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Adenocarcinoma of Lung
SAMHD1 can suppress lung adenocarcinoma progression through the negative regulation of STING.
Adenocarcinoma of Lung
SAMHD1 is down regulated in lung cancer by methylation and inhibits tumor cell proliferation.
Anemia
Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1.
Anemia
Effects of human SAMHD1 polymorphisms on HIV-1 susceptibility.
Anemia
Equine lentivirus counteracts SAMHD1 restriction by Rev-mediated degradation of SAMHD1 via the BECN1-dependent lysosomal pathway.
Anemia
Interplay of ancestral non-primate lentiviruses with the virus-restricting SAMHD1 proteins of their hosts.
Aneurysm
Tocilizumab reverses cerebral vasculopathy in a patient with homozygous SAMHD1 mutation.
Arbovirus Infections
SAMHD1 Enhances Chikungunya and Zika Virus Replication in Human Skin Fibroblasts.
Atherosclerosis
SAMHD1 Gene Mutations Are Associated with Cerebral Large-Artery Atherosclerosis.
Autoimmune Diseases
Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.
Autoimmune Diseases
Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a.
Autoimmune Diseases
Involvement of SAMHD1 in dNTP homeostasis and the maintenance of genomic integrity and oncotherapy (Review).
Autoimmune Diseases
Positive selection in dNTPase SAMHD1 throughout mammalian evolution.
Autoimmune Diseases
Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of Rp- and Sp-dNTP?S Diastereomers.
Autoimmune Diseases
SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations.
Autoimmune Diseases
SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.
Autoimmune Diseases
SAMHD1, the Aicardi-Goutières syndrome gene and retroviral restriction factor, is a phosphorolytic ribonuclease rather than a hydrolytic ribonuclease.
Autoimmune Diseases
SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection.
Autoimmune Diseases
SAMHD1-dependent retroviral control and escape in mice.
Autoimmune Diseases
SAMHD1: at the crossroads of cell proliferation, immune responses, and virus restriction.
Autoimmune Diseases
SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity.
Autoimmune Diseases
Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer.
Autoimmune Diseases
Single-stranded nucleic acids promote SAMHD1 complex formation.
Autoimmune Diseases
The SAM domain of mouse SAMHD1 is critical for its activation and regulation.
Autoimmune Diseases
The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation.
Brain Diseases
A SAMHD1 mutation associated with Aicardi-Goutières syndrome uncouples the ability of SAMHD1 to restrict HIV-1 from its ability to downmodulate type I interferon in humans.
Brain Diseases
Atypical Aicardi-Goutieres syndrome: Is the WRN locus a modifier?
Brain Diseases
Characterization of samhd1 Morphant Zebrafish Recapitulates Features of the Human Type I Interferonopathy Aicardi-Goutières Syndrome.
Brain Diseases
HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase.
Brain Diseases
Phenotypic Variation in Aicardi-Goutières Syndrome Explained by Cell-Specific IFN-Stimulated Gene Response and Cytokine Release.
Brain Diseases
SAMHD1 Functions and Human Diseases.
Brain Diseases
SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx.
Brain Diseases
SAMHD1-mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination.
Brain Diseases
Single-stranded nucleic acids promote SAMHD1 complex formation.
Carcinoma, Hepatocellular
Cyclin E2-CDK2 mediates SAMHD1 phosphorylation to abrogate its restriction of HBV replication in hepatoma cells.
Central Nervous System Diseases
miRNAs and SAMHD1 regulation in vitro and in a model of HIV CNS disease.
Cerebrovascular Disorders
SAMHD1 Gene Mutations Are Associated with Cerebral Large-Artery Atherosclerosis.
Colonic Neoplasms
Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance.
Colonic Neoplasms
Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins.
Colorectal Neoplasms
DNA-Sensing and Nuclease Gene Expressions as Markers for Colorectal Cancer Progression.
Colorectal Neoplasms
Dual roles of SAMHD1 in tumor development and chemoresistance to anticancer drugs.
Contracture
Familial Aicardi-Goutières syndrome due to SAMHD1 mutations is associated with chronic arthropathy and contractures.
COVID-19
SAMHD1 as the Potential Link Between SARS-CoV-2 Infection and Neurological Complications.
Cytomegalovirus Infections
Degradation of SAMHD1 Restriction Factor Through Cullin-Ring E3 Ligase Complexes During Human Cytomegalovirus Infection.
Cytomegalovirus Infections
SAMHD1 Modulates Early Steps during Human Cytomegalovirus Infection by Limiting NF-?B Activation.
Cytomegalovirus Infections
SAMHD1 phosphorylation and cytoplasmic relocalization after human cytomegalovirus infection limits its antiviral activity.
diacylglycerol kinase (atp) deficiency
The Deoxynucleoside Triphosphate Triphosphohydrolase Activity of SAMHD1 Protein Contributes to the Mitochondrial DNA Depletion Associated with Genetic Deficiency of Deoxyguanosine Kinase.
dntpase deficiency
Aicardi-Goutières syndrome-associated gene SAMHD1 preserves genome integrity by preventing R-loop formation at transcription-replication conflict regions.
dntpase deficiency
SAMHD1 Modulates Early Steps during Human Cytomegalovirus Infection by Limiting NF-?B Activation.
dntpase deficiency
SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.
dntpase deficiency
SAMHD1-dependent retroviral control and escape in mice.
dntpase deficiency
SAMHD1-mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination.
Encephalitis
Lentiviral infection of proliferating brain macrophages in HIV and simian immunodeficiency virus encephalitis despite sterile alpha motif and histidine-aspartate domain-containing protein 1 expression.
Encephalitis
Lentiviral infection of proliferating brain macrophages in SIV and HIV encephalitis despite SAMHD1 expression.
Epstein-Barr Virus Infections
Immune signatures correlate with L1 retrotransposition in gastrointestinal cancers.
Equine Infectious Anemia
Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1.
Equine Infectious Anemia
Effects of human SAMHD1 polymorphisms on HIV-1 susceptibility.
Equine Infectious Anemia
Equine lentivirus counteracts SAMHD1 restriction by Rev-mediated degradation of SAMHD1 via the BECN1-dependent lysosomal pathway.
Equine Infectious Anemia
Interplay of ancestral non-primate lentiviruses with the virus-restricting SAMHD1 proteins of their hosts.
Gastrointestinal Neoplasms
Immune signatures correlate with L1 retrotransposition in gastrointestinal cancers.
Genetic Diseases, Inborn
Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase.
Genetic Diseases, Inborn
Polymorphisms of the SAMHD1 Gene Are Not Associated with the Infection and Natural Control of HIV Type 1 in Europeans and African-Americans.
Hematologic Neoplasms
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.
Hepatitis
Hepatic Involvement in Aicardi-Goutières Syndrome.
Hepatitis B
Cyclin E2-CDK2 mediates SAMHD1 phosphorylation to abrogate its restriction of HBV replication in hepatoma cells.
Hepatitis B
Inhibition of hepatitis B virus replication by a dNTPase-dependent function of the host restriction factor SAMHD1.
Hepatitis B
Inhibition of Hepatitis B virus replication by SAMHD1.
Hepatitis B
Interferon-stimulated gene factor 3 complex is required for the induction of sterile ? motif and HD domain-containing protein 1 expression by interferon-? in SMMC-7721 cells.
Hepatitis B
Intertwined: SAMHD1 cellular functions, restriction, and viral evasion strategies.
Hepatitis B
Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle.
Herpes Simplex
Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells.
Herpes Simplex
Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1.
Herpes Simplex
SAMHD1 restricts herpes simplex virus type 1 (HSV-1) in macrophages by limiting DNA replication.
HIV Infections
Analysis of SAMHD1 Restriction by Flow Cytometry in Human Myeloid U937 Cells.
HIV Infections
BCL6 Inhibitor-Mediated Downregulation of Phosphorylated SAMHD1 and T Cell Activation Are Associated with Decreased HIV Infection and Reactivation.
HIV Infections
CD4+ Memory Stem Cells Are Infected by HIV-1 in a Manner Regulated in Part by SAMHD1 Expression.
HIV Infections
HSV-2 Cellular Programming Enables Productive HIV Infection in Dendritic Cells.
HIV Infections
IL-15 regulates susceptibility of CD4+ T cells to HIV infection.
HIV Infections
SAMHD1 does it again, now in resting T cells.
HIV Infections
Sterile alpha motif and histidine/aspartic acid domain-containing protein 1 (SAMHD1)-facilitated HIV restriction in astrocytes is regulated by miRNA-181a.
HIV Infections
Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection.
HIV Infections
Tight interplay among SAMHD1 protein level, cellular dNTP levels, and HIV-1 proviral DNA synthesis kinetics in human primary monocyte-derived macrophages.
HIV Infections
Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.
HIV Infections
Vpx-Independent Lentiviral Transduction and shRNA-Mediated Protein Knock-Down in Monocyte-Derived Dendritic Cells.
Hypersensitivity
SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.
Immune System Diseases
Involvement of SAMHD1 in dNTP homeostasis and the maintenance of genomic integrity and oncotherapy (Review).
Immune System Diseases
[Phenotypic variations in Aicardi-Goutieres syndrome caused by RNASEH2B gene mutations: report of two new cases].
Infections
A first-in-class NAE inhibitor, MLN4924, blocks lentiviral infection in myeloid cells by disrupting neddylation-dependent Vpx-mediated SAMHD1 degradation.
Infections
A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages.
Infections
A new activity for SAMHD1 in HIV restriction.
Infections
A SAMHD1 mutation associated with Aicardi-Goutières syndrome uncouples the ability of SAMHD1 to restrict HIV-1 from its ability to downmodulate type I interferon in humans.
Infections
A viral kinase counteracts in vivo restriction of murine cytomegalovirus by SAMHD1.
Infections
Aicardi-Goutieres syndrome: from patients to genes and beyond.
Infections
Allosteric regulation of the human and mouse deoxyribonucleotide triphosphohydrolase sterile ?-motif/histidine-aspartate domain-containing protein 1 (SAMHD1).
Infections
Antagonism of SAMHD1 is actively maintained in natural infections of simian immunodeficiency virus.
Infections
Brain Microglial Cells Are Highly Susceptible to HIV-1 Infection and Spread.
Infections
CD4+ Memory Stem Cells Are Infected by HIV-1 in a Manner Regulated in Part by SAMHD1 Expression.
Infections
Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells.
Infections
Cell Cycle Regulation in Macrophages and Susceptibility to HIV-1.
Infections
Cell-to-Cell Spreading of HIV-1 in Myeloid Target Cells Escapes SAMHD1 Restriction.
Infections
Cellular and Biochemical Mechanisms of the Retroviral Restriction Factor SAMHD1.
Infections
Characterization of the interactions between SIVrcm Vpx and red-capped mangabey SAMHD1.
Infections
Co-evolution of primate SAMHD1 and lentivirus Vpx leads to the loss of the vpx gene in HIV-1 ancestor.
Infections
Complement-Opsonized HIV-1 Overcomes Restriction in Dendritic Cells.
Infections
Constitutive Siglec-1 expression confers susceptibility to HIV-1 infection of human dendritic cell precursors.
Infections
Contribution of oligomerization to the anti-HIV-1 properties of SAMHD1.
Infections
Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1.
Infections
Cytotoxic cell populations developed during treatment with tyrosine kinase inhibitors protect autologous CD4+ T cells from HIV-1 infection.
Infections
Dasatinib inhibits HIV-1 replication through the interference of SAMHD1 phosphorylation in CD4+ T cells.
Infections
Degradation of SAMHD1 Restriction Factor Through Cullin-Ring E3 Ligase Complexes During Human Cytomegalovirus Infection.
Infections
Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55? holoenzymes during mitotic exit.
Infections
Distinct characteristics of endometrial and decidual macrophages and regulation of their permissivity to HIV-1 infection by SAMHD1.
Infections
DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV-1 infection of macrophages.
Infections
DNA damage induces a SAMHD1-mediated block to the infection of macrophages by HIV-1.
Infections
Dual effect of the broad spectrum kinase inhibitor midostaurin in acute and latent HIV-1 infection.
Infections
Effects of human SAMHD1 polymorphisms on HIV-1 susceptibility.
Infections
Efficient generation of isogenic primary human myeloid cells using CRISPR-Cas9 ribonucleoproteins.
Infections
Efficient transduction of myeloid cells by an HIV-1-derived lentiviral vector that packages the Vpx accessory protein.
Infections
Equine lentivirus counteracts SAMHD1 restriction by Rev-mediated degradation of SAMHD1 via the BECN1-dependent lysosomal pathway.
Infections
Evaluation of resistance to HIV-1 infection ex vivo of PBMCs isolated from patients with chronic myeloid leukemia treated with different tyrosine kinase inhibitors.
Infections
Evidence for IFN?-induced, SAMHD1-independent inhibitors of early HIV-1 infection.
Infections
Expression of MDM2 in macrophages promotes the early post-entry steps of HIV-1 infection through inhibition of p53.
Infections
Functional organization of human SAMHD1 and mechanisms of HIV-1 restriction.
Infections
GTP Is the Primary Activator of the Anti-HIV Restriction Factor SAMHD1.
Infections
Hiding in plain sight: how HIV evades innate immune responses.
Infections
HIV Type 1 Infection of Plasmacytoid and Myeloid Dendritic Cells Is Restricted by High Levels of SAMHD1 and Cannot be Counteracted by Vpx.
Infections
HIV-1 Vif: a guardian of the virus that opens up a new era in the research field of restriction factors.
Infections
HIV-1/HIV-2 versus SAMHD1 restriction: a tale of two viruses.
Infections
HIV-2 and SIVmac accessory virulence factor Vpx down-regulates SAMHD1 enzyme catalysis prior to proteasome-dependent degradation.
Infections
HIV-2 Depletes CD4 T Cells through Pyroptosis despite Vpx-Dependent Degradation of SAMHD1.
Infections
Host restriction factor SAMHD1 limits human T cell leukemia virus type 1 infection of monocytes via STING-mediated apoptosis.
Infections
Identification of Cellular Proteins Interacting with the Retroviral Restriction Factor SAMHD1.
Infections
IL-7 Induces SAMHD1 Phosphorylation in CD4+ T Lymphocytes, Improving Early Steps of HIV-1 Life Cycle.
Infections
Immune Activation Influences SAMHD1 Expression and Vpx-mediated SAMHD1 Degradation during Chronic HIV-1 Infection.
Infections
Incomplete Suppression of HIV-1 by SAMHD1 Permits Efficient Macrophage Infection.
Infections
Increased SAMHD1 transcript expression correlates with interferon-related genes in HIV-1-infected patients.
Infections
Inhibition of Vpx-mediated SAMHD1 and Vpr-mediated HLTF degradation by selective disruption of viral CRL4 (DCAF1) E3 ubiquitin ligase assembly.
Infections
Interference with SAMHD1 restores late gene expression of modified vaccinia virus Ankara (MVA) in human dendritic cells and abrogates type I interferon expression.
Infections
Interferon-induced sterile alpha motif and histidine/aspartic acid domain-containing protein 1 expression in astrocytes and microglia is mediated by microRNA-181a.
Infections
Lentiviral infection of proliferating brain macrophages in HIV and simian immunodeficiency virus encephalitis despite sterile alpha motif and histidine-aspartate domain-containing protein 1 expression.
Infections
Lentiviral infection of proliferating brain macrophages in SIV and HIV encephalitis despite SAMHD1 expression.
Infections
Lentivirus Vpr and Vpx accessory proteins usurp the cullin4-DDB1 (DCAF1) E3 ubiquitin ligase.
Infections
Long-term HIV-1 infection induces an antiviral state in primary macrophages.
Infections
Low dNTP levels are necessary but may not be sufficient for lentiviral restriction by SAMHD1.
Infections
Low SAMHD1 expression following T-cell activation and proliferation renders CD4+ T cells susceptible to HIV-1.
Infections
MCPIP1/regnase-I inhibits simian immunodeficiency virus and is not counteracted by Vpx.
Infections
Molecular cloning and characterizations of porcine SAMHD1 and its roles in replication of highly pathogenic porcine reproductive and respiratory syndrome virus.
Infections
Molecular determinants for recognition of divergent SAMHD1 proteins by the lentiviral accessory protein Vpx.
Infections
Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification.
Infections
Nucleotide embargo by SAMHD1: a strategy to block retroviral infection.
Infections
Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction.
Infections
Phosphorylation of mouse SAMHD1 regulates its restriction of human immunodeficiency virus type 1 infection, but not murine leukemia virus infection.
Infections
Phosphorylation of murine SAMHD1 regulates its antiretroviral activity.
Infections
Polymorphisms of the SAMHD1 Gene Are Not Associated with the Infection and Natural Control of HIV Type 1 in Europeans and African-Americans.
Infections
Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1.
Infections
Restriction of HIV-1 Replication in Primary Macrophages by IL-12 and IL-18 through the Upregulation of SAMHD1.
Infections
Restriction of retroviral infection of macrophages.
Infections
Restriction of Virus Infection but Not Catalytic dNTPase Activity Is Regulated by Phosphorylation of SAMHD1.
Infections
Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle.
Infections
Roles of SAMHD1 in antiviral defense, autoimmunity and cancer.
Infections
SAMHD1 controls cell cycle status, apoptosis and HIV-1 infection in monocytic THP-1 cells.
Infections
SAMHD1 degradation enhances active suppression of dendritic cell maturation by HIV-1.
Infections
SAMHD1 Enhances Chikungunya and Zika Virus Replication in Human Skin Fibroblasts.
Infections
SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells.
Infections
SAMHD1 has differential impact on the efficacies of HIV nucleoside reverse transcriptase inhibitors.
Infections
SAMHD1 Impairs HIV-1 Gene Expression and Negatively Modulates Reactivation of Viral Latency in CD4+ T Cells.
Infections
SAMHD1 in Retroviral Restriction and Innate Immune Sensing--Should We Leash the Hound?
Infections
SAMHD1 is active in cycling cells permissive to HIV-1 infection.
Infections
SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx.
Infections
SAMHD1 Joins the Red Queen's Court.
Infections
Samhd1 knockout mice: modeling retrovirus restriction in vivo.
Infections
SAMHD1 Limits HIV-1 Antigen Presentation by Monocyte-Derived Dendritic Cells.
Infections
SAMHD1 Modulates Early Steps during Human Cytomegalovirus Infection by Limiting NF-?B Activation.
Infections
SAMHD1 phosphorylation and cytoplasmic relocalization after human cytomegalovirus infection limits its antiviral activity.
Infections
SAMHD1 Phosphorylation Coordinates the Anti-HIV-1 Response by Diverse Interferons and Tyrosine Kinase Inhibition.
Infections
SAMHD1 Polymorphisms were Significantly Correlated with HIV/SIV Virus Load in PBMC from Chinese Rhesus Macaques and Cynomolgus Macaques
Infections
SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.
Infections
SAMHD1 restricts HIV-1 cell-to-cell transmission and limits immune detection in monocyte-derived dendritic cells.
Infections
SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons.
Infections
SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.
Infections
SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates.
Infections
SAMHD1 specifically restricts retroviruses through its RNase activity.
Infections
SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-?B and interferon pathways.
Infections
SAMHD1 transcript upregulation during SIV infection of the central nervous system does not associate with reduced viral load.
Infections
SAMHD1's protein expression profile in humans.
Infections
SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection.
Infections
SAMHD1-dependent retroviral control and escape in mice.
Infections
SAMHD1: a new contributor to HIV-1 restriction in resting CD4+ T-cells.
Infections
SAMHD1: a new insight into HIV-1 restriction in myeloid cells.
Infections
SAMHD1: mechanisms of regulation and viral evasion.
Infections
Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization.
Infections
Structural basis of cellular dNTP regulation by SAMHD1.
Infections
Structural basis of lentiviral subversion of a cellular protein degradation pathway.
Infections
Sulforaphane Inhibits HIV Infection of Macrophages through Nrf2.
Infections
Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection.
Infections
TGF? Induces a SAMHD1-Independent Post-Entry Restriction to HIV-1 Infection of Human Epithelial Langerhans Cells.
Infections
The Ability of Primate Lentiviruses to Degrade the Monocyte Restriction Factor SAMHD1 Preceded the Birth of the Viral Accessory Protein Vpx.
Infections
The ability of SAMHD1 to block HIV-1 but not SIV requires expression of MxB.
Infections
The Deoxynucleoside Triphosphate Triphosphohydrolase Activity of SAMHD1 Protein Contributes to the Mitochondrial DNA Depletion Associated with Genetic Deficiency of Deoxyguanosine Kinase.
Infections
The Effect of Baicalin on the Expression Profiles of Long Non-Coding RNAs and mRNAs in Porcine Aortic Vascular Endothelial Cells Infected with Haemophilus parasuis.
Infections
The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells.
Infections
The expression profile of sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1) in feline tissues.
Infections
The Frequency of Cytidine Editing of Viral DNA Is Differentially Influenced by Vpx and Nucleosides during HIV-1 or SIVMAC Infection of Dendritic Cells.
Infections
The G1/S Specific Cyclin D2 Is a Regulator of HIV-1 Restriction in Non-proliferating Cells.
Infections
The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation.
Infections
The ribonuclease activity of SAMHD1 is required for HIV-1 restriction.
Infections
The SAM domain of mouse SAMHD1 is critical for its activation and regulation.
Infections
The Susceptibility of Primate Lentiviruses to Nucleosides and Vpx during Infection of Dendritic Cells Is Regulated by CA.
Infections
Tight interplay among SAMHD1 protein level, cellular dNTP levels, and HIV-1 proviral DNA synthesis kinetics in human primary monocyte-derived macrophages.
Infections
TLR4-Mediated Pathway Triggers Interferon-Independent G0 Arrest and Antiviral SAMHD1 Activity in Macrophages.
Infections
TLR7/8 agonist induces a post-entry SAMHD1-independent block to HIV-1 infection of monocytes.
Infections
TRAF6 and TAK1 Contribute to SAMHD1-Mediated Negative Regulation of NF-?B Signaling.
Infections
TRIM21-mediated proteasomal degradation of SAMHD1 regulates its antiviral activity.
Infections
Tyrosine Kinase Inhibition: a New Perspective in the Fight against HIV.
Infections
Unmasking immune sensing of retroviruses: interplay between innate sensors and host effectors.
Infections
Vpx enhances innate immune responses independently of SAMHD1 during HIV-1 infection.
Infections
Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein.
Infections
With me or against me: Tumor suppressor and drug resistance activities of SAMHD1.
Influenza, Human
The Chemokine CCL5 Inhibits the Replication of Influenza A Virus Through SAMHD1 Modulation.
Intracranial Hemorrhages
A homozygous mutation in RNU4ATAC as a cause of microcephalic osteodysplastic primordial dwarfism type I (MOPD I) with associated pigmentary disorder.
Intracranial Hemorrhages
Characterization of samhd1 Morphant Zebrafish Recapitulates Features of the Human Type I Interferonopathy Aicardi-Goutières Syndrome.
Joint Diseases
Familial Aicardi-Goutières syndrome due to SAMHD1 mutations is associated with chronic arthropathy and contractures.
Lentivirus Infections
Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1.
Lentivirus Infections
SAMHD1: a novel antiviral factor in intrinsic immunity.
Lentivirus Infections
Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein.
Leukemia
Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1.
Leukemia
FMS-like tyrosine kinase 3 (FLT3) modulates key enzymes of nucleotide metabolism implicated in cytarabine responsiveness in pediatric acute leukemia.
Leukemia
Host restriction factor SAMHD1 limits human T cell leukemia virus type 1 infection of monocytes via STING-mediated apoptosis.
Leukemia
Phosphorylation of mouse SAMHD1 regulates its restriction of human immunodeficiency virus type 1 infection, but not murine leukemia virus infection.
Leukemia
SAMHD1 Impairs HIV-1 Gene Expression and Negatively Modulates Reactivation of Viral Latency in CD4+ T Cells.
Leukemia
SAMHD1 inhibits epithelial cell transformation in vitro and affects leukemia development in xenograft mice.
Leukemia
SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.
Leukemia
SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia.
Leukemia
SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP.
Leukemia
SAMHD1 restricts HIV-1 replication and regulates interferon production in mouse myeloid cells.
Leukemia
Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML.
Leukemia
Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins.
Leukemia, Lymphocytic, Chronic, B-Cell
Dual roles of SAMHD1 in tumor development and chemoresistance to anticancer drugs.
Leukemia, Lymphocytic, Chronic, B-Cell
Impaired dNTPase activity of SAMHD1 by phosphomimetic mutation of Thr-592.
Leukemia, Lymphocytic, Chronic, B-Cell
SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.
Leukemia, Lymphocytic, Chronic, B-Cell
Structural basis of cellular dNTP regulation by SAMHD1.
Leukemia, Myeloid, Acute
Corrigendum: SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Evidence for SAMHD1 Tumor Suppressor Functions in Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
Expression and Relationship of SAMHD1 with Other Apoptotic and Autophagic Genes in Acute Myeloid Leukemia Patients.
Leukemia, Myeloid, Acute
FMS-like tyrosine kinase 3 (FLT3) modulates key enzymes of nucleotide metabolism implicated in cytarabine responsiveness in pediatric acute leukemia.
Leukemia, Myeloid, Acute
Low-level expression of SAMHD1 in acute myeloid leukemia (AML) blasts correlates with improved outcome upon consolidation chemotherapy with high-dose cytarabine-based regimens.
Leukemia, Myeloid, Acute
Pharmacological strategies to overcome treatment resistance in acute myeloid leukemia: increasing leukemic drug exposure by targeting the resistance factor SAMHD1 and the toxicity factor Top2?.
Leukemia, Myeloid, Acute
SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.
Leukemia, Myeloid, Acute
The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1.
Leukemia, Myeloid, Acute
With me or against me: Tumor suppressor and drug resistance activities of SAMHD1.
Leukemia, Prolymphocytic, T-Cell
SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia.
Leukemia, T-Cell
Host restriction factor SAMHD1 limits human T cell leukemia virus type 1 infection of monocytes via STING-mediated apoptosis.
Leukemia, T-Cell
SAMHD1 Impairs HIV-1 Gene Expression and Negatively Modulates Reactivation of Viral Latency in CD4+ T Cells.
Liver Neoplasms
Identification of natural splice variants of SAMHD1 in virus-infected HCC.
Lung Neoplasms
Dual roles of SAMHD1 in tumor development and chemoresistance to anticancer drugs.
Lung Neoplasms
Graphene Oxide-Facilitated Comprehensive Analysis of Cellular Nucleic Acid Binding Proteins for Lung Cancer.
Lung Neoplasms
SAMHD1 is down regulated in lung cancer by methylation and inhibits tumor cell proliferation.
Lupus Erythematosus, Cutaneous
Familial chilblain lupus due to a gain-of-function mutation in STING.
Lupus Erythematosus, Systemic
Aicardi-Goutieres Syndrome and Systemic Lupus Erythematosus (SLE) in a 12-Year-Old Boy With SAMHD1 Mutations.
Lupus Erythematosus, Systemic
SAMHD1 prevents autoimmunity by maintaining genome stability.
Lupus Erythematosus, Systemic
Single-stranded nucleic acids promote SAMHD1 complex formation.
Lymphocytosis
HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase.
Lymphoma
BCL6 Inhibitor-Mediated Downregulation of Phosphorylated SAMHD1 and T Cell Activation Are Associated with Decreased HIV Infection and Reactivation.
Lymphoma
SAMHD1 mutations in mantle cell lymphoma are recurrent and confer in vitro resistance to nucleoside analogues.
Lymphoma
The impact of SAMHD1 expression and mutation status in mantle cell lymphoma: An analysis of the MCL Younger and Elderly trial.
Lymphoma, B-Cell
BCL6 Inhibitor-Mediated Downregulation of Phosphorylated SAMHD1 and T Cell Activation Are Associated with Decreased HIV Infection and Reactivation.
Lymphoma, B-Cell
The impact of SAMHD1 expression and mutation status in mantle cell lymphoma: An analysis of the MCL Younger and Elderly trial.
Lymphoma, Mantle-Cell
SAMHD1 mutations in mantle cell lymphoma are recurrent and confer in vitro resistance to nucleoside analogues.
Lymphoma, Mantle-Cell
The impact of SAMHD1 expression and mutation status in mantle cell lymphoma: An analysis of the MCL Younger and Elderly trial.
Lymphoma, Non-Hodgkin
B cell lymphoma with IRF4 rearrangement: A clinicopathological study of 13 cases.
Lymphoma, T-Cell, Cutaneous
Aggressive CD8(+) epidermotropic cutaneous T-cell lymphoma associated with homozygous mutation in SAMHD1.
Lymphoma, T-Cell, Cutaneous
Exogenous expression of SAMHD1 inhibits proliferation and induces apoptosis in cutaneous T-cell lymphoma-derived HuT78 cells.
Neoplasm Metastasis
DNA-Sensing and Nuclease Gene Expressions as Markers for Colorectal Cancer Progression.
Neoplasm Metastasis
SAMHD1 inhibits epithelial cell transformation in vitro and affects leukemia development in xenograft mice.
Neoplasms
A High-Throughput Enzyme-Coupled Assay for SAMHD1 dNTPase.
Neoplasms
Aicardi-Goutières syndrome-associated gene SAMHD1 preserves genome integrity by preventing R-loop formation at transcription-replication conflict regions.
Neoplasms
Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.
Neoplasms
Defective modulation of LINE-1 retrotransposition by cancer-associated SAMHD1 mutants.
Neoplasms
Dual roles of SAMHD1 in tumor development and chemoresistance to anticancer drugs.
Neoplasms
Epigenomic and genomic analysis of transcriptome modulation in skin cutaneous melanoma.
Neoplasms
Erratum: Castellví, M. et al. Pharmacological Modulation of SAMHD1 Activity by CDK4/6 Inhibitors Improves Anticancer Therapy. Cancers 2020, 12, 713.
Neoplasms
Evidence for SAMHD1 Tumor Suppressor Functions in Acute Myeloid Leukemia.
Neoplasms
Genome-wide bioinformatics analysis reveals CTCFL is upregulated in high-grade epithelial ovarian cancer.
Neoplasms
Graphene Oxide-Facilitated Comprehensive Analysis of Cellular Nucleic Acid Binding Proteins for Lung Cancer.
Neoplasms
Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance.
Neoplasms
Immune signatures correlate with L1 retrotransposition in gastrointestinal cancers.
Neoplasms
Low-level expression of SAMHD1 in acute myeloid leukemia (AML) blasts correlates with improved outcome upon consolidation chemotherapy with high-dose cytarabine-based regimens.
Neoplasms
Mass spectrometry based proteomics profiling of human monocytes.
Neoplasms
Pharmacological Modulation of SAMHD1 Activity by CDK4/6 Inhibitors Improves Anticancer Therapy.
Neoplasms
PNP inhibitors selectively kill cancer cells lacking SAMHD1.
Neoplasms
Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of Rp- and Sp-dNTP?S Diastereomers.
Neoplasms
Purine-Metabolising Enzymes and Apoptosis in Cancer.
Neoplasms
Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications.
Neoplasms
Roles of SAMHD1 in antiviral defense, autoimmunity and cancer.
Neoplasms
SAMHD1 acetylation enhances its deoxynucleotide triphosphohydrolase activity and promotes cancer cell proliferation.
Neoplasms
SAMHD1 acts at stalled replication forks to prevent interferon induction.
Neoplasms
SAMHD1 can suppress lung adenocarcinoma progression through the negative regulation of STING.
Neoplasms
SAMHD1 Functions and Human Diseases.
Neoplasms
SAMHD1 in cancer: curse or cure?
Neoplasms
SAMHD1 inhibits epithelial cell transformation in vitro and affects leukemia development in xenograft mice.
Neoplasms
SAMHD1 is a barrier to antimetabolite-based cancer therapies.
Neoplasms
SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.
Neoplasms
SAMHD1 is down regulated in lung cancer by methylation and inhibits tumor cell proliferation.
Neoplasms
SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia.
Neoplasms
SAMHD1 modulates in vitro proliferation of acute myeloid leukemia-derived THP-1 cells through the PI3K-Akt-p27 axis.
Neoplasms
SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.
Neoplasms
SAMHD1 protects cancer cells from various nucleoside-based antimetabolites.
Neoplasms
SAMHD1 restrains aberrant nucleotide insertions at repair junctions generated by DNA end joining.
Neoplasms
SAMHD1-dependent retroviral control and escape in mice.
Neoplasms
SAMHD1-mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination.
Neoplasms
SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity.
Neoplasms
Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer.
Neoplasms
Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins.
Neoplasms
Targeting the Nucleotide Metabolism Proteins of the NUDIX Family and SAMHD1 in Cancer.
Neoplasms
The dNTPase activity of SAMHD1 is important for its suppression of innate immune responses in differentiated monocytic cells.
Neoplasms
The druggability of intracellular nucleotide-degrading enzymes.
Neoplasms
The missing link: allostery and catalysis in the anti-viral protein SAMHD1.
Neoplasms
The SAM domain of mouse SAMHD1 is critical for its activation and regulation.
Neoplasms
The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1.
Neoplasms
With me or against me: Tumor suppressor and drug resistance activities of SAMHD1.
Neoplasms
[SAMHD1 acts at stalled replication forks to prevent interferon induction].
Nervous System Diseases
miRNAs and SAMHD1 regulation in vitro and in a model of HIV CNS disease.
Nervous System Diseases
SAMHD1 restricts HIV-1 replication and regulates interferon production in mouse myeloid cells.
Porcine Reproductive and Respiratory Syndrome
Molecular cloning and characterizations of porcine SAMHD1 and its roles in replication of highly pathogenic porcine reproductive and respiratory syndrome virus.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
FMS-like tyrosine kinase 3 (FLT3) modulates key enzymes of nucleotide metabolism implicated in cytarabine responsiveness in pediatric acute leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
FMS-like tyrosine kinase 3 (FLT3) modulates key enzymes of nucleotide metabolism implicated in cytarabine responsiveness in pediatric acute leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabine.
Retroviridae Infections
SAMHD1 host restriction factor: a link with innate immune sensing of retrovirus infection.
Starvation
Restricting HIV the SAMHD1 way: through nucleotide starvation.
Starvation
SAMHD1-dependent retroviral control and escape in mice.
Stroke
Cerebral arterial stenoses and stroke: novel features of Aicardi-Goutières syndrome caused by the Arg164X mutation in SAMHD1 are associated with altered cytokine expression.
Stroke
Homozygous mutation in SAMHD1 gene causes cerebral vasculopathy and early onset stroke.
Stroke
SAMHD1 Gene Mutations Are Associated with Cerebral Large-Artery Atherosclerosis.
Stroke
Tocilizumab reverses cerebral vasculopathy in a patient with homozygous SAMHD1 mutation.
Superinfection
Incomplete Suppression of HIV-1 by SAMHD1 Permits Efficient Macrophage Infection.
Vaccinia
Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells.
Vaccinia
Interference with SAMHD1 restores late gene expression of modified vaccinia virus Ankara (MVA) in human dendritic cells and abrogates type I interferon expression.
Vaccinia
Interferon ? and ? Have Differential Effects on SAMHD1, a Potent Antiviral Protein, in Feline Lymphocytes.
Vesicular Stomatitis
Moderate Restriction of Macrophage-Tropic Human Immunodeficiency Virus Type 1 by SAMHD1 in Monocyte-Derived Macrophages.
Vesicular Stomatitis
SAMHD1 Limits HIV-1 Antigen Presentation by Monocyte-Derived Dendritic Cells.
Vesicular Stomatitis
TGF? Induces a SAMHD1-Independent Post-Entry Restriction to HIV-1 Infection of Human Epithelial Langerhans Cells.
Viremia
The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells.
Virus Diseases
Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase.
Virus Diseases
Antagonism of SAMHD1 is actively maintained in natural infections of simian immunodeficiency virus.
Virus Diseases
Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.
Virus Diseases
Degradation of SAMHD1 Restriction Factor Through Cullin-Ring E3 Ligase Complexes During Human Cytomegalovirus Infection.
Virus Diseases
HIV-2/SIV viral protein X counteracts HUSH repressor complex.
Virus Diseases
Identification of the SAMHD1 gene in grass carp and its roles in inducing apoptosis and inhibiting GCRV proliferation.
Virus Diseases
Involvement of SAMHD1 in dNTP homeostasis and the maintenance of genomic integrity and oncotherapy (Review).
Virus Diseases
Phosphorylation of mouse SAMHD1 regulates its restriction of human immunodeficiency virus type 1 infection, but not murine leukemia virus infection.
Virus Diseases
Phosphorylation of murine SAMHD1 regulates its antiretroviral activity.
Virus Diseases
Restriction of Virus Infection but Not Catalytic dNTPase Activity Is Regulated by Phosphorylation of SAMHD1.
Virus Diseases
SAMHD1 acts at stalled replication forks to prevent interferon induction.
Virus Diseases
SAMHD1 Functions and Human Diseases.
Virus Diseases
SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx.
Virus Diseases
SAMHD1 specifically restricts retroviruses through its RNase activity.
Virus Diseases
SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-?B and interferon pathways.
Virus Diseases
Single-stranded nucleic acids promote SAMHD1 complex formation.
Virus Diseases
The dNTPase activity of SAMHD1 is important for its suppression of innate immune responses in differentiated monocytic cells.
Virus Diseases
The eukaryotic elongation factor eEF1A1 interacts with SAMHD1.
Virus Diseases
The Frequency of Cytidine Editing of Viral DNA Is Differentially Influenced by Vpx and Nucleosides during HIV-1 or SIVMAC Infection of Dendritic Cells.
Virus Diseases
The poly-proline tail of SIVmac Vpx provides gain of function for resistance to a cryptic proteasome-dependent degradation pathway.
Virus Diseases
TRAF6 and TAK1 Contribute to SAMHD1-Mediated Negative Regulation of NF-?B Signaling.
Virus Diseases
Viral infection: SAMHD1 cuts the power to HIV-1.
Virus Diseases
Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein.
Werner Syndrome
Atypical Aicardi-Goutieres syndrome: Is the WRN locus a modifier?
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3.1.5.B1 dNTPase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
