Information on EC 3.2.1.22 - alpha-galactosidase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY
3.2.1.22
-
RECOMMENDED NAME
GeneOntology No.
alpha-galactosidase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids
show the reaction diagram
also hydrolyses alpha-D-fucosides
-
-
-
Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids
show the reaction diagram
the recombinant enzyme catalyzes the hydrolysis of phenyl R-galactosides via a redox elimination-addition mechanism involving oxidation of the hydroxyl group at C-3 and elimination of phenol across the C-1-C-2 bond to give an enzyme-bound glycal intermediate
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
hydrolysis of O-glycosyl bond
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Galactose metabolism
-
Glycerolipid metabolism
-
Glycosphingolipid biosynthesis - globo series
-
melibiose degradation
-
Sphingolipid metabolism
-
stachyose degradation
-
SYSTEMATIC NAME
IUBMB Comments
alpha-D-galactoside galactohydrolase
Also hydrolyses alpha-D-fucosides.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
a-galactosidase
-
-
Aga-F78
Rhizopus sp.
-
-
Aga-F78
C7SEV1
-
Aga-F78
Rhizopus sp. F78
-
-
-
AgalB
Bispora sp.
-
-
Agalsidase alfa
-
-
-
-
Agalsidase alfa
-
-
AkalphaGal
-
-
alkaline alpha-gal form 1
-
-
alkaline alpha-galactosidase
-
-
alkaline alpha-galactosidase
-
-
alkaline alpha-galactosidase form 1
-
-
alpha-D-galactopyranoside galactohydrolase
-
-
alpha-D-galactopyranoside galactohydrolase
Talaromyces flavus CCF2686
-
-
-
alpha-D-galactosidase
-
-
-
-
alpha-D-galactosidase
-
-
alpha-D-galactosidase
-
-
alpha-D-galactosidase
Q19AX0
-
alpha-D-galactosidase
-
-
alpha-D-galactosidase
Talaromyces flavus CCF2686
-
-
-
Alpha-D-galactoside galactohydrolase
-
-
-
-
Alpha-D-galactoside galactohydrolase
-
-
Alpha-D-galactoside galactohydrolase
Aspergillus niger M47
-
-
-
Alpha-D-galactoside galactohydrolase
-
-
Alpha-D-galactoside galactohydrolase
-
-
Alpha-D-galactoside galactohydrolase
Geobacillus stearothermophilus NCIM 5146, Geobacillus stearothermophilus NCIM-5146
-
-
-
Alpha-D-galactoside galactohydrolase
-
-
Alpha-D-galactoside galactohydrolase
-
-
Alpha-D-galactoside galactohydrolase
Penicillium chrysogenum LN33
-
-
-
Alpha-D-galactoside galactohydrolase
-
-
Alpha-D-galactoside galactohydrolase
Q19AX0
-
Alpha-D-galactoside galactohydrolase
-
-
alpha-Gal
-
-
alpha-Gal
-
-
alpha-Gal
-
-
alpha-Gal
Q97U94
-
alpha-Gal
Q97U94
-
-
alpha-Gal II
-
-
alpha-Gal III
Q7XIV4
-
alpha-gal1
-
-
alpha-galactosidase
-
-
alpha-galactosidase
-
-
alpha-galactosidase
-
-
alpha-galactosidase
Bispora sp.
-
-
alpha-galactosidase
-
-
alpha-galactosidase
-
-
alpha-galactosidase
-
-
alpha-galactosidase
-
-
alpha-galactosidase
-
-
alpha-galactosidase
Q7WWP9
-
alpha-galactosidase
-
-
alpha-galactosidase
-
-
alpha-galactosidase
P04824
-
alpha-galactosidase
-
-
alpha-galactosidase
-
-
alpha-galactosidase
Thalassococcus halodurans UST050418-052
-
-
-
alpha-galactosidase 1
-
-
alpha-galactosidase 2
-
-
alpha-galactosidase 3
-
-
alpha-galactosidase A
-
-
-
-
alpha-galactosidase A
-
-
alpha-galactosidase AgaA A355E
-
-
alpha-galactosidase AgaB
-
-
alpha-galactosidase I
Q02402
-
alpha-galactosidase II
-
-
alpha-galactosidase III
Q7XIV4
-
alpha-galactoside galactohydrolase
-
-
-
-
alpha-galactoside galactohydrolase
-, Q7XIV4
-
alphaGal1
-
-
alphaGal1
Talaromyces flavus CCF2686
-
-
-
E1 alpha-galactosidase
-
-
E2 alpha-galactosidase
-
-
E3 alpha-galactosidase
-
-
GalS
Q97U94
-
-
GH36 alpha-galactosidase
-
-
LaMel36A
Q7WWP9
-
Mel4A
Q9KAQ9
-
MelA
-
gene name
melibiase
-
-
-
-
retaining alpha-galactosidase
-
-
Tm GalA
O33835
-
TmGalA
Thermotoga maritima DSMZ3109
-
-
-
TnGalA
Thermotoga neapolitana DSMZ5068
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
9025-35-8
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
Absidia sp.
strain WL511
-
-
Manually annotated by BRENDA team
Absidia sp. WL511
strain WL511
-
-
Manually annotated by BRENDA team
type Runner and type Spanish
-
-
Manually annotated by BRENDA team
NRRL 3135
-
-
Manually annotated by BRENDA team
Aspergillus ficuum NRRL 3135
NRRL 3135
-
-
Manually annotated by BRENDA team
strain M47
-
-
Manually annotated by BRENDA team
Aspergillus niger M47
strain M47
-
-
Manually annotated by BRENDA team
Aspergillus paxillus
-
-
-
Manually annotated by BRENDA team
growth on guar gum as sole carbon source
-
-
Manually annotated by BRENDA team
strain ATCC 29148
Uniprot
Manually annotated by BRENDA team
Bifidobacterium animalis subsp. lactis LAFTI B94
strain LAFTI B94
-
-
Manually annotated by BRENDA team
strain 203
-
-
Manually annotated by BRENDA team
strain 203
Uniprot
Manually annotated by BRENDA team
Bifidobacterium breve 203
strain 203
-
-
Manually annotated by BRENDA team
Bifidobacterium breve 203
strain 203
Uniprot
Manually annotated by BRENDA team
strain LAFTI Bl536
-
-
Manually annotated by BRENDA team
Bifidobacterium longum LAFTI Bl536
strain LAFTI Bl536
-
-
Manually annotated by BRENDA team
Bispora sp.
-
-
-
Manually annotated by BRENDA team
Cajanus indicus
-
-
-
Manually annotated by BRENDA team
Calvatia cyanthiformis
-
-
-
Manually annotated by BRENDA team
Candida javanica
-
-
-
Manually annotated by BRENDA team
chestnut
-
-
Manually annotated by BRENDA team
Citrullus battich
watermelon
-
-
Manually annotated by BRENDA team
existence of at two isoforms, encoded by at least two genes
-
-
Manually annotated by BRENDA team
var. Robusta
Uniprot
Manually annotated by BRENDA team
Coffea sp.
green coffee beans
-
-
Manually annotated by BRENDA team
Corynebacterium murisepticum
-
-
-
Manually annotated by BRENDA team
a cold-tolerant cultivar, Guonong No. 25, and a cold sensitive cultivar, Guonong No. 41
-
-
Manually annotated by BRENDA team
strain UFV-1
-
-
Manually annotated by BRENDA team
Debaryomyces hansenii UFV-1
strain UFV-1
-
-
Manually annotated by BRENDA team
alpha-galactosidase AgaA; alpha-galactosidase AgaB
-
-
Manually annotated by BRENDA team
strain NCIM 5146
-
-
Manually annotated by BRENDA team
strain NCIM-5146
-
-
Manually annotated by BRENDA team
Geobacillus stearothermophilus NCIM 5146
strain NCIM 5146
-
-
Manually annotated by BRENDA team
Geobacillus stearothermophilus NCIM-5146
strain NCIM-5146
-
-
Manually annotated by BRENDA team
Gibberella sp.
strain F75
UniProt
Manually annotated by BRENDA team
strain F75
UniProt
Manually annotated by BRENDA team
cultivar Monarca
-
-
Manually annotated by BRENDA team
soybean
-
-
Manually annotated by BRENDA team
L. cv. Giant Gray Stripe
-
-
Manually annotated by BRENDA team
male patients with Fabry disease
-
-
Manually annotated by BRENDA team
patients with Fabry disease
-
-
Manually annotated by BRENDA team
patients with sporadic Parkinson's disease
-
-
Manually annotated by BRENDA team
Hypocrea jecorina RUT C-30
RUT C-30
-
-
Manually annotated by BRENDA team
strains LAFTI L10 and La4962
-
-
Manually annotated by BRENDA team
strains LAFTI L26 and Lc279
-
-
Manually annotated by BRENDA team
strain R08, high alpha-galactosidase activity during the stationary phase in a medium where raffinose is the only carbon source
-
-
Manually annotated by BRENDA team
Lactobacillus curvatus R08
strain R08, high alpha-galactosidase activity during the stationary phase in a medium where raffinose is the only carbon source
-
-
Manually annotated by BRENDA team
subspecies Lactobacillus delbrueckii bulgaricus, strain Lb1466
-
-
Manually annotated by BRENDA team
strain CRL722
Uniprot
Manually annotated by BRENDA team
Lactobacillus fermentum CRL722
strain CRL722
Uniprot
Manually annotated by BRENDA team
strain JK55, high alpha-galactosidase activity during the stationary phase in a medium where raffinose is the only carbon source
-
-
Manually annotated by BRENDA team
Leuconostoc mesenteroides JK55
strain JK55, high alpha-galactosidase activity during the stationary phase in a medium where raffinose is the only carbon source
-
-
Manually annotated by BRENDA team
no activity in Thalassobius aestuarii
-
-
-
Manually annotated by BRENDA team
no activity in Thalassobius aestuarii JC2049
-
-
-
Manually annotated by BRENDA team
no activity in Thalassobius gelatinovorus
-
-
-
Manually annotated by BRENDA team
no activity in Thalassobius gelatinovorus IAM 12617
-
-
-
Manually annotated by BRENDA team
no activity in Thalassobius mediterraneus
-
-
-
Manually annotated by BRENDA team
no activity in Thalassobius mediterraneus XSM19
-
-
-
Manually annotated by BRENDA team
alpha-Gal II; variant Nipponbare
Uniprot
Manually annotated by BRENDA team
L. var. Nipponbare
Uniprot
Manually annotated by BRENDA team
variant Nipponbare
Q7XIV4
UniProt
Manually annotated by BRENDA team
Penicillium chrysogenum LN33
strain LN33
-
-
Manually annotated by BRENDA team
Penicillium duponti
-
-
-
Manually annotated by BRENDA team
desert and oasis flies studied, male and female, Neot Hakikar (oasis), Jordan Valley spring (wet), Kfar Adumim starved (arid), Jordan Valley autumn (arid)
-
-
Manually annotated by BRENDA team
VKM B-2135 D
UniProt
Manually annotated by BRENDA team
Rhizopus sp.
18S rRNA sequence; strain F78 ACCC 30795
-
-
Manually annotated by BRENDA team
Rhizopus sp. F78
18S rRNA sequence; strain F78 ACCC 30795
-
-
Manually annotated by BRENDA team
; alpha-galactosidase precursor
SwissProt
Manually annotated by BRENDA team
sugar cane
-
-
Manually annotated by BRENDA team
Solanum lycopersicum Mill.
Mill.
SwissProt
Manually annotated by BRENDA team
Streptococcus thermophilus St1342
strain St1342
-
-
Manually annotated by BRENDA team
9917S2; 9929S1, 0177SA12, 096S14, 098SA1, 053A1
-
-
Manually annotated by BRENDA team
Streptomyces olivaceus 9917S2
9917S2
-
-
Manually annotated by BRENDA team
Tachigali multijuga
-
-
-
Manually annotated by BRENDA team
strain CCF2686
-
-
Manually annotated by BRENDA team
Talaromyces flavus CCF2686
strain CCF2686
-
-
Manually annotated by BRENDA team
UST050418-052
-
-
Manually annotated by BRENDA team
Thalassococcus halodurans UST050418-052
UST050418-052
-
-
Manually annotated by BRENDA team
strain CBS 395.62/b
-
-
Manually annotated by BRENDA team
Thermomyces lanuginosus CBS 395.62/b
strain CBS 395.62/b
-
-
Manually annotated by BRENDA team
Thermomyces lanuginosus IMI 158749
IMI 158749
-
-
Manually annotated by BRENDA team
strain MSB8
Uniprot
Manually annotated by BRENDA team
Thermotoga maritima DSMZ3109
DSMZ3109
-
-
Manually annotated by BRENDA team
Thermotoga neapolitana 5068
5068
-
-
Manually annotated by BRENDA team
Thermotoga neapolitana DSMZ5068
DSMZ5068
-
-
Manually annotated by BRENDA team
synonym Mortierella vinacea
UniProt
Manually annotated by BRENDA team
mung bean
-
-
Manually annotated by BRENDA team
biovar Microtus str. 91001
-
-
Manually annotated by BRENDA team
COFACTOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
NAD+
-
required for enzymatic activity
PDB
SCOP
CATH
ORGANISM
Bacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Bacteroides fragilis (strain ATCC 25285 / NCTC 9343)
Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
Lactobacillus brevis (strain ATCC 367 / JCM 1170)
Oryza sativa subsp. japonica
GENERAL STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
Mn2+ and reducing agents stabilizes activity in cell free extract
-
the enzyme is protease-resistant, when combined with trypsin, the enzyme retained over 90% degradability to soybean meal
C7SEV1
0.01% bovine serum albumin stabilizes enzyme stability
-
ORGANIC SOLVENT
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
additional information
-
after purification by three-phase partitioning method, enzyme shows improved acivity in organic solvents