Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 3.1.4.4 - phospholipase D and Organism(s) Drosophila melanogaster

for references in articles please use BRENDA:EC3.1.4.4
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.4 Phosphoric-diester hydrolases
                3.1.4.4 phospholipase D
IUBMB Comments
Also acts on other phosphatidyl esters.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Drosophila melanogaster
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
Synonyms
pld, phospholipase d, nape-pld, phospholipase d1, dermonecrotic toxin, phospholipase d2, pc-pld, pldalpha, rpld1, spo14, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
AtPLDalpha1
-
-
-
-
AtPLDalpha2
-
-
-
-
AtPLDbeta1
-
-
-
-
AtPLDbeta2
-
-
-
-
AtPLDdelta
-
-
-
-
AtPLDepsilon
-
-
-
-
AtPLDgamma1
-
-
-
-
AtPLDgamma2
-
-
-
-
AtPLDgamma3
-
-
-
-
AtPLDp1
-
-
-
-
AtPLDp2
-
-
-
-
AtPLDzeta
-
-
-
-
choline phosphatase
-
-
-
-
hPLD1
-
-
-
-
hPLD2
-
-
-
-
lecithinase D
-
-
-
-
lipophosphodiesterase II
-
-
-
-
Meiosis-specific sporulation protein SPO14
-
-
-
-
mPLD1
-
-
-
-
mPLD2
-
-
-
-
Phosphatidylcholine-hydrolyzing phospholipase D1
-
-
-
-
Phosphatidylcholine-hydrolyzing phospholipase D2
-
-
-
-
phospholipase D1
-
-
Phospholipase D1 PHOX and PX containing domain
-
-
-
-
Phospholipase D2 PHOX and PX containing domain
-
-
-
-
PLD delta
-
-
-
-
PLD epsilon
-
-
-
-
PLD zeta
-
-
-
-
PLD1C
-
-
-
-
PLDalpha
-
-
-
-
PLDalpha3
-
-
-
-
PLDbeta
-
-
-
-
PLDdelta1
-
-
-
-
PLDzeta1
-
-
-
-
PLDzeta2
-
-
-
-
rPLD1
-
-
-
-
rPLD2
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
phosphatidylcholine phosphatidohydrolase
Also acts on other phosphatidyl esters.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-87-0
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
phosphatidylcholine + H2O
choline + phosphatidate
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
phosphatidylcholine + H2O
choline + phosphatidate
show the reaction diagram
additional information
?
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
localized to photoreceptor cell body
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
-
phospholipase D1 is regulated by ADP-ribosylation factors which are themselves regulators of vesicle trafficking
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
B7YZT5_DROME
1364
0
155371
TrEMBL
other Location (Reliability: 3)
A4UZ54_DROME
1260
0
143537
TrEMBL
other Location (Reliability: 1)
Q9BP35_DROME
1278
0
145438
TrEMBL
other Location (Reliability: 1)
Q9BP34_DROME
1278
0
145475
TrEMBL
other Location (Reliability: 1)
Q6NR18_DROME
739
0
84500
TrEMBL
other Location (Reliability: 1)
Q7KML4_DROME
1278
0
145456
TrEMBL
other Location (Reliability: 1)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic tree, expression analysis and regulation
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
LaLonde, M.M.; Janssens, H.; Rosenbaum, E.; Choi, S.Y.; Gergen, J.P.; Colley, N.J.; Stark, W.S.; Frohman, M.A.
Regulation of phototransduction responsiveness and retinal degeneration by a phospholipase D-generated signaling lipid
J. Cell Biol.
169
471-479
2005
Drosophila melanogaster
Manually annotated by BRENDA team
LaLonde, M.; Janssens, H.; Yun, S.; Crosby, J.; Redina, O.; Olive, V.; Altshuller, Y.M.; Choi, S.Y.; Du, G.; Gergen, J.P.; Frohman, M.A.
A role for phospholipase D in Drosophila embryonic cellularization
BMC Dev. Biol.
6
60
2006
Drosophila melanogaster
Manually annotated by BRENDA team
Riebeling, C.; Bourgoin, S.; Shields, D.
Caspase cleavage of phospholipase D1 in vitro alters its regulation and reveals a novel property of the loop region
Biochim. Biophys. Acta
1781
376-382
2008
Drosophila melanogaster, Mammalia
Manually annotated by BRENDA team
Raghu, P.; Manifava, M.; Coadwell, J.; Ktistakis, N.T.
Emerging findings from studies of phospholipase D in model organisms (and a short update on phosphatidic acid effectors)
Biochim. Biophys. Acta
1791
889-897
2009
Saccharomyces cerevisiae, Caenorhabditis elegans, Danio rerio (A2BG86), Danio rerio, Homo sapiens (O14939), Homo sapiens (Q13393), Dictyostelium discoideum (Q54UK0), Dictyostelium discoideum (Q54WR4), Dictyostelium discoideum (Q54Z25), Drosophila melanogaster (Q7KML4)
Manually annotated by BRENDA team
Thakur, R.; Panda, A.; Coessens, E.; Raj, N.; Yadav, S.; Balakrishnan, S.; Zhang, Q.; Georgiev, P.; Basak, B.; Pasricha, R.; Wakelam, M.; Ktistakis, N.; Raghu, P.
Phospholipase D activity couples plasma membrane endocytosis with retromer dependent recycling
eLife
5
e18515
2016
Drosophila melanogaster
Manually annotated by BRENDA team