 and Th2 immune responses depending on the nature of the antigen.
Influenza, Human
Removal of carbohydrate from influenza A virus and its hemagglutinin and the effect on biological activities.
Influenza, Human
TAP-dependent major histocompatibility complex class I presentation of soluble proteins using listeriolysin.
Influenza, Human
The role of carbohydrate in determining the immunochemical properties of the hemagglutinin of influenza A virus.
Influenza, Human
Transfectant influenza A viruses are effective recombinant immunogens in the treatment of experimental cancer.
Influenza, Human
[Role of carbohydrates in the manifestation of the hemagglutinating and neuraminidase activities of the influenza virus]
Influenza, Human
[The isolation and expression in E. coli of a recombinant plasmid containing the 3'-terminal fragment of the cDNA of the influenza A virus nucleoprotein gene]
Intellectual Disability
Generalized gangliosidosis: acid beta-galactosidase deficiency with early onset, rapid mental deterioration and minimal bone dysplasia.
Intellectual Disability
Juvenile neurogenic muscle atrophy with lysosomal enzyme deficiencies: new disease or variant of mucopolysaccharidosis?
Irritable Bowel Syndrome
Lactase and placebo in the management of the irritable bowel syndrome: a double-blind, cross-over study.
Kidney Diseases
Urinary acidic glycohydrolases as an index of kidney damage in juvenile diabetes mellitus.
lactase deficiency
An acidophilic beta-galactosidase from Bispora sp. MEY-1 with high lactose hydrolytic activity under simulated gastric conditions.
lactase deficiency
Enzyme replacement therapy for primary adult lactase deficiency. Effective reduction of lactose malabsorption and milk intolerance by direct addition of beta-galactosidase to milk at mealtime.
lactase deficiency
Separation and characterization of four enzyme forms of beta-galactosidase from Saccharomyces lactis.
Lactose Intolerance
A novel acid-stable, acid-active beta-galactosidase potentially suited to the alleviation of lactose intolerance.
Lactose Intolerance
Application relevant studies of fungal beta-galactosidases with potential application in the alleviation of lactose intolerance.
Lactose Intolerance
beta-Galactosidase from Aspergillus niger in adult lactose malabsorption: a double-blind crossover study.
Lactose Intolerance
Beta-galactosidase tablets in the treatment of lactose intolerance in pediatrics.
Lactose Intolerance
Effect of exogenous beta-galactosidase in patients with lactose malabsorption and intolerance: a crossover double-blind placebo-controlled study.
Lactose Intolerance
Effects of exogenous lactase administration on hydrogen breath excretion and intestinal symptoms in patients presenting lactose malabsorption and intolerance.
Lactose Intolerance
Efficacy testing of beta-galactosidase with H2 breath test in patients with carbohydrate malabsorption.
Lactose Intolerance
Engineering of a fungal beta-galactosidase to remove product inhibition by galactose.
Lactose Intolerance
Enzyme replacement for lactose malabsorption using a beta-D-galactosidase.
Lactose Intolerance
Enzyme replacement therapy for primary adult lactase deficiency. Effective reduction of lactose malabsorption and milk intolerance by direct addition of beta-galactosidase to milk at mealtime.
Lactose Intolerance
Frequency of lactose malabsorption among healthy southern and northern Indian populations by genetic analysis and lactose hydrogen breath and tolerance tests.
Lactose Intolerance
Genotyping of the lactase-phlorizin hydrolase -13910 polymorphism by LightCycler PCR and implications for the diagnosis of lactose intolerance.
Lactose Intolerance
Identification of bacteria with beta-galactosidase activity in faeces from lactase non-persistent subjects.
Lactose Intolerance
Improvement of lactose digestion in humans by ingestion of unfermented milk containing Bifidobacterium longum.
Lactose Intolerance
One step partial purification of beta-D-galactosidase from Kluyveromyces marxianus CDB 002 using STREAMLINE-DEAE.
Lactose Intolerance
Peroral gene therapy of lactose intolerance using an adeno-associated virus vector.
Lactose Intolerance
Production of yoghurt with mild taste by a Lactobacillus delbrueckii subsp. bulgaricus mutant with altered proteolytic properties.
Lactose Intolerance
Targeted PLGA-microparticles as a novel concept for treatment of lactose intolerance.
Lactose Intolerance
The effect of oral supplementation with Lactobacillus reuteri or tilactase in lactose intolerant patients: randomized trial.
Lactose Intolerance
The T-13910C polymorphism in the lactase phlorizin hydrolase gene is associated with differences in serum calcium levels and calcium intake.
Lactose Intolerance
Treatment of lactose intolerance with exogenous beta-D-galactosidase in pellet form.
Lactose Intolerance
Use of chemical mutagenesis for the isolation of food grade beta-galactosidase overproducing mutants of bifidobacteria, lactobacilli and Streptococcus thermophilus.
Latent Infection
A latent, nonpathogenic HSV-1-derived vector stably expresses beta-galactosidase in mouse neurons.
Latent Infection
beta-Gal enzyme activity driven by the HSV LAT promoter does not correspond to beta-gal RNA levels in mouse trigeminal ganglia.
Latent Infection
Decreased reporter gene expression during latent infection with HSV LAT promoter constructs.
Latent Infection
Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency.
Latent Infection
Long-term expression of a reporter gene from latent herpes simplex virus in the rat hippocampus.
Latent Infection
Prevention of herpes simplex virus infection and latency by prophylactic treatment with acyclovir in a weanling mouse model.
Latent Infection
Reactivation of latent cytomegalovirus infection in mouse brain cells detected after transfer to brain slice cultures.
Leiomyoma
Nonviral vector-mediated thymidine kinase gene transfer and ganciclovir treatment in leiomyoma cells.
Lentivirus Infections
[Kcnq1ot1 promotes osteogenic differentiation and suppresses osteoclast differentiation].
Leukemia
A latent, nonpathogenic HSV-1-derived vector stably expresses beta-galactosidase in mouse neurons.
Leukemia
A new system for stringent, high-titer vesicular stomatitis virus G protein-pseudotyped retrovirus vector induction by introduction of Cre recombinase into stable prepackaging cell lines.
Leukemia
A retroviral vector containing a muscle-specific enhancer drives gene expression only in differentiated muscle fibers.
Leukemia
Chemical modification of an ecotropic murine leukemia virus results in redirection of its target cell specificity.
Leukemia
Detection of in vivo differentiation of murine WEHI-3B D+ leukemia cells transfected with the lac-Z marker gene using two-color flow cytometry.
Leukemia
Development of a lacZ marked WEHI-3B D+ murine leukemic cell line as an in-vivo model of acute non-lymphocytic leukemia.
Leukemia
Development of a safe and rapid neutralization assay using murine leukemia virus pseudotyped with HIV type 1 envelope glycoprotein lacking the cytoplasmic domain.
Leukemia
Expression of human factor IX in mice after injection of genetically modified myoblasts.
Leukemia
Expression of Pax-3- and neuroectoderm-inducing activities during differentiation of P19 embryonal carcinoma cells.
Leukemia
Expression of the catalytic domain of myosin light chain kinase increases paracellular permeability.
Leukemia
Factors affecting long-term stability of Moloney murine leukemia virus-based vectors.
Leukemia
Human parainfluenza virus type 3: analysis of the cytoplasmic tail and transmembrane anchor of the hemagglutinin-neuraminidase protein in promoting cell fusion.
Leukemia
Inactivation of the Moloney murine leukemia virus long terminal repeat in murine fibroblast cell lines is associated with methylation and dependent on its chromosomal position.
Leukemia
Long-term expression of a reporter gene from latent herpes simplex virus in the rat hippocampus.
Leukemia
Optimization of human erythropoietin secretion from MLV-infected human primary fibroblasts used for encapsulated cell therapy.
Leukemia
Retroviral vector-mediated gene transfer into human primary myogenic cells leads to expression in muscle fibers in vivo.
Leukemia
Retrovirus-mediated transfer and expression of marker genes in the BN rat acute myelocytic leukemia model for the study of minimal residual disease (MRD).
Leukemia
Serum and host liver activities of glycosidases and sialyltransferases in animals bearing transplantable tumors.
Leukemia
Silencing of retroviral vector transduced LacZ reporter gene by frameshift mutation.
Leukemia
Successful transfection of biotinylated beta-galactosidase gene conjugated with transferrin into leukemia cells and interleukin-2-stimulated lymphocytes via transferrin receptor.
Leukemia
Targeting and gene expression in spinal cord motor neurons following intramuscular inoculation of an HSV-1 vector.
Leukemia
Targeting strategy for gene delivery to carcinoembryonic antigen-producing cancer cells by retrovirus displaying a single-chain variable fragment antibody.
Leukemia
Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins.
Leukemia
Telomere shortening and growth inhibition of human cancer cells by novel synthetic telomerase inhibitors MST-312, MST-295, and MST-1991.
Leukemia
Transient detection of beta-galactosidase activity in hematopoietic cells, following reinjection of retrovirally marked autologous blood progenitors in patients with breast or ovarian cancer receiving high-dose chemotherapy.
Leukemia
Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos.
Leukemia
Variable transduction efficiency of murine leukemia retroviral vector on mammalian cells: role of cellular glycosylation.
Leukemia
Y586F mutation in murine leukemia virus reverse transcriptase decreases fidelity of DNA synthesis in regions associated with adenine-thymine tracts.
Leukemia, Erythroblastic, Acute
Differential large-scale chromatin compaction and intranuclear positioning of transcribed versus non-transcribed transgene arrays containing beta-globin regulatory sequences.
Leukemia, Erythroblastic, Acute
Eosinophils inhibit retroviral transduction of human target cells by a ribonuclease-dependent mechanism.
Leukemia, Erythroblastic, Acute
Protein glycans alteration and a different distribution of some enzymatic activities involved in the glycan processing are found in AZT-treated K562 cells.
Leukemia, Erythroblastic, Acute
Recombinant adeno-associated virus-mediated gene transfer into hematopoietic progenitor cells.
Leukemia, Lymphocytic, Chronic, B-Cell
Gangliosides of human chronic lymphocytic leukemia and hairy cells.
Leukemia, Myeloid
1H NMR studies of a biosynthetic lacto-ganglio hybrid glycosphingolipid: confirmation of structure, interpretation of "anomalous" chemical shifts, and evidence for interresidue amide-amide hydrogen bonding.
Leukemia, Myeloid
Enzyme release assay of human NK cell activity using beta-galactosidase-expressing K562 target cell line.
Leukemia, Myeloid, Acute
Retrovirus-mediated transfer and expression of marker genes in the BN rat acute myelocytic leukemia model for the study of minimal residual disease (MRD).
Leukemia, T-Cell
Envelope proteins of human T-cell leukemia virus: expression in Escherichia coli and its application to studies of env gene functions.
Leukemia, T-Cell
Heterologous protein expression affects the death kinetics of baculovirus-infected insect cell cultures: a quantitative study by use of n-target theory.
Leukemia-Lymphoma, Adult T-Cell
Expression of the x-lor gene of human T-cell leukemia virus I in Escherichia coli.
Leukodystrophy, Globoid Cell
Chemical pathology of krabbe's disease. IV. Studies of galactosylceramide and lactosylceramide BETA-galactosidases in brain, white blood cells and aminotic fluid cells.
Leukodystrophy, Globoid Cell
Effect of bile salts on lactosylceramide beta-galactosidase activities in human brain, liver and cultured skin fibroblasts.
Leukodystrophy, Globoid Cell
Enzyme replacement with liposomes containing beta-galactosidase from Charonia lumpas in murine globoid cell leukodystrophy (twitcher).
Leukodystrophy, Globoid Cell
Galactosylceramide- and lactosylceramide-loading studies in cultured fibroblasts from normal individuals and patients with globoid cell leukodystrophy (Krabbe's disease) and GM1-gangliosidosis.
Leukodystrophy, Globoid Cell
Globoid cell leukodystrophy: deficiency of lactosyl ceramide beta-galactosidase.
Leukodystrophy, Globoid Cell
Hydrolysis of galactosylsphingosine and lactosylsphingosine by beta-galactosidases in human brain and cultured fibroblasts.
Leukodystrophy, Globoid Cell
Lactosylceramide beta-galactosidase in human sphingolipidoses. Evidence for two genetically distinct enzymes.
Leukodystrophy, Globoid Cell
Molecular beacon genotyping for globoid cell leukodystrophy from hair roots in the twitcher mouse and rhesus macaque.
Leukodystrophy, Globoid Cell
Prenatal enzymatic diagnosis and exclusion of Krabbe's disease (globoid-cell leukodystrophy) using chorionic villi in five risk pregnancies.
Leukodystrophy, Globoid Cell
Prenatal enzymatic diagnosis of Krabbe disease (globoid-cell leukodystrophy) using chorionic villi. Pitfalls in the use of uncultured villi.
Leukodystrophy, Globoid Cell
Prenatal enzymic diagnosis in 24 pregnancies with risk of Krabbe disease .
Leukodystrophy, Globoid Cell
Psychosine is as potent an inducer of cell death as C6-ceramide in cultured fibroblasts and in MOCH-1 cells.
Leukodystrophy, Globoid Cell
Residual galactosylsphingosine (psychosine) beta-galactosidase activities and associated GALC mutations in late and very late onset Krabbe disease.
Leukodystrophy, Globoid Cell
Specificity of galactosylceramidase activation by phosphatidylserine.
Leukodystrophy, Metachromatic
Juvenile-onset metachromatic leukodystrophy: biochemical and electrophysiologic studies.
Liver Cirrhosis
Increased serum alpha-L-fucosidase and beta-N-acetylglucosaminidase activities in diabetic, cirrhotic and gastric cancer patients.
Liver Cirrhosis, Biliary
Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: a possible role in bile duct loss.
Liver Cirrhosis, Biliary
Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence.
Liver Diseases
Detection by western blotting of an antibody to the hepatitis C virus E1 envelope protein in sera of patients with chronic liver disease.
Liver Failure, Acute
Cellular senescence in livers from children with end stage liver disease.
Liver Neoplasms
Development of pyrrolo[2,1-c][1,4]benzodiazepine beta-galactoside prodrugs for selective therapy of cancer by ADEPT and PMT.
Lumpy Skin Disease
Importance of thymidine kinase activity for normal growth of lumpy skin disease virus (SA-Neethling).
Lung Injury
Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury.
Lung Neoplasms
Apoptosis induced by depsipeptide FK228 coincides with inhibition of survival signaling in lung cancer cells.
Lung Neoplasms
Cell death induced by down-regulation of heat shock protein 70 in lung cancer cell lines is p53-independent and does not require DNA cleavage.
Lung Neoplasms
High levels of gene transduction in human lung tumors following intralesional injection of recombinant adenovirus.
Lung Neoplasms
IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death.
Lung Neoplasms
Induction of premature senescence in human lung cancer by fungal immunomodulatory protein from Ganoderma tsugae.
Lung Neoplasms
Longitudinal follow-up of cellular and humoral immunity induced by recombinant adenovirus-mediated gene therapy in cancer patients.
Lung Neoplasms
Phase I trial of recombinant adenovirus gene transfer in lung cancer. Longitudinal study of the immune responses to transgene and viral products.
Lung Neoplasms
Radiation-mediated up-regulation of gene expression from replication-defective adenoviral vectors: implications for sodium iodide symporter gene therapy.
Lung Neoplasms
Recombinant adenovirus shedding after intratumoral gene transfer in lung cancer patients.
Lung Neoplasms
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells.
Lung Neoplasms
Tumor-specific gene delivery mediated by a novel peptide-polyethylenimine-DNA polyplex targeting aminopeptidase N/CD13.
Lyme Disease
Activity of lysosomal exoglycosidases in the serum of patients with chronic Lyme arthritis.
Lyme Disease
Alpha fucosidase and beta galactosidase in serum of a Lyme disease patients as a possible marker of accelerated senescence - a preliminary study.
Lymphadenopathy
Suppression of autoimmune disease and of massive lymphadenopathy in MRL/Mp-lpr/lpr mice lacking tyrosine kinase Fyn (p59fyn).
Lymphocytic Choriomeningitis
The lymphocytic choriomeningitis virus envelope glycoprotein targets lentiviral gene transfer vector to neural progenitors in the murine brain.
Lymphoma
Efficient gene transfer into lymphoma cells using adenoviral vectors combined with lipofection.
Lymphoma
Efficient transduction of murine B lymphocytes and B lymphoma lines by modified adenoviral vectors: enhancement via targeting to FcR and heparan-containing proteins.
Lymphoma
Identification of the glucose transporter in mammalian cell membranes with a 125I-forskolin photoaffinity label.
Lymphoma
Live attenuated measles virus induces regression of human lymphoma xenografts in immunodeficient mice.
Lymphoma
Suitability of Epstein-Barr virus-based episomal vectors for expression of cytokine genes in human lymphoma cells.
Lymphoma
T cell activation following infection of primary follicle center lymphoma B cells with adenovirus encoding CD154.
Lymphoma, B-Cell
Suitability of Epstein-Barr virus-based episomal vectors for expression of cytokine genes in human lymphoma cells.
Lysosomal Storage Diseases
A case of galactosialidosis with a homozygous Q49R point mutation.
Lysosomal Storage Diseases
A duplication in the canine beta-galactosidase gene GLB1 causes exon skipping and GM1-gangliosidosis in Alaskan huskies.
Lysosomal Storage Diseases
A Single Injection of an Optimized Adeno-Associated Viral Vector into Cerebrospinal Fluid Corrects Neurological Disease in a Murine Model of GM1 Gangliosidosis.
Lysosomal Storage Diseases
Active-site motifs of lysosomal acid hydrolases: invariant features of clan GH-A glycosyl hydrolases deduced from hydrophobic cluster analysis.
Lysosomal Storage Diseases
Beta-galactosidase activity in fibroblasts and tissues from sheep with a lysosomal storage disease.
Lysosomal Storage Diseases
Cathepsin A deficiency in galactosialidosis: studies of patients and carriers in 16 families.
Lysosomal Storage Diseases
Cerebrospinal fluid biomarkers showing neurodegeneration in dogs with GM1 gangliosidosis: possible use for assessment of a therapeutic regimen.
Lysosomal Storage Diseases
Complete Correction of Enzymatic Deficiency and Neurochemistry in the GM1-gangliosidosis Mouse Brain by Neonatal Adeno-associated Virus-mediated Gene Delivery.
Lysosomal Storage Diseases
Diagnosis of unsuspected fetal metabolic storage disease by routine placental examination.
Lysosomal Storage Diseases
Elimination of abnormal sialylglycoproteins in fibroblasts with sialidosis and galactosialidosis by normal gene transfer and enzyme replacement.
Lysosomal Storage Diseases
Enhanced proteolytic degradation of normal beta-galactosidase in the lysosomal storage disease with combined beta-galactosidase and neuraminidase deficiency.
Lysosomal Storage Diseases
GM1 gangliosidosis and Morquio B disease: an update on genetic alterations and clinical findings.
Lysosomal Storage Diseases
Impact of beta-galactosidase mutations on the expression of the canine lysosomal multienzyme complex.
Lysosomal Storage Diseases
Inheritance of an ovine lysosomal storage disease associated with deficiencies of beta-galactosidase and alpha-neuraminidase.
Lysosomal Storage Diseases
Inherited lysosomal storage disease associated with deficiencies of beta-galactosidase and alpha-neuraminidase in sheep.
Lysosomal Storage Diseases
Interspecific genetic complementation analysis of human and sheep fibroblasts with beta-galactosidase deficiency.
Lysosomal Storage Diseases
Lectin histochemistry of an ovine lysosomal storage disease with deficiencies of beta-galactosidase and alpha-neuraminidase.
Lysosomal Storage Diseases
Mechanisms of distribution of mouse beta-galactosidase in the adult GM1-gangliosidosis brain.
Lysosomal Storage Diseases
Molecular mechanism of lysosomal sialidase deficiency in galactosialidosis involves its rapid degradation.
Lysosomal Storage Diseases
Molecular pathology of galactosialidosis in a patient affected with two new frameshift mutations in the cathepsin A/protective protein gene.
Lysosomal Storage Diseases
N-butyldeoxygalactonojirimycin reduces neonatal brain ganglioside content in a mouse model of GM1 gangliosidosis.
Lysosomal Storage Diseases
New mutations in two Dutch patients with early infantile galactosialidosis.
Lysosomal Storage Diseases
Rapid and accurate G M1-gangliosidosis diagnosis using a parentage testing microsatellite.
Lysosomal Storage Diseases
Six novel beta-galactosidase gene mutations in Brazilian patients with GM1-gangliosidosis.
Lysosomal Storage Diseases
Substrate reduction reduces gangliosides in postnatal cerebrum-brainstem and cerebellum in GM1 gangliosidosis mice.
Lysosomal Storage Diseases
The structures of six urinary oligosaccharides that are characteristic for a patient with Morquio syndrome type B.
Lysosomal Storage Diseases
Three novel beta-galactosidase gene mutations in Han Chinese patients with GM1 gangliosidosis are correlated with disease severity.
Lysosomal Storage Diseases
[The role of ophthalmological examination in the diagnosis of gangliosidosis GM1].
Malabsorption Syndromes
Intestinal beta-galactosidase activities in malabsorption syndromes.
Malaria
Conditional expression in the malaria mosquito Anopheles stephensi with Tet-On and Tet-Off systems.
Malaria
In Vitro Activities of MMV Malaria Box Compounds against the Apicomplexan Parasite Neospora caninum, the Causative Agent of Neosporosis in Animals.
Malaria
In vitro screening of the open source Pathogen Box identifies novel compounds with profound activities against Neospora caninum.
Malaria
OmpA fusion proteins for presentation of foreign antigens on the bacterial outer membrane.
Malaria
Recombinant Plasmodium falciparum glutamate rich protein; purification and use in enzyme-linked immunosorbent assay.
Malnutrition
Effect of prenatal exposure to ethanol on intestinal development of rat fetuses.
Malnutrition
Lactase phlorizin hydrolase synthesis is decreased in protein-malnourished pigs.
Malnutrition
Lactase synthesis is pretranslationally regulated in protein-deficient pigs fed a protein-sufficient diet.
Malnutrition
Neonatal undernutrition and short term administration of hydrocortisone and thyroxine: effects on rat brain hydrolases.
Massive Hepatic Necrosis
Cellular senescence in livers from children with end stage liver disease.
Measles
Construction of fowlpox virus vectors with intergenic insertions: expression of the beta-galactosidase gene and the measles virus fusion gene.
Measles
Synthesis of the membrane fusion and hemagglutinin proteins of measles virus, using a novel baculovirus vector containing the beta-galactosidase gene.
Melanoma
A melanoma cell line sensitive to expression of a fusion protein binding the retinoblastoma protein family pocket domain.
Melanoma
Adenoviral-mediated herpes simplex virus-thymidine kinase gene transfer in vivo for treatment of experimental human melanoma.
Melanoma
Adenovirus-mediated E2F-1 gene transfer efficiently induces apoptosis in melanoma cells.
Melanoma
Adenovirus-mediated E2F-1 gene transfer sensitizes melanoma cells to apoptosis induced by topoisomerase II inhibitors.
Melanoma
Distinct roles of adenovirus vector-transduced dendritic cells, myoblasts, and endothelial cells in mediating an immune response against a transgene product.
Melanoma
Down-regulation of p300/CBP histone acetyltransferase activates a senescence checkpoint in human melanocytes.
Melanoma
Elastin-derived peptides upregulate matrix metalloproteinase-2-mediated melanoma cell invasion through elastin-binding protein.
Melanoma
Evaluation of a nude mouse tumor model using beta-galactosidase-expressing melanoma cells.
Melanoma
Ex vivo and in vivo adenovirus-mediated gene therapy strategies induce a systemic anti-tumor immune defence in the B16 melanoma model.
Melanoma
Generation of an intensely potent anthracycline by a monoclonal antibody-beta-galactosidase conjugate.
Melanoma
In vitro and in vivo transfection of plasmid DNA in the Dunning prostate tumor R3327-AT1 is enhanced by focused ultrasound.
Melanoma
Inhibition of c-Myc oncoprotein limits the growth of human melanoma cells by inducing cellular crisis.
Melanoma
Melanoma-specific cytotoxicity induced by a tyrosinase promoter-enhancer/herpes simplex virus thymidine kinase adenovirus.
Melanoma
Nucleofection is a highly effective gene transfer technique for human melanoma cell lines.
Melanoma
Parathyroid Hormone-Related Peptide-Linked Hypercalcemia in a Melanoma Patient Treated With Ipilimumab: Hormone Source and Clinical and Metabolic Correlates.
Melanoma
Pro-Proliferative Function of Mitochondrial Sirtuin Deacetylase SIRT3 in Human Melanoma.
Melanoma
Repeated cationic multilamellar liposome-mediated gene transfer enhanced transduction efficiency against murine melanoma cell lines.
Melanoma
Simultaneous radiolabel, genetic tagging and proliferation assays to study the organ distribution and fate of metastatic cells.
Melanoma
Spleen tyrosine kinase functions as a tumor suppressor in melanoma cells by inducing senescence-like growth arrest.
Melanoma
Therapeutic immune response induced by electrofusion of dendritic and tumor cells.
Melanoma
Transcriptional targeting of recombinant adenoviruses to human and murine melanoma cells.
Melanoma
Tumor suppression without differentiation or apoptosis by antisense cyclin D1 gene transfer in K1735 melanoma involves induction of p53, p21WAF1 and superoxide dismutases.
Melanoma
[Establishment of mouse melanoma model expressing beta-galactosidase and its application in the research of DNA vaccines against tumor]
Melanoma, Amelanotic
The phototumorigenic fluoroquinolone, lomefloxacin, photosensitises p53 accumulation and transcriptional activity in human skin cells.
Melanoma, Experimental
A flow cytometric method for the rapid detection of beta-galactosidase transfected cells: an in vitro and in vivo study.
Melanoma, Experimental
Comparative analysis of antigen loading strategies of dendritic cells for tumor immunotherapy.
Melanoma, Experimental
Ex vivo and in vivo adenovirus-mediated gene therapy strategies induce a systemic anti-tumor immune defence in the B16 melanoma model.
Meningioma
Gene dosage effect in cells with monosomy of chromosome 22 derived from human meningiomas.
Mesenteric Lymphadenitis
Increased activity of lysosomal enzymes in the peritoneal fluid of bacterial peritonitis.
Mesothelioma
Immuno-gene therapy with interferon-beta before surgical debulking delays recurrence and improves survival in a murine model of malignant mesothelioma.
Mesothelioma
Transfer into a mesothelioma cell line of tumor suppressor gene p16 by cholesterol-based cationic lipids.
Mesothelioma, Malignant
Direct in vivo gene transfer and expression in malignant cells using adenovirus vectors.
Mesothelioma, Malignant
In vivo transfer of bacterial marker genes results in differing levels of gene expression and tumor progression in immunocompetent and immunodeficient mice.
Metabolism, Inborn Errors
Immunostaining of human amniotic epithelial cells: possible use as a transgene carrier in gene therapy for inborn errors of metabolism.
Mouth Neoplasms
Serum decreases the size of Metafectene-and Genejammer-DNA complexes but does not affect significantly their transfection activity in SCCVII murine squamous cell carcinoma cells.
Mucolipidoses
A comparative study of sialyloligosaccharides isolated from sialidosis and galactosialidosis urine.
Mucolipidoses
A new type of mucolipidosis with beta-galactosidase dificiency and glycopeptiduria.
Mucolipidoses
Adult type mucolipidosis with beta-galactosidase and sialidase deficiency. Histological and biochemical studies.
Mucolipidoses
Application of epithelial cells in culture to the biochemical studies of lysosomal hydrolase deficiencies.
Mucolipidoses
beta-Galactosidase deficient-type mucolipidosis: a complementation study of neuraminidase in somatic cell hybrids.
Mucolipidoses
beta-Galactosidase in mucopolysaccharidoses and mucolipidoses. Deficiency of GM1 beta-galactosidase in liver and leukocytes.
Mucolipidoses
Carrier detection of sialidosis with partial beta-galactosidase deficiency by the assay of lysosomal sialidase in lymphocytes.
Mucolipidoses
Characterization of human lysosomal neuraminidase defines the molecular basis of the metabolic storage disorder sialidosis.
Mucolipidoses
Cloning of the cDNA and gene encoding mouse lysosomal sialidase and correction of sialidase deficiency in human sialidosis and mouse SM/J fibroblasts.
Mucolipidoses
Early proteolytic cleavage with loss of a C-terminal fragment underlies altered processing of the beta-galactosidase precursor in galactosialidosis.
Mucolipidoses
Electron microscopic examination of skin and conjunctival biopsy specimens in neuronal storage diseases.
Mucolipidoses
Electrophoretic analysis of glycoprotein enzymes in the sialidoses and mucolipidoses.
Mucolipidoses
Elimination of abnormal sialylglycoproteins in fibroblasts with sialidosis and galactosialidosis by normal gene transfer and enzyme replacement.
Mucolipidoses
Exclusion of NEU1 and PPGB from candidate genes for a lysosomal storage disease in Japanese Black cattle.
Mucolipidoses
Four positional isomers of sialyloligosaccharides isolated from the urine of a patient with sialidosis.
Mucolipidoses
Human beta-galactosidase and alpha-neuraminidase deficient mucolipidosis: genetic complementation analysis of the neuraminidase deficiency.
Mucolipidoses
I-Cell disease: isoelectric focusing, concanavalin A-Sepharose 4B binding and kinetic properties of human liver acid beta-D-galactosidases.
Mucolipidoses
Km defect in neuraminidase of dysmorphic type sialidosis with and without beta-galactosidase deficiency.
Mucolipidoses
Lymphoblastoid cell lines, transformed by Epstein-Barr virus, in the enzymatic study of hereditary lysosomal storage diseases.
Mucolipidoses
Lysosomal hydrolases in blood-derived macrophages of patients with I-cell disease.
Mucolipidoses
Lysosomal sialidase deficiency in sialidosis with partial beta-galactosidase deficiency.
Mucolipidoses
Measurement of Elevated Concentrations of Urine Keratan Sulfate by UPLC-MSMS in Lysosomal Storage Disorders (LSDs): Comparison of Urine Keratan Sulfate Levels in MPS IVA Versus Other LSDs.
Mucolipidoses
Metabolic disorders characterized by angiokeratomas and neurologic dysfunction.
Mucolipidoses
Mucolipidosis II and III: different residual activity of beta-galactosidase in cultured fibroblasts.
Mucolipidoses
Neuraminidase deficiency and accumulation of sialic acid in lymphocytes in adult type sialidosis with partial beta-galactosidase deficiency.
Mucolipidoses
Neuraminidase in mucolipidoses: normal activity in frozen autopsy tissues from three patients with I-cell disease and adult beta-galactosidase deficiency.
Mucolipidoses
Neurochemical abnormality in I-cell disease: chemical analysis and a possible importance of beta-galactosidase deficiency.
Mucolipidoses
Partial characterization and studies of fibroblast and leucocyte neuraminidase activities towards sialyloligosaccharides in adult sialidosis and mucolipidosis II and III.
Mucolipidoses
Prenatal diagnosis of sialidosis with combined neuraminidase and beta-galactosidase deficiency.
Mucolipidoses
Properties of acid beta-D-galactosidase isolated from I-cell disease brain and spleen.
Mucolipidoses
Radioassay method of neuraminidase towards N-acetylneuraminosyl hexasaccharides.
Mucolipidoses
Signaling pathways transduced through the elastin receptor facilitate proliferation of arterial smooth muscle cells.
Mucolipidoses
Structure of a novel sialooligosaccharide from the urine of a patient with mucolipidosis.
Mucolipidoses
The complementation of beta-galactosidase in fused cells of mucolipidosis II with another variants of beta-galactosidase deficiency using new single cell enzyme assay.
Mucolipidoses
Transport of human lysosomal neuraminidase to mature lysosomes requires protective protein/cathepsin A.
Mucolipidoses
Two positional isomers of sialylheptasaccharides isolated from the urine of a patient with sialidosis.
Mucolipidoses
Ultrastructural and immunocytochemical study of skin fibroblasts from normal and sialidosis patients.
Mucolipidoses
Urinary sialyloligosaccharides in adult type sialidosis: occurrence of two positional isomers.
Mucolipidoses
[A case of adult type sialidosis with partial beta-galactosidase deficiency without myoclonus]
Mucolipidoses
[Adult mucolipidosis with beta-galactosidase deficiency: a clinical report, with studies of urinary sialic acid-rich substances (author's transl)]
Mucolipidoses
[Sialidosis and galactosialidosis as the cause of non-immunologic hydrops fetalis]
Mucopolysaccharidoses
An improved method for the detection of beta-galactosidase activity, and its application to G MI-gangliosidosis and mucopolysaccharidosis.
Mucopolysaccharidoses
beta-Galactosidase in mucopolysaccharidoses and mucolipidoses. Deficiency of GM1 beta-galactosidase in liver and leukocytes.
Mucopolysaccharidoses
Interspecific genetic complementation analysis of human and sheep fibroblasts with beta-galactosidase deficiency.
Mucopolysaccharidoses
Morquio B patient/caregiver survey: First insight into the natural course of a rare GLB1 related condition.
Mucopolysaccharidoses
Mutation analyses in 17 patients with deficiency in acid beta-galactosidase: three novel point mutations and high correlation of mutation W273L with Morquio disease type B.
Mucopolysaccharidoses
Novel beta-galactosidase gene mutation p.W273R in a woman with mucopolysaccharidosis type IVB (Morquio B) and lack of response to in vitro chaperone treatment of her skin fibroblasts.
Mucopolysaccharidoses
[Morquio syndrome moderated by beta galactosidase deficiency. Mucopolysaccharidosis (type IV B) or oligosaccharidosis]
Mucopolysaccharidoses
[Mucopolysaccharidosis type IV (Morquio syndrome, beta-galactosidase deficiency)]
Mucopolysaccharidoses
[Ophthalmologic and roentgenologic findings in a rare case of mucopolysaccharidosis 4 B]
Mucopolysaccharidosis I
Acid hydrolases in skin and plasma in gargoylism. Deficiency of beta-galactosidase in skin.
Mucopolysaccharidosis I
Deficiency of beta-galactosidase and alpha-mannosidase--primary enzyme defects in gargoylism and a new generalized disease?
Mucopolysaccharidosis I
Electron microscopic examination of skin and conjunctival biopsy specimens in neuronal storage diseases.
Mucopolysaccharidosis I
Hurler syndrome: alpha-L-iduronidase activity in leukocytes as a method for heterozygote detection.
Mucopolysaccharidosis I
Hurler's syndrome: deficiency of a specific beta galactosidase isoenzyme.
Mucopolysaccharidosis I
Lymphoblastoid cell lines, transformed by Epstein-Barr virus, in the enzymatic study of hereditary lysosomal storage diseases.
Mucopolysaccharidosis II
Glycosidases in skin and plasma in Hunter's syndrome. Abnormality of a beta-galactosidase in skin.
Mucopolysaccharidosis IV
A beta-galactosidase gene mutation identified in both Morquio B disease and infantile GM1 gangliosidosis.
Mucopolysaccharidosis IV
Alternative splicing of beta-galactosidase mRNA generates the classic lysosomal enzyme and a beta-galactosidase-related protein.
Mucopolysaccharidosis IV
An autophagic vacuolar myopathy-like disorder presenting as nonimmune hydrops in a female fetus.
Mucopolysaccharidosis IV
Atypical adult GM1 gangliosidosis: biochemical comparison with other forms of primary beta-galactosidase deficiency.
Mucopolysaccharidosis IV
Beta-galactosidase deficiencies and novel GLB1 mutations in three Chinese patients with Morquio B disease or GM1 gangliosidosis.
Mucopolysaccharidosis IV
Correction of acid beta-galactosidase deficiency in GM1 gangliosidosis human fibroblasts by retrovirus vector-mediated gene transfer: higher efficiency of release and cross-correction by the murine enzyme.
Mucopolysaccharidosis IV
Electron microscopic examination of skin and conjunctival biopsy specimens in neuronal storage diseases.
Mucopolysaccharidosis IV
Expression and characterization of 14 GLB1 mutant alleles found in GM1-gangliosidosis and Morquio B patients.
Mucopolysaccharidosis IV
Generalized gangliosidosis: acid beta-galactosidase deficiency with early onset, rapid mental deterioration and minimal bone dysplasia.
Mucopolysaccharidosis IV
GM1 gangliosidosis and Morquio B disease: an update on genetic alterations and clinical findings.
Mucopolysaccharidosis IV
GM1 gangliosidosis and Morquio B disease: expression analysis of missense mutations affecting the catalytic site of acid beta-galactosidase.
Mucopolysaccharidosis IV
Imbalanced substrate specificity of mutant beta-galactosidase in patients with Morquio B disease.
Mucopolysaccharidosis IV
Impaired elastic-fiber assembly by fibroblasts from patients with either Morquio B disease or infantile GM1-gangliosidosis is linked to deficiency in the 67-kD spliced variant of beta-galactosidase.
Mucopolysaccharidosis IV
Incorporation and degradation of GM1 ganglioside and asialoGM1 ganglioside in cultured fibroblasts from normal individuals and patients with beta-galactosidase deficiency.
Mucopolysaccharidosis IV
Insertion of a T next to the donor splice site of intron 1 causes aberrantly spliced mRNA in a case of infantile GM1-gangliosidosis.
Mucopolysaccharidosis IV
Interspecific genetic complementation analysis of human and sheep fibroblasts with beta-galactosidase deficiency.
Mucopolysaccharidosis IV
Intracellular processing and maturation of mutant gene products in hereditary beta-galactosidase deficiency (beta-galactosidosis).
Mucopolysaccharidosis IV
Late diagnosis of mucopolysaccharidosis type IVB and successful aortic valve replacement in a 60-year-old female patient.
Mucopolysaccharidosis IV
Measurement of Elevated Concentrations of Urine Keratan Sulfate by UPLC-MSMS in Lysosomal Storage Disorders (LSDs): Comparison of Urine Keratan Sulfate Levels in MPS IVA Versus Other LSDs.
Mucopolysaccharidosis IV
Molecular basis of GM1 gangliosidosis and Morquio disease, type B. Structure-function studies of lysosomal beta-galactosidase and the non-lysosomal beta-galactosidase-like protein.
Mucopolysaccharidosis IV
Molecular form and subcellular distribution of acid beta-galactosidase in fibroblasts from patients with GM1 gangliosidosis, Morquio B disease and galactosialidosis.
Mucopolysaccharidosis IV
Morquio B patient/caregiver survey: First insight into the natural course of a rare GLB1 related condition.
Mucopolysaccharidosis IV
Morquio syndrome (mucopolysaccharidosis IV B) associated with beta-galactosidase deficiency. Report of two cases.
Mucopolysaccharidosis IV
Morquio's disease type B (beta-galactosidase deficiency) in three siblings.
Mucopolysaccharidosis IV
Morquio-B disease, spondyloepiphyseal dysplasia associated with acid beta-galactosidase deficiency. Report of three cases in one family.
Mucopolysaccharidosis IV
Morquio-like syndrome with beta galactosidase deficiency and normal hexosamine sulfatase activity: mucopolysacchariodosis IVB.
Mucopolysaccharidosis IV
Mutation analyses in 17 patients with deficiency in acid beta-galactosidase: three novel point mutations and high correlation of mutation W273L with Morquio disease type B.
Mucopolysaccharidosis IV
Novel beta-galactosidase gene mutation p.W273R in a woman with mucopolysaccharidosis type IVB (Morquio B) and lack of response to in vitro chaperone treatment of her skin fibroblasts.
Mucopolysaccharidosis IV
Novel mutations (Asn 484 Lys, Thr 500 Ala, Gly 438 Glu) in Morquio B disease.
Mucopolysaccharidosis IV
Organization of the gene encoding human lysosomal beta-galactosidase.
Mucopolysaccharidosis IV
Processing of human beta-galactosidase in GM1-gangliosidosis and Morquio B syndrome.
Mucopolysaccharidosis IV
Progressive mental regression in siblings with Morquio disease type B (mucopolysaccharidosis IV B).
Mucopolysaccharidosis IV
The effects of acid glycosaminoglycans on neonatal calvarian cultures--a role of keratan sulfate in Morquio syndrome?
Mucopolysaccharidosis IV
The structures of six urinary oligosaccharides that are characteristic for a patient with Morquio syndrome type B.
Mucopolysaccharidosis IV
Twenty-one novel mutations in the GLB1 gene identified in a large group of GM1-gangliosidosis and Morquio B patients: possible common origin for the prevalent p.R59H mutation among gypsies.
Mucopolysaccharidosis IV
[Late diagnosis of Morquio syndrome. Clinical histopathological findings in a rare mucopolysaccharidosis]
Mucopolysaccharidosis IV
[Molecular genetics of beta-galactosidase deficiency (GM1-gangliosidosis and Morquio syndrome type B)]
Mucopolysaccharidosis IV
[Morquio syndrome moderated by beta galactosidase deficiency. Mucopolysaccharidosis (type IV B) or oligosaccharidosis]
Mucopolysaccharidosis IV
[Mucopolysaccharidosis type IV (Morquio syndrome, beta-galactosidase deficiency)]
Mucopolysaccharidosis IV
[Ophthalmologic and roentgenologic findings in a rare case of mucopolysaccharidosis 4 B]
Multiple Sclerosis
Diagnostic value of determinations of lysosomal hydrolases in CSF of patients with neurological diseases.
Muscular Atrophy
Adult type GMl-gangliosidosis: a complementation study on somatic cell hybrids.
Muscular Atrophy
Juvenile neurogenic muscle atrophy with lysosomal enzyme deficiencies: new disease or variant of mucopolysaccharidosis?
Muscular Diseases
Dysferlin expression after normal myoblast transplantation in SCID and in SJL mice.
Muscular Dystrophies
Dysferlin expression after normal myoblast transplantation in SCID and in SJL mice.
Muscular Dystrophies
Limitations of nls beta-galactosidase as a marker for studying myogenic lineage or the efficacy of myoblast transfer.
Muscular Dystrophies
Restricted expression of cardiac myosin light chain 2A gene in muscular dystrophic condition.
Muscular Dystrophies
Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system.
Muscular Dystrophies, Limb-Girdle
Dysferlin expression after normal myoblast transplantation in SCID and in SJL mice.
Muscular Dystrophies, Limb-Girdle
Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system.
Myeloproliferative Disorders
Gene dosage effect for beta-glucuronidase (GUSB) in monosomy 7 cells of patients with myeloproliferative disorders.
Myeloproliferative Disorders
Platelet lysosomal enzymes are normal in myeloproliferative disorders.
Myocardial Infarction
Adenovirus-mediated gene transfer into infarcted myocardium: feasibility, timing, and location of expression.
Myocardial Infarction
Adenovirus-mediated overexpression of inhibitor kappa B-alpha attenuates postinfarct remodeling in the rat heart.
Myocardial Infarction
Can cold or heat shock improve skeletal myoblast engraftment in infarcted myocardium?
Myocardial Infarction
Influence of isoproterenol-induced myocardial infarction on certain glycohydrolases and cathepsins in rats.
Myocardial Infarction
Interventional magnetic resonance imaging for guiding gene and cell transfer in the heart.
Myocardial Infarction
Ischemic/reperfused myocardium can express recombinant protein following direct DNA or retroviral injection.
Myocardial Infarction
Serum and urinary beta-galactosidase and beta-glucuronidase activity in patients with acute myocardial infarction.
Myocardial Infarction
Serum beta-N-acetylglucosaminidase, beta-D-glucosidase, alpha-D-glucosidase, beta-D-fucosidase, alpha-L-fucosidase and beta-D-galactosidase levels in acute viral hepatitis, pancreatitis, myocardial infarction and breast cancer.
Myocardial Infarction
Synergistic effect of nicorandil and amlodipine on lysosomal hydrolases during experimental myocardial infarction in rats.
Myocardial Infarction
Use of recombinant adeno-associated viral vectors as a tool for labeling bone marrow cells.
Myocardial Ischemia
Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction.
Myocardial Ischemia
[Endothelial cell senescence in human atherosclerosis: role of telomeres in endothelial dysfunction]
Myocardial Ischemia
[Therapeutic angiogenesis with the use of vascular endothelial growth factor 165 gene in the myocardium of miniature swine]
Myocarditis
Linking immune-mediated arterial inflammation and cholesterol-induced atherosclerosis in a transgenic mouse model.
Myoclonus
Adult GM1 gangliosidosis: clinical and biochemical studies on two patients and comparison to other patients called variant or adult GM1 gangliosidosis.
Myoclonus
Localized beta-galactosidase deficiency. Occurrence in cerebellar ataxia with myoclonus epilepsy and macular cherry-red spot--a new variant of GM1-gangliosidosis?
Myoclonus
Macular cherry-red spots and beta-galactosidase deficiency in an adult. An autopsy case with progressive cerebellar ataxia, myoclonus, thrombocytopathy, and accumulation of polysaccharide in liver.
Myoclonus
Macular cherry-red spots and myoclonus with dementia: coexistent neuraminidase and beta-galactosidase deficiencies.
Myoclonus
Neuraminidase in mucolipidoses: normal activity in frozen autopsy tissues from three patients with I-cell disease and adult beta-galactosidase deficiency.
Myoclonus
[A case of adult type sialidosis with partial beta-galactosidase deficiency without myoclonus]
Myotonic Dystrophy
Mice deficient in Six5 develop cataracts: implications for myotonic dystrophy.
Nasopharyngeal Carcinoma
Evidence of cisplatin-induced senescent-like growth arrest in nasopharyngeal carcinoma cells.
Neoplasm Metastasis
Chemoembolisation of rat colorectal liver metastases with drug eluting beads loaded with irinotecan or doxorubicin.
Neoplasm Metastasis
Combination treatment of CC531-lac-Z rat liver metastases by chemoembolization with pemetrexed disodium and gemcitabine.
Neoplasm Metastasis
Comparative studies between nude and scid mice on the growth and metastatic behavior of xenografted human tumors.
Neoplasm Metastasis
Costimulation enhances the active immunotherapy effect of recombinant anticancer vaccines.
Neoplasm Metastasis
Decreased metastatic spread in mice homozygous for a null allele of the cystatin C protease inhibitor gene.
Neoplasm Metastasis
Dendritic cells retrovirally transduced with a model antigen gene are therapeutically effective against established pulmonary metastases.
Neoplasm Metastasis
Direct evidence of the importance of stromal urokinase plasminogen activator (uPA) in the growth of an experimental human breast cancer using a combined uPA gene-disrupted and immunodeficient xenograft model.
Neoplasm Metastasis
Dissemination in athymic nude mice of lacZ transfected small cell lung cancer cells identified by X-gal staining.
Neoplasm Metastasis
Early characterization of a novel metastatic disease model of murine neuroblastoma.
Neoplasm Metastasis
Gene transfer of the vascular endothelial growth factor receptor flt-1 suppresses pulmonary metastasis associated with lung growth.
Neoplasm Metastasis
In vivo gene transfer of pigment epithelium-derived factor inhibits tumor growth in syngeneic murine models of thoracic malignancies.
Neoplasm Metastasis
Interleukin-10 enhances the therapeutic effectiveness of a recombinant poxvirus-based vaccine in an experimental murine tumor model.
Neoplasm Metastasis
Invasion-inhibiting factor 2-albumin conjugate inhibits invasion and spontaneous metastasis of MKL-4 human breast cancer cells transplanted into female nude mice.
Neoplasm Metastasis
Quantitative detection of lac-Z-transfected CC531 colon carcinoma cells in an orthotopic rat liver metastasis model.
Neoplasm Metastasis
Recombinant E1-deleted adenovirus-mediated gene therapy for cancer: efficacy studies with p53 tumor suppressor gene and liver histology in tumor xenograft models.
Neoplasm Metastasis
Simultaneous radiolabel, genetic tagging and proliferation assays to study the organ distribution and fate of metastatic cells.
Neoplasm Metastasis
Systemic treatment with a recombinant erbB-2 receptor-specific tumor toxin efficiently reduces pulmonary metastases in mice injected with genetically modified carcinoma cells.
Neoplasm Metastasis
The activity of serum beta-galactosidase in colon cancer patients with a history of alcohol and nicotine dependence: preliminary data.
Neoplasm Micrometastasis
Development of micrometastases: earliest events detected with bacterial lacZ gene-tagged tumor cells.
Neoplasm Micrometastasis
Gene therapy of metastatic cancer by in vivo retroviral gene targeting.
Neoplasm Micrometastasis
Growth characteristics in the initial stage of micrometastasis formation by bacterial LacZ gene-tagged rat prostatic adenocarcinoma cells.
Neoplasm Micrometastasis
Plasma Escherichia coli beta-galactosidase as a marker of tumor burden and response to experimental anti-neoplastic therapy in nude mice xenografted with lacZ transduced human tumor cells.
Neoplasm Micrometastasis
Quantitative demonstration of spontaneous metastasis by MCF-7 human breast cancer cells cotransfected with fibroblast growth factor 4 and LacZ.
Neoplasm, Residual
Antitumor effect and cellular immunity activation by murine interferon-beta gene transfer against intracerebral glioma in mouse.
Neoplasm, Residual
Retrovirus-mediated transfer and expression of marker genes in the BN rat acute myelocytic leukemia model for the study of minimal residual disease (MRD).
Neoplasms
A 19F-NMR approach using reporter molecule pairs to assess beta-galactosidase in human xenograft tumors in vivo.
Neoplasms
A beta-galactosidase hybrid protein targeted to nuclei as a marker for developmental studies.
Neoplasms
A model system for testing gene vectors using murine tumor cells on the chorioallantoic membrane of the chick embryo.
Neoplasms
A mouse embryonic stem cell line showing pluripotency of differentiation in early embryos and ubiquitous beta-galactosidase expression.
Neoplasms
A multifunctional PEI-based cationic polyplex for enhanced systemic p53-mediated gene therapy.
Neoplasms
A new immunocapture assay for Escherichia coli beta-galactosidase for in vivo studies of lacZ-transduced tumor cells.
Neoplasms
A novel nonviral cytoplasmic gene expression system and its implications in cancer gene therapy.
Neoplasms
Ablation of tumor cells in vivo by direct injection of HSV-thymidine kinase retroviral vector and ganciclovir therapy.
Neoplasms
Active immunotherapy of cancer with a nonreplicating recombinant fowlpox virus encoding a model tumor-associated antigen.
Neoplasms
Activity assays of nine heterogeneous promoters in neural and other cultured cells.
Neoplasms
Activity of the dietary antioxidant ergothioneine in a virus gene-based assay for inhibitors of HIV transcription.
Neoplasms
Acute cytokine response to systemic adenoviral vectors in mice is mediated by dendritic cells and macrophages.
Neoplasms
ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells.
Neoplasms
Adenoviral delivery of B7-1 (CD80) increases the immunogenicity of human ovarian and cervical carcinoma cells.
Neoplasms
Adenoviral-mediated delivery of herpes simplex virus thymidine kinase results in tumor reduction and prolonged survival in a SCID mouse model of human ovarian carcinoma.
Neoplasms
Adenoviral-mediated expression of a kinase-dead mutant of Akt induces apoptosis selectively in tumor cells and suppresses tumor growth in mice.
Neoplasms
Adenoviral-mediated gene therapy of human bladder cancer with antisense interleukin-8.
Neoplasms
Adenovirus 5 E1a-mediated gene therapy for human ovarian cancer cells in vitro and in vivo.
Neoplasms
Adenovirus encoding soluble tumor necrosis factor alpha receptor immunoglobulin prolongs gene expression of a cotransfected reporter gene in rat lung.
Neoplasms
Adenovirus gene transfer vectors inhibit growth of lymphatic tumor metastases independent of a therapeutic transgene.
Neoplasms
Adenovirus vector-mediated gene transfer using degradable starch microspheres for hepatocellular carcinoma in rats.
Neoplasms
Adenovirus-directed expression of Q227L-G alpha(s) inhibits growth of established tumors of later-stage human breast cancer cells in athymic mice.
Neoplasms
Adenovirus-mediated combined P16 gene and GM-CSF gene therapy for the treatment of established tumor and induction of antitumor immunity.
Neoplasms
Adenovirus-mediated E2F-1 gene transfer inhibits MDM2 expression and efficiently induces apoptosis in MDM2-overexpressing tumor cells.
Neoplasms
Adenovirus-mediated gene therapy for experimental spinal cord tumors: tumoricidal efficacy and functional outcome.
Neoplasms
Adenovirus-mediated gene therapy in an experimental model of breast cancer metastatic to the brain.
Neoplasms
Adenovirus-mediated gene transfer to orthotopic hepatocellular carcinomas in athymic nude mice.
Neoplasms
Adenovirus-mediated interferon-beta gene therapy suppresses growth and metastasis of human prostate cancer in nude mice.
Neoplasms
Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer [seecomments]
Neoplasms
Adrenocortical-specific transgene expression directed by steroid hydroxylase gene promoters.
Neoplasms
Altered epigenetic patterning leading to replicative senescence and reduced longevity. A role of a novel SNF2 factor, PASG.
Neoplasms
An in vitro immuno-enzymatic assay of tumor antigens in the mouse with beta-galactosidase.
Neoplasms
An intracellular anti-erbB-2 single-chain antibody is specifically cytotoxic to human breast carcinoma cells overexpressing erbB-2.
Neoplasms
Anti-tumor activity of cytotoxic T lymphocytes elicited with recombinant and synthetic forms of a model tumor-associated antigen.
Neoplasms
Anti-tumor immunity against CT26 colon tumor in mice immunized with plasmid DNA encoding beta-galactosidase fused to an envelope protein of endogenous retrovirus.
Neoplasms
Antigen-specific tumor vaccine efficacy in vivo against prostate cancer with low class I MHC requires competent class II MHC.
Neoplasms
Antitumor effect of in vivo somatostatin receptor subtype 2 gene transfer in primary and metastatic pancreatic cancer models.
Neoplasms
Antitumoral efficacy of DNA nanoparticles in murine models of lung cancer and pulmonary metastasis.
Neoplasms
B cell tumor vaccine enhanced by covalent attachment of immunoglobulin to surface proteins on dendritic cells.
Neoplasms
Beta galactosidase mediated bio-enzymatically synthesized nano-gold with aggrandized cytotoxic potential against pathogenic bacteria and cancer cells.
Neoplasms
Beta-galactosidase gene transfer to human malignant glioma in vivo using replication-deficient retroviruses and adenoviruses.
Neoplasms
Beta-N-acetylglucosaminidase, beta-galactosidase, and alpha-mannosidase activities in human female genital cancer.
Neoplasms
BGLAP is expressed in pancreatic cancer cells and increases their growth and invasion.
Neoplasms
Brain tumor therapy by combined vaccination and antisense oligonucleotide delivery with nanoparticles.
Neoplasms
Cancer gene therapy using tumor cells infected with recombinant vaccinia virus expressing GM-CSF.
Neoplasms
Cancer-inducible transgene expression by the Grp94 promoter: spontaneous activation in tumors of various origins and cancer-associated macrophages.
Neoplasms
Cell-specific, multidrug delivery system using streptavidin-protein A fusion protein.
Neoplasms
Characteristics of a potent tumor vaccine-induced secondary anti-tumor T cell response.
Neoplasms
Characterization of Senescence of Human Adipose-Derived Stem Cells After Long-Term Expansion.
Neoplasms
Characterization of spontaneous metastasis in an aggressive breast carcinoma model using flow cytometry.
Neoplasms
Chemopreventive agents induce a senescence-like phenotype in rat mammary tumours.
Neoplasms
Chronic in vitro exposure to 3'-azido-2', 3'-dideoxythymidine induces senescence and apoptosis and reduces tumorigenicity of metastatic mouse mammary tumor cells.
Neoplasms
Chronic p27Kip1 Induction by Dexamethasone Causes Senescence Phenotype and Permanent Cell Cycle Blockade in Lung Adenocarcinoma Cells Over-expressing Glucocorticoid Receptor.
Neoplasms
Clonal dominance detected in metastases but not primary tumors of retrovirally marked human breast carcinoma injected into nude mice.
Neoplasms
Co-delivery of T helper 1-biasing cytokine genes enhances the efficacy of gene gun immunization of mice: studies with the model tumor antigen beta-galactosidase and the BALB/c Meth A p53 tumor-specific antigen.
Neoplasms
Co-expression of granulocyte-macrophage colony-stimulating factor with antigen enhances humoral and tumor immunity after DNA vaccination.
Neoplasms
Combined intratumoral injection of bone marrow-derived dendritic cells and systemic chemotherapy to treat pre-existing murine tumors.
Neoplasms
Comparative analyses of transgene delivery and expression in tumors inoculated with a replication-conditional or -defective viral vector.
Neoplasms
Comparative analysis of antigen loading strategies of dendritic cells for tumor immunotherapy.
Neoplasms
Comparative studies between nude and scid mice on the growth and metastatic behavior of xenografted human tumors.
Neoplasms
Comparison of promoter strengths on gene delivery into mammalian brain cells using AAV vectors.
Neoplasms
Composition of PLGA and PEI/DNA nanoparticles improves ultrasound-mediated gene delivery in solid tumors in vivo.
Neoplasms
Conjugates of COL-1 monoclonal antibody and beta-D-galactosidase can specifically kill tumor cells by generation of 5-fluorouridine from the prodrug beta-D-galactosyl-5-fluorouridine.
Neoplasms
Construction of an EGF receptor-mediated histone H1(0)-based gene delivery system.
Neoplasms
Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence.
Neoplasms
Correlative fine specificity of several Thomsen-Friedenreich disaccharide-binding proteins with an effect on tumor cell proliferation.
Neoplasms
Costimulation enhances the active immunotherapy effect of recombinant anticancer vaccines.
Neoplasms
Cytokine enhancement of DNA immunization leads to effective treatment of established pulmonary metastases.
Neoplasms
Cytologic detection of cervical and endometrial carcinoma with other genital tract involvement.
Neoplasms
Cytological and biochemical methods for the characterization of in vitro cultured cells.
Neoplasms
Decreased metastatic spread in mice homozygous for a null allele of the cystatin C protease inhibitor gene.
Neoplasms
Dendritic cells genetically modified with an adenovirus vector encoding the cDNA for a model antigen induce protective and therapeutic antitumor immunity.
Neoplasms
Dendritic cells retrovirally transduced with a model antigen gene are therapeutically effective against established pulmonary metastases.
Neoplasms
Development of pyrrolo[2,1-c][1,4]benzodiazepine beta-galactoside prodrugs for selective therapy of cancer by ADEPT and PMT.
Neoplasms
Diagnostic value of determinations of lysosomal hydrolases in CSF of patients with neurological diseases.
Neoplasms
Direct evidence of the importance of stromal urokinase plasminogen activator (uPA) in the growth of an experimental human breast cancer using a combined uPA gene-disrupted and immunodeficient xenograft model.
Neoplasms
Direct in vivo gene transfer and expression in malignant cells using adenovirus vectors.
Neoplasms
Disabled infectious single cycle herpes simplex virus (DISC-HSV) is a candidate vector system for gene delivery/expression of GM-CSF in human prostate cancer therapy.
Neoplasms
Discovery of new beta-D-galactosidase inhibitors via pharmacophore modeling and QSAR analysis followed by in silico screening.
Neoplasms
Dissection of tumour and host cells from target organs of metastasis for testing gene expression directly ex vivo.
Neoplasms
Distinct roles of adenovirus vector-transduced dendritic cells, myoblasts, and endothelial cells in mediating an immune response against a transgene product.
Neoplasms
DNA loop sequence as the determinant for chiral supramolecular compound G-quadruplex selectivity.
Neoplasms
Dose-dependent transduction of vesicular stomatitis virus G protein-pseudotyped retrovirus vector into human solid tumor cell lines and murine fibroblasts.
Neoplasms
Early characterization of a novel metastatic disease model of murine neuroblastoma.
Neoplasms
Effect of differences in cancer cells and tumor growth sites on recruiting bone marrow-derived endothelial cells and myofibroblasts in cancer-induced stroma.
Neoplasms
Effect of mutant IkappaB on cytokine-induced activation of NF-kappaB in cultured human RPE cells.
Neoplasms
Efficacy of multiple administrations of a recombinant adenovirus expressing wild-type p53 in an immune-competent mouse tumor model.
Neoplasms
Efficacy of p53 adenovirus-mediated gene therapy against human breast cancer xenografts.
Neoplasms
Efficient adenovirus-mediated gene transfer into human blood monocyte-derived macrophages.
Neoplasms
Efficient and cancer-selective gene transfer to hepatocellular carcinoma in a rat using adenovirus vector with iodized oil esters.
Neoplasms
Empirical advantages of adeno associated viral vectors in vivo gene therapy for arthritis.
Neoplasms
Enhanced efficiency and specificity of ovarian cancer gene therapy in rats with a novel nonviral gene delivery system (GE7) via intraovarian artery perfusion approach.
Neoplasms
Enhanced thermal stability of lysosomal beta-D-galactosidase in parenchymal cells of tumour bearing mice.
Neoplasms
Enhancing efficacy of recombinant anticancer vaccines with prime/boost regimens that use two different vectors.
Neoplasms
Enzyme activity profiles in mouse teratocarcinomas. A quantitative ultramicroscale analysis.
Neoplasms
Enzyme-linked immunosorbent assay for the quantification of actinomycin D using beta-D-galactosidase as a label.
Neoplasms
Ephemerally expressed wild-type and mutant steroid hormone receptors are equally able to influence expression of transient or resident templates.
Neoplasms
Epidermal growth factor receptor as a genetic therapy target for carcinoma cell radiosensitization.
Neoplasms
Eradication of pre-established lymphoma using herpes simplex virus amplicon vectors.
Neoplasms
Evaluation and optimization of different cationic liposome formulations for in vivo gene transfer.
Neoplasms
Evaluation of a nude mouse tumor model using beta-galactosidase-expressing melanoma cells.
Neoplasms
Evaluation of gas-filled microparticles and sonoporation as gene delivery system: feasibility study in rodent tumor models.
Neoplasms
Exploiting the lacZ reporter gene for quantitative analysis of disseminated tumor growth within the brain: use of the lacZ gene product as a tumor antigen, for evaluation of antigenic modulation, and to facilitate image analysis of tumor growth in situ.
Neoplasms
Expression and regulation of Escherichia coli lacZ gene fusions in mammalian cells.
Neoplasms
Expression of transgenes in normal and neoplastic anterior pituitary cells using recombinant adenoviruses: long term expression, cell cycle dependency, and effects on hormone secretion.
Neoplasms
Fibroblast growth factor 2 restrains Ras-driven proliferation of malignant cells by triggering RhoA-mediated senescence.
Neoplasms
Fibroblast growth factor 4 transfection of MCF-7 cells produces cell lines that are tumorigenic and metastatic in ovariectomized or tamoxifen-treated athymic nude mice.
Neoplasms
Folate receptor mediated DNA delivery into tumor cells: potosomal disruption results in enhanced gene expression.
Neoplasms
Foreign antigenic peptides delivered to the tumor as targets of cytotoxic T cells.
Neoplasms
Fractional laser exposure induces neutrophil infiltration (N1 phenotype) into the tumor and stimulates systemic anti-tumor immune response.
Neoplasms
Functional analysis of the steroid hormone control region of mouse mammary tumor virus.
Neoplasms
G-quadruplex stabilizer 3,6-bis(1-methyl-4-vinylpyridinium)carbazole diiodide induces accelerated senescence and inhibits tumorigenic properties in cancer cells.
Neoplasms
Galactosyltransferase activity in metastasizing and nonmetastasizing rat mammary carcinomas and its possible relationship with tumor cell surface antigen shedding.
Neoplasms
Gemcitabine synergistically enhances the effect of adenovirus gene therapy through activation of the CMV promoter in pancreatic cancer cells.
Neoplasms
Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line.
Neoplasms
Gene delivery using a receptor-mediated gene transfer system targeted to hepatocellular carcinoma cells.
Neoplasms
Gene expression in intrahepatic tumors through DNA recombination by a replication-activated adenovirus vector.
Neoplasms
Gene therapy of human bladder cancer with adenovirus-mediated antisense basic fibroblast growth factor.
Neoplasms
Gene therapy of rat medullary thyroid cancer by naked nitric oxide synthase II DNA injection.
Neoplasms
Gene therapy utilizing the Cre/loxP system selectively suppresses tumor growth of disseminated carcinoembryonic antigen-producing cancer cells.
Neoplasms
Gene transfer of pigment epithelium-derived factor suppresses tumor growth and angiogenesis in a hepatoblastoma xenograft model.
Neoplasms
Gene transfer of the vascular endothelial growth factor receptor flt-1 suppresses pulmonary metastasis associated with lung growth.
Neoplasms
Gene-directed enzyme prodrug therapy with a mustard prodrug/carboxypeptidase G2 combination.
Neoplasms
Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas.
Neoplasms
Glycosidases of Ehrlich ascites tumor cells and ascitic fluid--purification and substrate specificity of alpha-N-acetylgalactosaminidase and alpha-galactosidase: comparison with coffee bean alpha-galactosidase.
Neoplasms
Growth factor-mediated interaction between tumor cells and stromal fibroblasts in an experimental model of human small-cell lung cancer.
Neoplasms
Heat-shock enhanced reactivation of a UV-damaged reporter gene in human cells involves the transcription coupled DNA repair pathway.
Neoplasms
High levels of gene transduction in human lung tumors following intralesional injection of recombinant adenovirus.
Neoplasms
Highly attenuated modified vaccinia virus Ankara (MVA) as an effective recombinant vector: a murine tumor model.
Neoplasms
Histochemical demonstration of different types of poly-N-acetyllactosamine structures in human thyroid neoplasms using lectins and endo-beta-galactosidase digestion.
Neoplasms
HoxD10 gene delivery using adenovirus/adeno-associate hybrid virus inhibits the proliferation and tumorigenicity of GH4 pituitary lactotrope tumor cells.
Neoplasms
Identification of a Kb-restricted CTL epitope of beta-galactosidase: potential use in development of immunization protocols for "self" antigens.
Neoplasms
IFI16 inhibits tumorigenicity and cell proliferation of bone and cartilage tumor cells.
Neoplasms
IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death.
Neoplasms
IL-12 is an effective adjuvant to recombinant vaccinia virus-based tumor vaccines: enhancement by simultaneous B7-1 expression.
Neoplasms
IL-2 enhances the function of recombinant poxvirus-based vaccines in the treatment of established pulmonary metastases.
Neoplasms
Imaging beta-galactosidase activity in human tumor xenografts and transgenic mice using a chemiluminescent substrate.
Neoplasms
Immuno-gene therapy with interferon-beta before surgical debulking delays recurrence and improves survival in a murine model of malignant mesothelioma.
Neoplasms
Immunopharmacological and antitumor effects of second-generation immunomodulatory oligonucleotides containing synthetic CpR motifs.
Neoplasms
In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats.
Neoplasms
In vitro and in vivo herpetic vector-mediated gene transfer in the pituitary gland: impact on hormone secretion.
Neoplasms
In vitro and in vivo transfection of plasmid DNA in the Dunning prostate tumor R3327-AT1 is enhanced by focused ultrasound.
Neoplasms
In vivo cytokine gene therapy of human tumor xenografts in SCID mice by liposome-mediated DNA delivery.
Neoplasms
In vivo cytotoxicity of ovarian cancer cells through tumor-selective expression of the BAX gene.
Neoplasms
In vivo gene transfer of pigment epithelium-derived factor inhibits tumor growth in syngeneic murine models of thoracic malignancies.
Neoplasms
In vivo interleukin-2 gene therapy of established tumors with herpes simplex amplicon vectors.
Neoplasms
In vivo marking of spontaneous or vaccine-induced fibrosarcomas in the domestic house cat, using an adenoviral vector containing a bifunctional fusion protein, GAL-TEK.
Neoplasms
In vivo selective gene expression and therapy mediated by adenoviral vectors for human carcinoembryonic antigen-producing gastric carcinoma.
Neoplasms
In vivo studies of adenovirus-mediated p53 gene therapy for cis-platinum-resistant human ovarian tumor xenografts.
Neoplasms
In vivo suppression of osteosarcoma pulmonary metastasis with intravenous osteocalcin promoter-based toxic gene therapy.
Neoplasms
In vivo transfer of bacterial marker genes results in differing levels of gene expression and tumor progression in immunocompetent and immunodeficient mice.
Neoplasms
Increased activity of lysosomal enzymes in the peritoneal fluid of patients with gynecologic cancers and pelvic inflammatory disease.
Neoplasms
Increased activity of lysosomal glycohydrolases in glioma tissue and surrounding areas from human brain.
Neoplasms
Increased manganese superoxide dismutase (SOD-2) is part of the mechanism for prostate tumor suppression by Mac25/insulin-like growth factor binding-protein-related protein-1.
Neoplasms
Increased tumor localization and reduced immune response to adenoviral vector formulated with the liposome DDAB/DOPE.
Neoplasms
Induced senescence in HeLa cervical carcinoma cells containing elevated telomerase activity and extended telomeres.
Neoplasms
Induction of orthotopic rat adrenomedullary neoplasia by intraadrenal pheochromocytoma cell transplantation.
Neoplasms
Induction of senescent-like growth arrest as a new target in anticancer treatment.
Neoplasms
Influence of gene-modified (IL-7, IL-4, and B7) tumor cell vaccines on tumor antigen presentation.
Neoplasms
Inhibition of human P-glycoprotein transport and substrate binding using a galantamine dimer.
Neoplasms
Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor.
Neoplasms
Inhibition of oncogenic K-ras signaling by aerosolized gene delivery in a mouse model of human lung cancer.
Neoplasms
Interleukin-7/B7.1-encoding adenoviruses induce rejection of transplanted but not nontransplanted tumors.
Neoplasms
Intra-pinna anti-tumor vaccination with self-replicating infectious RNA or with DNA encoding a model tumor antigen and a cytokine.
Neoplasms
Intraarterial delivery of adenovirus vectors and liposome-DNA complexes to experimental brain neoplasms.
Neoplasms
Intracerebral adenovirus-mediated p53 tumor suppressor gene therapy for experimental human glioma.
Neoplasms
Intratracheal injection of manganese superoxide dismutase (MnSOD) plasmid/liposomes protects normal lung but not orthotopic tumors from irradiation.
Neoplasms
Intravesical liposome-mediated interleukin-2 gene therapy in orthotopic murine bladder cancer model.
Neoplasms
Invasiveness by lacZ transfected non-small-cell lung cancer cells into human bronchial tissues in vitro.
Neoplasms
Ionizing radiation increases adenovirus uptake and improves transgene expression in intrahepatic colon cancer xenografts.
Neoplasms
Isolated limb perfusion in the sarcoma-bearing rat: a novel preclinical gene delivery system.
Neoplasms
Lithotripter shock waves with cavitation nucleation agents produce tumor growth reduction and gene transfer in vivo.
Neoplasms
Live attenuated measles virus induces regression of human lymphoma xenografts in immunodeficient mice.
Neoplasms
Localization of iodine-125-mIP-Des-Met14-bombesin (7-13)NH2 in ovarian carcinoma induced to express the gastrin releasing peptide receptor by adenoviral vector-mediated gene transfer.
Neoplasms
Long-term humoral and cellular immunity induced by a single immunization with replication-defective adenovirus recombinant vector.
Neoplasms
Lymphatic endothelial tumors induced by intraperitoneal injection of incomplete Freund's adjuvant.
Neoplasms
Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells.
Neoplasms
Macrophage activation by trehalose dimycolate requirement for an expression signal in vitro for antitumoral activity; biochemical markers distinguishing primed and fully activated macrophages.
Neoplasms
MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumors.
Neoplasms
Measurement of tumor load and distribution in a model of cancer-induced osteolysis: a necessary precaution when testing novel anti-resorptive therapies.
Neoplasms
MicroRNA changes in human arterial endothelial cells with senescence: relation to apoptosis, eNOS and inflammation.
Neoplasms
Modification to the capsid of the adenovirus vector that enhances dendritic cell infection and transgene-specific cellular immune responses.
Neoplasms
Modulation of beta-galactosidase activity in peritoneal macrophages from C57B1 mice after exposure to Proprionibacterium acnes.
Neoplasms
Modulation of gene expression after replication-deficient, recombinant adenovirus-mediated gene transfer by the product of a second adenovirus vector.
Neoplasms
Modulation of osteoclast function by adenovirus vector-induced epidermal growth factor receptor.
Neoplasms
Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo.
Neoplasms
Non-invasive in vivo optical imaging of the lacZ and luc gene expression in mice.
Neoplasms
Noninvasive method of immortalized neural stem-like cell transplantation in an experimental model of Huntington's disease.
Neoplasms
Nonviral in vivo gene delivery into tumors using a novel low volume jet-injection technology.
Neoplasms
Notch-induced mammary tumorigenesis does not involve the lobule-limited epithelial progenitor.
Neoplasms
Nuclear localization signals also mediate the outward movement of proteins from the nucleus.
Neoplasms
Overexpression of the p21 sdi1 gene induces senescence-like state in human cancer cells: implication for senescence-directed molecular therapy for cancer.
Neoplasms
Overexpression of tissue inhibitor of metalloproteinases-2 retroviral-mediated gene transfer in vivo inhibits tumor growth and invasion.
Neoplasms
Oxygen sensitivity of reporter genes: implications for preclinical imaging of tumor hypoxia.
Neoplasms
p53 alone or in combination with antisense cyclin D1 induces apoptosis and reduces tumor size in human melanoma.
Neoplasms
p53 dependent cell-cycle arrest triggered by chemotherapy in xenografted breast tumors.
Neoplasms
p53 gene therapy in a rat model of hepatocellular carcinoma: intra-arterial delivery of a recombinant adenovirus.
Neoplasms
Pan-Cancer Analyses Reveal Prognostic Value of Osteomimicry Across 20 Solid Cancer Types.
Neoplasms
Persistent, antigen-specific, therapeutic antitumor immunity by dendritic cells genetically modified with an adenoviral vector to express a model tumor antigen.
Neoplasms
Phase I study of a recombinant adenovirus-mediated gene transfer in lung cancer patients.
Neoplasms
Phase I trial of recombinant adenovirus gene transfer in lung cancer. Longitudinal study of the immune responses to transgene and viral products.
Neoplasms
Plasma Escherichia coli beta-galactosidase as a marker of tumor burden and response to experimental anti-neoplastic therapy in nude mice xenografted with lacZ transduced human tumor cells.
Neoplasms
Polycations and cationic lipids enhance adenovirus transduction and transgene expression in tumor cells.
Neoplasms
Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application.
Neoplasms
Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo.
Neoplasms
Preclinical evaluation of "whole" cell vaccines for prophylaxis and therapy using a disabled infectious single cycle-herpes simplex virus vector to transduce cytokine genes.
Neoplasms
Preferential gene transfer to BBN-induced rat bladder tumor by simple instillation of adenoviral vector.
Neoplasms
Pretreatment with protease is a useful experimental strategy for enhancing adenovirus-mediated cancer gene therapy.
Neoplasms
Primary graft nonfunction and Kupffer cell activation after liver transplantation from non-heart-beating donors in pigs.
Neoplasms
Priming for T-cell-mediated rejection of established tumors by cutaneous DNA immunization.
Neoplasms
Principal component analysis of quantitative trait loci for immune response to adenovirus in mice.
Neoplasms
Promoter function of different lengths of the murine luteinizing hormone receptor gene 5'-flanking region in transfected gonadal cells and in transgenic mice.
Neoplasms
Proteasome inhibitors reduce luciferase and beta-galactosidase activity in tissue culture cells.
Neoplasms
Protein-specific cytotoxic T lymphocytes. Recognition of transfectants expressing intracellular, membrane-associated or secreted forms of beta-galactosidase.
Neoplasms
Purified herpes simplex thymidine kinase Retrovector particles. I. In vitro characterization, in situ transduction efficiency, and histopathological analyses of gene therapy-treated brain tumors.
Neoplasms
Quantitative and qualitative characterization of human cancer-associated serum glycoprotein antigens expressing fucosyl or sialyl-fucosyl type 2 chain polylactosamine.
Neoplasms
Quantitative demonstration of spontaneous metastasis by MCF-7 human breast cancer cells cotransfected with fibroblast growth factor 4 and LacZ.
Neoplasms
Radiation-mediated up-regulation of gene expression from replication-defective adenoviral vectors: implications for sodium iodide symporter gene therapy.
Neoplasms
Rapid production of interleukin-2-secreting tumor cells by herpes simplex virus-mediated gene transfer: implications for autologous vaccine production.
Neoplasms
Recombinant adeno-associated virus for the generation of autologous, gene-modified tumor vaccines: evidence for a high transduction efficiency into primary epithelial cancer cells.
Neoplasms
Recombinant adenovirus shedding after intratumoral gene transfer in lung cancer patients.
Neoplasms
Regional delivery and selective expression of a high-activity yeast cytosine deaminase in an intrahepatic colon cancer model.
Neoplasms
Relation of human blood-groups MN to cancer cell surface antigens and to receptors for oncogenic viruses.
Neoplasms
Replication-defective recombinant Semliki Forest virus encoding GM-CSF as a vector system for rapid and facile generation of autologous human tumor cell vaccines.
Neoplasms
Reporter gene assay demonstrates functional differences in estrogen receptor activity in purified breast cancer cells: a pilot study.
Neoplasms
Runx2 deficiency and defective subnuclear targeting bypass senescence to promote immortalization and tumorigenic potential.
Neoplasms
Safety, pharmacokinetics and biodistribution studies of a beta-galactoside prodrug of doxorubicin for improvement of tumor selective chemotherapy.
Neoplasms
Secretion of extracellular superoxide dismutase from muscle transduced with recombinant adenovirus inhibits the growth of B16 melanomas in mice.
Neoplasms
Selective astrocytic transgene expression in vitro and in vivo from the GFAP promoter in a HSV RL1 null mutant vector--potential glioblastoma targeting.
Neoplasms
Selective gene expression in hepatic tumor with trans-arterial delivery of DNA/liposome/transferrin complex.
Neoplasms
Selective uptake of viral and monocrystalline particles delivered intra-arterially to experimental brain neoplasms.
Neoplasms
Sequence divergence yet conserved physical characteristics among the E4 proteins of cutaneous human papillomaviruses.
Neoplasms
Simple enzyme immunoassay methods for recombinant human tumor necrosis factor alpha and its antibodies using a bacterial cell wall carrier.
Neoplasms
Simultaneous expression of keratan sulphate epitope (a sulphated poly-N-acetyllactosamine) and blood group ABH antigens in papillary carcinomas of the human thyroid gland.
Neoplasms
Simultaneous radiolabel, genetic tagging and proliferation assays to study the organ distribution and fate of metastatic cells.
Neoplasms
Stable integration of an mdx skeletal muscle cell line into dystrophic (mdx) skeletal muscle: evidence for stem cell status.
Neoplasms
Stereotactic delivery of a recombinant adenovirus into a C6 glioma cell line in a rat brain tumor model.
Neoplasms
Studies of lectin binding to the human cervix uteri: II. Cervical intraepithelial neoplasia and invasive squamous carcinoma.
Neoplasms
Studies of the route of administration and role of conditioning with radiation on unrelated allogeneic mismatched mesenchymal stem cell engraftment in a nonhuman primate model.
Neoplasms
Studies on the kinetics of glycosidases from chemically-induced rat colonic tumours and normal rat colon.
Neoplasms
Studies on variations of glycoproteins and lysosomal hydrolases in human uterine cervical carcinoma.
Neoplasms
Successful in vivo tumor targeting of prostate-specific membrane antigen with a highly efficient J591/PEI/DNA molecular conjugate.
Neoplasms
Suppression of human colon tumor growth by adenoviral vector-mediated NK4 expression in an athymic mouse model.
Neoplasms
Suppression of malignant growth potentials of v-Src-transformed human gallbladder epithelial cells by adenovirus-mediated dominant negative H-Ras.
Neoplasms
Switching on and off transgene expression within lactotrophic cells in the anterior pituitary gland in vivo.
Neoplasms
Syn3 provides high levels of intravesical adenoviral-mediated gene transfer for gene therapy of genetically altered urothelium and superficial bladder cancer.
Neoplasms
Synthesis and characterization of a new bioactivated paramagnetic gadolinium(III) complex [Gd(DOTA-FPG)(H2O)] for tracing gene expression.
Neoplasms
Synthesis and enzyme-specific activation of carbohydrate-geldanamycin conjugates with potent anticancer activity.
Neoplasms
Synthesis and evaluation of 18F- and 11C-labeled phenyl-galactopyranosides as potential probes for in vivo visualization of LacZ gene expression using positron emission tomography.
Neoplasms
Systemic gene therapy with p53 reduces growth and metastases of a malignant human breast cancer in nude mice.
Neoplasms
Targeted gene transfer to hepatocellular carcinoma cells in vitro using a novel monoclonal antibody-based gene delivery system.
Neoplasms
Targeting of the mitochondrion by dinuclear thiolato-bridged arene ruthenium complexes in cancer cells and in the apicomplexan parasite Neospora caninum.
Neoplasms
Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins.
Neoplasms
The activity of serum beta-galactosidase in colon cancer patients with a history of alcohol and nicotine dependence: preliminary data.
Neoplasms
The dose dependence of glucocorticoid-inducible gene expression results from changes in the number of transcriptionally active templates.
Neoplasms
The hemagglutinin-neuraminidase gene of Newcastle Disease Virus: a powerful molecular adjuvant for DNA anti-tumor vaccination.
Neoplasms
The hepatitis C virus internal ribosome entry site facilitates efficient protein synthesis in blood vessel endothelium during tumour angiogenesis.
Neoplasms
The influence of oral tumor cell proliferation activity and membrane potential on the transfection efficiency of a cationic liposome.
Neoplasms
The use of laser scanning cytometry to assess depth of penetration of adenovirus p53 gene therapy in human xenograft biopsies.
Neoplasms
Therapeutic immune response induced by electrofusion of dendritic and tumor cells.
Neoplasms
Trafficking of tumor peptide-specific cytotoxic T lymphocytes into the tumor microcirculation.
Neoplasms
Transfection of rat ovarian surface epithelium with erb-B2/neu induces transformed phenotypes in vitro and the tumorigenic phenotype in vivo.
Neoplasms
Transgene expression in malignant glioma using a replication-defective adenoviral vector containing the Egr-1 promoter: activation by ionizing radiation or uptake of radioactive iododeoxyuridine.
Neoplasms
Transgenic expression of 15-lipoxygenase 2 (15-LOX2) in mouse prostate leads to hyperplasia and cell senescence.
Neoplasms
Treatment with hydroxyurea and tyrphostin-1 significantly improves the transduction efficiency of recombinant adeno-associated viruses in human cancer cells.
Neoplasms
Tumor formation following murine neural precursor cell transplantation in a rat peripheral nerve injury model.
Neoplasms
Tumor growth inhibition elicited by different vaccines and correlation with antigen specific cytotoxic T-cell frequencies determined by intracellular interferon-gamma staining.
Neoplasms
Tumor growth reduction and DNA transfer by cavitation-enhanced high-intensity focused ultrasound in vivo.
Neoplasms
Tumor necrosis factor inhibitor gene transfer ameliorates lung graft ischemia-reperfusion injury.
Neoplasms
Tumor necrosis factor-alpha inhibits hTERT gene expression in human myeloid normal and leukemic cells.
Neoplasms
Tumor suppression without differentiation or apoptosis by antisense cyclin D1 gene transfer in K1735 melanoma involves induction of p53, p21WAF1 and superoxide dismutases.
Neoplasms
Tumor-induced interleukin-10 inhibits type 1 immune responses directed at a tumor antigen as well as a non-tumor antigen present at the tumor site.
Neoplasms
Tumor-specific gene delivery mediated by a novel peptide-polyethylenimine-DNA polyplex targeting aminopeptidase N/CD13.
Neoplasms
Tumor-targeted gene delivery using poly(ethylene glycol)-modified gelatin nanoparticles: in vitro and in vivo studies.
Neoplasms
Unique domain functions of p63 isotypes that differentially regulate distinct aspects of epidermal homeostasis.
Neoplasms
Up-regulation of vascular endothelial growth factor expression in a rat glioma is conferred by two distinct hypoxia-driven mechanisms.
Neoplasms
Use of recombinant herpes simplex virus type 1 vectors for gene transfer into tumour and normal anterior pituitary cells.
Neoplasms
VEGF(165), but not VEGF(189), stimulates vasculogenesis and bone marrow cell migration into Ewing's sarcoma tumors in vivo.
Neoplasms
[Correlation between anti-tumor effect and delayed hypersensitivity induced by topically applied OK-432 with histological findings]
Neoplasms
[Detection and distribution of the hydrolytic enzymes beta-D-glucuronidase, beta-D-galactosidase, beta-D-glucosidase and arylsulfatase in intracranial tumors]
Neoplasms
[Effect of gynecologic cancer sera on functions of monocyte from healthy volunteers]
Neoplasms
[Establishment of mouse melanoma model expressing beta-galactosidase and its application in the research of DNA vaccines against tumor]
Neoplasms
[Gene therapy of a model of glioblastoma in rats using adenovirus vector encoding the HSVtk gene]
Neoplasms
[Gene therapy of cerebral glioblastoma by adenovirus vector. Experimental model in the rat]
Neoplasms
[Study of GE7-transferring system mediated beta-galactosidase gene transfer in a rat model of ovarian tumor by intraarterial route]
Neoplasms
[Synthesis of GnRH analogs and their application in targeted gene delivery systems].
Nephritis
Gene transfer into inflamed glomeruli using macrophages transfected with adenovirus.
Nephritis, Hereditary
Adenovirus-mediated gene transfer into kidney glomeruli using an ex vivo and in vivo kidney perfusion system - first steps towards gene therapy of Alport syndrome.
Nephrolithiasis
Possible biphasic changes of free radicals in ethylene glycol-induced nephrolithiasis in rats.
Nervous System Diseases
Diagnosis of feline GM1 gangliosidosis by enzyme assay of cultured conjunctival cells.
Nervous System Diseases
GM1-gangliosidosis (genetic beta-galactosidase deficiency): identification of four mutations in different clinical phenotypes among Japanese patients.
Nervous System Diseases
Molecular heterogeneity in human beta-galactosidase and neuraminidase deficiency.
Neurilemmoma
[Demonstration and distribution of the enzymes: beta-D-glucuronidase, beta-D-galactosidase, beta-D-glucosidase, and arylsulfatase in neurinomas.]
Neuroblastoma
A system, using neural cell lines, to characterize HSV-1 vectors containing genes which affect neuronal physiology, or neuronal promoters.
Neuroblastoma
Degree of polymerization (DP) of polysialic acid (polySia) on neural cell adhesion molecules (N-CAMS): development and application of a new strategy to accurately determine the DP of polySia chains on N-CAMS.
Neuroblastoma
Early characterization of a novel metastatic disease model of murine neuroblastoma.
Neuroblastoma
Ellagic acid reveals promising anti-aging effects against d-galactose-induced aging on human neuroblastoma cell line, SH-SY5Y: A mechanistic study.
Neuroblastoma
Inactivation of GM1-ganglioside beta-galactosidase by a specific inhibitor: a model for ganglioside storage disease.
Neuroblastoma
Poly-N-acetyllactosamine glycans of cellular glycoproteins: predominance of linear chains in mouse neuroblastoma and rat pheochromocytoma cell lines.
Neuroblastoma
Retinoic acid stimulates alpha-CAMKII gene expression in PC12 cells at a distinct transcription initiation site.
Neuroblastoma
Retroviral transfer of the beta-nerve growth factor gene into murine neuroectodermal tumor cells modulates cell proliferation rate, neurite formation, and NGF binding site expression.
Neurodegenerative Diseases
Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis.
Neurodegenerative Diseases
GM1 gangliosidosis and Morquio B disease: expression analysis of missense mutations affecting the catalytic site of acid beta-galactosidase.
Neurodegenerative Diseases
GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.
Neurodegenerative Diseases
Inheritance of lysosomal acid beta-galactosidase activity and gangliosides in crosses of DBA/2J and knockout mice.
Neurodegenerative Diseases
Inhibition of human P-glycoprotein transport and substrate binding using a galantamine dimer.
Neurodegenerative Diseases
Molecular consequences of the pathogenic mutation in feline GM1 gangliosidosis.
Neurodegenerative Diseases
TDP-43 is a developmentally regulated protein essential for early embryonic development.
Neurologic Manifestations
Neurological manifestations of knockout mice with beta-galactosidase deficiency.
Nevus, Pigmented
Absence of senescence-associated beta-galactosidase activity in human melanocytic nevi in vivo.
Nevus, Pigmented
Comment on "Absence of senescence-associated beta-galactosidase activity in human melanocytic nevi in vivo".
Newcastle Disease
Resistance of native, oligomeric envelope on simian immunodeficiency virus to digestion by glycosidases.
Niemann-Pick Diseases
Electron microscopic examination of skin and conjunctival biopsy specimens in neuronal storage diseases.
Niemann-Pick Diseases
Lactosyl ceramidosis: deficient activity of neutral beta-galactosidase in liver and cultivated fibroblasts?
Non-alcoholic Fatty Liver Disease
Glycosylphosphatidylinositol-specific phospholipase d in nonalcoholic Fatty liver disease: a preliminary study.
Obesity
Analysis of osteocalcin as a candidate gene for type 2 diabetes (T2D) and intermediate traits in Caucasians and African Americans.
Onchocerciasis
Molecular cloning and characterization of recombinant parasite antigens for immunodiagnosis of onchocerciasis.
Osteoarthritis
Transplantation of transduced chondrocytes protects articular cartilage from interleukin 1-induced extracellular matrix degradation.
Osteoarthritis, Knee
Correlation between senescence-associated beta-galactosidase expression in articular cartilage and disease severity of patients with knee osteoarthritis.
Osteochondrodysplasias
Juvenile neurogenic muscle atrophy with lysosomal enzyme deficiencies: new disease or variant of mucopolysaccharidosis?
Osteochondrodysplasias
Morquio-B disease, spondyloepiphyseal dysplasia associated with acid beta-galactosidase deficiency. Report of three cases in one family.
Osteochondrodysplasias
Spondyloepiphyseal dysplasia, corneal clouding, normal intelligence and acid beta-galactosidase deficiency.
Osteochondrodysplasias
[Ophthalmologic and roentgenologic findings in a rare case of mucopolysaccharidosis 4 B]
Osteolysis
Measurement of tumor load and distribution in a model of cancer-induced osteolysis: a necessary precaution when testing novel anti-resorptive therapies.
Osteonecrosis
A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group.
Osteoporosis
[Kcnq1ot1 promotes osteogenic differentiation and suppresses osteoclast differentiation].
Osteoporosis, Postmenopausal
Osteocalcin: genetic and physical mapping of the human gene BGLAP and its potential role in postmenopausal osteoporosis.
Osteoporosis, Postmenopausal
[Kcnq1ot1 promotes osteogenic differentiation and suppresses osteoclast differentiation].
Osteosarcoma
Network Pharmacology Integrated Molecular Docking Reveals the Antiosteosarcoma Mechanism of Biochanin A.
Ovarian Cysts
Increased activity of lysosomal enzymes in the peritoneal fluid of patients with gynecologic cancers and pelvic inflammatory disease.
Ovarian Cysts
Structural characterization of neutral oligosaccharides of human midcycle cervical mucin.
Ovarian Neoplasms
In vitro and in vivo adenovirus-mediated p53 and p16 tumor suppressor therapy in ovarian cancer.
Ovarian Neoplasms
Transient detection of beta-galactosidase activity in hematopoietic cells, following reinjection of retrovirally marked autologous blood progenitors in patients with breast or ovarian cancer receiving high-dose chemotherapy.
Ovarian Neoplasms
Uridine 5'-diphosphate-galactose:glycoprotein galactosyltransferase activity in the ovarian cancer patient.
Ovarian Neoplasms
Use of L-plastin promoter to develop an adenoviral system that confers transgene expression in ovarian cancer cells but not in normal mesothelial cells.
Ovarian Neoplasms
[In vitro experimental study of gene therapy for ovarian cancer with thymidine kinase gene of herpes simplex virus mediated by a non-viral GE7 delivery system]
Pancreatic Neoplasms
BGLAP is expressed in pancreatic cancer cells and increases their growth and invasion.
Pancreatitis
Effects of acute pancreatitis on hepatic secretion of lysosomal enzymes into bile and hepatic lysosomal fragility: protective effects of a new synthetic protease inhibitor, ONO 3307.
Pancreatitis
Serum beta-N-acetylglucosaminidase, beta-D-glucosidase, alpha-D-glucosidase, beta-D-fucosidase, alpha-L-fucosidase and beta-D-galactosidase levels in acute viral hepatitis, pancreatitis, myocardial infarction and breast cancer.
Pancreatitis
Treatment of Inflamed Pancreas with Enkephalin Encoding HSV-1 Recombinant Vector Reduces Inflammatory Damage and Behavioral Sequelae.
Pancreatitis, Chronic
BGLAP is expressed in pancreatic cancer cells and increases their growth and invasion.
Papilloma
Expression profile of senescence-associated beta-galactosidase and activation of telomerase in human ovarian surface epithelial cells undergoing immortalization.
Papilloma
Expression vector with DNA of bovine papilloma virus 1 for keratinocyte gene therapy.
Papilloma
Priming of cytotoxic T lymphocytes by five heat-aggregated antigens in vivo: conditions, efficiency, and relation to antibody responses.
Papilloma
Studies of the activities of lysosomal enzymes in serum and buccal pouch tissue of hamsters during 7,12-dimethylbenz[a]anthracene-induced carcinogenesis.
Papilloma
[Transcriptional inhibition of human papilloma virus in cervical carcinoma cells reactivates functions of the tumor suppressor p53]
Paratuberculosis
Expression of Escherichia coli beta-galactosidase in Mycobacterium bovis BCG using an expression system isolated from Mycobacterium paratuberculosis which induced humoral and cellular immune responses.
Parotitis
[The lysosomal hydrolase activity in the blood of patients with inflammatory processes in the parotid gland with surgical pathology of the organs of the abdominal cavity]
Pelvic Inflammatory Disease
Increased activity of lysosomal enzymes in the peritoneal fluid of patients with gynecologic cancers and pelvic inflammatory disease.
Periodontitis
Glycosidase activities in gingival crevicular fluid in subjects with adult periodontitis or gingivitis.
Periodontitis
Impairment of osteocalcin production in senescent periodontal ligament fibroblasts.
Peritonitis
Gene therapy utilizing the Cre/loxP system selectively suppresses tumor growth of disseminated carcinoembryonic antigen-producing cancer cells.
Peritonitis
Increased activity of lysosomal enzymes in the peritoneal fluid of bacterial peritonitis.
Persistent Infection
[Persistent infection of bacteriophage. 4. One-step growth of MS 2 phage and its extracellular excretion of beta-galactosidase in the two clones of E. coli Hfr Ci-1 and -n]
Pheochromocytoma
A system, using neural cell lines, to characterize HSV-1 vectors containing genes which affect neuronal physiology, or neuronal promoters.
Pheochromocytoma
Enhancement of beta-galactosidase gene expression in rat pheochromocytoma cells by exposure to extremely low frequency magnetic fields.
Pheochromocytoma
Induction of orthotopic rat adrenomedullary neoplasia by intraadrenal pheochromocytoma cell transplantation.
Pheochromocytoma
Myogenic conversion of mammalian fibroblasts induced by differentiating muscle cells.
Pheochromocytoma
Poly(N-acetyllactosaminyl) oligosaccharides in glycoproteins of PC12 pheochromocytoma cells and sympathetic neurons.
Pheochromocytoma
Poly-N-acetyllactosamine glycans of cellular glycoproteins: predominance of linear chains in mouse neuroblastoma and rat pheochromocytoma cell lines.
Pheochromocytoma
Retinoic acid stimulates alpha-CAMKII gene expression in PC12 cells at a distinct transcription initiation site.
Pheochromocytoma
Retroviral transfer of the beta-nerve growth factor gene into murine neuroectodermal tumor cells modulates cell proliferation rate, neurite formation, and NGF binding site expression.
Pheochromocytoma
Specific binding of glycosylated beta-galactosidase to rat clonal pheochromocytoma PC12h cells: effects of nerve growth factor and gangliosides.
Pituitary Neoplasms
In vitro and in vivo herpetic vector-mediated gene transfer in the pituitary gland: impact on hormone secretion.
Pituitary Neoplasms
Studies on in vivo gene transfer in pituitary tumors using herpes-derived and adenoviral vectors.
Pleural Effusion
Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury.
Pneumonia
Effects of bronchopulmonary inflammation induced by pseudomonas aeruginosa on adenovirus-mediated gene transfer to airway epithelial cells in mice.
Pneumonia
Gene therapy with lipopolysaccharide binding protein for gram-negative pneumonia: respiratory physiology.
Pneumonia
Improved survival in mice given systemic gene therapy in a gram negative pneumonia model.
Poliomyelitis
beta-Galactosidase containing a human immunodeficiency virus protease cleavage site is cleaved and inactivated by human immunodeficiency virus protease.
Polycystic Kidney, Autosomal Dominant
Functional defects in lysosomal enzymes in autosomal dominant polycystic kidney disease (ADPKD): abnormalities in synthesis, molecular processing, polarity, and secretion.
Pre-Eclampsia
Endoplasmic reticulum stress disrupts lysosomal homeostasis and induces blockade of autophagic flux in human trophoblasts.
Prolactinoma
Studies on in vivo gene transfer in pituitary tumors using herpes-derived and adenoviral vectors.
Prostatic Hyperplasia
Expression of senescence-associated beta-galactosidase in enlarged prostates from men with benign prostatic hyperplasia.
Prostatic Hyperplasia
Transgenic expression of 15-lipoxygenase 2 (15-LOX2) in mouse prostate leads to hyperplasia and cell senescence.
Prostatic Neoplasms
Adenovirus-mediated suicide-gene therapy using the herpes simplex virus thymidine kinase gene in cell and animal models of human prostate cancer: changes in tumour cell proliferative activity.
Prostatic Neoplasms
Alterations in PMS2, MSH2 and MLH1 expression in human prostate cancer.
Prostatic Neoplasms
Beta-galactosidase as a marker of HSP70 promoter induction in Dunning R3327 prostate carcinoma cells.
Prostatic Neoplasms
Demonstration of a rational strategy for human prostate cancer gene therapy.
Prostatic Neoplasms
Development of a high-efficiency method for gene marking of Dunning prostate cancer cell lines with the enzyme beta-galactosidase.
Prostatic Neoplasms
In vitro evaluation of a p53-expressing adenovirus as an anti-cancer drug.
Prostatic Neoplasms
Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence.
Prostatic Neoplasms
Tissue transglutaminase interacts with protein kinase A anchor protein 13 in prostate cancer.
Proteinuria
Changes in lysosome populations in the rat kidney cortex induced by passive Heymann glomerulonephritis.
Pseudorabies
A glycoprotein gX-beta-galactosidase fusion gene as insertional marker for rapid identification of pseudorabies virus mutants.
Pseudorabies
beta-Galactosidase expressing recombinant pseudorabies virus for light and electron microscopic study of transneuronally labeled CNS neurons.
Pseudorabies
Central autonomic control of the bone marrow: multisynaptic tract tracing by recombinant pseudorabies virus.
Pseudorabies
CNS cell groups projecting to the submandibular parasympathetic preganglionic neurons in the rat: a retrograde transneuronal viral cell body labeling study.
Pseudorabies
Dendritic morphology of cardiac related medullary neurons defined by circuit-specific infection by a recombinant pseudorabies virus expressing beta-galactosidase.
Pseudorabies
Expression of three recombinant proteins using baculovirus vectors in 23 insect cell lines.
Pseudorabies
Identification of lumbar spinal neurons controlling simultaneously the prostate and the bulbospongiosus muscles in the rat.
Pseudorabies
Propagation of pseudorabies virus in the nervous system of the mouse after intranasal inoculation.
Pseudorabies
Rapid identification and quantitation of cells infected by recombinant herpesvirus (pseudorabies virus) using a fluorescence-based beta-galactosidase assay and flow cytometry.
Pulmonary Fibrosis
Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix.
Reflex, Abnormal
Juvenile neurogenic muscle atrophy with lysosomal enzyme deficiencies: new disease or variant of mucopolysaccharidosis?
Relative Energy Deficiency in Sport
Developmental expression of a type II collagen/beta-galactosidase fusion gene in transgenic mice.
Relative Energy Deficiency in Sport
MiR-486-3p promotes osteogenic differentiation of BMSC by targeting CTNNBIP1 and activating the Wnt/?-catenin pathway.
Relative Energy Deficiency in Sport
Sustainable aquaculture side-streams derived hybrid biocomposite for bone tissue engineering.
Relative Energy Deficiency in Sport
Transcriptome-wide m6A methylome during osteogenic differentiation of human adipose-derived stem cells.
Reperfusion Injury
Beta-galactosidase as a marker of ischemic injury and a mechanism for viability assessment in porcine liver transplantation.
Retinal Degeneration
An immune response after intraocular administration of an adenoviral vector containing a beta galactosidase reporter gene slows retinal degeneration in the rd mouse.
Retinal Degeneration
Immune consequences of intraocular administration of modified adenoviral vectors.
Retinoblastoma
A melanoma cell line sensitive to expression of a fusion protein binding the retinoblastoma protein family pocket domain.
Retinoblastoma
Estrogen receptor alpha inhibits senescence-like phenotype and facilitates transformation induced by oncogenic ras in human mammary epithelial cells.
Retinoblastoma
Ha-Ras(G12V) induces senescence in primary and immortalized human esophageal keratinocytes with p53 dysfunction.
Retinoblastoma
Indoxyl sulfate, a uremic toxin, promotes cell senescence in aorta of hypertensive rats.
Retinoblastoma
Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts.
Retinoblastoma
Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer.
Retinoblastoma
The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program.
Retinoblastoma
The expression of the retinoblastoma gene product Rb1 in primary and adenovirus-transformed human cells.
Retinoblastoma
Use of a retroviral vector with an internal opsin promoter to direct gene expression to retinal photoreceptor cells.
Retroviridae Infections
Gene transfer of lacZ into avian neural tube and neural crest cells by retroviral infection of grafted embryonic tissues.
Sarcoidosis
Spontaneous hydrogen peroxide release from alveolar macrophages of patients with active sarcoidosis: comparison with cigarette smokers.
Sarcoma
1998 ARRS President's Award. The potential of in vivo vascular tissue engineering for the treatment of vascular thrombosis: a preliminary report. American Roentgen Ray Society.
Sarcoma
Additive effect of adenovirus-mediated E2F-1 gene transfer and topoisomerase II inhibitors on apoptosis in human osteosarcoma cells.
Sarcoma
Efficient incorporation of transfected blastodermal cells into chimeric chicken embryos.
Sarcoma
Myeloproliferative sarcoma virus directed expression of beta-galactosidase following retroviral transduction of murine hematopoietic cells.
Sarcoma
Transcriptional regulation of a contractile gene by mechanical forces applied through integrins in osteoblasts.
Sarcoma
Viral interference during simultaneous transduction with two independent helper-free retroviral vectors.
Sarcoma
[Analysis of expression of the RSV-lacZ-gene in transgenic embryos of the loach Misgurnus fossilis L. during different variations of injection]
Sarcoma, Avian
A transgene containing lacZ is expressed in primary sensory neurons in zebrafish.
Sarcoma, Avian
Activity assays of nine heterogeneous promoters in neural and other cultured cells.
Sarcoma, Avian
Adenoviral vector as a gene delivery system into cultured rat neuronal and glial cells.
Sarcoma, Avian
Adenovirus-mediated gene transfer during initial organogenesis in the mammalian embryo is promoter-dependent and tissue-specific.
Sarcoma, Avian
Adenovirus-mediated gene transfer in vivo to cerebral blood vessels and perivascular tissue in mice.
Sarcoma, Avian
Adenovirus-mediated gene transfer is augmented in basilar and carotid arteries of heritable hyperlipidemic rabbits.
Sarcoma, Avian
Bacterial beta-galactosidase as a marker of Rous sarcoma virus gene expression and replication.
Sarcoma, Avian
Baculovirus-mediated expression of bacterial genes in dipteran and mammalian cells.
Sarcoma, Avian
Calcium phosphate transfection and cell-specific expression of heterologous genes in primary fetal rat hepatocytes.
Sarcoma, Avian
Characterization of Rous sarcoma virus sequences essential for viral gene expression.
Sarcoma, Avian
Characterization of the nuclear localization signal in the avian sarcoma virus integrase.
Sarcoma, Avian
Construction of plasmids for expression of Rous sarcoma virus transforming protein, p60src, in Escherichia coli.
Sarcoma, Avian
Efficient gene transfer into nondividing cells by adeno-associated virus-based vectors.
Sarcoma, Avian
Engineering ex vivo-expanded marrow stromal cells to secrete calcitonin gene-related peptide using adenoviral vector.
Sarcoma, Avian
Evaluation of promoter strength in mouse and rat primary hepatocytes using adenovirus vectors.
Sarcoma, Avian
Evidence for positive and negative regulation in the promoter of the chicken delta 1-crystallin gene.
Sarcoma, Avian
Expression from cardiomyocyte-specific promoter after adenovirus-mediated gene transfer in vitro and in vivo.
Sarcoma, Avian
Expression of recombinant genes in myocardium in vivo after direct injection of DNA.
Sarcoma, Avian
Gene transfer to the human trabecular meshwork by anterior segment perfusion.
Sarcoma, Avian
Generation of an adenovirus vector lacking E1, e2a, E3, and all of E4 except open reading frame 3.
Sarcoma, Avian
In vitro assessment of variables affecting the efficiency and efficacy of adenovirus-mediated gene transfer to cystic fibrosis airway epithelia.
Sarcoma, Avian
In vivo adenovirus-mediated suicide gene therapy of orthotopic bladder cancer.
Sarcoma, Avian
In vivo suppression of osteosarcoma pulmonary metastasis with intravenous osteocalcin promoter-based toxic gene therapy.
Sarcoma, Avian
Infection efficiency of human and mouse embryonic stem cells using adenoviral and adeno-associated viral vectors.
Sarcoma, Avian
Liposome-mediated gene transfer to fetal human ventral mesencephalic explant cultures.
Sarcoma, Avian
Myocardial gene transfer by selective pressure-regulated retroinfusion of coronary veins.
Sarcoma, Avian
Neuroprotection of spinal motoneurons following targeted transduction with an adenoviral vector carrying the gene for glial cell line-derived neurotrophic factor.
Sarcoma, Avian
Phase I study of a recombinant adenovirus-mediated gene transfer in lung cancer patients.
Sarcoma, Avian
Polycation-DNA complexes for gene delivery: a comparison of the biopharmaceutical properties of cationic polypeptides and cationic lipids.
Sarcoma, Avian
Transactivation of the early SV40 promoter by avian infectious laryngotracheitis virus in avian hepatoma cells.
Sarcoma, Avian
[Expression of the CMV-lacZ- and RSV-lacZ-genes in transgenic fish and mouse embryos]
Scleroderma, Diffuse
Origin of the enhanced activity of lysosomal beta-galactosidase in serum and skin in progressive systemic sclerosis.
Scleroderma, Diffuse
[Effect of penicillin and D-penicillamine on beta-galactosidase activity in patients with progressive scleroderma]
Scleroderma, Diffuse
[N-procollagen(III)peptide and lysosomal beta-galactosidase in progressive scleroderma and silicosis]
Scleroderma, Systemic
Type III collagen aminopropeptide and laminin P1 levels in serum of patients with silicosis-associated and idiopathic systemic scleroderma.
Scleroderma, Systemic
[Beta-Galactosidase activity in serum of systemic sclerosis (author's transl)]
Scrapie
Indicator expression directed by regulatory sequences of the glial fibrillary acidic protein (GFAP) gene: in vivo comparison of distinct GFAP-lacZ transgenes.
Seizures
Adult GM1 gangliosidosis: clinical and biochemical studies on two patients and comparison to other patients called variant or adult GM1 gangliosidosis.
Seizures
Attenuation of seizure in P77PMC rats with an HSV-vector expressing IL-1ra in brain.
Seizures
Macular cherry-red spots and beta-galactosidase deficiency in an adult. An autopsy case with progressive cerebellar ataxia, myoclonus, thrombocytopathy, and accumulation of polysaccharide in liver.
Seizures
Overexpression of GluR6 in rat hippocampus produces seizures and spontaneous nonsynaptic bursting in vitro.
Sepsis
Highly increased levels of serum beta-hexosaminidase, arylsulphatase A and beta-galactosidase in a patient with sepsis.
Sepsis
Tumour necrosis factor-alpha causes an increase in blood-brain barrier permeability during sepsis.
Sialadenitis
Effect of human vasoactive intestinal peptide gene transfer in a murine model of Sjogren's syndrome.
Silicosis
[Early detection of scleroderma in quartz dust exposed workers and workers with silicosis by determining serum beta-galactosidase activity]
Silicosis
[N-procollagen(III)peptide and lysosomal beta-galactosidase in progressive scleroderma and silicosis]
Silicotuberculosis
Histoenzymology of the lung. II. The behaviour of lung hydrolytic enzymes during some experimental pulmonary processes.
Sleep Deprivation
Sleep deprivation increases the activation of nuclear factor kappa B in lateral hypothalamic cells.
Sphingolipidoses
Lactosylceramide beta-galactosidase in human sphingolipidoses. Evidence for two genetically distinct enzymes.
Spinocerebellar Ataxias
USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene product.
Squamous Cell Carcinoma of Head and Neck
Evaluation of topical gene therapy for head and neck squamous cell carcinoma in an organotypic model.
Squamous Cell Carcinoma of Head and Neck
Head and neck cancer cells are efficiently infected by Ad5/35 hybrid virus.
Squamous Cell Carcinoma of Head and Neck
Interference with the bromodomain epigenome readers drives p21 expression and tumor senescence.
Squamous Cell Carcinoma of Head and Neck
Suicide gene therapy for human oral squamous cell carcinoma cell lines with adeno-associated virus vector.
Starvation
A second protein disulfide isomerase plays a protective role against nitrosative and nutritional stresses in Schizosaccharomyces pombe.
Starvation
Analysis of teichoic acid biosynthesis regulation reveals that the extracytoplasmic function sigma factor sigmaM is induced by phosphate depletion in Bacillus subtilis W23.
Starvation
beta-Galactosidase activity of Escherichia coli under long-term starvation, alterations in temperature, and different nutrient conditions in lake water.
Starvation
Cell cycle regulation of the Escherichia coli nrd operon: requirement for a cis-acting upstream AT-rich sequence.
Starvation
Characterization of the carbon starvation-inducible and stationary phase-inducible gene slp encoding an outer membrane lipoprotein in Escherichia coli.
Starvation
Characterization of the regulatory region of a cell interaction-dependent gene in Myxococcus xanthus.
Starvation
Cloning, characterization and regulation of a protein disulfide isomerase from the fission yeast Schizosaccharomyces pombe.
Starvation
Control of protein synthesis in Escherichia coli: strain differences in control of translational initiation after energy source shift-down.
Starvation
Differential regulation by cyclic AMP of starvation protein synthesis in Escherichia coli.
Starvation
Effect of u.v. light irradiation, starvation and heat on Escherichia coli beta-D-galactosidase activity and other potential viability parameters.
Starvation
Effects of starvation for exogenous carbon on functional mRNA stability and rate of peptide chain elongation in Escherichia coli.
Starvation
Escherichia coli ferric uptake regulator (Fur) can mediate regulation of a pseudomonad iron-regulated promoter.
Starvation
Formation of the LuxR protein in the Vibrio fischeri lux system is controlled by HtpR through the GroESL proteins.
Starvation
Glycosyl hydrolases of cell wall are induced by sugar starvation in Arabidopsis.
Starvation
Identification and characterization of a relA-dependent starvation-inducible locus (sin) in Salmonella typhimurium.
Starvation
Identification of sulfate starvation-regulated genes in Escherichia coli: a gene cluster involved in the utilization of taurine as a sulfur source.
Starvation
Identification of the omega4400 regulatory region, a developmental promoter of Myxococcus xanthus.
Starvation
Isolation and characterization of a mutant defective in triacylglycerol accumulation in nitrogen-starved Chlamydomonas reinhardtii.
Starvation
Molecular cloning, characterization and regulation of a peroxiredoxin gene from Schizosaccharomyces pombe.
Starvation
Mutagenesis of Erwinia carotovora subsp. carotovora with bacteriophage Mu d1 (Apr lac cts62): construction of his-lac gene fusions.
Starvation
Posttranscriptional regulation of FLO11 upon amino acid starvation in Saccharomyces cerevisiae.
Starvation
Proline biosynthesis in Saccharomyces cerevisiae: molecular analysis of the PRO1 gene, which encodes gamma-glutamyl kinase.
Starvation
Protective role and regulation of Rad9 from the fission yeast Schizosaccharomyces pombe.
Starvation
Protective roles and Pap1-dependent regulation of the Schizosaccharomyces pombe spy1 gene under nitrosative and nutritional stresses.
Starvation
Response of heterogenous rat liver lysosome populations to starvation and refeeding.
Starvation
Screening and characterization of transposon-insertion mutants in a pseudohyphal strain of Saccharomyces cerevisiae.
Starvation
Stabilization of a HemA-LacZ hybrid protein against proteolysis during carbon starvation in atp mutants of Salmonella typhimurium.
Starvation
Starvation stress modulates the expression of the Aspergillus nidulans brlA regulatory gene.
Starvation
Synthesis of beta-galactosidase messenger RNA during amino acid starvation of stringent and relaxed strains of Escherichia coli.
Starvation
Synthesis of inactive beta-galactosidase during amino acid starvation in Escherichia coli K-12.
Starvation
Synthesis of inducible enzyme in Escherichia coli recovering from prolonged energy starvation.
Starvation
The gene encoding gamma-glutamyl transpeptidase II in the fission yeast is regulated by oxidative and metabolic stress.
Starvation
The pap1(+) gene of fission yeast is transcriptionally regulated by nitrosative and nutritional stress.
Starvation
Three regulatory systems control expression of glutamine synthetase in Saccharomyces cerevisiae at the level of transcription.
Starvation
Transcription of ppk from Acinetobacter sp. strain ADP1, encoding a putative polyphosphate kinase, is induced by phosphate starvation.
Starvation
Transport of 5-aminolevulinic acid by the dipeptide permease in Salmonella typhimurium.
Starvation
Unusual stability and translation kinetics of an Escherichia coli lac messenger RNA synthetized during amino-acids deprivation.
Starvation
Use of glucose starvation to limit growth and induce protein production in Escherichia coli.
Stomach Neoplasms
In vivo selective gene expression and therapy mediated by adenoviral vectors for human carcinoembryonic antigen-producing gastric carcinoma.
Stomach Ulcer
[Immunohistochemical studies on non neoplastic and neoplastic gastric mucosa. Determination of embryonic and specific antigens (author's transl)]
Stomatitis
Dose-dependent transduction of vesicular stomatitis virus G protein-pseudotyped retrovirus vector into human solid tumor cell lines and murine fibroblasts.
Subacute Sclerosing Panencephalitis
Regulation of expression of genes coding for small, acid-soluble proteins of Bacillus subtilis spores: studies using lacZ gene fusions.
Superinfection
A gene delivery/recall system for neurons which utilizes ribonucleotide reductase-negative herpes simplex viruses.
Superinfection
A novel type of dimerization motif, related to leucine zippers, is present in plant homeodomain proteins.
Superinfection
Complex structure of the nuclear translocation signal of influenza virus polymerase PA subunit.
Superinfection
Generation of high-titer defective HSV-1 vectors using an IE 2 deletion mutant and quantitative study of expression in cultured cortical cells.
Superinfection
Long-term expression in sensory neurons in tissue culture from herpes simplex virus type 1 (HSV-1) promoters in an HSV-1-derived vector.
Superinfection
Quiescent viral genomes in human fibroblasts after infection with herpes simplex virus type 1 Vmw65 mutants.
Superinfection
Translational polarity of a mutation in the initiator AUG codon of the lambda cI gene.
Tay-Sachs Disease
Electron microscopic examination of skin and conjunctival biopsy specimens in neuronal storage diseases.
Tay-Sachs Disease
Lymphoblastoid cell lines, transformed by Epstein-Barr virus, in the enzymatic study of hereditary lysosomal storage diseases.
Teratocarcinoma
Cloning and characterization of 5'-upstream sequence of the M32 gene for a mouse homologue of Drosophila heterochromatin protein 1 (HP1).
Teratocarcinoma
Direct visualization, by beta-galactosidase histochemistry, of differentiated normal cells derived from malignant teratocarcinoma in allophenic mice.
Teratocarcinoma
Expression of the lacZ gene targeted to the HPRT locus in embryonic stem cells and their derivatives.
Teratocarcinoma
Packaging of endogenous retroviral sequences in retroviral vectors produced by murine and human packaging cells.
Teratocarcinoma
The linear tetrasaccharide, Gal beta 1-4GlcNAc beta 1-6Gal beta 1-4GlcNAc, isolated from radiolabeled teratocarcinoma poly-N-acetyllactosaminoglycan resists the action of E. freundii endo-beta-galactosidase.
Tetanus
Brain-derived neurotrophic factor facilitates in vivo internalization of tetanus neurotoxin C-terminal fragment fusion proteins in mature mouse motor nerve terminals.
Tetanus
C fragment of tetanus toxin hybrid proteins evaluated for muscle-specific transsynaptic mapping of spinal motor circuitry in the newborn mouse.
Tetanus
Leaky Lactococcus cultures that externalize enzymes and antigens independently of culture lysis and secretion and export pathways.
Tetanus
Secretion from bovine chromaffin cells acutely expressing exogenous proteins using a recombinant Semliki Forest virus containing an EGFP reporter.
Tetanus
Structure of the VH and VL segments of polyreactive and monoreactive human natural antibodies to HIV-1 and Escherichia coli beta-galactosidase.
Thrombosis
1998 ARRS President's Award. The potential of in vivo vascular tissue engineering for the treatment of vascular thrombosis: a preliminary report. American Roentgen Ray Society.
Thrombosis
Adenovirus-mediated transfer of beta-galactosidase and prourokinase genes into vein grafts.
Thrombosis
Local gene delivery: arterial thrombosis model for endothelial cell-targeted thrombolytic gene therapy research.
Thrombosis
Thrombus generation after adenovirus-mediated gene transfer into atherosclerotic arteries.
Thyroid Neoplasms
Adenoviral infection of thyroid cells: a rationale for gene therapy for metastatic thyroid carcinoma.
Thyroid Neoplasms
Cell-specific induction of sensitivity to ganciclovir in medullary thyroid carcinoma cells by adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase.
Thyroid Neoplasms
Histochemical demonstration and analysis of poly-N-acetyllactosamine structures in normal and malignant human tissues.
Thyroid Neoplasms
Histochemical demonstration of different types of poly-N-acetyllactosamine structures in human thyroid neoplasms using lectins and endo-beta-galactosidase digestion.
Thyroiditis
Antibodies reactive with an intracellular epitope of a recombinant 64 kDa thyroid and eye muscle protein in patients with thyroid autoimmunity and ophthalmopathy.
Tremor
Adenoviral gene transfer of aspartoacylase into the tremor rat, a genetic model of epilepsy, as a trial of gene therapy for inherited epileptic disorder.
Tuberculosis
Analysis of the shotgun expression library of the Mycobacterium tuberculosis genome for immunodominant polypeptides: potential use in serodiagnosis.
Tuberculosis
Histoenzymology of the lung. II. The behaviour of lung hydrolytic enzymes during some experimental pulmonary processes.
Tuberculosis
Identification and characterization of rel promoter element of Mycobacterium tuberculosis.
Tuberculosis
Inhibition of bacterial disulfide bond formation by the anticoagulant warfarin.
Tuberculosis
Regulation of the expression of whiB1 in Mycobacterium tuberculosis: role of cAMP receptor protein.
Tuberculosis
T cell responses of normal individuals towards recombinant protein antigens of Mycobacterium tuberculosis.
Tuberculosis
[Chronorogical changes in activities of various enzymes including beta-galactosidase and naphthol AS-D acetate esterase of the mononuclear phagocytes in tuberculosis lesions (author's transl)]
Urinary Bladder Neoplasms
Adenoviral p53 gene transfer in human bladder cancer cell lines: cytotoxicity and synergy with cisplatin.
Urinary Bladder Neoplasms
An improved intravesical model using human bladder cancer cell lines to optimize gene and other therapies.
Urinary Bladder Neoplasms
Intravesical liposome-mediated interleukin-2 gene therapy in orthotopic murine bladder cancer model.
Urinary Bladder Neoplasms
Tumor-specific gene delivery mediated by a novel peptide-polyethylenimine-DNA polyplex targeting aminopeptidase N/CD13.
Urolithiasis
Increased urinary excretion of renal enzymes in idiopathic calcium oxalate nephrolithiasis.
Uterine Cervical Neoplasms
Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer.
Uveitis
Chronic uveitis in guinea pigs infected with varicella-zoster virus expressing Escherichia coli beta-galactosidase.
Vaccinia
A consideration of previously uncharacterized fowl poxvirus unidirectional and bidirectional late promoters for inclusion in homologous recombinant vaccines.
Vaccinia
Active immunotherapy of cancer with a nonreplicating recombinant fowlpox virus encoding a model tumor-associated antigen.
Vaccinia
Anti-tumor activity of cytotoxic T lymphocytes elicited with recombinant and synthetic forms of a model tumor-associated antigen.
Vaccinia
Antigen expression by dendritic cells correlates with the therapeutic effectiveness of a model recombinant poxvirus tumor vaccine.
Vaccinia
Antigen-specific tumor vaccine efficacy in vivo against prostate cancer with low class I MHC requires competent class II MHC.
Vaccinia
Antitumor efficacy of tumor-antigen-encoding recombinant poxvirus immunization in Dunning rat prostate cancer: implications for clinical genetic vaccine development.
Vaccinia
Beta galactosidase release as an alternative to chromium release in cytotoxic T-cell assays.
Vaccinia
Comparative analysis of the conserved region of the orthopoxvirus genome encoding the 36K and 12K proteins.
Vaccinia
Construction and characterization of a triple-recombinant vaccinia virus encoding B7-1, interleukin 12, and a model tumor antigen.
Vaccinia
Construction of fowlpox virus vectors with intergenic insertions: expression of the beta-galactosidase gene and the measles virus fusion gene.
Vaccinia
Costimulation enhances the active immunotherapy effect of recombinant anticancer vaccines.
Vaccinia
Delineation of the viral products of recombination in vaccinia virus-infected cells.
Vaccinia
Early gene expression of vaccinia virus strains replicating (Praha) and non-replicating (modified vaccinia virus strain Ankara, MVA) in mammalian cells.
Vaccinia
Engulfment of apoptotic cells expressing HCV proteins leads to differential chemokine expression and STAT signaling in human dendritic cells.
Vaccinia
Flow cytometric quantitation of the protective efficacy of dendritic cell based vaccines in a human papillomavirus type 16 murine challenge model.
Vaccinia
Gene transfer by viral vectors into blood vessels in a rat model of retinopathy of prematurity.
Vaccinia
Gene transfer into the mammalian inner ear using HSV-1 and vaccinia virus vectors.
Vaccinia
Gene transfer mediated by different viral vectors following direct cannulation of mouse submandibular salivary glands.
Vaccinia
High level protein expression in mammalian cells using a safe viral vector: Modified vaccinia virus Ankara.
Vaccinia
High-level expression of Amsacta moorei entomopoxvirus spheroidin depends on sequences within the gene.
Vaccinia
Highly efficient expression of proteins encoded by recombinant vaccinia virus in lymphocytes.
Vaccinia
Host range selection of vaccinia recombinants containing insertions of foreign genes into non-coding sequences.
Vaccinia
IL-12 is an effective adjuvant to recombinant vaccinia virus-based tumor vaccines: enhancement by simultaneous B7-1 expression.
Vaccinia
Interleukin-10 enhances the therapeutic effectiveness of a recombinant poxvirus-based vaccine in an experimental murine tumor model.
Vaccinia
Measles virus and canine distemper virus target proteins into a TAP-independent MHC class I-restricted antigen-processing pathway.
Vaccinia
Novel oncolytic agent GLV-1h68 is effective against malignant pleural mesothelioma.
Vaccinia
Quantitative assessment of poxvirus promoters in fowlpox and vaccinia virus recombinants.
Vaccinia
Reintroduction of gene(s) into an attenuated deletion mutant of vaccinia virus strain IHD-W.
Vaccinia
Selection of recombinant vaccinia viruses (Tian Tan strain) expressing hepatitis B virus surface antigen by using beta-galactosidase as a marker.
Vaccinia
Selective humoral immune response of Balb/C mice to Brucella abortus proteins expressed by vaccinia virus recombinants.
Vaccinia
Statistical approach to estimate vaccinia-specific neutralizing antibody titers using a high-throughput assay.
Vaccinia
Stringent chemical and thermal regulation of recombinant gene expression by vaccinia virus vectors in mammalian cells.
Vaccinia
Targeting of vaccinia virus using biotin-avidin viral coating and biotinylated antibodies.
Vaccinia
The 5' noncoding region sequence of the Choristoneura biennis entomopoxvirus spheroidin gene functions as an efficient late promoter in the mammalian vaccinia expression system.
Vaccinia
The amino terminus of the adenovirus fiber protein encodes the nuclear localization signal.
Vaccinia
The gene encoding the late nonstructural 36K protein of vaccinia virus is essential for virus reproduction.
Vaccinia
Transfer of the inducible lac repressor/operator system from Escherichia coli to a vaccinia virus expression vector.
Vaccinia
Tumor growth inhibition elicited by different vaccines and correlation with antigen specific cytotoxic T-cell frequencies determined by intracellular interferon-gamma staining.
Vaccinia
Tumor-induced interleukin-10 inhibits type 1 immune responses directed at a tumor antigen as well as a non-tumor antigen present at the tumor site.
Vaccinia
Vaccinia as a tool for functional analysis in regenerating limbs: ectopic expression of Shh.
Vaccinia
Vaccinia virus expression vector: coexpression of beta-galactosidase provides visual screening of recombinant virus plaques.
Vaccinia
Vaccinia virus recombinants expressing an 11-kilodalton beta-galactosidase fusion protein incorporate active beta-galactosidase in virus particles.
Vaccinia
Vaccinia virus vectors utilizing the beta-galactosidase assay for rapid selection of recombinant viruses and measurement of gene expression.
Vaccinia
Viable double vaccinia virus recombinants with the non-inducible phage T7 expression system.
Vaccinia
[Analysis of reporter gene expression at different segments of the vaccinia virus genome]
Vaccinia
[Expression of beta-galactosidase in recombinant nonintegrated plasmids in evaluating the functional activity of vaccinia virus promoters]
Vaccinia
[Expression of the glow worm luciferase gene in mammalian cells using vectors based on vaccinia viruses]
Vaccinia
[Insertion mutants of the vaccinia virus. The effect of inactivating E7R and D8L genes on the biological properties of the virus]
Vaccinia
[Methods of isolating and selecting recombinant vaccinia viruses expressing heterogenetic viral antigens]
Vaccinia
[Molecular biological study of the vaccinia virus genome. IV. The late nonstructural 36K protein of vaccinia virus is vitally important]
Vaccinia
[Quantitative analysis of cell fusion caused by glycoprotein of paramyxoviruses with reporter gene method]
Varicocele
Abnormal expression of acid glycosidases in seminal plasma and spermatozoa from infertile men with varicocele.
Varicose Ulcer
The effect of passage number on fibroblast cellular senescence in patients with chronic venous insufficiency with and without ulcer.
Varicose Ulcer
Venous ulcer fibroblasts respond to basic fibroblast growth factor at the cell cycle protein level.
Vascular Calcification
The effects of hyperuricemia on the differentiation and proliferation of osteoblasts and vascular smooth muscle cells are implicated in the elevated risk of osteopenia and vascular calcification in gout: An in vivo and in vitro analysis.
Vascular Diseases
Cytochemical detection of a senescence-associated beta-galactosidase in endothelial and smooth muscle cells from human and rabbit blood vessels.
Vascular Diseases
Enzymes and cytomorphological sperm alterations in some diseases of the male reproductive system.
Vascular Ring
Ex vivo gene transfer of endothelial nitric oxide synthase to atherosclerotic rabbit aortic rings improves relaxations to acetylcholine.
Vascular System Injuries
In vivo gene transfer: prevention of neointima formation by inhibition of mitogen-activated protein kinase kinase.
Vascular System Injuries
Selective neointimal gene transfer in an avian model of vascular injury.
Vascular System Injuries
Stress-induced Senescence Exaggerates Post Injury Neointimal Formation in the Old Vasculature.
Vesicular Stomatitis
Feasibility of retroviral vector-mediated in utero gene transfer to the fetal rabbit.
Vesicular Stomatitis
Gene transfer to the nonhuman primate retina with recombinant feline immunodeficiency virus vectors.
Vesicular Stomatitis
Involvement of carbohydrates in vesicular stomatitis virus-cell early interaction.
Vesicular Stomatitis
Noncytopathic flavivirus replicon RNA-based system for expression and delivery of heterologous genes.
Vesicular Stomatitis
Optimization of human erythropoietin secretion from MLV-infected human primary fibroblasts used for encapsulated cell therapy.
Vesicular Stomatitis
Retrovirus-mediated transduction of porcine keratinocytes in organ culture.
Vesicular Stomatitis
Role of hepatocyte direct hyperplasia in lentivirus-mediated liver transduction in vivo.
Virus Diseases
5' sequence of vesicular stomatitis virus N-gene confers selective translation of mRNA.
Virus Diseases
Adeno-associated virus-mediated osteoprotegerin gene transfer protects against particulate polyethylene-induced osteolysis in a murine model.
Virus Diseases
Characterization of SA-11 rotavirus receptorial structures on human colon carcinoma cell line HT-29.
Virus Diseases
Contribution of the C-terminal tri-lysine regions of human immunodeficiency virus type 1 integrase for efficient reverse transcription and viral DNA nuclear import.
Virus Diseases
Dominant negative Rab3D inhibits amylase release from mouse pancreatic acini.
Virus Diseases
Effects of baculovirus infection on IE1-mediated foreign gene expression in stably transformed insect cells.
Virus Diseases
Isolation and Characterization of Pepper Genes Interacting with the CMV-P1 Helicase Domain.
Virus Diseases
Migration of virus-infected neuronal cells in cerebral slice cultures of developing mouse brains after in vitro infection with murine cytomegalovirus.
Virus Diseases
Pretreatment with protease is a useful experimental strategy for enhancing adenovirus-mediated cancer gene therapy.
Virus Diseases
Reduction of type V collagen using a dominant-negative strategy alters the regulation of fibrillogenesis and results in the loss of corneal-specific fibril morphology.
Virus Diseases
Replication-defective virus infection of feather buds produces a localized region of beta-galactosidase activity.
Virus Diseases
Role of membrane phospholipids and glycolipids in the Vero cell surface receptor for rubella virus.
Virus Diseases
Signalling mechanisms in contraction-mediated stimulation of intracellular NO production in cat ventricular myocytes.
Virus Diseases
Significant increase in recombinant protein production of a virus-infected Sf-9 insect cell culture of low MOI under low dissolved oxygen conditions.
Virus Diseases
Superinfection prevents recombination of the alphaherpesvirus bovine herpesvirus 1.
Virus Diseases
Transactivation of the early SV40 promoter by avian infectious laryngotracheitis virus in avian hepatoma cells.
Virus Diseases
Tricyclo-DNA containing oligonucleotides as steric block inhibitors of human immunodeficiency virus type 1 tat-dependent trans-activation and HIV-1 infectivity.
Virus Diseases
Use of recombinant herpes simplex virus type 1 vectors for gene transfer into tumour and normal anterior pituitary cells.
Virus Diseases
[Using reporter gene to compare infection efficiency of HIV-1 pseudovirus to suspended and adherent cells].
Vitamin A Deficiency
Histochemical studies on the salivary glands in white rats in vitamin A deficiency. I. Beta-glucuronidase and beta-galactosidase in secretory cells of the sublingual and submandibular glands.
Werner Syndrome
No increase in senescence-associated beta-galactosidase activity in Werner syndrome fibroblasts after exposure to H2O2.
Whooping Cough
Bordetella pertussis filamentous hemagglutinin gene: molecular cloning of a potential coding sequence.
Whooping Cough
DNA-based vaccination reduces the risk of lethal anaphylactic hypersensitivity in mice.
Whooping Cough
Use of the promoter fusion transposon Tn5 lac to identify mutations in Bordetella pertussis vir-regulated genes.
Xeroderma Pigmentosum
DNA adducts of cis-diamminedichloroplatinum(II) and its trans isomer inhibit RNA polymerase II differentially in vivo.
Xeroderma Pigmentosum
Enhanced host cell reactivation of a UV-damaged reporter gene in pre-UV-treated cells is delayed in Cockayne syndrome cells.
Xeroderma Pigmentosum
Increased expression of p53 enhances transcription-coupled repair and global genomic repair of a UVC-damaged reporter gene in human cells.
Yellow Fever
Reduction of yellow fever virus mouse neurovirulence by immunization with a bacterially synthesized non-structural protein (NS1) fragment.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.59
4-methylumbelliferyl beta-D-galactoside
-
fibroblast enzyme of GM1 gangliosidosis heterozygotes
0.65
4-methylumbelliferyl beta-D-galactoside
-
leukocyte enzyme of GM1 gangliosidosis heterozygotes
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
in vivo enzyme activity in different fibroblast lines, cells in different growth stages, overview
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
4.2
-
enzyme from leukocytes and fibroblasts of normal individuals, and fibroblast enzyme of GM1 gangliosidosis heterozygotes
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pI VALUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
5.6
-
thioredoxin-His portion removed cytoplasmic transduction peptide-beta-gal recombinant protein, calculated from amino acid sequence
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
of GM1 gangliosidosis heterozygotes compared to normal subjects
brenda
additional information
-
senescence-associated beta-galactosidase activity is strongly associated with senescent cells, since it is not detectable in quiescent cells or terminally differentiated cells
brenda
-
of GM1 gangliosidosis heterozygotes compared to normal subjects
brenda
-
confluency and contact inhibition of growth can cause a small increase in the expression. Senescent phenyotype is correlated with an increase in total beta-galactosidase
brenda
-
low activity during exponential growth phase, but increasing activity during decreasing culture growth and decreased mitotic activity
brenda
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). BGAL_HUMAN
677
0
76075
Swiss-Prot
Secretory Pathway (Reliability: 2)
A0A024R3N9_HUMAN
636
1
72079
TrEMBL
Secretory Pathway (Reliability: 5)
F4YK10_HUMAN
21
0
2305
TrEMBL
Secretory Pathway (Reliability: 1)
Q53H18_HUMAN
677
0
76110
TrEMBL
Secretory Pathway (Reliability: 2)
Q53G40_HUMAN
677
0
76069
TrEMBL
Secretory Pathway (Reliability: 2)
B7Z5H9_HUMAN
546
0
60552
TrEMBL
Secretory Pathway (Reliability: 1)
E7EQ29_HUMAN
546
0
60483
TrEMBL
Secretory Pathway (Reliability: 2)
A0A679KTH4_HUMAN
1279
0
145526
TrEMBL
other Location (Reliability: 1)
B7Z6Q5_HUMAN
725
1
81803
TrEMBL
Secretory Pathway (Reliability: 2)
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
120800
-
thioredoxin-His portion removed cytoplasmic transduction peptide-beta-gal recombinant protein, calculated from amino acid sequence
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
proteolytic modification
-
in normal cells an 84000 Da precursor is processed first to an intermediate form of higher molecular weight and then to a 64000 Da mature enzyme. In one case of GM1-gangliosidosis a precursor of abnormally high molecular weight is observed, no further processing occurs to the 88000 Da enzyme form
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
transfection of beta-galactosidase gene to fibroblast cells in culture using liposomes. 24 h after transfection, treated cells show a higher specific enzyme activity than untreated cells. Cells maintained in culture for 7 days show values similar to those of untreated patients with GM1 gangliosidosis
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
42
-
80 min,75% loss of leukocte enzyme from GM1 gangliosidosis heterozygotes,70% loss of fibroblast enzyme from GM1 gangliosidosis heterozygotes
45
-
50 min, about 50% loss of phlorizin hydrolase activity, about 70% loss of lactase activity
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
84000 Da precursor expressed in recombinant baculovirus-infected Spodoptera frugiperda
-
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
84000 Da precursor expressed in recombinant baculovirus-infected Spodoptera frugiperda
-
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
in human fibroblasts, the overexpression of plasma membrane associated sialidase Neu3 induces an about 2fold increase of beta-galactosidase expression and activity
-
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
analysis
-
the enzyme is a reliable marker for the course of replicative cell senescence
diagnostics
-
the enzyme is a reliable marker for the course of replicative cell senescence
medicine
-
transfection of beta-galactosidase gene to fibroblast cells in culture using liposomes. 24 h after transfection, treated cells show a higher specific enzyme activity than untreated cells. Cells maintained in culture for 7 days show values similar to those of untreated patients with GM1 gangliosidosis
molecular biology
-
senescence-associated beta-galactosidase activity is a widely used biomarker for assessing replicative sensescence in mammalian cells. Quantitative assay of senescence-associated beta-galactosidase activity in mammalian cell extracts. The assay is capable of detecting relatively subtle changes in activity and confirms that confluency and contact inhibition of growth can cause a small increase in the expression of this biomarker. The assay for measuring senescence-associated changes in beta-galactosidase is suitable for mechanistic studies of senescence regulation in which graduated changes in biomarker expression may be anticipated
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wallenfels, K.; Weil, R.
beta-Galactosidase
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
7
617-663
1972
Enterobacter cloacae, Aeromonas caviae, Priestia megaterium, Bacillus subtilis, Bos taurus, Streptococcus pneumoniae, Escherichia coli, Helix pomatia, Ovis aries, Homo sapiens, Kluyveromyces lactis, Lactococcus lactis, Paracolobactrum aerogenoides, Rattus norvegicus, Saccharomyces fragilis, Shigella dysenteriae, Hamamotoa singularis, Tritrichomonas suis, Escherichia coli ML 309, Escherichia coli ML 35
-
brenda
Wallenfels, K.; Malhotra, O.M.
beta-Galactosidase
The Enzymes, 2nd Ed (Boyer, P. D. , Lardy, H. , Myrbck, K. , eds. )
4
409-430
1960
Klebsiella aerogenes, Aspergillus flavus, Aspergillus niger, Aspergillus oryzae, Bos taurus, Canis lupus familiaris, Capra hircus, Coffea sp., Oryctolagus cuniculus, Escherichia coli, Felis catus, Helix pomatia, Ovis aries, Homo sapiens, Medicago sativa, Malus sp., Neurospora sp., Prunus dulcis, Prunus armeniaca, Prunus persica, Saccharomyces fragilis, Shigella sonnei, Escherichia coli K 12, Escherichia coli ML 308, Escherichia coli ML 309
-
brenda
Lau, H.K.F.
Physicochemical characterization of human intestinal lactase
Biochem. J.
241
567-572
1987
Homo sapiens
brenda
Itoh, K.; Oshima, A.; Sakuraba, H.; Suzuki, Y.
Characterization and purification of human beta-galactosidase overexpressed in recombinant baculovirus-infected Spodoptera frugiperda cells
J. Inherit. Metab. Dis.
14
813-818
1991
Homo sapiens
brenda
Nanba, E.; Tsuji, A.; Omura, K.; Suzuki, Y.
GM1-gangliosidosis: abnormalities in biosynthesis and early processing of beta-galactosidase in fibroblasts
Biochem. Biophys. Res. Commun.
29
794-800
1988
Homo sapiens
brenda
Zhang, S.; Bagshaw, R.; Hilson, W.; Oho, Y.; Hinek, A.; Clarke, J.T.; Callahan, J.W.
Characterization of beta-galactosidase mutations Asp332-->Asn and Arg148-->Ser, and a polymorphism, Ser532-->Gly, in a case of GM1 gangliosidosis
Biochem. J.
348
621-632
2000
Homo sapiens
brenda
Sopelsa, A.M.; Severini, M.H.; da Silva, C.M.; Tobo, P.R.; Giugliani, R.; Coelho, J.C.
Characterization of beta-galactosidase in leukocytes and fibroblasts of GM1 gangliosidosis heterozygotes compared to normal subjects
Clin. Biochem.
33
125-129
2000
Homo sapiens
brenda
Gary, R.K.; Kindell, S.M.
Quantitative assay of senescence-associated beta-galactosidase activity in mammalian cell extracts
Anal. Biochem.
343
329-334
2005
Homo sapiens
brenda
Maier, A.B.; Westendorp, R.G.; VAN Heemst, D.
beta-Galactosidase activity as a biomarker of replicative senescence during the course of human fibroblast cultures
Ann. N. Y. Acad. Sci.
1100
323-332
2007
Homo sapiens
brenda
Balestrin, R.C.; Baldo, G.; Vieira, M.B.; Sano, R.; Coelho, J.C.; Giugliani, R.; Matte, U.
Transient high-level expression of beta-galactosidase after transfection of fibroblasts from GM1 gangliosidosis patients with plasmid DNA
Braz. J. Med. Biol. Res.
41
283-288
2008
Homo sapiens
brenda
Aureli, M.; Masilamani, A.P.; Illuzzi, G.; Loberto, N.; Scandroglio, F.; Prinetti, A.; Chigorno, V.; Sonnino, S.
Activity of plasma membrane beta-galactosidase and beta-glucosidase
FEBS Lett.
583
2469-2473
2009
Homo sapiens
brenda
Debacq-Chainiaux, F.; Erusalimsky, J.D.; Campisi, J.; Toussaint, O.
Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo
Nat. Protoc.
4
1798-1806
2009
Homo sapiens
brenda
Huang, S.F.; Liu, D.B.; Zeng, J.M.; Yuan, Y.; Xiao, Q.; Sun, C.M.; Li, C.L.; Tao, K.; Wen, J.P.; Huang, Z.G.; Feng, W.L.
Cloning, expression, purification, distribution and kinetics characterization of the bacterial beta-galactosidase fused to the cytoplasmic transduction peptide in vitro and in vivo
Protein Expr. Purif.
68
167-176
2009
Homo sapiens
brenda
Seddigh, S.; Darabi, M.
Comprehensive analysis of beta-galactosidase protein in plants based on Arabidopsis thaliana
Turk. J. Biol.
38
140-150
2014
Asparagus officinalis, Persea americana, Musa acuminata, Brassica oleracea, Capsicum annuum, Carica papaya, Ricinus communis, Cicer arietinum, Citrus medica, Citrus sinensis, Coffea arabica, Dianthus caryophyllus, Drosophila melanogaster, Escherichia coli, Ficus carica, Fragaria x ananassa, Glycine max, Gossypium barbadense, Gossypium hirsutum, Homo sapiens, Hordeum vulgare, Linum usitatissimum, Lupinus angustifolius, Solanum lycopersicum, Mangifera indica, Malus domestica, Medicago truncatula, Mus musculus, Narcissus pseudonarcissus, Nicotiana tabacum, Pyrus communis, Petunia x hybrida, Vigna radiata, Physcomitrium patens, Populus trichocarpa, Prunus armeniaca, Prunus persica, Raphanus sativus, Sorghum bicolor, Trifolium pratense, Triticum monococcum, Vitis vinifera, Zea mays, Diospyros kaki, Oryza sativa Japonica Group, Picea sitchensis, Hymenaea courbaril, Cucumis melo var. cantalupo, Selaginella moellendorffii, Fragaria chiloensis, Prunus salicina, Actinidia deliciosa var. deliciosa, Gossypium raimondii, Eutrema halophilum, Gossypium herbaceum subsp. africanum, Sandersonia aurantiaca, Ziziphus jujuba, Arabidopsis thaliana (F4JUE3)
-
brenda
EXTERNAL LINKS (specific for EC-Number 3.2.1.23)
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